-- dump date   	20140619_050432
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
700015000001	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700015000002	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700015000003	ATP binding site [chemical binding]; other site
700015000004	Mg2+ binding site [ion binding]; other site
700015000005	G-X-G motif; other site
700015000006	Transcriptional regulators [Transcription]; Region: MarR; COG1846
700015000007	helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418
700015000008	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
700015000009	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700015000010	Walker A motif; other site
700015000011	ATP binding site [chemical binding]; other site
700015000012	Walker B motif; other site
700015000013	arginine finger; other site
700015000014	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
700015000015	DnaA box-binding interface [nucleotide binding]; other site
700015000016	DNA polymerase III subunit beta; Validated; Region: PRK05643
700015000017	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
700015000018	putative DNA binding surface [nucleotide binding]; other site
700015000019	dimer interface [polypeptide binding]; other site
700015000020	beta-clamp/clamp loader binding surface; other site
700015000021	beta-clamp/translesion DNA polymerase binding surface; other site
700015000022	recombination protein F; Reviewed; Region: recF; PRK00064
700015000023	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015000024	Walker A/P-loop; other site
700015000025	ATP binding site [chemical binding]; other site
700015000026	Q-loop/lid; other site
700015000027	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015000028	ABC transporter signature motif; other site
700015000029	Walker B; other site
700015000030	D-loop; other site
700015000031	H-loop/switch region; other site
700015000032	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
700015000033	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700015000034	ATP binding site [chemical binding]; other site
700015000035	Mg2+ binding site [ion binding]; other site
700015000036	G-X-G motif; other site
700015000037	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
700015000038	anchoring element; other site
700015000039	dimer interface [polypeptide binding]; other site
700015000040	ATP binding site [chemical binding]; other site
700015000041	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
700015000042	active site
700015000043	putative metal-binding site [ion binding]; other site
700015000044	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
700015000045	DNA gyrase subunit A; Validated; Region: PRK05560
700015000046	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
700015000047	CAP-like domain; other site
700015000048	active site
700015000049	primary dimer interface [polypeptide binding]; other site
700015000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
700015000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
700015000052	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
700015000053	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
700015000054	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
700015000055	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
700015000056	Bifunctional nuclease; Region: DNase-RNase; pfam02577
700015000057	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
700015000058	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700015000059	motif II; other site
700015000060	Domain of unknown function (DUF4176); Region: DUF4176; pfam13780
700015000061	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
700015000062	Domain of unknown function (DUF4176); Region: DUF4176; pfam13780
700015000063	Domain of unknown function (DUF4176); Region: DUF4176; cl01867
700015000064	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
700015000065	homodimer interaction site [polypeptide binding]; other site
700015000066	cofactor binding site; other site
700015000067	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
700015000068	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
700015000069	DNA binding residues [nucleotide binding]
700015000070	drug binding residues [chemical binding]; other site
700015000071	dimer interface [polypeptide binding]; other site
700015000072	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
700015000073	adenylosuccinate lyase; Provisional; Region: PRK07492
700015000074	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
700015000075	tetramer interface [polypeptide binding]; other site
700015000076	active site
700015000077	Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397
700015000078	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700015000079	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700015000080	active site
700015000081	phosphorylation site [posttranslational modification]
700015000082	intermolecular recognition site; other site
700015000083	dimerization interface [polypeptide binding]; other site
700015000084	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700015000085	DNA binding site [nucleotide binding]
700015000086	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700015000087	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700015000088	dimerization interface [polypeptide binding]; other site
700015000089	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700015000090	dimer interface [polypeptide binding]; other site
700015000091	phosphorylation site [posttranslational modification]
700015000092	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700015000093	ATP binding site [chemical binding]; other site
700015000094	Mg2+ binding site [ion binding]; other site
700015000095	G-X-G motif; other site
700015000096	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
700015000097	active site
700015000098	ATP binding site [chemical binding]; other site
700015000099	substrate binding site [chemical binding]; other site
700015000100	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
700015000101	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
700015000102	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
700015000103	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
700015000104	active site
700015000105	substrate binding site [chemical binding]; other site
700015000106	metal binding site [ion binding]; metal-binding site
700015000107	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
700015000108	alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175
700015000109	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
700015000110	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
700015000111	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
700015000112	Ligand Binding Site [chemical binding]; other site
700015000113	TilS substrate C-terminal domain; Region: TilS_C; smart00977
700015000114	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
700015000115	active pocket/dimerization site; other site
700015000116	active site
700015000117	phosphorylation site [posttranslational modification]
700015000118	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021
700015000119	active site
700015000120	phosphorylation site [posttranslational modification]
700015000121	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
700015000122	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
700015000123	Transcriptional regulators [Transcription]; Region: MarR; COG1846
700015000124	MarR family; Region: MarR_2; pfam12802
700015000125	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700015000126	active site
700015000127	FtsH Extracellular; Region: FtsH_ext; pfam06480
700015000128	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
700015000129	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700015000130	Walker A motif; other site
700015000131	ATP binding site [chemical binding]; other site
700015000132	Walker B motif; other site
700015000133	arginine finger; other site
700015000134	Peptidase family M41; Region: Peptidase_M41; pfam01434
700015000135	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
700015000136	putative hydrolase; Validated; Region: PRK09248
700015000137	active site
700015000138	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
700015000139	active site flap/lid [active]
700015000140	nucleophilic elbow; other site
700015000141	catalytic triad [active]
700015000142	23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522
700015000143	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
700015000144	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
700015000145	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
700015000146	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
700015000147	T surface-antigen of pili; Region: FctA; pfam12892
700015000148	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
700015000149	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
700015000150	T surface-antigen of pili; Region: FctA; pfam12892
700015000151	T surface-antigen of pili; Region: FctA; pfam12892
700015000152	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
700015000153	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
700015000154	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
700015000155	elongation factor G; Reviewed; Region: PRK12740
700015000156	G1 box; other site
700015000157	putative GEF interaction site [polypeptide binding]; other site
700015000158	GTP/Mg2+ binding site [chemical binding]; other site
700015000159	Switch I region; other site
700015000160	G2 box; other site
700015000161	G3 box; other site
700015000162	Switch II region; other site
700015000163	G4 box; other site
700015000164	G5 box; other site
700015000165	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
700015000166	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
700015000167	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
700015000168	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700015000169	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700015000170	non-specific DNA binding site [nucleotide binding]; other site
700015000171	salt bridge; other site
700015000172	sequence-specific DNA binding site [nucleotide binding]; other site
700015000173	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
700015000174	dimer interface [polypeptide binding]; other site
700015000175	catalytic triad [active]
700015000176	Flavin Reductases; Region: FlaRed; cl00801
700015000177	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
700015000178	catalytic core [active]
700015000179	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700015000180	Coenzyme A binding pocket [chemical binding]; other site
700015000181	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
700015000182	endonuclease III; Region: ENDO3c; smart00478
700015000183	minor groove reading motif; other site
700015000184	helix-hairpin-helix signature motif; other site
700015000185	substrate binding pocket [chemical binding]; other site
700015000186	active site
700015000187	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
700015000188	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
700015000189	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
700015000190	DNA binding site [nucleotide binding]
700015000191	active site
700015000192	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015000193	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
700015000194	Walker A/P-loop; other site
700015000195	ATP binding site [chemical binding]; other site
700015000196	Q-loop/lid; other site
700015000197	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015000198	ABC transporter signature motif; other site
700015000199	Walker B; other site
700015000200	D-loop; other site
700015000201	H-loop/switch region; other site
700015000202	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015000203	Walker A/P-loop; other site
700015000204	ATP binding site [chemical binding]; other site
700015000205	Q-loop/lid; other site
700015000206	ABC transporter signature motif; other site
700015000207	Walker B; other site
700015000208	D-loop; other site
700015000209	H-loop/switch region; other site
700015000210	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
700015000211	dimer interface [polypeptide binding]; other site
700015000212	FMN binding site [chemical binding]; other site
700015000213	Protein of unknown function (DUF805); Region: DUF805; cl01224
700015000214	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
700015000215	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
700015000216	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
700015000217	oligomer interface [polypeptide binding]; other site
700015000218	active site
700015000219	metal binding site [ion binding]; metal-binding site
700015000220	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
700015000221	Ligand Binding Site [chemical binding]; other site
700015000222	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700015000223	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700015000224	DNA binding site [nucleotide binding]
700015000225	domain linker motif; other site
700015000226	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700015000227	ligand binding site [chemical binding]; other site
700015000228	dimerization interface [polypeptide binding]; other site
700015000229	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
700015000230	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
700015000231	glutaminase active site [active]
700015000232	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
700015000233	dimer interface [polypeptide binding]; other site
700015000234	active site
700015000235	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
700015000236	dimer interface [polypeptide binding]; other site
700015000237	active site
700015000238	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
700015000239	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
700015000240	serine O-acetyltransferase; Region: cysE; TIGR01172
700015000241	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
700015000242	trimer interface [polypeptide binding]; other site
700015000243	active site
700015000244	substrate binding site [chemical binding]; other site
700015000245	CoA binding site [chemical binding]; other site
700015000246	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
700015000247	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
700015000248	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
700015000249	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
700015000250	homodimer interface [polypeptide binding]; other site
700015000251	substrate-cofactor binding pocket; other site
700015000252	catalytic residue [active]
700015000253	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
700015000254	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
700015000255	nucleoside/Zn binding site; other site
700015000256	dimer interface [polypeptide binding]; other site
700015000257	catalytic motif [active]
700015000258	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700015000259	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700015000260	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015000261	Walker A/P-loop; other site
700015000262	ATP binding site [chemical binding]; other site
700015000263	Q-loop/lid; other site
700015000264	ABC transporter signature motif; other site
700015000265	Walker B; other site
700015000266	D-loop; other site
700015000267	H-loop/switch region; other site
700015000268	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700015000269	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700015000270	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
700015000271	Walker A/P-loop; other site
700015000272	ATP binding site [chemical binding]; other site
700015000273	Q-loop/lid; other site
700015000274	ABC transporter signature motif; other site
700015000275	Walker B; other site
700015000276	D-loop; other site
700015000277	H-loop/switch region; other site
700015000278	Flavodoxin domain; Region: Flavodoxin_3; pfam12641
700015000279	K+ potassium transporter; Region: K_trans; pfam02705
700015000280	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
700015000281	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700015000282	S-adenosylmethionine binding site [chemical binding]; other site
700015000283	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700015000284	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700015000285	non-specific DNA binding site [nucleotide binding]; other site
700015000286	salt bridge; other site
700015000287	sequence-specific DNA binding site [nucleotide binding]; other site
700015000288	Cupin domain; Region: Cupin_2; pfam07883
700015000289	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
700015000290	POT family; Region: PTR2; cl17359
700015000291	POT family; Region: PTR2; cl17359
700015000292	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
700015000293	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015000294	POT family; Region: PTR2; cl17359
700015000295	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
700015000296	Zn binding site [ion binding]; other site
700015000297	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
700015000298	POT family; Region: PTR2; cl17359
700015000299	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015000300	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
700015000301	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700015000302	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
700015000303	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
700015000304	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
700015000305	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
700015000306	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
700015000307	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
700015000308	putative active site [active]
700015000309	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
700015000310	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
700015000311	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
700015000312	active site
700015000313	P-loop; other site
700015000314	phosphorylation site [posttranslational modification]
700015000315	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
700015000316	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700015000317	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700015000318	catalytic residue [active]
700015000319	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
700015000320	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015000321	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700015000322	putative substrate translocation pore; other site
700015000323	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015000324	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
700015000325	intersubunit interface [polypeptide binding]; other site
700015000326	active site
700015000327	zinc binding site [ion binding]; other site
700015000328	Na+ binding site [ion binding]; other site
700015000329	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
700015000330	active site
700015000331	phosphorylation site [posttranslational modification]
700015000332	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
700015000333	active site
700015000334	P-loop; other site
700015000335	phosphorylation site [posttranslational modification]
700015000336	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
700015000337	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700015000338	Tetratricopeptide repeat; Region: TPR_10; cl17452
700015000339	AAA domain; Region: AAA_33; pfam13671
700015000340	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
700015000341	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
700015000342	ATP binding site [chemical binding]; other site
700015000343	substrate binding site [chemical binding]; other site
700015000344	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
700015000345	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700015000346	DNA-binding site [nucleotide binding]; DNA binding site
700015000347	UTRA domain; Region: UTRA; pfam07702
700015000348	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700015000349	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700015000350	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
700015000351	Walker A/P-loop; other site
700015000352	ATP binding site [chemical binding]; other site
700015000353	Q-loop/lid; other site
700015000354	ABC transporter signature motif; other site
700015000355	Walker B; other site
700015000356	D-loop; other site
700015000357	H-loop/switch region; other site
700015000358	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700015000359	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700015000360	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015000361	Walker A/P-loop; other site
700015000362	ATP binding site [chemical binding]; other site
700015000363	Q-loop/lid; other site
700015000364	ABC transporter signature motif; other site
700015000365	Walker B; other site
700015000366	D-loop; other site
700015000367	H-loop/switch region; other site
700015000368	MarR family; Region: MarR; pfam01047
700015000369	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
700015000370	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
700015000371	nudix motif; other site
700015000372	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
700015000373	Protein of unknown function (DUF554); Region: DUF554; pfam04474
700015000374	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
700015000375	Flavoprotein; Region: Flavoprotein; pfam02441
700015000376	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
700015000377	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
700015000378	DNA binding residues [nucleotide binding]
700015000379	drug binding residues [chemical binding]; other site
700015000380	dimer interface [polypeptide binding]; other site
700015000381	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
700015000382	active site
700015000383	catalytic residues [active]
700015000384	peptide chain release factor 1; Validated; Region: prfA; PRK00591
700015000385	This domain is found in peptide chain release factors; Region: PCRF; smart00937
700015000386	RF-1 domain; Region: RF-1; pfam00472
700015000387	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
700015000388	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
700015000389	active site
700015000390	catalytic triad [active]
700015000391	oxyanion hole [active]
700015000392	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700015000393	active site
700015000394	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
700015000395	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
700015000396	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
700015000397	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
700015000398	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
700015000399	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
700015000400	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700015000401	motif II; other site
700015000402	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
700015000403	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700015000404	catalytic residues [active]
700015000405	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
700015000406	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
700015000407	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
700015000408	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
700015000409	nucleotide binding site [chemical binding]; other site
700015000410	NEF interaction site [polypeptide binding]; other site
700015000411	SBD interface [polypeptide binding]; other site
700015000412	GrpE; Region: GrpE; pfam01025
700015000413	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
700015000414	dimer interface [polypeptide binding]; other site
700015000415	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
700015000416	chaperone protein DnaJ; Provisional; Region: PRK14301
700015000417	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
700015000418	HSP70 interaction site [polypeptide binding]; other site
700015000419	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
700015000420	substrate binding site [polypeptide binding]; other site
700015000421	dimer interface [polypeptide binding]; other site
700015000422	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
700015000423	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
700015000424	DNA binding residues [nucleotide binding]
700015000425	putative dimer interface [polypeptide binding]; other site
700015000426	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
700015000427	Clp amino terminal domain; Region: Clp_N; pfam02861
700015000428	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700015000429	Walker A motif; other site
700015000430	ATP binding site [chemical binding]; other site
700015000431	Walker B motif; other site
700015000432	arginine finger; other site
700015000433	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700015000434	Walker A motif; other site
700015000435	ATP binding site [chemical binding]; other site
700015000436	Walker B motif; other site
700015000437	arginine finger; other site
700015000438	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
700015000439	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
700015000440	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700015000441	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700015000442	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
700015000443	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
700015000444	4Fe-4S binding domain; Region: Fer4; pfam00037
700015000445	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
700015000446	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
700015000447	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700015000448	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700015000449	4Fe-4S binding domain; Region: Fer4; pfam00037
700015000450	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
700015000451	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
700015000452	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
700015000453	Cna protein B-type domain; Region: Cna_B; pfam05738
700015000454	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
700015000455	active site
700015000456	catalytic site [active]
700015000457	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
700015000458	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
700015000459	peptide binding site [polypeptide binding]; other site
700015000460	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
700015000461	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700015000462	dimer interface [polypeptide binding]; other site
700015000463	conserved gate region; other site
700015000464	putative PBP binding loops; other site
700015000465	ABC-ATPase subunit interface; other site
700015000466	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
700015000467	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
700015000468	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700015000469	dimer interface [polypeptide binding]; other site
700015000470	conserved gate region; other site
700015000471	ABC-ATPase subunit interface; other site
700015000472	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
700015000473	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
700015000474	Walker A/P-loop; other site
700015000475	ATP binding site [chemical binding]; other site
700015000476	Q-loop/lid; other site
700015000477	ABC transporter signature motif; other site
700015000478	Walker B; other site
700015000479	D-loop; other site
700015000480	H-loop/switch region; other site
700015000481	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
700015000482	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
700015000483	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
700015000484	Walker A/P-loop; other site
700015000485	ATP binding site [chemical binding]; other site
700015000486	Q-loop/lid; other site
700015000487	ABC transporter signature motif; other site
700015000488	Walker B; other site
700015000489	D-loop; other site
700015000490	H-loop/switch region; other site
700015000491	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
700015000492	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
700015000493	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
700015000494	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
700015000495	putative active site [active]
700015000496	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
700015000497	beta-galactosidase; Region: BGL; TIGR03356
700015000498	PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796
700015000499	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
700015000500	active site turn [active]
700015000501	phosphorylation site [posttranslational modification]
700015000502	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
700015000503	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
700015000504	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
700015000505	active site
700015000506	dimer interface [polypeptide binding]; other site
700015000507	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
700015000508	Ligand Binding Site [chemical binding]; other site
700015000509	Molecular Tunnel; other site
700015000510	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
700015000511	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
700015000512	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
700015000513	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700015000514	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700015000515	active site
700015000516	phosphorylation site [posttranslational modification]
700015000517	intermolecular recognition site; other site
700015000518	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700015000519	DNA binding residues [nucleotide binding]
700015000520	dimerization interface [polypeptide binding]; other site
700015000521	Histidine kinase; Region: HisKA_3; pfam07730
700015000522	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700015000523	ATP binding site [chemical binding]; other site
700015000524	Mg2+ binding site [ion binding]; other site
700015000525	G-X-G motif; other site
700015000526	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
700015000527	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
700015000528	Walker A/P-loop; other site
700015000529	ATP binding site [chemical binding]; other site
700015000530	Q-loop/lid; other site
700015000531	ABC transporter signature motif; other site
700015000532	Walker B; other site
700015000533	D-loop; other site
700015000534	H-loop/switch region; other site
700015000535	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
700015000536	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
700015000537	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700015000538	Coenzyme A binding pocket [chemical binding]; other site
700015000539	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
700015000540	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
700015000541	Haemolysin-III related; Region: HlyIII; cl03831
700015000542	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
700015000543	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
700015000544	Domain of unknown function DUF21; Region: DUF21; pfam01595
700015000545	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
700015000546	Transporter associated domain; Region: CorC_HlyC; smart01091
700015000547	YtxH-like protein; Region: YtxH; pfam12732
700015000548	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
700015000549	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
700015000550	NodB motif; other site
700015000551	active site
700015000552	catalytic site [active]
700015000553	metal binding site [ion binding]; metal-binding site
700015000554	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
700015000555	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
700015000556	NodB motif; other site
700015000557	active site
700015000558	catalytic site [active]
700015000559	metal binding site [ion binding]; metal-binding site
700015000560	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
700015000561	MgtE intracellular N domain; Region: MgtE_N; smart00924
700015000562	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
700015000563	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
700015000564	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700015000565	S-adenosylmethionine binding site [chemical binding]; other site
700015000566	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
700015000567	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
700015000568	glycerol kinase; Provisional; Region: glpK; PRK00047
700015000569	N- and C-terminal domain interface [polypeptide binding]; other site
700015000570	active site
700015000571	MgATP binding site [chemical binding]; other site
700015000572	catalytic site [active]
700015000573	metal binding site [ion binding]; metal-binding site
700015000574	glycerol binding site [chemical binding]; other site
700015000575	homotetramer interface [polypeptide binding]; other site
700015000576	homodimer interface [polypeptide binding]; other site
700015000577	FBP binding site [chemical binding]; other site
700015000578	protein IIAGlc interface [polypeptide binding]; other site
700015000579	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
700015000580	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700015000581	active site
700015000582	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
700015000583	ATP synthase subunit C; Region: ATP-synt_C; cl00466
700015000584	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
700015000585	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
700015000586	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
700015000587	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
700015000588	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
700015000589	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
700015000590	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
700015000591	beta subunit interaction interface [polypeptide binding]; other site
700015000592	Walker A motif; other site
700015000593	ATP binding site [chemical binding]; other site
700015000594	Walker B motif; other site
700015000595	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
700015000596	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
700015000597	core domain interface [polypeptide binding]; other site
700015000598	delta subunit interface [polypeptide binding]; other site
700015000599	epsilon subunit interface [polypeptide binding]; other site
700015000600	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
700015000601	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
700015000602	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
700015000603	alpha subunit interaction interface [polypeptide binding]; other site
700015000604	Walker A motif; other site
700015000605	ATP binding site [chemical binding]; other site
700015000606	Walker B motif; other site
700015000607	inhibitor binding site; inhibition site
700015000608	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
700015000609	ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216
700015000610	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
700015000611	gamma subunit interface [polypeptide binding]; other site
700015000612	epsilon subunit interface [polypeptide binding]; other site
700015000613	LBP interface [polypeptide binding]; other site
700015000614	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
700015000615	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
700015000616	hinge; other site
700015000617	active site
700015000618	peptidase T; Region: peptidase-T; TIGR01882
700015000619	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
700015000620	metal binding site [ion binding]; metal-binding site
700015000621	dimer interface [polypeptide binding]; other site
700015000622	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
700015000623	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
700015000624	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
700015000625	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
700015000626	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
700015000627	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
700015000628	active site
700015000629	substrate binding site [chemical binding]; other site
700015000630	metal binding site [ion binding]; metal-binding site
700015000631	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
700015000632	Uncharacterized conserved protein [Function unknown]; Region: COG0062
700015000633	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
700015000634	putative substrate binding site [chemical binding]; other site
700015000635	putative ATP binding site [chemical binding]; other site
700015000636	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
700015000637	alanine racemase; Reviewed; Region: alr; PRK00053
700015000638	active site
700015000639	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
700015000640	dimer interface [polypeptide binding]; other site
700015000641	substrate binding site [chemical binding]; other site
700015000642	catalytic residues [active]
700015000643	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
700015000644	Fe-S cluster binding site [ion binding]; other site
700015000645	active site
700015000646	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
700015000647	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
700015000648	Glycoprotease family; Region: Peptidase_M22; pfam00814
700015000649	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700015000650	Coenzyme A binding pocket [chemical binding]; other site
700015000651	UGMP family protein; Validated; Region: PRK09604
700015000652	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
700015000653	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
700015000654	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
700015000655	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
700015000656	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
700015000657	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
700015000658	substrate binding pocket [chemical binding]; other site
700015000659	chain length determination region; other site
700015000660	substrate-Mg2+ binding site; other site
700015000661	catalytic residues [active]
700015000662	aspartate-rich region 1; other site
700015000663	active site lid residues [active]
700015000664	aspartate-rich region 2; other site
700015000665	UDP-glucose 4-epimerase; Region: PLN02240
700015000666	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
700015000667	NAD binding site [chemical binding]; other site
700015000668	homodimer interface [polypeptide binding]; other site
700015000669	active site
700015000670	substrate binding site [chemical binding]; other site
700015000671	Uncharacterized conserved protein [Function unknown]; Region: COG3334
700015000672	NlpC/P60 family; Region: NLPC_P60; cl17555
700015000673	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
700015000674	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
700015000675	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
700015000676	Walker A/P-loop; other site
700015000677	ATP binding site [chemical binding]; other site
700015000678	Q-loop/lid; other site
700015000679	ABC transporter signature motif; other site
700015000680	Walker B; other site
700015000681	D-loop; other site
700015000682	H-loop/switch region; other site
700015000683	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
700015000684	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
700015000685	Walker A/P-loop; other site
700015000686	ATP binding site [chemical binding]; other site
700015000687	Q-loop/lid; other site
700015000688	ABC transporter signature motif; other site
700015000689	Walker B; other site
700015000690	D-loop; other site
700015000691	H-loop/switch region; other site
700015000692	Predicted membrane protein [Function unknown]; Region: COG3601
700015000693	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
700015000694	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
700015000695	FAD binding domain; Region: FAD_binding_4; pfam01565
700015000696	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
700015000697	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
700015000698	AIR carboxylase; Region: AIRC; smart01001
700015000699	Protein of unknown function DUF111; Region: DUF111; pfam01969
700015000700	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
700015000701	domain interaction interfaces [polypeptide binding]; other site
700015000702	Cna protein B-type domain; Region: Cna_B; pfam05738
700015000703	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
700015000704	active site
700015000705	metal binding site [ion binding]; metal-binding site
700015000706	homotetramer interface [polypeptide binding]; other site
700015000707	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
700015000708	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
700015000709	homodimer interface [polypeptide binding]; other site
700015000710	metal binding site [ion binding]; metal-binding site
700015000711	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
700015000712	homodimer interface [polypeptide binding]; other site
700015000713	active site
700015000714	putative chemical substrate binding site [chemical binding]; other site
700015000715	metal binding site [ion binding]; metal-binding site
700015000716	enolase; Provisional; Region: eno; PRK00077
700015000717	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
700015000718	dimer interface [polypeptide binding]; other site
700015000719	metal binding site [ion binding]; metal-binding site
700015000720	substrate binding pocket [chemical binding]; other site
700015000721	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
700015000722	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700015000723	non-specific DNA binding site [nucleotide binding]; other site
700015000724	salt bridge; other site
700015000725	sequence-specific DNA binding site [nucleotide binding]; other site
700015000726	Septum formation initiator; Region: DivIC; cl17659
700015000727	exopolyphosphatase; Region: exo_poly_only; TIGR03706
700015000728	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
700015000729	nucleotide binding site [chemical binding]; other site
700015000730	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
700015000731	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
700015000732	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
700015000733	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
700015000734	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
700015000735	FeS/SAM binding site; other site
700015000736	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
700015000737	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
700015000738	dimer interface [polypeptide binding]; other site
700015000739	active site
700015000740	glycine loop; other site
700015000741	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
700015000742	active site
700015000743	intersubunit interactions; other site
700015000744	catalytic residue [active]
700015000745	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
700015000746	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
700015000747	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
700015000748	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
700015000749	active pocket/dimerization site; other site
700015000750	active site
700015000751	phosphorylation site [posttranslational modification]
700015000752	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
700015000753	active site
700015000754	phosphorylation site [posttranslational modification]
700015000755	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700015000756	non-specific DNA binding site [nucleotide binding]; other site
700015000757	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
700015000758	salt bridge; other site
700015000759	sequence-specific DNA binding site [nucleotide binding]; other site
700015000760	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
700015000761	Catalytic site [active]
700015000762	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
700015000763	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
700015000764	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
700015000765	Ligand binding site; other site
700015000766	Putative Catalytic site; other site
700015000767	DXD motif; other site
700015000768	conserved hypothetical integral membrane protein; Region: TIGR03766
700015000769	Bifunctional nuclease; Region: DNase-RNase; pfam02577
700015000770	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
700015000771	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
700015000772	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
700015000773	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
700015000774	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
700015000775	active site
700015000776	P-loop; other site
700015000777	phosphorylation site [posttranslational modification]
700015000778	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
700015000779	active site
700015000780	phosphorylation site [posttranslational modification]
700015000781	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
700015000782	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
700015000783	putative substrate binding site [chemical binding]; other site
700015000784	putative ATP binding site [chemical binding]; other site
700015000785	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
700015000786	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
700015000787	putative NAD(P) binding site [chemical binding]; other site
700015000788	catalytic Zn binding site [ion binding]; other site
700015000789	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
700015000790	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
700015000791	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
700015000792	seryl-tRNA synthetase; Provisional; Region: PRK05431
700015000793	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
700015000794	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
700015000795	dimer interface [polypeptide binding]; other site
700015000796	active site
700015000797	motif 1; other site
700015000798	motif 2; other site
700015000799	motif 3; other site
700015000800	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
700015000801	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015000802	putative substrate translocation pore; other site
700015000803	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700015000804	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
700015000805	active site
700015000806	catalytic tetrad [active]
700015000807	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315
700015000808	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
700015000809	TPP-binding site; other site
700015000810	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
700015000811	PYR/PP interface [polypeptide binding]; other site
700015000812	dimer interface [polypeptide binding]; other site
700015000813	TPP binding site [chemical binding]; other site
700015000814	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
700015000815	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
700015000816	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
700015000817	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700015000818	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700015000819	dimer interface [polypeptide binding]; other site
700015000820	phosphorylation site [posttranslational modification]
700015000821	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700015000822	ATP binding site [chemical binding]; other site
700015000823	Mg2+ binding site [ion binding]; other site
700015000824	G-X-G motif; other site
700015000825	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
700015000826	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
700015000827	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015000828	Walker A/P-loop; other site
700015000829	ATP binding site [chemical binding]; other site
700015000830	Q-loop/lid; other site
700015000831	ABC transporter signature motif; other site
700015000832	Walker B; other site
700015000833	D-loop; other site
700015000834	H-loop/switch region; other site
700015000835	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700015000836	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700015000837	active site
700015000838	phosphorylation site [posttranslational modification]
700015000839	intermolecular recognition site; other site
700015000840	dimerization interface [polypeptide binding]; other site
700015000841	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700015000842	DNA binding site [nucleotide binding]
700015000843	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
700015000844	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
700015000845	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700015000846	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700015000847	H+ Antiporter protein; Region: 2A0121; TIGR00900
700015000848	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700015000849	FtsX-like permease family; Region: FtsX; pfam02687
700015000850	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
700015000851	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
700015000852	Walker A/P-loop; other site
700015000853	ATP binding site [chemical binding]; other site
700015000854	Q-loop/lid; other site
700015000855	ABC transporter signature motif; other site
700015000856	Walker B; other site
700015000857	D-loop; other site
700015000858	H-loop/switch region; other site
700015000859	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
700015000860	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
700015000861	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
700015000862	active site
700015000863	motif I; other site
700015000864	motif II; other site
700015000865	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700015000866	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
700015000867	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
700015000868	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
700015000869	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
700015000870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
700015000871	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
700015000872	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
700015000873	NifU-like domain; Region: NifU; pfam01106
700015000874	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
700015000875	trimer interface [polypeptide binding]; other site
700015000876	active site
700015000877	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
700015000878	hypothetical protein; Validated; Region: PRK00110
700015000879	Small integral membrane protein (DUF2273); Region: DUF2273; cl11575
700015000880	Asp23 family; Region: Asp23; pfam03780
700015000881	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
700015000882	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
700015000883	Walker A/P-loop; other site
700015000884	ATP binding site [chemical binding]; other site
700015000885	Q-loop/lid; other site
700015000886	ABC transporter signature motif; other site
700015000887	Walker B; other site
700015000888	D-loop; other site
700015000889	H-loop/switch region; other site
700015000890	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
700015000891	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
700015000892	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
700015000893	Uncharacterized conserved protein [Function unknown]; Region: COG1284
700015000894	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
700015000895	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
700015000896	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
700015000897	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
700015000898	oligomerisation interface [polypeptide binding]; other site
700015000899	mobile loop; other site
700015000900	roof hairpin; other site
700015000901	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
700015000902	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
700015000903	ring oligomerisation interface [polypeptide binding]; other site
700015000904	ATP/Mg binding site [chemical binding]; other site
700015000905	stacking interactions; other site
700015000906	hinge regions; other site
700015000907	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
700015000908	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
700015000909	GTP-binding protein YchF; Reviewed; Region: PRK09601
700015000910	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
700015000911	G1 box; other site
700015000912	GTP/Mg2+ binding site [chemical binding]; other site
700015000913	G2 box; other site
700015000914	Switch I region; other site
700015000915	G3 box; other site
700015000916	Switch II region; other site
700015000917	G4 box; other site
700015000918	G5 box; other site
700015000919	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
700015000920	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
700015000921	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
700015000922	active site
700015000923	homodimer interface [polypeptide binding]; other site
700015000924	GMP synthase; Reviewed; Region: guaA; PRK00074
700015000925	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
700015000926	AMP/PPi binding site [chemical binding]; other site
700015000927	candidate oxyanion hole; other site
700015000928	catalytic triad [active]
700015000929	potential glutamine specificity residues [chemical binding]; other site
700015000930	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
700015000931	ATP Binding subdomain [chemical binding]; other site
700015000932	Ligand Binding sites [chemical binding]; other site
700015000933	Dimerization subdomain; other site
700015000934	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
700015000935	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
700015000936	YheO-like PAS domain; Region: PAS_6; pfam08348
700015000937	HTH domain; Region: HTH_22; pfam13309
700015000938	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
700015000939	homotrimer interaction site [polypeptide binding]; other site
700015000940	putative active site [active]
700015000941	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
700015000942	amino acid transporter; Region: 2A0306; TIGR00909
700015000943	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
700015000944	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
700015000945	catalytic triad [active]
700015000946	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
700015000947	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
700015000948	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700015000949	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
700015000950	Walker A/P-loop; other site
700015000951	ATP binding site [chemical binding]; other site
700015000952	Q-loop/lid; other site
700015000953	ABC transporter signature motif; other site
700015000954	Walker B; other site
700015000955	D-loop; other site
700015000956	H-loop/switch region; other site
700015000957	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
700015000958	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
700015000959	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
700015000960	Walker A/P-loop; other site
700015000961	ATP binding site [chemical binding]; other site
700015000962	Q-loop/lid; other site
700015000963	ABC transporter signature motif; other site
700015000964	Walker B; other site
700015000965	D-loop; other site
700015000966	H-loop/switch region; other site
700015000967	Predicted transcriptional regulators [Transcription]; Region: COG1725
700015000968	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700015000969	DNA-binding site [nucleotide binding]; DNA binding site
700015000970	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700015000971	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
700015000972	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
700015000973	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
700015000974	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700015000975	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700015000976	non-specific DNA binding site [nucleotide binding]; other site
700015000977	salt bridge; other site
700015000978	sequence-specific DNA binding site [nucleotide binding]; other site
700015000979	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
700015000980	AAA domain; Region: AAA_14; pfam13173
700015000981	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
700015000982	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
700015000983	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
700015000984	active site
700015000985	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
700015000986	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
700015000987	sugar binding site [chemical binding]; other site
700015000988	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
700015000989	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
700015000990	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
700015000991	MFS/sugar transport protein; Region: MFS_2; pfam13347
700015000992	beta-D-glucuronidase; Provisional; Region: PRK10150
700015000993	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700015000994	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
700015000995	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
700015000996	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
700015000997	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
700015000998	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700015000999	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700015001000	Transcriptional regulators [Transcription]; Region: GntR; COG1802
700015001001	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700015001002	DNA-binding site [nucleotide binding]; DNA binding site
700015001003	FCD domain; Region: FCD; pfam07729
700015001004	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700015001005	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700015001006	non-specific DNA binding site [nucleotide binding]; other site
700015001007	salt bridge; other site
700015001008	sequence-specific DNA binding site [nucleotide binding]; other site
700015001009	pyruvate kinase; Provisional; Region: PRK05826
700015001010	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
700015001011	domain interfaces; other site
700015001012	active site
700015001013	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
700015001014	active site
700015001015	galactoside permease; Reviewed; Region: lacY; PRK09528
700015001016	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015001017	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700015001018	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700015001019	DNA binding site [nucleotide binding]
700015001020	domain linker motif; other site
700015001021	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
700015001022	putative dimerization interface [polypeptide binding]; other site
700015001023	putative ligand binding site [chemical binding]; other site
700015001024	Propionate catabolism activator; Region: PrpR_N; pfam06506
700015001025	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
700015001026	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
700015001027	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
700015001028	Protein of unknown function, DUF1537; Region: DUF1537; cl01345
700015001029	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
700015001030	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
700015001031	putative active site [active]
700015001032	metal binding site [ion binding]; metal-binding site
700015001033	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
700015001034	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
700015001035	inhibitor site; inhibition site
700015001036	active site
700015001037	dimer interface [polypeptide binding]; other site
700015001038	catalytic residue [active]
700015001039	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
700015001040	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
700015001041	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
700015001042	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
700015001043	ligand binding site [chemical binding]; other site
700015001044	NAD binding site [chemical binding]; other site
700015001045	dimerization interface [polypeptide binding]; other site
700015001046	catalytic site [active]
700015001047	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015001048	D-galactonate transporter; Region: 2A0114; TIGR00893
700015001049	putative substrate translocation pore; other site
700015001050	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
700015001051	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
700015001052	Cna protein B-type domain; Region: Cna_B; pfam05738
700015001053	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
700015001054	golgi membrane calcium-translocating P-type ATPase; Region: ATPase-IIA2_Ca; TIGR01522
700015001055	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
700015001056	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
700015001057	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
700015001058	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
700015001059	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
700015001060	ribosome small subunit-dependent GTPase A; Region: TIGR00157
700015001061	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
700015001062	GTPase/Zn-binding domain interface [polypeptide binding]; other site
700015001063	GTP/Mg2+ binding site [chemical binding]; other site
700015001064	G4 box; other site
700015001065	G5 box; other site
700015001066	G1 box; other site
700015001067	Switch I region; other site
700015001068	G2 box; other site
700015001069	G3 box; other site
700015001070	Switch II region; other site
700015001071	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
700015001072	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
700015001073	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
700015001074	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
700015001075	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
700015001076	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
700015001077	ATP binding site [chemical binding]; other site
700015001078	Walker A motif; other site
700015001079	hexamer interface [polypeptide binding]; other site
700015001080	Walker B motif; other site
700015001081	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
700015001082	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
700015001083	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
700015001084	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700015001085	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700015001086	DNA binding site [nucleotide binding]
700015001087	domain linker motif; other site
700015001088	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
700015001089	dimerization interface [polypeptide binding]; other site
700015001090	ligand binding site [chemical binding]; other site
700015001091	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
700015001092	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
700015001093	active site turn [active]
700015001094	phosphorylation site [posttranslational modification]
700015001095	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
700015001096	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
700015001097	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
700015001098	substrate binding [chemical binding]; other site
700015001099	active site
700015001100	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
700015001101	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
700015001102	Predicted methyltransferases [General function prediction only]; Region: COG0313
700015001103	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
700015001104	putative SAM binding site [chemical binding]; other site
700015001105	putative homodimer interface [polypeptide binding]; other site
700015001106	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
700015001107	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
700015001108	active site
700015001109	HIGH motif; other site
700015001110	KMSKS motif; other site
700015001111	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
700015001112	tRNA binding surface [nucleotide binding]; other site
700015001113	anticodon binding site; other site
700015001114	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
700015001115	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
700015001116	S-adenosylmethionine binding site [chemical binding]; other site
700015001117	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
700015001118	active site
700015001119	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
700015001120	AAA domain; Region: AAA_14; pfam13173
700015001121	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
700015001122	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
700015001123	ligand binding site [chemical binding]; other site
700015001124	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
700015001125	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
700015001126	TM-ABC transporter signature motif; other site
700015001127	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
700015001128	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
700015001129	Walker A/P-loop; other site
700015001130	ATP binding site [chemical binding]; other site
700015001131	Q-loop/lid; other site
700015001132	ABC transporter signature motif; other site
700015001133	Walker B; other site
700015001134	D-loop; other site
700015001135	H-loop/switch region; other site
700015001136	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
700015001137	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
700015001138	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
700015001139	TM-ABC transporter signature motif; other site
700015001140	L-arabinose isomerase; Provisional; Region: PRK02929
700015001141	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
700015001142	hexamer (dimer of trimers) interface [polypeptide binding]; other site
700015001143	trimer interface [polypeptide binding]; other site
700015001144	substrate binding site [chemical binding]; other site
700015001145	Mn binding site [ion binding]; other site
700015001146	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
700015001147	nucleotide binding site [chemical binding]; other site
700015001148	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
700015001149	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
700015001150	intersubunit interface [polypeptide binding]; other site
700015001151	active site
700015001152	Zn2+ binding site [ion binding]; other site
700015001153	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
700015001154	active site
700015001155	catalytic residues [active]
700015001156	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700015001157	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700015001158	DNA binding site [nucleotide binding]
700015001159	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700015001160	ligand binding site [chemical binding]; other site
700015001161	dimerization interface [polypeptide binding]; other site
700015001162	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
700015001163	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
700015001164	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
700015001165	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700015001166	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700015001167	active site
700015001168	phosphorylation site [posttranslational modification]
700015001169	intermolecular recognition site; other site
700015001170	dimerization interface [polypeptide binding]; other site
700015001171	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700015001172	DNA binding site [nucleotide binding]
700015001173	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700015001174	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700015001175	dimer interface [polypeptide binding]; other site
700015001176	phosphorylation site [posttranslational modification]
700015001177	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700015001178	ATP binding site [chemical binding]; other site
700015001179	Mg2+ binding site [ion binding]; other site
700015001180	G-X-G motif; other site
700015001181	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700015001182	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700015001183	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
700015001184	Walker A/P-loop; other site
700015001185	ATP binding site [chemical binding]; other site
700015001186	Q-loop/lid; other site
700015001187	ABC transporter signature motif; other site
700015001188	Walker B; other site
700015001189	D-loop; other site
700015001190	H-loop/switch region; other site
700015001191	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700015001192	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700015001193	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015001194	Walker A/P-loop; other site
700015001195	ATP binding site [chemical binding]; other site
700015001196	Q-loop/lid; other site
700015001197	ABC transporter signature motif; other site
700015001198	Walker B; other site
700015001199	D-loop; other site
700015001200	H-loop/switch region; other site
700015001201	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
700015001202	MarR family; Region: MarR_2; pfam12802
700015001203	galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527
700015001204	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
700015001205	active site
700015001206	substrate binding site [chemical binding]; other site
700015001207	trimer interface [polypeptide binding]; other site
700015001208	CoA binding site [chemical binding]; other site
700015001209	Isochorismatase family; Region: Isochorismatase; pfam00857
700015001210	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
700015001211	catalytic triad [active]
700015001212	conserved cis-peptide bond; other site
700015001213	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
700015001214	Helix-turn-helix domain; Region: HTH_28; pfam13518
700015001215	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
700015001216	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700015001217	Flavodoxin; Region: Flavodoxin_1; pfam00258
700015001218	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015001219	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
700015001220	Walker A/P-loop; other site
700015001221	ATP binding site [chemical binding]; other site
700015001222	Q-loop/lid; other site
700015001223	ABC transporter signature motif; other site
700015001224	Walker B; other site
700015001225	D-loop; other site
700015001226	H-loop/switch region; other site
700015001227	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700015001228	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700015001229	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
700015001230	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
700015001231	Walker A/P-loop; other site
700015001232	ATP binding site [chemical binding]; other site
700015001233	Q-loop/lid; other site
700015001234	ABC transporter signature motif; other site
700015001235	Walker B; other site
700015001236	D-loop; other site
700015001237	H-loop/switch region; other site
700015001238	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
700015001239	FtsX-like permease family; Region: FtsX; pfam02687
700015001240	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
700015001241	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700015001242	FtsX-like permease family; Region: FtsX; pfam02687
700015001243	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
700015001244	methionine sulfoxide reductase B; Provisional; Region: PRK00222
700015001245	SelR domain; Region: SelR; pfam01641
700015001246	Pirin-related protein [General function prediction only]; Region: COG1741
700015001247	Pirin; Region: Pirin; pfam02678
700015001248	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
700015001249	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
700015001250	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
700015001251	NAD binding site [chemical binding]; other site
700015001252	ligand binding site [chemical binding]; other site
700015001253	catalytic site [active]
700015001254	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
700015001255	putative active site [active]
700015001256	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700015001257	DNA binding residues [nucleotide binding]
700015001258	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
700015001259	DNA binding residues [nucleotide binding]
700015001260	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700015001261	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
700015001262	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015001263	Walker A/P-loop; other site
700015001264	ATP binding site [chemical binding]; other site
700015001265	Q-loop/lid; other site
700015001266	ABC transporter signature motif; other site
700015001267	Walker B; other site
700015001268	D-loop; other site
700015001269	H-loop/switch region; other site
700015001270	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
700015001271	FtsX-like permease family; Region: FtsX; pfam02687
700015001272	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
700015001273	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
700015001274	Walker A/P-loop; other site
700015001275	ATP binding site [chemical binding]; other site
700015001276	Q-loop/lid; other site
700015001277	ABC transporter signature motif; other site
700015001278	Walker B; other site
700015001279	D-loop; other site
700015001280	H-loop/switch region; other site
700015001281	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
700015001282	FtsX-like permease family; Region: FtsX; pfam02687
700015001283	FtsX-like permease family; Region: FtsX; pfam02687
700015001284	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
700015001285	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
700015001286	active pocket/dimerization site; other site
700015001287	active site
700015001288	phosphorylation site [posttranslational modification]
700015001289	Preprotein translocase subunit; Region: YajC; pfam02699
700015001290	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
700015001291	active site
700015001292	phosphorylation site [posttranslational modification]
700015001293	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
700015001294	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
700015001295	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
700015001296	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
700015001297	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700015001298	DNA-binding site [nucleotide binding]; DNA binding site
700015001299	UTRA domain; Region: UTRA; pfam07702
700015001300	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
700015001301	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
700015001302	dimer interface [polypeptide binding]; other site
700015001303	active site
700015001304	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
700015001305	putative active site [active]
700015001306	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
700015001307	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
700015001308	active site
700015001309	dimer interface [polypeptide binding]; other site
700015001310	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
700015001311	active site
700015001312	catalytic residues [active]
700015001313	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
700015001314	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
700015001315	putative substrate binding site [chemical binding]; other site
700015001316	putative ATP binding site [chemical binding]; other site
700015001317	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
700015001318	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
700015001319	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
700015001320	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
700015001321	active site
700015001322	phosphorylation site [posttranslational modification]
700015001323	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
700015001324	active site
700015001325	P-loop; other site
700015001326	phosphorylation site [posttranslational modification]
700015001327	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
700015001328	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
700015001329	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
700015001330	galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309
700015001331	putative NAD(P) binding site [chemical binding]; other site
700015001332	catalytic Zn binding site [ion binding]; other site
700015001333	DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411
700015001334	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
700015001335	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
700015001336	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
700015001337	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
700015001338	intersubunit interface [polypeptide binding]; other site
700015001339	active site
700015001340	zinc binding site [ion binding]; other site
700015001341	Na+ binding site [ion binding]; other site
700015001342	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
700015001343	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
700015001344	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
700015001345	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
700015001346	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044
700015001347	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
700015001348	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
700015001349	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
700015001350	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756
700015001351	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
700015001352	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
700015001353	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755
700015001354	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
700015001355	active site
700015001356	metal binding site [ion binding]; metal-binding site
700015001357	DNA topoisomerase I; Validated; Region: PRK07219
700015001358	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
700015001359	domain I; other site
700015001360	DNA binding groove [nucleotide binding]
700015001361	phosphate binding site [ion binding]; other site
700015001362	domain II; other site
700015001363	domain III; other site
700015001364	nucleotide binding site [chemical binding]; other site
700015001365	catalytic site [active]
700015001366	domain IV; other site
700015001367	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
700015001368	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
700015001369	thymidylate kinase; Validated; Region: tmk; PRK00698
700015001370	TMP-binding site; other site
700015001371	ATP-binding site [chemical binding]; other site
700015001372	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
700015001373	DNA polymerase III subunit delta'; Validated; Region: PRK08485
700015001374	PSP1 C-terminal conserved region; Region: PSP1; cl00770
700015001375	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
700015001376	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700015001377	active site
700015001378	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
700015001379	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
700015001380	substrate binding pocket [chemical binding]; other site
700015001381	membrane-bound complex binding site; other site
700015001382	hinge residues; other site
700015001383	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
700015001384	30S subunit binding site; other site
700015001385	EDD domain protein, DegV family; Region: DegV; TIGR00762
700015001386	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
700015001387	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
700015001388	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
700015001389	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
700015001390	active site
700015001391	catalytic site [active]
700015001392	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
700015001393	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
700015001394	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
700015001395	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
700015001396	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
700015001397	Soluble P-type ATPase [General function prediction only]; Region: COG4087
700015001398	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
700015001399	Uncharacterized conserved protein [Function unknown]; Region: COG1284
700015001400	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
700015001401	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
700015001402	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08415
700015001403	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
700015001404	Phosphopantetheine attachment site; Region: PP-binding; cl09936
700015001405	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
700015001406	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
700015001407	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
700015001408	catalytic residue [active]
700015001409	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
700015001410	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
700015001411	acyl-activating enzyme (AAE) consensus motif; other site
700015001412	AMP binding site [chemical binding]; other site
700015001413	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700015001414	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700015001415	dimer interface [polypeptide binding]; other site
700015001416	phosphorylation site [posttranslational modification]
700015001417	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700015001418	ATP binding site [chemical binding]; other site
700015001419	Mg2+ binding site [ion binding]; other site
700015001420	G-X-G motif; other site
700015001421	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700015001422	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700015001423	active site
700015001424	phosphorylation site [posttranslational modification]
700015001425	intermolecular recognition site; other site
700015001426	dimerization interface [polypeptide binding]; other site
700015001427	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700015001428	DNA binding site [nucleotide binding]
700015001429	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
700015001430	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
700015001431	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015001432	putative transporter; Provisional; Region: PRK10504
700015001433	putative substrate translocation pore; other site
700015001434	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015001435	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
700015001436	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
700015001437	cofactor binding site; other site
700015001438	DNA binding site [nucleotide binding]
700015001439	substrate interaction site [chemical binding]; other site
700015001440	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
700015001441	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
700015001442	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700015001443	DNA-binding site [nucleotide binding]; DNA binding site
700015001444	UTRA domain; Region: UTRA; pfam07702
700015001445	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
700015001446	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700015001447	DNA-binding site [nucleotide binding]; DNA binding site
700015001448	UTRA domain; Region: UTRA; cl17743
700015001449	PGAP1-like protein; Region: PGAP1; pfam07819
700015001450	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700015001451	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
700015001452	thiS-thiF/thiG interaction site; other site
700015001453	thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644
700015001454	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
700015001455	ATP binding site [chemical binding]; other site
700015001456	substrate interface [chemical binding]; other site
700015001457	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
700015001458	ThiS interaction site; other site
700015001459	putative active site [active]
700015001460	tetramer interface [polypeptide binding]; other site
700015001461	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
700015001462	thiamine phosphate binding site [chemical binding]; other site
700015001463	active site
700015001464	pyrophosphate binding site [ion binding]; other site
700015001465	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
700015001466	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
700015001467	Walker A/P-loop; other site
700015001468	ATP binding site [chemical binding]; other site
700015001469	Q-loop/lid; other site
700015001470	ABC transporter signature motif; other site
700015001471	Walker B; other site
700015001472	D-loop; other site
700015001473	H-loop/switch region; other site
700015001474	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
700015001475	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
700015001476	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
700015001477	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
700015001478	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
700015001479	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
700015001480	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
700015001481	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
700015001482	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
700015001483	active site
700015001484	catalytic site [active]
700015001485	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
700015001486	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
700015001487	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
700015001488	Family description; Region: DsbD_2; pfam13386
700015001489	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
700015001490	Ferritin-like domain; Region: Ferritin; pfam00210
700015001491	ferroxidase diiron center [ion binding]; other site
700015001492	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
700015001493	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
700015001494	active site
700015001495	HIGH motif; other site
700015001496	nucleotide binding site [chemical binding]; other site
700015001497	active site
700015001498	KMSKS motif; other site
700015001499	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
700015001500	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
700015001501	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
700015001502	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
700015001503	active site
700015001504	phosphorylation site [posttranslational modification]
700015001505	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
700015001506	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
700015001507	active site
700015001508	P-loop; other site
700015001509	phosphorylation site [posttranslational modification]
700015001510	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
700015001511	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
700015001512	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
700015001513	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
700015001514	AP (apurinic/apyrimidinic) site pocket; other site
700015001515	DNA interaction; other site
700015001516	Metal-binding active site; metal-binding site
700015001517	Sensory domain found in PocR; Region: PocR; pfam10114
700015001518	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
700015001519	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700015001520	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700015001521	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
700015001522	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
700015001523	dimer interface [polypeptide binding]; other site
700015001524	active site
700015001525	metal binding site [ion binding]; metal-binding site
700015001526	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
700015001527	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
700015001528	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
700015001529	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
700015001530	DAK2 domain; Region: Dak2; cl03685
700015001531	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
700015001532	putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983
700015001533	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
700015001534	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
700015001535	Cupin domain; Region: Cupin_2; cl17218
700015001536	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700015001537	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700015001538	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700015001539	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
700015001540	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
700015001541	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
700015001542	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
700015001543	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
700015001544	L-aspartate oxidase; Provisional; Region: PRK06175
700015001545	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
700015001546	PRD domain; Region: PRD; pfam00874
700015001547	PRD domain; Region: PRD; pfam00874
700015001548	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
700015001549	active site
700015001550	P-loop; other site
700015001551	phosphorylation site [posttranslational modification]
700015001552	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
700015001553	active site
700015001554	phosphorylation site [posttranslational modification]
700015001555	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
700015001556	active site
700015001557	methionine cluster; other site
700015001558	phosphorylation site [posttranslational modification]
700015001559	metal binding site [ion binding]; metal-binding site
700015001560	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
700015001561	beta-galactosidase; Region: BGL; TIGR03356
700015001562	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
700015001563	active site
700015001564	P-loop; other site
700015001565	phosphorylation site [posttranslational modification]
700015001566	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
700015001567	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
700015001568	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
700015001569	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
700015001570	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
700015001571	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
700015001572	purine monophosphate binding site [chemical binding]; other site
700015001573	dimer interface [polypeptide binding]; other site
700015001574	putative catalytic residues [active]
700015001575	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
700015001576	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
700015001577	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700015001578	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700015001579	active site
700015001580	phosphorylation site [posttranslational modification]
700015001581	intermolecular recognition site; other site
700015001582	dimerization interface [polypeptide binding]; other site
700015001583	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700015001584	DNA binding site [nucleotide binding]
700015001585	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700015001586	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700015001587	dimer interface [polypeptide binding]; other site
700015001588	phosphorylation site [posttranslational modification]
700015001589	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700015001590	ATP binding site [chemical binding]; other site
700015001591	Mg2+ binding site [ion binding]; other site
700015001592	G-X-G motif; other site
700015001593	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700015001594	Ligand Binding Site [chemical binding]; other site
700015001595	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
700015001596	phosphopentomutase; Provisional; Region: PRK05362
700015001597	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
700015001598	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
700015001599	intersubunit interface [polypeptide binding]; other site
700015001600	active site
700015001601	catalytic residue [active]
700015001602	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
700015001603	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
700015001604	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
700015001605	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
700015001606	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
700015001607	active site
700015001608	catalytic motif [active]
700015001609	Zn binding site [ion binding]; other site
700015001610	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
700015001611	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
700015001612	TM-ABC transporter signature motif; other site
700015001613	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
700015001614	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
700015001615	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
700015001616	TM-ABC transporter signature motif; other site
700015001617	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
700015001618	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
700015001619	Walker A/P-loop; other site
700015001620	ATP binding site [chemical binding]; other site
700015001621	Q-loop/lid; other site
700015001622	ABC transporter signature motif; other site
700015001623	Walker B; other site
700015001624	D-loop; other site
700015001625	H-loop/switch region; other site
700015001626	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
700015001627	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
700015001628	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
700015001629	ligand binding site [chemical binding]; other site
700015001630	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
700015001631	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
700015001632	Part of AAA domain; Region: AAA_19; pfam13245
700015001633	Family description; Region: UvrD_C_2; pfam13538
700015001634	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
700015001635	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700015001636	FeS/SAM binding site; other site
700015001637	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700015001638	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
700015001639	active site
700015001640	P-loop; other site
700015001641	phosphorylation site [posttranslational modification]
700015001642	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
700015001643	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
700015001644	nucleotide binding site [chemical binding]; other site
700015001645	Uncharacterized conserved protein [Function unknown]; Region: COG3538
700015001646	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
700015001647	alpha-mannosidase; Provisional; Region: PRK09819
700015001648	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
700015001649	active site
700015001650	metal binding site [ion binding]; metal-binding site
700015001651	catalytic site [active]
700015001652	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
700015001653	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
700015001654	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
700015001655	dihydroxyacetone kinase; Provisional; Region: PRK14479
700015001656	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
700015001657	DAK2 domain; Region: Dak2; pfam02734
700015001658	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
700015001659	active site
700015001660	phosphorylation site [posttranslational modification]
700015001661	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
700015001662	active site
700015001663	P-loop; other site
700015001664	phosphorylation site [posttranslational modification]
700015001665	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
700015001666	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
700015001667	Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235
700015001668	intersubunit interface [polypeptide binding]; other site
700015001669	active site
700015001670	Zn2+ binding site [ion binding]; other site
700015001671	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700015001672	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700015001673	DNA binding site [nucleotide binding]
700015001674	domain linker motif; other site
700015001675	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700015001676	dimerization interface [polypeptide binding]; other site
700015001677	ligand binding site [chemical binding]; other site
700015001678	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700015001679	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700015001680	DNA binding site [nucleotide binding]
700015001681	domain linker motif; other site
700015001682	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700015001683	dimerization interface [polypeptide binding]; other site
700015001684	ligand binding site [chemical binding]; other site
700015001685	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
700015001686	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
700015001687	phosphate binding site [ion binding]; other site
700015001688	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
700015001689	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700015001690	NAD(P) binding site [chemical binding]; other site
700015001691	active site
700015001692	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
700015001693	L-aspartate oxidase; Provisional; Region: PRK06175
700015001694	Predicted membrane protein [Function unknown]; Region: COG2364
700015001695	hypothetical protein; Validated; Region: PRK06201
700015001696	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
700015001697	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
700015001698	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
700015001699	aspartate aminotransferase; Provisional; Region: PRK05764
700015001700	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700015001701	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700015001702	homodimer interface [polypeptide binding]; other site
700015001703	catalytic residue [active]
700015001704	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
700015001705	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
700015001706	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
700015001707	putative active site [active]
700015001708	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015001709	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
700015001710	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
700015001711	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
700015001712	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
700015001713	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
700015001714	putative active site [active]
700015001715	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
700015001716	N- and C-terminal domain interface [polypeptide binding]; other site
700015001717	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
700015001718	active site
700015001719	putative catalytic site [active]
700015001720	metal binding site [ion binding]; metal-binding site
700015001721	ATP binding site [chemical binding]; other site
700015001722	carbohydrate binding site [chemical binding]; other site
700015001723	L-rhamnose isomerase; Provisional; Region: PRK01076
700015001724	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
700015001725	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
700015001726	intersubunit interface [polypeptide binding]; other site
700015001727	active site
700015001728	Zn2+ binding site [ion binding]; other site
700015001729	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
700015001730	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
700015001731	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
700015001732	mannonate dehydratase; Provisional; Region: PRK03906
700015001733	mannonate dehydratase; Region: uxuA; TIGR00695
700015001734	Glucuronate isomerase; Region: UxaC; pfam02614
700015001735	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
700015001736	Transcriptional regulators [Transcription]; Region: GntR; COG1802
700015001737	DNA-binding site [nucleotide binding]; DNA binding site
700015001738	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
700015001739	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
700015001740	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
700015001741	Glycosyl hydrolase family 67 middle domain; Region: Glyco_hydro_67M; pfam07488
700015001742	Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477
700015001743	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
700015001744	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
700015001745	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
700015001746	inhibitor binding site; inhibition site
700015001747	active site
700015001748	Domain of unknown function (DUF303); Region: DUF303; pfam03629
700015001749	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
700015001750	Domain of unknown function (DUF303); Region: DUF303; pfam03629
700015001751	Predicted kinase [General function prediction only]; Region: COG4857; cl17281
700015001752	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
700015001753	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
700015001754	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
700015001755	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
700015001756	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
700015001757	active site
700015001758	P-loop; other site
700015001759	phosphorylation site [posttranslational modification]
700015001760	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
700015001761	active site
700015001762	phosphorylation site [posttranslational modification]
700015001763	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
700015001764	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
700015001765	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
700015001766	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
700015001767	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
700015001768	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
700015001769	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
700015001770	substrate binding site [chemical binding]; other site
700015001771	hexamer interface [polypeptide binding]; other site
700015001772	metal binding site [ion binding]; metal-binding site
700015001773	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
700015001774	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
700015001775	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
700015001776	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
700015001777	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
700015001778	Malic enzyme, N-terminal domain; Region: malic; pfam00390
700015001779	Malic enzyme, NAD binding domain; Region: Malic_M; smart00919
700015001780	NAD(P) binding pocket [chemical binding]; other site
700015001781	Membrane transport protein; Region: Mem_trans; pfam03547
700015001782	[citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124
700015001783	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700015001784	active site
700015001785	nucleotide binding site [chemical binding]; other site
700015001786	HIGH motif; other site
700015001787	KMSKS motif; other site
700015001788	citrate lyase subunit gamma; Provisional; Region: PRK13253
700015001789	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
700015001790	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
700015001791	Coenzyme A transferase; Region: CoA_trans; cl17247
700015001792	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498
700015001793	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
700015001794	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700015001795	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700015001796	DNA binding site [nucleotide binding]
700015001797	domain linker motif; other site
700015001798	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
700015001799	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
700015001800	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
700015001801	substrate binding site [chemical binding]; other site
700015001802	ATP binding site [chemical binding]; other site
700015001803	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
700015001804	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
700015001805	active site
700015001806	intersubunit interface [polypeptide binding]; other site
700015001807	catalytic residue [active]
700015001808	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
700015001809	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
700015001810	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
700015001811	putative active site [active]
700015001812	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cl00234
700015001813	active site
700015001814	catalytic residues [active]
700015001815	metal binding site [ion binding]; metal-binding site
700015001816	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700015001817	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
700015001818	active site
700015001819	motif I; other site
700015001820	motif II; other site
700015001821	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
700015001822	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
700015001823	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
700015001824	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
700015001825	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
700015001826	substrate binding [chemical binding]; other site
700015001827	active site
700015001828	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
700015001829	galactoside permease; Reviewed; Region: lacY; PRK09528
700015001830	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015001831	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
700015001832	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700015001833	ATP binding site [chemical binding]; other site
700015001834	putative Mg++ binding site [ion binding]; other site
700015001835	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700015001836	nucleotide binding region [chemical binding]; other site
700015001837	ATP-binding site [chemical binding]; other site
700015001838	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
700015001839	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293
700015001840	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
700015001841	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
700015001842	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700015001843	S-adenosylmethionine binding site [chemical binding]; other site
700015001844	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
700015001845	S-adenosylmethionine binding site [chemical binding]; other site
700015001846	Radical SAM superfamily; Region: Radical_SAM; pfam04055
700015001847	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700015001848	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700015001849	Coenzyme A binding pocket [chemical binding]; other site
700015001850	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700015001851	S-adenosylmethionine binding site [chemical binding]; other site
700015001852	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700015001853	ATP binding site [chemical binding]; other site
700015001854	putative Mg++ binding site [ion binding]; other site
700015001855	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700015001856	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
700015001857	nucleotide binding region [chemical binding]; other site
700015001858	ATP-binding site [chemical binding]; other site
700015001859	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
700015001860	AAA ATPase domain; Region: AAA_16; pfam13191
700015001861	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
700015001862	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
700015001863	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
700015001864	dimerization interface [polypeptide binding]; other site
700015001865	ATP binding site [chemical binding]; other site
700015001866	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
700015001867	dimerization interface [polypeptide binding]; other site
700015001868	ATP binding site [chemical binding]; other site
700015001869	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
700015001870	putative active site [active]
700015001871	catalytic triad [active]
700015001872	Sulfatase; Region: Sulfatase; cl17466
700015001873	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
700015001874	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
700015001875	putative ligand binding site [chemical binding]; other site
700015001876	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
700015001877	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
700015001878	TM-ABC transporter signature motif; other site
700015001879	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
700015001880	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
700015001881	TM-ABC transporter signature motif; other site
700015001882	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
700015001883	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
700015001884	Walker A/P-loop; other site
700015001885	ATP binding site [chemical binding]; other site
700015001886	Q-loop/lid; other site
700015001887	ABC transporter signature motif; other site
700015001888	Walker B; other site
700015001889	D-loop; other site
700015001890	H-loop/switch region; other site
700015001891	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
700015001892	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
700015001893	Walker A/P-loop; other site
700015001894	ATP binding site [chemical binding]; other site
700015001895	Q-loop/lid; other site
700015001896	ABC transporter signature motif; other site
700015001897	Walker B; other site
700015001898	D-loop; other site
700015001899	H-loop/switch region; other site
700015001900	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
700015001901	DHH family; Region: DHH; pfam01368
700015001902	DHHA1 domain; Region: DHHA1; pfam02272
700015001903	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
700015001904	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700015001905	ATP binding site [chemical binding]; other site
700015001906	putative Mg++ binding site [ion binding]; other site
700015001907	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700015001908	nucleotide binding region [chemical binding]; other site
700015001909	ATP-binding site [chemical binding]; other site
700015001910	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
700015001911	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
700015001912	Zn2+ binding site [ion binding]; other site
700015001913	Mg2+ binding site [ion binding]; other site
700015001914	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
700015001915	synthetase active site [active]
700015001916	NTP binding site [chemical binding]; other site
700015001917	metal binding site [ion binding]; metal-binding site
700015001918	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
700015001919	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
700015001920	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
700015001921	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
700015001922	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
700015001923	intersubunit interface [polypeptide binding]; other site
700015001924	active site
700015001925	zinc binding site [ion binding]; other site
700015001926	Na+ binding site [ion binding]; other site
700015001927	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
700015001928	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
700015001929	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
700015001930	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
700015001931	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
700015001932	23S rRNA binding site [nucleotide binding]; other site
700015001933	L21 binding site [polypeptide binding]; other site
700015001934	L13 binding site [polypeptide binding]; other site
700015001935	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
700015001936	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
700015001937	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
700015001938	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
700015001939	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
700015001940	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
700015001941	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
700015001942	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
700015001943	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
700015001944	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
700015001945	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
700015001946	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
700015001947	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
700015001948	dephospho-CoA kinase; Region: TIGR00152
700015001949	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
700015001950	ATP-binding [chemical binding]; other site
700015001951	CoA-binding site [chemical binding]; other site
700015001952	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
700015001953	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
700015001954	N-acetyl-D-glucosamine binding site [chemical binding]; other site
700015001955	catalytic residue [active]
700015001956	excinuclease ABC subunit B; Provisional; Region: PRK05298
700015001957	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700015001958	ATP binding site [chemical binding]; other site
700015001959	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700015001960	nucleotide binding region [chemical binding]; other site
700015001961	ATP-binding site [chemical binding]; other site
700015001962	Ultra-violet resistance protein B; Region: UvrB; pfam12344
700015001963	UvrB/uvrC motif; Region: UVR; pfam02151
700015001964	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
700015001965	DEAD-like helicases superfamily; Region: DEXDc; smart00487
700015001966	ATP binding site [chemical binding]; other site
700015001967	Mg++ binding site [ion binding]; other site
700015001968	motif III; other site
700015001969	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700015001970	nucleotide binding region [chemical binding]; other site
700015001971	ATP-binding site [chemical binding]; other site
700015001972	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
700015001973	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
700015001974	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
700015001975	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
700015001976	Ligand Binding Site [chemical binding]; other site
700015001977	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
700015001978	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
700015001979	dimer interface [polypeptide binding]; other site
700015001980	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700015001981	catalytic residue [active]
700015001982	Transcriptional regulator; Region: Rrf2; cl17282
700015001983	Rrf2 family protein; Region: rrf2_super; TIGR00738
700015001984	Membrane protein of unknown function; Region: DUF360; pfam04020
700015001985	Trp repressor protein; Region: Trp_repressor; cl17266
700015001986	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
700015001987	Part of AAA domain; Region: AAA_19; pfam13245
700015001988	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
700015001989	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
700015001990	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
700015001991	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
700015001992	ABC transporter; Region: ABC_tran_2; pfam12848
700015001993	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
700015001994	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700015001995	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
700015001996	active site
700015001997	motif I; other site
700015001998	motif II; other site
700015001999	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700015002000	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
700015002001	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
700015002002	Soluble P-type ATPase [General function prediction only]; Region: COG4087
700015002003	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
700015002004	metal-binding site [ion binding]
700015002005	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700015002006	dimerization interface [polypeptide binding]; other site
700015002007	putative DNA binding site [nucleotide binding]; other site
700015002008	putative Zn2+ binding site [ion binding]; other site
700015002009	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
700015002010	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
700015002011	active site
700015002012	catalytic site [active]
700015002013	substrate binding site [chemical binding]; other site
700015002014	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
700015002015	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
700015002016	SEC-C motif; Region: SEC-C; pfam02810
700015002017	peptide chain release factor 2; Validated; Region: prfB; PRK00578
700015002018	PCRF domain; Region: PCRF; pfam03462
700015002019	RF-1 domain; Region: RF-1; pfam00472
700015002020	Uncharacterized conserved protein [Function unknown]; Region: COG1284
700015002021	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
700015002022	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
700015002023	transketolase; Reviewed; Region: PRK05899
700015002024	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
700015002025	TPP-binding site [chemical binding]; other site
700015002026	dimer interface [polypeptide binding]; other site
700015002027	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
700015002028	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
700015002029	PYR/PP interface [polypeptide binding]; other site
700015002030	dimer interface [polypeptide binding]; other site
700015002031	TPP binding site [chemical binding]; other site
700015002032	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
700015002033	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
700015002034	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015002035	Walker A/P-loop; other site
700015002036	ATP binding site [chemical binding]; other site
700015002037	Q-loop/lid; other site
700015002038	ABC transporter signature motif; other site
700015002039	Walker B; other site
700015002040	D-loop; other site
700015002041	H-loop/switch region; other site
700015002042	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
700015002043	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
700015002044	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
700015002045	TPR motif; other site
700015002046	binding surface
700015002047	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
700015002048	SmpB-tmRNA interface; other site
700015002049	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
700015002050	Rubredoxin [Energy production and conversion]; Region: COG1773
700015002051	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
700015002052	iron binding site [ion binding]; other site
700015002053	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
700015002054	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700015002055	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
700015002056	active site
700015002057	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
700015002058	metal-binding site [ion binding]
700015002059	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
700015002060	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
700015002061	metal-binding site [ion binding]
700015002062	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
700015002063	Soluble P-type ATPase [General function prediction only]; Region: COG4087
700015002064	Predicted flavoprotein [General function prediction only]; Region: COG0431
700015002065	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
700015002066	endonuclease IV; Provisional; Region: PRK01060
700015002067	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
700015002068	AP (apurinic/apyrimidinic) site pocket; other site
700015002069	DNA interaction; other site
700015002070	Metal-binding active site; metal-binding site
700015002071	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
700015002072	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
700015002073	active site
700015002074	NAD binding site [chemical binding]; other site
700015002075	metal binding site [ion binding]; metal-binding site
700015002076	Uncharacterized conserved protein [Function unknown]; Region: COG4198
700015002077	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
700015002078	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
700015002079	active site
700015002080	metal binding site [ion binding]; metal-binding site
700015002081	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
700015002082	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
700015002083	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
700015002084	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
700015002085	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
700015002086	active site
700015002087	substrate-binding site [chemical binding]; other site
700015002088	metal-binding site [ion binding]
700015002089	ATP binding site [chemical binding]; other site
700015002090	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
700015002091	catalytic core [active]
700015002092	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
700015002093	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
700015002094	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
700015002095	DNA binding site [nucleotide binding]
700015002096	active site
700015002097	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
700015002098	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
700015002099	Mg++ binding site [ion binding]; other site
700015002100	putative catalytic motif [active]
700015002101	substrate binding site [chemical binding]; other site
700015002102	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
700015002103	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
700015002104	active site
700015002105	HIGH motif; other site
700015002106	dimer interface [polypeptide binding]; other site
700015002107	KMSKS motif; other site
700015002108	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
700015002109	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700015002110	active site
700015002111	motif I; other site
700015002112	motif II; other site
700015002113	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700015002114	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700015002115	Radical SAM superfamily; Region: Radical_SAM; pfam04055
700015002116	FeS/SAM binding site; other site
700015002117	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
700015002118	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
700015002119	active site
700015002120	gamma-glutamyl kinase; Provisional; Region: PRK05429
700015002121	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
700015002122	nucleotide binding site [chemical binding]; other site
700015002123	homotetrameric interface [polypeptide binding]; other site
700015002124	putative phosphate binding site [ion binding]; other site
700015002125	putative allosteric binding site; other site
700015002126	PUA domain; Region: PUA; pfam01472
700015002127	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
700015002128	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
700015002129	putative catalytic cysteine [active]
700015002130	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
700015002131	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
700015002132	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
700015002133	PRD domain; Region: PRD; pfam00874
700015002134	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
700015002135	active site
700015002136	P-loop; other site
700015002137	phosphorylation site [posttranslational modification]
700015002138	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
700015002139	active site
700015002140	phosphorylation site [posttranslational modification]
700015002141	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
700015002142	active site
700015002143	phosphorylation site [posttranslational modification]
700015002144	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
700015002145	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
700015002146	active site
700015002147	P-loop; other site
700015002148	phosphorylation site [posttranslational modification]
700015002149	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
700015002150	active site
700015002151	intersubunit interactions; other site
700015002152	catalytic residue [active]
700015002153	Transcriptional regulator [Transcription]; Region: LytR; COG1316
700015002154	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
700015002155	ATP cone domain; Region: ATP-cone; pfam03477
700015002156	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
700015002157	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
700015002158	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700015002159	FeS/SAM binding site; other site
700015002160	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
700015002161	GTP cyclohydrolase I; Provisional; Region: PLN03044
700015002162	active site
700015002163	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
700015002164	homooctamer interface [polypeptide binding]; other site
700015002165	active site
700015002166	Protein of unknown function DUF45; Region: DUF45; pfam01863
700015002167	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
700015002168	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
700015002169	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
700015002170	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700015002171	active site
700015002172	motif I; other site
700015002173	motif II; other site
700015002174	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
700015002175	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
700015002176	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
700015002177	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
700015002178	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
700015002179	putative active site [active]
700015002180	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
700015002181	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
700015002182	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
700015002183	active site
700015002184	phosphorylation site [posttranslational modification]
700015002185	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
700015002186	active pocket/dimerization site; other site
700015002187	active site
700015002188	phosphorylation site [posttranslational modification]
700015002189	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172
700015002190	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
700015002191	putative ligand binding site [chemical binding]; other site
700015002192	putative NAD binding site [chemical binding]; other site
700015002193	catalytic site [active]
700015002194	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
700015002195	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
700015002196	active site
700015002197	intersubunit interface [polypeptide binding]; other site
700015002198	catalytic residue [active]
700015002199	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
700015002200	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
700015002201	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700015002202	motif II; other site
700015002203	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
700015002204	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700015002205	active site
700015002206	motif I; other site
700015002207	motif II; other site
700015002208	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700015002209	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
700015002210	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
700015002211	YolD-like protein; Region: YolD; pfam08863
700015002212	DNA polymerase IV; Reviewed; Region: PRK03103
700015002213	Y-family of DNA polymerases; Region: PolY; cl12025
700015002214	active site
700015002215	DNA binding site [nucleotide binding]
700015002216	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
700015002217	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
700015002218	active site
700015002219	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
700015002220	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
700015002221	active site
700015002222	dimer interface [polypeptide binding]; other site
700015002223	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
700015002224	dimer interface [polypeptide binding]; other site
700015002225	active site
700015002226	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
700015002227	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700015002228	motif II; other site
700015002229	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
700015002230	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700015002231	DNA-binding site [nucleotide binding]; DNA binding site
700015002232	UTRA domain; Region: UTRA; pfam07702
700015002233	Predicted membrane protein [Function unknown]; Region: COG1288
700015002234	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
700015002235	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
700015002236	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700015002237	active site
700015002238	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
700015002239	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
700015002240	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
700015002241	putative active site [active]
700015002242	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
700015002243	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
700015002244	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
700015002245	substrate binding site [chemical binding]; other site
700015002246	ATP binding site [chemical binding]; other site
700015002247	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
700015002248	substrate binding site [chemical binding]; other site
700015002249	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
700015002250	ATP binding site [chemical binding]; other site
700015002251	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
700015002252	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
700015002253	BtpA family; Region: BtpA; cl00440
700015002254	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
700015002255	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
700015002256	N- and C-terminal domain interface [polypeptide binding]; other site
700015002257	putative active site [active]
700015002258	MgATP binding site [chemical binding]; other site
700015002259	catalytic site [active]
700015002260	metal binding site [ion binding]; metal-binding site
700015002261	putative xylulose binding site [chemical binding]; other site
700015002262	putative homodimer interface [polypeptide binding]; other site
700015002263	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700015002264	active site
700015002265	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
700015002266	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
700015002267	putative ATP binding site [chemical binding]; other site
700015002268	putative substrate interface [chemical binding]; other site
700015002269	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
700015002270	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
700015002271	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
700015002272	ABC transporter; Region: ABC_tran_2; pfam12848
700015002273	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
700015002274	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700015002275	active site
700015002276	NAD synthetase; Reviewed; Region: nadE; PRK02628
700015002277	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
700015002278	multimer interface [polypeptide binding]; other site
700015002279	active site
700015002280	catalytic triad [active]
700015002281	protein interface 1 [polypeptide binding]; other site
700015002282	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
700015002283	homodimer interface [polypeptide binding]; other site
700015002284	NAD binding pocket [chemical binding]; other site
700015002285	ATP binding pocket [chemical binding]; other site
700015002286	Mg binding site [ion binding]; other site
700015002287	active-site loop [active]
700015002288	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
700015002289	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
700015002290	NAD binding site [chemical binding]; other site
700015002291	dimer interface [polypeptide binding]; other site
700015002292	substrate binding site [chemical binding]; other site
700015002293	tetramer (dimer of dimers) interface [polypeptide binding]; other site
700015002294	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
700015002295	non-specific DNA binding site [nucleotide binding]; other site
700015002296	salt bridge; other site
700015002297	sequence-specific DNA binding site [nucleotide binding]; other site
700015002298	Catalytic domain of Protein Kinases; Region: PKc; cd00180
700015002299	active site
700015002300	ATP binding site [chemical binding]; other site
700015002301	substrate binding site [chemical binding]; other site
700015002302	activation loop (A-loop); other site
700015002303	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
700015002304	Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919
700015002305	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700015002306	aspartate racemase; Region: asp_race; TIGR00035
700015002307	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
700015002308	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
700015002309	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
700015002310	Ligand binding site; other site
700015002311	Putative Catalytic site; other site
700015002312	DXD motif; other site
700015002313	Predicted membrane protein [Function unknown]; Region: COG2246
700015002314	GtrA-like protein; Region: GtrA; pfam04138
700015002315	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
700015002316	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
700015002317	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
700015002318	FMN binding site [chemical binding]; other site
700015002319	dimer interface [polypeptide binding]; other site
700015002320	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
700015002321	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700015002322	S-adenosylmethionine binding site [chemical binding]; other site
700015002323	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
700015002324	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
700015002325	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
700015002326	Walker A/P-loop; other site
700015002327	ATP binding site [chemical binding]; other site
700015002328	Q-loop/lid; other site
700015002329	ABC transporter signature motif; other site
700015002330	Walker B; other site
700015002331	D-loop; other site
700015002332	H-loop/switch region; other site
700015002333	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
700015002334	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
700015002335	Walker A/P-loop; other site
700015002336	ATP binding site [chemical binding]; other site
700015002337	Q-loop/lid; other site
700015002338	ABC transporter signature motif; other site
700015002339	Walker B; other site
700015002340	D-loop; other site
700015002341	H-loop/switch region; other site
700015002342	putative lipid kinase; Reviewed; Region: PRK13057
700015002343	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
700015002344	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
700015002345	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
700015002346	catalytic site [active]
700015002347	putative active site [active]
700015002348	putative substrate binding site [chemical binding]; other site
700015002349	HRDC domain; Region: HRDC; pfam00570
700015002350	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
700015002351	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
700015002352	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
700015002353	generic binding surface I; other site
700015002354	generic binding surface II; other site
700015002355	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
700015002356	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
700015002357	nucleotide binding site/active site [active]
700015002358	HIT family signature motif; other site
700015002359	catalytic residue [active]
700015002360	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
700015002361	propionate/acetate kinase; Provisional; Region: PRK12379
700015002362	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
700015002363	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
700015002364	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700015002365	UDP-galactopyranose mutase; Region: GLF; pfam03275
700015002366	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
700015002367	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
700015002368	active site
700015002369	Maf-like protein; Region: Maf; pfam02545
700015002370	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
700015002371	active site
700015002372	dimer interface [polypeptide binding]; other site
700015002373	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
700015002374	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700015002375	S-adenosylmethionine binding site [chemical binding]; other site
700015002376	polyphosphate kinase; Provisional; Region: PRK05443
700015002377	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
700015002378	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
700015002379	Catalytic C-terminal domain, first repeat, of uncharacterized prokaryotic polyphosphate kinases; Region: PLDc_PPK1_C1_unchar; cd09166
700015002380	putative domain interface [polypeptide binding]; other site
700015002381	putative active site [active]
700015002382	catalytic site [active]
700015002383	Catalytic C-terminal domain, second repeat, of uncharacterized prokaryotic polyphosphate kinases; Region: PLDc_PPK1_C2_unchar; cd09169
700015002384	putative domain interface [polypeptide binding]; other site
700015002385	putative active site [active]
700015002386	catalytic site [active]
700015002387	Amidinotransferase; Region: Amidinotransf; cl12043
700015002388	ornithine carbamoyltransferase; Validated; Region: PRK02102
700015002389	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
700015002390	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
700015002391	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
700015002392	hypothetical protein; Provisional; Region: PRK13663
700015002393	CTP synthetase; Validated; Region: pyrG; PRK05380
700015002394	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
700015002395	Catalytic site [active]
700015002396	active site
700015002397	UTP binding site [chemical binding]; other site
700015002398	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
700015002399	active site
700015002400	putative oxyanion hole; other site
700015002401	catalytic triad [active]
700015002402	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
700015002403	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
700015002404	active site
700015002405	Int/Topo IB signature motif; other site
700015002406	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
700015002407	MraZ protein; Region: MraZ; pfam02381
700015002408	MraZ protein; Region: MraZ; pfam02381
700015002409	MraW methylase family; Region: Methyltransf_5; pfam01795
700015002410	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
700015002411	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
700015002412	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
700015002413	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
700015002414	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
700015002415	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
700015002416	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
700015002417	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
700015002418	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
700015002419	Mg++ binding site [ion binding]; other site
700015002420	putative catalytic motif [active]
700015002421	putative substrate binding site [chemical binding]; other site
700015002422	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
700015002423	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
700015002424	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
700015002425	cell division protein FtsW; Region: ftsW; TIGR02614
700015002426	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
700015002427	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
700015002428	homodimer interface [polypeptide binding]; other site
700015002429	active site
700015002430	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
700015002431	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
700015002432	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
700015002433	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
700015002434	FAD binding domain; Region: FAD_binding_4; pfam01565
700015002435	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
700015002436	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
700015002437	cell division protein FtsZ; Validated; Region: PRK09330
700015002438	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
700015002439	nucleotide binding site [chemical binding]; other site
700015002440	SulA interaction site; other site
700015002441	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
700015002442	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
700015002443	PBP superfamily domain; Region: PBP_like_2; cl17296
700015002444	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
700015002445	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
700015002446	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700015002447	dimer interface [polypeptide binding]; other site
700015002448	conserved gate region; other site
700015002449	putative PBP binding loops; other site
700015002450	ABC-ATPase subunit interface; other site
700015002451	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
700015002452	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700015002453	dimer interface [polypeptide binding]; other site
700015002454	conserved gate region; other site
700015002455	putative PBP binding loops; other site
700015002456	ABC-ATPase subunit interface; other site
700015002457	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
700015002458	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
700015002459	Walker A/P-loop; other site
700015002460	ATP binding site [chemical binding]; other site
700015002461	Q-loop/lid; other site
700015002462	ABC transporter signature motif; other site
700015002463	Walker B; other site
700015002464	D-loop; other site
700015002465	H-loop/switch region; other site
700015002466	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
700015002467	PhoU domain; Region: PhoU; pfam01895
700015002468	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
700015002469	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
700015002470	catalytic residue [active]
700015002471	Protein of unknown function (DUF552); Region: DUF552; pfam04472
700015002472	YGGT family; Region: YGGT; pfam02325
700015002473	DivIVA protein; Region: DivIVA; pfam05103
700015002474	DivIVA domain; Region: DivI1A_domain; TIGR03544
700015002475	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
700015002476	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700015002477	DNA-binding site [nucleotide binding]; DNA binding site
700015002478	UTRA domain; Region: UTRA; pfam07702
700015002479	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
700015002480	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
700015002481	active site turn [active]
700015002482	phosphorylation site [posttranslational modification]
700015002483	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
700015002484	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
700015002485	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
700015002486	Ca binding site [ion binding]; other site
700015002487	active site
700015002488	catalytic site [active]
700015002489	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
700015002490	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
700015002491	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700015002492	non-specific DNA binding site [nucleotide binding]; other site
700015002493	salt bridge; other site
700015002494	sequence-specific DNA binding site [nucleotide binding]; other site
700015002495	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
700015002496	Catalytic site [active]
700015002497	Uncharacterized conserved protein [Function unknown]; Region: COG1739
700015002498	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
700015002499	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
700015002500	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
700015002501	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
700015002502	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
700015002503	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
700015002504	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
700015002505	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
700015002506	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
700015002507	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
700015002508	Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440
700015002509	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700015002510	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700015002511	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
700015002512	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
700015002513	active site
700015002514	NAD binding site [chemical binding]; other site
700015002515	metal binding site [ion binding]; metal-binding site
700015002516	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015002517	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700015002518	putative substrate translocation pore; other site
700015002519	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
700015002520	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
700015002521	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
700015002522	NAD(P) binding site [chemical binding]; other site
700015002523	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
700015002524	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805
700015002525	N- and C-terminal domain interface [polypeptide binding]; other site
700015002526	active site
700015002527	MgATP binding site [chemical binding]; other site
700015002528	catalytic site [active]
700015002529	metal binding site [ion binding]; metal-binding site
700015002530	xylulose binding site [chemical binding]; other site
700015002531	putative homodimer interface [polypeptide binding]; other site
700015002532	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
700015002533	intersubunit interface [polypeptide binding]; other site
700015002534	active site
700015002535	Zn2+ binding site [ion binding]; other site
700015002536	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
700015002537	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
700015002538	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700015002539	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700015002540	catalytic residue [active]
700015002541	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
700015002542	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015002543	Walker A/P-loop; other site
700015002544	ATP binding site [chemical binding]; other site
700015002545	Q-loop/lid; other site
700015002546	ABC transporter signature motif; other site
700015002547	Walker B; other site
700015002548	D-loop; other site
700015002549	H-loop/switch region; other site
700015002550	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
700015002551	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
700015002552	Walker A/P-loop; other site
700015002553	ATP binding site [chemical binding]; other site
700015002554	Q-loop/lid; other site
700015002555	ABC transporter signature motif; other site
700015002556	Walker B; other site
700015002557	D-loop; other site
700015002558	H-loop/switch region; other site
700015002559	glutamate dehydrogenase; Provisional; Region: PRK09414
700015002560	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
700015002561	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
700015002562	NAD(P) binding site [chemical binding]; other site
700015002563	CAAX protease self-immunity; Region: Abi; pfam02517
700015002564	trigger factor; Region: tig; TIGR00115
700015002565	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
700015002566	Clp protease; Region: CLP_protease; pfam00574
700015002567	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
700015002568	oligomer interface [polypeptide binding]; other site
700015002569	active site residues [active]
700015002570	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
700015002571	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
700015002572	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
700015002573	Walker B motif; other site
700015002574	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
700015002575	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
700015002576	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700015002577	active site
700015002578	HIGH motif; other site
700015002579	nucleotide binding site [chemical binding]; other site
700015002580	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
700015002581	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
700015002582	active site
700015002583	KMSKS motif; other site
700015002584	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
700015002585	tRNA binding surface [nucleotide binding]; other site
700015002586	anticodon binding site; other site
700015002587	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
700015002588	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
700015002589	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
700015002590	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
700015002591	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700015002592	motif II; other site
700015002593	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
700015002594	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
700015002595	histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856
700015002596	active site
700015002597	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
700015002598	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
700015002599	phosphate binding site [ion binding]; other site
700015002600	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
700015002601	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700015002602	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700015002603	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
700015002604	Double zinc ribbon; Region: DZR; pfam12773
700015002605	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
700015002606	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
700015002607	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
700015002608	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
700015002609	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
700015002610	active site
700015002611	dimer interface [polypeptide binding]; other site
700015002612	motif 1; other site
700015002613	motif 2; other site
700015002614	motif 3; other site
700015002615	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
700015002616	anticodon binding site; other site
700015002617	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700015002618	Thymidylate synthase; Region: Thymidylat_synt; pfam00303
700015002619	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
700015002620	dimerization interface [polypeptide binding]; other site
700015002621	active site
700015002622	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
700015002623	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
700015002624	folate binding site [chemical binding]; other site
700015002625	NADP+ binding site [chemical binding]; other site
700015002626	flavodoxin; Provisional; Region: PRK06242
700015002627	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
700015002628	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
700015002629	FtsH Extracellular; Region: FtsH_ext; pfam06480
700015002630	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
700015002631	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700015002632	Walker A motif; other site
700015002633	ATP binding site [chemical binding]; other site
700015002634	Walker B motif; other site
700015002635	arginine finger; other site
700015002636	Peptidase family M41; Region: Peptidase_M41; pfam01434
700015002637	Helix-hairpin-helix motif; Region: HHH; pfam00633
700015002638	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
700015002639	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
700015002640	Competence protein; Region: Competence; pfam03772
700015002641	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
700015002642	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700015002643	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
700015002644	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
700015002645	GTP-binding protein LepA; Provisional; Region: PRK05433
700015002646	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
700015002647	G1 box; other site
700015002648	putative GEF interaction site [polypeptide binding]; other site
700015002649	GTP/Mg2+ binding site [chemical binding]; other site
700015002650	Switch I region; other site
700015002651	G2 box; other site
700015002652	G3 box; other site
700015002653	Switch II region; other site
700015002654	G4 box; other site
700015002655	G5 box; other site
700015002656	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
700015002657	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
700015002658	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
700015002659	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
700015002660	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
700015002661	FMN binding site [chemical binding]; other site
700015002662	active site
700015002663	catalytic residues [active]
700015002664	substrate binding site [chemical binding]; other site
700015002665	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
700015002666	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700015002667	FeS/SAM binding site; other site
700015002668	HemN C-terminal domain; Region: HemN_C; pfam06969
700015002669	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
700015002670	HSP70 interaction site [polypeptide binding]; other site
700015002671	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
700015002672	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
700015002673	Zn binding sites [ion binding]; other site
700015002674	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
700015002675	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
700015002676	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
700015002677	HSP70 interaction site [polypeptide binding]; other site
700015002678	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
700015002679	substrate binding site [polypeptide binding]; other site
700015002680	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
700015002681	Zn binding sites [ion binding]; other site
700015002682	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
700015002683	dimer interface [polypeptide binding]; other site
700015002684	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
700015002685	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
700015002686	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
700015002687	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
700015002688	GTPase Era; Reviewed; Region: era; PRK00089
700015002689	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
700015002690	G1 box; other site
700015002691	GTP/Mg2+ binding site [chemical binding]; other site
700015002692	Switch I region; other site
700015002693	G2 box; other site
700015002694	Switch II region; other site
700015002695	G3 box; other site
700015002696	G4 box; other site
700015002697	G5 box; other site
700015002698	KH domain; Region: KH_2; pfam07650
700015002699	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
700015002700	Recombination protein O N terminal; Region: RecO_N; pfam11967
700015002701	Recombination protein O C terminal; Region: RecO_C; pfam02565
700015002702	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
700015002703	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
700015002704	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700015002705	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700015002706	catalytic loop [active]
700015002707	iron binding site [ion binding]; other site
700015002708	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
700015002709	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
700015002710	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
700015002711	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
700015002712	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
700015002713	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
700015002714	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
700015002715	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
700015002716	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
700015002717	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
700015002718	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136
700015002719	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015002720	Walker A/P-loop; other site
700015002721	ATP binding site [chemical binding]; other site
700015002722	Q-loop/lid; other site
700015002723	ABC transporter signature motif; other site
700015002724	Walker B; other site
700015002725	D-loop; other site
700015002726	H-loop/switch region; other site
700015002727	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
700015002728	16S/18S rRNA binding site [nucleotide binding]; other site
700015002729	S13e-L30e interaction site [polypeptide binding]; other site
700015002730	25S rRNA binding site [nucleotide binding]; other site
700015002731	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
700015002732	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
700015002733	RNase E interface [polypeptide binding]; other site
700015002734	trimer interface [polypeptide binding]; other site
700015002735	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
700015002736	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
700015002737	RNase E interface [polypeptide binding]; other site
700015002738	trimer interface [polypeptide binding]; other site
700015002739	active site
700015002740	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
700015002741	putative nucleic acid binding region [nucleotide binding]; other site
700015002742	G-X-X-G motif; other site
700015002743	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
700015002744	RNA binding site [nucleotide binding]; other site
700015002745	domain interface; other site
700015002746	Uncharacterized conserved protein [Function unknown]; Region: COG5495
700015002747	Rossmann-like domain; Region: Rossmann-like; pfam10727
700015002748	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
700015002749	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
700015002750	oligomerization interface [polypeptide binding]; other site
700015002751	active site
700015002752	metal binding site [ion binding]; metal-binding site
700015002753	pantoate--beta-alanine ligase; Region: panC; TIGR00018
700015002754	Pantoate-beta-alanine ligase; Region: PanC; cd00560
700015002755	active site
700015002756	ATP-binding site [chemical binding]; other site
700015002757	pantoate-binding site; other site
700015002758	HXXH motif; other site
700015002759	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
700015002760	tetramerization interface [polypeptide binding]; other site
700015002761	active site
700015002762	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
700015002763	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
700015002764	substrate binding site [chemical binding]; other site
700015002765	ATP binding site [chemical binding]; other site
700015002766	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
700015002767	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
700015002768	Soluble P-type ATPase [General function prediction only]; Region: COG4087
700015002769	Double zinc ribbon; Region: DZR; pfam12773
700015002770	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
700015002771	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
700015002772	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700015002773	binding surface
700015002774	TPR motif; other site
700015002775	rod shape-determining protein MreB; Provisional; Region: PRK13927
700015002776	MreB and similar proteins; Region: MreB_like; cd10225
700015002777	nucleotide binding site [chemical binding]; other site
700015002778	Mg binding site [ion binding]; other site
700015002779	putative protofilament interaction site [polypeptide binding]; other site
700015002780	RodZ interaction site [polypeptide binding]; other site
700015002781	rod shape-determining protein MreC; Provisional; Region: PRK13922
700015002782	rod shape-determining protein MreC; Region: MreC; pfam04085
700015002783	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
700015002784	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
700015002785	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
700015002786	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
700015002787	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
700015002788	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
700015002789	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
700015002790	B12 binding site [chemical binding]; other site
700015002791	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700015002792	FeS/SAM binding site; other site
700015002793	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
700015002794	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
700015002795	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
700015002796	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
700015002797	GTPase CgtA; Reviewed; Region: obgE; PRK12297
700015002798	GTP1/OBG; Region: GTP1_OBG; pfam01018
700015002799	Obg GTPase; Region: Obg; cd01898
700015002800	G1 box; other site
700015002801	GTP/Mg2+ binding site [chemical binding]; other site
700015002802	Switch I region; other site
700015002803	G2 box; other site
700015002804	G3 box; other site
700015002805	Switch II region; other site
700015002806	G4 box; other site
700015002807	G5 box; other site
700015002808	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
700015002809	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
700015002810	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
700015002811	active site
700015002812	(T/H)XGH motif; other site
700015002813	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
700015002814	Zn2+ binding site [ion binding]; other site
700015002815	Mg2+ binding site [ion binding]; other site
700015002816	Oligomerisation domain; Region: Oligomerisation; pfam02410
700015002817	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
700015002818	active site
700015002819	DNA polymerase IV; Validated; Region: PRK02406
700015002820	DNA binding site [nucleotide binding]
700015002821	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
700015002822	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
700015002823	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
700015002824	KH domain; Region: KH_4; pfam13083
700015002825	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
700015002826	RimM N-terminal domain; Region: RimM; pfam01782
700015002827	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
700015002828	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
700015002829	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
700015002830	Catalytic site [active]
700015002831	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
700015002832	dimer interface [polypeptide binding]; other site
700015002833	motif 1; other site
700015002834	active site
700015002835	motif 2; other site
700015002836	motif 3; other site
700015002837	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
700015002838	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
700015002839	PEP synthetase regulatory protein; Provisional; Region: PRK05339
700015002840	pyruvate phosphate dikinase; Provisional; Region: PRK09279
700015002841	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
700015002842	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
700015002843	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
700015002844	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
700015002845	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
700015002846	RNA/DNA hybrid binding site [nucleotide binding]; other site
700015002847	active site
700015002848	hypothetical protein; Reviewed; Region: PRK12497
700015002849	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
700015002850	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
700015002851	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700015002852	Walker A motif; other site
700015002853	ATP binding site [chemical binding]; other site
700015002854	Walker B motif; other site
700015002855	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
700015002856	DNA protecting protein DprA; Region: dprA; TIGR00732
700015002857	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
700015002858	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
700015002859	Glucose inhibited division protein A; Region: GIDA; pfam01134
700015002860	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
700015002861	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
700015002862	active site
700015002863	DNA binding site [nucleotide binding]
700015002864	Int/Topo IB signature motif; other site
700015002865	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
700015002866	rRNA interaction site [nucleotide binding]; other site
700015002867	S8 interaction site; other site
700015002868	putative laminin-1 binding site; other site
700015002869	elongation factor Ts; Provisional; Region: tsf; PRK09377
700015002870	UBA/TS-N domain; Region: UBA; pfam00627
700015002871	Elongation factor TS; Region: EF_TS; pfam00889
700015002872	Elongation factor TS; Region: EF_TS; pfam00889
700015002873	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
700015002874	putative nucleotide binding site [chemical binding]; other site
700015002875	uridine monophosphate binding site [chemical binding]; other site
700015002876	homohexameric interface [polypeptide binding]; other site
700015002877	ribosome recycling factor; Reviewed; Region: frr; PRK00083
700015002878	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
700015002879	hinge region; other site
700015002880	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
700015002881	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
700015002882	catalytic residue [active]
700015002883	putative FPP diphosphate  binding site; other site
700015002884	putative FPP binding hydrophobic cleft; other site
700015002885	dimer interface [polypeptide binding]; other site
700015002886	putative IPP diphosphate binding site; other site
700015002887	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
700015002888	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
700015002889	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
700015002890	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
700015002891	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
700015002892	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
700015002893	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
700015002894	active site
700015002895	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
700015002896	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
700015002897	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
700015002898	putative substrate binding region [chemical binding]; other site
700015002899	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
700015002900	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
700015002901	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
700015002902	prolyl-tRNA synthetase; Provisional; Region: PRK09194
700015002903	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
700015002904	dimer interface [polypeptide binding]; other site
700015002905	motif 1; other site
700015002906	active site
700015002907	motif 2; other site
700015002908	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
700015002909	putative deacylase active site [active]
700015002910	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
700015002911	active site
700015002912	motif 3; other site
700015002913	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
700015002914	anticodon binding site; other site
700015002915	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
700015002916	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
700015002917	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
700015002918	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
700015002919	ABC transporter; Region: ABC_tran_2; pfam12848
700015002920	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
700015002921	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
700015002922	Peptidase family M50; Region: Peptidase_M50; pfam02163
700015002923	active site
700015002924	putative substrate binding region [chemical binding]; other site
700015002925	ScpA/B protein; Region: ScpA_ScpB; cl00598
700015002926	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
700015002927	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
700015002928	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
700015002929	RNA binding surface [nucleotide binding]; other site
700015002930	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
700015002931	active site
700015002932	cytidylate kinase; Provisional; Region: cmk; PRK00023
700015002933	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
700015002934	CMP-binding site; other site
700015002935	The sites determining sugar specificity; other site
700015002936	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
700015002937	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
700015002938	putative acyl-acceptor binding pocket; other site
700015002939	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
700015002940	LytB protein; Region: LYTB; cl00507
700015002941	GTP-binding protein Der; Reviewed; Region: PRK00093
700015002942	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
700015002943	G1 box; other site
700015002944	GTP/Mg2+ binding site [chemical binding]; other site
700015002945	Switch I region; other site
700015002946	G2 box; other site
700015002947	Switch II region; other site
700015002948	G3 box; other site
700015002949	G4 box; other site
700015002950	G5 box; other site
700015002951	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
700015002952	G1 box; other site
700015002953	GTP/Mg2+ binding site [chemical binding]; other site
700015002954	Switch I region; other site
700015002955	G2 box; other site
700015002956	G3 box; other site
700015002957	Switch II region; other site
700015002958	G4 box; other site
700015002959	G5 box; other site
700015002960	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
700015002961	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
700015002962	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
700015002963	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
700015002964	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
700015002965	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
700015002966	substrate binding site [chemical binding]; other site
700015002967	hexamer interface [polypeptide binding]; other site
700015002968	metal binding site [ion binding]; metal-binding site
700015002969	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700015002970	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
700015002971	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700015002972	catalytic residue [active]
700015002973	Uncharacterized conserved protein [Function unknown]; Region: COG0327
700015002974	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
700015002975	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
700015002976	Putative zinc ribbon domain; Region: DUF164; pfam02591
700015002977	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
700015002978	Flavoprotein; Region: Flavoprotein; pfam02441
700015002979	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
700015002980	AAA domain; Region: AAA_13; pfam13166
700015002981	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
700015002982	Predicted integral membrane protein [Function unknown]; Region: COG5658
700015002983	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
700015002984	SdpI/YhfL protein family; Region: SdpI; pfam13630
700015002985	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
700015002986	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
700015002987	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
700015002988	active site
700015002989	metal binding site [ion binding]; metal-binding site
700015002990	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
700015002991	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
700015002992	active site
700015002993	P-loop; other site
700015002994	phosphorylation site [posttranslational modification]
700015002995	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
700015002996	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
700015002997	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
700015002998	active site
700015002999	phosphorylation site [posttranslational modification]
700015003000	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
700015003001	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
700015003002	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
700015003003	putative active site [active]
700015003004	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
700015003005	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
700015003006	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
700015003007	beta-galactosidase; Region: BGL; TIGR03356
700015003008	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
700015003009	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700015003010	DNA-binding site [nucleotide binding]; DNA binding site
700015003011	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
700015003012	[FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956
700015003013	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700015003014	FeS/SAM binding site; other site
700015003015	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
700015003016	[FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955
700015003017	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700015003018	FeS/SAM binding site; other site
700015003019	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
700015003020	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cl01843
700015003021	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
700015003022	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
700015003023	G1 box; other site
700015003024	GTP/Mg2+ binding site [chemical binding]; other site
700015003025	Switch I region; other site
700015003026	G2 box; other site
700015003027	Switch II region; other site
700015003028	G3 box; other site
700015003029	G4 box; other site
700015003030	G5 box; other site
700015003031	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
700015003032	M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896
700015003033	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
700015003034	putative metal binding site [ion binding]; other site
700015003035	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
700015003036	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
700015003037	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
700015003038	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
700015003039	intersubunit interface [polypeptide binding]; other site
700015003040	active site
700015003041	zinc binding site [ion binding]; other site
700015003042	Na+ binding site [ion binding]; other site
700015003043	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
700015003044	active pocket/dimerization site; other site
700015003045	active site
700015003046	phosphorylation site [posttranslational modification]
700015003047	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
700015003048	active site
700015003049	phosphorylation site [posttranslational modification]
700015003050	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
700015003051	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
700015003052	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
700015003053	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
700015003054	NAD(P) binding site [chemical binding]; other site
700015003055	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
700015003056	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
700015003057	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
700015003058	phosphopeptide binding site; other site
700015003059	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
700015003060	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
700015003061	DNA binding residues [nucleotide binding]
700015003062	dimer interface [polypeptide binding]; other site
700015003063	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700015003064	active site
700015003065	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
700015003066	NlpC/P60 family; Region: NLPC_P60; pfam00877
700015003067	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
700015003068	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
700015003069	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
700015003070	NlpC/P60 family; Region: NLPC_P60; pfam00877
700015003071	EDD domain protein, DegV family; Region: DegV; TIGR00762
700015003072	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
700015003073	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
700015003074	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700015003075	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700015003076	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
700015003077	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
700015003078	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700015003079	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
700015003080	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
700015003081	trimer interface [polypeptide binding]; other site
700015003082	active site
700015003083	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
700015003084	Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609
700015003085	ATP cone domain; Region: ATP-cone; pfam03477
700015003086	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
700015003087	LexA repressor; Validated; Region: PRK00215
700015003088	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700015003089	putative DNA binding site [nucleotide binding]; other site
700015003090	putative Zn2+ binding site [ion binding]; other site
700015003091	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
700015003092	Catalytic site [active]
700015003093	Protein of unknown function (DUF1624); Region: DUF1624; pfam07786
700015003094	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
700015003095	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
700015003096	HflX GTPase family; Region: HflX; cd01878
700015003097	G1 box; other site
700015003098	GTP/Mg2+ binding site [chemical binding]; other site
700015003099	Switch I region; other site
700015003100	G2 box; other site
700015003101	G3 box; other site
700015003102	Switch II region; other site
700015003103	G4 box; other site
700015003104	G5 box; other site
700015003105	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
700015003106	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
700015003107	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
700015003108	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
700015003109	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700015003110	FeS/SAM binding site; other site
700015003111	TRAM domain; Region: TRAM; pfam01938
700015003112	Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005
700015003113	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700015003114	ATP binding site [chemical binding]; other site
700015003115	Mg2+ binding site [ion binding]; other site
700015003116	G-X-G motif; other site
700015003117	phosphodiesterase; Provisional; Region: PRK12704
700015003118	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
700015003119	Zn2+ binding site [ion binding]; other site
700015003120	Mg2+ binding site [ion binding]; other site
700015003121	recombination regulator RecX; Reviewed; Region: recX; PRK00117
700015003122	recombinase A; Provisional; Region: recA; PRK09354
700015003123	recA bacterial DNA recombination protein; Region: RecA; cl17211
700015003124	Competence-damaged protein; Region: CinA; pfam02464
700015003125	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
700015003126	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
700015003127	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
700015003128	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
700015003129	FeS/SAM binding site; other site
700015003130	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
700015003131	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
700015003132	Helix-turn-helix domain; Region: HTH_25; pfam13413
700015003133	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
700015003134	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
700015003135	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
700015003136	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
700015003137	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
700015003138	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700015003139	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
700015003140	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
700015003141	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015003142	Walker A/P-loop; other site
700015003143	ATP binding site [chemical binding]; other site
700015003144	Q-loop/lid; other site
700015003145	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
700015003146	ABC transporter signature motif; other site
700015003147	Walker B; other site
700015003148	D-loop; other site
700015003149	H-loop/switch region; other site
700015003150	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
700015003151	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
700015003152	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
700015003153	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700015003154	S-adenosylmethionine binding site [chemical binding]; other site
700015003155	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
700015003156	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
700015003157	elongation factor P; Validated; Region: PRK00529
700015003158	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
700015003159	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
700015003160	RNA binding site [nucleotide binding]; other site
700015003161	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
700015003162	RNA binding site [nucleotide binding]; other site
700015003163	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
700015003164	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
700015003165	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
700015003166	active site
700015003167	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
700015003168	active site
700015003169	NAD binding site [chemical binding]; other site
700015003170	shikimate kinase; Reviewed; Region: aroK; PRK00131
700015003171	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
700015003172	ADP binding site [chemical binding]; other site
700015003173	magnesium binding site [ion binding]; other site
700015003174	putative shikimate binding site; other site
700015003175	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase
700015003176	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700015003177	active site
700015003178	motif I; other site
700015003179	motif II; other site
700015003180	YceG-like family; Region: YceG; pfam02618
700015003181	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
700015003182	dimerization interface [polypeptide binding]; other site
700015003183	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
700015003184	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
700015003185	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
700015003186	motif 1; other site
700015003187	active site
700015003188	motif 2; other site
700015003189	motif 3; other site
700015003190	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
700015003191	DHHA1 domain; Region: DHHA1; pfam02272
700015003192	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
700015003193	Domain of unknown function DUF20; Region: UPF0118; pfam01594
700015003194	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
700015003195	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700015003196	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
700015003197	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700015003198	DNA binding residues [nucleotide binding]
700015003199	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
700015003200	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
700015003201	recombination factor protein RarA; Reviewed; Region: PRK13342
700015003202	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700015003203	Walker A motif; other site
700015003204	ATP binding site [chemical binding]; other site
700015003205	Walker B motif; other site
700015003206	arginine finger; other site
700015003207	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
700015003208	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
700015003209	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
700015003210	Zn2+ binding site [ion binding]; other site
700015003211	Mg2+ binding site [ion binding]; other site
700015003212	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
700015003213	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
700015003214	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
700015003215	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
700015003216	active site
700015003217	active pocket/dimerization site; other site
700015003218	phosphorylation site [posttranslational modification]
700015003219	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
700015003220	active site
700015003221	phosphorylation site [posttranslational modification]
700015003222	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
700015003223	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
700015003224	Domain of unknown function (DUF956); Region: DUF956; pfam06115
700015003225	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
700015003226	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
700015003227	DXD motif; other site
700015003228	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
700015003229	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
700015003230	RNA binding surface [nucleotide binding]; other site
700015003231	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
700015003232	active site
700015003233	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
700015003234	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
700015003235	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700015003236	active site
700015003237	HIGH motif; other site
700015003238	nucleotide binding site [chemical binding]; other site
700015003239	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
700015003240	active site
700015003241	KMSKS motif; other site
700015003242	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
700015003243	tRNA binding surface [nucleotide binding]; other site
700015003244	anticodon binding site; other site
700015003245	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
700015003246	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
700015003247	putative metal binding site [ion binding]; other site
700015003248	Uncharacterized conserved protein [Function unknown]; Region: COG1432
700015003249	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
700015003250	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
700015003251	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
700015003252	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
700015003253	Ligand Binding Site [chemical binding]; other site
700015003254	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
700015003255	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
700015003256	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
700015003257	catalytic site [active]
700015003258	G-X2-G-X-G-K; other site
700015003259	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
700015003260	active site
700015003261	dimer interface [polypeptide binding]; other site
700015003262	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
700015003263	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
700015003264	benzoate transport; Region: 2A0115; TIGR00895
700015003265	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015003266	putative substrate translocation pore; other site
700015003267	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
700015003268	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
700015003269	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
700015003270	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
700015003271	heterodimer interface [polypeptide binding]; other site
700015003272	active site
700015003273	FMN binding site [chemical binding]; other site
700015003274	homodimer interface [polypeptide binding]; other site
700015003275	substrate binding site [chemical binding]; other site
700015003276	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
700015003277	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
700015003278	FAD binding pocket [chemical binding]; other site
700015003279	FAD binding motif [chemical binding]; other site
700015003280	phosphate binding motif [ion binding]; other site
700015003281	beta-alpha-beta structure motif; other site
700015003282	NAD binding pocket [chemical binding]; other site
700015003283	Iron coordination center [ion binding]; other site
700015003284	dihydroorotase; Validated; Region: pyrC; PRK09357
700015003285	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700015003286	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
700015003287	active site
700015003288	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
700015003289	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
700015003290	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
700015003291	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
700015003292	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700015003293	active site
700015003294	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
700015003295	domain interaction interfaces [polypeptide binding]; other site
700015003296	Cna protein B-type domain; Region: Cna_B; pfam05738
700015003297	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
700015003298	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
700015003299	Walker A/P-loop; other site
700015003300	ATP binding site [chemical binding]; other site
700015003301	Q-loop/lid; other site
700015003302	ABC transporter signature motif; other site
700015003303	Walker B; other site
700015003304	D-loop; other site
700015003305	H-loop/switch region; other site
700015003306	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
700015003307	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
700015003308	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
700015003309	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
700015003310	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700015003311	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
700015003312	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700015003313	DNA binding residues [nucleotide binding]
700015003314	DNA primase, catalytic core; Region: dnaG; TIGR01391
700015003315	CHC2 zinc finger; Region: zf-CHC2; cl17510
700015003316	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
700015003317	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
700015003318	active site
700015003319	metal binding site [ion binding]; metal-binding site
700015003320	interdomain interaction site; other site
700015003321	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
700015003322	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
700015003323	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
700015003324	active site
700015003325	Riboflavin kinase; Region: Flavokinase; pfam01687
700015003326	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
700015003327	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
700015003328	RNA binding site [nucleotide binding]; other site
700015003329	active site
700015003330	DHH family; Region: DHH; pfam01368
700015003331	Ribosome-binding factor A; Region: RBFA; pfam02033
700015003332	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
700015003333	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
700015003334	translation initiation factor IF-2; Region: IF-2; TIGR00487
700015003335	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
700015003336	G1 box; other site
700015003337	putative GEF interaction site [polypeptide binding]; other site
700015003338	GTP/Mg2+ binding site [chemical binding]; other site
700015003339	Switch I region; other site
700015003340	G2 box; other site
700015003341	G3 box; other site
700015003342	Switch II region; other site
700015003343	G4 box; other site
700015003344	G5 box; other site
700015003345	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
700015003346	Translation-initiation factor 2; Region: IF-2; pfam11987
700015003347	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
700015003348	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
700015003349	NusA N-terminal domain; Region: NusA_N; pfam08529
700015003350	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
700015003351	RNA binding site [nucleotide binding]; other site
700015003352	homodimer interface [polypeptide binding]; other site
700015003353	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
700015003354	G-X-X-G motif; other site
700015003355	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
700015003356	G-X-X-G motif; other site
700015003357	CCCH zinc finger in TRM13 protein; Region: zf-TRM13_CCCH; pfam11722
700015003358	ribosome maturation protein RimP; Reviewed; Region: PRK00092
700015003359	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
700015003360	putative oligomer interface [polypeptide binding]; other site
700015003361	putative RNA binding site [nucleotide binding]; other site
700015003362	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
700015003363	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
700015003364	HIGH motif; other site
700015003365	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
700015003366	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700015003367	active site
700015003368	KMSKS motif; other site
700015003369	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
700015003370	tRNA binding surface [nucleotide binding]; other site
700015003371	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107
700015003372	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
700015003373	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602
700015003374	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
700015003375	active site
700015003376	Uncharacterized conserved protein [Function unknown]; Region: COG3589
700015003377	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
700015003378	signal recognition particle protein; Provisional; Region: PRK10867
700015003379	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
700015003380	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
700015003381	P loop; other site
700015003382	GTP binding site [chemical binding]; other site
700015003383	Signal peptide binding domain; Region: SRP_SPB; pfam02978
700015003384	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
700015003385	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
700015003386	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
700015003387	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
700015003388	AAA domain; Region: AAA_23; pfam13476
700015003389	Walker A/P-loop; other site
700015003390	ATP binding site [chemical binding]; other site
700015003391	Q-loop/lid; other site
700015003392	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
700015003393	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
700015003394	ABC transporter signature motif; other site
700015003395	Walker B; other site
700015003396	D-loop; other site
700015003397	H-loop/switch region; other site
700015003398	ribonuclease III; Reviewed; Region: rnc; PRK00102
700015003399	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
700015003400	dimerization interface [polypeptide binding]; other site
700015003401	active site
700015003402	metal binding site [ion binding]; metal-binding site
700015003403	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
700015003404	dsRNA binding site [nucleotide binding]; other site
700015003405	acyl carrier protein; Provisional; Region: acpP; PRK00982
700015003406	Fatty acid synthesis protein; Region: FA_synthesis; cl17261
700015003407	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
700015003408	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
700015003409	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
700015003410	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
700015003411	active site
700015003412	(T/H)XGH motif; other site
700015003413	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700015003414	S-adenosylmethionine binding site [chemical binding]; other site
700015003415	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
700015003416	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
700015003417	ssDNA binding site; other site
700015003418	generic binding surface II; other site
700015003419	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700015003420	ATP binding site [chemical binding]; other site
700015003421	putative Mg++ binding site [ion binding]; other site
700015003422	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700015003423	nucleotide binding region [chemical binding]; other site
700015003424	ATP-binding site [chemical binding]; other site
700015003425	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
700015003426	DAK2 domain; Region: Dak2; pfam02734
700015003427	Asp23 family; Region: Asp23; pfam03780
700015003428	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700015003429	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700015003430	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
700015003431	Walker A/P-loop; other site
700015003432	ATP binding site [chemical binding]; other site
700015003433	Q-loop/lid; other site
700015003434	ABC transporter signature motif; other site
700015003435	Walker B; other site
700015003436	D-loop; other site
700015003437	H-loop/switch region; other site
700015003438	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700015003439	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700015003440	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015003441	Walker A/P-loop; other site
700015003442	ATP binding site [chemical binding]; other site
700015003443	Q-loop/lid; other site
700015003444	ABC transporter signature motif; other site
700015003445	Walker B; other site
700015003446	D-loop; other site
700015003447	H-loop/switch region; other site
700015003448	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
700015003449	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
700015003450	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
700015003451	putative catalytic cysteine [active]
700015003452	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
700015003453	putative active site [active]
700015003454	metal binding site [ion binding]; metal-binding site
700015003455	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
700015003456	Phosphotransferase enzyme family; Region: APH; pfam01636
700015003457	active site
700015003458	ATP binding site [chemical binding]; other site
700015003459	substrate binding site [chemical binding]; other site
700015003460	Thiamine pyrophosphokinase; Region: TPK; cd07995
700015003461	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
700015003462	active site
700015003463	dimerization interface [polypeptide binding]; other site
700015003464	thiamine binding site [chemical binding]; other site
700015003465	glycogen branching enzyme; Provisional; Region: PRK12313
700015003466	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
700015003467	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
700015003468	active site
700015003469	catalytic site [active]
700015003470	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
700015003471	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
700015003472	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
700015003473	active site pocket [active]
700015003474	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
700015003475	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
700015003476	ligand binding site; other site
700015003477	oligomer interface; other site
700015003478	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
700015003479	dimer interface [polypeptide binding]; other site
700015003480	N-terminal domain interface [polypeptide binding]; other site
700015003481	sulfate 1 binding site; other site
700015003482	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
700015003483	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
700015003484	ligand binding site; other site
700015003485	oligomer interface; other site
700015003486	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
700015003487	dimer interface [polypeptide binding]; other site
700015003488	N-terminal domain interface [polypeptide binding]; other site
700015003489	sulfate 1 binding site; other site
700015003490	glycogen synthase; Provisional; Region: glgA; PRK00654
700015003491	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
700015003492	ADP-binding pocket [chemical binding]; other site
700015003493	homodimer interface [polypeptide binding]; other site
700015003494	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
700015003495	active site
700015003496	homodimer interface [polypeptide binding]; other site
700015003497	catalytic site [active]
700015003498	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
700015003499	4-alpha-glucanotransferase; Provisional; Region: PRK14508
700015003500	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
700015003501	NusB family; Region: NusB; pfam01029
700015003502	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
700015003503	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
700015003504	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
700015003505	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
700015003506	putative active site [active]
700015003507	substrate binding site [chemical binding]; other site
700015003508	putative cosubstrate binding site; other site
700015003509	catalytic site [active]
700015003510	Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911
700015003511	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
700015003512	active site
700015003513	catalytic residues [active]
700015003514	metal binding site [ion binding]; metal-binding site
700015003515	primosome assembly protein PriA; Validated; Region: PRK05580
700015003516	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700015003517	ATP binding site [chemical binding]; other site
700015003518	putative Mg++ binding site [ion binding]; other site
700015003519	helicase superfamily c-terminal domain; Region: HELICc; smart00490
700015003520	ATP-binding site [chemical binding]; other site
700015003521	S-adenosylmethionine synthetase; Validated; Region: PRK05250
700015003522	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
700015003523	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
700015003524	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
700015003525	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
700015003526	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
700015003527	HIGH motif; other site
700015003528	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
700015003529	active site
700015003530	KMSKS motif; other site
700015003531	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
700015003532	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
700015003533	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
700015003534	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
700015003535	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
700015003536	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
700015003537	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
700015003538	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
700015003539	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700015003540	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700015003541	active site
700015003542	phosphorylation site [posttranslational modification]
700015003543	intermolecular recognition site; other site
700015003544	dimerization interface [polypeptide binding]; other site
700015003545	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700015003546	DNA binding site [nucleotide binding]
700015003547	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700015003548	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700015003549	dimer interface [polypeptide binding]; other site
700015003550	phosphorylation site [posttranslational modification]
700015003551	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700015003552	ATP binding site [chemical binding]; other site
700015003553	Mg2+ binding site [ion binding]; other site
700015003554	G-X-G motif; other site
700015003555	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700015003556	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
700015003557	FtsX-like permease family; Region: FtsX; pfam02687
700015003558	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
700015003559	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
700015003560	HlyD family secretion protein; Region: HlyD_3; pfam13437
700015003561	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
700015003562	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
700015003563	Walker A/P-loop; other site
700015003564	ATP binding site [chemical binding]; other site
700015003565	Q-loop/lid; other site
700015003566	ABC transporter signature motif; other site
700015003567	Walker B; other site
700015003568	D-loop; other site
700015003569	H-loop/switch region; other site
700015003570	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
700015003571	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
700015003572	YopD protein; Region: YopD; pfam05844
700015003573	FtsX-like permease family; Region: FtsX; pfam02687
700015003574	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700015003575	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
700015003576	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
700015003577	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
700015003578	alpha-glucosidase; Provisional; Region: PRK10426
700015003579	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
700015003580	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
700015003581	putative active site [active]
700015003582	putative catalytic site [active]
700015003583	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
700015003584	active site
700015003585	intersubunit interactions; other site
700015003586	catalytic residue [active]
700015003587	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
700015003588	hexamer (dimer of trimers) interface [polypeptide binding]; other site
700015003589	substrate binding site [chemical binding]; other site
700015003590	trimer interface [polypeptide binding]; other site
700015003591	Mn binding site [ion binding]; other site
700015003592	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
700015003593	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
700015003594	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
700015003595	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
700015003596	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015003597	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
700015003598	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
700015003599	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
700015003600	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
700015003601	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
700015003602	active site
700015003603	NTP binding site [chemical binding]; other site
700015003604	metal binding triad [ion binding]; metal-binding site
700015003605	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
700015003606	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
700015003607	Zn2+ binding site [ion binding]; other site
700015003608	Mg2+ binding site [ion binding]; other site
700015003609	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
700015003610	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
700015003611	trimer interface [polypeptide binding]; other site
700015003612	active site
700015003613	G bulge; other site
700015003614	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
700015003615	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
700015003616	putative substrate binding site [chemical binding]; other site
700015003617	putative ATP binding site [chemical binding]; other site
700015003618	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
700015003619	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
700015003620	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
700015003621	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
700015003622	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
700015003623	dimerization domain swap beta strand [polypeptide binding]; other site
700015003624	regulatory protein interface [polypeptide binding]; other site
700015003625	active site
700015003626	regulatory phosphorylation site [posttranslational modification]; other site
700015003627	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
700015003628	active site
700015003629	P-loop; other site
700015003630	phosphorylation site [posttranslational modification]
700015003631	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
700015003632	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
700015003633	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
700015003634	active site
700015003635	phosphorylation site [posttranslational modification]
700015003636	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
700015003637	Ligand binding site; other site
700015003638	Putative Catalytic site; other site
700015003639	DXD motif; other site
700015003640	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700015003641	active site
700015003642	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700015003643	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
700015003644	active site
700015003645	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
700015003646	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
700015003647	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
700015003648	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
700015003649	NADP binding site [chemical binding]; other site
700015003650	active site
700015003651	putative substrate binding site [chemical binding]; other site
700015003652	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
700015003653	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
700015003654	NAD binding site [chemical binding]; other site
700015003655	substrate binding site [chemical binding]; other site
700015003656	homodimer interface [polypeptide binding]; other site
700015003657	active site
700015003658	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
700015003659	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
700015003660	substrate binding site; other site
700015003661	tetramer interface; other site
700015003662	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
700015003663	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700015003664	active site
700015003665	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
700015003666	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
700015003667	Probable Catalytic site; other site
700015003668	metal-binding site
700015003669	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
700015003670	The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains.   LytC is composed of a...; Region: GH25_LytC-like; cd06414
700015003671	active site
700015003672	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
700015003673	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
700015003674	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
700015003675	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700015003676	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700015003677	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
700015003678	Ligand binding site; other site
700015003679	Putative Catalytic site; other site
700015003680	DXD motif; other site
700015003681	putative glycosyl transferase; Provisional; Region: PRK10073
700015003682	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
700015003683	active site
700015003684	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
700015003685	4Fe-4S binding domain; Region: Fer4_6; pfam12837
700015003686	4Fe-4S binding domain; Region: Fer4_6; pfam12837
700015003687	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
700015003688	Rrf2 family protein; Region: rrf2_super; TIGR00738
700015003689	Transcriptional regulator; Region: Rrf2; cl17282
700015003690	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
700015003691	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015003692	Walker A/P-loop; other site
700015003693	ATP binding site [chemical binding]; other site
700015003694	Q-loop/lid; other site
700015003695	ABC transporter signature motif; other site
700015003696	Walker B; other site
700015003697	D-loop; other site
700015003698	H-loop/switch region; other site
700015003699	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
700015003700	FeS assembly protein SufB; Region: sufB; TIGR01980
700015003701	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
700015003702	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
700015003703	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
700015003704	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
700015003705	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700015003706	catalytic residue [active]
700015003707	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
700015003708	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
700015003709	trimerization site [polypeptide binding]; other site
700015003710	active site
700015003711	GGGtGRT protein; Region: GGGtGRT; pfam14057
700015003712	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
700015003713	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
700015003714	Predicted integral membrane protein [Function unknown]; Region: COG5652
700015003715	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
700015003716	classical (c) SDRs; Region: SDR_c; cd05233
700015003717	NAD(P) binding site [chemical binding]; other site
700015003718	active site
700015003719	transcription termination factor Rho; Provisional; Region: rho; PRK09376
700015003720	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
700015003721	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
700015003722	RNA binding site [nucleotide binding]; other site
700015003723	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
700015003724	Walker A motif; other site
700015003725	ATP binding site [chemical binding]; other site
700015003726	Walker B motif; other site
700015003727	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
700015003728	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
700015003729	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700015003730	active site
700015003731	HIGH motif; other site
700015003732	nucleotide binding site [chemical binding]; other site
700015003733	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
700015003734	KMSK motif region; other site
700015003735	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
700015003736	tRNA binding surface [nucleotide binding]; other site
700015003737	anticodon binding site; other site
700015003738	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
700015003739	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
700015003740	dimer interface [polypeptide binding]; other site
700015003741	catalytic triad [active]
700015003742	peroxidatic and resolving cysteines [active]
700015003743	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
700015003744	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
700015003745	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
700015003746	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
700015003747	Uncharacterized BCR, COG1636; Region: DUF208; cl17782
700015003748	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700015003749	active site
700015003750	HIGH motif; other site
700015003751	nucleotide binding site [chemical binding]; other site
700015003752	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700015003753	active site
700015003754	KMSKS motif; other site
700015003755	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
700015003756	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
700015003757	ABC1 family; Region: ABC1; cl17513
700015003758	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
700015003759	DNA-binding site [nucleotide binding]; DNA binding site
700015003760	RNA-binding motif; other site
700015003761	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
700015003762	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
700015003763	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
700015003764	homodimer interface [polypeptide binding]; other site
700015003765	NADP binding site [chemical binding]; other site
700015003766	substrate binding site [chemical binding]; other site
700015003767	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
700015003768	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
700015003769	Potassium binding sites [ion binding]; other site
700015003770	Cesium cation binding sites [ion binding]; other site
700015003771	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
700015003772	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700015003773	Walker A motif; other site
700015003774	ATP binding site [chemical binding]; other site
700015003775	Walker B motif; other site
700015003776	arginine finger; other site
700015003777	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
700015003778	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
700015003779	RuvA N terminal domain; Region: RuvA_N; pfam01330
700015003780	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
700015003781	active site
700015003782	putative DNA-binding cleft [nucleotide binding]; other site
700015003783	dimer interface [polypeptide binding]; other site
700015003784	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
700015003785	active site
700015003786	dimer interface [polypeptide binding]; other site
700015003787	Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014
700015003788	non-heme iron binding site [ion binding]; other site
700015003789	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700015003790	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
700015003791	active site
700015003792	catalytic tetrad [active]
700015003793	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
700015003794	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
700015003795	beta-galactosidase; Region: BGL; TIGR03356
700015003796	methionine cluster; other site
700015003797	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166
700015003798	active site
700015003799	phosphorylation site [posttranslational modification]
700015003800	metal binding site [ion binding]; metal-binding site
700015003801	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
700015003802	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
700015003803	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
700015003804	active site
700015003805	P-loop; other site
700015003806	phosphorylation site [posttranslational modification]
700015003807	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
700015003808	dimerization domain swap beta strand [polypeptide binding]; other site
700015003809	regulatory protein interface [polypeptide binding]; other site
700015003810	active site
700015003811	regulatory phosphorylation site [posttranslational modification]; other site
700015003812	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
700015003813	Mga helix-turn-helix domain; Region: Mga; pfam05043
700015003814	PRD domain; Region: PRD; pfam00874
700015003815	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
700015003816	active site
700015003817	P-loop; other site
700015003818	phosphorylation site [posttranslational modification]
700015003819	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
700015003820	active site
700015003821	phosphorylation site [posttranslational modification]
700015003822	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
700015003823	active site
700015003824	P-loop; other site
700015003825	phosphorylation site [posttranslational modification]
700015003826	Chain length determinant protein; Region: Wzz; cl15801
700015003827	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
700015003828	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700015003829	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700015003830	non-specific DNA binding site [nucleotide binding]; other site
700015003831	salt bridge; other site
700015003832	sequence-specific DNA binding site [nucleotide binding]; other site
700015003833	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700015003834	non-specific DNA binding site [nucleotide binding]; other site
700015003835	salt bridge; other site
700015003836	sequence-specific DNA binding site [nucleotide binding]; other site
700015003837	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
700015003838	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
700015003839	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
700015003840	NAD binding site [chemical binding]; other site
700015003841	sugar binding site [chemical binding]; other site
700015003842	divalent metal binding site [ion binding]; other site
700015003843	tetramer (dimer of dimers) interface [polypeptide binding]; other site
700015003844	dimer interface [polypeptide binding]; other site
700015003845	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
700015003846	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
700015003847	substrate binding site [chemical binding]; other site
700015003848	ATP binding site [chemical binding]; other site
700015003849	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
700015003850	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015003851	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700015003852	putative substrate translocation pore; other site
700015003853	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
700015003854	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
700015003855	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
700015003856	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700015003857	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700015003858	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
700015003859	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
700015003860	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700015003861	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
700015003862	active site
700015003863	Cupin domain; Region: Cupin_2; cl17218
700015003864	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
700015003865	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
700015003866	active site
700015003867	substrate binding site [chemical binding]; other site
700015003868	metal binding site [ion binding]; metal-binding site
700015003869	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
700015003870	Bacterial sugar transferase; Region: Bac_transf; pfam02397
700015003871	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
700015003872	transcription termination/antitermination factor NusG; Region: nusG; TIGR00922
700015003873	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
700015003874	heterodimer interface [polypeptide binding]; other site
700015003875	homodimer interface [polypeptide binding]; other site
700015003876	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
700015003877	active site
700015003878	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
700015003879	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
700015003880	active site
700015003881	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
700015003882	generic binding surface I; other site
700015003883	generic binding surface II; other site
700015003884	dipeptidase PepV; Reviewed; Region: PRK07318
700015003885	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
700015003886	active site
700015003887	metal binding site [ion binding]; metal-binding site
700015003888	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
700015003889	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700015003890	motif II; other site
700015003891	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
700015003892	RNA binding site [nucleotide binding]; other site
700015003893	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
700015003894	RNA binding site [nucleotide binding]; other site
700015003895	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
700015003896	RNA binding site [nucleotide binding]; other site
700015003897	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
700015003898	RNA binding site [nucleotide binding]; other site
700015003899	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
700015003900	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
700015003901	motif II; other site
700015003902	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
700015003903	active site
700015003904	multimer interface [polypeptide binding]; other site
700015003905	argininosuccinate lyase; Provisional; Region: PRK00855
700015003906	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
700015003907	active sites [active]
700015003908	tetramer interface [polypeptide binding]; other site
700015003909	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
700015003910	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
700015003911	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700015003912	S-adenosylmethionine binding site [chemical binding]; other site
700015003913	DNA polymerase I; Provisional; Region: PRK05755
700015003914	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
700015003915	active site
700015003916	metal binding site 1 [ion binding]; metal-binding site
700015003917	putative 5' ssDNA interaction site; other site
700015003918	metal binding site 3; metal-binding site
700015003919	metal binding site 2 [ion binding]; metal-binding site
700015003920	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
700015003921	putative DNA binding site [nucleotide binding]; other site
700015003922	putative metal binding site [ion binding]; other site
700015003923	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
700015003924	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
700015003925	active site
700015003926	DNA binding site [nucleotide binding]
700015003927	catalytic site [active]
700015003928	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
700015003929	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
700015003930	oligomer interface [polypeptide binding]; other site
700015003931	putative active site [active]
700015003932	metal binding site [ion binding]; metal-binding site
700015003933	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
700015003934	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
700015003935	Walker A/P-loop; other site
700015003936	ATP binding site [chemical binding]; other site
700015003937	Q-loop/lid; other site
700015003938	ABC transporter signature motif; other site
700015003939	Walker B; other site
700015003940	D-loop; other site
700015003941	H-loop/switch region; other site
700015003942	TOBE domain; Region: TOBE_2; pfam08402
700015003943	4-alpha-glucanotransferase; Provisional; Region: PRK14508
700015003944	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700015003945	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700015003946	DNA binding site [nucleotide binding]
700015003947	domain linker motif; other site
700015003948	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700015003949	ligand binding site [chemical binding]; other site
700015003950	dimerization interface [polypeptide binding]; other site
700015003951	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
700015003952	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700015003953	dimer interface [polypeptide binding]; other site
700015003954	conserved gate region; other site
700015003955	putative PBP binding loops; other site
700015003956	ABC-ATPase subunit interface; other site
700015003957	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
700015003958	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700015003959	dimer interface [polypeptide binding]; other site
700015003960	conserved gate region; other site
700015003961	putative PBP binding loops; other site
700015003962	ABC-ATPase subunit interface; other site
700015003963	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
700015003964	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
700015003965	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
700015003966	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
700015003967	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
700015003968	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
700015003969	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
700015003970	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
700015003971	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
700015003972	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700015003973	dimer interface [polypeptide binding]; other site
700015003974	conserved gate region; other site
700015003975	putative PBP binding loops; other site
700015003976	ABC-ATPase subunit interface; other site
700015003977	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
700015003978	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700015003979	dimer interface [polypeptide binding]; other site
700015003980	conserved gate region; other site
700015003981	putative PBP binding loops; other site
700015003982	ABC-ATPase subunit interface; other site
700015003983	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
700015003984	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
700015003985	Walker A/P-loop; other site
700015003986	ATP binding site [chemical binding]; other site
700015003987	Q-loop/lid; other site
700015003988	ABC transporter signature motif; other site
700015003989	Walker B; other site
700015003990	D-loop; other site
700015003991	H-loop/switch region; other site
700015003992	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
700015003993	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
700015003994	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
700015003995	Walker A/P-loop; other site
700015003996	ATP binding site [chemical binding]; other site
700015003997	Q-loop/lid; other site
700015003998	ABC transporter signature motif; other site
700015003999	Walker B; other site
700015004000	D-loop; other site
700015004001	H-loop/switch region; other site
700015004002	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
700015004003	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
700015004004	ThiC family; Region: ThiC; pfam01964
700015004005	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
700015004006	substrate binding site [chemical binding]; other site
700015004007	multimerization interface [polypeptide binding]; other site
700015004008	ATP binding site [chemical binding]; other site
700015004009	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
700015004010	thiamine phosphate binding site [chemical binding]; other site
700015004011	active site
700015004012	pyrophosphate binding site [ion binding]; other site
700015004013	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
700015004014	dimer interface [polypeptide binding]; other site
700015004015	substrate binding site [chemical binding]; other site
700015004016	ATP binding site [chemical binding]; other site
700015004017	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
700015004018	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
700015004019	putative NAD(P) binding site [chemical binding]; other site
700015004020	catalytic Zn binding site [ion binding]; other site
700015004021	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
700015004022	active site
700015004023	phosphorylation site [posttranslational modification]
700015004024	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
700015004025	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
700015004026	substrate binding site [chemical binding]; other site
700015004027	hexamer interface [polypeptide binding]; other site
700015004028	metal binding site [ion binding]; metal-binding site
700015004029	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
700015004030	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
700015004031	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
700015004032	active pocket/dimerization site; other site
700015004033	active site
700015004034	phosphorylation site [posttranslational modification]
700015004035	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700015004036	non-specific DNA binding site [nucleotide binding]; other site
700015004037	salt bridge; other site
700015004038	sequence-specific DNA binding site [nucleotide binding]; other site
700015004039	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700015004040	non-specific DNA binding site [nucleotide binding]; other site
700015004041	salt bridge; other site
700015004042	sequence-specific DNA binding site [nucleotide binding]; other site
700015004043	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
700015004044	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019
700015004045	metal binding site [ion binding]; metal-binding site
700015004046	putative dimer interface [polypeptide binding]; other site
700015004047	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
700015004048	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
700015004049	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
700015004050	CPxP  motif; other site
700015004051	DsrE/DsrF-like family; Region: DrsE; pfam02635
700015004052	Protein of unknown function, DUF488; Region: DUF488; pfam04343
700015004053	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
700015004054	anti sigma factor interaction site; other site
700015004055	regulatory phosphorylation site [posttranslational modification]; other site
700015004056	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
700015004057	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
700015004058	ATP binding site [chemical binding]; other site
700015004059	Mg2+ binding site [ion binding]; other site
700015004060	G-X-G motif; other site
700015004061	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
700015004062	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
700015004063	PAS domain; Region: PAS_9; pfam13426
700015004064	GAF domain; Region: GAF_2; pfam13185
700015004065	GAF domain; Region: GAF; pfam01590
700015004066	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
700015004067	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
700015004068	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
700015004069	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
700015004070	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
700015004071	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
700015004072	Walker A/P-loop; other site
700015004073	ATP binding site [chemical binding]; other site
700015004074	Q-loop/lid; other site
700015004075	ABC transporter signature motif; other site
700015004076	Walker B; other site
700015004077	D-loop; other site
700015004078	H-loop/switch region; other site
700015004079	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
700015004080	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
700015004081	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
700015004082	Walker A/P-loop; other site
700015004083	ATP binding site [chemical binding]; other site
700015004084	Q-loop/lid; other site
700015004085	ABC transporter signature motif; other site
700015004086	Walker B; other site
700015004087	D-loop; other site
700015004088	H-loop/switch region; other site
700015004089	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
700015004090	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
700015004091	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700015004092	dimer interface [polypeptide binding]; other site
700015004093	conserved gate region; other site
700015004094	putative PBP binding loops; other site
700015004095	ABC-ATPase subunit interface; other site
700015004096	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
700015004097	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700015004098	dimer interface [polypeptide binding]; other site
700015004099	conserved gate region; other site
700015004100	putative PBP binding loops; other site
700015004101	ABC-ATPase subunit interface; other site
700015004102	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
700015004103	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
700015004104	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
700015004105	phosphoglyceromutase; Provisional; Region: PRK05434
700015004106	triosephosphate isomerase; Provisional; Region: PRK14567
700015004107	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
700015004108	substrate binding site [chemical binding]; other site
700015004109	dimer interface [polypeptide binding]; other site
700015004110	catalytic triad [active]
700015004111	Phosphoglycerate kinase; Region: PGK; pfam00162
700015004112	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
700015004113	substrate binding site [chemical binding]; other site
700015004114	hinge regions; other site
700015004115	ADP binding site [chemical binding]; other site
700015004116	catalytic site [active]
700015004117	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
700015004118	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
700015004119	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
700015004120	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
700015004121	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
700015004122	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
700015004123	phosphate binding site [ion binding]; other site
700015004124	putative substrate binding pocket [chemical binding]; other site
700015004125	dimer interface [polypeptide binding]; other site
700015004126	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
700015004127	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
700015004128	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
700015004129	Ligand binding site; other site
700015004130	Putative Catalytic site; other site
700015004131	DXD motif; other site
700015004132	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
700015004133	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
700015004134	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
700015004135	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
700015004136	GIY-YIG motif/motif A; other site
700015004137	active site
700015004138	catalytic site [active]
700015004139	putative DNA binding site [nucleotide binding]; other site
700015004140	metal binding site [ion binding]; metal-binding site
700015004141	UvrB/uvrC motif; Region: UVR; pfam02151
700015004142	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
700015004143	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
700015004144	MviN-like protein; Region: MVIN; pfam03023
700015004145	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
700015004146	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
700015004147	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
700015004148	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
700015004149	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
700015004150	AAA domain; Region: AAA_31; pfam13614
700015004151	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
700015004152	Walker A motif; other site
700015004153	flavoprotein, HI0933 family; Region: TIGR00275
700015004154	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
700015004155	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
700015004156	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
700015004157	active site
700015004158	NAD binding site [chemical binding]; other site
700015004159	metal binding site [ion binding]; metal-binding site
700015004160	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
700015004161	intersubunit interface [polypeptide binding]; other site
700015004162	active site
700015004163	Zn2+ binding site [ion binding]; other site
700015004164	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171
700015004165	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
700015004166	putative ligand binding site [chemical binding]; other site
700015004167	putative NAD binding site [chemical binding]; other site
700015004168	catalytic site [active]
700015004169	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
700015004170	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
700015004171	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
700015004172	active site
700015004173	P-loop; other site
700015004174	phosphorylation site [posttranslational modification]
700015004175	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
700015004176	active site
700015004177	phosphorylation site [posttranslational modification]
700015004178	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700015004179	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700015004180	non-specific DNA binding site [nucleotide binding]; other site
700015004181	salt bridge; other site
700015004182	sequence-specific DNA binding site [nucleotide binding]; other site
700015004183	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
700015004184	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
700015004185	dimer interface [polypeptide binding]; other site
700015004186	active site
700015004187	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
700015004188	dimer interface [polypeptide binding]; other site
700015004189	active site
700015004190	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
700015004191	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
700015004192	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
700015004193	active site
700015004194	phosphorylation site [posttranslational modification]
700015004195	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
700015004196	active pocket/dimerization site; other site
700015004197	active site
700015004198	phosphorylation site [posttranslational modification]
700015004199	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
700015004200	non-specific DNA binding site [nucleotide binding]; other site
700015004201	salt bridge; other site
700015004202	sequence-specific DNA binding site [nucleotide binding]; other site
700015004203	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
700015004204	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700015004205	active site
700015004206	catalytic tetrad [active]
700015004207	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
700015004208	RNA/DNA hybrid binding site [nucleotide binding]; other site
700015004209	active site
700015004210	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700015004211	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700015004212	Acylphosphatase; Region: Acylphosphatase; pfam00708
700015004213	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
700015004214	metal binding site 2 [ion binding]; metal-binding site
700015004215	putative DNA binding helix; other site
700015004216	metal binding site 1 [ion binding]; metal-binding site
700015004217	dimer interface [polypeptide binding]; other site
700015004218	structural Zn2+ binding site [ion binding]; other site
700015004219	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
700015004220	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
700015004221	active site
700015004222	HIGH motif; other site
700015004223	dimer interface [polypeptide binding]; other site
700015004224	KMSKS motif; other site
700015004225	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
700015004226	RNA binding surface [nucleotide binding]; other site
700015004227	Transglycosylase; Region: Transgly; pfam00912
700015004228	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
700015004229	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
700015004230	Arginine repressor [Transcription]; Region: ArgR; COG1438
700015004231	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
700015004232	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
700015004233	XFP N-terminal domain; Region: XFP_N; pfam09364
700015004234	putative phosphoketolase; Provisional; Region: PRK05261
700015004235	XFP C-terminal domain; Region: XFP_C; pfam09363
700015004236	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700015004237	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700015004238	DNA binding site [nucleotide binding]
700015004239	domain linker motif; other site
700015004240	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700015004241	dimerization interface [polypeptide binding]; other site
700015004242	ligand binding site [chemical binding]; other site
700015004243	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700015004244	active site
700015004245	Poly A polymerase regulatory subunit; Region: PARP_regulatory; cl03179
700015004246	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
700015004247	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
700015004248	dimerization interface 3.5A [polypeptide binding]; other site
700015004249	active site
700015004250	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
700015004251	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
700015004252	Walker A/P-loop; other site
700015004253	ATP binding site [chemical binding]; other site
700015004254	Q-loop/lid; other site
700015004255	ABC transporter signature motif; other site
700015004256	Walker B; other site
700015004257	D-loop; other site
700015004258	H-loop/switch region; other site
700015004259	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
700015004260	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
700015004261	Walker A/P-loop; other site
700015004262	ATP binding site [chemical binding]; other site
700015004263	Q-loop/lid; other site
700015004264	ABC transporter signature motif; other site
700015004265	Walker B; other site
700015004266	D-loop; other site
700015004267	H-loop/switch region; other site
700015004268	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
700015004269	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
700015004270	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
700015004271	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
700015004272	alphaNTD homodimer interface [polypeptide binding]; other site
700015004273	alphaNTD - beta interaction site [polypeptide binding]; other site
700015004274	alphaNTD - beta' interaction site [polypeptide binding]; other site
700015004275	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
700015004276	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
700015004277	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
700015004278	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
700015004279	RNA binding surface [nucleotide binding]; other site
700015004280	30S ribosomal protein S11; Validated; Region: PRK05309
700015004281	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
700015004282	30S ribosomal protein S13; Region: bact_S13; TIGR03631
700015004283	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
700015004284	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
700015004285	rRNA binding site [nucleotide binding]; other site
700015004286	predicted 30S ribosome binding site; other site
700015004287	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
700015004288	active site
700015004289	adenylate kinase; Reviewed; Region: adk; PRK00279
700015004290	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
700015004291	AMP-binding site [chemical binding]; other site
700015004292	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
700015004293	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
700015004294	SecY translocase; Region: SecY; pfam00344
700015004295	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
700015004296	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
700015004297	23S rRNA binding site [nucleotide binding]; other site
700015004298	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
700015004299	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
700015004300	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
700015004301	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
700015004302	5S rRNA interface [nucleotide binding]; other site
700015004303	23S rRNA interface [nucleotide binding]; other site
700015004304	L27 interface [polypeptide binding]; other site
700015004305	L5 interface [polypeptide binding]; other site
700015004306	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
700015004307	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
700015004308	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
700015004309	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
700015004310	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
700015004311	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
700015004312	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
700015004313	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
700015004314	Membrane transport protein; Region: Mem_trans; cl09117
700015004315	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
700015004316	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
700015004317	RNA binding site [nucleotide binding]; other site
700015004318	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
700015004319	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
700015004320	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
700015004321	23S rRNA interface [nucleotide binding]; other site
700015004322	putative translocon interaction site; other site
700015004323	signal recognition particle (SRP54) interaction site; other site
700015004324	L23 interface [polypeptide binding]; other site
700015004325	trigger factor interaction site; other site
700015004326	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
700015004327	23S rRNA interface [nucleotide binding]; other site
700015004328	5S rRNA interface [nucleotide binding]; other site
700015004329	putative antibiotic binding site [chemical binding]; other site
700015004330	L25 interface [polypeptide binding]; other site
700015004331	L27 interface [polypeptide binding]; other site
700015004332	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
700015004333	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
700015004334	G-X-X-G motif; other site
700015004335	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
700015004336	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
700015004337	putative translocon binding site; other site
700015004338	protein-rRNA interface [nucleotide binding]; other site
700015004339	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
700015004340	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
700015004341	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
700015004342	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
700015004343	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
700015004344	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
700015004345	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
700015004346	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
700015004347	elongation factor G; Reviewed; Region: PRK00007
700015004348	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
700015004349	G1 box; other site
700015004350	putative GEF interaction site [polypeptide binding]; other site
700015004351	GTP/Mg2+ binding site [chemical binding]; other site
700015004352	Switch I region; other site
700015004353	G2 box; other site
700015004354	G3 box; other site
700015004355	Switch II region; other site
700015004356	G4 box; other site
700015004357	G5 box; other site
700015004358	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
700015004359	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
700015004360	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
700015004361	30S ribosomal protein S7; Validated; Region: PRK05302
700015004362	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
700015004363	S17 interaction site [polypeptide binding]; other site
700015004364	S8 interaction site; other site
700015004365	16S rRNA interaction site [nucleotide binding]; other site
700015004366	streptomycin interaction site [chemical binding]; other site
700015004367	23S rRNA interaction site [nucleotide binding]; other site
700015004368	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
700015004369	DNA-directed RNA polymerase subunit beta'/alpha domain fusion protein; Provisional; Region: PRK14906
700015004370	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
700015004371	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
700015004372	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
700015004373	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
700015004374	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
700015004375	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
700015004376	DNA binding site [nucleotide binding]
700015004377	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
700015004378	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
700015004379	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
700015004380	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
700015004381	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
700015004382	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
700015004383	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
700015004384	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
700015004385	RPB1 interaction site [polypeptide binding]; other site
700015004386	RPB10 interaction site [polypeptide binding]; other site
700015004387	RPB11 interaction site [polypeptide binding]; other site
700015004388	RPB3 interaction site [polypeptide binding]; other site
700015004389	RPB12 interaction site [polypeptide binding]; other site
700015004390	Domain of unknown function (DUF362); Region: DUF362; pfam04015
700015004391	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
700015004392	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700015004393	Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862
700015004394	Predicted dehydrogenase [General function prediction only]; Region: COG0579
700015004395	hydroxyglutarate oxidase; Provisional; Region: PRK11728
700015004396	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
700015004397	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700015004398	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
700015004399	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
700015004400	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
700015004401	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
700015004402	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
700015004403	inhibitor site; inhibition site
700015004404	active site
700015004405	dimer interface [polypeptide binding]; other site
700015004406	catalytic residue [active]
700015004407	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
700015004408	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
700015004409	active site
700015004410	tetramer interface [polypeptide binding]; other site
700015004411	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
700015004412	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
700015004413	metal binding site [ion binding]; metal-binding site
700015004414	substrate binding pocket [chemical binding]; other site
700015004415	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
700015004416	Citrate transporter; Region: CitMHS; pfam03600
700015004417	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
700015004418	galactarate dehydratase; Region: galactar-dH20; TIGR03248
700015004419	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
700015004420	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
700015004421	Coenzyme A binding pocket [chemical binding]; other site
700015004422	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
700015004423	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
700015004424	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
700015004425	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
700015004426	active site
700015004427	tetramer interface; other site
700015004428	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
700015004429	core dimer interface [polypeptide binding]; other site
700015004430	peripheral dimer interface [polypeptide binding]; other site
700015004431	L10 interface [polypeptide binding]; other site
700015004432	L11 interface [polypeptide binding]; other site
700015004433	putative EF-Tu interaction site [polypeptide binding]; other site
700015004434	putative EF-G interaction site [polypeptide binding]; other site
700015004435	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
700015004436	23S rRNA interface [nucleotide binding]; other site
700015004437	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
700015004438	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700015004439	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700015004440	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015004441	Walker A/P-loop; other site
700015004442	ATP binding site [chemical binding]; other site
700015004443	Q-loop/lid; other site
700015004444	ABC transporter signature motif; other site
700015004445	Walker B; other site
700015004446	D-loop; other site
700015004447	H-loop/switch region; other site
700015004448	amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924
700015004449	POT family; Region: PTR2; cl17359
700015004450	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700015004451	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700015004452	non-specific DNA binding site [nucleotide binding]; other site
700015004453	salt bridge; other site
700015004454	sequence-specific DNA binding site [nucleotide binding]; other site
700015004455	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
700015004456	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
700015004457	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
700015004458	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
700015004459	putative active site [active]
700015004460	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700015004461	dimerization interface [polypeptide binding]; other site
700015004462	putative DNA binding site [nucleotide binding]; other site
700015004463	putative Zn2+ binding site [ion binding]; other site
700015004464	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
700015004465	SdpI/YhfL protein family; Region: SdpI; pfam13630
700015004466	FeoA domain; Region: FeoA; pfam04023
700015004467	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
700015004468	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
700015004469	G1 box; other site
700015004470	GTP/Mg2+ binding site [chemical binding]; other site
700015004471	Switch I region; other site
700015004472	G2 box; other site
700015004473	G3 box; other site
700015004474	Switch II region; other site
700015004475	G4 box; other site
700015004476	G5 box; other site
700015004477	Nucleoside recognition; Region: Gate; pfam07670
700015004478	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
700015004479	Nucleoside recognition; Region: Gate; pfam07670
700015004480	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
700015004481	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700015004482	motif II; other site
700015004483	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
700015004484	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
700015004485	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015004486	Walker A/P-loop; other site
700015004487	ATP binding site [chemical binding]; other site
700015004488	Q-loop/lid; other site
700015004489	ABC transporter signature motif; other site
700015004490	Walker B; other site
700015004491	D-loop; other site
700015004492	H-loop/switch region; other site
700015004493	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
700015004494	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
700015004495	TM-ABC transporter signature motif; other site
700015004496	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
700015004497	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
700015004498	zinc binding site [ion binding]; other site
700015004499	putative ligand binding site [chemical binding]; other site
700015004500	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
700015004501	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
700015004502	putative dimer interface [polypeptide binding]; other site
700015004503	putative anticodon binding site; other site
700015004504	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
700015004505	motif 1; other site
700015004506	dimer interface [polypeptide binding]; other site
700015004507	active site
700015004508	motif 2; other site
700015004509	motif 3; other site
700015004510	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
700015004511	mRNA/rRNA interface [nucleotide binding]; other site
700015004512	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
700015004513	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
700015004514	23S rRNA interface [nucleotide binding]; other site
700015004515	L7/L12 interface [polypeptide binding]; other site
700015004516	putative thiostrepton binding site; other site
700015004517	L25 interface [polypeptide binding]; other site
700015004518	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
700015004519	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
700015004520	putative homodimer interface [polypeptide binding]; other site
700015004521	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
700015004522	heterodimer interface [polypeptide binding]; other site
700015004523	homodimer interface [polypeptide binding]; other site
700015004524	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
700015004525	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
700015004526	elongation factor Tu; Reviewed; Region: PRK00049
700015004527	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
700015004528	G1 box; other site
700015004529	GEF interaction site [polypeptide binding]; other site
700015004530	GTP/Mg2+ binding site [chemical binding]; other site
700015004531	Switch I region; other site
700015004532	G2 box; other site
700015004533	G3 box; other site
700015004534	Switch II region; other site
700015004535	G4 box; other site
700015004536	G5 box; other site
700015004537	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
700015004538	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
700015004539	Antibiotic Binding Site [chemical binding]; other site
700015004540	YacP-like NYN domain; Region: NYN_YacP; pfam05991
700015004541	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
700015004542	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
700015004543	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
700015004544	Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: CysS; COG0215
700015004545	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
700015004546	active site
700015004547	HIGH motif; other site
700015004548	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
700015004549	KMSKS motif; other site
700015004550	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
700015004551	tRNA binding surface [nucleotide binding]; other site
700015004552	anticodon binding site; other site
700015004553	DALR domain; Region: DALR_2; pfam09190
700015004554	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
700015004555	homotrimer interaction site [polypeptide binding]; other site
700015004556	zinc binding site [ion binding]; other site
700015004557	CDP-binding sites; other site
700015004558	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
700015004559	substrate binding site; other site
700015004560	dimer interface; other site
700015004561	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
700015004562	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
700015004563	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
700015004564	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
700015004565	Clp amino terminal domain; Region: Clp_N; pfam02861
700015004566	Clp amino terminal domain; Region: Clp_N; pfam02861
700015004567	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700015004568	Walker A motif; other site
700015004569	ATP binding site [chemical binding]; other site
700015004570	Walker B motif; other site
700015004571	arginine finger; other site
700015004572	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700015004573	Walker A motif; other site
700015004574	ATP binding site [chemical binding]; other site
700015004575	Walker B motif; other site
700015004576	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
700015004577	MFS/sugar transport protein; Region: MFS_2; pfam13347
700015004578	Melibiase; Region: Melibiase; pfam02065
700015004579	MFS/sugar transport protein; Region: MFS_2; pfam13347
700015004580	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
700015004581	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700015004582	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700015004583	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700015004584	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700015004585	DNA binding site [nucleotide binding]
700015004586	domain linker motif; other site
700015004587	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700015004588	dimerization interface [polypeptide binding]; other site
700015004589	ligand binding site [chemical binding]; other site
700015004590	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
700015004591	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
700015004592	substrate binding site [chemical binding]; other site
700015004593	dimer interface [polypeptide binding]; other site
700015004594	ATP binding site [chemical binding]; other site
700015004595	MFS/sugar transport protein; Region: MFS_2; pfam13347
700015004596	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
700015004597	active site
700015004598	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
700015004599	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
700015004600	active site
700015004601	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
700015004602	Protein of unknown function, DUF606; Region: DUF606; pfam04657
700015004603	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
700015004604	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
700015004605	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
700015004606	dimer interface [polypeptide binding]; other site
700015004607	putative anticodon binding site; other site
700015004608	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
700015004609	motif 1; other site
700015004610	active site
700015004611	motif 2; other site
700015004612	motif 3; other site
700015004613	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
700015004614	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
700015004615	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
700015004616	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
700015004617	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609
700015004618	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
700015004619	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
700015004620	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
700015004621	active site
700015004622	dimerization interface [polypeptide binding]; other site
700015004623	ribonuclease PH; Reviewed; Region: rph; PRK00173
700015004624	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
700015004625	oligomer interface [polypeptide binding]; other site
700015004626	RNA binding site [nucleotide binding]; other site
700015004627	glutamate racemase; Provisional; Region: PRK00865
700015004628	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
700015004629	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700015004630	active site
700015004631	motif I; other site
700015004632	motif II; other site
700015004633	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
700015004634	endonuclease subunit; Provisional; Region: 47; PHA02546
700015004635	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
700015004636	acetylornithine aminotransferase; Provisional; Region: PRK02627
700015004637	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700015004638	inhibitor-cofactor binding pocket; inhibition site
700015004639	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700015004640	catalytic residue [active]
700015004641	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
700015004642	homohexameric interface [polypeptide binding]; other site
700015004643	feedback inhibition sensing region; other site
700015004644	nucleotide binding site [chemical binding]; other site
700015004645	N-acetyl-L-glutamate binding site [chemical binding]; other site
700015004646	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
700015004647	heterotetramer interface [polypeptide binding]; other site
700015004648	active site pocket [active]
700015004649	cleavage site
700015004650	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
700015004651	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
700015004652	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
700015004653	NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179
700015004654	putative active site [active]
700015004655	metal binding site [ion binding]; metal-binding site
700015004656	Protein of unknown function (DUF3781); Region: DUF3781; pfam12636
700015004657	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700015004658	Coenzyme A binding pocket [chemical binding]; other site
700015004659	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
700015004660	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
700015004661	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
700015004662	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
700015004663	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
700015004664	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
700015004665	Bacterial transcriptional activator domain; Region: BTAD; smart01043
700015004666	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
700015004667	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
700015004668	active site
700015004669	trimer interface [polypeptide binding]; other site
700015004670	allosteric site; other site
700015004671	active site lid [active]
700015004672	hexamer (dimer of trimers) interface [polypeptide binding]; other site
700015004673	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
700015004674	HPr interaction site; other site
700015004675	glycerol kinase (GK) interaction site [polypeptide binding]; other site
700015004676	active site
700015004677	phosphorylation site [posttranslational modification]
700015004678	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
700015004679	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
700015004680	active site
700015004681	substrate binding site [chemical binding]; other site
700015004682	metal binding site [ion binding]; metal-binding site
700015004683	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
700015004684	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
700015004685	23S rRNA interface [nucleotide binding]; other site
700015004686	L3 interface [polypeptide binding]; other site
700015004687	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
700015004688	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
700015004689	active site
700015004690	nucleophile elbow; other site
700015004691	endonuclease subunit; Provisional; Region: 46; PHA02562
700015004692	NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285
700015004693	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
700015004694	tetramer interface [polypeptide binding]; other site
700015004695	catalytic Zn binding site [ion binding]; other site
700015004696	NADP binding site [chemical binding]; other site
700015004697	Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064
700015004698	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
700015004699	GatB domain; Region: GatB_Yqey; smart00845
700015004700	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
700015004701	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
700015004702	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
700015004703	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
700015004704	catalytic core [active]
700015004705	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
700015004706	dimerization domain swap beta strand [polypeptide binding]; other site
700015004707	regulatory protein interface [polypeptide binding]; other site
700015004708	active site
700015004709	regulatory phosphorylation site [posttranslational modification]; other site
700015004710	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
700015004711	HPr interaction site; other site
700015004712	glycerol kinase (GK) interaction site [polypeptide binding]; other site
700015004713	active site
700015004714	phosphorylation site [posttranslational modification]
700015004715	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
700015004716	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
700015004717	active site turn [active]
700015004718	phosphorylation site [posttranslational modification]
700015004719	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
700015004720	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
700015004721	beta-galactosidase; Region: BGL; TIGR03356
700015004722	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
700015004723	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
700015004724	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
700015004725	active site
700015004726	P-loop; other site
700015004727	phosphorylation site [posttranslational modification]
700015004728	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
700015004729	active site
700015004730	methionine cluster; other site
700015004731	phosphorylation site [posttranslational modification]
700015004732	metal binding site [ion binding]; metal-binding site
700015004733	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
700015004734	Mga helix-turn-helix domain; Region: Mga; pfam05043
700015004735	PRD domain; Region: PRD; pfam00874
700015004736	PRD domain; Region: PRD; pfam00874
700015004737	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
700015004738	active site
700015004739	P-loop; other site
700015004740	phosphorylation site [posttranslational modification]
700015004741	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
700015004742	active site
700015004743	phosphorylation site [posttranslational modification]
700015004744	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
700015004745	beta-galactosidase; Region: BGL; TIGR03356
700015004746	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
700015004747	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
700015004748	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
700015004749	putative active site [active]
700015004750	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700015004751	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700015004752	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
700015004753	Walker A/P-loop; other site
700015004754	ATP binding site [chemical binding]; other site
700015004755	Q-loop/lid; other site
700015004756	ABC transporter signature motif; other site
700015004757	Walker B; other site
700015004758	D-loop; other site
700015004759	H-loop/switch region; other site
700015004760	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700015004761	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700015004762	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015004763	Walker A/P-loop; other site
700015004764	ATP binding site [chemical binding]; other site
700015004765	Q-loop/lid; other site
700015004766	ABC transporter signature motif; other site
700015004767	Walker B; other site
700015004768	D-loop; other site
700015004769	H-loop/switch region; other site
700015004770	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
700015004771	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
700015004772	nucleotide binding pocket [chemical binding]; other site
700015004773	K-X-D-G motif; other site
700015004774	catalytic site [active]
700015004775	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
700015004776	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
700015004777	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
700015004778	Dimer interface [polypeptide binding]; other site
700015004779	BRCT sequence motif; other site
700015004780	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
700015004781	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
700015004782	protein binding site [polypeptide binding]; other site
700015004783	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700015004784	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700015004785	DNA binding site [nucleotide binding]
700015004786	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
700015004787	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
700015004788	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
700015004789	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
700015004790	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
700015004791	G1 box; other site
700015004792	GTP/Mg2+ binding site [chemical binding]; other site
700015004793	Switch I region; other site
700015004794	G2 box; other site
700015004795	G3 box; other site
700015004796	Switch II region; other site
700015004797	G4 box; other site
700015004798	G5 box; other site
700015004799	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
700015004800	Nucleoside recognition; Region: Gate; pfam07670
700015004801	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
700015004802	Nucleoside recognition; Region: Gate; pfam07670
700015004803	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
700015004804	FeoA domain; Region: FeoA; pfam04023
700015004805	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
700015004806	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
700015004807	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
700015004808	dimer interface [polypeptide binding]; other site
700015004809	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
700015004810	anticodon binding site; other site
700015004811	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
700015004812	motif 1; other site
700015004813	dimer interface [polypeptide binding]; other site
700015004814	active site
700015004815	motif 2; other site
700015004816	GAD domain; Region: GAD; pfam02938
700015004817	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
700015004818	active site
700015004819	motif 3; other site
700015004820	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
700015004821	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
700015004822	substrate binding pocket [chemical binding]; other site
700015004823	membrane-bound complex binding site; other site
700015004824	hinge residues; other site
700015004825	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
700015004826	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700015004827	dimer interface [polypeptide binding]; other site
700015004828	conserved gate region; other site
700015004829	putative PBP binding loops; other site
700015004830	ABC-ATPase subunit interface; other site
700015004831	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
700015004832	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
700015004833	Walker A/P-loop; other site
700015004834	ATP binding site [chemical binding]; other site
700015004835	Q-loop/lid; other site
700015004836	ABC transporter signature motif; other site
700015004837	Walker B; other site
700015004838	D-loop; other site
700015004839	H-loop/switch region; other site
700015004840	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700015004841	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
700015004842	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700015004843	substrate binding pocket [chemical binding]; other site
700015004844	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
700015004845	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
700015004846	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
700015004847	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
700015004848	dimer interface [polypeptide binding]; other site
700015004849	motif 1; other site
700015004850	active site
700015004851	motif 2; other site
700015004852	motif 3; other site
700015004853	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
700015004854	anticodon binding site; other site
700015004855	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
700015004856	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
700015004857	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
700015004858	anti sigma factor interaction site; other site
700015004859	regulatory phosphorylation site [posttranslational modification]; other site
700015004860	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
700015004861	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700015004862	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700015004863	homodimer interface [polypeptide binding]; other site
700015004864	catalytic residue [active]
700015004865	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
700015004866	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
700015004867	nucleotide binding site [chemical binding]; other site
700015004868	methionine cluster; other site
700015004869	PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255
700015004870	active site
700015004871	phosphorylation site [posttranslational modification]
700015004872	metal binding site [ion binding]; metal-binding site
700015004873	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
700015004874	active site
700015004875	P-loop; other site
700015004876	phosphorylation site [posttranslational modification]
700015004877	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
700015004878	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
700015004879	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
700015004880	beta-galactosidase; Region: BGL; TIGR03356
700015004881	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
700015004882	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700015004883	DNA-binding site [nucleotide binding]; DNA binding site
700015004884	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
700015004885	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
700015004886	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
700015004887	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
700015004888	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015004889	Walker A/P-loop; other site
700015004890	ATP binding site [chemical binding]; other site
700015004891	Q-loop/lid; other site
700015004892	ABC transporter signature motif; other site
700015004893	Walker B; other site
700015004894	D-loop; other site
700015004895	H-loop/switch region; other site
700015004896	Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224
700015004897	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700015004898	dimerization interface [polypeptide binding]; other site
700015004899	putative DNA binding site [nucleotide binding]; other site
700015004900	putative Zn2+ binding site [ion binding]; other site
700015004901	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700015004902	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700015004903	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700015004904	Walker A/P-loop; other site
700015004905	ATP binding site [chemical binding]; other site
700015004906	Q-loop/lid; other site
700015004907	ABC transporter signature motif; other site
700015004908	Walker B; other site
700015004909	D-loop; other site
700015004910	H-loop/switch region; other site
700015004911	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
700015004912	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
700015004913	putative tRNA-binding site [nucleotide binding]; other site
700015004914	B3/4 domain; Region: B3_4; pfam03483
700015004915	tRNA synthetase B5 domain; Region: B5; smart00874
700015004916	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
700015004917	dimer interface [polypeptide binding]; other site
700015004918	motif 1; other site
700015004919	motif 3; other site
700015004920	motif 2; other site
700015004921	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
700015004922	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
700015004923	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
700015004924	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
700015004925	dimer interface [polypeptide binding]; other site
700015004926	motif 1; other site
700015004927	active site
700015004928	motif 2; other site
700015004929	motif 3; other site
700015004930	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
700015004931	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
700015004932	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
700015004933	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
700015004934	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
700015004935	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700015004936	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
700015004937	active site
700015004938	catalytic tetrad [active]
700015004939	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
700015004940	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
700015004941	substrate binding site [chemical binding]; other site
700015004942	ATP binding site [chemical binding]; other site
700015004943	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
700015004944	intersubunit interface [polypeptide binding]; other site
700015004945	active site
700015004946	zinc binding site [ion binding]; other site
700015004947	Na+ binding site [ion binding]; other site
700015004948	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
700015004949	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
700015004950	inhibitor binding site; inhibition site
700015004951	catalytic Zn binding site [ion binding]; other site
700015004952	structural Zn binding site [ion binding]; other site
700015004953	NADP binding site [chemical binding]; other site
700015004954	tetramer interface [polypeptide binding]; other site
700015004955	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015004956	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700015004957	putative substrate translocation pore; other site
700015004958	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015004959	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
700015004960	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
700015004961	putative NAD(P) binding site [chemical binding]; other site
700015004962	catalytic Zn binding site [ion binding]; other site
700015004963	structural Zn binding site [ion binding]; other site
700015004964	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
700015004965	D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205
700015004966	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700015004967	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
700015004968	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700015004969	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700015004970	homodimer interface [polypeptide binding]; other site
700015004971	catalytic residue [active]
700015004972	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
700015004973	active site
700015004974	Zn binding site [ion binding]; other site
700015004975	EamA-like transporter family; Region: EamA; pfam00892
700015004976	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
700015004977	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
700015004978	Peptidase M16C associated; Region: M16C_assoc; pfam08367
700015004979	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700015004980	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700015004981	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
700015004982	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700015004983	ATP binding site [chemical binding]; other site
700015004984	putative Mg++ binding site [ion binding]; other site
700015004985	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700015004986	nucleotide binding region [chemical binding]; other site
700015004987	ATP-binding site [chemical binding]; other site
700015004988	RQC domain; Region: RQC; pfam09382
700015004989	HRDC domain; Region: HRDC; pfam00570
700015004990	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
700015004991	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
700015004992	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
700015004993	Walker A/P-loop; other site
700015004994	ATP binding site [chemical binding]; other site
700015004995	Q-loop/lid; other site
700015004996	ABC transporter signature motif; other site
700015004997	Walker B; other site
700015004998	D-loop; other site
700015004999	H-loop/switch region; other site
700015005000	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
700015005001	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
700015005002	DRTGG domain; Region: DRTGG; pfam07085
700015005003	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
700015005004	DHHA2 domain; Region: DHHA2; pfam02833
700015005005	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
700015005006	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
700015005007	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700015005008	ATP binding site [chemical binding]; other site
700015005009	putative Mg++ binding site [ion binding]; other site
700015005010	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700015005011	nucleotide binding region [chemical binding]; other site
700015005012	ATP-binding site [chemical binding]; other site
700015005013	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
700015005014	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
700015005015	LDH/MDH dimer interface [polypeptide binding]; other site
700015005016	NAD(P) binding site [chemical binding]; other site
700015005017	substrate binding site [chemical binding]; other site
700015005018	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
700015005019	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
700015005020	Walker A/P-loop; other site
700015005021	ATP binding site [chemical binding]; other site
700015005022	Q-loop/lid; other site
700015005023	ABC transporter signature motif; other site
700015005024	Walker B; other site
700015005025	D-loop; other site
700015005026	H-loop/switch region; other site
700015005027	FtsX-like permease family; Region: FtsX; pfam02687
700015005028	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
700015005029	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
700015005030	Walker A/P-loop; other site
700015005031	ATP binding site [chemical binding]; other site
700015005032	Q-loop/lid; other site
700015005033	ABC transporter signature motif; other site
700015005034	Walker B; other site
700015005035	D-loop; other site
700015005036	H-loop/switch region; other site
700015005037	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700015005038	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700015005039	active site
700015005040	phosphorylation site [posttranslational modification]
700015005041	intermolecular recognition site; other site
700015005042	dimerization interface [polypeptide binding]; other site
700015005043	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700015005044	DNA binding site [nucleotide binding]
700015005045	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700015005046	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700015005047	dimerization interface [polypeptide binding]; other site
700015005048	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700015005049	dimer interface [polypeptide binding]; other site
700015005050	phosphorylation site [posttranslational modification]
700015005051	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700015005052	ATP binding site [chemical binding]; other site
700015005053	Mg2+ binding site [ion binding]; other site
700015005054	G-X-G motif; other site
700015005055	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
700015005056	MgtC family; Region: MgtC; pfam02308
700015005057	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
700015005058	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
700015005059	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
700015005060	putative active site [active]
700015005061	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
700015005062	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
700015005063	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
700015005064	active site
700015005065	P-loop; other site
700015005066	phosphorylation site [posttranslational modification]
700015005067	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
700015005068	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
700015005069	active site
700015005070	phosphorylation site [posttranslational modification]
700015005071	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
700015005072	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
700015005073	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
700015005074	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
700015005075	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
700015005076	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
700015005077	ABC-ATPase subunit  interface; other site
700015005078	dimer interface [polypeptide binding]; other site
700015005079	putative PBP binding regions; other site
700015005080	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
700015005081	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
700015005082	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
700015005083	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
700015005084	intersubunit interface [polypeptide binding]; other site
700015005085	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
700015005086	metal binding site 2 [ion binding]; metal-binding site
700015005087	putative DNA binding helix; other site
700015005088	metal binding site 1 [ion binding]; metal-binding site
700015005089	dimer interface [polypeptide binding]; other site
700015005090	structural Zn2+ binding site [ion binding]; other site
700015005091	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
700015005092	Double zinc ribbon; Region: DZR; pfam12773
700015005093	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
700015005094	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
700015005095	Double zinc ribbon; Region: DZR; pfam12773
700015005096	YARHG domain; Region: YARHG; pfam13308
700015005097	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
700015005098	amidase catalytic site [active]
700015005099	Zn binding residues [ion binding]; other site
700015005100	substrate binding site [chemical binding]; other site
700015005101	Double zinc ribbon; Region: DZR; pfam12773
700015005102	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
700015005103	Protein of unknown function (DUF4013); Region: DUF4013; pfam13197
700015005104	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
700015005105	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
700015005106	DNA binding site [nucleotide binding]
700015005107	substrate interaction site [chemical binding]; other site
700015005108	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
700015005109	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
700015005110	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
700015005111	PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825
700015005112	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
700015005113	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608
700015005114	Glucitol operon activator protein (GutM); Region: GutM; pfam06923
700015005115	HTH domain; Region: HTH_11; pfam08279
700015005116	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
700015005117	PRD domain; Region: PRD; pfam00874
700015005118	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
700015005119	active site
700015005120	phosphorylation site [posttranslational modification]
700015005121	sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171
700015005122	classical (c) SDRs; Region: SDR_c; cd05233
700015005123	NAD(P) binding site [chemical binding]; other site
700015005124	active site
700015005125	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
700015005126	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
700015005127	active site
700015005128	phosphorylation site [posttranslational modification]
700015005129	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
700015005130	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
700015005131	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
700015005132	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700015005133	DNA-binding site [nucleotide binding]; DNA binding site
700015005134	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
700015005135	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700015005136	dimer interface [polypeptide binding]; other site
700015005137	phosphorylation site [posttranslational modification]
700015005138	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700015005139	ATP binding site [chemical binding]; other site
700015005140	Mg2+ binding site [ion binding]; other site
700015005141	G-X-G motif; other site
700015005142	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700015005143	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700015005144	active site
700015005145	phosphorylation site [posttranslational modification]
700015005146	intermolecular recognition site; other site
700015005147	dimerization interface [polypeptide binding]; other site
700015005148	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700015005149	DNA binding site [nucleotide binding]
700015005150	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
700015005151	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
700015005152	active site
700015005153	intersubunit interface [polypeptide binding]; other site
700015005154	catalytic residue [active]
700015005155	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
700015005156	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
700015005157	inhibitor site; inhibition site
700015005158	active site
700015005159	dimer interface [polypeptide binding]; other site
700015005160	catalytic residue [active]
700015005161	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
700015005162	active pocket/dimerization site; other site
700015005163	active site
700015005164	phosphorylation site [posttranslational modification]
700015005165	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
700015005166	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172
700015005167	putative ligand binding site [chemical binding]; other site
700015005168	putative NAD binding site [chemical binding]; other site
700015005169	catalytic site [active]
700015005170	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
700015005171	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
700015005172	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
700015005173	active site
700015005174	phosphorylation site [posttranslational modification]
700015005175	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
700015005176	putative active site [active]
700015005177	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700015005178	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700015005179	DNA binding site [nucleotide binding]
700015005180	domain linker motif; other site
700015005181	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700015005182	dimerization interface [polypeptide binding]; other site
700015005183	ligand binding site [chemical binding]; other site
700015005184	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
700015005185	G1 box; other site
700015005186	GTP/Mg2+ binding site [chemical binding]; other site
700015005187	Switch I region; other site
700015005188	G2 box; other site
700015005189	G3 box; other site
700015005190	Switch II region; other site
700015005191	G4 box; other site
700015005192	G5 box; other site
700015005193	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
700015005194	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
700015005195	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
700015005196	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
700015005197	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
700015005198	putative active site [active]
700015005199	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
700015005200	intersubunit interface [polypeptide binding]; other site
700015005201	active site
700015005202	zinc binding site [ion binding]; other site
700015005203	Na+ binding site [ion binding]; other site
700015005204	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
700015005205	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
700015005206	active site
700015005207	P-loop; other site
700015005208	phosphorylation site [posttranslational modification]
700015005209	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
700015005210	active site
700015005211	phosphorylation site [posttranslational modification]
700015005212	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
700015005213	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
700015005214	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
700015005215	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015005216	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
700015005217	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
700015005218	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700015005219	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700015005220	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700015005221	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
700015005222	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
700015005223	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
700015005224	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
700015005225	nucleotide binding site [chemical binding]; other site
700015005226	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
700015005227	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
700015005228	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
700015005229	NAD binding site [chemical binding]; other site
700015005230	sugar binding site [chemical binding]; other site
700015005231	divalent metal binding site [ion binding]; other site
700015005232	tetramer (dimer of dimers) interface [polypeptide binding]; other site
700015005233	dimer interface [polypeptide binding]; other site
700015005234	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
700015005235	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
700015005236	beta-galactosidase; Region: BGL; TIGR03356
700015005237	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
700015005238	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
700015005239	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
700015005240	active site
700015005241	P-loop; other site
700015005242	phosphorylation site [posttranslational modification]
700015005243	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
700015005244	active site
700015005245	methionine cluster; other site
700015005246	phosphorylation site [posttranslational modification]
700015005247	metal binding site [ion binding]; metal-binding site
700015005248	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
700015005249	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
700015005250	Mga helix-turn-helix domain; Region: Mga; pfam05043
700015005251	PRD domain; Region: PRD; pfam00874
700015005252	PRD domain; Region: PRD; pfam00874
700015005253	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
700015005254	active site
700015005255	P-loop; other site
700015005256	phosphorylation site [posttranslational modification]
700015005257	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
700015005258	active site
700015005259	phosphorylation site [posttranslational modification]
700015005260	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
700015005261	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700015005262	FeS/SAM binding site; other site
700015005263	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
700015005264	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
700015005265	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
700015005266	FtsX-like permease family; Region: FtsX; pfam02687
700015005267	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
700015005268	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
700015005269	Walker A/P-loop; other site
700015005270	ATP binding site [chemical binding]; other site
700015005271	Q-loop/lid; other site
700015005272	ABC transporter signature motif; other site
700015005273	Walker B; other site
700015005274	D-loop; other site
700015005275	H-loop/switch region; other site
700015005276	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
700015005277	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
700015005278	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
700015005279	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
700015005280	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
700015005281	Walker A/P-loop; other site
700015005282	ATP binding site [chemical binding]; other site
700015005283	Q-loop/lid; other site
700015005284	ABC transporter signature motif; other site
700015005285	Walker B; other site
700015005286	D-loop; other site
700015005287	H-loop/switch region; other site
700015005288	putrescine carbamoyltransferase; Provisional; Region: PRK02255
700015005289	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
700015005290	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
700015005291	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
700015005292	active site
700015005293	8-oxo-dGMP binding site [chemical binding]; other site
700015005294	nudix motif; other site
700015005295	metal binding site [ion binding]; metal-binding site
700015005296	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
700015005297	additional DNA contacts [nucleotide binding]; other site
700015005298	mismatch recognition site; other site
700015005299	active site
700015005300	zinc binding site [ion binding]; other site
700015005301	DNA intercalation site [nucleotide binding]; other site
700015005302	Predicted membrane protein [Function unknown]; Region: COG1511
700015005303	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
700015005304	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
700015005305	Predicted membrane protein [Function unknown]; Region: COG1511
700015005306	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
700015005307	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
700015005308	heat shock protein 90; Provisional; Region: PRK05218
700015005309	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700015005310	ATP binding site [chemical binding]; other site
700015005311	Mg2+ binding site [ion binding]; other site
700015005312	G-X-G motif; other site
700015005313	Regulator of G protein signaling (RGS) domain superfamily; Region: RGS; cl02565
700015005314	RmuC family; Region: RmuC; pfam02646
700015005315	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
700015005316	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
700015005317	minor groove reading motif; other site
700015005318	helix-hairpin-helix signature motif; other site
700015005319	substrate binding pocket [chemical binding]; other site
700015005320	active site
700015005321	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
700015005322	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
700015005323	LabA_like proteins; Region: LabA_like/DUF88; cl10034
700015005324	putative metal binding site [ion binding]; other site
700015005325	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
700015005326	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
700015005327	active site turn [active]
700015005328	phosphorylation site [posttranslational modification]
700015005329	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
700015005330	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
700015005331	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
700015005332	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
700015005333	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
700015005334	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015005335	putative substrate translocation pore; other site
700015005336	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700015005337	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700015005338	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700015005339	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
700015005340	beta-galactosidase; Region: BGL; TIGR03356
700015005341	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
700015005342	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
700015005343	nucleotide binding site [chemical binding]; other site
700015005344	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
700015005345	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015005346	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700015005347	putative substrate translocation pore; other site
700015005348	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700015005349	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
700015005350	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
700015005351	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
700015005352	catalytic triad [active]
700015005353	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015005354	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700015005355	putative substrate translocation pore; other site
700015005356	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
700015005357	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
700015005358	nucleotide binding site [chemical binding]; other site
700015005359	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
700015005360	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
700015005361	PYR/PP interface [polypeptide binding]; other site
700015005362	dimer interface [polypeptide binding]; other site
700015005363	TPP binding site [chemical binding]; other site
700015005364	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
700015005365	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
700015005366	transketolase; Reviewed; Region: PRK05899
700015005367	TPP-binding site [chemical binding]; other site
700015005368	dimer interface [polypeptide binding]; other site
700015005369	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
700015005370	hexamer (dimer of trimers) interface [polypeptide binding]; other site
700015005371	trimer interface [polypeptide binding]; other site
700015005372	substrate binding site [chemical binding]; other site
700015005373	Mn binding site [ion binding]; other site
700015005374	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
700015005375	active site
700015005376	P-loop; other site
700015005377	phosphorylation site [posttranslational modification]
700015005378	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
700015005379	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
700015005380	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
700015005381	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700015005382	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700015005383	DNA binding site [nucleotide binding]
700015005384	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700015005385	ligand binding site [chemical binding]; other site
700015005386	dimerization interface [polypeptide binding]; other site
700015005387	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700015005388	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700015005389	DNA binding site [nucleotide binding]
700015005390	domain linker motif; other site
700015005391	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700015005392	ligand binding site [chemical binding]; other site
700015005393	dimerization interface [polypeptide binding]; other site
700015005394	Rubrerythrin [Energy production and conversion]; Region: COG1592
700015005395	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
700015005396	binuclear metal center [ion binding]; other site
700015005397	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
700015005398	iron binding site [ion binding]; other site
700015005399	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
700015005400	endonuclease III; Region: ENDO3c; smart00478
700015005401	minor groove reading motif; other site
700015005402	helix-hairpin-helix signature motif; other site
700015005403	substrate binding pocket [chemical binding]; other site
700015005404	active site
700015005405	Rrf2 family protein; Region: rrf2_super; TIGR00738
700015005406	Transcriptional regulator; Region: Rrf2; pfam02082
700015005407	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
700015005408	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700015005409	Coenzyme A binding pocket [chemical binding]; other site
700015005410	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
700015005411	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
700015005412	active site
700015005413	metal binding site [ion binding]; metal-binding site
700015005414	homotetramer interface [polypeptide binding]; other site
700015005415	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700015005416	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700015005417	active site
700015005418	phosphorylation site [posttranslational modification]
700015005419	intermolecular recognition site; other site
700015005420	dimerization interface [polypeptide binding]; other site
700015005421	LytTr DNA-binding domain; Region: LytTR; smart00850
700015005422	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
700015005423	Histidine kinase; Region: His_kinase; pfam06580
700015005424	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700015005425	ATP binding site [chemical binding]; other site
700015005426	Mg2+ binding site [ion binding]; other site
700015005427	G-X-G motif; other site
700015005428	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
700015005429	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
700015005430	QueT transporter; Region: QueT; pfam06177
700015005431	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
700015005432	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
700015005433	putative active site [active]
700015005434	carbamate kinase; Reviewed; Region: PRK12686
700015005435	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
700015005436	putative substrate binding site [chemical binding]; other site
700015005437	nucleotide binding site [chemical binding]; other site
700015005438	nucleotide binding site [chemical binding]; other site
700015005439	homodimer interface [polypeptide binding]; other site
700015005440	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
700015005441	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
700015005442	membrane protein FdrA; Validated; Region: PRK06091
700015005443	CoA binding domain; Region: CoA_binding; pfam02629
700015005444	CoA-ligase; Region: Ligase_CoA; pfam00549
700015005445	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
700015005446	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
700015005447	allantoate amidohydrolase; Region: AllC; TIGR03176
700015005448	active site
700015005449	metal binding site [ion binding]; metal-binding site
700015005450	dimer interface [polypeptide binding]; other site
700015005451	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
700015005452	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
700015005453	Na binding site [ion binding]; other site
700015005454	putative substrate binding site [chemical binding]; other site
700015005455	allantoinase; Provisional; Region: PRK08044
700015005456	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
700015005457	active site
700015005458	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015005459	putative substrate translocation pore; other site
700015005460	D-galactonate transporter; Region: 2A0114; TIGR00893
700015005461	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015005462	D-galactonate transporter; Region: 2A0114; TIGR00893
700015005463	putative substrate translocation pore; other site
700015005464	putative allantoin catabolism protein; Region: ura-cupin; TIGR03214
700015005465	Cupin domain; Region: Cupin_2; cl17218
700015005466	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
700015005467	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
700015005468	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
700015005469	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
700015005470	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_1; cd12161
700015005471	putative ligand binding site [chemical binding]; other site
700015005472	putative NAD binding site [chemical binding]; other site
700015005473	catalytic site [active]
700015005474	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
700015005475	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
700015005476	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
700015005477	dimer interface [polypeptide binding]; other site
700015005478	active site
700015005479	metal binding site [ion binding]; metal-binding site
700015005480	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
700015005481	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
700015005482	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
700015005483	dimer interface [polypeptide binding]; other site
700015005484	PYR/PP interface [polypeptide binding]; other site
700015005485	TPP binding site [chemical binding]; other site
700015005486	substrate binding site [chemical binding]; other site
700015005487	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
700015005488	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
700015005489	Domain of unknown function; Region: EKR; pfam10371
700015005490	4Fe-4S binding domain; Region: Fer4_6; pfam12837
700015005491	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
700015005492	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
700015005493	TPP-binding site [chemical binding]; other site
700015005494	dimer interface [polypeptide binding]; other site
700015005495	recombination protein RecR; Reviewed; Region: recR; PRK00076
700015005496	RecR protein; Region: RecR; pfam02132
700015005497	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
700015005498	putative active site [active]
700015005499	putative metal-binding site [ion binding]; other site
700015005500	tetramer interface [polypeptide binding]; other site
700015005501	hypothetical protein; Validated; Region: PRK00153
700015005502	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
700015005503	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700015005504	Walker A motif; other site
700015005505	ATP binding site [chemical binding]; other site
700015005506	Walker B motif; other site
700015005507	arginine finger; other site
700015005508	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
700015005509	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
700015005510	Catalytic domain of Protein Kinases; Region: PKc; cd00180
700015005511	active site
700015005512	ATP binding site [chemical binding]; other site
700015005513	substrate binding site [chemical binding]; other site
700015005514	activation loop (A-loop); other site
700015005515	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
700015005516	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
700015005517	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
700015005518	phosphopeptide binding site; other site
700015005519	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
700015005520	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
700015005521	phosphopeptide binding site; other site
700015005522	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
700015005523	active site
700015005524	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
700015005525	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
700015005526	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
700015005527	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
700015005528	Catalytic domain of Protein Kinases; Region: PKc; cd00180
700015005529	active site
700015005530	ATP binding site [chemical binding]; other site
700015005531	substrate binding site [chemical binding]; other site
700015005532	activation loop (A-loop); other site
700015005533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
700015005534	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
700015005535	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
700015005536	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
700015005537	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
700015005538	hypothetical protein; Provisional; Region: PRK03881
700015005539	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
700015005540	AMMECR1; Region: AMMECR1; cl00911
700015005541	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
700015005542	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
700015005543	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
700015005544	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
700015005545	putative active site [active]
700015005546	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
700015005547	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
700015005548	putative substrate binding site [chemical binding]; other site
700015005549	putative ATP binding site [chemical binding]; other site
700015005550	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700015005551	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700015005552	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
700015005553	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
700015005554	Walker A/P-loop; other site
700015005555	ATP binding site [chemical binding]; other site
700015005556	Q-loop/lid; other site
700015005557	ABC transporter signature motif; other site
700015005558	Walker B; other site
700015005559	D-loop; other site
700015005560	H-loop/switch region; other site
700015005561	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
700015005562	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
700015005563	MFS/sugar transport protein; Region: MFS_2; pfam13347
700015005564	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
700015005565	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
700015005566	NADP binding site [chemical binding]; other site
700015005567	homodimer interface [polypeptide binding]; other site
700015005568	active site
700015005569	hypothetical protein; Provisional; Region: PRK09273
700015005570	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
700015005571	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
700015005572	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700015005573	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700015005574	DNA binding site [nucleotide binding]
700015005575	domain linker motif; other site
700015005576	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
700015005577	putative dimerization interface [polypeptide binding]; other site
700015005578	putative ligand binding site [chemical binding]; other site
700015005579	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
700015005580	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
700015005581	Glycosyl hydrolase family 43; Region: GH43_6; cd08985
700015005582	active site
700015005583	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
700015005584	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
700015005585	active site
700015005586	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
700015005587	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
700015005588	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
700015005589	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
700015005590	active site
700015005591	phosphorylation site [posttranslational modification]
700015005592	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
700015005593	active site
700015005594	active pocket/dimerization site; other site
700015005595	phosphorylation site [posttranslational modification]
700015005596	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752
700015005597	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
700015005598	active site
700015005599	phosphorylation site [posttranslational modification]
700015005600	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
700015005601	active site
700015005602	P-loop; other site
700015005603	phosphorylation site [posttranslational modification]
700015005604	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
700015005605	alpha-mannosidase; Provisional; Region: PRK09819
700015005606	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
700015005607	active site
700015005608	metal binding site [ion binding]; metal-binding site
700015005609	catalytic site [active]
700015005610	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
700015005611	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
700015005612	HTH domain; Region: HTH_11; pfam08279
700015005613	PRD domain; Region: PRD; pfam00874
700015005614	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
700015005615	active site
700015005616	P-loop; other site
700015005617	phosphorylation site [posttranslational modification]
700015005618	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
700015005619	active site
700015005620	phosphorylation site [posttranslational modification]
700015005621	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
700015005622	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700015005623	DNA-binding site [nucleotide binding]; DNA binding site
700015005624	UTRA domain; Region: UTRA; pfam07702
700015005625	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
700015005626	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
700015005627	Domain of unknown function (DUF303); Region: DUF303; pfam03629
700015005628	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
700015005629	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
700015005630	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015005631	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700015005632	putative substrate translocation pore; other site
700015005633	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
700015005634	Helix-turn-helix domain; Region: HTH_18; pfam12833
700015005635	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700015005636	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
700015005637	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
700015005638	inhibitor binding site; inhibition site
700015005639	active site
700015005640	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
700015005641	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
700015005642	nucleotide binding site [chemical binding]; other site
700015005643	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
700015005644	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700015005645	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
700015005646	active site
700015005647	motif I; other site
700015005648	motif II; other site
700015005649	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
700015005650	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700015005651	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700015005652	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
700015005653	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
700015005654	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
700015005655	Metal-binding active site; metal-binding site
700015005656	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700015005657	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700015005658	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
700015005659	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
700015005660	Double zinc ribbon; Region: DZR; pfam12773
700015005661	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
700015005662	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
700015005663	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
700015005664	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
700015005665	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
700015005666	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
700015005667	active site
700015005668	phosphorylation site [posttranslational modification]
700015005669	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
700015005670	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
700015005671	dimer interface [polypeptide binding]; other site
700015005672	active site
700015005673	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
700015005674	dimer interface [polypeptide binding]; other site
700015005675	active site
700015005676	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
700015005677	active pocket/dimerization site; other site
700015005678	active site
700015005679	phosphorylation site [posttranslational modification]
700015005680	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
700015005681	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700015005682	DNA-binding site [nucleotide binding]; DNA binding site
700015005683	UTRA domain; Region: UTRA; pfam07702
700015005684	L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407
700015005685	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
700015005686	hexamer (dimer of trimers) interface [polypeptide binding]; other site
700015005687	substrate binding site [chemical binding]; other site
700015005688	trimer interface [polypeptide binding]; other site
700015005689	Mn binding site [ion binding]; other site
700015005690	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
700015005691	N- and C-terminal domain interface [polypeptide binding]; other site
700015005692	D-xylulose kinase; Region: XylB; TIGR01312
700015005693	active site
700015005694	MgATP binding site [chemical binding]; other site
700015005695	catalytic site [active]
700015005696	metal binding site [ion binding]; metal-binding site
700015005697	xylulose binding site [chemical binding]; other site
700015005698	homodimer interface [polypeptide binding]; other site
700015005699	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
700015005700	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700015005701	putative substrate translocation pore; other site
700015005702	putative alpha-glucosidase; Provisional; Region: PRK10658
700015005703	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
700015005704	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
700015005705	active site
700015005706	homotrimer interface [polypeptide binding]; other site
700015005707	catalytic site [active]
700015005708	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
700015005709	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
700015005710	non-specific DNA interactions [nucleotide binding]; other site
700015005711	DNA binding site [nucleotide binding]
700015005712	sequence specific DNA binding site [nucleotide binding]; other site
700015005713	putative cAMP binding site [chemical binding]; other site
700015005714	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
700015005715	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
700015005716	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
700015005717	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
700015005718	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
700015005719	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
700015005720	TM-ABC transporter signature motif; other site
700015005721	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
700015005722	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
700015005723	Walker A/P-loop; other site
700015005724	ATP binding site [chemical binding]; other site
700015005725	Q-loop/lid; other site
700015005726	ABC transporter signature motif; other site
700015005727	Walker B; other site
700015005728	D-loop; other site
700015005729	H-loop/switch region; other site
700015005730	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
700015005731	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
700015005732	D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634
700015005733	putative ligand binding site [chemical binding]; other site
700015005734	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
700015005735	GIY-YIG motif/motif A; other site
700015005736	active site
700015005737	catalytic site [active]
700015005738	metal binding site [ion binding]; metal-binding site
700015005739	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
700015005740	Type III pantothenate kinase; Region: Pan_kinase; cl17198
700015005741	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
700015005742	substrate binding pocket [chemical binding]; other site
700015005743	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
700015005744	substrate binding pocket [chemical binding]; other site
700015005745	dimer interface [polypeptide binding]; other site
700015005746	inhibitor binding site; inhibition site
700015005747	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
700015005748	catalytic center binding site [active]
700015005749	ATP binding site [chemical binding]; other site
700015005750	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
700015005751	active site
700015005752	putative catalytic site [active]
700015005753	DNA binding site [nucleotide binding]
700015005754	putative phosphate binding site [ion binding]; other site
700015005755	metal binding site A [ion binding]; metal-binding site
700015005756	AP binding site [nucleotide binding]; other site
700015005757	metal binding site B [ion binding]; metal-binding site
700015005758	putative cation:proton antiport protein; Provisional; Region: PRK10669
700015005759	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
700015005760	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
700015005761	TrkA-N domain; Region: TrkA_N; pfam02254
700015005762	TrkA-C domain; Region: TrkA_C; pfam02080
700015005763	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
700015005764	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
700015005765	Substrate binding site; other site
700015005766	Mg++ binding site; other site
700015005767	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
700015005768	active site
700015005769	substrate binding site [chemical binding]; other site
700015005770	CoA binding site [chemical binding]; other site
700015005771	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
700015005772	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
700015005773	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700015005774	active site
700015005775	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
700015005776	putative active site [active]
700015005777	catalytic residue [active]
700015005778	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
700015005779	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
700015005780	CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720
700015005781	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
700015005782	CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd09644
700015005783	CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866
700015005784	tetramer interface [polypeptide binding]; other site
700015005785	putative DNA binding site [nucleotide binding]; other site
700015005786	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
700015005787	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
700015005788	FAD binding pocket [chemical binding]; other site
700015005789	FAD binding motif [chemical binding]; other site
700015005790	phosphate binding motif [ion binding]; other site
700015005791	beta-alpha-beta structure motif; other site
700015005792	NAD binding pocket [chemical binding]; other site
700015005793	Iron coordination center [ion binding]; other site
700015005794	putative oxidoreductase; Provisional; Region: PRK12831
700015005795	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700015005796	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
700015005797	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
700015005798	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700015005799	dimer interface [polypeptide binding]; other site
700015005800	conserved gate region; other site
700015005801	putative PBP binding loops; other site
700015005802	ABC-ATPase subunit interface; other site
700015005803	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
700015005804	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700015005805	dimer interface [polypeptide binding]; other site
700015005806	conserved gate region; other site
700015005807	putative PBP binding loops; other site
700015005808	ABC-ATPase subunit interface; other site
700015005809	bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917
700015005810	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
700015005811	substrate binding pocket [chemical binding]; other site
700015005812	membrane-bound complex binding site; other site
700015005813	hinge residues; other site
700015005814	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
700015005815	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
700015005816	Walker A/P-loop; other site
700015005817	ATP binding site [chemical binding]; other site
700015005818	Q-loop/lid; other site
700015005819	ABC transporter signature motif; other site
700015005820	Walker B; other site
700015005821	D-loop; other site
700015005822	H-loop/switch region; other site
700015005823	Yqey-like protein; Region: YqeY; cl17540
700015005824	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
700015005825	SurA N-terminal domain; Region: SurA_N_3; cl07813
700015005826	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
700015005827	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
700015005828	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
700015005829	active site
700015005830	substrate binding site [chemical binding]; other site
700015005831	cosubstrate binding site; other site
700015005832	catalytic site [active]
700015005833	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
700015005834	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
700015005835	dimerization interface [polypeptide binding]; other site
700015005836	putative ATP binding site [chemical binding]; other site
700015005837	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
700015005838	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
700015005839	active site
700015005840	tetramer interface [polypeptide binding]; other site
700015005841	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700015005842	active site
700015005843	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
700015005844	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
700015005845	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
700015005846	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
700015005847	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
700015005848	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
700015005849	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
700015005850	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
700015005851	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
700015005852	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
700015005853	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
700015005854	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
700015005855	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
700015005856	nucleotide binding site [chemical binding]; other site
700015005857	galactokinase; Provisional; Region: PRK05101
700015005858	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
700015005859	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
700015005860	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
700015005861	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
700015005862	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
700015005863	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
700015005864	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
700015005865	active site
700015005866	catalytic site [active]
700015005867	AIR carboxylase; Region: AIRC; pfam00731
700015005868	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
700015005869	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
700015005870	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
700015005871	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
700015005872	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
700015005873	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700015005874	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
700015005875	IMP binding site; other site
700015005876	dimer interface [polypeptide binding]; other site
700015005877	partial ornithine binding site; other site
700015005878	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
700015005879	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
700015005880	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
700015005881	catalytic site [active]
700015005882	subunit interface [polypeptide binding]; other site
700015005883	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
700015005884	dimer interface [polypeptide binding]; other site
700015005885	pyridoxal binding site [chemical binding]; other site
700015005886	ATP binding site [chemical binding]; other site
700015005887	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700015005888	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700015005889	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
700015005890	Walker A/P-loop; other site
700015005891	ATP binding site [chemical binding]; other site
700015005892	Q-loop/lid; other site
700015005893	ABC transporter signature motif; other site
700015005894	Walker B; other site
700015005895	D-loop; other site
700015005896	H-loop/switch region; other site
700015005897	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
700015005898	dimer interface [polypeptide binding]; other site
700015005899	ADP-ribose binding site [chemical binding]; other site
700015005900	active site
700015005901	nudix motif; other site
700015005902	metal binding site [ion binding]; metal-binding site
700015005903	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
700015005904	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
700015005905	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
700015005906	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
700015005907	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
700015005908	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
700015005909	GDP-binding site [chemical binding]; other site
700015005910	ACT binding site; other site
700015005911	IMP binding site; other site
700015005912	replicative DNA helicase; Region: DnaB; TIGR00665
700015005913	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
700015005914	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
700015005915	Walker A motif; other site
700015005916	ATP binding site [chemical binding]; other site
700015005917	Walker B motif; other site
700015005918	DNA binding loops [nucleotide binding]
700015005919	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
700015005920	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
700015005921	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
700015005922	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
700015005923	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
700015005924	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
700015005925	dimer interface [polypeptide binding]; other site
700015005926	ssDNA binding site [nucleotide binding]; other site
700015005927	tetramer (dimer of dimers) interface [polypeptide binding]; other site
700015005928	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
700015005929	Protein of unknown function (DUF4013); Region: DUF4013; pfam13197
700015005930	UPF0126 domain; Region: UPF0126; pfam03458
700015005931	Predicted membrane protein [Function unknown]; Region: COG2860
700015005932	UPF0126 domain; Region: UPF0126; pfam03458
700015005933	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
700015005934	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
700015005935	G1 box; other site
700015005936	putative GEF interaction site [polypeptide binding]; other site
700015005937	GTP/Mg2+ binding site [chemical binding]; other site
700015005938	Switch I region; other site
700015005939	G2 box; other site
700015005940	G3 box; other site
700015005941	Switch II region; other site
700015005942	G4 box; other site
700015005943	G5 box; other site
700015005944	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
700015005945	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
700015005946	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
700015005947	HSP70 interaction site [polypeptide binding]; other site
700015005948	Cna protein B-type domain; Region: Cna_B; pfam05738
700015005949	Cna protein B-type domain; Region: Cna_B; pfam05738
700015005950	Cna protein B-type domain; Region: Cna_B; pfam05738
700015005951	Cna protein B-type domain; Region: Cna_B; pfam05738
700015005952	Cna protein B-type domain; Region: Cna_B; pfam05738
700015005953	Cna protein B-type domain; Region: Cna_B; pfam05738
700015005954	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
700015005955	active site
700015005956	catalytic site [active]
700015005957	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
700015005958	C-terminal domain interface [polypeptide binding]; other site
700015005959	GSH binding site (G-site) [chemical binding]; other site
700015005960	dimer interface [polypeptide binding]; other site
700015005961	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
700015005962	metal binding site [ion binding]; metal-binding site
700015005963	DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
700015005964	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
700015005965	active site
700015005966	catalytic site [active]
700015005967	substrate binding site [chemical binding]; other site
700015005968	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
700015005969	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
700015005970	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
700015005971	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
700015005972	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
700015005973	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700015005974	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
700015005975	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700015005976	FeS/SAM binding site; other site
700015005977	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
700015005978	ParB-like nuclease domain; Region: ParB; smart00470
700015005979	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
700015005980	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
700015005981	P-loop; other site
700015005982	Magnesium ion binding site [ion binding]; other site
700015005983	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
700015005984	Magnesium ion binding site [ion binding]; other site
700015005985	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
700015005986	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726
700015005987	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
700015005988	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
700015005989	G-X-X-G motif; other site
700015005990	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
700015005991	RxxxH motif; other site
700015005992	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
700015005993	60Kd inner membrane protein; Region: 60KD_IMP; pfam02096
700015005994	Haemolytic domain; Region: Haemolytic; pfam01809
700015005995	Ribonuclease P; Region: Ribonuclease_P; pfam00825
700015005996	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399