-- dump date   	20140619_050247
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
583355000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
583355000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
583355000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
583355000004	Walker A motif; other site
583355000005	ATP binding site [chemical binding]; other site
583355000006	Walker B motif; other site
583355000007	arginine finger; other site
583355000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
583355000009	DnaA box-binding interface [nucleotide binding]; other site
583355000010	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
583355000011	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
583355000012	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355000013	S-adenosylmethionine binding site [chemical binding]; other site
583355000014	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
583355000015	Walker A motif; other site
583355000016	ATP binding site [chemical binding]; other site
583355000017	Walker B motif; other site
583355000018	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
583355000019	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
583355000020	IHF - DNA interface [nucleotide binding]; other site
583355000021	IHF dimer interface [polypeptide binding]; other site
583355000022	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
583355000023	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
583355000024	dimer interface [polypeptide binding]; other site
583355000025	motif 1; other site
583355000026	active site
583355000027	motif 2; other site
583355000028	motif 3; other site
583355000029	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
583355000030	anticodon binding site; other site
583355000031	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
583355000032	ArsC family; Region: ArsC; pfam03960
583355000033	putative ArsC-like catalytic residues; other site
583355000034	putative TRX-like catalytic residues [active]
583355000035	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333
583355000036	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
583355000037	homodimer interface [polypeptide binding]; other site
583355000038	metal binding site [ion binding]; metal-binding site
583355000039	Protein of unknown function DUF45; Region: DUF45; pfam01863
583355000040	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
583355000041	Cna protein B-type domain; Region: Cna_B_2; pfam13715
583355000042	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
583355000043	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
583355000044	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
583355000045	heme-binding residues [chemical binding]; other site
583355000046	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
583355000047	molybdopterin cofactor binding site; other site
583355000048	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
583355000049	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
583355000050	4Fe-4S binding domain; Region: Fer4; cl02805
583355000051	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
583355000052	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
583355000053	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
583355000054	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
583355000055	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
583355000056	Low-spin heme binding site [chemical binding]; other site
583355000057	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
583355000058	D-pathway; other site
583355000059	Putative water exit pathway; other site
583355000060	Binuclear center (active site) [active]
583355000061	K-pathway; other site
583355000062	Putative proton exit pathway; other site
583355000063	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
583355000064	Cytochrome c; Region: Cytochrom_C; pfam00034
583355000065	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
583355000066	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
583355000067	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
583355000068	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
583355000069	dimer interface [polypeptide binding]; other site
583355000070	active site
583355000071	heme binding site [chemical binding]; other site
583355000072	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
583355000073	Sulfatase; Region: Sulfatase; pfam00884
583355000074	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355000075	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
583355000076	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
583355000077	Fasciclin domain; Region: Fasciclin; pfam02469
583355000078	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
583355000079	Fasciclin domain; Region: Fasciclin; pfam02469
583355000080	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355000081	Sulfatase; Region: Sulfatase; pfam00884
583355000082	Electron transfer DM13; Region: DM13; cl02735
583355000083	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
583355000084	DEAD-like helicases superfamily; Region: DEXDc; smart00487
583355000085	ATP binding site [chemical binding]; other site
583355000086	putative Mg++ binding site [ion binding]; other site
583355000087	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
583355000088	nucleotide binding region [chemical binding]; other site
583355000089	Domain of unknown function DUF21; Region: DUF21; pfam01595
583355000090	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
583355000091	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
583355000092	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
583355000093	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
583355000094	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
583355000095	Walker A/P-loop; other site
583355000096	ATP binding site [chemical binding]; other site
583355000097	Q-loop/lid; other site
583355000098	ABC transporter signature motif; other site
583355000099	Walker B; other site
583355000100	D-loop; other site
583355000101	H-loop/switch region; other site
583355000102	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
583355000103	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
583355000104	HlyD family secretion protein; Region: HlyD_3; pfam13437
583355000105	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
583355000106	Aconitate hydratase 2 N-terminus; Region: Aconitase_2_N; pfam06434
583355000107	substrate binding site [chemical binding]; other site
583355000108	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
583355000109	substrate binding site [chemical binding]; other site
583355000110	ligand binding site [chemical binding]; other site
583355000111	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
583355000112	Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178
583355000113	calcium binding site [ion binding]; other site
583355000114	active site
583355000115	catalytic residues [active]
583355000116	Uncharacterized conserved protein [Function unknown]; Region: COG3379
583355000117	Sulfatase; Region: Sulfatase; cl17466
583355000118	TPR repeat; Region: TPR_11; pfam13414
583355000119	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
583355000120	binding surface
583355000121	TPR motif; other site
583355000122	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
583355000123	active site
583355000124	catalytic residues [active]
583355000125	Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178
583355000126	calcium binding site [ion binding]; other site
583355000127	active site
583355000128	catalytic residues [active]
583355000129	probable metal-binding protein; Region: matur_matur; TIGR03853
583355000130	electron transport complex, RnfABCDGE type, B subunit; Region: rnfB; TIGR01944
583355000131	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153
583355000132	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153
583355000133	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
583355000134	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
583355000135	[4Fe-4S] binding site [ion binding]; other site
583355000136	molybdopterin cofactor binding site; other site
583355000137	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
583355000138	molybdopterin cofactor binding site; other site
583355000139	Cytochrome c552; Region: Cytochrom_C552; pfam02335
583355000140	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
583355000141	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
583355000142	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
583355000143	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
583355000144	Rrf2 family protein; Region: rrf2_super; TIGR00738
583355000145	Transcriptional regulator; Region: Rrf2; pfam02082
583355000146	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
583355000147	active site
583355000148	catalytic residues [active]
583355000149	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257
583355000150	PKC phosphorylation site [posttranslational modification]; other site
583355000151	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
583355000152	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
583355000153	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
583355000154	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
583355000155	ligand binding site [chemical binding]; other site
583355000156	flexible hinge region; other site
583355000157	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
583355000158	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
583355000159	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
583355000160	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
583355000161	galactonate dehydratase; Provisional; Region: PRK14017
583355000162	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
583355000163	active site pocket [active]
583355000164	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
583355000165	TIGR03546 family protein; Region: TIGR03546
583355000166	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
583355000167	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
583355000168	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355000169	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355000170	short chain dehydrogenase; Provisional; Region: PRK06172
583355000171	classical (c) SDRs; Region: SDR_c; cd05233
583355000172	NAD(P) binding site [chemical binding]; other site
583355000173	active site
583355000174	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
583355000175	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
583355000176	homotrimer interaction site [polypeptide binding]; other site
583355000177	putative active site [active]
583355000178	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
583355000179	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
583355000180	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
583355000181	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
583355000182	PKC phosphorylation site [posttranslational modification]; other site
583355000183	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
583355000184	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
583355000185	catalytic triad [active]
583355000186	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
583355000187	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
583355000188	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
583355000189	ATP binding site [chemical binding]; other site
583355000190	putative Mg++ binding site [ion binding]; other site
583355000191	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
583355000192	nucleotide binding region [chemical binding]; other site
583355000193	ATP-binding site [chemical binding]; other site
583355000194	Double zinc ribbon; Region: DZR; pfam12773
583355000195	Ribosomal L40e family; Region: Ribosomal_L40e; cl00671
583355000196	Uncharacterized conserved protein [Function unknown]; Region: COG0397
583355000197	hypothetical protein; Validated; Region: PRK00029
583355000198	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
583355000199	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
583355000200	NAD binding site [chemical binding]; other site
583355000201	active site
583355000202	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
583355000203	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
583355000204	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
583355000205	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
583355000206	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
583355000207	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
583355000208	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
583355000209	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
583355000210	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
583355000211	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
583355000212	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
583355000213	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
583355000214	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
583355000215	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
583355000216	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
583355000217	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
583355000218	TrkA-N domain; Region: TrkA_N; pfam02254
583355000219	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
583355000220	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
583355000221	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
583355000222	active site
583355000223	intersubunit interface [polypeptide binding]; other site
583355000224	catalytic residue [active]
583355000225	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
583355000226	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
583355000227	substrate binding site [chemical binding]; other site
583355000228	ATP binding site [chemical binding]; other site
583355000229	Staphylococcal nuclease homologues; Region: SNc; smart00318
583355000230	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
583355000231	Catalytic site; other site
583355000232	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
583355000233	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
583355000234	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
583355000235	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
583355000236	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
583355000237	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
583355000238	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
583355000239	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
583355000240	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
583355000241	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
583355000242	DNA-binding site [nucleotide binding]; DNA binding site
583355000243	RNA-binding motif; other site
583355000244	Methyltransferase domain; Region: Methyltransf_23; pfam13489
583355000245	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355000246	S-adenosylmethionine binding site [chemical binding]; other site
583355000247	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
583355000248	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
583355000249	putative metal binding site [ion binding]; other site
583355000250	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
583355000251	putative metal binding site [ion binding]; other site
583355000252	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
583355000253	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
583355000254	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
583355000255	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
583355000256	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
583355000257	DNA Polymerase Y-family; Region: PolY_like; cd03468
583355000258	active site
583355000259	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
583355000260	DNA binding site [nucleotide binding]
583355000261	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
583355000262	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
583355000263	active site
583355000264	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
583355000265	generic binding surface II; other site
583355000266	generic binding surface I; other site
583355000267	Transposase IS200 like; Region: Y1_Tnp; cl00848
583355000268	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
583355000269	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
583355000270	FtsX-like permease family; Region: FtsX; pfam02687
583355000271	FtsX-like permease family; Region: FtsX; pfam02687
583355000272	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
583355000273	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
583355000274	Walker A/P-loop; other site
583355000275	ATP binding site [chemical binding]; other site
583355000276	Q-loop/lid; other site
583355000277	ABC transporter signature motif; other site
583355000278	Walker B; other site
583355000279	D-loop; other site
583355000280	H-loop/switch region; other site
583355000281	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
583355000282	active site
583355000283	catalytic triad [active]
583355000284	oxyanion hole [active]
583355000285	switch loop; other site
583355000286	Helix-turn-helix domain; Region: HTH_18; pfam12833
583355000287	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355000288	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
583355000289	ligand binding site [chemical binding]; other site
583355000290	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
583355000291	ligand binding site [chemical binding]; other site
583355000292	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
583355000293	metal binding site [ion binding]; metal-binding site
583355000294	ligand binding site [chemical binding]; other site
583355000295	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
583355000296	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
583355000297	ATP binding site [chemical binding]; other site
583355000298	putative Mg++ binding site [ion binding]; other site
583355000299	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
583355000300	nucleotide binding region [chemical binding]; other site
583355000301	ATP-binding site [chemical binding]; other site
583355000302	Domain of unknown function (DUF4261); Region: DUF4261; pfam14080
583355000303	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779
583355000304	Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077
583355000305	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
583355000306	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
583355000307	Protein of unknown function (DUF1593); Region: DUF1593; pfam07632
583355000308	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
583355000309	Major Facilitator Superfamily; Region: MFS_1; pfam07690
583355000310	putative substrate translocation pore; other site
583355000311	AAA domain; Region: AAA_21; pfam13304
583355000312	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
583355000313	Abi-like protein; Region: Abi_2; pfam07751
583355000314	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
583355000315	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
583355000316	dimerization interface [polypeptide binding]; other site
583355000317	ATP binding site [chemical binding]; other site
583355000318	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
583355000319	dimerization interface [polypeptide binding]; other site
583355000320	ATP binding site [chemical binding]; other site
583355000321	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
583355000322	putative active site [active]
583355000323	catalytic triad [active]
583355000324	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
583355000325	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
583355000326	Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308
583355000327	Leucine rich repeat; Region: LRR_8; pfam13855
583355000328	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
583355000329	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
583355000330	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
583355000331	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
583355000332	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355000333	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355000334	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
583355000335	Glycosyl hydrolase 43-like family consists of hypothetical proteins; Region: GH43_like_2; cd08994
583355000336	active site
583355000337	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
583355000338	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
583355000339	active site
583355000340	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
583355000341	MarR family; Region: MarR_2; cl17246
583355000342	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
583355000343	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
583355000344	HlyD family secretion protein; Region: HlyD_3; pfam13437
583355000345	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
583355000346	MarC family integral membrane protein; Region: MarC; cl00919
583355000347	ornithine carbamoyltransferase; Provisional; Region: PRK00779
583355000348	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
583355000349	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
583355000350	acetylornithine aminotransferase; Provisional; Region: PRK02627
583355000351	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
583355000352	inhibitor-cofactor binding pocket; inhibition site
583355000353	pyridoxal 5'-phosphate binding site [chemical binding]; other site
583355000354	catalytic residue [active]
583355000355	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
583355000356	nucleotide binding site [chemical binding]; other site
583355000357	substrate binding site [chemical binding]; other site
583355000358	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
583355000359	heterotetramer interface [polypeptide binding]; other site
583355000360	active site pocket [active]
583355000361	cleavage site
583355000362	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
583355000363	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
583355000364	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
583355000365	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
583355000366	23S rRNA interface [nucleotide binding]; other site
583355000367	L3 interface [polypeptide binding]; other site
583355000368	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
583355000369	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
583355000370	SmpB-tmRNA interface; other site
583355000371	homoserine kinase; Provisional; Region: PRK01212
583355000372	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
583355000373	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
583355000374	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
583355000375	response regulator GlrR; Provisional; Region: PRK15115
583355000376	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
583355000377	NADH(P)-binding; Region: NAD_binding_10; pfam13460
583355000378	NAD(P) binding site [chemical binding]; other site
583355000379	putative active site [active]
583355000380	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
583355000381	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
583355000382	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
583355000383	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
583355000384	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
583355000385	putative binding surface; other site
583355000386	active site
583355000387	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
583355000388	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355000389	ATP binding site [chemical binding]; other site
583355000390	Mg2+ binding site [ion binding]; other site
583355000391	G-X-G motif; other site
583355000392	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
583355000393	Response regulator receiver domain; Region: Response_reg; pfam00072
583355000394	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355000395	active site
583355000396	phosphorylation site [posttranslational modification]
583355000397	intermolecular recognition site; other site
583355000398	dimerization interface [polypeptide binding]; other site
583355000399	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
583355000400	dimerization interface [polypeptide binding]; other site
583355000401	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
583355000402	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
583355000403	dimer interface [polypeptide binding]; other site
583355000404	putative CheW interface [polypeptide binding]; other site
583355000405	CheW-like domain; Region: CheW; pfam01584
583355000406	Response regulator receiver domain; Region: Response_reg; pfam00072
583355000407	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355000408	active site
583355000409	phosphorylation site [posttranslational modification]
583355000410	intermolecular recognition site; other site
583355000411	dimerization interface [polypeptide binding]; other site
583355000412	Response regulator receiver domain; Region: Response_reg; pfam00072
583355000413	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355000414	active site
583355000415	phosphorylation site [posttranslational modification]
583355000416	intermolecular recognition site; other site
583355000417	dimerization interface [polypeptide binding]; other site
583355000418	Response regulator receiver domain; Region: Response_reg; pfam00072
583355000419	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355000420	active site
583355000421	phosphorylation site [posttranslational modification]
583355000422	dimerization interface [polypeptide binding]; other site
583355000423	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
583355000424	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
583355000425	motif 1; other site
583355000426	active site
583355000427	motif 2; other site
583355000428	motif 3; other site
583355000429	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
583355000430	four helix bundle protein; Region: TIGR02436
583355000431	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
583355000432	tartrate dehydrogenase; Region: TTC; TIGR02089
583355000433	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
583355000434	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
583355000435	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355000436	active site
583355000437	phosphorylation site [posttranslational modification]
583355000438	intermolecular recognition site; other site
583355000439	dimerization interface [polypeptide binding]; other site
583355000440	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
583355000441	DNA binding site [nucleotide binding]
583355000442	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
583355000443	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
583355000444	catalytic triad [active]
583355000445	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
583355000446	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
583355000447	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
583355000448	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
583355000449	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
583355000450	putative active site; other site
583355000451	catalytic triad [active]
583355000452	putative dimer interface [polypeptide binding]; other site
583355000453	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
583355000454	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
583355000455	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
583355000456	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
583355000457	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
583355000458	Part of AAA domain; Region: AAA_19; pfam13245
583355000459	Family description; Region: UvrD_C_2; pfam13538
583355000460	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
583355000461	AAA domain; Region: AAA_30; pfam13604
583355000462	Family description; Region: UvrD_C_2; pfam13538
583355000463	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
583355000464	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
583355000465	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
583355000466	mutatrotase, YjhT family; Region: muta_rot_YjhT; TIGR03547
583355000467	Galactose oxidase, central domain; Region: Kelch_3; cl02701
583355000468	Kelch motif; Region: Kelch_1; pfam01344
583355000469	Kelch motif; Region: Kelch_1; pfam01344
583355000470	Galactose oxidase, central domain; Region: Kelch_3; cl02701
583355000471	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
583355000472	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
583355000473	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
583355000474	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
583355000475	Trp docking motif [polypeptide binding]; other site
583355000476	active site
583355000477	PQQ-like domain; Region: PQQ_2; pfam13360
583355000478	PQQ-like domain; Region: PQQ_2; pfam13360
583355000479	Family description; Region: VCBS; pfam13517
583355000480	Family description; Region: VCBS; pfam13517
583355000481	Family description; Region: VCBS; pfam13517
583355000482	FG-GAP repeat; Region: FG-GAP; pfam01839
583355000483	Fn3 associated; Region: Fn3_assoc; pfam13287
583355000484	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
583355000485	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
583355000486	FeS/SAM binding site; other site
583355000487	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
583355000488	DNA topoisomerase III; Validated; Region: PRK08173
583355000489	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
583355000490	active site
583355000491	putative interdomain interaction site [polypeptide binding]; other site
583355000492	putative metal-binding site [ion binding]; other site
583355000493	putative nucleotide binding site [chemical binding]; other site
583355000494	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
583355000495	domain I; other site
583355000496	DNA binding groove [nucleotide binding]
583355000497	phosphate binding site [ion binding]; other site
583355000498	domain II; other site
583355000499	domain III; other site
583355000500	nucleotide binding site [chemical binding]; other site
583355000501	catalytic site [active]
583355000502	domain IV; other site
583355000503	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
583355000504	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
583355000505	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
583355000506	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
583355000507	adenylate kinase; Reviewed; Region: adk; PRK00279
583355000508	AMP-binding site [chemical binding]; other site
583355000509	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
583355000510	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
583355000511	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
583355000512	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
583355000513	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
583355000514	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
583355000515	active site
583355000516	SlyX; Region: SlyX; pfam04102
583355000517	Cupin domain; Region: Cupin_2; pfam07883
583355000518	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
583355000519	active site 2 [active]
583355000520	active site 1 [active]
583355000521	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
583355000522	dimerization interface [polypeptide binding]; other site
583355000523	putative DNA binding site [nucleotide binding]; other site
583355000524	Transcriptional regulator [Transcription]; Region: IclR; COG1414
583355000525	putative Zn2+ binding site [ion binding]; other site
583355000526	Bacterial transcriptional regulator; Region: IclR; pfam01614
583355000527	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
583355000528	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
583355000529	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
583355000530	CoA-transferase family III; Region: CoA_transf_3; pfam02515
583355000531	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
583355000532	CoA-transferase family III; Region: CoA_transf_3; pfam02515
583355000533	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
583355000534	enoyl-CoA hydratase; Provisional; Region: PRK07658
583355000535	substrate binding site [chemical binding]; other site
583355000536	oxyanion hole (OAH) forming residues; other site
583355000537	trimer interface [polypeptide binding]; other site
583355000538	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
583355000539	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
583355000540	NAD(P) binding site [chemical binding]; other site
583355000541	catalytic residues [active]
583355000542	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
583355000543	Amidohydrolase; Region: Amidohydro_2; pfam04909
583355000544	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355000545	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355000546	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
583355000547	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
583355000548	NAD(P) binding site [chemical binding]; other site
583355000549	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
583355000550	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
583355000551	NADP binding site [chemical binding]; other site
583355000552	homodimer interface [polypeptide binding]; other site
583355000553	active site
583355000554	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
583355000555	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
583355000556	NADP binding site [chemical binding]; other site
583355000557	homodimer interface [polypeptide binding]; other site
583355000558	active site
583355000559	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
583355000560	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
583355000561	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
583355000562	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
583355000563	active site
583355000564	catalytic residues [active]
583355000565	Sulfatase; Region: Sulfatase; cl17466
583355000566	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355000567	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355000568	Sulfatase; Region: Sulfatase; pfam00884
583355000569	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355000570	Sulfatase; Region: Sulfatase; pfam00884
583355000571	maltose O-acetyltransferase; Provisional; Region: PRK10092
583355000572	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
583355000573	active site
583355000574	substrate binding site [chemical binding]; other site
583355000575	trimer interface [polypeptide binding]; other site
583355000576	CoA binding site [chemical binding]; other site
583355000577	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355000578	Sulfatase; Region: Sulfatase; cl17466
583355000579	Predicted permeases [General function prediction only]; Region: COG0701
583355000580	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
583355000581	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
583355000582	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
583355000583	FeoA domain; Region: FeoA; pfam04023
583355000584	Ecdysteroid kinase; Region: EcKinase; cl17738
583355000585	Phosphotransferase enzyme family; Region: APH; pfam01636
583355000586	Inositol monophosphatase family; Region: Inositol_P; pfam00459
583355000587	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
583355000588	active site
583355000589	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
583355000590	putative binding surface; other site
583355000591	active site
583355000592	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
583355000593	Na binding site [ion binding]; other site
583355000594	Predicted permeases [General function prediction only]; Region: COG0795
583355000595	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
583355000596	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
583355000597	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
583355000598	putative RNA binding site [nucleotide binding]; other site
583355000599	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355000600	S-adenosylmethionine binding site [chemical binding]; other site
583355000601	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
583355000602	Putative serine esterase (DUF676); Region: DUF676; pfam05057
583355000603	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
583355000604	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
583355000605	Sulfate transporter family; Region: Sulfate_transp; pfam00916
583355000606	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
583355000607	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
583355000608	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
583355000609	active site
583355000610	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
583355000611	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
583355000612	active site
583355000613	catalytic site [active]
583355000614	substrate binding site [chemical binding]; other site
583355000615	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
583355000616	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
583355000617	putative active site [active]
583355000618	substrate binding site [chemical binding]; other site
583355000619	putative cosubstrate binding site; other site
583355000620	catalytic site [active]
583355000621	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
583355000622	substrate binding site [chemical binding]; other site
583355000623	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
583355000624	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
583355000625	RHS Repeat; Region: RHS_repeat; pfam05593
583355000626	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
583355000627	RHS Repeat; Region: RHS_repeat; pfam05593
583355000628	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
583355000629	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
583355000630	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355000631	Sulfatase; Region: Sulfatase; pfam00884
583355000632	protoporphyrinogen oxidase; Region: PLN02576
583355000633	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
583355000634	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
583355000635	substrate binding site [chemical binding]; other site
583355000636	active site
583355000637	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
583355000638	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
583355000639	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355000640	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
583355000641	NAD(P) binding site [chemical binding]; other site
583355000642	active site
583355000643	FOG: CBS domain [General function prediction only]; Region: COG0517
583355000644	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
583355000645	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
583355000646	phosphopeptide binding site; other site
583355000647	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
583355000648	recombination protein RecR; Reviewed; Region: recR; PRK00076
583355000649	RecR protein; Region: RecR; pfam02132
583355000650	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
583355000651	putative active site [active]
583355000652	putative metal-binding site [ion binding]; other site
583355000653	tetramer interface [polypeptide binding]; other site
583355000654	DNA polymerase I; Provisional; Region: PRK05755
583355000655	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
583355000656	active site
583355000657	metal binding site 1 [ion binding]; metal-binding site
583355000658	putative 5' ssDNA interaction site; other site
583355000659	metal binding site 3; metal-binding site
583355000660	metal binding site 2 [ion binding]; metal-binding site
583355000661	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
583355000662	putative DNA binding site [nucleotide binding]; other site
583355000663	putative metal binding site [ion binding]; other site
583355000664	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
583355000665	active site
583355000666	catalytic site [active]
583355000667	substrate binding site [chemical binding]; other site
583355000668	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
583355000669	active site
583355000670	DNA binding site [nucleotide binding]
583355000671	catalytic site [active]
583355000672	Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137
583355000673	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
583355000674	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
583355000675	putative Cl- selectivity filter; other site
583355000676	putative pore gating glutamate residue; other site
583355000677	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
583355000678	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
583355000679	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
583355000680	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
583355000681	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
583355000682	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
583355000683	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
583355000684	G1 box; other site
583355000685	GTP/Mg2+ binding site [chemical binding]; other site
583355000686	Switch I region; other site
583355000687	G2 box; other site
583355000688	G3 box; other site
583355000689	Switch II region; other site
583355000690	G4 box; other site
583355000691	G5 box; other site
583355000692	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
583355000693	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
583355000694	active site
583355000695	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
583355000696	Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077
583355000697	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779
583355000698	Domain of unknown function (DUF4272); Region: DUF4272; pfam14094
583355000699	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425
583355000700	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
583355000701	integron integrase; Region: integrase_gron; TIGR02249
583355000702	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
583355000703	active site
583355000704	DNA binding site [nucleotide binding]
583355000705	Int/Topo IB signature motif; other site
583355000706	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
583355000707	MoaE interaction surface [polypeptide binding]; other site
583355000708	MoeB interaction surface [polypeptide binding]; other site
583355000709	thiocarboxylated glycine; other site
583355000710	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
583355000711	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
583355000712	GTP binding site; other site
583355000713	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
583355000714	trimer interface [polypeptide binding]; other site
583355000715	dimer interface [polypeptide binding]; other site
583355000716	putative active site [active]
583355000717	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
583355000718	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
583355000719	dimer interface [polypeptide binding]; other site
583355000720	putative functional site; other site
583355000721	putative MPT binding site; other site
583355000722	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
583355000723	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
583355000724	FeS/SAM binding site; other site
583355000725	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
583355000726	Transcriptional regulator [Transcription]; Region: LysR; COG0583
583355000727	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
583355000728	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
583355000729	dimerization interface [polypeptide binding]; other site
583355000730	NMT1-like family; Region: NMT1_2; pfam13379
583355000731	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
583355000732	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
583355000733	NMT1-like family; Region: NMT1_2; pfam13379
583355000734	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
583355000735	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
583355000736	dimer interface [polypeptide binding]; other site
583355000737	conserved gate region; other site
583355000738	putative PBP binding loops; other site
583355000739	ABC-ATPase subunit interface; other site
583355000740	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
583355000741	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
583355000742	Walker A/P-loop; other site
583355000743	ATP binding site [chemical binding]; other site
583355000744	Q-loop/lid; other site
583355000745	ABC transporter signature motif; other site
583355000746	Walker B; other site
583355000747	D-loop; other site
583355000748	H-loop/switch region; other site
583355000749	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
583355000750	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
583355000751	Walker A/P-loop; other site
583355000752	ATP binding site [chemical binding]; other site
583355000753	Q-loop/lid; other site
583355000754	ABC transporter signature motif; other site
583355000755	Walker B; other site
583355000756	D-loop; other site
583355000757	H-loop/switch region; other site
583355000758	putative sialic acid transporter; Region: 2A0112; TIGR00891
583355000759	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
583355000760	putative substrate translocation pore; other site
583355000761	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
583355000762	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
583355000763	active site
583355000764	Catalytic domain of Protein Kinases; Region: PKc; cd00180
583355000765	active site
583355000766	ATP binding site [chemical binding]; other site
583355000767	substrate binding site [chemical binding]; other site
583355000768	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
583355000769	activation loop (A-loop); other site
583355000770	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567
583355000771	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
583355000772	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
583355000773	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
583355000774	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
583355000775	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
583355000776	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
583355000777	[4Fe-4S] binding site [ion binding]; other site
583355000778	molybdopterin cofactor binding site; other site
583355000779	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
583355000780	molybdopterin cofactor binding site; other site
583355000781	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
583355000782	Flavodoxin; Region: Flavodoxin_1; pfam00258
583355000783	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
583355000784	FAD binding pocket [chemical binding]; other site
583355000785	FAD binding motif [chemical binding]; other site
583355000786	catalytic residues [active]
583355000787	NAD binding pocket [chemical binding]; other site
583355000788	phosphate binding motif [ion binding]; other site
583355000789	beta-alpha-beta structure motif; other site
583355000790	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
583355000791	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
583355000792	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
583355000793	B12 binding site [chemical binding]; other site
583355000794	cobalt ligand [ion binding]; other site
583355000795	Uroporphyrinogen decarboxylase (URO-D); Region: URO-D; pfam01208
583355000796	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
583355000797	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
583355000798	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
583355000799	Protein of unknown function (DUF1638); Region: DUF1638; pfam07796
583355000800	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
583355000801	Cupin domain; Region: Cupin_2; cl17218
583355000802	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
583355000803	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355000804	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
583355000805	hexamer (dimer of trimers) interface [polypeptide binding]; other site
583355000806	substrate binding site [chemical binding]; other site
583355000807	trimer interface [polypeptide binding]; other site
583355000808	Mn binding site [ion binding]; other site
583355000809	Class I aldolases; Region: Aldolase_Class_I; cl17187
583355000810	catalytic residue [active]
583355000811	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
583355000812	Transcriptional regulators [Transcription]; Region: PurR; COG1609
583355000813	Helix-turn-helix domain; Region: HTH_18; pfam12833
583355000814	Transcriptional regulators [Transcription]; Region: PurR; COG1609
583355000815	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
583355000816	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355000817	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355000818	Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178
583355000819	calcium binding site [ion binding]; other site
583355000820	active site
583355000821	catalytic residues [active]
583355000822	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
583355000823	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
583355000824	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
583355000825	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355000826	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355000827	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355000828	Sulfatase; Region: Sulfatase; pfam00884
583355000829	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
583355000830	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
583355000831	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
583355000832	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
583355000833	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
583355000834	putative substrate translocation pore; other site
583355000835	Major Facilitator Superfamily; Region: MFS_1; pfam07690
583355000836	Glycosyl hydrolase family 43, uncharacterized proteins; Region: GH43_like_1; cd08992
583355000837	active site
583355000838	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355000839	Sulfatase; Region: Sulfatase; pfam00884
583355000840	Sulfatase; Region: Sulfatase; cl17466
583355000841	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355000842	Sulfatase; Region: Sulfatase; pfam00884
583355000843	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
583355000844	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355000845	Sulfatase; Region: Sulfatase; cl17466
583355000846	Sulfatase; Region: Sulfatase; cl17466
583355000847	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355000848	Sulfatase; Region: Sulfatase; cl17466
583355000849	Sulfatase; Region: Sulfatase; cl17466
583355000850	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
583355000851	active site
583355000852	catalytic residues [active]
583355000853	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
583355000854	active site
583355000855	catalytic residues [active]
583355000856	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
583355000857	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
583355000858	Helix-turn-helix domain; Region: HTH_18; pfam12833
583355000859	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355000860	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
583355000861	Na binding site [ion binding]; other site
583355000862	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
583355000863	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
583355000864	Low molecular weight phosphatase family; Region: LMWPc; cd00115
583355000865	active site
583355000866	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
583355000867	Active site serine [active]
583355000868	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
583355000869	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
583355000870	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
583355000871	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
583355000872	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
583355000873	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
583355000874	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
583355000875	SLBB domain; Region: SLBB; pfam10531
583355000876	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
583355000877	Chain length determinant protein; Region: Wzz; cl15801
583355000878	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
583355000879	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
583355000880	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
583355000881	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
583355000882	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
583355000883	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
583355000884	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
583355000885	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
583355000886	trimer interface [polypeptide binding]; other site
583355000887	active site
583355000888	substrate binding site [chemical binding]; other site
583355000889	CoA binding site [chemical binding]; other site
583355000890	O-Antigen ligase; Region: Wzy_C; pfam04932
583355000891	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
583355000892	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
583355000893	active site
583355000894	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
583355000895	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
583355000896	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
583355000897	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
583355000898	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
583355000899	substrate binding site; other site
583355000900	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
583355000901	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355000902	NAD(P) binding site [chemical binding]; other site
583355000903	active site
583355000904	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
583355000905	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
583355000906	Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488
583355000907	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
583355000908	Protein of unknown function (DUF563); Region: DUF563; pfam04577
583355000909	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
583355000910	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
583355000911	TIGR02597 family protein; Region: TIGR02597
583355000912	Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022
583355000913	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
583355000914	Bacterial sugar transferase; Region: Bac_transf; pfam02397
583355000915	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
583355000916	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
583355000917	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
583355000918	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
583355000919	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
583355000920	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
583355000921	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
583355000922	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
583355000923	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
583355000924	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
583355000925	Transcriptional regulator [Transcription]; Region: LysR; COG0583
583355000926	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
583355000927	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
583355000928	dimerization interface [polypeptide binding]; other site
583355000929	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
583355000930	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
583355000931	catalytic residue [active]
583355000932	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
583355000933	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
583355000934	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
583355000935	shikimate binding site; other site
583355000936	NAD(P) binding site [chemical binding]; other site
583355000937	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
583355000938	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
583355000939	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
583355000940	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
583355000941	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
583355000942	Cl- selectivity filter; other site
583355000943	Cl- binding residues [ion binding]; other site
583355000944	pore gating glutamate residue; other site
583355000945	dimer interface [polypeptide binding]; other site
583355000946	H+/Cl- coupling transport residue; other site
583355000947	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
583355000948	FOG: CBS domain [General function prediction only]; Region: COG0517
583355000949	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
583355000950	Histidine kinase; Region: HisKA_3; pfam07730
583355000951	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355000952	ATP binding site [chemical binding]; other site
583355000953	Mg2+ binding site [ion binding]; other site
583355000954	G-X-G motif; other site
583355000955	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
583355000956	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355000957	active site
583355000958	phosphorylation site [posttranslational modification]
583355000959	intermolecular recognition site; other site
583355000960	dimerization interface [polypeptide binding]; other site
583355000961	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
583355000962	DNA binding residues [nucleotide binding]
583355000963	dimerization interface [polypeptide binding]; other site
583355000964	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355000965	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355000966	Glycosyl hydrolase 43-like family consists of hypothetical proteins; Region: GH43_like_2; cd08994
583355000967	active site
583355000968	Sulfatase; Region: Sulfatase; cl17466
583355000969	Sulfatase; Region: Sulfatase; cl17466
583355000970	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355000971	Sulfatase; Region: Sulfatase; cl17466
583355000972	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355000973	Sulfatase; Region: Sulfatase; pfam00884
583355000974	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355000975	Sulfatase; Region: Sulfatase; pfam00884
583355000976	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355000977	Sulfatase; Region: Sulfatase; pfam00884
583355000978	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
583355000979	Sulfatase; Region: Sulfatase; cl17466
583355000980	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355000981	Sulfatase; Region: Sulfatase; cl17466
583355000982	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355000983	Sulfatase; Region: Sulfatase; pfam00884
583355000984	Right handed beta helix region; Region: Beta_helix; pfam13229
583355000985	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
583355000986	putative active site [active]
583355000987	putative metal binding site [ion binding]; other site
583355000988	Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178
583355000989	calcium binding site [ion binding]; other site
583355000990	active site
583355000991	catalytic residues [active]
583355000992	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355000993	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355000994	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
583355000995	substrate binding site; other site
583355000996	dimer interface; other site
583355000997	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
583355000998	active site
583355000999	dimer interface [polypeptide binding]; other site
583355001000	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
583355001001	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
583355001002	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
583355001003	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
583355001004	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
583355001005	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
583355001006	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
583355001007	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
583355001008	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
583355001009	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
583355001010	active site
583355001011	catalytic residues [active]
583355001012	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
583355001013	Transcriptional regulator [Transcription]; Region: IclR; COG1414
583355001014	Bacterial transcriptional regulator; Region: IclR; pfam01614
583355001015	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
583355001016	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
583355001017	active site pocket [active]
583355001018	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
583355001019	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
583355001020	NAD binding site [chemical binding]; other site
583355001021	catalytic residues [active]
583355001022	substrate binding site [chemical binding]; other site
583355001023	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
583355001024	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
583355001025	active site
583355001026	metal binding site [ion binding]; metal-binding site
583355001027	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
583355001028	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
583355001029	Transcriptional regulator [Transcription]; Region: IclR; COG1414
583355001030	Bacterial transcriptional regulator; Region: IclR; pfam01614
583355001031	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
583355001032	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
583355001033	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
583355001034	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
583355001035	DctM-like transporters; Region: DctM; pfam06808
583355001036	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
583355001037	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
583355001038	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
583355001039	Helix-turn-helix domain; Region: HTH_18; pfam12833
583355001040	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001041	D-mannonate oxidoreductase; Provisional; Region: PRK08277
583355001042	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355001043	NAD(P) binding site [chemical binding]; other site
583355001044	active site
583355001045	mannonate dehydratase; Provisional; Region: PRK03906
583355001046	mannonate dehydratase; Region: uxuA; TIGR00695
583355001047	Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295
583355001048	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
583355001049	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
583355001050	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355001051	Sulfatase; Region: Sulfatase; cl17466
583355001052	Sulfatase; Region: Sulfatase; cl17466
583355001053	Sulfatase; Region: Sulfatase; cl17466
583355001054	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355001055	Domain of unknown function (DUF303); Region: DUF303; pfam03629
583355001056	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355001057	Sulfatase; Region: Sulfatase; pfam00884
583355001058	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
583355001059	active site
583355001060	catalytic residues [active]
583355001061	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
583355001062	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
583355001063	Walker A/P-loop; other site
583355001064	ATP binding site [chemical binding]; other site
583355001065	Q-loop/lid; other site
583355001066	ABC transporter signature motif; other site
583355001067	Walker B; other site
583355001068	D-loop; other site
583355001069	H-loop/switch region; other site
583355001070	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
583355001071	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
583355001072	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
583355001073	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
583355001074	Cupin domain; Region: Cupin_2; cl17218
583355001075	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355001076	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001077	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355001078	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355001079	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
583355001080	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
583355001081	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355001082	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355001083	Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790
583355001084	Sulfatase; Region: Sulfatase; cl17466
583355001085	Sulfatase; Region: Sulfatase; cl17466
583355001086	Sulfatase; Region: Sulfatase; cl17466
583355001087	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355001088	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
583355001089	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
583355001090	putative metal binding site [ion binding]; other site
583355001091	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
583355001092	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
583355001093	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
583355001094	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
583355001095	Acyl dehydratase [Lipid metabolism]; Region: MaoC; COG2030
583355001096	active site 2 [active]
583355001097	active site 1 [active]
583355001098	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
583355001099	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355001100	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001101	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355001102	Sulfatase; Region: Sulfatase; pfam00884
583355001103	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
583355001104	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
583355001105	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
583355001106	metal ion-dependent adhesion site (MIDAS); other site
583355001107	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
583355001108	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
583355001109	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
583355001110	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
583355001111	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
583355001112	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
583355001113	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
583355001114	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
583355001115	active site
583355001116	catalytic residues [active]
583355001117	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355001118	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
583355001119	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
583355001120	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
583355001121	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
583355001122	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355001123	C factor cell-cell signaling protein; Provisional; Region: PRK09009
583355001124	NAD(P) binding site [chemical binding]; other site
583355001125	active site
583355001126	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
583355001127	Asp-box motif; other site
583355001128	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
583355001129	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
583355001130	Coenzyme A binding pocket [chemical binding]; other site
583355001131	Histidine kinase; Region: HisKA_3; pfam07730
583355001132	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
583355001133	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355001134	ATP binding site [chemical binding]; other site
583355001135	Mg2+ binding site [ion binding]; other site
583355001136	G-X-G motif; other site
583355001137	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
583355001138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355001139	active site
583355001140	phosphorylation site [posttranslational modification]
583355001141	intermolecular recognition site; other site
583355001142	dimerization interface [polypeptide binding]; other site
583355001143	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
583355001144	DNA binding residues [nucleotide binding]
583355001145	dimerization interface [polypeptide binding]; other site
583355001146	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
583355001147	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
583355001148	putative metal binding site [ion binding]; other site
583355001149	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
583355001150	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
583355001151	sugar binding site [chemical binding]; other site
583355001152	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355001153	Sulfatase; Region: Sulfatase; cl17466
583355001154	Sulfatase; Region: Sulfatase; cl17466
583355001155	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355001156	Sulfatase; Region: Sulfatase; cl17466
583355001157	Sulfatase; Region: Sulfatase; cl17466
583355001158	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355001159	Sulfatase; Region: Sulfatase; pfam00884
583355001160	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
583355001161	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
583355001162	putative metal binding site [ion binding]; other site
583355001163	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
583355001164	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
583355001165	sugar binding site [chemical binding]; other site
583355001166	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355001167	Sulfatase; Region: Sulfatase; pfam00884
583355001168	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355001169	Sulfatase; Region: Sulfatase; pfam00884
583355001170	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
583355001171	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
583355001172	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
583355001173	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
583355001174	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
583355001175	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
583355001176	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
583355001177	putative metal binding site [ion binding]; other site
583355001178	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
583355001179	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
583355001180	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355001181	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355001182	Methane oxygenase PmoA; Region: PmoA; pfam14100
583355001183	Helix-turn-helix domain; Region: HTH_18; pfam12833
583355001184	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001185	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
583355001186	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
583355001187	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
583355001188	putative substrate translocation pore; other site
583355001189	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
583355001190	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
583355001191	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
583355001192	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355001193	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
583355001194	NAD(P) binding site [chemical binding]; other site
583355001195	active site
583355001196	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
583355001197	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
583355001198	active site
583355001199	catalytic tetrad [active]
583355001200	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355001201	Sulfatase; Region: Sulfatase; cl17466
583355001202	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
583355001203	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
583355001204	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
583355001205	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
583355001206	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355001207	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001208	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
583355001209	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
583355001210	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001211	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355001212	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001213	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
583355001214	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
583355001215	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
583355001216	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
583355001217	putative substrate translocation pore; other site
583355001218	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355001219	Sulfatase; Region: Sulfatase; pfam00884
583355001220	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
583355001221	active site
583355001222	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
583355001223	Transcriptional regulators [Transcription]; Region: PurR; COG1609
583355001224	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
583355001225	DNA binding site [nucleotide binding]
583355001226	domain linker motif; other site
583355001227	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
583355001228	ligand binding site [chemical binding]; other site
583355001229	dimerization interface [polypeptide binding]; other site
583355001230	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
583355001231	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
583355001232	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
583355001233	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
583355001234	Alginate lyase; Region: Alginate_lyase; pfam05426
583355001235	active site
583355001236	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
583355001237	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
583355001238	active site
583355001239	trimer interface [polypeptide binding]; other site
583355001240	allosteric site; other site
583355001241	active site lid [active]
583355001242	hexamer (dimer of trimers) interface [polypeptide binding]; other site
583355001243	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
583355001244	nucleoside transporter; Region: 2A0110; TIGR00889
583355001245	MFS_1 like family; Region: MFS_1_like; pfam12832
583355001246	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
583355001247	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
583355001248	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
583355001249	Metal-binding active site; metal-binding site
583355001250	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355001251	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355001252	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
583355001253	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355001254	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355001255	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
583355001256	PAS fold; Region: PAS_4; pfam08448
583355001257	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
583355001258	putative active site [active]
583355001259	heme pocket [chemical binding]; other site
583355001260	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001261	Helix-turn-helix domain; Region: HTH_18; pfam12833
583355001262	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001263	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
583355001264	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001265	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355001266	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001267	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
583355001268	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355001269	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355001270	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
583355001271	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001272	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001273	Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178
583355001274	calcium binding site [ion binding]; other site
583355001275	active site
583355001276	catalytic residues [active]
583355001277	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
583355001278	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355001279	active site
583355001280	phosphorylation site [posttranslational modification]
583355001281	intermolecular recognition site; other site
583355001282	dimerization interface [polypeptide binding]; other site
583355001283	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
583355001284	DNA binding residues [nucleotide binding]
583355001285	dimerization interface [polypeptide binding]; other site
583355001286	Histidine kinase; Region: HisKA_3; pfam07730
583355001287	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355001288	ATP binding site [chemical binding]; other site
583355001289	Mg2+ binding site [ion binding]; other site
583355001290	G-X-G motif; other site
583355001291	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355001292	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355001293	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
583355001294	Domain of unknown function (DUF3859); Region: DUF3859; pfam12975
583355001295	sugar binding site [chemical binding]; other site
583355001296	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
583355001297	Oxygen tolerance; Region: BatD; pfam13584
583355001298	von Willebrand factor type A domain; Region: VWA_2; pfam13519
583355001299	metal ion-dependent adhesion site (MIDAS); other site
583355001300	Aerotolerance regulator N-terminal; Region: BatA; cl06567
583355001301	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
583355001302	metal ion-dependent adhesion site (MIDAS); other site
583355001303	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
583355001304	Protein of unknown function DUF58; Region: DUF58; pfam01882
583355001305	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
583355001306	metal ion-dependent adhesion site (MIDAS); other site
583355001307	MoxR-like ATPases [General function prediction only]; Region: COG0714
583355001308	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
583355001309	Walker A motif; other site
583355001310	ATP binding site [chemical binding]; other site
583355001311	Walker B motif; other site
583355001312	arginine finger; other site
583355001313	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
583355001314	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
583355001315	heme-binding residues [chemical binding]; other site
583355001316	HEAT repeats; Region: HEAT_2; pfam13646
583355001317	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
583355001318	binding surface
583355001319	TPR motif; other site
583355001320	TPR repeat; Region: TPR_11; pfam13414
583355001321	Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129
583355001322	putative active site [active]
583355001323	putative catalytic site [active]
583355001324	Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130
583355001325	PLD-like domain; Region: PLDc_2; pfam13091
583355001326	putative active site [active]
583355001327	putative catalytic site [active]
583355001328	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
583355001329	Transcriptional regulators [Transcription]; Region: PurR; COG1609
583355001330	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355001331	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001332	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355001333	Sulfatase; Region: Sulfatase; pfam00884
583355001334	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355001335	Sulfatase; Region: Sulfatase; pfam00884
583355001336	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
583355001337	active site
583355001338	catalytic residues [active]
583355001339	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355001340	Sulfatase; Region: Sulfatase; pfam00884
583355001341	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
583355001342	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
583355001343	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355001344	Sulfatase; Region: Sulfatase; pfam00884
583355001345	Sulfatase; Region: Sulfatase; cl17466
583355001346	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355001347	Sulfatase; Region: Sulfatase; cl17466
583355001348	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
583355001349	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
583355001350	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
583355001351	Predicted peptidase [General function prediction only]; Region: COG4099
583355001352	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
583355001353	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
583355001354	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
583355001355	Glycosyl hydrolase 43-like family consists of hypothetical proteins; Region: GH43_like_2; cd08994
583355001356	active site
583355001357	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
583355001358	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
583355001359	sugar binding site [chemical binding]; other site
583355001360	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
583355001361	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
583355001362	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
583355001363	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
583355001364	Anti-sigma-K factor rskA; Region: RskA; pfam10099
583355001365	FecR protein; Region: FecR; pfam04773
583355001366	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
583355001367	sugar binding site [chemical binding]; other site
583355001368	RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989
583355001369	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
583355001370	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
583355001371	catalytic tetrad [active]
583355001372	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
583355001373	active site
583355001374	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
583355001375	S1 domain; Region: S1_2; pfam13509
583355001376	S1 domain; Region: S1_2; pfam13509
583355001377	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
583355001378	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
583355001379	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
583355001380	substrate binding site [chemical binding]; other site
583355001381	ATP binding site [chemical binding]; other site
583355001382	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
583355001383	Flavodoxin; Region: Flavodoxin_1; pfam00258
583355001384	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
583355001385	FAD binding pocket [chemical binding]; other site
583355001386	FAD binding motif [chemical binding]; other site
583355001387	catalytic residues [active]
583355001388	NAD binding pocket [chemical binding]; other site
583355001389	phosphate binding motif [ion binding]; other site
583355001390	beta-alpha-beta structure motif; other site
583355001391	sulfite reductase subunit beta; Provisional; Region: PRK13504
583355001392	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
583355001393	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
583355001394	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355001395	Sulfatase; Region: Sulfatase; cl17466
583355001396	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355001397	Sulfatase; Region: Sulfatase; pfam00884
583355001398	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
583355001399	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
583355001400	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
583355001401	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
583355001402	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
583355001403	Walker A/P-loop; other site
583355001404	ATP binding site [chemical binding]; other site
583355001405	Q-loop/lid; other site
583355001406	ABC transporter signature motif; other site
583355001407	Walker B; other site
583355001408	D-loop; other site
583355001409	H-loop/switch region; other site
583355001410	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
583355001411	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
583355001412	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
583355001413	active site
583355001414	catalytic residues [active]
583355001415	Right handed beta helix region; Region: Beta_helix; pfam13229
583355001416	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
583355001417	putative metal binding site [ion binding]; other site
583355001418	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355001419	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355001420	PAS fold; Region: PAS_4; pfam08448
583355001421	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355001422	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001423	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355001424	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355001425	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355001426	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355001427	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
583355001428	Right handed beta helix region; Region: Beta_helix; pfam13229
583355001429	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
583355001430	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355001431	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355001432	CHRD domain; Region: CHRD; pfam07452
583355001433	Trehalose utilisation; Region: ThuA; pfam06283
583355001434	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
583355001435	FOG: PKD repeat [General function prediction only]; Region: COG3291
583355001436	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
583355001437	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
583355001438	ligand binding site [chemical binding]; other site
583355001439	metal binding site [ion binding]; metal-binding site
583355001440	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
583355001441	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
583355001442	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
583355001443	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
583355001444	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
583355001445	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
583355001446	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
583355001447	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355001448	dimer interface [polypeptide binding]; other site
583355001449	phosphorylation site [posttranslational modification]
583355001450	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355001451	ATP binding site [chemical binding]; other site
583355001452	Mg2+ binding site [ion binding]; other site
583355001453	G-X-G motif; other site
583355001454	Response regulator receiver domain; Region: Response_reg; pfam00072
583355001455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355001456	active site
583355001457	phosphorylation site [posttranslational modification]
583355001458	intermolecular recognition site; other site
583355001459	dimerization interface [polypeptide binding]; other site
583355001460	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
583355001461	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355001462	dimer interface [polypeptide binding]; other site
583355001463	phosphorylation site [posttranslational modification]
583355001464	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355001465	ATP binding site [chemical binding]; other site
583355001466	Mg2+ binding site [ion binding]; other site
583355001467	G-X-G motif; other site
583355001468	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
583355001469	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
583355001470	transmembrane helices; other site
583355001471	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
583355001472	TrkA-C domain; Region: TrkA_C; pfam02080
583355001473	TrkA-C domain; Region: TrkA_C; pfam02080
583355001474	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
583355001475	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
583355001476	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
583355001477	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
583355001478	Subunit I/III interface [polypeptide binding]; other site
583355001479	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
583355001480	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
583355001481	D-pathway; other site
583355001482	Putative ubiquinol binding site [chemical binding]; other site
583355001483	Low-spin heme (heme b) binding site [chemical binding]; other site
583355001484	Putative water exit pathway; other site
583355001485	Binuclear center (heme o3/CuB) [ion binding]; other site
583355001486	K-pathway; other site
583355001487	Putative proton exit pathway; other site
583355001488	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
583355001489	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
583355001490	Cytochrome c; Region: Cytochrom_C; pfam00034
583355001491	Protein of unknown function (DUF420); Region: DUF420; pfam04238
583355001492	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
583355001493	UbiA prenyltransferase family; Region: UbiA; pfam01040
583355001494	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
583355001495	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
583355001496	Protein of unknown function (DUF3302); Region: DUF3302; pfam11742
583355001497	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
583355001498	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
583355001499	HlyD family secretion protein; Region: HlyD_3; pfam13437
583355001500	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
583355001501	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
583355001502	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
583355001503	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
583355001504	Major Facilitator Superfamily; Region: MFS_1; pfam07690
583355001505	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
583355001506	catalytic residues [active]
583355001507	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
583355001508	Domain of unknown function DUF59; Region: DUF59; cl00941
583355001509	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
583355001510	Predicted permease [General function prediction only]; Region: COG2985
583355001511	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
583355001512	TrkA-C domain; Region: TrkA_C; pfam02080
583355001513	TrkA-C domain; Region: TrkA_C; pfam02080
583355001514	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
583355001515	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
583355001516	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
583355001517	oligomer interface [polypeptide binding]; other site
583355001518	active site
583355001519	metal binding site [ion binding]; metal-binding site
583355001520	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
583355001521	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
583355001522	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
583355001523	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
583355001524	O-Antigen ligase; Region: Wzy_C; pfam04932
583355001525	DJ-1 family protein; Region: not_thiJ; TIGR01383
583355001526	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
583355001527	conserved cys residue [active]
583355001528	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
583355001529	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
583355001530	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
583355001531	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
583355001532	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
583355001533	pyridoxal 5'-phosphate binding site [chemical binding]; other site
583355001534	homodimer interface [polypeptide binding]; other site
583355001535	catalytic residue [active]
583355001536	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
583355001537	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
583355001538	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
583355001539	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
583355001540	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
583355001541	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
583355001542	PA14 domain; Region: PA14; cl08459
583355001543	PA14 domain; Region: PA14; cl08459
583355001544	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
583355001545	Family description; Region: VCBS; pfam13517
583355001546	Family description; Region: VCBS; pfam13517
583355001547	Family description; Region: VCBS; pfam13517
583355001548	Family description; Region: VCBS; pfam13517
583355001549	Family description; Region: VCBS; pfam13517
583355001550	Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256
583355001551	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
583355001552	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
583355001553	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
583355001554	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
583355001555	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
583355001556	Part of AAA domain; Region: AAA_19; pfam13245
583355001557	Family description; Region: UvrD_C_2; pfam13538
583355001558	salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054
583355001559	chorismate binding enzyme; Region: Chorismate_bind; cl10555
583355001560	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
583355001561	Domain of unknown function (DUF718); Region: DUF718; cl01281
583355001562	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
583355001563	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
583355001564	Catalytic site [active]
583355001565	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
583355001566	Uncharacterized conserved protein [Function unknown]; Region: COG1359
583355001567	4-alpha-glucanotransferase; Provisional; Region: PRK14508
583355001568	Rrf2 family protein; Region: rrf2_super; TIGR00738
583355001569	Transcriptional regulator; Region: Rrf2; pfam02082
583355001570	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
583355001571	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355001572	ATP binding site [chemical binding]; other site
583355001573	Mg2+ binding site [ion binding]; other site
583355001574	G-X-G motif; other site
583355001575	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
583355001576	anchoring element; other site
583355001577	dimer interface [polypeptide binding]; other site
583355001578	ATP binding site [chemical binding]; other site
583355001579	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
583355001580	active site
583355001581	putative metal-binding site [ion binding]; other site
583355001582	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
583355001583	GxxExxY protein; Region: GxxExxY; TIGR04256
583355001584	DNA gyrase subunit A; Validated; Region: PRK05560
583355001585	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
583355001586	CAP-like domain; other site
583355001587	active site
583355001588	primary dimer interface [polypeptide binding]; other site
583355001589	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
583355001590	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
583355001591	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
583355001592	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
583355001593	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
583355001594	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
583355001595	putative active site [active]
583355001596	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
583355001597	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
583355001598	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
583355001599	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
583355001600	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
583355001601	active site
583355001602	HIGH motif; other site
583355001603	nucleotide binding site [chemical binding]; other site
583355001604	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
583355001605	KMSKS motif; other site
583355001606	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
583355001607	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
583355001608	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
583355001609	active site
583355001610	HIGH motif; other site
583355001611	KMSKS motif; other site
583355001612	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
583355001613	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355001614	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355001615	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
583355001616	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
583355001617	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
583355001618	DNA interaction; other site
583355001619	active site
583355001620	metal binding site [ion binding]; metal-binding site
583355001621	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258
583355001622	dimerization interface [polypeptide binding]; other site
583355001623	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
583355001624	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
583355001625	RNA binding surface [nucleotide binding]; other site
583355001626	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355001627	S-adenosylmethionine binding site [chemical binding]; other site
583355001628	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
583355001629	ATP-NAD kinase; Region: NAD_kinase; pfam01513
583355001630	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
583355001631	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
583355001632	active site
583355001633	NTP binding site [chemical binding]; other site
583355001634	metal binding triad [ion binding]; metal-binding site
583355001635	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
583355001636	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
583355001637	Zn2+ binding site [ion binding]; other site
583355001638	Mg2+ binding site [ion binding]; other site
583355001639	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
583355001640	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
583355001641	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001642	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355001643	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001644	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
583355001645	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
583355001646	active site
583355001647	catalytic tetrad [active]
583355001648	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
583355001649	Amidohydrolase; Region: Amidohydro_2; pfam04909
583355001650	active site
583355001651	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
583355001652	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
583355001653	putative NAD(P) binding site [chemical binding]; other site
583355001654	catalytic Zn binding site [ion binding]; other site
583355001655	structural Zn binding site [ion binding]; other site
583355001656	altronate oxidoreductase; Provisional; Region: PRK03643
583355001657	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
583355001658	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
583355001659	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
583355001660	galactarate dehydratase; Region: galactar-dH20; TIGR03248
583355001661	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802
583355001662	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802
583355001663	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
583355001664	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
583355001665	Catalytic domain of Protein Kinases; Region: PKc; cd00180
583355001666	active site
583355001667	ATP binding site [chemical binding]; other site
583355001668	substrate binding site [chemical binding]; other site
583355001669	activation loop (A-loop); other site
583355001670	Surface antigen; Region: Bac_surface_Ag; pfam01103
583355001671	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
583355001672	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
583355001673	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
583355001674	catalytic residues [active]
583355001675	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
583355001676	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
583355001677	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
583355001678	Walker A motif; other site
583355001679	ATP binding site [chemical binding]; other site
583355001680	Walker B motif; other site
583355001681	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
583355001682	Clp protease; Region: CLP_protease; pfam00574
583355001683	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
583355001684	oligomer interface [polypeptide binding]; other site
583355001685	active site residues [active]
583355001686	trigger factor; Region: tig; TIGR00115
583355001687	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
583355001688	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
583355001689	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
583355001690	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355001691	ATP binding site [chemical binding]; other site
583355001692	Mg2+ binding site [ion binding]; other site
583355001693	G-X-G motif; other site
583355001694	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
583355001695	active site
583355001696	shikimate kinase; Reviewed; Region: aroK; PRK00131
583355001697	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
583355001698	ADP binding site [chemical binding]; other site
583355001699	magnesium binding site [ion binding]; other site
583355001700	putative shikimate binding site; other site
583355001701	Bifunctional nuclease; Region: DNase-RNase; pfam02577
583355001702	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
583355001703	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
583355001704	FMN binding site [chemical binding]; other site
583355001705	active site
583355001706	catalytic residues [active]
583355001707	substrate binding site [chemical binding]; other site
583355001708	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
583355001709	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
583355001710	CoA-ligase; Region: Ligase_CoA; pfam00549
583355001711	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
583355001712	CoA binding domain; Region: CoA_binding; smart00881
583355001713	CoA-ligase; Region: Ligase_CoA; pfam00549
583355001714	Methyltransferase domain; Region: Methyltransf_23; pfam13489
583355001715	Methyltransferase domain; Region: Methyltransf_12; pfam08242
583355001716	phosphodiesterase YaeI; Provisional; Region: PRK11340
583355001717	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
583355001718	putative active site [active]
583355001719	putative metal binding site [ion binding]; other site
583355001720	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
583355001721	active site
583355001722	substrate-binding site [chemical binding]; other site
583355001723	metal-binding site [ion binding]
583355001724	GTP binding site [chemical binding]; other site
583355001725	DNA topoisomerase IV subunit A; Provisional; Region: PRK09631
583355001726	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
583355001727	CAP-like domain; other site
583355001728	active site
583355001729	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
583355001730	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
583355001731	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
583355001732	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
583355001733	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
583355001734	Tetramer interface [polypeptide binding]; other site
583355001735	active site
583355001736	FMN-binding site [chemical binding]; other site
583355001737	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
583355001738	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
583355001739	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
583355001740	dihydroorotase; Validated; Region: pyrC; PRK09357
583355001741	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
583355001742	active site
583355001743	CAAX protease self-immunity; Region: Abi; pfam02517
583355001744	hypothetical protein; Provisional; Region: PRK11820
583355001745	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
583355001746	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
583355001747	ACT domain-containing protein [General function prediction only]; Region: COG4747
583355001748	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
583355001749	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
583355001750	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
583355001751	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
583355001752	Glycosyl hydrolase 43-like family consists of hypothetical proteins; Region: GH43_like_2; cd08994
583355001753	active site
583355001754	Transcriptional regulators [Transcription]; Region: PurR; COG1609
583355001755	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
583355001756	DNA binding site [nucleotide binding]
583355001757	domain linker motif; other site
583355001758	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
583355001759	dimerization interface [polypeptide binding]; other site
583355001760	ligand binding site [chemical binding]; other site
583355001761	GTP-binding protein LepA; Provisional; Region: PRK05433
583355001762	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
583355001763	G1 box; other site
583355001764	putative GEF interaction site [polypeptide binding]; other site
583355001765	GTP/Mg2+ binding site [chemical binding]; other site
583355001766	Switch I region; other site
583355001767	G2 box; other site
583355001768	G3 box; other site
583355001769	Switch II region; other site
583355001770	G4 box; other site
583355001771	G5 box; other site
583355001772	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
583355001773	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
583355001774	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
583355001775	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
583355001776	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
583355001777	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
583355001778	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
583355001779	inhibitor-cofactor binding pocket; inhibition site
583355001780	pyridoxal 5'-phosphate binding site [chemical binding]; other site
583355001781	catalytic residue [active]
583355001782	biotin synthase; Region: bioB; TIGR00433
583355001783	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
583355001784	FeS/SAM binding site; other site
583355001785	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
583355001786	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
583355001787	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
583355001788	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
583355001789	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
583355001790	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
583355001791	catalytic residue [active]
583355001792	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
583355001793	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355001794	S-adenosylmethionine binding site [chemical binding]; other site
583355001795	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
583355001796	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
583355001797	active site
583355001798	homodimer interface [polypeptide binding]; other site
583355001799	catalytic site [active]
583355001800	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
583355001801	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
583355001802	Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534
583355001803	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
583355001804	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
583355001805	active site
583355001806	Int/Topo IB signature motif; other site
583355001807	N-acetylglutamate synthase; Validated; Region: PRK05279
583355001808	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
583355001809	substrate binding site [chemical binding]; other site
583355001810	nucleotide binding site [chemical binding]; other site
583355001811	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
583355001812	Coenzyme A binding pocket [chemical binding]; other site
583355001813	PBP superfamily domain; Region: PBP_like_2; cl17296
583355001814	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
583355001815	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355001816	active site
583355001817	phosphorylation site [posttranslational modification]
583355001818	intermolecular recognition site; other site
583355001819	dimerization interface [polypeptide binding]; other site
583355001820	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
583355001821	Walker A motif; other site
583355001822	ATP binding site [chemical binding]; other site
583355001823	Walker B motif; other site
583355001824	arginine finger; other site
583355001825	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
583355001826	MoxR-like ATPases [General function prediction only]; Region: COG0714
583355001827	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
583355001828	Walker A motif; other site
583355001829	ATP binding site [chemical binding]; other site
583355001830	Walker B motif; other site
583355001831	arginine finger; other site
583355001832	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
583355001833	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
583355001834	Protein of unknown function DUF58; Region: DUF58; pfam01882
583355001835	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
583355001836	metal ion-dependent adhesion site (MIDAS); other site
583355001837	von Willebrand factor type A domain; Region: VWA_2; pfam13519
583355001838	metal ion-dependent adhesion site (MIDAS); other site
583355001839	TPR repeat; Region: TPR_11; pfam13414
583355001840	Oxygen tolerance; Region: BatD; pfam13584
583355001841	TPR repeat; Region: TPR_11; pfam13414
583355001842	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
583355001843	binding surface
583355001844	TPR motif; other site
583355001845	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
583355001846	heat shock protein 90; Provisional; Region: PRK05218
583355001847	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355001848	ATP binding site [chemical binding]; other site
583355001849	Mg2+ binding site [ion binding]; other site
583355001850	G-X-G motif; other site
583355001851	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
583355001852	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
583355001853	Adenosylhomocysteinase; Provisional; Region: PTZ00075
583355001854	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
583355001855	homotetramer interface [polypeptide binding]; other site
583355001856	ligand binding site [chemical binding]; other site
583355001857	catalytic site [active]
583355001858	NAD binding site [chemical binding]; other site
583355001859	GxxExxY protein; Region: GxxExxY; TIGR04256
583355001860	S-adenosylmethionine synthetase; Validated; Region: PRK05250
583355001861	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
583355001862	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
583355001863	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
583355001864	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
583355001865	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
583355001866	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
583355001867	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001868	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001869	HEAT repeats; Region: HEAT_2; pfam13646
583355001870	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355001871	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355001872	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355001873	Sulfatase; Region: Sulfatase; pfam00884
583355001874	membrane ATPase/protein kinase; Provisional; Region: PRK09435
583355001875	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
583355001876	Walker A; other site
583355001877	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
583355001878	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
583355001879	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355001880	NAD(P) binding site [chemical binding]; other site
583355001881	active site
583355001882	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
583355001883	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
583355001884	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
583355001885	carboxyltransferase (CT) interaction site; other site
583355001886	biotinylation site [posttranslational modification]; other site
583355001887	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
583355001888	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
583355001889	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
583355001890	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
583355001891	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
583355001892	dimer interface [polypeptide binding]; other site
583355001893	substrate binding site [chemical binding]; other site
583355001894	metal binding site [ion binding]; metal-binding site
583355001895	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
583355001896	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
583355001897	heterodimer interface [polypeptide binding]; other site
583355001898	substrate interaction site [chemical binding]; other site
583355001899	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
583355001900	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
583355001901	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
583355001902	active site
583355001903	substrate binding site [chemical binding]; other site
583355001904	coenzyme B12 binding site [chemical binding]; other site
583355001905	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
583355001906	B12 binding site [chemical binding]; other site
583355001907	cobalt ligand [ion binding]; other site
583355001908	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
583355001909	polyphosphate kinase; Provisional; Region: PRK05443
583355001910	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
583355001911	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
583355001912	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
583355001913	putative domain interface [polypeptide binding]; other site
583355001914	putative active site [active]
583355001915	catalytic site [active]
583355001916	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
583355001917	putative domain interface [polypeptide binding]; other site
583355001918	putative active site [active]
583355001919	catalytic site [active]
583355001920	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
583355001921	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
583355001922	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
583355001923	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
583355001924	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
583355001925	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
583355001926	Active Sites [active]
583355001927	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
583355001928	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
583355001929	N-acetyl-D-glucosamine binding site [chemical binding]; other site
583355001930	catalytic residue [active]
583355001931	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
583355001932	active site
583355001933	catalytic residues [active]
583355001934	ABC transporter ATPase component; Reviewed; Region: PRK11147
583355001935	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
583355001936	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
583355001937	ABC transporter; Region: ABC_tran_2; pfam12848
583355001938	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
583355001939	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
583355001940	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001941	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
583355001942	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
583355001943	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001944	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001945	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
583355001946	Transcriptional regulator [Transcription]; Region: IclR; COG1414
583355001947	Bacterial transcriptional regulator; Region: IclR; pfam01614
583355001948	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
583355001949	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
583355001950	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
583355001951	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
583355001952	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
583355001953	DctM-like transporters; Region: DctM; pfam06808
583355001954	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
583355001955	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355001956	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355001957	HEAT repeats; Region: HEAT_2; pfam13646
583355001958	HEAT repeats; Region: HEAT_2; pfam13646
583355001959	HEAT repeats; Region: HEAT_2; pfam13646
583355001960	Transcriptional regulators [Transcription]; Region: PurR; COG1609
583355001961	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
583355001962	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355001963	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355001964	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
583355001965	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
583355001966	Na binding site [ion binding]; other site
583355001967	Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891
583355001968	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
583355001969	Glycosyl hydrolase 43-like family consists of hypothetical proteins; Region: GH43_like_2; cd08994
583355001970	active site
583355001971	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
583355001972	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
583355001973	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
583355001974	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
583355001975	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355001976	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355001977	Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682
583355001978	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
583355001979	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
583355001980	CysD dimerization site [polypeptide binding]; other site
583355001981	G1 box; other site
583355001982	putative GEF interaction site [polypeptide binding]; other site
583355001983	GTP/Mg2+ binding site [chemical binding]; other site
583355001984	Switch I region; other site
583355001985	G2 box; other site
583355001986	G3 box; other site
583355001987	Switch II region; other site
583355001988	G4 box; other site
583355001989	G5 box; other site
583355001990	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
583355001991	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
583355001992	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
583355001993	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
583355001994	Active Sites [active]
583355001995	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
583355001996	ligand-binding site [chemical binding]; other site
583355001997	TIGR03790 family protein; Region: TIGR03790
583355001998	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
583355001999	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
583355002000	active site
583355002001	metal binding site [ion binding]; metal-binding site
583355002002	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
583355002003	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
583355002004	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
583355002005	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
583355002006	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
583355002007	putative active site [active]
583355002008	PhoH-like protein; Region: PhoH; pfam02562
583355002009	ribonuclease III; Reviewed; Region: rnc; PRK00102
583355002010	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
583355002011	dimerization interface [polypeptide binding]; other site
583355002012	active site
583355002013	metal binding site [ion binding]; metal-binding site
583355002014	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
583355002015	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
583355002016	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
583355002017	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
583355002018	ATP binding site [chemical binding]; other site
583355002019	putative Mg++ binding site [ion binding]; other site
583355002020	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
583355002021	nucleotide binding region [chemical binding]; other site
583355002022	ATP-binding site [chemical binding]; other site
583355002023	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
583355002024	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
583355002025	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
583355002026	active site
583355002027	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
583355002028	nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933
583355002029	SurA N-terminal domain; Region: SurA_N_3; cl07813
583355002030	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
583355002031	Divergent AAA domain; Region: AAA_4; pfam04326
583355002032	enoyl-CoA hydratase; Provisional; Region: PRK06688
583355002033	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
583355002034	substrate binding site [chemical binding]; other site
583355002035	oxyanion hole (OAH) forming residues; other site
583355002036	trimer interface [polypeptide binding]; other site
583355002037	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
583355002038	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
583355002039	dimer interface [polypeptide binding]; other site
583355002040	tetramer interface [polypeptide binding]; other site
583355002041	PYR/PP interface [polypeptide binding]; other site
583355002042	TPP binding site [chemical binding]; other site
583355002043	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
583355002044	TPP-binding site; other site
583355002045	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
583355002046	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
583355002047	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
583355002048	Walker A motif; other site
583355002049	ATP binding site [chemical binding]; other site
583355002050	Walker B motif; other site
583355002051	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355002052	Response regulator receiver domain; Region: Response_reg; pfam00072
583355002053	active site
583355002054	phosphorylation site [posttranslational modification]
583355002055	intermolecular recognition site; other site
583355002056	dimerization interface [polypeptide binding]; other site
583355002057	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
583355002058	Na binding site [ion binding]; other site
583355002059	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
583355002060	MoaE homodimer interface [polypeptide binding]; other site
583355002061	MoaD interaction [polypeptide binding]; other site
583355002062	active site residues [active]
583355002063	MOSC domain; Region: MOSC; pfam03473
583355002064	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
583355002065	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
583355002066	active site
583355002067	HIGH motif; other site
583355002068	KMSKS motif; other site
583355002069	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
583355002070	tRNA binding surface [nucleotide binding]; other site
583355002071	anticodon binding site; other site
583355002072	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
583355002073	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
583355002074	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
583355002075	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
583355002076	putative trimer interface [polypeptide binding]; other site
583355002077	putative CoA binding site [chemical binding]; other site
583355002078	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
583355002079	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
583355002080	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
583355002081	FeS/SAM binding site; other site
583355002082	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
583355002083	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
583355002084	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
583355002085	Protein of unknown function (DUF2851); Region: DUF2851; pfam11013
583355002086	YacP-like NYN domain; Region: NYN_YacP; cl01491
583355002087	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
583355002088	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
583355002089	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
583355002090	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
583355002091	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
583355002092	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
583355002093	transcriptional activator RfaH; Region: RfaH; TIGR01955
583355002094	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
583355002095	heterodimer interface [polypeptide binding]; other site
583355002096	homodimer interface [polypeptide binding]; other site
583355002097	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
583355002098	dimerization interface [polypeptide binding]; other site
583355002099	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355002100	dimer interface [polypeptide binding]; other site
583355002101	phosphorylation site [posttranslational modification]
583355002102	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355002103	ATP binding site [chemical binding]; other site
583355002104	Mg2+ binding site [ion binding]; other site
583355002105	G-X-G motif; other site
583355002106	Response regulator receiver domain; Region: Response_reg; pfam00072
583355002107	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355002108	active site
583355002109	phosphorylation site [posttranslational modification]
583355002110	intermolecular recognition site; other site
583355002111	dimerization interface [polypeptide binding]; other site
583355002112	Family description; Region: VCBS; pfam13517
583355002113	Family description; Region: VCBS; pfam13517
583355002114	Family description; Region: VCBS; pfam13517
583355002115	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
583355002116	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
583355002117	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
583355002118	putative molybdopterin cofactor binding site [chemical binding]; other site
583355002119	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
583355002120	putative molybdopterin cofactor binding site; other site
583355002121	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
583355002122	Predicted esterase [General function prediction only]; Region: COG0627
583355002123	S-formylglutathione hydrolase; Region: PLN02442
583355002124	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
583355002125	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
583355002126	NAD binding site [chemical binding]; other site
583355002127	catalytic Zn binding site [ion binding]; other site
583355002128	substrate binding site [chemical binding]; other site
583355002129	structural Zn binding site [ion binding]; other site
583355002130	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
583355002131	Cytochrome P450; Region: p450; cl12078
583355002132	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
583355002133	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
583355002134	catalytic loop [active]
583355002135	iron binding site [ion binding]; other site
583355002136	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
583355002137	active site
583355002138	catalytic residues [active]
583355002139	Putative Ig domain; Region: He_PIG; pfam05345
583355002140	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
583355002141	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
583355002142	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355002143	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355002144	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
583355002145	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
583355002146	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
583355002147	pyridoxal 5'-phosphate binding site [chemical binding]; other site
583355002148	catalytic residue [active]
583355002149	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
583355002150	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
583355002151	catalytic residue [active]
583355002152	Methyltransferase domain; Region: Methyltransf_23; pfam13489
583355002153	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355002154	S-adenosylmethionine binding site [chemical binding]; other site
583355002155	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
583355002156	phosphoglyceromutase; Provisional; Region: PRK05434
583355002157	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
583355002158	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
583355002159	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
583355002160	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
583355002161	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
583355002162	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
583355002163	active site
583355002164	HIGH motif; other site
583355002165	nucleotide binding site [chemical binding]; other site
583355002166	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
583355002167	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
583355002168	active site
583355002169	KMSKS motif; other site
583355002170	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
583355002171	tRNA binding surface [nucleotide binding]; other site
583355002172	anticodon binding site; other site
583355002173	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
583355002174	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
583355002175	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
583355002176	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
583355002177	FeS/SAM binding site; other site
583355002178	hypothetical protein; Reviewed; Region: PRK00024
583355002179	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
583355002180	MPN+ (JAMM) motif; other site
583355002181	Zinc-binding site [ion binding]; other site
583355002182	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
583355002183	classical (c) SDRs; Region: SDR_c; cd05233
583355002184	NAD(P) binding site [chemical binding]; other site
583355002185	active site
583355002186	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
583355002187	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
583355002188	active site
583355002189	catalytic tetrad [active]
583355002190	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
583355002191	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
583355002192	active site pocket [active]
583355002193	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
583355002194	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
583355002195	putative NAD(P) binding site [chemical binding]; other site
583355002196	catalytic Zn binding site [ion binding]; other site
583355002197	structural Zn binding site [ion binding]; other site
583355002198	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
583355002199	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355002200	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355002201	flavoprotein, HI0933 family; Region: TIGR00275
583355002202	PEP-CTERM motif; Region: VPEP; pfam07589
583355002203	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
583355002204	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
583355002205	active site
583355002206	dimer interface [polypeptide binding]; other site
583355002207	methionine sulfoxide reductase B; Provisional; Region: PRK00222
583355002208	SelR domain; Region: SelR; pfam01641
583355002209	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
583355002210	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
583355002211	Walker A motif; other site
583355002212	ATP binding site [chemical binding]; other site
583355002213	Walker B motif; other site
583355002214	arginine finger; other site
583355002215	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
583355002216	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
583355002217	glycogen branching enzyme; Provisional; Region: PRK05402
583355002218	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
583355002219	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
583355002220	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
583355002221	active site
583355002222	catalytic site [active]
583355002223	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
583355002224	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
583355002225	Organic solvent tolerance protein; Region: OstA_C; pfam04453
583355002226	ScpA/B protein; Region: ScpA_ScpB; cl00598
583355002227	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
583355002228	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
583355002229	catalytic residues [active]
583355002230	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
583355002231	homotrimer interaction site [polypeptide binding]; other site
583355002232	putative active site [active]
583355002233	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
583355002234	homotrimer interaction site [polypeptide binding]; other site
583355002235	putative active site [active]
583355002236	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
583355002237	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
583355002238	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
583355002239	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
583355002240	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
583355002241	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
583355002242	active site
583355002243	catalytic residues [active]
583355002244	metal binding site [ion binding]; metal-binding site
583355002245	homodimer binding site [polypeptide binding]; other site
583355002246	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
583355002247	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
583355002248	ATP binding site [chemical binding]; other site
583355002249	putative Mg++ binding site [ion binding]; other site
583355002250	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
583355002251	nucleotide binding region [chemical binding]; other site
583355002252	ATP-binding site [chemical binding]; other site
583355002253	Helicase associated domain (HA2); Region: HA2; pfam04408
583355002254	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
583355002255	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
583355002256	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
583355002257	putative active site [active]
583355002258	putative metal binding site [ion binding]; other site
583355002259	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
583355002260	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
583355002261	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
583355002262	dimerization interface [polypeptide binding]; other site
583355002263	active site
583355002264	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
583355002265	AAA domain; Region: AAA_30; pfam13604
583355002266	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
583355002267	Transcriptional regulators [Transcription]; Region: PurR; COG1609
583355002268	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
583355002269	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355002270	Transcriptional regulators [Transcription]; Region: PurR; COG1609
583355002271	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
583355002272	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355002273	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355002274	Methane oxygenase PmoA; Region: PmoA; pfam14100
583355002275	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
583355002276	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355002277	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355002278	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355002279	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355002280	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355002281	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355002282	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
583355002283	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
583355002284	Metal-binding active site; metal-binding site
583355002285	Methane oxygenase PmoA; Region: PmoA; pfam14100
583355002286	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355002287	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355002288	Trehalose utilisation; Region: ThuA; pfam06283
583355002289	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
583355002290	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
583355002291	Metal-binding active site; metal-binding site
583355002292	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
583355002293	Transcriptional regulators [Transcription]; Region: PurR; COG1609
583355002294	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355002295	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355002296	Transcriptional regulator [Transcription]; Region: IclR; COG1414
583355002297	Bacterial transcriptional regulator; Region: IclR; pfam01614
583355002298	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
583355002299	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355002300	HEAT repeats; Region: HEAT_2; pfam13646
583355002301	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
583355002302	protein binding surface [polypeptide binding]; other site
583355002303	HEAT repeats; Region: HEAT_2; pfam13646
583355002304	HEAT repeats; Region: HEAT_2; pfam13646
583355002305	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
583355002306	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
583355002307	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
583355002308	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
583355002309	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
583355002310	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
583355002311	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
583355002312	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.   The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153
583355002313	homotrimer interaction site [polypeptide binding]; other site
583355002314	putative active site [active]
583355002315	Cupin domain; Region: Cupin_2; pfam07883
583355002316	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355002317	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355002318	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
583355002319	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
583355002320	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
583355002321	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
583355002322	RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989
583355002323	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
583355002324	DNA binding residues [nucleotide binding]
583355002325	FecR protein; Region: FecR; pfam04773
583355002326	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
583355002327	substrate binding site [chemical binding]; other site
583355002328	active site
583355002329	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
583355002330	metal binding site [ion binding]; metal-binding site
583355002331	ligand binding site [chemical binding]; other site
583355002332	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
583355002333	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
583355002334	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
583355002335	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
583355002336	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
583355002337	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
583355002338	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
583355002339	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
583355002340	vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556
583355002341	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
583355002342	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
583355002343	active site
583355002344	dimer interface [polypeptide binding]; other site
583355002345	effector binding site; other site
583355002346	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
583355002347	TSCPD domain; Region: TSCPD; pfam12637
583355002348	Caspase domain; Region: Peptidase_C14; pfam00656
583355002349	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
583355002350	Transposase; Region: DEDD_Tnp_IS110; pfam01548
583355002351	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
583355002352	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
583355002353	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
583355002354	active site
583355002355	catalytic residues [active]
583355002356	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257
583355002357	PKC phosphorylation site [posttranslational modification]; other site
583355002358	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
583355002359	Transposase; Region: DEDD_Tnp_IS110; pfam01548
583355002360	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
583355002361	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
583355002362	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355002363	active site
583355002364	phosphorylation site [posttranslational modification]
583355002365	intermolecular recognition site; other site
583355002366	dimerization interface [polypeptide binding]; other site
583355002367	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
583355002368	DNA binding residues [nucleotide binding]
583355002369	dimerization interface [polypeptide binding]; other site
583355002370	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
583355002371	Histidine kinase; Region: HisKA_3; pfam07730
583355002372	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355002373	ATP binding site [chemical binding]; other site
583355002374	Mg2+ binding site [ion binding]; other site
583355002375	G-X-G motif; other site
583355002376	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
583355002377	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
583355002378	PKC phosphorylation site [posttranslational modification]; other site
583355002379	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
583355002380	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
583355002381	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
583355002382	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
583355002383	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
583355002384	active site
583355002385	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
583355002386	O-methyltransferase; Region: Methyltransf_2; pfam00891
583355002387	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
583355002388	Domain of unknown function (DUF303); Region: DUF303; pfam03629
583355002389	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
583355002390	PKC phosphorylation site [posttranslational modification]; other site
583355002391	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
583355002392	active site
583355002393	catalytic residues [active]
583355002394	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
583355002395	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
583355002396	Sel1-like repeats; Region: SEL1; smart00671
583355002397	Sel1-like repeats; Region: SEL1; smart00671
583355002398	Sel1-like repeats; Region: SEL1; smart00671
583355002399	Sel1-like repeats; Region: SEL1; smart00671
583355002400	Sel1-like repeats; Region: SEL1; smart00671
583355002401	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
583355002402	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
583355002403	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
583355002404	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
583355002405	Transcriptional regulators [Transcription]; Region: PurR; COG1609
583355002406	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
583355002407	Helix-turn-helix domain; Region: HTH_18; pfam12833
583355002408	Transcriptional regulators [Transcription]; Region: PurR; COG1609
583355002409	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
583355002410	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355002411	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355002412	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
583355002413	active site
583355002414	catalytic residues [active]
583355002415	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
583355002416	Transcriptional regulators [Transcription]; Region: PurR; COG1609
583355002417	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
583355002418	Helix-turn-helix domain; Region: HTH_18; pfam12833
583355002419	Transcriptional regulators [Transcription]; Region: PurR; COG1609
583355002420	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
583355002421	Helix-turn-helix domain; Region: HTH_18; pfam12833
583355002422	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355002423	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
583355002424	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
583355002425	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
583355002426	putative catalytic residues [active]
583355002427	A-macroglobulin complement component; Region: A2M_comp; pfam07678
583355002428	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
583355002429	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
583355002430	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
583355002431	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355002432	dimer interface [polypeptide binding]; other site
583355002433	phosphorylation site [posttranslational modification]
583355002434	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355002435	ATP binding site [chemical binding]; other site
583355002436	Mg2+ binding site [ion binding]; other site
583355002437	G-X-G motif; other site
583355002438	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
583355002439	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
583355002440	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
583355002441	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
583355002442	tandem repeat interface [polypeptide binding]; other site
583355002443	oligomer interface [polypeptide binding]; other site
583355002444	active site residues [active]
583355002445	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
583355002446	tandem repeat interface [polypeptide binding]; other site
583355002447	oligomer interface [polypeptide binding]; other site
583355002448	active site residues [active]
583355002449	methionine sulfoxide reductase A; Provisional; Region: PRK05528
583355002450	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
583355002451	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355002452	Sulfatase; Region: Sulfatase; cl17466
583355002453	Sulfatase; Region: Sulfatase; cl17466
583355002454	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355002455	Sulfatase; Region: Sulfatase; pfam00884
583355002456	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
583355002457	Amidohydrolase; Region: Amidohydro_2; pfam04909
583355002458	Predicted flavoprotein [General function prediction only]; Region: COG0431
583355002459	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
583355002460	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
583355002461	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
583355002462	catalytic motif [active]
583355002463	Zn binding site [ion binding]; other site
583355002464	RibD C-terminal domain; Region: RibD_C; cl17279
583355002465	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
583355002466	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
583355002467	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
583355002468	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
583355002469	TPR motif; other site
583355002470	binding surface
583355002471	TPR repeat; Region: TPR_11; pfam13414
583355002472	integral membrane protein MviN; Region: mviN; TIGR01695
583355002473	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
583355002474	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
583355002475	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
583355002476	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
583355002477	DRTGG domain; Region: DRTGG; pfam07085
583355002478	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
583355002479	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
583355002480	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
583355002481	TPP-binding site; other site
583355002482	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
583355002483	PYR/PP interface [polypeptide binding]; other site
583355002484	dimer interface [polypeptide binding]; other site
583355002485	TPP binding site [chemical binding]; other site
583355002486	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
583355002487	Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636
583355002488	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
583355002489	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
583355002490	HflX GTPase family; Region: HflX; cd01878
583355002491	G1 box; other site
583355002492	GTP/Mg2+ binding site [chemical binding]; other site
583355002493	Switch I region; other site
583355002494	G2 box; other site
583355002495	G3 box; other site
583355002496	Switch II region; other site
583355002497	G4 box; other site
583355002498	G5 box; other site
583355002499	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
583355002500	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
583355002501	P-loop; other site
583355002502	Magnesium ion binding site [ion binding]; other site
583355002503	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
583355002504	Magnesium ion binding site [ion binding]; other site
583355002505	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
583355002506	Catalytic domain of Protein Kinases; Region: PKc; cd00180
583355002507	active site
583355002508	ATP binding site [chemical binding]; other site
583355002509	substrate binding site [chemical binding]; other site
583355002510	activation loop (A-loop); other site
583355002511	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
583355002512	active site
583355002513	Fe-S cluster binding site [ion binding]; other site
583355002514	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
583355002515	Clp amino terminal domain; Region: Clp_N; pfam02861
583355002516	Clp amino terminal domain; Region: Clp_N; pfam02861
583355002517	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
583355002518	Walker A motif; other site
583355002519	ATP binding site [chemical binding]; other site
583355002520	Walker B motif; other site
583355002521	arginine finger; other site
583355002522	UvrB/uvrC motif; Region: UVR; pfam02151
583355002523	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
583355002524	Walker A motif; other site
583355002525	ATP binding site [chemical binding]; other site
583355002526	Walker B motif; other site
583355002527	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
583355002528	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
583355002529	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
583355002530	ADP binding site [chemical binding]; other site
583355002531	phosphagen binding site; other site
583355002532	substrate specificity loop; other site
583355002533	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
583355002534	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
583355002535	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
583355002536	homodimer interface [polypeptide binding]; other site
583355002537	substrate-cofactor binding pocket; other site
583355002538	pyridoxal 5'-phosphate binding site [chemical binding]; other site
583355002539	catalytic residue [active]
583355002540	acetyl-CoA synthetase; Provisional; Region: PRK00174
583355002541	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
583355002542	active site
583355002543	CoA binding site [chemical binding]; other site
583355002544	acyl-activating enzyme (AAE) consensus motif; other site
583355002545	AMP binding site [chemical binding]; other site
583355002546	acetate binding site [chemical binding]; other site
583355002547	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
583355002548	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
583355002549	substrate binding site [chemical binding]; other site
583355002550	glutamase interaction surface [polypeptide binding]; other site
583355002551	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
583355002552	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
583355002553	putative active site [active]
583355002554	metal binding site [ion binding]; metal-binding site
583355002555	homodimer binding site [polypeptide binding]; other site
583355002556	acetolactate synthase; Region: PLN02470
583355002557	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
583355002558	PYR/PP interface [polypeptide binding]; other site
583355002559	dimer interface [polypeptide binding]; other site
583355002560	TPP binding site [chemical binding]; other site
583355002561	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
583355002562	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
583355002563	TPP-binding site [chemical binding]; other site
583355002564	dimer interface [polypeptide binding]; other site
583355002565	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
583355002566	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
583355002567	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
583355002568	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
583355002569	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
583355002570	dimer interface [polypeptide binding]; other site
583355002571	conserved gate region; other site
583355002572	putative PBP binding loops; other site
583355002573	ABC-ATPase subunit interface; other site
583355002574	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
583355002575	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
583355002576	dimer interface [polypeptide binding]; other site
583355002577	conserved gate region; other site
583355002578	putative PBP binding loops; other site
583355002579	ABC-ATPase subunit interface; other site
583355002580	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
583355002581	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
583355002582	Walker A/P-loop; other site
583355002583	ATP binding site [chemical binding]; other site
583355002584	Q-loop/lid; other site
583355002585	ABC transporter signature motif; other site
583355002586	Walker B; other site
583355002587	D-loop; other site
583355002588	H-loop/switch region; other site
583355002589	Protein of unknown function, DUF481; Region: DUF481; pfam04338
583355002590	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
583355002591	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
583355002592	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
583355002593	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
583355002594	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
583355002595	ring oligomerisation interface [polypeptide binding]; other site
583355002596	ATP/Mg binding site [chemical binding]; other site
583355002597	stacking interactions; other site
583355002598	hinge regions; other site
583355002599	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
583355002600	oligomerisation interface [polypeptide binding]; other site
583355002601	mobile loop; other site
583355002602	roof hairpin; other site
583355002603	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
583355002604	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
583355002605	nucleotide binding site [chemical binding]; other site
583355002606	NEF interaction site [polypeptide binding]; other site
583355002607	SBD interface [polypeptide binding]; other site
583355002608	Pathogenicity locus; Region: Cdd1; pfam11731
583355002609	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
583355002610	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
583355002611	Mechanosensitive ion channel; Region: MS_channel; pfam00924
583355002612	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
583355002613	putative rRNA binding site [nucleotide binding]; other site
583355002614	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
583355002615	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
583355002616	TPP-binding site [chemical binding]; other site
583355002617	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
583355002618	2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); Region: sucB; TIGR01347
583355002619	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
583355002620	E3 interaction surface; other site
583355002621	lipoyl attachment site [posttranslational modification]; other site
583355002622	e3 binding domain; Region: E3_binding; pfam02817
583355002623	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
583355002624	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
583355002625	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
583355002626	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
583355002627	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
583355002628	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
583355002629	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
583355002630	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
583355002631	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
583355002632	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
583355002633	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
583355002634	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
583355002635	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
583355002636	NAD binding site [chemical binding]; other site
583355002637	putative substrate binding site 2 [chemical binding]; other site
583355002638	putative substrate binding site 1 [chemical binding]; other site
583355002639	active site
583355002640	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
583355002641	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
583355002642	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
583355002643	DEAD_2; Region: DEAD_2; pfam06733
583355002644	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
583355002645	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
583355002646	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
583355002647	Catalytic site [active]
583355002648	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
583355002649	dimer interface [polypeptide binding]; other site
583355002650	ADP-ribose binding site [chemical binding]; other site
583355002651	active site
583355002652	nudix motif; other site
583355002653	metal binding site [ion binding]; metal-binding site
583355002654	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
583355002655	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
583355002656	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
583355002657	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
583355002658	generic binding surface II; other site
583355002659	generic binding surface I; other site
583355002660	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
583355002661	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
583355002662	substrate binding site [chemical binding]; other site
583355002663	ATP binding site [chemical binding]; other site
583355002664	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
583355002665	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
583355002666	putative catalytic cysteine [active]
583355002667	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
583355002668	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
583355002669	trimerization site [polypeptide binding]; other site
583355002670	active site
583355002671	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
583355002672	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
583355002673	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
583355002674	catalytic residue [active]
583355002675	macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397
583355002676	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
583355002677	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
583355002678	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
583355002679	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
583355002680	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
583355002681	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355002682	S-adenosylmethionine binding site [chemical binding]; other site
583355002683	serine acetyltransferase; Provisional; Region: cysE; PRK11132
583355002684	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
583355002685	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
583355002686	trimer interface [polypeptide binding]; other site
583355002687	active site
583355002688	substrate binding site [chemical binding]; other site
583355002689	CoA binding site [chemical binding]; other site
583355002690	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
583355002691	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
583355002692	TrkA-N domain; Region: TrkA_N; pfam02254
583355002693	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
583355002694	active site
583355002695	phosphorylation site [posttranslational modification]
583355002696	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
583355002697	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
583355002698	Helix-turn-helix domain; Region: HTH_18; pfam12833
583355002699	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355002700	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
583355002701	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
583355002702	substrate binding site [chemical binding]; other site
583355002703	ATP binding site [chemical binding]; other site
583355002704	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
583355002705	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
583355002706	active site
583355002707	intersubunit interface [polypeptide binding]; other site
583355002708	catalytic residue [active]
583355002709	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
583355002710	Protein of unknown function (DUF4013); Region: DUF4013; pfam13197
583355002711	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
583355002712	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
583355002713	substrate binding pocket [chemical binding]; other site
583355002714	chain length determination region; other site
583355002715	substrate-Mg2+ binding site; other site
583355002716	catalytic residues [active]
583355002717	aspartate-rich region 1; other site
583355002718	active site lid residues [active]
583355002719	aspartate-rich region 2; other site
583355002720	Verruc_Plancto-restricted protein; Region: Plancto_Ver_chp; TIGR04138
583355002721	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
583355002722	glycogen synthase; Provisional; Region: glgA; PRK00654
583355002723	ADP-binding pocket [chemical binding]; other site
583355002724	homodimer interface [polypeptide binding]; other site
583355002725	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
583355002726	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
583355002727	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
583355002728	nucleotide binding site/active site [active]
583355002729	HIT family signature motif; other site
583355002730	catalytic residue [active]
583355002731	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
583355002732	PhoH-like protein; Region: PhoH; pfam02562
583355002733	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
583355002734	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
583355002735	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
583355002736	Zn2+ binding site [ion binding]; other site
583355002737	Mg2+ binding site [ion binding]; other site
583355002738	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
583355002739	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
583355002740	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
583355002741	putative acyl-acceptor binding pocket; other site
583355002742	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
583355002743	MASE1; Region: MASE1; cl17823
583355002744	PAS fold; Region: PAS_4; pfam08448
583355002745	GAF domain; Region: GAF; pfam01590
583355002746	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
583355002747	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355002748	dimer interface [polypeptide binding]; other site
583355002749	phosphorylation site [posttranslational modification]
583355002750	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355002751	ATP binding site [chemical binding]; other site
583355002752	Mg2+ binding site [ion binding]; other site
583355002753	G-X-G motif; other site
583355002754	Response regulator receiver domain; Region: Response_reg; pfam00072
583355002755	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355002756	active site
583355002757	phosphorylation site [posttranslational modification]
583355002758	intermolecular recognition site; other site
583355002759	dimerization interface [polypeptide binding]; other site
583355002760	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
583355002761	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
583355002762	putative valine binding site [chemical binding]; other site
583355002763	dimer interface [polypeptide binding]; other site
583355002764	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
583355002765	ketol-acid reductoisomerase; Provisional; Region: PRK05479
583355002766	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
583355002767	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
583355002768	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
583355002769	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
583355002770	domain interfaces; other site
583355002771	active site
583355002772	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
583355002773	active site
583355002774	SAM binding site [chemical binding]; other site
583355002775	homodimer interface [polypeptide binding]; other site
583355002776	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
583355002777	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
583355002778	active site
583355002779	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
583355002780	active site
583355002781	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
583355002782	Conserved TM helix; Region: TM_helix; pfam05552
583355002783	Mechanosensitive ion channel; Region: MS_channel; pfam00924
583355002784	phosphodiesterase YaeI; Provisional; Region: PRK11340
583355002785	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
583355002786	active site
583355002787	metal binding site [ion binding]; metal-binding site
583355002788	Domain of unknown function (DUF4281); Region: DUF4281; pfam14108
583355002789	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
583355002790	ATP binding site [chemical binding]; other site
583355002791	active site
583355002792	substrate binding site [chemical binding]; other site
583355002793	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
583355002794	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
583355002795	nucleotide binding pocket [chemical binding]; other site
583355002796	K-X-D-G motif; other site
583355002797	catalytic site [active]
583355002798	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
583355002799	Helix-hairpin-helix motif; Region: HHH; pfam00633
583355002800	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
583355002801	Dimer interface [polypeptide binding]; other site
583355002802	BRCT sequence motif; other site
583355002803	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
583355002804	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
583355002805	putative active site [active]
583355002806	putative FMN binding site [chemical binding]; other site
583355002807	putative substrate binding site [chemical binding]; other site
583355002808	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
583355002809	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
583355002810	dimer interface [polypeptide binding]; other site
583355002811	PYR/PP interface [polypeptide binding]; other site
583355002812	TPP binding site [chemical binding]; other site
583355002813	substrate binding site [chemical binding]; other site
583355002814	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
583355002815	Domain of unknown function; Region: EKR; pfam10371
583355002816	4Fe-4S binding domain; Region: Fer4; pfam00037
583355002817	4Fe-4S binding domain; Region: Fer4_6; pfam12837
583355002818	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
583355002819	TPP-binding site [chemical binding]; other site
583355002820	dimer interface [polypeptide binding]; other site
583355002821	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
583355002822	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
583355002823	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
583355002824	active site
583355002825	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
583355002826	dimer interface [polypeptide binding]; other site
583355002827	substrate binding site [chemical binding]; other site
583355002828	catalytic residues [active]
583355002829	PAS fold; Region: PAS_4; pfam08448
583355002830	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
583355002831	putative active site [active]
583355002832	heme pocket [chemical binding]; other site
583355002833	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
583355002834	PAS fold; Region: PAS_3; pfam08447
583355002835	putative active site [active]
583355002836	heme pocket [chemical binding]; other site
583355002837	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
583355002838	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
583355002839	putative active site [active]
583355002840	heme pocket [chemical binding]; other site
583355002841	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
583355002842	putative active site [active]
583355002843	heme pocket [chemical binding]; other site
583355002844	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
583355002845	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355002846	dimer interface [polypeptide binding]; other site
583355002847	phosphorylation site [posttranslational modification]
583355002848	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355002849	ATP binding site [chemical binding]; other site
583355002850	Mg2+ binding site [ion binding]; other site
583355002851	G-X-G motif; other site
583355002852	Response regulator receiver domain; Region: Response_reg; pfam00072
583355002853	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355002854	active site
583355002855	phosphorylation site [posttranslational modification]
583355002856	intermolecular recognition site; other site
583355002857	dimerization interface [polypeptide binding]; other site
583355002858	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
583355002859	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
583355002860	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
583355002861	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
583355002862	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
583355002863	metal binding site [ion binding]; metal-binding site
583355002864	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
583355002865	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
583355002866	active site
583355002867	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
583355002868	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
583355002869	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
583355002870	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
583355002871	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
583355002872	substrate binding site [chemical binding]; other site
583355002873	hexamer interface [polypeptide binding]; other site
583355002874	metal binding site [ion binding]; metal-binding site
583355002875	Predicted amidohydrolase [General function prediction only]; Region: COG0388
583355002876	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
583355002877	active site
583355002878	catalytic triad [active]
583355002879	dimer interface [polypeptide binding]; other site
583355002880	CHASE4 domain; Region: CHASE4; cl01308
583355002881	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
583355002882	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355002883	dimer interface [polypeptide binding]; other site
583355002884	phosphorylation site [posttranslational modification]
583355002885	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355002886	ATP binding site [chemical binding]; other site
583355002887	Mg2+ binding site [ion binding]; other site
583355002888	G-X-G motif; other site
583355002889	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
583355002890	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
583355002891	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
583355002892	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
583355002893	RNA binding site [nucleotide binding]; other site
583355002894	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
583355002895	multiple promoter invertase; Provisional; Region: mpi; PRK13413
583355002896	catalytic residues [active]
583355002897	catalytic nucleophile [active]
583355002898	Presynaptic Site I dimer interface [polypeptide binding]; other site
583355002899	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
583355002900	Synaptic Flat tetramer interface [polypeptide binding]; other site
583355002901	Synaptic Site I dimer interface [polypeptide binding]; other site
583355002902	DNA binding site [nucleotide binding]
583355002903	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
583355002904	active site
583355002905	metal binding site [ion binding]; metal-binding site
583355002906	FRG domain; Region: FRG; cl07460
583355002907	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
583355002908	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
583355002909	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
583355002910	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
583355002911	ATP binding site [chemical binding]; other site
583355002912	putative Mg++ binding site [ion binding]; other site
583355002913	UPF0489 domain; Region: UPF0489; pfam12640
583355002914	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355002915	S-adenosylmethionine binding site [chemical binding]; other site
583355002916	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
583355002917	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
583355002918	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
583355002919	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
583355002920	HsdM N-terminal domain; Region: HsdM_N; pfam12161
583355002921	Methyltransferase domain; Region: Methyltransf_26; pfam13659
583355002922	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
583355002923	Radical SAM superfamily; Region: Radical_SAM; pfam04055
583355002924	FeS/SAM binding site; other site
583355002925	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
583355002926	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
583355002927	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
583355002928	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
583355002929	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
583355002930	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
583355002931	active site
583355002932	catalytic residues [active]
583355002933	DNA binding site [nucleotide binding]
583355002934	Int/Topo IB signature motif; other site
583355002935	tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723
583355002936	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
583355002937	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
583355002938	C-terminal peptidase (prc); Region: prc; TIGR00225
583355002939	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
583355002940	protein binding site [polypeptide binding]; other site
583355002941	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
583355002942	Catalytic dyad [active]
583355002943	Uncharacterized conserved protein [Function unknown]; Region: COG1565
583355002944	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
583355002945	cyclase homology domain; Region: CHD; cd07302
583355002946	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
583355002947	nucleotidyl binding site; other site
583355002948	metal binding site [ion binding]; metal-binding site
583355002949	dimer interface [polypeptide binding]; other site
583355002950	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
583355002951	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
583355002952	ATP binding site [chemical binding]; other site
583355002953	putative Mg++ binding site [ion binding]; other site
583355002954	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
583355002955	nucleotide binding region [chemical binding]; other site
583355002956	ATP-binding site [chemical binding]; other site
583355002957	Helicase associated domain (HA2); Region: HA2; pfam04408
583355002958	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
583355002959	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
583355002960	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
583355002961	tetramer interfaces [polypeptide binding]; other site
583355002962	binuclear metal-binding site [ion binding]; other site
583355002963	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
583355002964	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
583355002965	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
583355002966	active site
583355002967	(T/H)XGH motif; other site
583355002968	Major Facilitator Superfamily; Region: MFS_1; pfam07690
583355002969	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
583355002970	putative substrate translocation pore; other site
583355002971	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
583355002972	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
583355002973	fumarate hydratase; Provisional; Region: PRK15389
583355002974	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
583355002975	Fumarase C-terminus; Region: Fumerase_C; pfam05683
583355002976	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
583355002977	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
583355002978	Catalytic domain of Protein Kinases; Region: PKc; cd00180
583355002979	active site
583355002980	ATP binding site [chemical binding]; other site
583355002981	substrate binding site [chemical binding]; other site
583355002982	activation loop (A-loop); other site
583355002983	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
583355002984	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
583355002985	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
583355002986	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
583355002987	GxxExxY protein; Region: GxxExxY; TIGR04256
583355002988	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
583355002989	Ligand Binding Site [chemical binding]; other site
583355002990	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
583355002991	Ligand Binding Site [chemical binding]; other site
583355002992	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
583355002993	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
583355002994	Sulfate transporter family; Region: Sulfate_transp; pfam00916
583355002995	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
583355002996	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
583355002997	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
583355002998	FeS/SAM binding site; other site
583355002999	HemN C-terminal domain; Region: HemN_C; pfam06969
583355003000	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
583355003001	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
583355003002	Walker A/P-loop; other site
583355003003	ATP binding site [chemical binding]; other site
583355003004	Q-loop/lid; other site
583355003005	ABC transporter signature motif; other site
583355003006	Walker B; other site
583355003007	D-loop; other site
583355003008	H-loop/switch region; other site
583355003009	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
583355003010	Domain of unknown function (DUF4250); Region: DUF4250; pfam14056
583355003011	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
583355003012	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
583355003013	Walker A/P-loop; other site
583355003014	ATP binding site [chemical binding]; other site
583355003015	Q-loop/lid; other site
583355003016	ABC transporter signature motif; other site
583355003017	Walker B; other site
583355003018	D-loop; other site
583355003019	H-loop/switch region; other site
583355003020	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
583355003021	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
583355003022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
583355003023	dimer interface [polypeptide binding]; other site
583355003024	conserved gate region; other site
583355003025	putative PBP binding loops; other site
583355003026	ABC-ATPase subunit interface; other site
583355003027	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
583355003028	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
583355003029	dimer interface [polypeptide binding]; other site
583355003030	conserved gate region; other site
583355003031	putative PBP binding loops; other site
583355003032	ABC-ATPase subunit interface; other site
583355003033	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
583355003034	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
583355003035	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
583355003036	active site
583355003037	DNA binding site [nucleotide binding]
583355003038	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
583355003039	putative active site [active]
583355003040	dimerization interface [polypeptide binding]; other site
583355003041	putative tRNAtyr binding site [nucleotide binding]; other site
583355003042	PAS fold; Region: PAS_4; pfam08448
583355003043	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
583355003044	putative active site [active]
583355003045	heme pocket [chemical binding]; other site
583355003046	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
583355003047	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
583355003048	RNA methyltransferase, RsmE family; Region: TIGR00046
583355003049	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
583355003050	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
583355003051	metal binding site 2 [ion binding]; metal-binding site
583355003052	putative DNA binding helix; other site
583355003053	metal binding site 1 [ion binding]; metal-binding site
583355003054	dimer interface [polypeptide binding]; other site
583355003055	structural Zn2+ binding site [ion binding]; other site
583355003056	FeS assembly ATPase SufC; Region: sufC; TIGR01978
583355003057	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
583355003058	Walker A/P-loop; other site
583355003059	ATP binding site [chemical binding]; other site
583355003060	Q-loop/lid; other site
583355003061	ABC transporter signature motif; other site
583355003062	Walker B; other site
583355003063	D-loop; other site
583355003064	H-loop/switch region; other site
583355003065	FeS assembly protein SufB; Region: sufB; TIGR01980
583355003066	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
583355003067	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
583355003068	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
583355003069	FeS assembly protein SufD; Region: sufD; TIGR01981
583355003070	Domain of unknown function DUF59; Region: DUF59; cl00941
583355003071	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
583355003072	ApbE family; Region: ApbE; pfam02424
583355003073	Uncharacterized conserved protein [Function unknown]; Region: COG3379
583355003074	Uncharacterized conserved protein [Function unknown]; Region: COG3379
583355003075	TPR repeat; Region: TPR_11; pfam13414
583355003076	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
583355003077	binding surface
583355003078	TPR motif; other site
583355003079	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
583355003080	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
583355003081	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
583355003082	RDD family; Region: RDD; pfam06271
583355003083	Integral membrane protein DUF95; Region: DUF95; pfam01944
583355003084	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
583355003085	Protein of unknown function DUF58; Region: DUF58; pfam01882
583355003086	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
583355003087	metal ion-dependent adhesion site (MIDAS); other site
583355003088	MoxR-like ATPases [General function prediction only]; Region: COG0714
583355003089	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
583355003090	Walker A motif; other site
583355003091	ATP binding site [chemical binding]; other site
583355003092	Walker B motif; other site
583355003093	arginine finger; other site
583355003094	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
583355003095	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
583355003096	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
583355003097	Protein of unknown function (DUF975); Region: DUF975; cl10504
583355003098	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
583355003099	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
583355003100	LexA repressor; Validated; Region: PRK00215
583355003101	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
583355003102	Catalytic site [active]
583355003103	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
583355003104	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
583355003105	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
583355003106	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
583355003107	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
583355003108	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355003109	active site
583355003110	phosphorylation site [posttranslational modification]
583355003111	intermolecular recognition site; other site
583355003112	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
583355003113	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
583355003114	active site
583355003115	catalytic tetrad [active]
583355003116	MEKHLA domain; Region: MEKHLA; pfam08670
583355003117	subtilisin-like protease; Provisional; Region: PTZ00262
583355003118	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
583355003119	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
583355003120	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
583355003121	homodimer interface [polypeptide binding]; other site
583355003122	active site
583355003123	TDP-binding site; other site
583355003124	acceptor substrate-binding pocket; other site
583355003125	Nickel-containing superoxide dismutase; Region: Sod_Ni; cl07609
583355003126	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
583355003127	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
583355003128	Cu(I) binding site [ion binding]; other site
583355003129	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
583355003130	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355003131	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355003132	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
583355003133	putative metal binding site [ion binding]; other site
583355003134	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257
583355003135	PKC phosphorylation site [posttranslational modification]; other site
583355003136	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
583355003137	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
583355003138	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
583355003139	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
583355003140	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
583355003141	Uncharacterized conserved protein [Function unknown]; Region: COG2308
583355003142	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
583355003143	Protein of unknown function (DUF330); Region: DUF330; pfam03886
583355003144	mce related protein; Region: MCE; pfam02470
583355003145	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
583355003146	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
583355003147	Walker A/P-loop; other site
583355003148	ATP binding site [chemical binding]; other site
583355003149	Q-loop/lid; other site
583355003150	ABC transporter signature motif; other site
583355003151	Walker B; other site
583355003152	D-loop; other site
583355003153	H-loop/switch region; other site
583355003154	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
583355003155	Permease; Region: Permease; pfam02405
583355003156	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
583355003157	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
583355003158	motif II; other site
583355003159	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
583355003160	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
583355003161	motif II; other site
583355003162	Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056
583355003163	DEAD-like helicases superfamily; Region: DEXDc; smart00487
583355003164	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
583355003165	ATP binding site [chemical binding]; other site
583355003166	putative Mg++ binding site [ion binding]; other site
583355003167	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
583355003168	nucleotide binding region [chemical binding]; other site
583355003169	ATP-binding site [chemical binding]; other site
583355003170	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
583355003171	hypothetical protein; Provisional; Region: PRK10318
583355003172	hypothetical protein; Provisional; Region: PRK05421
583355003173	putative catalytic site [active]
583355003174	putative metal binding site [ion binding]; other site
583355003175	putative phosphate binding site [ion binding]; other site
583355003176	primosome assembly protein PriA; Validated; Region: PRK05580
583355003177	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
583355003178	ATP binding site [chemical binding]; other site
583355003179	putative Mg++ binding site [ion binding]; other site
583355003180	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
583355003181	ATP-binding site [chemical binding]; other site
583355003182	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
583355003183	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
583355003184	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
583355003185	Walker A/P-loop; other site
583355003186	ATP binding site [chemical binding]; other site
583355003187	Q-loop/lid; other site
583355003188	ABC transporter signature motif; other site
583355003189	Walker B; other site
583355003190	D-loop; other site
583355003191	H-loop/switch region; other site
583355003192	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
583355003193	TPR motif; other site
583355003194	TPR repeat; Region: TPR_11; pfam13414
583355003195	binding surface
583355003196	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
583355003197	metal binding site 2 [ion binding]; metal-binding site
583355003198	putative DNA binding helix; other site
583355003199	metal binding site 1 [ion binding]; metal-binding site
583355003200	dimer interface [polypeptide binding]; other site
583355003201	structural Zn2+ binding site [ion binding]; other site
583355003202	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
583355003203	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
583355003204	cytoskeletal protein RodZ; Provisional; Region: PRK10856
583355003205	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355003206	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355003207	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
583355003208	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
583355003209	Walker A/P-loop; other site
583355003210	ATP binding site [chemical binding]; other site
583355003211	Q-loop/lid; other site
583355003212	ABC transporter signature motif; other site
583355003213	Walker B; other site
583355003214	D-loop; other site
583355003215	H-loop/switch region; other site
583355003216	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
583355003217	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
583355003218	FtsX-like permease family; Region: FtsX; pfam02687
583355003219	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
583355003220	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
583355003221	non-specific DNA binding site [nucleotide binding]; other site
583355003222	salt bridge; other site
583355003223	sequence-specific DNA binding site [nucleotide binding]; other site
583355003224	HipA N-terminal domain; Region: Couple_hipA; pfam13657
583355003225	HipA-like N-terminal domain; Region: HipA_N; pfam07805
583355003226	HipA-like C-terminal domain; Region: HipA_C; pfam07804
583355003227	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
583355003228	IHF dimer interface [polypeptide binding]; other site
583355003229	IHF - DNA interface [nucleotide binding]; other site
583355003230	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355003231	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355003232	Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390
583355003233	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
583355003234	metal ion-dependent adhesion site (MIDAS); other site
583355003235	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
583355003236	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
583355003237	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
583355003238	purine monophosphate binding site [chemical binding]; other site
583355003239	dimer interface [polypeptide binding]; other site
583355003240	putative catalytic residues [active]
583355003241	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
583355003242	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
583355003243	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
583355003244	conserved repeat domain; Region: B_ant_repeat; TIGR01451
583355003245	Domain of unknown function DUF11; Region: DUF11; cl17728
583355003246	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719
583355003247	Domain of unknown function DUF11; Region: DUF11; cl17728
583355003248	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
583355003249	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
583355003250	active site
583355003251	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
583355003252	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
583355003253	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
583355003254	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
583355003255	Beta-Casp domain; Region: Beta-Casp; pfam10996
583355003256	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
583355003257	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
583355003258	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
583355003259	G1 box; other site
583355003260	putative GEF interaction site [polypeptide binding]; other site
583355003261	GTP/Mg2+ binding site [chemical binding]; other site
583355003262	Switch I region; other site
583355003263	G2 box; other site
583355003264	G3 box; other site
583355003265	Switch II region; other site
583355003266	G4 box; other site
583355003267	G5 box; other site
583355003268	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
583355003269	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
583355003270	Cytochrome c; Region: Cytochrom_C; pfam00034
583355003271	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
583355003272	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
583355003273	active site
583355003274	classical (c) SDRs; Region: SDR_c; cd05233
583355003275	NAD(P) binding site [chemical binding]; other site
583355003276	active site
583355003277	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
583355003278	30S subunit binding site; other site
583355003279	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
583355003280	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355003281	active site
583355003282	phosphorylation site [posttranslational modification]
583355003283	intermolecular recognition site; other site
583355003284	dimerization interface [polypeptide binding]; other site
583355003285	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
583355003286	DNA binding residues [nucleotide binding]
583355003287	dimerization interface [polypeptide binding]; other site
583355003288	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
583355003289	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
583355003290	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
583355003291	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355003292	dimer interface [polypeptide binding]; other site
583355003293	phosphorylation site [posttranslational modification]
583355003294	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355003295	ATP binding site [chemical binding]; other site
583355003296	Mg2+ binding site [ion binding]; other site
583355003297	G-X-G motif; other site
583355003298	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
583355003299	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355003300	active site
583355003301	phosphorylation site [posttranslational modification]
583355003302	intermolecular recognition site; other site
583355003303	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
583355003304	Cupin domain; Region: Cupin_2; pfam07883
583355003305	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
583355003306	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
583355003307	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
583355003308	Walker A motif; other site
583355003309	ATP binding site [chemical binding]; other site
583355003310	Walker B motif; other site
583355003311	Response regulator receiver domain; Region: Response_reg; pfam00072
583355003312	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355003313	active site
583355003314	phosphorylation site [posttranslational modification]
583355003315	intermolecular recognition site; other site
583355003316	dimerization interface [polypeptide binding]; other site
583355003317	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
583355003318	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355003319	active site
583355003320	phosphorylation site [posttranslational modification]
583355003321	intermolecular recognition site; other site
583355003322	dimerization interface [polypeptide binding]; other site
583355003323	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
583355003324	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
583355003325	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
583355003326	protein binding site [polypeptide binding]; other site
583355003327	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
583355003328	protein binding site [polypeptide binding]; other site
583355003329	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
583355003330	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
583355003331	dimer interface [polypeptide binding]; other site
583355003332	active site
583355003333	acyl carrier protein; Provisional; Region: acpP; PRK00982
583355003334	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
583355003335	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355003336	NAD(P) binding site [chemical binding]; other site
583355003337	active site
583355003338	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
583355003339	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
583355003340	RNA binding surface [nucleotide binding]; other site
583355003341	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
583355003342	active site
583355003343	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
583355003344	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
583355003345	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
583355003346	homodimer interface [polypeptide binding]; other site
583355003347	NADP binding site [chemical binding]; other site
583355003348	substrate binding site [chemical binding]; other site
583355003349	RDD family; Region: RDD; pfam06271
583355003350	Response regulator receiver domain; Region: Response_reg; pfam00072
583355003351	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355003352	active site
583355003353	phosphorylation site [posttranslational modification]
583355003354	intermolecular recognition site; other site
583355003355	dimerization interface [polypeptide binding]; other site
583355003356	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
583355003357	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355003358	ATP binding site [chemical binding]; other site
583355003359	G-X-G motif; other site
583355003360	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
583355003361	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
583355003362	Protein of unknown function (DUF721); Region: DUF721; pfam05258
583355003363	thymidylate synthase; Reviewed; Region: thyA; PRK01827
583355003364	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
583355003365	dimerization interface [polypeptide binding]; other site
583355003366	active site
583355003367	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
583355003368	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
583355003369	folate binding site [chemical binding]; other site
583355003370	NADP+ binding site [chemical binding]; other site
583355003371	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
583355003372	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
583355003373	ligand binding site [chemical binding]; other site
583355003374	Protein of unknown function (DUF805); Region: DUF805; cl01224
583355003375	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
583355003376	EamA-like transporter family; Region: EamA; cl17759
583355003377	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
583355003378	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
583355003379	epoxyqueuosine reductase; Region: TIGR00276
583355003380	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
583355003381	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
583355003382	SPFH domain / Band 7 family; Region: Band_7; pfam01145
583355003383	SPFH domain / Band 7 family; Region: Band_7; pfam01145
583355003384	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
583355003385	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355003386	ATP binding site [chemical binding]; other site
583355003387	Mg2+ binding site [ion binding]; other site
583355003388	G-X-G motif; other site
583355003389	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
583355003390	anchoring element; other site
583355003391	dimer interface [polypeptide binding]; other site
583355003392	ATP binding site [chemical binding]; other site
583355003393	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
583355003394	active site
583355003395	putative metal-binding site [ion binding]; other site
583355003396	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
583355003397	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
583355003398	ribonuclease R; Region: RNase_R; TIGR02063
583355003399	RNB domain; Region: RNB; pfam00773
583355003400	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
583355003401	RNA binding site [nucleotide binding]; other site
583355003402	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
583355003403	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
583355003404	transmembrane helices; other site
583355003405	TrkA-C domain; Region: TrkA_C; pfam02080
583355003406	TrkA-C domain; Region: TrkA_C; pfam02080
583355003407	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
583355003408	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
583355003409	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
583355003410	Predicted membrane protein [Function unknown]; Region: COG3174
583355003411	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
583355003412	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
583355003413	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
583355003414	putative substrate binding site [chemical binding]; other site
583355003415	putative ATP binding site [chemical binding]; other site
583355003416	DEAD-like helicases superfamily; Region: DEXDc; smart00487
583355003417	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
583355003418	ATP binding site [chemical binding]; other site
583355003419	putative Mg++ binding site [ion binding]; other site
583355003420	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
583355003421	nucleotide binding region [chemical binding]; other site
583355003422	ATP-binding site [chemical binding]; other site
583355003423	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
583355003424	dimerization interface [polypeptide binding]; other site
583355003425	putative DNA binding site [nucleotide binding]; other site
583355003426	putative Zn2+ binding site [ion binding]; other site
583355003427	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
583355003428	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
583355003429	active site
583355003430	metal binding site [ion binding]; metal-binding site
583355003431	Major Facilitator Superfamily; Region: MFS_1; pfam07690
583355003432	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
583355003433	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
583355003434	putative ligand binding site [chemical binding]; other site
583355003435	putative NAD binding site [chemical binding]; other site
583355003436	catalytic site [active]
583355003437	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
583355003438	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
583355003439	active site
583355003440	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
583355003441	pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555
583355003442	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
583355003443	active site
583355003444	ADP/pyrophosphate binding site [chemical binding]; other site
583355003445	allosteric effector site; other site
583355003446	dimerization interface [polypeptide binding]; other site
583355003447	fructose-1,6-bisphosphate binding site; other site
583355003448	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
583355003449	Fatty acid desaturase; Region: FA_desaturase; pfam00487
583355003450	putative di-iron ligands [ion binding]; other site
583355003451	FAD binding domain; Region: FAD_binding_3; pfam01494
583355003452	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
583355003453	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
583355003454	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
583355003455	RNA binding surface [nucleotide binding]; other site
583355003456	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
583355003457	active site
583355003458	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
583355003459	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
583355003460	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
583355003461	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
583355003462	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
583355003463	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
583355003464	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
583355003465	putative active site [active]
583355003466	heme pocket [chemical binding]; other site
583355003467	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
583355003468	putative active site [active]
583355003469	heme pocket [chemical binding]; other site
583355003470	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355003471	dimer interface [polypeptide binding]; other site
583355003472	phosphorylation site [posttranslational modification]
583355003473	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355003474	ATP binding site [chemical binding]; other site
583355003475	Mg2+ binding site [ion binding]; other site
583355003476	G-X-G motif; other site
583355003477	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
583355003478	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355003479	active site
583355003480	phosphorylation site [posttranslational modification]
583355003481	intermolecular recognition site; other site
583355003482	dimerization interface [polypeptide binding]; other site
583355003483	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
583355003484	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
583355003485	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
583355003486	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
583355003487	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
583355003488	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
583355003489	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
583355003490	apolar tunnel; other site
583355003491	heme binding site [chemical binding]; other site
583355003492	dimerization interface [polypeptide binding]; other site
583355003493	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
583355003494	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
583355003495	Predicted transcriptional regulator [Transcription]; Region: COG1959
583355003496	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
583355003497	DNA-binding site [nucleotide binding]; DNA binding site
583355003498	probable metal-binding protein; Region: matur_matur; TIGR03853
583355003499	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
583355003500	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
583355003501	dimerization interface [polypeptide binding]; other site
583355003502	putative DNA binding site [nucleotide binding]; other site
583355003503	putative Zn2+ binding site [ion binding]; other site
583355003504	Methyltransferase domain; Region: Methyltransf_31; pfam13847
583355003505	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355003506	S-adenosylmethionine binding site [chemical binding]; other site
583355003507	Protein of unknown function, DUF393; Region: DUF393; pfam04134
583355003508	Protein of unknown function (DUF1504); Region: DUF1504; pfam07399
583355003509	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
583355003510	Multisubunit Na+/H+ antiporter, MnhF subunit [Inorganic ion transport and metabolism]; Region: MnhF; COG2212
583355003511	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
583355003512	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
583355003513	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
583355003514	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
583355003515	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509
583355003516	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647
583355003517	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
583355003518	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
583355003519	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
583355003520	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
583355003521	HIGH motif; other site
583355003522	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
583355003523	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
583355003524	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
583355003525	active site
583355003526	KMSKS motif; other site
583355003527	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
583355003528	tRNA binding surface [nucleotide binding]; other site
583355003529	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
583355003530	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
583355003531	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
583355003532	FAD binding site [chemical binding]; other site
583355003533	Protein of unknown function (DUF971); Region: DUF971; pfam06155
583355003534	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
583355003535	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
583355003536	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355003537	dimer interface [polypeptide binding]; other site
583355003538	phosphorylation site [posttranslational modification]
583355003539	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355003540	ATP binding site [chemical binding]; other site
583355003541	Mg2+ binding site [ion binding]; other site
583355003542	G-X-G motif; other site
583355003543	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
583355003544	active site
583355003545	Nsp1-like C-terminal region; Region: Nsp1_C; pfam05064
583355003546	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
583355003547	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
583355003548	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
583355003549	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
583355003550	Walker A/P-loop; other site
583355003551	ATP binding site [chemical binding]; other site
583355003552	Q-loop/lid; other site
583355003553	ABC transporter signature motif; other site
583355003554	Walker B; other site
583355003555	D-loop; other site
583355003556	H-loop/switch region; other site
583355003557	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
583355003558	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355003559	NAD(P) binding site [chemical binding]; other site
583355003560	active site
583355003561	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
583355003562	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
583355003563	GatB domain; Region: GatB_Yqey; smart00845
583355003564	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
583355003565	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
583355003566	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
583355003567	Autotransporter beta-domain; Region: Autotransporter; pfam03797
583355003568	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
583355003569	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
583355003570	putative tRNA-binding site [nucleotide binding]; other site
583355003571	B3/4 domain; Region: B3_4; pfam03483
583355003572	tRNA synthetase B5 domain; Region: B5; smart00874
583355003573	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
583355003574	motif 1; other site
583355003575	dimer interface [polypeptide binding]; other site
583355003576	active site
583355003577	motif 2; other site
583355003578	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
583355003579	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
583355003580	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
583355003581	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
583355003582	dimer interface [polypeptide binding]; other site
583355003583	motif 1; other site
583355003584	active site
583355003585	motif 2; other site
583355003586	motif 3; other site
583355003587	Response regulator receiver domain; Region: Response_reg; pfam00072
583355003588	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355003589	active site
583355003590	phosphorylation site [posttranslational modification]
583355003591	intermolecular recognition site; other site
583355003592	dimerization interface [polypeptide binding]; other site
583355003593	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
583355003594	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
583355003595	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
583355003596	active site
583355003597	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
583355003598	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355003599	dimer interface [polypeptide binding]; other site
583355003600	phosphorylation site [posttranslational modification]
583355003601	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355003602	ATP binding site [chemical binding]; other site
583355003603	Mg2+ binding site [ion binding]; other site
583355003604	G-X-G motif; other site
583355003605	Response regulator receiver domain; Region: Response_reg; pfam00072
583355003606	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355003607	active site
583355003608	phosphorylation site [posttranslational modification]
583355003609	intermolecular recognition site; other site
583355003610	dimerization interface [polypeptide binding]; other site
583355003611	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
583355003612	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
583355003613	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
583355003614	active site
583355003615	(T/H)XGH motif; other site
583355003616	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
583355003617	Transcriptional regulators [Transcription]; Region: PurR; COG1609
583355003618	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
583355003619	Helix-turn-helix domain; Region: HTH_18; pfam12833
583355003620	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355003621	xylose isomerase; Provisional; Region: PRK05474
583355003622	xylose isomerase; Region: xylose_isom_A; TIGR02630
583355003623	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
583355003624	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
583355003625	nucleotide binding site [chemical binding]; other site
583355003626	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
583355003627	nitrite reductase subunit NirD; Provisional; Region: PRK14989
583355003628	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
583355003629	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
583355003630	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
583355003631	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
583355003632	Helix-turn-helix domain; Region: HTH_18; pfam12833
583355003633	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
583355003634	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
583355003635	DNA binding site [nucleotide binding]
583355003636	active site
583355003637	phosphate acetyltransferase; Reviewed; Region: PRK05632
583355003638	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
583355003639	DRTGG domain; Region: DRTGG; pfam07085
583355003640	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
583355003641	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
583355003642	propionate/acetate kinase; Provisional; Region: PRK12379
583355003643	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
583355003644	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355003645	dimer interface [polypeptide binding]; other site
583355003646	phosphorylation site [posttranslational modification]
583355003647	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355003648	ATP binding site [chemical binding]; other site
583355003649	Mg2+ binding site [ion binding]; other site
583355003650	G-X-G motif; other site
583355003651	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
583355003652	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
583355003653	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
583355003654	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
583355003655	Walker A motif; other site
583355003656	ATP binding site [chemical binding]; other site
583355003657	Walker B motif; other site
583355003658	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
583355003659	dihydrodipicolinate synthase; Region: dapA; TIGR00674
583355003660	dimer interface [polypeptide binding]; other site
583355003661	active site
583355003662	catalytic residue [active]
583355003663	dihydrodipicolinate reductase; Provisional; Region: PRK00048
583355003664	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
583355003665	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
583355003666	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
583355003667	RuvA N terminal domain; Region: RuvA_N; pfam01330
583355003668	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
583355003669	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
583355003670	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
583355003671	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
583355003672	DNA binding residues [nucleotide binding]
583355003673	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
583355003674	Putative zinc ribbon domain; Region: DUF164; pfam02591
583355003675	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
583355003676	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
583355003677	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
583355003678	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
583355003679	putative hydrolase; Provisional; Region: PRK02113
583355003680	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
583355003681	putative catalytic site [active]
583355003682	putative metal binding site [ion binding]; other site
583355003683	putative phosphate binding site [ion binding]; other site
583355003684	Peptidase family M48; Region: Peptidase_M48; pfam01435
583355003685	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
583355003686	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
583355003687	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
583355003688	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
583355003689	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
583355003690	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
583355003691	Walker A motif; other site
583355003692	ATP binding site [chemical binding]; other site
583355003693	Walker B motif; other site
583355003694	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
583355003695	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
583355003696	Walker A motif; other site
583355003697	ATP binding site [chemical binding]; other site
583355003698	Walker B motif; other site
583355003699	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
583355003700	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
583355003701	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
583355003702	Walker A motif; other site
583355003703	ATP binding site [chemical binding]; other site
583355003704	Walker B motif; other site
583355003705	transcription termination factor Rho; Provisional; Region: rho; PRK09376
583355003706	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
583355003707	multimer interface [polypeptide binding]; other site
583355003708	Walker A motif; other site
583355003709	ATP binding site [chemical binding]; other site
583355003710	Walker B motif; other site
583355003711	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
583355003712	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
583355003713	CoA-binding site [chemical binding]; other site
583355003714	ATP-binding [chemical binding]; other site
583355003715	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
583355003716	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
583355003717	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
583355003718	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
583355003719	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
583355003720	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355003721	active site
583355003722	phosphorylation site [posttranslational modification]
583355003723	intermolecular recognition site; other site
583355003724	dimerization interface [polypeptide binding]; other site
583355003725	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
583355003726	DNA binding residues [nucleotide binding]
583355003727	dimerization interface [polypeptide binding]; other site
583355003728	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
583355003729	putative active site [active]
583355003730	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
583355003731	putative active site [active]
583355003732	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
583355003733	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
583355003734	ligand binding site [chemical binding]; other site
583355003735	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
583355003736	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
583355003737	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
583355003738	MarR family; Region: MarR_2; pfam12802
583355003739	Domain of unknown function (DUF897); Region: DUF897; pfam05982
583355003740	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
583355003741	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
583355003742	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
583355003743	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
583355003744	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355003745	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355003746	putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485
583355003747	cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488
583355003748	Low-spin heme binding site [chemical binding]; other site
583355003749	D-pathway; other site
583355003750	Putative water exit pathway; other site
583355003751	Binuclear center (active site) [active]
583355003752	K-pathway; other site
583355003753	Putative proton exit pathway; other site
583355003754	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
583355003755	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
583355003756	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
583355003757	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
583355003758	4Fe-4S binding domain; Region: Fer4_5; pfam12801
583355003759	4Fe-4S binding domain; Region: Fer4_3; pfam12798
583355003760	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
583355003761	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
583355003762	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
583355003763	Heavy-metal-associated domain; Region: HMA; pfam00403
583355003764	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
583355003765	Soluble P-type ATPase [General function prediction only]; Region: COG4087
583355003766	Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321
583355003767	lipoyl synthase; Provisional; Region: PRK05481
583355003768	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
583355003769	FeS/SAM binding site; other site
583355003770	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
583355003771	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
583355003772	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
583355003773	quinone interaction residues [chemical binding]; other site
583355003774	active site
583355003775	catalytic residues [active]
583355003776	FMN binding site [chemical binding]; other site
583355003777	substrate binding site [chemical binding]; other site
583355003778	Family description; Region: DsbD_2; pfam13386
583355003779	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
583355003780	Catalytic site [active]
583355003781	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
583355003782	Catalytic site [active]
583355003783	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
583355003784	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355003785	active site
583355003786	phosphorylation site [posttranslational modification]
583355003787	intermolecular recognition site; other site
583355003788	dimerization interface [polypeptide binding]; other site
583355003789	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
583355003790	DNA binding residues [nucleotide binding]
583355003791	dimerization interface [polypeptide binding]; other site
583355003792	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
583355003793	ATP cone domain; Region: ATP-cone; pfam03477
583355003794	Class I ribonucleotide reductase; Region: RNR_I; cd01679
583355003795	active site
583355003796	dimer interface [polypeptide binding]; other site
583355003797	catalytic residues [active]
583355003798	effector binding site; other site
583355003799	R2 peptide binding site; other site
583355003800	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
583355003801	dimer interface [polypeptide binding]; other site
583355003802	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
583355003803	putative radical transfer pathway; other site
583355003804	diiron center [ion binding]; other site
583355003805	tyrosyl radical; other site
583355003806	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
583355003807	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
583355003808	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
583355003809	DNA binding residues [nucleotide binding]
583355003810	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
583355003811	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
583355003812	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
583355003813	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
583355003814	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
583355003815	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
583355003816	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
583355003817	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
583355003818	active site
583355003819	catalytic residues [active]
583355003820	metal binding site [ion binding]; metal-binding site
583355003821	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
583355003822	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
583355003823	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
583355003824	N-terminal plug; other site
583355003825	ligand-binding site [chemical binding]; other site
583355003826	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355003827	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
583355003828	NAD(P) binding site [chemical binding]; other site
583355003829	active site
583355003830	elongation factor G; Reviewed; Region: PRK00007
583355003831	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
583355003832	G1 box; other site
583355003833	putative GEF interaction site [polypeptide binding]; other site
583355003834	GTP/Mg2+ binding site [chemical binding]; other site
583355003835	Switch I region; other site
583355003836	G2 box; other site
583355003837	G3 box; other site
583355003838	Switch II region; other site
583355003839	G4 box; other site
583355003840	G5 box; other site
583355003841	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
583355003842	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
583355003843	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
583355003844	Uncharacterized protein family (UPF0160); Region: UPF0160; cl01749
583355003845	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
583355003846	nudix motif; other site
583355003847	Clostridium thermocellum (Cth)TTM and similar proteins, a subgroup of the CYTH-like superfamily; Region: CYTH-like_CthTTM-like; cd07761
583355003848	putative active site [active]
583355003849	putative metal binding residues [ion binding]; other site
583355003850	signature motif; other site
583355003851	putative dimer interface [polypeptide binding]; other site
583355003852	putative phosphate binding site [ion binding]; other site
583355003853	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
583355003854	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
583355003855	P-loop; other site
583355003856	Magnesium ion binding site [ion binding]; other site
583355003857	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
583355003858	Magnesium ion binding site [ion binding]; other site
583355003859	CHAD domain; Region: CHAD; pfam05235
583355003860	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
583355003861	conserved repeat domain; Region: B_ant_repeat; TIGR01451
583355003862	Domain of unknown function DUF11; Region: DUF11; cl17728
583355003863	Domain of unknown function DUF11; Region: DUF11; cl17728
583355003864	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719
583355003865	Domain of unknown function DUF11; Region: DUF11; cl17728
583355003866	Domain of unknown function DUF11; Region: DUF11; cl17728
583355003867	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
583355003868	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
583355003869	RNA binding site [nucleotide binding]; other site
583355003870	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
583355003871	RNA binding site [nucleotide binding]; other site
583355003872	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
583355003873	RNA binding site [nucleotide binding]; other site
583355003874	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
583355003875	RNA binding site [nucleotide binding]; other site
583355003876	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
583355003877	RNA binding site [nucleotide binding]; other site
583355003878	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
583355003879	RNA binding site [nucleotide binding]; other site
583355003880	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
583355003881	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
583355003882	active site
583355003883	DNA polymerase IV; Validated; Region: PRK02406
583355003884	DNA binding site [nucleotide binding]
583355003885	Trehalose utilisation; Region: ThuA; pfam06283
583355003886	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
583355003887	Mechanosensitive ion channel; Region: MS_channel; pfam00924
583355003888	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
583355003889	GIY-YIG motif/motif A; other site
583355003890	putative active site [active]
583355003891	putative metal binding site [ion binding]; other site
583355003892	hypothetical protein; Provisional; Region: PRK04233
583355003893	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
583355003894	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
583355003895	substrate binding site [chemical binding]; other site
583355003896	active site
583355003897	catalytic residues [active]
583355003898	heterodimer interface [polypeptide binding]; other site
583355003899	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
583355003900	active site
583355003901	phosphorylation site [posttranslational modification]
583355003902	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
583355003903	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
583355003904	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
583355003905	TPR motif; other site
583355003906	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
583355003907	binding surface
583355003908	TPR motif; other site
583355003909	DNA primase; Validated; Region: dnaG; PRK05667
583355003910	CHC2 zinc finger; Region: zf-CHC2; pfam01807
583355003911	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
583355003912	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
583355003913	active site
583355003914	metal binding site [ion binding]; metal-binding site
583355003915	interdomain interaction site; other site
583355003916	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
583355003917	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
583355003918	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
583355003919	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
583355003920	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
583355003921	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
583355003922	DNA binding residues [nucleotide binding]
583355003923	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
583355003924	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
583355003925	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
583355003926	active site
583355003927	SnoaL-like domain; Region: SnoaL_2; pfam12680
583355003928	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
583355003929	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355003930	S-adenosylmethionine binding site [chemical binding]; other site
583355003931	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
583355003932	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
583355003933	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
583355003934	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
583355003935	RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1
583355003936	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
583355003937	DNA binding residues [nucleotide binding]
583355003938	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
583355003939	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
583355003940	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
583355003941	NAD(P) binding site [chemical binding]; other site
583355003942	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
583355003943	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355003944	S-adenosylmethionine binding site [chemical binding]; other site
583355003945	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
583355003946	Fatty acid desaturase; Region: FA_desaturase; pfam00487
583355003947	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
583355003948	Di-iron ligands [ion binding]; other site
583355003949	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
583355003950	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
583355003951	putative hydrophobic ligand binding site [chemical binding]; other site
583355003952	transcription termination factor Rho; Provisional; Region: PRK12608
583355003953	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
583355003954	RNA binding site [nucleotide binding]; other site
583355003955	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
583355003956	Walker A motif; other site
583355003957	ATP binding site [chemical binding]; other site
583355003958	Walker B motif; other site
583355003959	arginine decarboxylase; Provisional; Region: PRK05354
583355003960	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
583355003961	dimer interface [polypeptide binding]; other site
583355003962	active site
583355003963	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
583355003964	catalytic residues [active]
583355003965	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
583355003966	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
583355003967	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
583355003968	lipoyl attachment site [posttranslational modification]; other site
583355003969	PEGA domain; Region: PEGA; pfam08308
583355003970	Domain of unknown function DUF21; Region: DUF21; pfam01595
583355003971	FOG: CBS domain [General function prediction only]; Region: COG0517
583355003972	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
583355003973	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
583355003974	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
583355003975	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
583355003976	dimer interface [polypeptide binding]; other site
583355003977	active site
583355003978	aspartate-rich active site metal binding site; other site
583355003979	allosteric magnesium binding site [ion binding]; other site
583355003980	Schiff base residues; other site
583355003981	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
583355003982	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
583355003983	active site
583355003984	HIGH motif; other site
583355003985	nucleotide binding site [chemical binding]; other site
583355003986	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
583355003987	KMSKS motif; other site
583355003988	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
583355003989	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
583355003990	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
583355003991	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
583355003992	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
583355003993	active site
583355003994	dimer interface [polypeptide binding]; other site
583355003995	motif 1; other site
583355003996	motif 2; other site
583355003997	motif 3; other site
583355003998	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
583355003999	anticodon binding site; other site
583355004000	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985
583355004001	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
583355004002	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
583355004003	generic binding surface I; other site
583355004004	generic binding surface II; other site
583355004005	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
583355004006	Zn2+ binding site [ion binding]; other site
583355004007	Mg2+ binding site [ion binding]; other site
583355004008	Surface antigen; Region: Bac_surface_Ag; pfam01103
583355004009	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
583355004010	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
583355004011	DNA binding site [nucleotide binding]
583355004012	catalytic residue [active]
583355004013	H2TH interface [polypeptide binding]; other site
583355004014	putative catalytic residues [active]
583355004015	turnover-facilitating residue; other site
583355004016	intercalation triad [nucleotide binding]; other site
583355004017	8OG recognition residue [nucleotide binding]; other site
583355004018	putative reading head residues; other site
583355004019	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
583355004020	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
583355004021	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
583355004022	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
583355004023	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
583355004024	dimer interface [polypeptide binding]; other site
583355004025	putative anticodon binding site; other site
583355004026	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
583355004027	motif 1; other site
583355004028	dimer interface [polypeptide binding]; other site
583355004029	active site
583355004030	motif 2; other site
583355004031	motif 3; other site
583355004032	Protein of unknown function (DUF456); Region: DUF456; pfam04306
583355004033	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
583355004034	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
583355004035	Soluble P-type ATPase [General function prediction only]; Region: COG4087
583355004036	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
583355004037	Transcriptional regulators [Transcription]; Region: PurR; COG1609
583355004038	Helix-turn-helix domain; Region: HTH_18; pfam12833
583355004039	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
583355004040	Transcriptional regulators [Transcription]; Region: PurR; COG1609
583355004041	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355004042	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355004043	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355004044	PEP-CTERM motif; Region: VPEP; pfam07589
583355004045	Protein of unknown function (DUF1587); Region: PSD3; pfam07626
583355004046	Protein of unknown function (DUF1595); Region: PSD5; pfam07637
583355004047	Protein of unknown function (DUF1592); Region: PSD4; pfam07631
583355004048	Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627
583355004049	Protein of unknown function (DUF1585); Region: PSD2; pfam07624
583355004050	Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586
583355004051	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
583355004052	DEAD_2; Region: DEAD_2; pfam06733
583355004053	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
583355004054	Protein phosphatase 2C; Region: PP2C; pfam00481
583355004055	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
583355004056	active site
583355004057	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
583355004058	binding surface
583355004059	TPR motif; other site
583355004060	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
583355004061	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
583355004062	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
583355004063	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
583355004064	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
583355004065	probable UDP-glucose 6-dehydrogenase; Region: PLN02353
583355004066	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
583355004067	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
583355004068	fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725
583355004069	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
583355004070	motif II; other site
583355004071	Uncharacterized conserved protein [Function unknown]; Region: COG2928
583355004072	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
583355004073	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
583355004074	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
583355004075	homopentamer interface [polypeptide binding]; other site
583355004076	active site
583355004077	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
583355004078	putative RNA binding site [nucleotide binding]; other site
583355004079	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
583355004080	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
583355004081	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
583355004082	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
583355004083	Walker A/P-loop; other site
583355004084	ATP binding site [chemical binding]; other site
583355004085	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
583355004086	active site
583355004087	dimer interface [polypeptide binding]; other site
583355004088	metal binding site [ion binding]; metal-binding site
583355004089	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
583355004090	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
583355004091	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
583355004092	protein binding site [polypeptide binding]; other site
583355004093	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
583355004094	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
583355004095	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
583355004096	active site
583355004097	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
583355004098	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
583355004099	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
583355004100	trimer interface [polypeptide binding]; other site
583355004101	active site
583355004102	UDP-GlcNAc binding site [chemical binding]; other site
583355004103	lipid binding site [chemical binding]; lipid-binding site
583355004104	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
583355004105	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
583355004106	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
583355004107	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
583355004108	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
583355004109	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
583355004110	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
583355004111	Surface antigen; Region: Bac_surface_Ag; pfam01103
583355004112	replicative DNA helicase; Region: DnaB; TIGR00665
583355004113	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
583355004114	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
583355004115	Walker A motif; other site
583355004116	ATP binding site [chemical binding]; other site
583355004117	Walker B motif; other site
583355004118	DNA binding loops [nucleotide binding]
583355004119	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
583355004120	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
583355004121	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
583355004122	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
583355004123	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
583355004124	dimer interface [polypeptide binding]; other site
583355004125	ssDNA binding site [nucleotide binding]; other site
583355004126	tetramer (dimer of dimers) interface [polypeptide binding]; other site
583355004127	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
583355004128	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
583355004129	putative active site [active]
583355004130	catalytic residue [active]
583355004131	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
583355004132	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
583355004133	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
583355004134	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
583355004135	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
583355004136	Sulfate transporter family; Region: Sulfate_transp; pfam00916
583355004137	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
583355004138	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
583355004139	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
583355004140	active site
583355004141	ATP binding site [chemical binding]; other site
583355004142	substrate binding site [chemical binding]; other site
583355004143	activation loop (A-loop); other site
583355004144	PEGA domain; Region: PEGA; pfam08308
583355004145	Uncharacterized conserved protein [Function unknown]; Region: COG1262
583355004146	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
583355004147	phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313
583355004148	Flavoprotein; Region: Flavoprotein; pfam02441
583355004149	2-isopropylmalate synthase; Validated; Region: PRK03739
583355004150	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
583355004151	active site
583355004152	catalytic residues [active]
583355004153	metal binding site [ion binding]; metal-binding site
583355004154	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
583355004155	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
583355004156	Mechanosensitive ion channel; Region: MS_channel; pfam00924
583355004157	diaminopimelate epimerase; Provisional; Region: PRK13577
583355004158	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
583355004159	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
583355004160	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
583355004161	FAD binding domain; Region: FAD_binding_4; pfam01565
583355004162	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
583355004163	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
583355004164	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
583355004165	Response regulator receiver domain; Region: Response_reg; pfam00072
583355004166	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355004167	active site
583355004168	phosphorylation site [posttranslational modification]
583355004169	intermolecular recognition site; other site
583355004170	dimerization interface [polypeptide binding]; other site
583355004171	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
583355004172	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355004173	dimer interface [polypeptide binding]; other site
583355004174	phosphorylation site [posttranslational modification]
583355004175	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355004176	ATP binding site [chemical binding]; other site
583355004177	Mg2+ binding site [ion binding]; other site
583355004178	G-X-G motif; other site
583355004179	GTP-binding protein YchF; Reviewed; Region: PRK09601
583355004180	YchF GTPase; Region: YchF; cd01900
583355004181	G1 box; other site
583355004182	GTP/Mg2+ binding site [chemical binding]; other site
583355004183	Switch I region; other site
583355004184	G2 box; other site
583355004185	Switch II region; other site
583355004186	G3 box; other site
583355004187	G4 box; other site
583355004188	G5 box; other site
583355004189	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
583355004190	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
583355004191	Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820
583355004192	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
583355004193	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
583355004194	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
583355004195	active site
583355004196	bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188
583355004197	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
583355004198	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
583355004199	signal recognition particle protein; Provisional; Region: PRK10867
583355004200	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
583355004201	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
583355004202	P loop; other site
583355004203	GTP binding site [chemical binding]; other site
583355004204	Signal peptide binding domain; Region: SRP_SPB; pfam02978
583355004205	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
583355004206	active site
583355004207	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
583355004208	homodimer interface [polypeptide binding]; other site
583355004209	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
583355004210	active site pocket [active]
583355004211	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
583355004212	beta-alpha-beta structure motif; other site
583355004213	NAD binding pocket [chemical binding]; other site
583355004214	peptide chain release factor 2; Validated; Region: prfB; PRK00578
583355004215	This domain is found in peptide chain release factors; Region: PCRF; smart00937
583355004216	RF-1 domain; Region: RF-1; pfam00472
583355004217	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
583355004218	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
583355004219	ligand binding site [chemical binding]; other site
583355004220	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
583355004221	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
583355004222	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
583355004223	active site
583355004224	catalytic site [active]
583355004225	PilX N-terminal; Region: PilX_N; pfam14341
583355004226	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
583355004227	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
583355004228	Ligand Binding Site [chemical binding]; other site
583355004229	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
583355004230	active site
583355004231	putative catalytic site [active]
583355004232	DNA binding site [nucleotide binding]
583355004233	putative phosphate binding site [ion binding]; other site
583355004234	metal binding site A [ion binding]; metal-binding site
583355004235	AP binding site [nucleotide binding]; other site
583355004236	metal binding site B [ion binding]; metal-binding site
583355004237	thiamine monophosphate kinase; Provisional; Region: PRK05731
583355004238	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
583355004239	ATP binding site [chemical binding]; other site
583355004240	dimerization interface [polypeptide binding]; other site
583355004241	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
583355004242	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
583355004243	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
583355004244	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
583355004245	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
583355004246	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
583355004247	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
583355004248	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
583355004249	Protein of unknown function DUF58; Region: DUF58; pfam01882
583355004250	MoxR-like ATPases [General function prediction only]; Region: COG0714
583355004251	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
583355004252	Walker A motif; other site
583355004253	ATP binding site [chemical binding]; other site
583355004254	Walker B motif; other site
583355004255	arginine finger; other site
583355004256	Response regulator receiver domain; Region: Response_reg; pfam00072
583355004257	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355004258	active site
583355004259	phosphorylation site [posttranslational modification]
583355004260	intermolecular recognition site; other site
583355004261	dimerization interface [polypeptide binding]; other site
583355004262	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
583355004263	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
583355004264	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
583355004265	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
583355004266	type II secretion system protein D; Region: type_II_gspD; TIGR02517
583355004267	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
583355004268	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
583355004269	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
583355004270	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
583355004271	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
583355004272	pyridoxal 5'-phosphate binding site [chemical binding]; other site
583355004273	homodimer interface [polypeptide binding]; other site
583355004274	catalytic residue [active]
583355004275	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
583355004276	RNA binding surface [nucleotide binding]; other site
583355004277	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
583355004278	homotrimer interaction site [polypeptide binding]; other site
583355004279	zinc binding site [ion binding]; other site
583355004280	CDP-binding sites; other site
583355004281	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
583355004282	active site
583355004283	multimer interface [polypeptide binding]; other site
583355004284	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
583355004285	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
583355004286	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
583355004287	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
583355004288	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
583355004289	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
583355004290	HlyD family secretion protein; Region: HlyD_3; pfam13437
583355004291	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
583355004292	Protein export membrane protein; Region: SecD_SecF; cl14618
583355004293	GxxExxY protein; Region: GxxExxY; TIGR04256
583355004294	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
583355004295	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
583355004296	putative catalytic site [active]
583355004297	putative metal binding site [ion binding]; other site
583355004298	putative phosphate binding site [ion binding]; other site
583355004299	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
583355004300	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
583355004301	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156
583355004302	putative active site [active]
583355004303	catalytic site [active]
583355004304	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162
583355004305	putative active site [active]
583355004306	catalytic site [active]
583355004307	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
583355004308	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
583355004309	peptide binding site [polypeptide binding]; other site
583355004310	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
583355004311	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
583355004312	dimer interface [polypeptide binding]; other site
583355004313	conserved gate region; other site
583355004314	putative PBP binding loops; other site
583355004315	ABC-ATPase subunit interface; other site
583355004316	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
583355004317	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
583355004318	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
583355004319	dimer interface [polypeptide binding]; other site
583355004320	conserved gate region; other site
583355004321	putative PBP binding loops; other site
583355004322	ABC-ATPase subunit interface; other site
583355004323	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355004324	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
583355004325	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
583355004326	NAD(P) binding site [chemical binding]; other site
583355004327	NAD(P) binding site [chemical binding]; other site
583355004328	homodimer interface [polypeptide binding]; other site
583355004329	substrate binding site [chemical binding]; other site
583355004330	active site
583355004331	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
583355004332	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
583355004333	inhibitor-cofactor binding pocket; inhibition site
583355004334	pyridoxal 5'-phosphate binding site [chemical binding]; other site
583355004335	catalytic residue [active]
583355004336	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
583355004337	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
583355004338	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
583355004339	alphaNTD homodimer interface [polypeptide binding]; other site
583355004340	alphaNTD - beta interaction site [polypeptide binding]; other site
583355004341	alphaNTD - beta' interaction site [polypeptide binding]; other site
583355004342	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
583355004343	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
583355004344	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
583355004345	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
583355004346	RNA binding surface [nucleotide binding]; other site
583355004347	30S ribosomal protein S11; Validated; Region: PRK05309
583355004348	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
583355004349	30S ribosomal protein S13; Region: bact_S13; TIGR03631
583355004350	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
583355004351	active site
583355004352	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
583355004353	SecY translocase; Region: SecY; pfam00344
583355004354	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
583355004355	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
583355004356	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
583355004357	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
583355004358	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
583355004359	23S rRNA interface [nucleotide binding]; other site
583355004360	L21e interface [polypeptide binding]; other site
583355004361	5S rRNA interface [nucleotide binding]; other site
583355004362	L27 interface [polypeptide binding]; other site
583355004363	L5 interface [polypeptide binding]; other site
583355004364	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
583355004365	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
583355004366	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
583355004367	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
583355004368	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
583355004369	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
583355004370	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
583355004371	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
583355004372	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
583355004373	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
583355004374	RNA binding site [nucleotide binding]; other site
583355004375	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
583355004376	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
583355004377	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
583355004378	23S rRNA interface [nucleotide binding]; other site
583355004379	putative translocon interaction site; other site
583355004380	signal recognition particle (SRP54) interaction site; other site
583355004381	L23 interface [polypeptide binding]; other site
583355004382	trigger factor interaction site; other site
583355004383	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
583355004384	23S rRNA interface [nucleotide binding]; other site
583355004385	5S rRNA interface [nucleotide binding]; other site
583355004386	putative antibiotic binding site [chemical binding]; other site
583355004387	L25 interface [polypeptide binding]; other site
583355004388	L27 interface [polypeptide binding]; other site
583355004389	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
583355004390	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
583355004391	G-X-X-G motif; other site
583355004392	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
583355004393	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
583355004394	putative translocon binding site; other site
583355004395	protein-rRNA interface [nucleotide binding]; other site
583355004396	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
583355004397	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
583355004398	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
583355004399	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
583355004400	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
583355004401	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
583355004402	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
583355004403	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
583355004404	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
583355004405	dimer interface [polypeptide binding]; other site
583355004406	ssDNA binding site [nucleotide binding]; other site
583355004407	tetramer (dimer of dimers) interface [polypeptide binding]; other site
583355004408	Oxygen tolerance; Region: BatD; pfam13584
583355004409	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
583355004410	von Willebrand factor type A domain; Region: VWA_2; pfam13519
583355004411	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
583355004412	metal ion-dependent adhesion site (MIDAS); other site
583355004413	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
583355004414	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
583355004415	Protein of unknown function DUF58; Region: DUF58; pfam01882
583355004416	MoxR-like ATPases [General function prediction only]; Region: COG0714
583355004417	ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726
583355004418	Walker A motif; other site
583355004419	ATP binding site [chemical binding]; other site
583355004420	Walker B motif; other site
583355004421	arginine finger; other site
583355004422	Uncharacterized conserved protein [Function unknown]; Region: COG5361
583355004423	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
583355004424	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
583355004425	Uncharacterized conserved protein [Function unknown]; Region: COG5361
583355004426	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
583355004427	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
583355004428	Uncharacterized conserved protein [Function unknown]; Region: COG5361
583355004429	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
583355004430	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
583355004431	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
583355004432	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
583355004433	Walker A/P-loop; other site
583355004434	ATP binding site [chemical binding]; other site
583355004435	Q-loop/lid; other site
583355004436	ABC transporter signature motif; other site
583355004437	Walker B; other site
583355004438	D-loop; other site
583355004439	H-loop/switch region; other site
583355004440	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
583355004441	elongation factor G; Reviewed; Region: PRK00007
583355004442	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
583355004443	G1 box; other site
583355004444	putative GEF interaction site [polypeptide binding]; other site
583355004445	GTP/Mg2+ binding site [chemical binding]; other site
583355004446	Switch I region; other site
583355004447	G2 box; other site
583355004448	G3 box; other site
583355004449	Switch II region; other site
583355004450	G4 box; other site
583355004451	G5 box; other site
583355004452	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
583355004453	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
583355004454	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
583355004455	30S ribosomal protein S7; Validated; Region: PRK05302
583355004456	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
583355004457	S17 interaction site [polypeptide binding]; other site
583355004458	S8 interaction site; other site
583355004459	16S rRNA interaction site [nucleotide binding]; other site
583355004460	streptomycin interaction site [chemical binding]; other site
583355004461	23S rRNA interaction site [nucleotide binding]; other site
583355004462	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
583355004463	Mnd1 family; Region: Mnd1; pfam03962
583355004464	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
583355004465	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
583355004466	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
583355004467	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
583355004468	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
583355004469	Walker A/P-loop; other site
583355004470	ATP binding site [chemical binding]; other site
583355004471	Q-loop/lid; other site
583355004472	ABC transporter signature motif; other site
583355004473	Walker B; other site
583355004474	D-loop; other site
583355004475	H-loop/switch region; other site
583355004476	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
583355004477	dimerization domain swap beta strand [polypeptide binding]; other site
583355004478	regulatory protein interface [polypeptide binding]; other site
583355004479	active site
583355004480	regulatory phosphorylation site [posttranslational modification]; other site
583355004481	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
583355004482	TPR motif; other site
583355004483	TPR repeat; Region: TPR_11; pfam13414
583355004484	binding surface
583355004485	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
583355004486	binding surface
583355004487	TPR motif; other site
583355004488	Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931
583355004489	Neurotransmitter-gated ion-channel transmembrane region; Region: Neur_chan_memb; pfam02932
583355004490	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355004491	S-adenosylmethionine binding site [chemical binding]; other site
583355004492	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
583355004493	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
583355004494	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
583355004495	active site
583355004496	catalytic residues [active]
583355004497	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
583355004498	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
583355004499	catalytic triad [active]
583355004500	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
583355004501	catalytic core [active]
583355004502	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
583355004503	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
583355004504	nucleotide binding site [chemical binding]; other site
583355004505	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
583355004506	homodimer interface [polypeptide binding]; other site
583355004507	chemical substrate binding site [chemical binding]; other site
583355004508	oligomer interface [polypeptide binding]; other site
583355004509	metal binding site [ion binding]; metal-binding site
583355004510	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
583355004511	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
583355004512	Ligand binding site; other site
583355004513	Putative Catalytic site; other site
583355004514	DXD motif; other site
583355004515	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
583355004516	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
583355004517	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
583355004518	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
583355004519	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
583355004520	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
583355004521	active site
583355004522	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
583355004523	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
583355004524	active site
583355004525	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
583355004526	MgtE intracellular N domain; Region: MgtE_N; smart00924
583355004527	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
583355004528	Divalent cation transporter; Region: MgtE; pfam01769
583355004529	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
583355004530	nudix motif; other site
583355004531	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
583355004532	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
583355004533	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
583355004534	homodimer interface [polypeptide binding]; other site
583355004535	oligonucleotide binding site [chemical binding]; other site
583355004536	Glycerate kinase family; Region: Gly_kinase; cl00841
583355004537	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
583355004538	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
583355004539	Lamin Tail Domain; Region: LTD; pfam00932
583355004540	CotH protein; Region: CotH; pfam08757
583355004541	Lamin Tail Domain; Region: LTD; pfam00932
583355004542	Lamin Tail Domain; Region: LTD; pfam00932
583355004543	Lamin Tail Domain; Region: LTD; pfam00932
583355004544	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
583355004545	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
583355004546	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
583355004547	L-aspartate oxidase; Provisional; Region: PRK06175
583355004548	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
583355004549	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
583355004550	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
583355004551	putative Iron-sulfur protein interface [polypeptide binding]; other site
583355004552	proximal heme binding site [chemical binding]; other site
583355004553	distal heme binding site [chemical binding]; other site
583355004554	putative dimer interface [polypeptide binding]; other site
583355004555	CTP synthetase; Validated; Region: pyrG; PRK05380
583355004556	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
583355004557	Catalytic site [active]
583355004558	active site
583355004559	UTP binding site [chemical binding]; other site
583355004560	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
583355004561	active site
583355004562	putative oxyanion hole; other site
583355004563	catalytic triad [active]
583355004564	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
583355004565	active site
583355004566	ribulose/triose binding site [chemical binding]; other site
583355004567	phosphate binding site [ion binding]; other site
583355004568	substrate (anthranilate) binding pocket [chemical binding]; other site
583355004569	product (indole) binding pocket [chemical binding]; other site
583355004570	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
583355004571	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
583355004572	S-adenosylmethionine binding site [chemical binding]; other site
583355004573	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
583355004574	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
583355004575	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
583355004576	homotrimer interaction site [polypeptide binding]; other site
583355004577	putative active site [active]
583355004578	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
583355004579	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
583355004580	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
583355004581	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
583355004582	protein binding site [polypeptide binding]; other site
583355004583	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
583355004584	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
583355004585	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
583355004586	Walker A motif; other site
583355004587	ATP binding site [chemical binding]; other site
583355004588	Walker B motif; other site
583355004589	arginine finger; other site
583355004590	Peptidase family M41; Region: Peptidase_M41; pfam01434
583355004591	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
583355004592	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
583355004593	Ligand Binding Site [chemical binding]; other site
583355004594	TilS substrate C-terminal domain; Region: TilS_C; smart00977
583355004595	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
583355004596	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
583355004597	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
583355004598	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
583355004599	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
583355004600	DNA binding residues [nucleotide binding]
583355004601	Uncharacterized conserved protein [Function unknown]; Region: COG2353
583355004602	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
583355004603	putative active site [active]
583355004604	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
583355004605	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
583355004606	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318
583355004607	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
583355004608	Zn2+ binding site [ion binding]; other site
583355004609	Mg2+ binding site [ion binding]; other site
583355004610	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
583355004611	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
583355004612	Carbon starvation protein CstA; Region: CstA; pfam02554
583355004613	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
583355004614	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
583355004615	putative DNA binding site [nucleotide binding]; other site
583355004616	dimerization interface [polypeptide binding]; other site
583355004617	putative Zn2+ binding site [ion binding]; other site
583355004618	Predicted permeases [General function prediction only]; Region: COG0701
583355004619	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
583355004620	four helix bundle protein; Region: TIGR02436
583355004621	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
583355004622	Low molecular weight phosphatase family; Region: LMWPc; cd00115
583355004623	active site
583355004624	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
583355004625	amphipathic channel; other site
583355004626	Asn-Pro-Ala signature motifs; other site
583355004627	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
583355004628	META domain; Region: META; pfam03724
583355004629	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
583355004630	Lumazine binding domain; Region: Lum_binding; pfam00677
583355004631	Lumazine binding domain; Region: Lum_binding; pfam00677
583355004632	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
583355004633	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
583355004634	active site
583355004635	dimerization interface [polypeptide binding]; other site
583355004636	Ion transport protein; Region: Ion_trans; pfam00520
583355004637	Ion channel; Region: Ion_trans_2; pfam07885
583355004638	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
583355004639	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
583355004640	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
583355004641	intersubunit interface [polypeptide binding]; other site
583355004642	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
583355004643	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
583355004644	Walker A/P-loop; other site
583355004645	ATP binding site [chemical binding]; other site
583355004646	Q-loop/lid; other site
583355004647	ABC transporter signature motif; other site
583355004648	Walker B; other site
583355004649	D-loop; other site
583355004650	H-loop/switch region; other site
583355004651	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
583355004652	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
583355004653	ABC-ATPase subunit  interface; other site
583355004654	dimer interface [polypeptide binding]; other site
583355004655	putative PBP binding regions; other site
583355004656	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
583355004657	metal binding site 2 [ion binding]; metal-binding site
583355004658	putative DNA binding helix; other site
583355004659	metal binding site 1 [ion binding]; metal-binding site
583355004660	dimer interface [polypeptide binding]; other site
583355004661	structural Zn2+ binding site [ion binding]; other site
583355004662	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
583355004663	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
583355004664	N-terminal plug; other site
583355004665	ligand-binding site [chemical binding]; other site
583355004666	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
583355004667	Domain of unknown function (DUF3127); Region: DUF3127; pfam11325
583355004668	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
583355004669	Fasciclin domain; Region: Fasciclin; pfam02469
583355004670	Flagellin N-methylase; Region: FliB; cl00497
583355004671	von Willebrand factor; Region: vWF_A; pfam12450
583355004672	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
583355004673	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
583355004674	metal ion-dependent adhesion site (MIDAS); other site
583355004675	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
583355004676	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
583355004677	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
583355004678	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
583355004679	DNA binding residues [nucleotide binding]
583355004680	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
583355004681	AMP-binding enzyme; Region: AMP-binding; pfam00501
583355004682	acyl-activating enzyme (AAE) consensus motif; other site
583355004683	AMP binding site [chemical binding]; other site
583355004684	active site
583355004685	CoA binding site [chemical binding]; other site
583355004686	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
583355004687	GTP1/OBG; Region: GTP1_OBG; pfam01018
583355004688	Obg GTPase; Region: Obg; cd01898
583355004689	G1 box; other site
583355004690	GTP/Mg2+ binding site [chemical binding]; other site
583355004691	Switch I region; other site
583355004692	G2 box; other site
583355004693	G3 box; other site
583355004694	Switch II region; other site
583355004695	G4 box; other site
583355004696	G5 box; other site
583355004697	exopolyphosphatase; Region: exo_poly_only; TIGR03706
583355004698	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
583355004699	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
583355004700	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
583355004701	active site
583355004702	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
583355004703	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
583355004704	active site
583355004705	Riboflavin kinase; Region: Flavokinase; pfam01687
583355004706	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
583355004707	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
583355004708	RNA binding site [nucleotide binding]; other site
583355004709	active site
583355004710	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
583355004711	DHH family; Region: DHH; pfam01368
583355004712	DHHA1 domain; Region: DHHA1; pfam02272
583355004713	Ribosome-binding factor A; Region: RBFA; pfam02033
583355004714	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
583355004715	translation initiation factor IF-2; Region: IF-2; TIGR00487
583355004716	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
583355004717	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
583355004718	G1 box; other site
583355004719	putative GEF interaction site [polypeptide binding]; other site
583355004720	GTP/Mg2+ binding site [chemical binding]; other site
583355004721	Switch I region; other site
583355004722	G2 box; other site
583355004723	G3 box; other site
583355004724	Switch II region; other site
583355004725	G4 box; other site
583355004726	G5 box; other site
583355004727	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
583355004728	Translation-initiation factor 2; Region: IF-2; pfam11987
583355004729	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
583355004730	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
583355004731	NusA N-terminal domain; Region: NusA_N; pfam08529
583355004732	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
583355004733	RNA binding site [nucleotide binding]; other site
583355004734	homodimer interface [polypeptide binding]; other site
583355004735	NusA-like KH domain; Region: KH_5; pfam13184
583355004736	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
583355004737	G-X-X-G motif; other site
583355004738	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
583355004739	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
583355004740	FeS/SAM binding site; other site
583355004741	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
583355004742	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
583355004743	Ligand Binding Site [chemical binding]; other site
583355004744	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
583355004745	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
583355004746	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
583355004747	catalytic residue [active]
583355004748	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
583355004749	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
583355004750	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
583355004751	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
583355004752	amidase catalytic site [active]
583355004753	Zn binding residues [ion binding]; other site
583355004754	substrate binding site [chemical binding]; other site
583355004755	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
583355004756	ACT domain; Region: ACT_6; pfam13740
583355004757	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
583355004758	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
583355004759	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
583355004760	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
583355004761	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
583355004762	Na binding site [ion binding]; other site
583355004763	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
583355004764	diaminopimelate decarboxylase; Provisional; Region: PRK11165
583355004765	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
583355004766	active site
583355004767	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
583355004768	substrate binding site [chemical binding]; other site
583355004769	catalytic residues [active]
583355004770	dimer interface [polypeptide binding]; other site
583355004771	Tic20-like protein; Region: Tic20; pfam09685
583355004772	cytidine deaminase; Provisional; Region: PRK09027
583355004773	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
583355004774	active site
583355004775	catalytic motif [active]
583355004776	Zn binding site [ion binding]; other site
583355004777	Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211
583355004778	histidinol-phosphatase; Provisional; Region: PRK07328
583355004779	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
583355004780	active site
583355004781	dimer interface [polypeptide binding]; other site
583355004782	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
583355004783	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
583355004784	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
583355004785	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
583355004786	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
583355004787	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
583355004788	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
583355004789	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
583355004790	active site
583355004791	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
583355004792	active site
583355004793	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
583355004794	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
583355004795	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
583355004796	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355004797	S-adenosylmethionine binding site [chemical binding]; other site
583355004798	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
583355004799	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
583355004800	dimerization interface [polypeptide binding]; other site
583355004801	DPS ferroxidase diiron center [ion binding]; other site
583355004802	ion pore; other site
583355004803	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
583355004804	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355004805	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355004806	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
583355004807	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
583355004808	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
583355004809	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
583355004810	ApbE family; Region: ApbE; pfam02424
583355004811	RNA methyltransferase, RsmE family; Region: TIGR00046
583355004812	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
583355004813	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
583355004814	DNA protecting protein DprA; Region: dprA; TIGR00732
583355004815	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
583355004816	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
583355004817	putative substrate binding site [chemical binding]; other site
583355004818	putative ATP binding site [chemical binding]; other site
583355004819	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
583355004820	active site
583355004821	hydrophilic channel; other site
583355004822	dimerization interface [polypeptide binding]; other site
583355004823	catalytic residues [active]
583355004824	active site lid [active]
583355004825	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
583355004826	DHH family; Region: DHH; pfam01368
583355004827	DHHA1 domain; Region: DHHA1; pfam02272
583355004828	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
583355004829	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
583355004830	Protein export membrane protein; Region: SecD_SecF; pfam02355
583355004831	Preprotein translocase subunit; Region: YajC; pfam02699
583355004832	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
583355004833	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
583355004834	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
583355004835	UbiA prenyltransferase family; Region: UbiA; pfam01040
583355004836	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
583355004837	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
583355004838	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
583355004839	WHG domain; Region: WHG; pfam13305
583355004840	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
583355004841	active site
583355004842	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
583355004843	glycine dehydrogenase; Provisional; Region: PRK05367
583355004844	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
583355004845	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
583355004846	catalytic residue [active]
583355004847	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
583355004848	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
583355004849	catalytic residue [active]
583355004850	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
583355004851	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
583355004852	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
583355004853	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
583355004854	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
583355004855	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
583355004856	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
583355004857	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
583355004858	DNA binding residues [nucleotide binding]
583355004859	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
583355004860	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
583355004861	NAD binding site [chemical binding]; other site
583355004862	homodimer interface [polypeptide binding]; other site
583355004863	active site
583355004864	substrate binding site [chemical binding]; other site
583355004865	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
583355004866	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
583355004867	dimer interface [polypeptide binding]; other site
583355004868	active site
583355004869	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
583355004870	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
583355004871	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
583355004872	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
583355004873	nucleotide binding site/active site [active]
583355004874	HIT family signature motif; other site
583355004875	catalytic residue [active]
583355004876	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
583355004877	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
583355004878	ATP cone domain; Region: ATP-cone; pfam03477
583355004879	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
583355004880	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
583355004881	glutamine binding [chemical binding]; other site
583355004882	catalytic triad [active]
583355004883	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
583355004884	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
583355004885	pyridoxal 5'-phosphate binding site [chemical binding]; other site
583355004886	catalytic residue [active]
583355004887	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
583355004888	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
583355004889	Ligand binding site; other site
583355004890	oligomer interface; other site
583355004891	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
583355004892	active site residue [active]
583355004893	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
583355004894	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
583355004895	cyclase homology domain; Region: CHD; cd07302
583355004896	nucleotidyl binding site; other site
583355004897	metal binding site [ion binding]; metal-binding site
583355004898	dimer interface [polypeptide binding]; other site
583355004899	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
583355004900	O-Antigen ligase; Region: Wzy_C; pfam04932
583355004901	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
583355004902	TPR motif; other site
583355004903	binding surface
583355004904	TPR repeat; Region: TPR_11; pfam13414
583355004905	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
583355004906	binding surface
583355004907	TPR motif; other site
583355004908	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
583355004909	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
583355004910	carboxyltransferase (CT) interaction site; other site
583355004911	biotinylation site [posttranslational modification]; other site
583355004912	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
583355004913	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
583355004914	ATP-grasp domain; Region: ATP-grasp_4; cl17255
583355004915	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
583355004916	Asp23 family; Region: Asp23; pfam03780
583355004917	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
583355004918	GSH binding site [chemical binding]; other site
583355004919	catalytic residues [active]
583355004920	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
583355004921	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
583355004922	active site
583355004923	dimer interface [polypeptide binding]; other site
583355004924	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
583355004925	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
583355004926	active site
583355004927	FMN binding site [chemical binding]; other site
583355004928	substrate binding site [chemical binding]; other site
583355004929	3Fe-4S cluster binding site [ion binding]; other site
583355004930	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
583355004931	domain interface; other site
583355004932	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
583355004933	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
583355004934	phosphodiesterase; Provisional; Region: PRK12704
583355004935	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
583355004936	Zn2+ binding site [ion binding]; other site
583355004937	Mg2+ binding site [ion binding]; other site
583355004938	hypothetical protein; Provisional; Region: PRK08609
583355004939	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
583355004940	active site
583355004941	primer binding site [nucleotide binding]; other site
583355004942	NTP  binding site [chemical binding]; other site
583355004943	metal binding triad [ion binding]; metal-binding site
583355004944	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
583355004945	active site
583355004946	O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445
583355004947	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
583355004948	acyl-activating enzyme (AAE) consensus motif; other site
583355004949	AMP binding site [chemical binding]; other site
583355004950	active site
583355004951	CoA binding site [chemical binding]; other site
583355004952	O-succinylbenzoate synthase; Provisional; Region: PRK02714
583355004953	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
583355004954	active site
583355004955	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
583355004956	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
583355004957	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
583355004958	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
583355004959	active site
583355004960	Adenylosuccinate synthetase; Region: Adenylsucc_synt; pfam00709
583355004961	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
583355004962	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
583355004963	Protein of unknown function (DUF3604); Region: DUF3604; pfam12228
583355004964	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
583355004965	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
583355004966	phosphoserine phosphatase; Provisional; Region: thrH; PRK13582
583355004967	phosphoserine phosphatase SerB; Region: serB; TIGR00338
583355004968	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
583355004969	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
583355004970	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
583355004971	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
583355004972	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
583355004973	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
583355004974	AIR carboxylase; Region: AIRC; smart01001
583355004975	hypothetical protein; Provisional; Region: PRK04194
583355004976	High-affinity nickel-transport protein; Region: NicO; cl00964
583355004977	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
583355004978	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
583355004979	Ligand Binding Site [chemical binding]; other site
583355004980	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
583355004981	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
583355004982	active site
583355004983	catalytic tetrad [active]
583355004984	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
583355004985	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
583355004986	dimer interface [polypeptide binding]; other site
583355004987	pyridoxal 5'-phosphate binding site [chemical binding]; other site
583355004988	catalytic residue [active]
583355004989	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
583355004990	rRNA binding site [nucleotide binding]; other site
583355004991	predicted 30S ribosome binding site; other site
583355004992	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
583355004993	nucleoside/Zn binding site; other site
583355004994	dimer interface [polypeptide binding]; other site
583355004995	catalytic motif [active]
583355004996	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
583355004997	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
583355004998	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
583355004999	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
583355005000	GTP-binding protein Der; Reviewed; Region: PRK00093
583355005001	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
583355005002	G1 box; other site
583355005003	GTP/Mg2+ binding site [chemical binding]; other site
583355005004	Switch I region; other site
583355005005	G2 box; other site
583355005006	Switch II region; other site
583355005007	G3 box; other site
583355005008	G4 box; other site
583355005009	G5 box; other site
583355005010	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
583355005011	G1 box; other site
583355005012	GTP/Mg2+ binding site [chemical binding]; other site
583355005013	Switch I region; other site
583355005014	G2 box; other site
583355005015	G3 box; other site
583355005016	Switch II region; other site
583355005017	G4 box; other site
583355005018	G5 box; other site
583355005019	hypothetical protein; Validated; Region: PRK07682
583355005020	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
583355005021	pyridoxal 5'-phosphate binding site [chemical binding]; other site
583355005022	homodimer interface [polypeptide binding]; other site
583355005023	catalytic residue [active]
583355005024	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
583355005025	AsnC family; Region: AsnC_trans_reg; pfam01037
583355005026	PAS fold; Region: PAS_4; pfam08448
583355005027	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355005028	dimer interface [polypeptide binding]; other site
583355005029	phosphorylation site [posttranslational modification]
583355005030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355005031	ATP binding site [chemical binding]; other site
583355005032	Mg2+ binding site [ion binding]; other site
583355005033	G-X-G motif; other site
583355005034	Response regulator receiver domain; Region: Response_reg; pfam00072
583355005035	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355005036	active site
583355005037	phosphorylation site [posttranslational modification]
583355005038	intermolecular recognition site; other site
583355005039	dimerization interface [polypeptide binding]; other site
583355005040	Response regulator receiver domain; Region: Response_reg; pfam00072
583355005041	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355005042	active site
583355005043	phosphorylation site [posttranslational modification]
583355005044	intermolecular recognition site; other site
583355005045	dimerization interface [polypeptide binding]; other site
583355005046	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
583355005047	haloalkane dehalogenase; Provisional; Region: PRK03204
583355005048	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258
583355005049	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
583355005050	active site
583355005051	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355005052	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
583355005053	NAD(P) binding site [chemical binding]; other site
583355005054	active site
583355005055	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
583355005056	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
583355005057	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
583355005058	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355005059	TIGR01777 family protein; Region: yfcH
583355005060	NAD(P) binding site [chemical binding]; other site
583355005061	active site
583355005062	DNA photolyase; Region: DNA_photolyase; pfam00875
583355005063	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
583355005064	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
583355005065	dimer interface [polypeptide binding]; other site
583355005066	FMN binding site [chemical binding]; other site
583355005067	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
583355005068	active site
583355005069	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
583355005070	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
583355005071	active site
583355005072	substrate binding site [chemical binding]; other site
583355005073	metal binding site [ion binding]; metal-binding site
583355005074	Septum formation initiator; Region: DivIC; pfam04977
583355005075	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
583355005076	AAA ATPase domain; Region: AAA_16; pfam13191
583355005077	Walker A motif; other site
583355005078	ATP binding site [chemical binding]; other site
583355005079	Walker B motif; other site
583355005080	Response regulator receiver domain; Region: Response_reg; pfam00072
583355005081	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355005082	active site
583355005083	phosphorylation site [posttranslational modification]
583355005084	intermolecular recognition site; other site
583355005085	dimerization interface [polypeptide binding]; other site
583355005086	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
583355005087	AAA domain; Region: AAA_30; pfam13604
583355005088	Family description; Region: UvrD_C_2; pfam13538
583355005089	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
583355005090	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
583355005091	FMN binding site [chemical binding]; other site
583355005092	active site
583355005093	substrate binding site [chemical binding]; other site
583355005094	catalytic residue [active]
583355005095	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
583355005096	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
583355005097	Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844
583355005098	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
583355005099	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
583355005100	Walker A/P-loop; other site
583355005101	ATP binding site [chemical binding]; other site
583355005102	Q-loop/lid; other site
583355005103	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
583355005104	ABC transporter signature motif; other site
583355005105	Walker B; other site
583355005106	D-loop; other site
583355005107	H-loop/switch region; other site
583355005108	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
583355005109	Walker A/P-loop; other site
583355005110	ATP binding site [chemical binding]; other site
583355005111	Q-loop/lid; other site
583355005112	ABC transporter signature motif; other site
583355005113	Walker B; other site
583355005114	D-loop; other site
583355005115	H-loop/switch region; other site
583355005116	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
583355005117	Walker A/P-loop; other site
583355005118	ATP binding site [chemical binding]; other site
583355005119	Q-loop/lid; other site
583355005120	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
583355005121	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
583355005122	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
583355005123	Walker A/P-loop; other site
583355005124	ATP binding site [chemical binding]; other site
583355005125	Q-loop/lid; other site
583355005126	ABC transporter signature motif; other site
583355005127	Walker B; other site
583355005128	D-loop; other site
583355005129	H-loop/switch region; other site
583355005130	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
583355005131	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
583355005132	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
583355005133	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
583355005134	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
583355005135	active site
583355005136	Zn binding site [ion binding]; other site
583355005137	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
583355005138	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
583355005139	putative active site [active]
583355005140	heme pocket [chemical binding]; other site
583355005141	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355005142	dimer interface [polypeptide binding]; other site
583355005143	phosphorylation site [posttranslational modification]
583355005144	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355005145	ATP binding site [chemical binding]; other site
583355005146	Mg2+ binding site [ion binding]; other site
583355005147	G-X-G motif; other site
583355005148	Response regulator receiver domain; Region: Response_reg; pfam00072
583355005149	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355005150	active site
583355005151	phosphorylation site [posttranslational modification]
583355005152	intermolecular recognition site; other site
583355005153	dimerization interface [polypeptide binding]; other site
583355005154	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
583355005155	chemotaxis protein; Reviewed; Region: PRK12798
583355005156	DoxX-like family; Region: DoxX_2; pfam13564
583355005157	NRDE protein; Region: NRDE; cl01315
583355005158	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
583355005159	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
583355005160	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
583355005161	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
583355005162	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
583355005163	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
583355005164	active site
583355005165	HIGH motif; other site
583355005166	dimer interface [polypeptide binding]; other site
583355005167	KMSKS motif; other site
583355005168	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
583355005169	putative active site [active]
583355005170	putative metal binding site [ion binding]; other site
583355005171	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
583355005172	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355005173	active site
583355005174	phosphorylation site [posttranslational modification]
583355005175	intermolecular recognition site; other site
583355005176	dimerization interface [polypeptide binding]; other site
583355005177	PAS domain S-box; Region: sensory_box; TIGR00229
583355005178	PAS domain; Region: PAS; smart00091
583355005179	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
583355005180	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355005181	dimer interface [polypeptide binding]; other site
583355005182	phosphorylation site [posttranslational modification]
583355005183	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355005184	ATP binding site [chemical binding]; other site
583355005185	Mg2+ binding site [ion binding]; other site
583355005186	G-X-G motif; other site
583355005187	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
583355005188	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355005189	active site
583355005190	phosphorylation site [posttranslational modification]
583355005191	intermolecular recognition site; other site
583355005192	dimerization interface [polypeptide binding]; other site
583355005193	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
583355005194	FIST N domain; Region: FIST; pfam08495
583355005195	FIST C domain; Region: FIST_C; pfam10442
583355005196	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
583355005197	ABC1 family; Region: ABC1; pfam03109
583355005198	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
583355005199	active site
583355005200	ATP binding site [chemical binding]; other site
583355005201	Uncharacterized conserved protein [Function unknown]; Region: COG3937
583355005202	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
583355005203	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
583355005204	active site
583355005205	active site
583355005206	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
583355005207	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
583355005208	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
583355005209	Cell division protein FtsA; Region: FtsA; pfam14450
583355005210	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
583355005211	nudix motif; other site
583355005212	recombination protein F; Reviewed; Region: recF; PRK00064
583355005213	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
583355005214	Walker A/P-loop; other site
583355005215	ATP binding site [chemical binding]; other site
583355005216	Q-loop/lid; other site
583355005217	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
583355005218	ABC transporter signature motif; other site
583355005219	Walker B; other site
583355005220	D-loop; other site
583355005221	H-loop/switch region; other site
583355005222	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
583355005223	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
583355005224	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
583355005225	catalytic residue [active]
583355005226	TPR repeat; Region: TPR_11; pfam13414
583355005227	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
583355005228	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
583355005229	2-enoyl thioester reductase-like; Region: ETR_like; cd05282
583355005230	NADP binding site [chemical binding]; other site
583355005231	dimer interface [polypeptide binding]; other site
583355005232	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
583355005233	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
583355005234	active site
583355005235	Zn binding site [ion binding]; other site
583355005236	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355005237	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355005238	CAAX protease self-immunity; Region: Abi; pfam02517
583355005239	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
583355005240	active site
583355005241	homodimer interface [polypeptide binding]; other site
583355005242	metal binding site [ion binding]; metal-binding site
583355005243	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
583355005244	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
583355005245	hinge; other site
583355005246	active site
583355005247	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
583355005248	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
583355005249	Walker A motif; other site
583355005250	ATP binding site [chemical binding]; other site
583355005251	Walker B motif; other site
583355005252	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
583355005253	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
583355005254	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
583355005255	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
583355005256	active site
583355005257	nucleotide binding site [chemical binding]; other site
583355005258	HIGH motif; other site
583355005259	KMSKS motif; other site
583355005260	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
583355005261	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
583355005262	active site
583355005263	HIGH motif; other site
583355005264	dimer interface [polypeptide binding]; other site
583355005265	KMSKS motif; other site
583355005266	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
583355005267	RNA binding surface [nucleotide binding]; other site
583355005268	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
583355005269	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
583355005270	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
583355005271	anti sigma factor interaction site; other site
583355005272	regulatory phosphorylation site [posttranslational modification]; other site
583355005273	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
583355005274	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
583355005275	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
583355005276	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
583355005277	rod shape-determining protein MreB; Provisional; Region: PRK13927
583355005278	MreB and similar proteins; Region: MreB_like; cd10225
583355005279	nucleotide binding site [chemical binding]; other site
583355005280	Mg binding site [ion binding]; other site
583355005281	putative protofilament interaction site [polypeptide binding]; other site
583355005282	RodZ interaction site [polypeptide binding]; other site
583355005283	rod shape-determining protein MreC; Provisional; Region: PRK13922
583355005284	rod shape-determining protein MreC; Region: MreC; pfam04085
583355005285	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
583355005286	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
583355005287	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
583355005288	short chain dehydrogenase; Provisional; Region: PRK06924
583355005289	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355005290	NAD(P) binding site [chemical binding]; other site
583355005291	active site
583355005292	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
583355005293	active site
583355005294	putative DNA-binding cleft [nucleotide binding]; other site
583355005295	dimer interface [polypeptide binding]; other site
583355005296	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
583355005297	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
583355005298	dimerization interface 3.5A [polypeptide binding]; other site
583355005299	active site
583355005300	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
583355005301	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
583355005302	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
583355005303	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
583355005304	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
583355005305	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
583355005306	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
583355005307	active site
583355005308	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
583355005309	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
583355005310	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
583355005311	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
583355005312	dimer interface [polypeptide binding]; other site
583355005313	conserved gate region; other site
583355005314	putative PBP binding loops; other site
583355005315	ABC-ATPase subunit interface; other site
583355005316	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
583355005317	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
583355005318	Walker A/P-loop; other site
583355005319	ATP binding site [chemical binding]; other site
583355005320	Q-loop/lid; other site
583355005321	ABC transporter signature motif; other site
583355005322	Walker B; other site
583355005323	D-loop; other site
583355005324	H-loop/switch region; other site
583355005325	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
583355005326	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
583355005327	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
583355005328	TrkA-N domain; Region: TrkA_N; pfam02254
583355005329	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
583355005330	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
583355005331	TrkA-N domain; Region: TrkA_N; pfam02254
583355005332	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
583355005333	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
583355005334	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
583355005335	catalytic site [active]
583355005336	subunit interface [polypeptide binding]; other site
583355005337	Protein of unknown function (DUF3485); Region: DUF3485; cl11827
583355005338	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
583355005339	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355005340	NAD(P) binding site [chemical binding]; other site
583355005341	active site
583355005342	putative glycosyl transferase; Provisional; Region: PRK10307
583355005343	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
583355005344	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
583355005345	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
583355005346	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
583355005347	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
583355005348	putative homodimer interface [polypeptide binding]; other site
583355005349	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
583355005350	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
583355005351	putative trimer interface [polypeptide binding]; other site
583355005352	putative active site [active]
583355005353	putative substrate binding site [chemical binding]; other site
583355005354	putative CoA binding site [chemical binding]; other site
583355005355	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
583355005356	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
583355005357	trimer interface [polypeptide binding]; other site
583355005358	active site
583355005359	substrate binding site [chemical binding]; other site
583355005360	CoA binding site [chemical binding]; other site
583355005361	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
583355005362	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
583355005363	O-Antigen ligase; Region: Wzy_C; pfam04932
583355005364	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914
583355005365	GDP-Fucose binding site [chemical binding]; other site
583355005366	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
583355005367	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
583355005368	putative trimer interface [polypeptide binding]; other site
583355005369	putative CoA binding site [chemical binding]; other site
583355005370	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
583355005371	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
583355005372	Mg++ binding site [ion binding]; other site
583355005373	putative catalytic motif [active]
583355005374	substrate binding site [chemical binding]; other site
583355005375	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355005376	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
583355005377	NAD(P) binding site [chemical binding]; other site
583355005378	active site
583355005379	Predicted transcriptional regulators [Transcription]; Region: COG1510
583355005380	helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418
583355005381	putative DNA binding site [nucleotide binding]; other site
583355005382	putative Zn2+ binding site [ion binding]; other site
583355005383	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
583355005384	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
583355005385	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723
583355005386	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
583355005387	active site
583355005388	FecR protein; Region: FecR; pfam04773
583355005389	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
583355005390	EamA-like transporter family; Region: EamA; pfam00892
583355005391	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
583355005392	dimerization interface [polypeptide binding]; other site
583355005393	putative DNA binding site [nucleotide binding]; other site
583355005394	putative Zn2+ binding site [ion binding]; other site
583355005395	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
583355005396	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
583355005397	FeS/SAM binding site; other site
583355005398	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
583355005399	ATP-dependent helicase HepA; Validated; Region: PRK04914
583355005400	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
583355005401	ATP binding site [chemical binding]; other site
583355005402	putative Mg++ binding site [ion binding]; other site
583355005403	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
583355005404	nucleotide binding region [chemical binding]; other site
583355005405	ATP-binding site [chemical binding]; other site
583355005406	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
583355005407	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
583355005408	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
583355005409	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
583355005410	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
583355005411	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355005412	active site
583355005413	phosphorylation site [posttranslational modification]
583355005414	intermolecular recognition site; other site
583355005415	dimerization interface [polypeptide binding]; other site
583355005416	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
583355005417	DNA binding site [nucleotide binding]
583355005418	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
583355005419	dimerization interface [polypeptide binding]; other site
583355005420	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355005421	dimer interface [polypeptide binding]; other site
583355005422	phosphorylation site [posttranslational modification]
583355005423	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355005424	ATP binding site [chemical binding]; other site
583355005425	Mg2+ binding site [ion binding]; other site
583355005426	G-X-G motif; other site
583355005427	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
583355005428	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
583355005429	ATP-grasp domain; Region: ATP-grasp; pfam02222
583355005430	anthranilate synthase component I; Provisional; Region: PRK13565
583355005431	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
583355005432	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
583355005433	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
583355005434	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
583355005435	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
583355005436	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
583355005437	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
583355005438	DNA binding residues [nucleotide binding]
583355005439	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
583355005440	Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162
583355005441	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
583355005442	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
583355005443	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
583355005444	putative active site [active]
583355005445	catalytic triad [active]
583355005446	putative dimer interface [polypeptide binding]; other site
583355005447	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901
583355005448	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
583355005449	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
583355005450	nucleotide binding region [chemical binding]; other site
583355005451	ATP-binding site [chemical binding]; other site
583355005452	cobyric acid synthase; Provisional; Region: PRK00784
583355005453	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
583355005454	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
583355005455	catalytic triad [active]
583355005456	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
583355005457	Peptidase family M48; Region: Peptidase_M48; cl12018
583355005458	tellurium resistance terB-like protein; Region: terB_like; cl11965
583355005459	metal binding site [ion binding]; metal-binding site
583355005460	Smr domain; Region: Smr; pfam01713
583355005461	RmuC family; Region: RmuC; pfam02646
583355005462	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
583355005463	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
583355005464	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
583355005465	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
583355005466	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
583355005467	metal binding site 2 [ion binding]; metal-binding site
583355005468	putative DNA binding helix; other site
583355005469	metal binding site 1 [ion binding]; metal-binding site
583355005470	dimer interface [polypeptide binding]; other site
583355005471	structural Zn2+ binding site [ion binding]; other site
583355005472	MerC mercury resistance protein; Region: MerC; pfam03203
583355005473	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
583355005474	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
583355005475	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
583355005476	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
583355005477	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
583355005478	substrate binding pocket [chemical binding]; other site
583355005479	chain length determination region; other site
583355005480	substrate-Mg2+ binding site; other site
583355005481	catalytic residues [active]
583355005482	aspartate-rich region 1; other site
583355005483	active site lid residues [active]
583355005484	aspartate-rich region 2; other site
583355005485	acyl-CoA esterase; Provisional; Region: PRK10673
583355005486	PGAP1-like protein; Region: PGAP1; pfam07819
583355005487	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
583355005488	MutS domain I; Region: MutS_I; pfam01624
583355005489	MutS domain II; Region: MutS_II; pfam05188
583355005490	MutS domain III; Region: MutS_III; pfam05192
583355005491	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
583355005492	Walker A/P-loop; other site
583355005493	ATP binding site [chemical binding]; other site
583355005494	Q-loop/lid; other site
583355005495	ABC transporter signature motif; other site
583355005496	Walker B; other site
583355005497	D-loop; other site
583355005498	H-loop/switch region; other site
583355005499	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
583355005500	nucleoside transporter; Region: 2A0110; TIGR00889
583355005501	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
583355005502	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
583355005503	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
583355005504	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898
583355005505	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
583355005506	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
583355005507	nucleotide binding region [chemical binding]; other site
583355005508	ATP-binding site [chemical binding]; other site
583355005509	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
583355005510	Peptidase family M50; Region: Peptidase_M50; pfam02163
583355005511	active site
583355005512	putative substrate binding region [chemical binding]; other site
583355005513	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
583355005514	GAF domain; Region: GAF; cl17456
583355005515	HlyD family secretion protein; Region: HlyD_3; pfam13437
583355005516	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
583355005517	HlyD family secretion protein; Region: HlyD_3; pfam13437
583355005518	Outer membrane efflux protein; Region: OEP; pfam02321
583355005519	Outer membrane efflux protein; Region: OEP; pfam02321
583355005520	DNA polymerase IV; Reviewed; Region: PRK03103
583355005521	Y-family of DNA polymerases; Region: PolY; cd00424
583355005522	active site
583355005523	DNA binding site [nucleotide binding]
583355005524	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
583355005525	Transposase IS200 like; Region: Y1_Tnp; cl00848
583355005526	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
583355005527	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
583355005528	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
583355005529	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
583355005530	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
583355005531	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
583355005532	GrpE; Region: GrpE; pfam01025
583355005533	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
583355005534	dimer interface [polypeptide binding]; other site
583355005535	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
583355005536	chaperone protein DnaJ; Provisional; Region: PRK10767
583355005537	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
583355005538	HSP70 interaction site [polypeptide binding]; other site
583355005539	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
583355005540	substrate binding site [polypeptide binding]; other site
583355005541	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
583355005542	Zn binding sites [ion binding]; other site
583355005543	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
583355005544	dimer interface [polypeptide binding]; other site
583355005545	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
583355005546	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
583355005547	active site
583355005548	substrate binding site [chemical binding]; other site
583355005549	cosubstrate binding site; other site
583355005550	catalytic site [active]
583355005551	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
583355005552	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355005553	S-adenosylmethionine binding site [chemical binding]; other site
583355005554	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
583355005555	non-specific DNA binding site [nucleotide binding]; other site
583355005556	salt bridge; other site
583355005557	sequence-specific DNA binding site [nucleotide binding]; other site
583355005558	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
583355005559	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
583355005560	This domain is found in peptide chain release factors; Region: PCRF; smart00937
583355005561	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
583355005562	RF-1 domain; Region: RF-1; pfam00472
583355005563	Domain of unknown function DUF11; Region: DUF11; pfam01345
583355005564	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
583355005565	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
583355005566	putative addiction module antidote; Region: doc_partner; TIGR02609
583355005567	Fic/DOC family; Region: Fic; cl00960
583355005568	allophanate hydrolase; Provisional; Region: PRK08186
583355005569	Amidase; Region: Amidase; cl11426
583355005570	urea carboxylase; Region: urea_carbox; TIGR02712
583355005571	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
583355005572	ATP-grasp domain; Region: ATP-grasp_4; cl17255
583355005573	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
583355005574	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
583355005575	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
583355005576	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
583355005577	carboxyltransferase (CT) interaction site; other site
583355005578	biotinylation site [posttranslational modification]; other site
583355005579	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
583355005580	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
583355005581	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
583355005582	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
583355005583	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
583355005584	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
583355005585	Creatinine amidohydrolase; Region: Creatininase; pfam02633
583355005586	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
583355005587	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
583355005588	Walker A/P-loop; other site
583355005589	ATP binding site [chemical binding]; other site
583355005590	Q-loop/lid; other site
583355005591	ABC transporter signature motif; other site
583355005592	Walker B; other site
583355005593	D-loop; other site
583355005594	H-loop/switch region; other site
583355005595	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
583355005596	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
583355005597	dimer interface [polypeptide binding]; other site
583355005598	conserved gate region; other site
583355005599	putative PBP binding loops; other site
583355005600	ABC-ATPase subunit interface; other site
583355005601	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
583355005602	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
583355005603	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
583355005604	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
583355005605	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
583355005606	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
583355005607	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
583355005608	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
583355005609	DNA polymerase III subunit beta; Provisional; Region: PRK14943
583355005610	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
583355005611	putative DNA binding surface [nucleotide binding]; other site
583355005612	dimer interface [polypeptide binding]; other site
583355005613	beta-clamp/clamp loader binding surface; other site
583355005614	beta-clamp/translesion DNA polymerase binding surface; other site
583355005615	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
583355005616	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
583355005617	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
583355005618	OsmC-like protein; Region: OsmC; pfam02566
583355005619	LytB protein; Region: LYTB; cl00507
583355005620	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
583355005621	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
583355005622	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
583355005623	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
583355005624	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
583355005625	FeS/SAM binding site; other site
583355005626	TRAM domain; Region: TRAM; cl01282
583355005627	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
583355005628	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
583355005629	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
583355005630	putative active site pocket [active]
583355005631	dimerization interface [polypeptide binding]; other site
583355005632	putative catalytic residue [active]
583355005633	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
583355005634	Pyruvate formate lyase 1; Region: PFL1; cd01678
583355005635	coenzyme A binding site [chemical binding]; other site
583355005636	active site
583355005637	catalytic residues [active]
583355005638	glycine loop; other site
583355005639	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
583355005640	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
583355005641	FeS/SAM binding site; other site
583355005642	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
583355005643	active site
583355005644	catalytic triad [active]
583355005645	oxyanion hole [active]
583355005646	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
583355005647	classical (c) SDRs; Region: SDR_c; cd05233
583355005648	NAD(P) binding site [chemical binding]; other site
583355005649	active site
583355005650	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
583355005651	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
583355005652	motif II; other site
583355005653	recombinase A; Provisional; Region: recA; PRK09354
583355005654	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
583355005655	hexamer interface [polypeptide binding]; other site
583355005656	Walker A motif; other site
583355005657	ATP binding site [chemical binding]; other site
583355005658	Walker B motif; other site
583355005659	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
583355005660	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
583355005661	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
583355005662	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
583355005663	GTP/Mg2+ binding site [chemical binding]; other site
583355005664	G5 box; other site
583355005665	trmE is a tRNA modification GTPase; Region: trmE; cd04164
583355005666	G1 box; other site
583355005667	G1 box; other site
583355005668	GTP/Mg2+ binding site [chemical binding]; other site
583355005669	Switch I region; other site
583355005670	G2 box; other site
583355005671	Switch II region; other site
583355005672	G3 box; other site
583355005673	G4 box; other site
583355005674	G5 box; other site
583355005675	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
583355005676	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
583355005677	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
583355005678	Pleckstrin homology-like domain; Region: PH-like; cl17171
583355005679	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
583355005680	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
583355005681	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355005682	active site
583355005683	phosphorylation site [posttranslational modification]
583355005684	intermolecular recognition site; other site
583355005685	dimerization interface [polypeptide binding]; other site
583355005686	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
583355005687	DNA binding site [nucleotide binding]
583355005688	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
583355005689	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355005690	dimer interface [polypeptide binding]; other site
583355005691	phosphorylation site [posttranslational modification]
583355005692	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355005693	ATP binding site [chemical binding]; other site
583355005694	Mg2+ binding site [ion binding]; other site
583355005695	G-X-G motif; other site
583355005696	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355005697	S-adenosylmethionine binding site [chemical binding]; other site
583355005698	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
583355005699	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
583355005700	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
583355005701	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
583355005702	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
583355005703	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
583355005704	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
583355005705	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
583355005706	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
583355005707	beta subunit interaction interface [polypeptide binding]; other site
583355005708	Walker A motif; other site
583355005709	ATP binding site [chemical binding]; other site
583355005710	Walker B motif; other site
583355005711	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
583355005712	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
583355005713	core domain interface [polypeptide binding]; other site
583355005714	delta subunit interface [polypeptide binding]; other site
583355005715	epsilon subunit interface [polypeptide binding]; other site
583355005716	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
583355005717	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
583355005718	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
583355005719	alpha subunit interaction interface [polypeptide binding]; other site
583355005720	Walker A motif; other site
583355005721	ATP binding site [chemical binding]; other site
583355005722	Walker B motif; other site
583355005723	inhibitor binding site; inhibition site
583355005724	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
583355005725	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
583355005726	gamma subunit interface [polypeptide binding]; other site
583355005727	epsilon subunit interface [polypeptide binding]; other site
583355005728	LBP interface [polypeptide binding]; other site
583355005729	Afadin- and alpha -actinin-Binding; Region: ADIP; pfam11559
583355005730	Type III pantothenate kinase; Region: Pan_kinase; cl17198
583355005731	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
583355005732	Biotin operon repressor [Transcription]; Region: BirA; COG1654
583355005733	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
583355005734	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
583355005735	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
583355005736	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
583355005737	dimerization interface [polypeptide binding]; other site
583355005738	active site
583355005739	Uncharacterized conserved protein [Function unknown]; Region: COG5316
583355005740	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
583355005741	carboxy-terminal protease; Provisional; Region: PRK11186
583355005742	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
583355005743	protein binding site [polypeptide binding]; other site
583355005744	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
583355005745	Catalytic dyad [active]
583355005746	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
583355005747	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
583355005748	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
583355005749	NapD protein; Region: NapD; cl01163
583355005750	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
583355005751	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
583355005752	GxxExxY protein; Region: GxxExxY; TIGR04256
583355005753	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
583355005754	TrkA-N domain; Region: TrkA_N; pfam02254
583355005755	TrkA-C domain; Region: TrkA_C; pfam02080
583355005756	TrkA-N domain; Region: TrkA_N; pfam02254
583355005757	TrkA-C domain; Region: TrkA_C; pfam02080
583355005758	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
583355005759	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
583355005760	active site
583355005761	catalytic residues [active]
583355005762	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
583355005763	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021
583355005764	dimer interface [polypeptide binding]; other site
583355005765	active site residues [active]
583355005766	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
583355005767	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
583355005768	hypothetical protein; Provisional; Region: PRK13665
583355005769	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
583355005770	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
583355005771	catalytic site [active]
583355005772	G-X2-G-X-G-K; other site
583355005773	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
583355005774	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
583355005775	motif II; other site
583355005776	TraB family; Region: TraB; pfam01963
583355005777	Predicted acetyltransferase [General function prediction only]; Region: COG2388
583355005778	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
583355005779	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
583355005780	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
583355005781	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
583355005782	substrate binding pocket [chemical binding]; other site
583355005783	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
583355005784	B12 binding site [chemical binding]; other site
583355005785	cobalt ligand [ion binding]; other site
583355005786	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
583355005787	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
583355005788	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
583355005789	DNA binding residues [nucleotide binding]
583355005790	dimerization interface [polypeptide binding]; other site
583355005791	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
583355005792	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
583355005793	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
583355005794	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
583355005795	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
583355005796	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
583355005797	putative ligand binding site [chemical binding]; other site
583355005798	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
583355005799	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
583355005800	TM-ABC transporter signature motif; other site
583355005801	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
583355005802	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
583355005803	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
583355005804	TM-ABC transporter signature motif; other site
583355005805	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
583355005806	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
583355005807	Walker A/P-loop; other site
583355005808	ATP binding site [chemical binding]; other site
583355005809	Q-loop/lid; other site
583355005810	ABC transporter signature motif; other site
583355005811	Walker B; other site
583355005812	D-loop; other site
583355005813	H-loop/switch region; other site
583355005814	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
583355005815	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
583355005816	Walker A/P-loop; other site
583355005817	ATP binding site [chemical binding]; other site
583355005818	Q-loop/lid; other site
583355005819	ABC transporter signature motif; other site
583355005820	Walker B; other site
583355005821	D-loop; other site
583355005822	H-loop/switch region; other site
583355005823	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
583355005824	alpha-gamma subunit interface [polypeptide binding]; other site
583355005825	beta-gamma subunit interface [polypeptide binding]; other site
583355005826	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
583355005827	gamma-beta subunit interface [polypeptide binding]; other site
583355005828	alpha-beta subunit interface [polypeptide binding]; other site
583355005829	urease subunit alpha; Reviewed; Region: ureC; PRK13207
583355005830	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
583355005831	subunit interactions [polypeptide binding]; other site
583355005832	active site
583355005833	flap region; other site
583355005834	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727
583355005835	dimer interface [polypeptide binding]; other site
583355005836	catalytic residues [active]
583355005837	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
583355005838	UreF; Region: UreF; pfam01730
583355005839	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
583355005840	UreD urease accessory protein; Region: UreD; pfam01774
583355005841	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
583355005842	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
583355005843	active site
583355005844	catalytic residues [active]
583355005845	metal binding site [ion binding]; metal-binding site
583355005846	SOUL heme-binding protein; Region: SOUL; pfam04832
583355005847	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
583355005848	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
583355005849	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
583355005850	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
583355005851	DsbD alpha interface [polypeptide binding]; other site
583355005852	catalytic residues [active]
583355005853	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
583355005854	putative catalytic residue [active]
583355005855	Predicted integral membrane protein [Function unknown]; Region: COG5652
583355005856	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
583355005857	GAF domain; Region: GAF; pfam01590
583355005858	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
583355005859	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
583355005860	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355005861	dimer interface [polypeptide binding]; other site
583355005862	phosphorylation site [posttranslational modification]
583355005863	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355005864	ATP binding site [chemical binding]; other site
583355005865	Mg2+ binding site [ion binding]; other site
583355005866	G-X-G motif; other site
583355005867	[Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693
583355005868	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
583355005869	metal binding triad; other site
583355005870	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
583355005871	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
583355005872	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
583355005873	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
583355005874	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
583355005875	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
583355005876	Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111
583355005877	active site
583355005878	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
583355005879	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
583355005880	E3 interaction surface; other site
583355005881	lipoyl attachment site [posttranslational modification]; other site
583355005882	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
583355005883	e3 binding domain; Region: E3_binding; pfam02817
583355005884	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
583355005885	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
583355005886	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
583355005887	alpha subunit interface [polypeptide binding]; other site
583355005888	TPP binding site [chemical binding]; other site
583355005889	heterodimer interface [polypeptide binding]; other site
583355005890	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
583355005891	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
583355005892	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
583355005893	tetramer interface [polypeptide binding]; other site
583355005894	TPP-binding site [chemical binding]; other site
583355005895	heterodimer interface [polypeptide binding]; other site
583355005896	phosphorylation loop region [posttranslational modification]
583355005897	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
583355005898	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
583355005899	active site
583355005900	HIGH motif; other site
583355005901	nucleotide binding site [chemical binding]; other site
583355005902	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
583355005903	active site
583355005904	KMSKS motif; other site
583355005905	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
583355005906	tRNA binding surface [nucleotide binding]; other site
583355005907	anticodon binding site; other site
583355005908	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
583355005909	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355005910	Sulfatase; Region: Sulfatase; pfam00884
583355005911	Surface antigen; Region: Bac_surface_Ag; pfam01103
583355005912	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
583355005913	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
583355005914	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
583355005915	intersubunit interface [polypeptide binding]; other site
583355005916	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
583355005917	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
583355005918	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
583355005919	Walker A/P-loop; other site
583355005920	ATP binding site [chemical binding]; other site
583355005921	Q-loop/lid; other site
583355005922	ABC transporter signature motif; other site
583355005923	Walker B; other site
583355005924	D-loop; other site
583355005925	H-loop/switch region; other site
583355005926	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
583355005927	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
583355005928	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
583355005929	motif II; other site
583355005930	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355005931	Sulfatase; Region: Sulfatase; pfam00884
583355005932	Oxygen tolerance; Region: BatD; pfam13584
583355005933	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
583355005934	metal ion-dependent adhesion site (MIDAS); other site
583355005935	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
583355005936	Protein of unknown function DUF58; Region: DUF58; pfam01882
583355005937	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
583355005938	MoxR-like ATPases [General function prediction only]; Region: COG0714
583355005939	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
583355005940	Walker A motif; other site
583355005941	ATP binding site [chemical binding]; other site
583355005942	Walker B motif; other site
583355005943	arginine finger; other site
583355005944	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355005945	Sulfatase; Region: Sulfatase; pfam00884
583355005946	Methyltransferase domain; Region: Methyltransf_31; pfam13847
583355005947	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355005948	S-adenosylmethionine binding site [chemical binding]; other site
583355005949	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
583355005950	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
583355005951	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
583355005952	active site
583355005953	hypothetical protein; Reviewed; Region: PRK12497
583355005954	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
583355005955	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
583355005956	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
583355005957	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
583355005958	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
583355005959	catalytic triad [active]
583355005960	Methyltransferase domain; Region: Methyltransf_23; pfam13489
583355005961	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355005962	S-adenosylmethionine binding site [chemical binding]; other site
583355005963	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
583355005964	Ligand binding site; other site
583355005965	Putative Catalytic site; other site
583355005966	DXD motif; other site
583355005967	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
583355005968	tetramer interface [polypeptide binding]; other site
583355005969	TPP-binding site [chemical binding]; other site
583355005970	heterodimer interface [polypeptide binding]; other site
583355005971	phosphorylation loop region [posttranslational modification]
583355005972	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
583355005973	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
583355005974	alpha subunit interface [polypeptide binding]; other site
583355005975	TPP binding site [chemical binding]; other site
583355005976	heterodimer interface [polypeptide binding]; other site
583355005977	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
583355005978	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
583355005979	E3 interaction surface; other site
583355005980	lipoyl attachment site [posttranslational modification]; other site
583355005981	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
583355005982	Sensors of blue-light using FAD; Region: BLUF; pfam04940
583355005983	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
583355005984	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
583355005985	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
583355005986	domain interfaces; other site
583355005987	active site
583355005988	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
583355005989	putative GTP cyclohydrolase; Provisional; Region: PRK13674
583355005990	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
583355005991	nudix motif; other site
583355005992	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
583355005993	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355005994	active site
583355005995	phosphorylation site [posttranslational modification]
583355005996	intermolecular recognition site; other site
583355005997	dimerization interface [polypeptide binding]; other site
583355005998	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
583355005999	Walker A motif; other site
583355006000	ATP binding site [chemical binding]; other site
583355006001	Walker B motif; other site
583355006002	arginine finger; other site
583355006003	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
583355006004	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
583355006005	Methylamine utilisation protein MauE; Region: MauE; pfam07291
583355006006	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
583355006007	active site residue [active]
583355006008	Protein of unknown function, DUF481; Region: DUF481; cl01213
583355006009	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
583355006010	putative active site [active]
583355006011	short chain dehydrogenase; Provisional; Region: PRK06197
583355006012	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
583355006013	putative NAD(P) binding site [chemical binding]; other site
583355006014	active site
583355006015	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
583355006016	catalytic residues [active]
583355006017	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
583355006018	Interdomain contacts; other site
583355006019	Cytokine receptor motif; other site
583355006020	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
583355006021	glycerol kinase; Provisional; Region: glpK; PRK00047
583355006022	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
583355006023	N- and C-terminal domain interface [polypeptide binding]; other site
583355006024	active site
583355006025	MgATP binding site [chemical binding]; other site
583355006026	catalytic site [active]
583355006027	metal binding site [ion binding]; metal-binding site
583355006028	glycerol binding site [chemical binding]; other site
583355006029	homotetramer interface [polypeptide binding]; other site
583355006030	homodimer interface [polypeptide binding]; other site
583355006031	FBP binding site [chemical binding]; other site
583355006032	protein IIAGlc interface [polypeptide binding]; other site
583355006033	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
583355006034	Mechanosensitive ion channel; Region: MS_channel; pfam00924
583355006035	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
583355006036	active site
583355006037	HIGH motif; other site
583355006038	nucleotide binding site [chemical binding]; other site
583355006039	active site
583355006040	KMSKS motif; other site
583355006041	helicase 45; Provisional; Region: PTZ00424
583355006042	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
583355006043	ATP binding site [chemical binding]; other site
583355006044	Mg++ binding site [ion binding]; other site
583355006045	motif III; other site
583355006046	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
583355006047	nucleotide binding region [chemical binding]; other site
583355006048	ATP-binding site [chemical binding]; other site
583355006049	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
583355006050	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
583355006051	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
583355006052	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
583355006053	active site clefts [active]
583355006054	zinc binding site [ion binding]; other site
583355006055	dimer interface [polypeptide binding]; other site
583355006056	aspartate aminotransferase; Provisional; Region: PRK06290
583355006057	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
583355006058	pyridoxal 5'-phosphate binding site [chemical binding]; other site
583355006059	homodimer interface [polypeptide binding]; other site
583355006060	catalytic residue [active]
583355006061	pantoate--beta-alanine ligase; Region: panC; TIGR00018
583355006062	Pantoate-beta-alanine ligase; Region: PanC; cd00560
583355006063	active site
583355006064	ATP-binding site [chemical binding]; other site
583355006065	pantoate-binding site; other site
583355006066	HXXH motif; other site
583355006067	L-aspartate oxidase; Provisional; Region: PRK09077
583355006068	L-aspartate oxidase; Provisional; Region: PRK06175
583355006069	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
583355006070	2-dehydropantoate 2-reductase; Provisional; Region: PRK06249
583355006071	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
583355006072	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
583355006073	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
583355006074	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
583355006075	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
583355006076	minor groove reading motif; other site
583355006077	helix-hairpin-helix signature motif; other site
583355006078	substrate binding pocket [chemical binding]; other site
583355006079	active site
583355006080	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
583355006081	Clp amino terminal domain; Region: Clp_N; pfam02861
583355006082	Clp amino terminal domain; Region: Clp_N; pfam02861
583355006083	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
583355006084	Walker A motif; other site
583355006085	ATP binding site [chemical binding]; other site
583355006086	Walker B motif; other site
583355006087	arginine finger; other site
583355006088	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
583355006089	Walker A motif; other site
583355006090	ATP binding site [chemical binding]; other site
583355006091	Walker B motif; other site
583355006092	arginine finger; other site
583355006093	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
583355006094	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
583355006095	oligomerization interface [polypeptide binding]; other site
583355006096	active site
583355006097	metal binding site [ion binding]; metal-binding site
583355006098	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
583355006099	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
583355006100	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
583355006101	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
583355006102	glycyl-tRNA synthetase; Provisional; Region: PRK04173
583355006103	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
583355006104	motif 1; other site
583355006105	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
583355006106	active site
583355006107	motif 2; other site
583355006108	motif 3; other site
583355006109	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
583355006110	anticodon binding site; other site
583355006111	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
583355006112	putative acyl-acceptor binding pocket; other site
583355006113	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
583355006114	PhoU domain; Region: PhoU; pfam01895
583355006115	PhoU domain; Region: PhoU; pfam01895
583355006116	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
583355006117	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
583355006118	Walker A/P-loop; other site
583355006119	ATP binding site [chemical binding]; other site
583355006120	Q-loop/lid; other site
583355006121	ABC transporter signature motif; other site
583355006122	Walker B; other site
583355006123	D-loop; other site
583355006124	H-loop/switch region; other site
583355006125	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
583355006126	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
583355006127	dimer interface [polypeptide binding]; other site
583355006128	conserved gate region; other site
583355006129	putative PBP binding loops; other site
583355006130	ABC-ATPase subunit interface; other site
583355006131	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
583355006132	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
583355006133	dimer interface [polypeptide binding]; other site
583355006134	conserved gate region; other site
583355006135	putative PBP binding loops; other site
583355006136	ABC-ATPase subunit interface; other site
583355006137	PBP superfamily domain; Region: PBP_like_2; cl17296
583355006138	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
583355006139	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
583355006140	PBP superfamily domain; Region: PBP_like_2; cl17296
583355006141	Cna protein B-type domain; Region: Cna_B_2; pfam13715
583355006142	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
583355006143	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
583355006144	TPR repeat; Region: TPR_11; pfam13414
583355006145	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
583355006146	TPR motif; other site
583355006147	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
583355006148	binding surface
583355006149	TPR motif; other site
583355006150	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
583355006151	binding surface
583355006152	TPR motif; other site
583355006153	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
583355006154	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
583355006155	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
583355006156	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
583355006157	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
583355006158	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
583355006159	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
583355006160	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
583355006161	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
583355006162	active site
583355006163	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
583355006164	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
583355006165	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
583355006166	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
583355006167	phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878
583355006168	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
583355006169	dimerization interface [polypeptide binding]; other site
583355006170	ATP binding site [chemical binding]; other site
583355006171	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
583355006172	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
583355006173	putative acyl-acceptor binding pocket; other site
583355006174	cytidylate kinase; Provisional; Region: cmk; PRK00023
583355006175	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
583355006176	CMP-binding site; other site
583355006177	The sites determining sugar specificity; other site
583355006178	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
583355006179	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
583355006180	hinge; other site
583355006181	active site
583355006182	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
583355006183	prephenate dehydrogenase; Validated; Region: PRK08507
583355006184	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
583355006185	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
583355006186	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
583355006187	putative active site [active]
583355006188	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
583355006189	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
583355006190	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
583355006191	Methyltransferase domain; Region: Methyltransf_23; pfam13489
583355006192	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355006193	S-adenosylmethionine binding site [chemical binding]; other site
583355006194	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
583355006195	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
583355006196	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
583355006197	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355006198	NAD(P) binding site [chemical binding]; other site
583355006199	active site
583355006200	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
583355006201	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
583355006202	Ligand binding site; other site
583355006203	Putative Catalytic site; other site
583355006204	DXD motif; other site
583355006205	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
583355006206	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
583355006207	Methyltransferase domain; Region: Methyltransf_23; pfam13489
583355006208	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355006209	S-adenosylmethionine binding site [chemical binding]; other site
583355006210	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
583355006211	Ligand binding site; other site
583355006212	Putative Catalytic site; other site
583355006213	DXD motif; other site
583355006214	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
583355006215	GIY-YIG motif/motif A; other site
583355006216	active site
583355006217	catalytic site [active]
583355006218	putative DNA binding site [nucleotide binding]; other site
583355006219	metal binding site [ion binding]; metal-binding site
583355006220	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
583355006221	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
583355006222	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
583355006223	competence damage-inducible protein A; Provisional; Region: PRK00549
583355006224	putative MPT binding site; other site
583355006225	Competence-damaged protein; Region: CinA; pfam02464
583355006226	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
583355006227	Cupin domain; Region: Cupin_2; pfam07883
583355006228	adenylosuccinate lyase; Region: purB; TIGR00928
583355006229	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
583355006230	tetramer interface [polypeptide binding]; other site
583355006231	6-phosphofructokinase; Provisional; Region: PRK14072
583355006232	active site
583355006233	ADP/pyrophosphate binding site [chemical binding]; other site
583355006234	allosteric effector site; other site
583355006235	dimerization interface [polypeptide binding]; other site
583355006236	fructose-1,6-bisphosphate binding site; other site
583355006237	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
583355006238	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
583355006239	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
583355006240	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
583355006241	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
583355006242	active site residue [active]
583355006243	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
583355006244	CPxP  motif; other site
583355006245	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
583355006246	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
583355006247	dimerization interface [polypeptide binding]; other site
583355006248	putative DNA binding site [nucleotide binding]; other site
583355006249	putative Zn2+ binding site [ion binding]; other site
583355006250	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
583355006251	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
583355006252	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
583355006253	active site
583355006254	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
583355006255	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
583355006256	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
583355006257	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
583355006258	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
583355006259	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
583355006260	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
583355006261	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
583355006262	Walker A/P-loop; other site
583355006263	ATP binding site [chemical binding]; other site
583355006264	Q-loop/lid; other site
583355006265	ABC transporter signature motif; other site
583355006266	Walker B; other site
583355006267	D-loop; other site
583355006268	H-loop/switch region; other site
583355006269	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
583355006270	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
583355006271	catalytic site [active]
583355006272	putative active site [active]
583355006273	putative substrate binding site [chemical binding]; other site
583355006274	HRDC domain; Region: HRDC; pfam00570
583355006275	Predicted methyltransferases [General function prediction only]; Region: COG0313
583355006276	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
583355006277	putative SAM binding site [chemical binding]; other site
583355006278	putative homodimer interface [polypeptide binding]; other site
583355006279	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
583355006280	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
583355006281	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
583355006282	active site
583355006283	dimer interface [polypeptide binding]; other site
583355006284	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
583355006285	dimer interface [polypeptide binding]; other site
583355006286	active site
583355006287	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
583355006288	6-phosphogluconate dehydratase; Region: edd; TIGR01196
583355006289	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
583355006290	Chorismate mutase type II; Region: CM_2; pfam01817
583355006291	Chorismate mutase type II; Region: CM_2; smart00830
583355006292	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
583355006293	Prephenate dehydratase; Region: PDT; pfam00800
583355006294	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
583355006295	putative L-Phe binding site [chemical binding]; other site
583355006296	Protein of unknown function (DUF3379); Region: DUF3379; pfam11859
583355006297	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
583355006298	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
583355006299	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
583355006300	DNA binding residues [nucleotide binding]
583355006301	Spondin_N; Region: Spond_N; pfam06468
583355006302	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
583355006303	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
583355006304	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
583355006305	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
583355006306	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
583355006307	ATP binding site [chemical binding]; other site
583355006308	putative Mg++ binding site [ion binding]; other site
583355006309	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
583355006310	nucleotide binding region [chemical binding]; other site
583355006311	ATP-binding site [chemical binding]; other site
583355006312	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
583355006313	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
583355006314	Dehydroquinase class II; Region: DHquinase_II; pfam01220
583355006315	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
583355006316	trimer interface [polypeptide binding]; other site
583355006317	active site
583355006318	dimer interface [polypeptide binding]; other site
583355006319	dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486
583355006320	Uncharacterized conserved protein [Function unknown]; Region: COG0327
583355006321	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
583355006322	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
583355006323	putative ATP binding site [chemical binding]; other site
583355006324	putative substrate interface [chemical binding]; other site
583355006325	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
583355006326	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
583355006327	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355006328	dimer interface [polypeptide binding]; other site
583355006329	phosphorylation site [posttranslational modification]
583355006330	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355006331	ATP binding site [chemical binding]; other site
583355006332	Mg2+ binding site [ion binding]; other site
583355006333	G-X-G motif; other site
583355006334	Response regulator receiver domain; Region: Response_reg; pfam00072
583355006335	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355006336	active site
583355006337	phosphorylation site [posttranslational modification]
583355006338	intermolecular recognition site; other site
583355006339	dimerization interface [polypeptide binding]; other site
583355006340	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
583355006341	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
583355006342	FeS/SAM binding site; other site
583355006343	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
583355006344	ATP cone domain; Region: ATP-cone; pfam03477
583355006345	Class III ribonucleotide reductase; Region: RNR_III; cd01675
583355006346	effector binding site; other site
583355006347	active site
583355006348	Zn binding site [ion binding]; other site
583355006349	glycine loop; other site
583355006350	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
583355006351	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
583355006352	putative active site [active]
583355006353	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
583355006354	O-Antigen ligase; Region: Wzy_C; pfam04932
583355006355	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
583355006356	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
583355006357	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
583355006358	Walker A/P-loop; other site
583355006359	ATP binding site [chemical binding]; other site
583355006360	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
583355006361	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
583355006362	ABC transporter signature motif; other site
583355006363	Walker B; other site
583355006364	D-loop; other site
583355006365	H-loop/switch region; other site
583355006366	GMP synthase; Reviewed; Region: guaA; PRK00074
583355006367	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
583355006368	AMP/PPi binding site [chemical binding]; other site
583355006369	candidate oxyanion hole; other site
583355006370	catalytic triad [active]
583355006371	potential glutamine specificity residues [chemical binding]; other site
583355006372	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
583355006373	ATP Binding subdomain [chemical binding]; other site
583355006374	Ligand Binding sites [chemical binding]; other site
583355006375	Dimerization subdomain; other site
583355006376	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
583355006377	histidinol dehydrogenase; Region: hisD; TIGR00069
583355006378	NAD binding site [chemical binding]; other site
583355006379	dimerization interface [polypeptide binding]; other site
583355006380	product binding site; other site
583355006381	substrate binding site [chemical binding]; other site
583355006382	zinc binding site [ion binding]; other site
583355006383	catalytic residues [active]
583355006384	Protein of unknown function, DUF481; Region: DUF481; pfam04338
583355006385	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
583355006386	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
583355006387	pyridoxal 5'-phosphate binding site [chemical binding]; other site
583355006388	homodimer interface [polypeptide binding]; other site
583355006389	catalytic residue [active]
583355006390	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
583355006391	putative active site pocket [active]
583355006392	4-fold oligomerization interface [polypeptide binding]; other site
583355006393	metal binding residues [ion binding]; metal-binding site
583355006394	3-fold/trimer interface [polypeptide binding]; other site
583355006395	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
583355006396	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
583355006397	putative active site [active]
583355006398	oxyanion strand; other site
583355006399	catalytic triad [active]
583355006400	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
583355006401	dimer interface [polypeptide binding]; other site
583355006402	Citrate synthase; Region: Citrate_synt; pfam00285
583355006403	active site
583355006404	citrylCoA binding site [chemical binding]; other site
583355006405	NADH binding [chemical binding]; other site
583355006406	cationic pore residues; other site
583355006407	oxalacetate/citrate binding site [chemical binding]; other site
583355006408	coenzyme A binding site [chemical binding]; other site
583355006409	catalytic triad [active]
583355006410	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
583355006411	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
583355006412	putative active site [active]
583355006413	heme pocket [chemical binding]; other site
583355006414	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355006415	dimer interface [polypeptide binding]; other site
583355006416	phosphorylation site [posttranslational modification]
583355006417	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355006418	ATP binding site [chemical binding]; other site
583355006419	Mg2+ binding site [ion binding]; other site
583355006420	G-X-G motif; other site
583355006421	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
583355006422	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
583355006423	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
583355006424	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12880
583355006425	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
583355006426	dimer interface [polypeptide binding]; other site
583355006427	active site
583355006428	CoA binding pocket [chemical binding]; other site
583355006429	Phosphopantetheine attachment site; Region: PP-binding; cl09936
583355006430	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355006431	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355006432	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
583355006433	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
583355006434	putative trimer interface [polypeptide binding]; other site
583355006435	putative CoA binding site [chemical binding]; other site
583355006436	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
583355006437	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
583355006438	acyl-activating enzyme (AAE) consensus motif; other site
583355006439	active site
583355006440	AMP binding site [chemical binding]; other site
583355006441	CoA binding site [chemical binding]; other site
583355006442	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
583355006443	classical (c) SDRs; Region: SDR_c; cd05233
583355006444	NAD(P) binding site [chemical binding]; other site
583355006445	active site
583355006446	Bacterial sugar transferase; Region: Bac_transf; pfam02397
583355006447	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
583355006448	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
583355006449	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
583355006450	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
583355006451	HlyD family secretion protein; Region: HlyD_3; pfam13437
583355006452	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
583355006453	Methyltransferase domain; Region: Methyltransf_31; pfam13847
583355006454	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355006455	S-adenosylmethionine binding site [chemical binding]; other site
583355006456	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
583355006457	putative active site [active]
583355006458	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
583355006459	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
583355006460	Predicted membrane protein [Function unknown]; Region: COG2246
583355006461	GtrA-like protein; Region: GtrA; pfam04138
583355006462	integral membrane protein; Region: integ_memb_HG; TIGR03954
583355006463	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
583355006464	active site
583355006465	Predicted permeases [General function prediction only]; Region: COG0795
583355006466	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
583355006467	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
583355006468	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
583355006469	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
583355006470	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
583355006471	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
583355006472	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
583355006473	pyridoxal 5'-phosphate binding site [chemical binding]; other site
583355006474	catalytic residue [active]
583355006475	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
583355006476	dihydropteroate synthase; Region: DHPS; TIGR01496
583355006477	substrate binding pocket [chemical binding]; other site
583355006478	dimer interface [polypeptide binding]; other site
583355006479	inhibitor binding site; inhibition site
583355006480	Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539
583355006481	active site
583355006482	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
583355006483	catalytic center binding site [active]
583355006484	ATP binding site [chemical binding]; other site
583355006485	Rdx family; Region: Rdx; cl01407
583355006486	SMUG: single-strand-selective monofunctional uracil-DNA glycosylase; Region: UDG_F3_SMUG; cd10029
583355006487	active site
583355006488	substrate specificity residue; other site
583355006489	DNA binding site [nucleotide binding]
583355006490	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
583355006491	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
583355006492	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355006493	dimer interface [polypeptide binding]; other site
583355006494	phosphorylation site [posttranslational modification]
583355006495	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355006496	ATP binding site [chemical binding]; other site
583355006497	Mg2+ binding site [ion binding]; other site
583355006498	G-X-G motif; other site
583355006499	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
583355006500	acyl transferase; Provisional; Region: luxD; PRK13604
583355006501	Methyltransferase domain; Region: Methyltransf_31; pfam13847
583355006502	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355006503	S-adenosylmethionine binding site [chemical binding]; other site
583355006504	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
583355006505	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355006506	dimer interface [polypeptide binding]; other site
583355006507	phosphorylation site [posttranslational modification]
583355006508	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355006509	ATP binding site [chemical binding]; other site
583355006510	Mg2+ binding site [ion binding]; other site
583355006511	G-X-G motif; other site
583355006512	Response regulator receiver domain; Region: Response_reg; pfam00072
583355006513	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355006514	active site
583355006515	phosphorylation site [posttranslational modification]
583355006516	intermolecular recognition site; other site
583355006517	dimerization interface [polypeptide binding]; other site
583355006518	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355006519	dimer interface [polypeptide binding]; other site
583355006520	phosphorylation site [posttranslational modification]
583355006521	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355006522	ATP binding site [chemical binding]; other site
583355006523	Mg2+ binding site [ion binding]; other site
583355006524	G-X-G motif; other site
583355006525	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
583355006526	tetramerization interface [polypeptide binding]; other site
583355006527	active site
583355006528	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
583355006529	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
583355006530	dimer interface [polypeptide binding]; other site
583355006531	active site
583355006532	glycine-pyridoxal phosphate binding site [chemical binding]; other site
583355006533	folate binding site [chemical binding]; other site
583355006534	Survival protein SurE; Region: SurE; pfam01975
583355006535	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
583355006536	active site
583355006537	transaldolase-like protein; Provisional; Region: PTZ00411
583355006538	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
583355006539	active site
583355006540	dimer interface [polypeptide binding]; other site
583355006541	catalytic residue [active]
583355006542	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
583355006543	argininosuccinate synthase; Provisional; Region: PRK13820
583355006544	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
583355006545	ANP binding site [chemical binding]; other site
583355006546	Substrate Binding Site II [chemical binding]; other site
583355006547	Substrate Binding Site I [chemical binding]; other site
583355006548	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
583355006549	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
583355006550	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
583355006551	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
583355006552	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
583355006553	tRNA; other site
583355006554	putative tRNA binding site [nucleotide binding]; other site
583355006555	putative NADP binding site [chemical binding]; other site
583355006556	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
583355006557	ferrochelatase; Reviewed; Region: hemH; PRK00035
583355006558	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
583355006559	C-terminal domain interface [polypeptide binding]; other site
583355006560	active site
583355006561	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
583355006562	active site
583355006563	N-terminal domain interface [polypeptide binding]; other site
583355006564	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
583355006565	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
583355006566	NADP-binding site; other site
583355006567	homotetramer interface [polypeptide binding]; other site
583355006568	substrate binding site [chemical binding]; other site
583355006569	homodimer interface [polypeptide binding]; other site
583355006570	active site
583355006571	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
583355006572	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
583355006573	NADP binding site [chemical binding]; other site
583355006574	active site
583355006575	putative substrate binding site [chemical binding]; other site
583355006576	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
583355006577	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
583355006578	Walker A/P-loop; other site
583355006579	ATP binding site [chemical binding]; other site
583355006580	Q-loop/lid; other site
583355006581	ABC transporter signature motif; other site
583355006582	Walker B; other site
583355006583	D-loop; other site
583355006584	H-loop/switch region; other site
583355006585	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
583355006586	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
583355006587	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
583355006588	exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178
583355006589	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
583355006590	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
583355006591	active site
583355006592	PHP Thumb interface [polypeptide binding]; other site
583355006593	metal binding site [ion binding]; metal-binding site
583355006594	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
583355006595	generic binding surface II; other site
583355006596	generic binding surface I; other site
583355006597	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
583355006598	classical (c) SDRs; Region: SDR_c; cd05233
583355006599	NAD(P) binding site [chemical binding]; other site
583355006600	active site
583355006601	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
583355006602	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
583355006603	catalytic triad [active]
583355006604	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
583355006605	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
583355006606	intersubunit interface [polypeptide binding]; other site
583355006607	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
583355006608	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
583355006609	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
583355006610	NADP binding site [chemical binding]; other site
583355006611	active site
583355006612	putative substrate binding site [chemical binding]; other site
583355006613	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
583355006614	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
583355006615	pyridoxal 5'-phosphate binding site [chemical binding]; other site
583355006616	homodimer interface [polypeptide binding]; other site
583355006617	catalytic residue [active]
583355006618	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
583355006619	Domain of unknown function DUF21; Region: DUF21; pfam01595
583355006620	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
583355006621	Transporter associated domain; Region: CorC_HlyC; smart01091
583355006622	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
583355006623	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
583355006624	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
583355006625	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
583355006626	SLBB domain; Region: SLBB; pfam10531
583355006627	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
583355006628	Chain length determinant protein; Region: Wzz; cl15801
583355006629	Chain length determinant protein; Region: Wzz; cl15801
583355006630	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
583355006631	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
583355006632	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
583355006633	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
583355006634	Ribosomal protein S18; Region: Ribosomal_S18; pfam01084
583355006635	DEAD-like helicases superfamily; Region: DEXDc; smart00487
583355006636	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
583355006637	ATP binding site [chemical binding]; other site
583355006638	putative Mg++ binding site [ion binding]; other site
583355006639	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
583355006640	nucleotide binding region [chemical binding]; other site
583355006641	ATP-binding site [chemical binding]; other site
583355006642	RQC domain; Region: RQC; pfam09382
583355006643	HRDC domain; Region: HRDC; pfam00570
583355006644	NAD-dependent deacetylase; Provisional; Region: PRK00481
583355006645	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
583355006646	NAD+ binding site [chemical binding]; other site
583355006647	substrate binding site [chemical binding]; other site
583355006648	Zn binding site [ion binding]; other site
583355006649	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
583355006650	TPR motif; other site
583355006651	binding surface
583355006652	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
583355006653	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
583355006654	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
583355006655	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
583355006656	Gram-negative bacterial tonB protein; Region: TonB; cl10048
583355006657	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
583355006658	catalytic motif [active]
583355006659	Zn binding site [ion binding]; other site
583355006660	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
583355006661	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
583355006662	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
583355006663	Competence protein; Region: Competence; pfam03772
583355006664	recombination factor protein RarA; Reviewed; Region: PRK13342
583355006665	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
583355006666	Walker A motif; other site
583355006667	ATP binding site [chemical binding]; other site
583355006668	Walker B motif; other site
583355006669	arginine finger; other site
583355006670	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
583355006671	Membrane protein of unknown function; Region: DUF360; pfam04020
583355006672	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
583355006673	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
583355006674	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
583355006675	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
583355006676	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
583355006677	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
583355006678	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
583355006679	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
583355006680	Coenzyme A binding pocket [chemical binding]; other site
583355006681	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
583355006682	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
583355006683	glutaminase active site [active]
583355006684	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
583355006685	dimer interface [polypeptide binding]; other site
583355006686	active site
583355006687	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
583355006688	dimer interface [polypeptide binding]; other site
583355006689	active site
583355006690	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
583355006691	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
583355006692	ligand binding site; other site
583355006693	oligomer interface; other site
583355006694	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
583355006695	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
583355006696	dimer interface [polypeptide binding]; other site
583355006697	N-terminal domain interface [polypeptide binding]; other site
583355006698	sulfate 1 binding site; other site
583355006699	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
583355006700	Ligand Binding Site [chemical binding]; other site
583355006701	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
583355006702	Ligand Binding Site [chemical binding]; other site
583355006703	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
583355006704	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
583355006705	N-terminal plug; other site
583355006706	ligand-binding site [chemical binding]; other site
583355006707	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
583355006708	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
583355006709	N-terminal plug; other site
583355006710	ligand-binding site [chemical binding]; other site
583355006711	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
583355006712	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
583355006713	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
583355006714	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
583355006715	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
583355006716	ParB-like nuclease domain; Region: ParB; smart00470
583355006717	EVE domain; Region: EVE; cl00728
583355006718	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
583355006719	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
583355006720	ligand binding site [chemical binding]; other site
583355006721	flexible hinge region; other site
583355006722	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
583355006723	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355006724	dimer interface [polypeptide binding]; other site
583355006725	phosphorylation site [posttranslational modification]
583355006726	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355006727	ATP binding site [chemical binding]; other site
583355006728	Mg2+ binding site [ion binding]; other site
583355006729	G-X-G motif; other site
583355006730	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
583355006731	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
583355006732	dimer interface [polypeptide binding]; other site
583355006733	active site
583355006734	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
583355006735	catalytic residues [active]
583355006736	substrate binding site [chemical binding]; other site
583355006737	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
583355006738	Ribonuclease P; Region: Ribonuclease_P; pfam00825
583355006739	Haemolytic domain; Region: Haemolytic; pfam01809
583355006740	membrane protein insertase; Provisional; Region: PRK01318
583355006741	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
583355006742	hypothetical protein; Validated; Region: PRK00110
583355006743	peptide synthase; Provisional; Region: PRK09274
583355006744	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910
583355006745	acyl-activating enzyme (AAE) consensus motif; other site
583355006746	putative AMP binding site [chemical binding]; other site
583355006747	putative active site [active]
583355006748	putative CoA binding site [chemical binding]; other site
583355006749	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355006750	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
583355006751	NAD(P) binding site [chemical binding]; other site
583355006752	active site
583355006753	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
583355006754	dimer interface [polypeptide binding]; other site
583355006755	phosphorylation site [posttranslational modification]
583355006756	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355006757	active site
583355006758	phosphorylation site [posttranslational modification]
583355006759	intermolecular recognition site; other site
583355006760	dimerization interface [polypeptide binding]; other site
583355006761	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
583355006762	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
583355006763	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
583355006764	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
583355006765	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
583355006766	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
583355006767	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
583355006768	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
583355006769	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
583355006770	putative dimer interface [polypeptide binding]; other site
583355006771	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
583355006772	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
583355006773	putative dimer interface [polypeptide binding]; other site
583355006774	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
583355006775	rRNA interaction site [nucleotide binding]; other site
583355006776	S8 interaction site; other site
583355006777	putative laminin-1 binding site; other site
583355006778	elongation factor Ts; Reviewed; Region: tsf; PRK12332
583355006779	UBA/TS-N domain; Region: UBA; pfam00627
583355006780	Elongation factor TS; Region: EF_TS; pfam00889
583355006781	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
583355006782	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
583355006783	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
583355006784	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
583355006785	Substrate binding site; other site
583355006786	Cupin domain; Region: Cupin_2; cl17218
583355006787	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
583355006788	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
583355006789	Permease; Region: Permease; pfam02405
583355006790	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
583355006791	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
583355006792	Walker A/P-loop; other site
583355006793	ATP binding site [chemical binding]; other site
583355006794	Q-loop/lid; other site
583355006795	ABC transporter signature motif; other site
583355006796	Walker B; other site
583355006797	D-loop; other site
583355006798	H-loop/switch region; other site
583355006799	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
583355006800	mce related protein; Region: MCE; pfam02470
583355006801	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
583355006802	VacJ like lipoprotein; Region: VacJ; cl01073
583355006803	Protein of unknown function (DUF983); Region: DUF983; cl02211
583355006804	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
583355006805	active site
583355006806	Fe-S metabolism associated domain; Region: SufE; cl00951
583355006807	enolase; Provisional; Region: eno; PRK00077
583355006808	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
583355006809	dimer interface [polypeptide binding]; other site
583355006810	metal binding site [ion binding]; metal-binding site
583355006811	substrate binding pocket [chemical binding]; other site
583355006812	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
583355006813	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
583355006814	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
583355006815	putative active site [active]
583355006816	putative substrate binding site [chemical binding]; other site
583355006817	putative cosubstrate binding site; other site
583355006818	catalytic site [active]
583355006819	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
583355006820	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
583355006821	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
583355006822	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
583355006823	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
583355006824	ATP-grasp domain; Region: ATP-grasp_4; cl17255
583355006825	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
583355006826	IMP binding site; other site
583355006827	dimer interface [polypeptide binding]; other site
583355006828	interdomain contacts; other site
583355006829	partial ornithine binding site; other site
583355006830	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
583355006831	binding surface
583355006832	TPR motif; other site
583355006833	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
583355006834	META domain; Region: META; pfam03724
583355006835	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
583355006836	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
583355006837	Chromate transporter; Region: Chromate_transp; pfam02417
583355006838	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
583355006839	metal ion-dependent adhesion site (MIDAS); other site
583355006840	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14460
583355006841	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
583355006842	FeS/SAM binding site; other site
583355006843	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
583355006844	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
583355006845	pyruvate phosphate dikinase; Provisional; Region: PRK09279
583355006846	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
583355006847	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
583355006848	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
583355006849	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
583355006850	aspartate aminotransferase; Provisional; Region: PRK05764
583355006851	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
583355006852	pyridoxal 5'-phosphate binding site [chemical binding]; other site
583355006853	homodimer interface [polypeptide binding]; other site
583355006854	catalytic residue [active]
583355006855	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
583355006856	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
583355006857	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
583355006858	putative active site [active]
583355006859	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
583355006860	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
583355006861	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
583355006862	FeS/SAM binding site; other site
583355006863	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
583355006864	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
583355006865	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
583355006866	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
583355006867	catalytic residues [active]
583355006868	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
583355006869	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
583355006870	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
583355006871	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
583355006872	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
583355006873	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
583355006874	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
583355006875	Walker A/P-loop; other site
583355006876	ATP binding site [chemical binding]; other site
583355006877	Q-loop/lid; other site
583355006878	ABC transporter signature motif; other site
583355006879	Walker B; other site
583355006880	D-loop; other site
583355006881	H-loop/switch region; other site
583355006882	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
583355006883	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
583355006884	inhibitor-cofactor binding pocket; inhibition site
583355006885	pyridoxal 5'-phosphate binding site [chemical binding]; other site
583355006886	catalytic residue [active]
583355006887	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
583355006888	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
583355006889	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
583355006890	putative acyl-acceptor binding pocket; other site
583355006891	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
583355006892	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
583355006893	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
583355006894	active site
583355006895	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
583355006896	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
583355006897	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
583355006898	active site
583355006899	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
583355006900	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
583355006901	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
583355006902	metal-binding site
583355006903	Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852
583355006904	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
583355006905	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
583355006906	putative metal binding site; other site
583355006907	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
583355006908	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
583355006909	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
583355006910	Ligand binding site; other site
583355006911	Putative Catalytic site; other site
583355006912	DXD motif; other site
583355006913	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
583355006914	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
583355006915	putative ADP-binding pocket [chemical binding]; other site
583355006916	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
583355006917	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
583355006918	NAD binding site [chemical binding]; other site
583355006919	substrate binding site [chemical binding]; other site
583355006920	homodimer interface [polypeptide binding]; other site
583355006921	active site
583355006922	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
583355006923	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
583355006924	ATP binding site [chemical binding]; other site
583355006925	putative Mg++ binding site [ion binding]; other site
583355006926	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
583355006927	nucleotide binding region [chemical binding]; other site
583355006928	ATP-binding site [chemical binding]; other site
583355006929	seryl-tRNA synthetase; Provisional; Region: PRK05431
583355006930	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
583355006931	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
583355006932	dimer interface [polypeptide binding]; other site
583355006933	active site
583355006934	motif 1; other site
583355006935	motif 2; other site
583355006936	motif 3; other site
583355006937	prolyl-tRNA synthetase; Provisional; Region: PRK08661
583355006938	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
583355006939	dimer interface [polypeptide binding]; other site
583355006940	motif 1; other site
583355006941	active site
583355006942	motif 2; other site
583355006943	motif 3; other site
583355006944	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
583355006945	anticodon binding site; other site
583355006946	zinc-binding site [ion binding]; other site
583355006947	methionine sulfoxide reductase A; Provisional; Region: PRK14054
583355006948	Protein of unknown function (DUF493); Region: DUF493; pfam04359
583355006949	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
583355006950	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
583355006951	Nitrogen regulatory protein P-II; Region: P-II; smart00938
583355006952	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
583355006953	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
583355006954	Nitrogen regulatory protein P-II; Region: P-II; smart00938
583355006955	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
583355006956	NADH dehydrogenase subunit B; Provisional; Region: PRK14815
583355006957	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
583355006958	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
583355006959	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
583355006960	NADH dehydrogenase subunit D; Validated; Region: PRK06075
583355006961	NADH dehydrogenase subunit E; Validated; Region: PRK07539
583355006962	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
583355006963	putative dimer interface [polypeptide binding]; other site
583355006964	[2Fe-2S] cluster binding site [ion binding]; other site
583355006965	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
583355006966	SLBB domain; Region: SLBB; pfam10531
583355006967	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
583355006968	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
583355006969	four helix bundle protein; Region: TIGR02436
583355006970	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
583355006971	catalytic loop [active]
583355006972	iron binding site [ion binding]; other site
583355006973	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
583355006974	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
583355006975	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
583355006976	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
583355006977	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
583355006978	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143
583355006979	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
583355006980	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
583355006981	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
583355006982	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
583355006983	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
583355006984	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
583355006985	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
583355006986	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
583355006987	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
583355006988	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
583355006989	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
583355006990	Outer membrane efflux protein; Region: OEP; pfam02321
583355006991	Outer membrane efflux protein; Region: OEP; pfam02321
583355006992	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
583355006993	HlyD family secretion protein; Region: HlyD_3; pfam13437
583355006994	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
583355006995	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
583355006996	HlyD family secretion protein; Region: HlyD_3; pfam13437
583355006997	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
583355006998	Peptidase family M50; Region: Peptidase_M50; pfam02163
583355006999	active site
583355007000	putative substrate binding region [chemical binding]; other site
583355007001	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
583355007002	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
583355007003	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
583355007004	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
583355007005	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
583355007006	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
583355007007	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
583355007008	Domain of unknown function (DUF378); Region: DUF378; pfam04070
583355007009	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
583355007010	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
583355007011	homodimer interface [polypeptide binding]; other site
583355007012	substrate-cofactor binding pocket; other site
583355007013	pyridoxal 5'-phosphate binding site [chemical binding]; other site
583355007014	catalytic residue [active]
583355007015	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
583355007016	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
583355007017	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
583355007018	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
583355007019	active site
583355007020	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
583355007021	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
583355007022	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
583355007023	active site
583355007024	HIGH motif; other site
583355007025	KMSK motif region; other site
583355007026	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
583355007027	tRNA binding surface [nucleotide binding]; other site
583355007028	anticodon binding site; other site
583355007029	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
583355007030	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
583355007031	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
583355007032	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
583355007033	elongation factor P; Validated; Region: PRK00529
583355007034	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
583355007035	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
583355007036	RNA binding site [nucleotide binding]; other site
583355007037	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
583355007038	RNA binding site [nucleotide binding]; other site
583355007039	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
583355007040	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
583355007041	ligand binding site [chemical binding]; other site
583355007042	NAD binding site [chemical binding]; other site
583355007043	dimerization interface [polypeptide binding]; other site
583355007044	catalytic site [active]
583355007045	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
583355007046	putative L-serine binding site [chemical binding]; other site
583355007047	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
583355007048	homoserine dehydrogenase; Provisional; Region: PRK06349
583355007049	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
583355007050	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
583355007051	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
583355007052	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
583355007053	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
583355007054	ligand binding site [chemical binding]; other site
583355007055	flexible hinge region; other site
583355007056	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
583355007057	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
583355007058	active site
583355007059	metal binding site [ion binding]; metal-binding site
583355007060	aspartate kinase; Reviewed; Region: PRK06635
583355007061	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
583355007062	putative nucleotide binding site [chemical binding]; other site
583355007063	putative catalytic residues [active]
583355007064	putative Mg ion binding site [ion binding]; other site
583355007065	putative aspartate binding site [chemical binding]; other site
583355007066	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
583355007067	putative allosteric regulatory site; other site
583355007068	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
583355007069	putative allosteric regulatory residue; other site
583355007070	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
583355007071	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
583355007072	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
583355007073	pyridoxal 5'-phosphate binding site [chemical binding]; other site
583355007074	catalytic residue [active]
583355007075	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
583355007076	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
583355007077	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
583355007078	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
583355007079	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
583355007080	NusB family; Region: NusB; pfam01029
583355007081	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
583355007082	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355007083	S-adenosylmethionine binding site [chemical binding]; other site
583355007084	transcription elongation factor GreA; Region: greA; TIGR01462
583355007085	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
583355007086	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
583355007087	Protein of unknown function, DUF481; Region: DUF481; cl01213
583355007088	Protein of unknown function, DUF481; Region: DUF481; pfam04338
583355007089	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
583355007090	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
583355007091	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
583355007092	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
583355007093	active site
583355007094	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
583355007095	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
583355007096	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
583355007097	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
583355007098	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
583355007099	active site
583355007100	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
583355007101	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
583355007102	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
583355007103	active site
583355007104	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
583355007105	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
583355007106	active site
583355007107	metal binding site [ion binding]; metal-binding site
583355007108	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
583355007109	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
583355007110	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
583355007111	active site
583355007112	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
583355007113	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355007114	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355007115	Domain of unknown function DUF302; Region: DUF302; cl01364
583355007116	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
583355007117	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
583355007118	FtsX-like permease family; Region: FtsX; pfam02687
583355007119	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
583355007120	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
583355007121	Walker A/P-loop; other site
583355007122	ATP binding site [chemical binding]; other site
583355007123	Q-loop/lid; other site
583355007124	ABC transporter signature motif; other site
583355007125	Walker B; other site
583355007126	D-loop; other site
583355007127	H-loop/switch region; other site
583355007128	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
583355007129	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
583355007130	putative active site [active]
583355007131	catalytic site [active]
583355007132	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
583355007133	putative active site [active]
583355007134	catalytic site [active]
583355007135	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
583355007136	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
583355007137	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
583355007138	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
583355007139	ligand binding site [chemical binding]; other site
583355007140	flexible hinge region; other site
583355007141	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
583355007142	phosphopeptide binding site; other site
583355007143	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
583355007144	metal binding site [ion binding]; metal-binding site
583355007145	Acylphosphatase; Region: Acylphosphatase; pfam00708
583355007146	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
583355007147	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
583355007148	Walker A/P-loop; other site
583355007149	ATP binding site [chemical binding]; other site
583355007150	Q-loop/lid; other site
583355007151	ABC transporter signature motif; other site
583355007152	Walker B; other site
583355007153	D-loop; other site
583355007154	H-loop/switch region; other site
583355007155	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
583355007156	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
583355007157	TPR motif; other site
583355007158	binding surface
583355007159	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
583355007160	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
583355007161	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
583355007162	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
583355007163	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
583355007164	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
583355007165	NAD(P) binding site [chemical binding]; other site
583355007166	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
583355007167	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
583355007168	P-loop; other site
583355007169	Magnesium ion binding site [ion binding]; other site
583355007170	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
583355007171	Magnesium ion binding site [ion binding]; other site
583355007172	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
583355007173	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
583355007174	active site
583355007175	DNA binding site [nucleotide binding]
583355007176	Int/Topo IB signature motif; other site
583355007177	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
583355007178	N-terminal plug; other site
583355007179	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
583355007180	ligand-binding site [chemical binding]; other site
583355007181	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
583355007182	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
583355007183	active site
583355007184	catalytic tetrad [active]
583355007185	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
583355007186	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
583355007187	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
583355007188	Putative ATP-dependant zinc protease; Region: Zn_protease; pfam05618
583355007189	Domain of unknown function (DUF389); Region: DUF389; pfam04087
583355007190	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
583355007191	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
583355007192	Nucleoside recognition; Region: Gate; pfam07670
583355007193	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
583355007194	Ion transport protein; Region: Ion_trans; pfam00520
583355007195	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
583355007196	oligomeric interface; other site
583355007197	putative active site [active]
583355007198	homodimer interface [polypeptide binding]; other site
583355007199	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
583355007200	metabolite-proton symporter; Region: 2A0106; TIGR00883
583355007201	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
583355007202	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
583355007203	RNase E interface [polypeptide binding]; other site
583355007204	trimer interface [polypeptide binding]; other site
583355007205	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
583355007206	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
583355007207	RNase E interface [polypeptide binding]; other site
583355007208	trimer interface [polypeptide binding]; other site
583355007209	active site
583355007210	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
583355007211	putative nucleic acid binding region [nucleotide binding]; other site
583355007212	G-X-X-G motif; other site
583355007213	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
583355007214	RNA binding site [nucleotide binding]; other site
583355007215	domain interface; other site
583355007216	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
583355007217	16S/18S rRNA binding site [nucleotide binding]; other site
583355007218	S13e-L30e interaction site [polypeptide binding]; other site
583355007219	25S rRNA binding site [nucleotide binding]; other site
583355007220	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
583355007221	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
583355007222	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
583355007223	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
583355007224	binding surface
583355007225	TPR motif; other site
583355007226	TPR repeat; Region: TPR_11; pfam13414
583355007227	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
583355007228	binding surface
583355007229	TPR motif; other site
583355007230	Type II/IV secretion system protein; Region: T2SE; pfam00437
583355007231	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
583355007232	Walker A motif; other site
583355007233	ATP binding site [chemical binding]; other site
583355007234	Walker B motif; other site
583355007235	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
583355007236	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
583355007237	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
583355007238	Walker A/P-loop; other site
583355007239	ATP binding site [chemical binding]; other site
583355007240	Q-loop/lid; other site
583355007241	ABC transporter signature motif; other site
583355007242	Walker B; other site
583355007243	D-loop; other site
583355007244	H-loop/switch region; other site
583355007245	FtsX-like permease family; Region: FtsX; pfam02687
583355007246	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
583355007247	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
583355007248	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
583355007249	active site
583355007250	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
583355007251	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
583355007252	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
583355007253	putative metal binding site [ion binding]; other site
583355007254	Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]; Region: TNG2; COG5034
583355007255	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355007256	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355007257	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355007258	Sulfatase; Region: Sulfatase; cl17466
583355007259	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
583355007260	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
583355007261	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
583355007262	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
583355007263	Peptidase family U32; Region: Peptidase_U32; pfam01136
583355007264	Collagenase; Region: DUF3656; pfam12392
583355007265	Peptidase family U32; Region: Peptidase_U32; cl03113
583355007266	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
583355007267	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
583355007268	minor groove reading motif; other site
583355007269	helix-hairpin-helix signature motif; other site
583355007270	substrate binding pocket [chemical binding]; other site
583355007271	active site
583355007272	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
583355007273	nudix motif; other site
583355007274	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
583355007275	ThiC-associated domain; Region: ThiC-associated; pfam13667
583355007276	ThiC family; Region: ThiC; pfam01964
583355007277	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
583355007278	thiS-thiF/thiG interaction site; other site
583355007279	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
583355007280	thiamine phosphate binding site [chemical binding]; other site
583355007281	active site
583355007282	pyrophosphate binding site [ion binding]; other site
583355007283	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
583355007284	thiamine phosphate binding site [chemical binding]; other site
583355007285	active site
583355007286	pyrophosphate binding site [ion binding]; other site
583355007287	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
583355007288	ThiS interaction site; other site
583355007289	putative active site [active]
583355007290	tetramer interface [polypeptide binding]; other site
583355007291	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; cl16254
583355007292	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; cl16254
583355007293	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
583355007294	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
583355007295	FeS/SAM binding site; other site
583355007296	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
583355007297	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
583355007298	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
583355007299	ATP binding site [chemical binding]; other site
583355007300	substrate interface [chemical binding]; other site
583355007301	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
583355007302	active site residue [active]
583355007303	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
583355007304	dimer interface [polypeptide binding]; other site
583355007305	substrate binding site [chemical binding]; other site
583355007306	ATP binding site [chemical binding]; other site
583355007307	ribonuclease HIII; Provisional; Region: PRK00996
583355007308	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
583355007309	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
583355007310	RNA/DNA hybrid binding site [nucleotide binding]; other site
583355007311	active site
583355007312	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
583355007313	RNA/DNA hybrid binding site [nucleotide binding]; other site
583355007314	active site
583355007315	elongation factor Tu; Reviewed; Region: PRK00049
583355007316	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
583355007317	G1 box; other site
583355007318	GEF interaction site [polypeptide binding]; other site
583355007319	GTP/Mg2+ binding site [chemical binding]; other site
583355007320	Switch I region; other site
583355007321	G2 box; other site
583355007322	G3 box; other site
583355007323	Switch II region; other site
583355007324	G4 box; other site
583355007325	G5 box; other site
583355007326	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
583355007327	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
583355007328	Antibiotic Binding Site [chemical binding]; other site
583355007329	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
583355007330	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
583355007331	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
583355007332	putative homodimer interface [polypeptide binding]; other site
583355007333	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
583355007334	heterodimer interface [polypeptide binding]; other site
583355007335	homodimer interface [polypeptide binding]; other site
583355007336	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
583355007337	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
583355007338	23S rRNA interface [nucleotide binding]; other site
583355007339	L7/L12 interface [polypeptide binding]; other site
583355007340	putative thiostrepton binding site; other site
583355007341	L25 interface [polypeptide binding]; other site
583355007342	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
583355007343	mRNA/rRNA interface [nucleotide binding]; other site
583355007344	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
583355007345	23S rRNA interface [nucleotide binding]; other site
583355007346	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
583355007347	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
583355007348	core dimer interface [polypeptide binding]; other site
583355007349	peripheral dimer interface [polypeptide binding]; other site
583355007350	L10 interface [polypeptide binding]; other site
583355007351	L11 interface [polypeptide binding]; other site
583355007352	putative EF-Tu interaction site [polypeptide binding]; other site
583355007353	putative EF-G interaction site [polypeptide binding]; other site
583355007354	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563
583355007355	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
583355007356	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
583355007357	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
583355007358	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
583355007359	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
583355007360	RPB3 interaction site [polypeptide binding]; other site
583355007361	RPB1 interaction site [polypeptide binding]; other site
583355007362	RPB11 interaction site [polypeptide binding]; other site
583355007363	RPB10 interaction site [polypeptide binding]; other site
583355007364	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
583355007365	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
583355007366	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
583355007367	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
583355007368	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
583355007369	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
583355007370	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
583355007371	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
583355007372	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
583355007373	DNA binding site [nucleotide binding]
583355007374	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
583355007375	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
583355007376	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
583355007377	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
583355007378	Peptidase family M50; Region: Peptidase_M50; pfam02163
583355007379	active site
583355007380	putative substrate binding region [chemical binding]; other site
583355007381	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
583355007382	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
583355007383	non-specific DNA binding site [nucleotide binding]; other site
583355007384	salt bridge; other site
583355007385	sequence-specific DNA binding site [nucleotide binding]; other site
583355007386	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
583355007387	hypothetical protein; Provisional; Region: PRK11239
583355007388	Protein of unknown function, DUF480; Region: DUF480; pfam04337
583355007389	TspO/MBR family; Region: TspO_MBR; pfam03073
583355007390	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
583355007391	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
583355007392	Rhomboid family; Region: Rhomboid; pfam01694
583355007393	Uncharacterized conserved protein [Function unknown]; Region: COG1432
583355007394	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
583355007395	putative metal binding site [ion binding]; other site
583355007396	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
583355007397	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
583355007398	additional DNA contacts [nucleotide binding]; other site
583355007399	mismatch recognition site; other site
583355007400	active site
583355007401	zinc binding site [ion binding]; other site
583355007402	DNA intercalation site [nucleotide binding]; other site
583355007403	Restriction endonuclease; Region: Mrr_cat; pfam04471
583355007404	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
583355007405	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
583355007406	cofactor binding site; other site
583355007407	DNA binding site [nucleotide binding]
583355007408	substrate interaction site [chemical binding]; other site
583355007409	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
583355007410	AIPR protein; Region: AIPR; pfam10592
583355007411	Domain of unknown function (DUF4420); Region: DUF4420; pfam14390
583355007412	Z1 domain; Region: Z1; pfam10593
583355007413	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355007414	ATP binding site [chemical binding]; other site
583355007415	Mg2+ binding site [ion binding]; other site
583355007416	G-X-G motif; other site
583355007417	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
583355007418	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
583355007419	putative active site [active]
583355007420	Zn binding site [ion binding]; other site
583355007421	AAA ATPase domain; Region: AAA_16; pfam13191
583355007422	Archaeal ATPase; Region: Arch_ATPase; pfam01637
583355007423	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
583355007424	active site
583355007425	DoxX-like family; Region: DoxX_2; pfam13564
583355007426	SWIM zinc finger; Region: SWIM; pfam04434
583355007427	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
583355007428	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
583355007429	ATP binding site [chemical binding]; other site
583355007430	putative Mg++ binding site [ion binding]; other site
583355007431	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
583355007432	nucleotide binding region [chemical binding]; other site
583355007433	ATP-binding site [chemical binding]; other site
583355007434	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
583355007435	glutamine synthetase; Region: PLN02284
583355007436	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
583355007437	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
583355007438	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
583355007439	active site
583355007440	ATP binding site [chemical binding]; other site
583355007441	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
583355007442	Protein phosphatase 2C; Region: PP2C; pfam00481
583355007443	active site
583355007444	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
583355007445	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
583355007446	intersubunit interface [polypeptide binding]; other site
583355007447	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
583355007448	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
583355007449	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
583355007450	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
583355007451	ABC-ATPase subunit  interface; other site
583355007452	dimer interface [polypeptide binding]; other site
583355007453	putative PBP binding regions; other site
583355007454	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
583355007455	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
583355007456	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
583355007457	ABC-ATPase subunit  interface; other site
583355007458	dimer interface [polypeptide binding]; other site
583355007459	putative PBP binding regions; other site
583355007460	Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056
583355007461	Surface antigen; Region: Bac_surface_Ag; pfam01103
583355007462	hypothetical protein; Provisional; Region: PRK02947
583355007463	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
583355007464	putative active site [active]
583355007465	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
583355007466	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
583355007467	FMN binding site [chemical binding]; other site
583355007468	substrate binding site [chemical binding]; other site
583355007469	putative catalytic residue [active]
583355007470	Predicted permeases [General function prediction only]; Region: COG0679
583355007471	threonine dehydratase; Reviewed; Region: PRK09224
583355007472	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
583355007473	tetramer interface [polypeptide binding]; other site
583355007474	pyridoxal 5'-phosphate binding site [chemical binding]; other site
583355007475	catalytic residue [active]
583355007476	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
583355007477	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
583355007478	Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724
583355007479	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
583355007480	S-adenosylmethionine binding site [chemical binding]; other site
583355007481	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
583355007482	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
583355007483	DNA polymerase III subunit delta'; Validated; Region: PRK08485
583355007484	thymidylate kinase; Validated; Region: tmk; PRK00698
583355007485	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
583355007486	TMP-binding site; other site
583355007487	ATP-binding site [chemical binding]; other site
583355007488	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
583355007489	Domain of unknown function (DUF4020); Region: DUF4020; pfam13212
583355007490	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
583355007491	ATP binding site [chemical binding]; other site
583355007492	substrate binding site [chemical binding]; other site
583355007493	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
583355007494	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
583355007495	TolR protein; Region: tolR; TIGR02801
583355007496	TonB C terminal; Region: TonB_2; pfam13103
583355007497	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
583355007498	MarR family; Region: MarR_2; pfam12802
583355007499	MarR family; Region: MarR_2; cl17246
583355007500	DoxX; Region: DoxX; pfam07681
583355007501	Pirin-related protein [General function prediction only]; Region: COG1741
583355007502	Pirin; Region: Pirin; pfam02678
583355007503	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
583355007504	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
583355007505	FeS/SAM binding site; other site
583355007506	HemN C-terminal domain; Region: HemN_C; pfam06969
583355007507	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
583355007508	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
583355007509	DRTGG domain; Region: DRTGG; pfam07085
583355007510	DHHA2 domain; Region: DHHA2; pfam02833
583355007511	Sulfatase; Region: Sulfatase; cl17466
583355007512	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355007513	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
583355007514	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
583355007515	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
583355007516	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
583355007517	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
583355007518	ABC transporter; Region: ABC_tran_2; pfam12848
583355007519	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
583355007520	mannonate dehydratase; Provisional; Region: PRK03906
583355007521	mannonate dehydratase; Region: uxuA; TIGR00695
583355007522	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
583355007523	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
583355007524	putative NAD(P) binding site [chemical binding]; other site
583355007525	putative active site [active]
583355007526	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
583355007527	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
583355007528	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
583355007529	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355007530	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355007531	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
583355007532	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
583355007533	putative NAD(P) binding site [chemical binding]; other site
583355007534	dimer interface [polypeptide binding]; other site
583355007535	Uncharacterized conserved protein [Function unknown]; Region: COG1359
583355007536	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
583355007537	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355007538	NAD(P) binding site [chemical binding]; other site
583355007539	active site
583355007540	Trehalose utilisation; Region: ThuA; pfam06283
583355007541	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
583355007542	putative catalytic residues [active]
583355007543	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
583355007544	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
583355007545	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355007546	NAD(P) binding site [chemical binding]; other site
583355007547	active site
583355007548	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
583355007549	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
583355007550	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
583355007551	TrkA-N domain; Region: TrkA_N; pfam02254
583355007552	Protein of unknown function (DUF465); Region: DUF465; pfam04325
583355007553	FecR protein; Region: FecR; pfam04773
583355007554	RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989
583355007555	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
583355007556	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
583355007557	DNA binding residues [nucleotide binding]
583355007558	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
583355007559	catalytic triad [active]
583355007560	putative active site [active]
583355007561	PQQ-like domain; Region: PQQ_2; pfam13360
583355007562	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
583355007563	catalytic triad [active]
583355007564	putative active site [active]
583355007565	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
583355007566	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
583355007567	malate dehydrogenase; Provisional; Region: PRK05442
583355007568	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
583355007569	NAD(P) binding site [chemical binding]; other site
583355007570	dimer interface [polypeptide binding]; other site
583355007571	malate binding site [chemical binding]; other site
583355007572	malate:quinone oxidoreductase; Validated; Region: PRK05257
583355007573	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
583355007574	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
583355007575	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
583355007576	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
583355007577	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
583355007578	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
583355007579	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
583355007580	IHF - DNA interface [nucleotide binding]; other site
583355007581	IHF dimer interface [polypeptide binding]; other site
583355007582	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
583355007583	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
583355007584	substrate binding site [chemical binding]; other site
583355007585	ligand binding site [chemical binding]; other site
583355007586	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
583355007587	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
583355007588	substrate binding site [chemical binding]; other site
583355007589	ApbE family; Region: ApbE; pfam02424
583355007590	TIGR03663 family protein; Region: TIGR03663
583355007591	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
583355007592	active site
583355007593	PAS fold; Region: PAS_4; pfam08448
583355007594	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
583355007595	putative active site [active]
583355007596	heme pocket [chemical binding]; other site
583355007597	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
583355007598	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355007599	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
583355007600	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
583355007601	G1 box; other site
583355007602	GTP/Mg2+ binding site [chemical binding]; other site
583355007603	Switch I region; other site
583355007604	G2 box; other site
583355007605	G3 box; other site
583355007606	Switch II region; other site
583355007607	G4 box; other site
583355007608	G5 box; other site
583355007609	Nucleoside recognition; Region: Gate; pfam07670
583355007610	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
583355007611	Nucleoside recognition; Region: Gate; pfam07670
583355007612	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
583355007613	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
583355007614	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
583355007615	trimer interface [polypeptide binding]; other site
583355007616	putative metal binding site [ion binding]; other site
583355007617	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
583355007618	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
583355007619	ATP binding site [chemical binding]; other site
583355007620	Mg++ binding site [ion binding]; other site
583355007621	motif III; other site
583355007622	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
583355007623	nucleotide binding region [chemical binding]; other site
583355007624	ATP-binding site [chemical binding]; other site
583355007625	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
583355007626	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
583355007627	putative substrate translocation pore; other site
583355007628	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
583355007629	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
583355007630	Helix-turn-helix domain; Region: HTH_18; pfam12833
583355007631	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355007632	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
583355007633	Transcriptional regulators [Transcription]; Region: PurR; COG1609
583355007634	Helix-turn-helix domain; Region: HTH_18; pfam12833
583355007635	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355007636	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
583355007637	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
583355007638	putative active site [active]
583355007639	putative metal binding site [ion binding]; other site
583355007640	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
583355007641	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
583355007642	GAF domain; Region: GAF; pfam01590
583355007643	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
583355007644	Walker A motif; other site
583355007645	ATP binding site [chemical binding]; other site
583355007646	Walker B motif; other site
583355007647	arginine finger; other site
583355007648	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
583355007649	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
583355007650	Coenzyme A binding pocket [chemical binding]; other site
583355007651	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
583355007652	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
583355007653	active site
583355007654	catalytic residues [active]
583355007655	metal binding site [ion binding]; metal-binding site
583355007656	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
583355007657	dimer interface [polypeptide binding]; other site
583355007658	[2Fe-2S] cluster binding site [ion binding]; other site
583355007659	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
583355007660	Ferritin-like domain; Region: Ferritin; pfam00210
583355007661	ferroxidase diiron center [ion binding]; other site
583355007662	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
583355007663	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
583355007664	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
583355007665	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
583355007666	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
583355007667	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
583355007668	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
583355007669	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
583355007670	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
583355007671	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
583355007672	nitrogenase reductase; Reviewed; Region: nifH; PRK13235
583355007673	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
583355007674	Nucleotide-binding sites [chemical binding]; other site
583355007675	Walker A motif; other site
583355007676	Switch I region of nucleotide binding site; other site
583355007677	Fe4S4 binding sites [ion binding]; other site
583355007678	Switch II region of nucleotide binding site; other site
583355007679	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
583355007680	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
583355007681	dimer interface [polypeptide binding]; other site
583355007682	PYR/PP interface [polypeptide binding]; other site
583355007683	TPP binding site [chemical binding]; other site
583355007684	substrate binding site [chemical binding]; other site
583355007685	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
583355007686	Domain of unknown function; Region: EKR; smart00890
583355007687	4Fe-4S binding domain; Region: Fer4_6; pfam12837
583355007688	4Fe-4S binding domain; Region: Fer4; pfam00037
583355007689	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
583355007690	TPP-binding site [chemical binding]; other site
583355007691	dimer interface [polypeptide binding]; other site
583355007692	Flavodoxin; Region: Flavodoxin_1; pfam00258
583355007693	Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357
583355007694	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
583355007695	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
583355007696	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
583355007697	heme-binding site [chemical binding]; other site
583355007698	Family of unknown function (DUF490); Region: DUF490; pfam04357
583355007699	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
583355007700	Surface antigen; Region: Bac_surface_Ag; pfam01103
583355007701	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_2; cd13149
583355007702	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
583355007703	excinuclease ABC subunit B; Provisional; Region: PRK05298
583355007704	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
583355007705	ATP binding site [chemical binding]; other site
583355007706	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
583355007707	nucleotide binding region [chemical binding]; other site
583355007708	ATP-binding site [chemical binding]; other site
583355007709	Ultra-violet resistance protein B; Region: UvrB; pfam12344
583355007710	gamma-glutamyl kinase; Provisional; Region: PRK05429
583355007711	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
583355007712	nucleotide binding site [chemical binding]; other site
583355007713	homotetrameric interface [polypeptide binding]; other site
583355007714	putative phosphate binding site [ion binding]; other site
583355007715	putative allosteric binding site; other site
583355007716	PUA domain; Region: PUA; pfam01472
583355007717	ribosome recycling factor; Reviewed; Region: frr; PRK00083
583355007718	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
583355007719	hinge region; other site
583355007720	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
583355007721	putative nucleotide binding site [chemical binding]; other site
583355007722	uridine monophosphate binding site [chemical binding]; other site
583355007723	homohexameric interface [polypeptide binding]; other site
583355007724	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
583355007725	active site
583355007726	catalytic triad [active]
583355007727	oxyanion hole [active]
583355007728	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
583355007729	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172
583355007730	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
583355007731	putative ligand binding site [chemical binding]; other site
583355007732	putative NAD binding site [chemical binding]; other site
583355007733	catalytic site [active]
583355007734	Glucuronate isomerase; Region: UxaC; pfam02614
583355007735	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
583355007736	D-mannonate oxidoreductase; Provisional; Region: PRK08277
583355007737	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
583355007738	NAD(P) binding site [chemical binding]; other site
583355007739	active site
583355007740	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
583355007741	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355007742	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
583355007743	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355007744	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
583355007745	Domain of unknown function (DUF4202); Region: DUF4202; pfam13875
583355007746	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
583355007747	Peptidase family U32; Region: Peptidase_U32; pfam01136
583355007748	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
583355007749	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
583355007750	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
583355007751	Phosphotransferase enzyme family; Region: APH; pfam01636
583355007752	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
583355007753	active site
583355007754	substrate binding site [chemical binding]; other site
583355007755	ATP binding site [chemical binding]; other site
583355007756	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
583355007757	substrate binding site [chemical binding]; other site
583355007758	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
583355007759	Low molecular weight phosphatase family; Region: LMWPc; cd00115
583355007760	active site
583355007761	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
583355007762	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
583355007763	FMN binding site [chemical binding]; other site
583355007764	active site
583355007765	catalytic residues [active]
583355007766	substrate binding site [chemical binding]; other site
583355007767	Transposase IS200 like; Region: Y1_Tnp; cl00848
583355007768	Mechanosensitive ion channel; Region: MS_channel; pfam00924
583355007769	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
583355007770	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
583355007771	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
583355007772	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
583355007773	DXD motif; other site
583355007774	Transcriptional regulator [Transcription]; Region: LysR; COG0583
583355007775	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
583355007776	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
583355007777	dimerization interface [polypeptide binding]; other site
583355007778	peroxiredoxin; Region: AhpC; TIGR03137
583355007779	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
583355007780	dimer interface [polypeptide binding]; other site
583355007781	decamer (pentamer of dimers) interface [polypeptide binding]; other site
583355007782	catalytic triad [active]
583355007783	peroxidatic and resolving cysteines [active]
583355007784	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
583355007785	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
583355007786	catalytic residue [active]
583355007787	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
583355007788	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
583355007789	RibD C-terminal domain; Region: RibD_C; cl17279
583355007790	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
583355007791	Protein of unknown function (DUF1444); Region: DUF1444; cl02011
583355007792	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
583355007793	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
583355007794	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
583355007795	Mu-like prophage protein gp29 [Function unknown]; Region: COG4383
583355007796	integron integrase; Region: integrase_gron; TIGR02249
583355007797	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
583355007798	active site
583355007799	DNA binding site [nucleotide binding]
583355007800	Int/Topo IB signature motif; other site
583355007801	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
583355007802	Transposase; Region: DEDD_Tnp_IS110; pfam01548
583355007803	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
583355007804	Cytochrome c552; Region: Cytochrom_C552; pfam02335
583355007805	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
583355007806	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
583355007807	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
583355007808	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
583355007809	inhibitor-cofactor binding pocket; inhibition site
583355007810	pyridoxal 5'-phosphate binding site [chemical binding]; other site
583355007811	catalytic residue [active]
583355007812	NAD synthetase; Provisional; Region: PRK13981
583355007813	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
583355007814	multimer interface [polypeptide binding]; other site
583355007815	active site
583355007816	catalytic triad [active]
583355007817	protein interface 1 [polypeptide binding]; other site
583355007818	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
583355007819	homodimer interface [polypeptide binding]; other site
583355007820	NAD binding pocket [chemical binding]; other site
583355007821	ATP binding pocket [chemical binding]; other site
583355007822	Mg binding site [ion binding]; other site
583355007823	active-site loop [active]
583355007824	Maf-like protein; Region: Maf; pfam02545
583355007825	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
583355007826	active site
583355007827	dimer interface [polypeptide binding]; other site
583355007828	Gram-negative bacterial tonB protein; Region: TonB; cl10048
583355007829	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
583355007830	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
583355007831	active site
583355007832	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
583355007833	amphipathic channel; other site
583355007834	Asn-Pro-Ala signature motifs; other site
583355007835	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
583355007836	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355007837	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355007838	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
583355007839	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
583355007840	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
583355007841	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355007842	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355007843	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
583355007844	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
583355007845	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
583355007846	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
583355007847	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355007848	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355007849	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
583355007850	non-specific DNA interactions [nucleotide binding]; other site
583355007851	DNA binding site [nucleotide binding]
583355007852	sequence specific DNA binding site [nucleotide binding]; other site
583355007853	putative cAMP binding site [chemical binding]; other site
583355007854	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
583355007855	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
583355007856	nucleotide binding site [chemical binding]; other site
583355007857	PAS fold; Region: PAS_4; pfam08448
583355007858	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
583355007859	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355007860	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355007861	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355007862	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
583355007863	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
583355007864	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
583355007865	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
583355007866	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
583355007867	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
583355007868	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
583355007869	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
583355007870	Trehalose utilisation; Region: ThuA; pfam06283
583355007871	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
583355007872	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
583355007873	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
583355007874	Transposase; Region: DEDD_Tnp_IS110; pfam01548
583355007875	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
583355007876	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
583355007877	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
583355007878	FtsX-like permease family; Region: FtsX; pfam02687
583355007879	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
583355007880	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
583355007881	Walker A/P-loop; other site
583355007882	ATP binding site [chemical binding]; other site
583355007883	Q-loop/lid; other site
583355007884	ABC transporter signature motif; other site
583355007885	Walker B; other site
583355007886	D-loop; other site
583355007887	H-loop/switch region; other site
583355007888	HlyD family secretion protein; Region: HlyD_3; pfam13437
583355007889	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
583355007890	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
583355007891	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
583355007892	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
583355007893	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
583355007894	TPP-binding site [chemical binding]; other site
583355007895	dimer interface [polypeptide binding]; other site
583355007896	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
583355007897	PYR/PP interface [polypeptide binding]; other site
583355007898	dimer interface [polypeptide binding]; other site
583355007899	TPP binding site [chemical binding]; other site
583355007900	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
583355007901	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
583355007902	Lipopolysaccharide-assembly; Region: LptE; pfam04390
583355007903	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
583355007904	binding surface
583355007905	Tetratricopeptide repeat; Region: TPR_16; pfam13432
583355007906	TPR motif; other site
583355007907	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
583355007908	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
583355007909	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
583355007910	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
583355007911	dimer interface [polypeptide binding]; other site
583355007912	active site
583355007913	CoA binding pocket [chemical binding]; other site
583355007914	putative phosphate acyltransferase; Provisional; Region: PRK05331
583355007915	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
583355007916	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
583355007917	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
583355007918	conserved cys residue [active]
583355007919	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
583355007920	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
583355007921	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
583355007922	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
583355007923	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314
583355007924	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
583355007925	active site
583355007926	substrate binding site [chemical binding]; other site
583355007927	metal binding site [ion binding]; metal-binding site
583355007928	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
583355007929	TPR motif; other site
583355007930	binding surface
583355007931	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
583355007932	active site
583355007933	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
583355007934	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
583355007935	active site
583355007936	intersubunit interface [polypeptide binding]; other site
583355007937	zinc binding site [ion binding]; other site
583355007938	Na+ binding site [ion binding]; other site
583355007939	ParB-like nuclease domain; Region: ParB; smart00470
583355007940	Peptidase family M48; Region: Peptidase_M48; pfam01435
583355007941	hypothetical protein; Provisional; Region: PRK08201
583355007942	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
583355007943	metal binding site [ion binding]; metal-binding site
583355007944	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
583355007945	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
583355007946	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
583355007947	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
583355007948	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
583355007949	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
583355007950	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
583355007951	Vi polysaccharide biosynthesis protein TviE; Provisional; Region: PRK15179
583355007952	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
583355007953	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
583355007954	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
583355007955	ABC transporter; Region: ABC_tran_2; pfam12848
583355007956	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
583355007957	ABC transporter; Region: ABC_tran_2; pfam12848
583355007958	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
583355007959	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
583355007960	Walker A/P-loop; other site
583355007961	ATP binding site [chemical binding]; other site
583355007962	Q-loop/lid; other site
583355007963	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
583355007964	ABC transporter signature motif; other site
583355007965	Walker B; other site
583355007966	D-loop; other site
583355007967	H-loop/switch region; other site
583355007968	Major Facilitator Superfamily; Region: MFS_1; pfam07690
583355007969	Quinolinate synthetase A protein; Region: NadA; pfam02445
583355007970	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
583355007971	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
583355007972	23S rRNA binding site [nucleotide binding]; other site
583355007973	L21 binding site [polypeptide binding]; other site
583355007974	L13 binding site [polypeptide binding]; other site
583355007975	Clp protease; Region: CLP_protease; pfam00574
583355007976	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
583355007977	oligomer interface [polypeptide binding]; other site
583355007978	active site residues [active]
583355007979	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
583355007980	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
583355007981	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
583355007982	Domain of unknown function DUF59; Region: DUF59; pfam01883
583355007983	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
583355007984	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
583355007985	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
583355007986	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
583355007987	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
583355007988	Ion channel; Region: Ion_trans_2; pfam07885
583355007989	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
583355007990	Fatty acid desaturase; Region: FA_desaturase; pfam00487
583355007991	Di-iron ligands [ion binding]; other site
583355007992	Prefoldin subunit; Region: Prefoldin_2; pfam01920
583355007993	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
583355007994	Mechanosensitive ion channel; Region: MS_channel; pfam00924
583355007995	glutaminase; Reviewed; Region: PRK12356
583355007996	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
583355007997	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
583355007998	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
583355007999	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
583355008000	Phosphoglycerate kinase; Region: PGK; pfam00162
583355008001	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
583355008002	substrate binding site [chemical binding]; other site
583355008003	hinge regions; other site
583355008004	ADP binding site [chemical binding]; other site
583355008005	catalytic site [active]
583355008006	triosephosphate isomerase; Provisional; Region: PRK14565
583355008007	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
583355008008	substrate binding site [chemical binding]; other site
583355008009	dimer interface [polypeptide binding]; other site
583355008010	catalytic triad [active]
583355008011	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
583355008012	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
583355008013	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
583355008014	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
583355008015	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
583355008016	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
583355008017	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
583355008018	RIP metalloprotease RseP; Region: TIGR00054
583355008019	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
583355008020	active site
583355008021	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
583355008022	protein binding site [polypeptide binding]; other site
583355008023	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
583355008024	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
583355008025	putative substrate binding region [chemical binding]; other site
583355008026	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
583355008027	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
583355008028	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
583355008029	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
583355008030	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
583355008031	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
583355008032	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
583355008033	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
583355008034	catalytic residue [active]
583355008035	putative FPP diphosphate  binding site; other site
583355008036	putative FPP binding hydrophobic cleft; other site
583355008037	dimer interface [polypeptide binding]; other site
583355008038	putative IPP diphosphate binding site; other site
583355008039	Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834
583355008040	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
583355008041	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
583355008042	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
583355008043	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
583355008044	ribonuclease PH; Reviewed; Region: rph; PRK00173
583355008045	Ribonuclease PH; Region: RNase_PH_bact; cd11362
583355008046	hexamer interface [polypeptide binding]; other site
583355008047	active site
583355008048	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
583355008049	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
583355008050	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
583355008051	ATP binding site [chemical binding]; other site
583355008052	Mg++ binding site [ion binding]; other site
583355008053	motif III; other site
583355008054	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
583355008055	nucleotide binding region [chemical binding]; other site
583355008056	ATP-binding site [chemical binding]; other site
583355008057	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
583355008058	Verru_Chthon cassette protein B; Region: TIGR02598
583355008059	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
583355008060	Verru_Chthon cassette protein C; Region: TIGR02599
583355008061	DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141
583355008062	catalytic site [active]
583355008063	putative active site [active]
583355008064	putative substrate binding site [chemical binding]; other site
583355008065	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
583355008066	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
583355008067	Isochorismatase family; Region: Isochorismatase; pfam00857
583355008068	catalytic triad [active]
583355008069	conserved cis-peptide bond; other site
583355008070	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
583355008071	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
583355008072	active site
583355008073	metal binding site [ion binding]; metal-binding site
583355008074	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
583355008075	Peptidase family M23; Region: Peptidase_M23; pfam01551
583355008076	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
583355008077	intersubunit interface [polypeptide binding]; other site
583355008078	active site
583355008079	catalytic residue [active]
583355008080	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
583355008081	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
583355008082	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
583355008083	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
583355008084	purine nucleoside phosphorylase; Provisional; Region: PRK08202
583355008085	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
583355008086	active site
583355008087	Amidase; Region: Amidase; cl11426
583355008088	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
583355008089	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
583355008090	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355008091	ATP binding site [chemical binding]; other site
583355008092	Mg2+ binding site [ion binding]; other site
583355008093	G-X-G motif; other site
583355008094	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
583355008095	ATP binding site [chemical binding]; other site
583355008096	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
583355008097	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
583355008098	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
583355008099	catalytic residues [active]
583355008100	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
583355008101	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
583355008102	ATP binding site [chemical binding]; other site
583355008103	Walker B motif; other site
583355008104	argininosuccinate lyase; Provisional; Region: PRK00855
583355008105	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
583355008106	active sites [active]
583355008107	tetramer interface [polypeptide binding]; other site
583355008108	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
583355008109	active site
583355008110	dimerization interface [polypeptide binding]; other site
583355008111	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
583355008112	active site
583355008113	substrate binding pocket [chemical binding]; other site
583355008114	dimer interface [polypeptide binding]; other site
583355008115	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
583355008116	Transcriptional regulator [Transcription]; Region: IclR; COG1414
583355008117	Bacterial transcriptional regulator; Region: IclR; pfam01614
583355008118	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
583355008119	tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791
583355008120	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
583355008121	lysophospholipid transporter LplT; Provisional; Region: PRK11195
583355008122	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
583355008123	putative substrate translocation pore; other site
583355008124	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
583355008125	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
583355008126	putative acyl-acceptor binding pocket; other site
583355008127	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
583355008128	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
583355008129	ATP-grasp domain; Region: ATP-grasp; pfam02222
583355008130	Transposase IS200 like; Region: Y1_Tnp; cl00848
583355008131	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
583355008132	Domain of unknown function DUF20; Region: UPF0118; pfam01594
583355008133	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
583355008134	active site
583355008135	catalytic triad [active]
583355008136	oxyanion hole [active]
583355008137	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
583355008138	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
583355008139	NAD binding site [chemical binding]; other site
583355008140	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
583355008141	LssY C-terminus; Region: LssY_C; pfam14067
583355008142	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
583355008143	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
583355008144	apolar tunnel; other site
583355008145	heme binding site [chemical binding]; other site
583355008146	dimerization interface [polypeptide binding]; other site
583355008147	Protein of unknown function (DUF497); Region: DUF497; pfam04365
583355008148	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
583355008149	MraZ protein; Region: MraZ; pfam02381
583355008150	MraZ protein; Region: MraZ; pfam02381
583355008151	MraW methylase family; Region: Methyltransf_5; cl17771
583355008152	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
583355008153	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
583355008154	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
583355008155	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
583355008156	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
583355008157	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
583355008158	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
583355008159	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
583355008160	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
583355008161	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
583355008162	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
583355008163	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
583355008164	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
583355008165	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
583355008166	Mg++ binding site [ion binding]; other site
583355008167	putative catalytic motif [active]
583355008168	putative substrate binding site [chemical binding]; other site
583355008169	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
583355008170	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
583355008171	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
583355008172	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
583355008173	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
583355008174	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
583355008175	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
583355008176	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
583355008177	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
583355008178	cell division protein FtsW; Region: ftsW; TIGR02614
583355008179	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
583355008180	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
583355008181	active site
583355008182	homodimer interface [polypeptide binding]; other site
583355008183	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
583355008184	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
583355008185	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
583355008186	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
583355008187	FAD binding domain; Region: FAD_binding_4; pfam01565
583355008188	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
583355008189	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
583355008190	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
583355008191	ATP-grasp domain; Region: ATP-grasp_4; cl17255
583355008192	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
583355008193	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
583355008194	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
583355008195	Cell division protein FtsA; Region: FtsA; smart00842
583355008196	Cell division protein FtsA; Region: FtsA; pfam14450
583355008197	cell division protein FtsZ; Validated; Region: PRK09330
583355008198	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
583355008199	nucleotide binding site [chemical binding]; other site
583355008200	SulA interaction site; other site
583355008201	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
583355008202	reverse gyrase; Reviewed; Region: PRK09401
583355008203	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
583355008204	Lamin Tail Domain; Region: LTD; pfam00932
583355008205	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
583355008206	CotH protein; Region: CotH; pfam08757
583355008207	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
583355008208	Lamin Tail Domain; Region: LTD; pfam00932
583355008209	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
583355008210	putative metal binding residues [ion binding]; other site
583355008211	signature motif; other site
583355008212	dimer interface [polypeptide binding]; other site
583355008213	active site
583355008214	polyP binding site; other site
583355008215	substrate binding site [chemical binding]; other site
583355008216	acceptor-phosphate pocket; other site
583355008217	hypothetical protein; Region: PHA02446
583355008218	HlyD family secretion protein; Region: HlyD; pfam00529
583355008219	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
583355008220	HlyD family secretion protein; Region: HlyD_3; pfam13437
583355008221	Outer membrane efflux protein; Region: OEP; pfam02321
583355008222	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
583355008223	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
583355008224	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355008225	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
583355008226	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
583355008227	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
583355008228	Right handed beta helix region; Region: Beta_helix; pfam13229
583355008229	Protein kinase domain; Region: Pkinase; pfam00069
583355008230	Catalytic domain of Protein Kinases; Region: PKc; cd00180
583355008231	active site
583355008232	ATP binding site [chemical binding]; other site
583355008233	substrate binding site [chemical binding]; other site
583355008234	activation loop (A-loop); other site
583355008235	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
583355008236	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
583355008237	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
583355008238	active site
583355008239	catalytic residues [active]
583355008240	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
583355008241	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355008242	Sulfatase; Region: Sulfatase; pfam00884
583355008243	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
583355008244	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
583355008245	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
583355008246	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
583355008247	active site
583355008248	phosphorylation site [posttranslational modification]
583355008249	intermolecular recognition site; other site
583355008250	dimerization interface [polypeptide binding]; other site
583355008251	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
583355008252	DNA binding residues [nucleotide binding]
583355008253	dimerization interface [polypeptide binding]; other site
583355008254	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
583355008255	Histidine kinase; Region: HisKA_3; pfam07730
583355008256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
583355008257	ATP binding site [chemical binding]; other site
583355008258	Mg2+ binding site [ion binding]; other site
583355008259	G-X-G motif; other site
583355008260	Sulfatase; Region: Sulfatase; cl17466
583355008261	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
583355008262	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
583355008263	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
583355008264	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
583355008265	dimer interface [polypeptide binding]; other site
583355008266	anticodon binding site; other site
583355008267	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
583355008268	homodimer interface [polypeptide binding]; other site
583355008269	motif 1; other site
583355008270	active site
583355008271	motif 2; other site
583355008272	GAD domain; Region: GAD; pfam02938
583355008273	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
583355008274	active site
583355008275	motif 3; other site
583355008276	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
583355008277	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
583355008278	OstA-like protein; Region: OstA; cl00844
583355008279	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
583355008280	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
583355008281	Walker A/P-loop; other site
583355008282	ATP binding site [chemical binding]; other site
583355008283	Q-loop/lid; other site
583355008284	ABC transporter signature motif; other site
583355008285	Walker B; other site
583355008286	D-loop; other site
583355008287	H-loop/switch region; other site
583355008288	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
583355008289	Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679
583355008290	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
583355008291	Hpr binding site; other site
583355008292	active site
583355008293	homohexamer subunit interaction site [polypeptide binding]; other site