-- dump date 20140619_050458 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1348662000001 DNA polymerase III subunit beta; Validated; Region: PRK07761 1348662000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1348662000003 putative DNA binding surface [nucleotide binding]; other site 1348662000004 dimer interface [polypeptide binding]; other site 1348662000005 beta-clamp/clamp loader binding surface; other site 1348662000006 beta-clamp/translesion DNA polymerase binding surface; other site 1348662000007 recF protein; Region: recf; TIGR00611 1348662000008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1348662000009 Walker A/P-loop; other site 1348662000010 ATP binding site [chemical binding]; other site 1348662000011 Q-loop/lid; other site 1348662000012 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1348662000013 ABC transporter signature motif; other site 1348662000014 Walker B; other site 1348662000015 D-loop; other site 1348662000016 H-loop/switch region; other site 1348662000017 Protein of unknown function (DUF721); Region: DUF721; cl02324 1348662000018 DNA gyrase, B subunit; Region: gyrB; TIGR01059 1348662000019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1348662000020 ATP binding site [chemical binding]; other site 1348662000021 Mg2+ binding site [ion binding]; other site 1348662000022 G-X-G motif; other site 1348662000023 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1348662000024 anchoring element; other site 1348662000025 dimer interface [polypeptide binding]; other site 1348662000026 ATP binding site [chemical binding]; other site 1348662000027 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1348662000028 active site 1348662000029 putative metal-binding site [ion binding]; other site 1348662000030 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1348662000031 DNA gyrase subunit A; Validated; Region: PRK05560 1348662000032 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1348662000033 CAP-like domain; other site 1348662000034 active site 1348662000035 primary dimer interface [polypeptide binding]; other site 1348662000036 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1348662000037 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1348662000038 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1348662000039 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1348662000040 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1348662000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1348662000042 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1348662000043 Phage capsid family; Region: Phage_capsid; pfam05065 1348662000044 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1348662000045 aminotransferase; Validated; Region: PRK09148 1348662000046 Helix-turn-helix domain; Region: HTH_17; pfam12728 1348662000047 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1348662000048 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1348662000049 non-specific DNA binding site [nucleotide binding]; other site 1348662000050 salt bridge; other site 1348662000051 sequence-specific DNA binding site [nucleotide binding]; other site 1348662000052 integrase; Provisional; Region: int; PHA02601 1348662000053 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1348662000054 active site 1348662000055 DNA binding site [nucleotide binding] 1348662000056 Int/Topo IB signature motif; other site 1348662000057 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1348662000058 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1348662000059 active site 1348662000060 Rhomboid family; Region: Rhomboid; pfam01694 1348662000061 putative septation inhibitor protein; Reviewed; Region: PRK00159 1348662000062 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1348662000063 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1348662000064 active site 1348662000065 ATP binding site [chemical binding]; other site 1348662000066 substrate binding site [chemical binding]; other site 1348662000067 activation loop (A-loop); other site 1348662000068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1348662000069 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1348662000070 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1348662000071 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1348662000072 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1348662000073 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1348662000074 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1348662000075 active site 1348662000076 ATP binding site [chemical binding]; other site 1348662000077 substrate binding site [chemical binding]; other site 1348662000078 activation loop (A-loop); other site 1348662000079 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1348662000080 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1348662000081 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1348662000082 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1348662000083 Protein phosphatase 2C; Region: PP2C; pfam00481 1348662000084 active site 1348662000085 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1348662000086 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1348662000087 phosphopeptide binding site; other site 1348662000088 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1348662000089 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1348662000090 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1348662000091 phosphopeptide binding site; other site 1348662000092 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1348662000093 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1348662000094 trimer interface [polypeptide binding]; other site 1348662000095 putative metal binding site [ion binding]; other site 1348662000096 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1348662000097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1348662000098 Coenzyme A binding pocket [chemical binding]; other site 1348662000099 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1348662000100 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1348662000101 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1348662000102 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1348662000103 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1348662000104 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1348662000105 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1348662000106 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1348662000107 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1348662000108 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1348662000109 active site 1348662000110 Citrate transporter; Region: CitMHS; pfam03600 1348662000111 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1348662000112 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1348662000113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1348662000114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1348662000115 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1348662000116 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1348662000117 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1348662000118 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1348662000119 tetrameric interface [polypeptide binding]; other site 1348662000120 NAD binding site [chemical binding]; other site 1348662000121 catalytic residues [active] 1348662000122 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1348662000123 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1348662000124 nucleotide binding region [chemical binding]; other site 1348662000125 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 1348662000126 Helicase associated domain (HA2); Region: HA2; cl04503 1348662000127 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1348662000128 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1348662000129 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1348662000130 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1348662000131 DNA binding site [nucleotide binding] 1348662000132 active site 1348662000133 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1348662000134 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1348662000135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1348662000136 NAD(P) binding site [chemical binding]; other site 1348662000137 active site 1348662000138 S4 domain; Region: S4_2; cl17325 1348662000139 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1348662000140 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1348662000141 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1348662000142 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1348662000143 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1348662000144 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1348662000145 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1348662000146 active site 1348662000147 Zn binding site [ion binding]; other site 1348662000148 Protease prsW family; Region: PrsW-protease; pfam13367 1348662000149 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1348662000150 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1348662000151 active site 1348662000152 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1348662000153 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1348662000154 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1348662000155 short chain dehydrogenase; Validated; Region: PRK08264 1348662000156 classical (c) SDRs; Region: SDR_c; cd05233 1348662000157 NAD(P) binding site [chemical binding]; other site 1348662000158 active site 1348662000159 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1348662000160 FAD binding domain; Region: FAD_binding_4; pfam01565 1348662000161 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1348662000162 Predicted membrane protein [Function unknown]; Region: COG2246 1348662000163 GtrA-like protein; Region: GtrA; pfam04138 1348662000164 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1348662000165 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1348662000166 active site 1348662000167 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1348662000168 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1348662000169 Walker A/P-loop; other site 1348662000170 ATP binding site [chemical binding]; other site 1348662000171 Q-loop/lid; other site 1348662000172 ABC transporter signature motif; other site 1348662000173 Walker B; other site 1348662000174 D-loop; other site 1348662000175 H-loop/switch region; other site 1348662000176 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1348662000177 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1348662000178 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1348662000179 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1348662000180 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1348662000181 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1348662000182 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1348662000183 NAD(P) binding site [chemical binding]; other site 1348662000184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662000185 CsbD-like; Region: CsbD; cl17424 1348662000186 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1348662000187 nucleoside/Zn binding site; other site 1348662000188 dimer interface [polypeptide binding]; other site 1348662000189 catalytic motif [active] 1348662000190 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1348662000191 prephenate dehydrogenase; Validated; Region: PRK08507 1348662000192 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1348662000193 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1348662000194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1348662000195 homodimer interface [polypeptide binding]; other site 1348662000196 catalytic residue [active] 1348662000197 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1348662000198 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1348662000199 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1348662000200 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1348662000201 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1348662000202 active site 1348662000203 HIGH motif; other site 1348662000204 nucleotide binding site [chemical binding]; other site 1348662000205 active site 1348662000206 KMSKS motif; other site 1348662000207 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1348662000208 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1348662000209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1348662000210 homodimer interface [polypeptide binding]; other site 1348662000211 catalytic residue [active] 1348662000212 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1348662000213 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1348662000214 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1348662000215 Walker A motif; other site 1348662000216 ATP binding site [chemical binding]; other site 1348662000217 Walker B motif; other site 1348662000218 arginine finger; other site 1348662000219 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1348662000220 hypothetical protein; Validated; Region: PRK00153 1348662000221 recombination protein RecR; Reviewed; Region: recR; PRK00076 1348662000222 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 1348662000223 RecR protein; Region: RecR; pfam02132 1348662000224 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1348662000225 putative active site [active] 1348662000226 putative metal-binding site [ion binding]; other site 1348662000227 tetramer interface [polypeptide binding]; other site 1348662000228 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1348662000229 catalytic triad [active] 1348662000230 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1348662000231 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1348662000232 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1348662000233 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1348662000234 active site 1348662000235 catalytic site [active] 1348662000236 substrate binding site [chemical binding]; other site 1348662000237 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1348662000238 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1348662000239 phosphate binding site [ion binding]; other site 1348662000240 2-isopropylmalate synthase; Validated; Region: PRK03739 1348662000241 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1348662000242 active site 1348662000243 catalytic residues [active] 1348662000244 metal binding site [ion binding]; metal-binding site 1348662000245 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1348662000246 AzlC protein; Region: AzlC; pfam03591 1348662000247 aspartate kinase; Reviewed; Region: PRK06635 1348662000248 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1348662000249 putative nucleotide binding site [chemical binding]; other site 1348662000250 putative catalytic residues [active] 1348662000251 putative Mg ion binding site [ion binding]; other site 1348662000252 putative aspartate binding site [chemical binding]; other site 1348662000253 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1348662000254 putative allosteric regulatory site; other site 1348662000255 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1348662000256 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1348662000257 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1348662000258 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1348662000259 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1348662000260 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1348662000261 DNA binding residues [nucleotide binding] 1348662000262 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1348662000263 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1348662000264 tetramer interface [polypeptide binding]; other site 1348662000265 heme binding pocket [chemical binding]; other site 1348662000266 NADPH binding site [chemical binding]; other site 1348662000267 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 1348662000268 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 1348662000269 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1348662000270 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1348662000271 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 1348662000272 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 1348662000273 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1348662000274 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1348662000275 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1348662000276 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1348662000277 Predicted membrane protein [Function unknown]; Region: COG1511 1348662000278 Predicted membrane protein [Function unknown]; Region: COG1511 1348662000279 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 1348662000280 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1348662000281 active site 1348662000282 metal binding site [ion binding]; metal-binding site 1348662000283 Transglycosylase; Region: Transgly; pfam00912 1348662000284 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1348662000285 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1348662000286 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1348662000287 Transcription factor WhiB; Region: Whib; pfam02467 1348662000288 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1348662000289 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1348662000290 homotrimer interaction site [polypeptide binding]; other site 1348662000291 putative active site [active] 1348662000292 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1348662000293 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1348662000294 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1348662000295 ligand binding site [chemical binding]; other site 1348662000296 flexible hinge region; other site 1348662000297 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1348662000298 putative switch regulator; other site 1348662000299 non-specific DNA interactions [nucleotide binding]; other site 1348662000300 DNA binding site [nucleotide binding] 1348662000301 sequence specific DNA binding site [nucleotide binding]; other site 1348662000302 putative cAMP binding site [chemical binding]; other site 1348662000303 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1348662000304 endonuclease III; Region: ENDO3c; smart00478 1348662000305 minor groove reading motif; other site 1348662000306 helix-hairpin-helix signature motif; other site 1348662000307 substrate binding pocket [chemical binding]; other site 1348662000308 active site 1348662000309 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1348662000310 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1348662000311 catalytic residues [active] 1348662000312 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1348662000313 putative active site [active] 1348662000314 putative CoA binding site [chemical binding]; other site 1348662000315 nudix motif; other site 1348662000316 metal binding site [ion binding]; metal-binding site 1348662000317 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1348662000318 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1348662000319 motif II; other site 1348662000320 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1348662000321 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1348662000322 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1348662000323 Type II/IV secretion system protein; Region: T2SE; pfam00437 1348662000324 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1348662000325 Walker A motif; other site 1348662000326 hexamer interface [polypeptide binding]; other site 1348662000327 ATP binding site [chemical binding]; other site 1348662000328 Walker B motif; other site 1348662000329 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1348662000330 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1348662000331 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1348662000332 ATP binding site [chemical binding]; other site 1348662000333 putative Mg++ binding site [ion binding]; other site 1348662000334 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1348662000335 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1348662000336 DNA-binding site [nucleotide binding]; DNA binding site 1348662000337 RNA-binding motif; other site 1348662000338 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1348662000339 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1348662000340 active site 1348662000341 interdomain interaction site; other site 1348662000342 putative metal-binding site [ion binding]; other site 1348662000343 nucleotide binding site [chemical binding]; other site 1348662000344 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1348662000345 domain I; other site 1348662000346 phosphate binding site [ion binding]; other site 1348662000347 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1348662000348 domain II; other site 1348662000349 domain III; other site 1348662000350 nucleotide binding site [chemical binding]; other site 1348662000351 DNA binding groove [nucleotide binding] 1348662000352 catalytic site [active] 1348662000353 domain IV; other site 1348662000354 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1348662000355 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1348662000356 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1348662000357 Putative esterase; Region: Esterase; pfam00756 1348662000358 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1348662000359 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1348662000360 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1348662000361 NAD binding site [chemical binding]; other site 1348662000362 substrate binding site [chemical binding]; other site 1348662000363 homodimer interface [polypeptide binding]; other site 1348662000364 active site 1348662000365 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1348662000366 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1348662000367 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1348662000368 NADP binding site [chemical binding]; other site 1348662000369 active site 1348662000370 putative substrate binding site [chemical binding]; other site 1348662000371 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1348662000372 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1348662000373 substrate binding site; other site 1348662000374 tetramer interface; other site 1348662000375 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1348662000376 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1348662000377 Probable Catalytic site; other site 1348662000378 metal-binding site 1348662000379 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1348662000380 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1348662000381 Ligand binding site; other site 1348662000382 Putative Catalytic site; other site 1348662000383 DXD motif; other site 1348662000384 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1348662000385 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1348662000386 Thioredoxin; Region: Thioredoxin_4; cl17273 1348662000387 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1348662000388 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1348662000389 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1348662000390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1348662000391 NAD(P) binding site [chemical binding]; other site 1348662000392 active site 1348662000393 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1348662000394 dimerization interface [polypeptide binding]; other site 1348662000395 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1348662000396 cyclase homology domain; Region: CHD; cd07302 1348662000397 nucleotidyl binding site; other site 1348662000398 metal binding site [ion binding]; metal-binding site 1348662000399 dimer interface [polypeptide binding]; other site 1348662000400 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1348662000401 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1348662000402 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1348662000403 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1348662000404 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1348662000405 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1348662000406 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1348662000407 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1348662000408 non-specific DNA binding site [nucleotide binding]; other site 1348662000409 salt bridge; other site 1348662000410 sequence-specific DNA binding site [nucleotide binding]; other site 1348662000411 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1348662000412 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1348662000413 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1348662000414 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1348662000415 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1348662000416 putative Iron-sulfur protein interface [polypeptide binding]; other site 1348662000417 proximal heme binding site [chemical binding]; other site 1348662000418 distal heme binding site [chemical binding]; other site 1348662000419 putative dimer interface [polypeptide binding]; other site 1348662000420 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1348662000421 L-aspartate oxidase; Provisional; Region: PRK06175 1348662000422 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1348662000423 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1348662000424 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1348662000425 Predicted membrane protein [Function unknown]; Region: COG2733 1348662000426 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1348662000427 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1348662000428 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1348662000429 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1348662000430 putative active site [active] 1348662000431 putative substrate binding site [chemical binding]; other site 1348662000432 putative cosubstrate binding site; other site 1348662000433 catalytic site [active] 1348662000434 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1348662000435 intersubunit interface [polypeptide binding]; other site 1348662000436 active site 1348662000437 catalytic residue [active] 1348662000438 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1348662000439 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1348662000440 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1348662000441 FAD binding domain; Region: FAD_binding_4; pfam01565 1348662000442 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1348662000443 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1348662000444 ThiC-associated domain; Region: ThiC-associated; pfam13667 1348662000445 ThiC family; Region: ThiC; pfam01964 1348662000446 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 1348662000447 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1348662000448 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1348662000449 acyl-activating enzyme (AAE) consensus motif; other site 1348662000450 AMP binding site [chemical binding]; other site 1348662000451 active site 1348662000452 CoA binding site [chemical binding]; other site 1348662000453 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1348662000454 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1348662000455 putative ADP-binding pocket [chemical binding]; other site 1348662000456 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1348662000457 catalytic core [active] 1348662000458 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1348662000459 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1348662000460 FtsX-like permease family; Region: FtsX; pfam02687 1348662000461 FtsX-like permease family; Region: FtsX; pfam02687 1348662000462 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1348662000463 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1348662000464 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1348662000465 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1348662000466 DNA binding domain, excisionase family; Region: excise; TIGR01764 1348662000467 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1348662000468 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1348662000469 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1348662000470 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1348662000471 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1348662000472 tRNA; other site 1348662000473 putative tRNA binding site [nucleotide binding]; other site 1348662000474 putative NADP binding site [chemical binding]; other site 1348662000475 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1348662000476 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1348662000477 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1348662000478 domain interfaces; other site 1348662000479 active site 1348662000480 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1348662000481 active site 1348662000482 homodimer interface [polypeptide binding]; other site 1348662000483 SAM binding site [chemical binding]; other site 1348662000484 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1348662000485 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1348662000486 active site 1348662000487 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1348662000488 dimer interface [polypeptide binding]; other site 1348662000489 active site 1348662000490 Schiff base residues; other site 1348662000491 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1348662000492 substrate binding site [chemical binding]; other site 1348662000493 active site 1348662000494 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1348662000495 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1348662000496 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1348662000497 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1348662000498 inhibitor-cofactor binding pocket; inhibition site 1348662000499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1348662000500 catalytic residue [active] 1348662000501 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1348662000502 catalytic core [active] 1348662000503 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1348662000504 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1348662000505 catalytic residues [active] 1348662000506 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1348662000507 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1348662000508 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1348662000509 ResB-like family; Region: ResB; pfam05140 1348662000510 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1348662000511 PE-PPE domain; Region: PE-PPE; pfam08237 1348662000512 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1348662000513 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1348662000514 UbiA prenyltransferase family; Region: UbiA; pfam01040 1348662000515 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1348662000516 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1348662000517 acyl-activating enzyme (AAE) consensus motif; other site 1348662000518 AMP binding site [chemical binding]; other site 1348662000519 active site 1348662000520 CoA binding site [chemical binding]; other site 1348662000521 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1348662000522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1348662000523 Walker A/P-loop; other site 1348662000524 ATP binding site [chemical binding]; other site 1348662000525 Q-loop/lid; other site 1348662000526 ABC transporter signature motif; other site 1348662000527 Walker B; other site 1348662000528 D-loop; other site 1348662000529 H-loop/switch region; other site 1348662000530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1348662000531 Walker A/P-loop; other site 1348662000532 ATP binding site [chemical binding]; other site 1348662000533 Q-loop/lid; other site 1348662000534 ABC transporter signature motif; other site 1348662000535 Walker B; other site 1348662000536 D-loop; other site 1348662000537 H-loop/switch region; other site 1348662000538 Cobalt transport protein; Region: CbiQ; cl00463 1348662000539 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1348662000540 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1348662000541 FAD binding pocket [chemical binding]; other site 1348662000542 FAD binding motif [chemical binding]; other site 1348662000543 phosphate binding motif [ion binding]; other site 1348662000544 NAD binding pocket [chemical binding]; other site 1348662000545 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1348662000546 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1348662000547 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1348662000548 substrate binding site [chemical binding]; other site 1348662000549 oxyanion hole (OAH) forming residues; other site 1348662000550 trimer interface [polypeptide binding]; other site 1348662000551 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1348662000552 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1348662000553 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1348662000554 active site 1348662000555 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 1348662000556 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1348662000557 dimer interface [polypeptide binding]; other site 1348662000558 tetramer interface [polypeptide binding]; other site 1348662000559 PYR/PP interface [polypeptide binding]; other site 1348662000560 TPP binding site [chemical binding]; other site 1348662000561 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1348662000562 TPP-binding site; other site 1348662000563 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1348662000564 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1348662000565 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1348662000566 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1348662000567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1348662000568 S-adenosylmethionine binding site [chemical binding]; other site 1348662000569 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1348662000570 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1348662000571 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1348662000572 substrate binding pocket [chemical binding]; other site 1348662000573 chain length determination region; other site 1348662000574 substrate-Mg2+ binding site; other site 1348662000575 catalytic residues [active] 1348662000576 aspartate-rich region 1; other site 1348662000577 active site lid residues [active] 1348662000578 aspartate-rich region 2; other site 1348662000579 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1348662000580 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1348662000581 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1348662000582 putative homodimer interface [polypeptide binding]; other site 1348662000583 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1348662000584 heterodimer interface [polypeptide binding]; other site 1348662000585 homodimer interface [polypeptide binding]; other site 1348662000586 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1348662000587 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1348662000588 23S rRNA interface [nucleotide binding]; other site 1348662000589 L7/L12 interface [polypeptide binding]; other site 1348662000590 putative thiostrepton binding site; other site 1348662000591 L25 interface [polypeptide binding]; other site 1348662000592 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1348662000593 mRNA/rRNA interface [nucleotide binding]; other site 1348662000594 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 1348662000595 dimer interface [polypeptide binding]; other site 1348662000596 catalytic triad [active] 1348662000597 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1348662000598 23S rRNA interface [nucleotide binding]; other site 1348662000599 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1348662000600 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1348662000601 peripheral dimer interface [polypeptide binding]; other site 1348662000602 core dimer interface [polypeptide binding]; other site 1348662000603 L10 interface [polypeptide binding]; other site 1348662000604 L11 interface [polypeptide binding]; other site 1348662000605 putative EF-Tu interaction site [polypeptide binding]; other site 1348662000606 putative EF-G interaction site [polypeptide binding]; other site 1348662000607 OsmC-like protein; Region: OsmC; pfam02566 1348662000608 Htaa; Region: HtaA; pfam04213 1348662000609 Immunoglobulin like; Region: IG_like; smart00410 1348662000610 Predicted permease; Region: DUF318; cl17795 1348662000611 Predicted permease; Region: DUF318; cl17795 1348662000612 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 1348662000613 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1348662000614 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1348662000615 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1348662000616 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1348662000617 RPB1 interaction site [polypeptide binding]; other site 1348662000618 RPB10 interaction site [polypeptide binding]; other site 1348662000619 RPB11 interaction site [polypeptide binding]; other site 1348662000620 RPB3 interaction site [polypeptide binding]; other site 1348662000621 RPB12 interaction site [polypeptide binding]; other site 1348662000622 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1348662000623 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1348662000624 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1348662000625 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1348662000626 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1348662000627 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1348662000628 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1348662000629 G-loop; other site 1348662000630 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1348662000631 DNA binding site [nucleotide binding] 1348662000632 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1348662000633 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1348662000634 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1348662000635 Fic/DOC family; Region: Fic; cl00960 1348662000636 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1348662000637 S17 interaction site [polypeptide binding]; other site 1348662000638 S8 interaction site; other site 1348662000639 16S rRNA interaction site [nucleotide binding]; other site 1348662000640 streptomycin interaction site [chemical binding]; other site 1348662000641 23S rRNA interaction site [nucleotide binding]; other site 1348662000642 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1348662000643 30S ribosomal protein S7; Validated; Region: PRK05302 1348662000644 elongation factor G; Reviewed; Region: PRK00007 1348662000645 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1348662000646 G1 box; other site 1348662000647 putative GEF interaction site [polypeptide binding]; other site 1348662000648 GTP/Mg2+ binding site [chemical binding]; other site 1348662000649 Switch I region; other site 1348662000650 G2 box; other site 1348662000651 G3 box; other site 1348662000652 Switch II region; other site 1348662000653 G4 box; other site 1348662000654 G5 box; other site 1348662000655 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1348662000656 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1348662000657 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1348662000658 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1348662000659 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1348662000660 substrate binding pocket [chemical binding]; other site 1348662000661 membrane-bound complex binding site; other site 1348662000662 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1348662000663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1348662000664 dimer interface [polypeptide binding]; other site 1348662000665 conserved gate region; other site 1348662000666 putative PBP binding loops; other site 1348662000667 ABC-ATPase subunit interface; other site 1348662000668 elongation factor Tu; Reviewed; Region: PRK00049 1348662000669 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1348662000670 G1 box; other site 1348662000671 GEF interaction site [polypeptide binding]; other site 1348662000672 GTP/Mg2+ binding site [chemical binding]; other site 1348662000673 Switch I region; other site 1348662000674 G2 box; other site 1348662000675 G3 box; other site 1348662000676 Switch II region; other site 1348662000677 G4 box; other site 1348662000678 G5 box; other site 1348662000679 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1348662000680 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1348662000681 Antibiotic Binding Site [chemical binding]; other site 1348662000682 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1348662000683 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1348662000684 hypothetical protein; Provisional; Region: PRK02947 1348662000685 putative active site [active] 1348662000686 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1348662000687 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1348662000688 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1348662000689 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1348662000690 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1348662000691 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1348662000692 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1348662000693 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1348662000694 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1348662000695 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1348662000696 putative translocon binding site; other site 1348662000697 protein-rRNA interface [nucleotide binding]; other site 1348662000698 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1348662000699 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1348662000700 G-X-X-G motif; other site 1348662000701 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1348662000702 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1348662000703 23S rRNA interface [nucleotide binding]; other site 1348662000704 5S rRNA interface [nucleotide binding]; other site 1348662000705 putative antibiotic binding site [chemical binding]; other site 1348662000706 L25 interface [polypeptide binding]; other site 1348662000707 L27 interface [polypeptide binding]; other site 1348662000708 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1348662000709 putative translocon interaction site; other site 1348662000710 23S rRNA interface [nucleotide binding]; other site 1348662000711 signal recognition particle (SRP54) interaction site; other site 1348662000712 L23 interface [polypeptide binding]; other site 1348662000713 trigger factor interaction site; other site 1348662000714 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1348662000715 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1348662000716 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1348662000717 DNA binding residues [nucleotide binding] 1348662000718 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1348662000719 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1348662000720 FAD binding pocket [chemical binding]; other site 1348662000721 FAD binding motif [chemical binding]; other site 1348662000722 phosphate binding motif [ion binding]; other site 1348662000723 NAD binding pocket [chemical binding]; other site 1348662000724 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1348662000725 LGFP repeat; Region: LGFP; pfam08310 1348662000726 LGFP repeat; Region: LGFP; pfam08310 1348662000727 LGFP repeat; Region: LGFP; pfam08310 1348662000728 short chain dehydrogenase; Provisional; Region: PRK06500 1348662000729 classical (c) SDRs; Region: SDR_c; cd05233 1348662000730 NAD(P) binding site [chemical binding]; other site 1348662000731 active site 1348662000732 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1348662000733 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1348662000734 tetrameric interface [polypeptide binding]; other site 1348662000735 NAD binding site [chemical binding]; other site 1348662000736 catalytic residues [active] 1348662000737 substrate binding site [chemical binding]; other site 1348662000738 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1348662000739 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1348662000740 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1348662000741 Ligand Binding Site [chemical binding]; other site 1348662000742 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1348662000743 lysine transporter; Provisional; Region: PRK10836 1348662000744 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1348662000745 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1348662000746 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1348662000747 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1348662000748 RNA binding site [nucleotide binding]; other site 1348662000749 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1348662000750 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1348662000751 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1348662000752 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1348662000753 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1348662000754 HlyD family secretion protein; Region: HlyD_3; pfam13437 1348662000755 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1348662000756 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1348662000757 Walker A/P-loop; other site 1348662000758 ATP binding site [chemical binding]; other site 1348662000759 Q-loop/lid; other site 1348662000760 ABC transporter signature motif; other site 1348662000761 Walker B; other site 1348662000762 D-loop; other site 1348662000763 H-loop/switch region; other site 1348662000764 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1348662000765 FtsX-like permease family; Region: FtsX; pfam02687 1348662000766 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 1348662000767 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1348662000768 putative ligand binding site [chemical binding]; other site 1348662000769 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1348662000770 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1348662000771 TM-ABC transporter signature motif; other site 1348662000772 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1348662000773 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1348662000774 Walker A/P-loop; other site 1348662000775 ATP binding site [chemical binding]; other site 1348662000776 Q-loop/lid; other site 1348662000777 ABC transporter signature motif; other site 1348662000778 Walker B; other site 1348662000779 D-loop; other site 1348662000780 H-loop/switch region; other site 1348662000781 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 1348662000782 dimer interface [polypeptide binding]; other site 1348662000783 FMN binding site [chemical binding]; other site 1348662000784 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1348662000785 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1348662000786 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1348662000787 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1348662000788 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1348662000789 5S rRNA interface [nucleotide binding]; other site 1348662000790 L27 interface [polypeptide binding]; other site 1348662000791 23S rRNA interface [nucleotide binding]; other site 1348662000792 L5 interface [polypeptide binding]; other site 1348662000793 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1348662000794 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1348662000795 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1348662000796 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1348662000797 23S rRNA binding site [nucleotide binding]; other site 1348662000798 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1348662000799 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1348662000800 SecY translocase; Region: SecY; pfam00344 1348662000801 adenylate kinase; Reviewed; Region: adk; PRK00279 1348662000802 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1348662000803 AMP-binding site [chemical binding]; other site 1348662000804 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1348662000805 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1348662000806 active site 1348662000807 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1348662000808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1348662000809 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1348662000810 rRNA binding site [nucleotide binding]; other site 1348662000811 predicted 30S ribosome binding site; other site 1348662000812 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1348662000813 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1348662000814 30S ribosomal protein S11; Validated; Region: PRK05309 1348662000815 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1348662000816 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1348662000817 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1348662000818 RNA binding surface [nucleotide binding]; other site 1348662000819 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1348662000820 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1348662000821 alphaNTD - beta interaction site [polypeptide binding]; other site 1348662000822 alphaNTD homodimer interface [polypeptide binding]; other site 1348662000823 alphaNTD - beta' interaction site [polypeptide binding]; other site 1348662000824 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1348662000825 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1348662000826 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1348662000827 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1348662000828 dimerization interface 3.5A [polypeptide binding]; other site 1348662000829 active site 1348662000830 Protein of unknown function (DUF690); Region: DUF690; cl04939 1348662000831 Protein of unknown function (DUF690); Region: DUF690; cl04939 1348662000832 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1348662000833 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1348662000834 acyl-activating enzyme (AAE) consensus motif; other site 1348662000835 AMP binding site [chemical binding]; other site 1348662000836 active site 1348662000837 CoA binding site [chemical binding]; other site 1348662000838 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1348662000839 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1348662000840 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1348662000841 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1348662000842 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1348662000843 active site 1348662000844 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1348662000845 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1348662000846 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1348662000847 putative active site pocket [active] 1348662000848 cleavage site 1348662000849 glutamate racemase; Provisional; Region: PRK00865 1348662000850 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1348662000851 ribonuclease PH; Reviewed; Region: rph; PRK00173 1348662000852 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1348662000853 hexamer interface [polypeptide binding]; other site 1348662000854 active site 1348662000855 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1348662000856 active site 1348662000857 dimerization interface [polypeptide binding]; other site 1348662000858 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1348662000859 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1348662000860 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1348662000861 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1348662000862 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1348662000863 phosphate binding site [ion binding]; other site 1348662000864 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1348662000865 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1348662000866 active site 2 [active] 1348662000867 active site 1 [active] 1348662000868 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1348662000869 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1348662000870 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1348662000871 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1348662000872 putative NAD(P) binding site [chemical binding]; other site 1348662000873 active site 1348662000874 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1348662000875 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1348662000876 active site 1348662000877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1348662000878 ATP binding site [chemical binding]; other site 1348662000879 G-X-G motif; other site 1348662000880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1348662000881 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1348662000882 DNA binding site [nucleotide binding] 1348662000883 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1348662000884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 1348662000885 hypothetical protein; Provisional; Region: PRK13663 1348662000886 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1348662000887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1348662000888 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1348662000889 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1348662000890 catalytic triad [active] 1348662000891 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1348662000892 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1348662000893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1348662000894 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1348662000895 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1348662000896 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1348662000897 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1348662000898 catalytic site [active] 1348662000899 putative active site [active] 1348662000900 putative substrate binding site [chemical binding]; other site 1348662000901 dimer interface [polypeptide binding]; other site 1348662000902 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1348662000903 classical (c) SDRs; Region: SDR_c; cd05233 1348662000904 NAD(P) binding site [chemical binding]; other site 1348662000905 active site 1348662000906 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1348662000907 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1348662000908 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1348662000909 active site 1348662000910 Maf-like protein; Region: Maf; pfam02545 1348662000911 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1348662000912 active site 1348662000913 dimer interface [polypeptide binding]; other site 1348662000914 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1348662000915 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1348662000916 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1348662000917 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1348662000918 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1348662000919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1348662000920 S-adenosylmethionine binding site [chemical binding]; other site 1348662000921 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1348662000922 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1348662000923 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1348662000924 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1348662000925 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1348662000926 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1348662000927 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1348662000928 LabA_like proteins; Region: LabA_like/DUF88; cl10034 1348662000929 ATP-grasp domain; Region: ATP-grasp; pfam02222 1348662000930 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1348662000931 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1348662000932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1348662000933 dimer interface [polypeptide binding]; other site 1348662000934 conserved gate region; other site 1348662000935 putative PBP binding loops; other site 1348662000936 ABC-ATPase subunit interface; other site 1348662000937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1348662000938 dimer interface [polypeptide binding]; other site 1348662000939 conserved gate region; other site 1348662000940 putative PBP binding loops; other site 1348662000941 ABC-ATPase subunit interface; other site 1348662000942 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1348662000943 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1348662000944 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1348662000945 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1348662000946 Walker A/P-loop; other site 1348662000947 ATP binding site [chemical binding]; other site 1348662000948 Q-loop/lid; other site 1348662000949 ABC transporter signature motif; other site 1348662000950 Walker B; other site 1348662000951 D-loop; other site 1348662000952 H-loop/switch region; other site 1348662000953 TOBE domain; Region: TOBE_2; pfam08402 1348662000954 TIGR03089 family protein; Region: TIGR03089 1348662000955 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1348662000956 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1348662000957 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1348662000958 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1348662000959 Probable Catalytic site; other site 1348662000960 metal-binding site 1348662000961 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1348662000962 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1348662000963 active site 1348662000964 Substrate binding site; other site 1348662000965 Mg++ binding site; other site 1348662000966 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 1348662000967 Transcription factor WhiB; Region: Whib; pfam02467 1348662000968 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1348662000969 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1348662000970 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1348662000971 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1348662000972 active site 1348662000973 substrate binding site [chemical binding]; other site 1348662000974 metal binding site [ion binding]; metal-binding site 1348662000975 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1348662000976 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1348662000977 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1348662000978 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 1348662000979 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1348662000980 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1348662000981 homotetramer interface [polypeptide binding]; other site 1348662000982 ligand binding site [chemical binding]; other site 1348662000983 catalytic site [active] 1348662000984 NAD binding site [chemical binding]; other site 1348662000985 thymidylate kinase; Validated; Region: PRK07933 1348662000986 HSP90 family protein; Provisional; Region: PRK14083 1348662000987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1348662000988 ATP binding site [chemical binding]; other site 1348662000989 Mg2+ binding site [ion binding]; other site 1348662000990 G-X-G motif; other site 1348662000991 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1348662000992 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 1348662000993 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1348662000994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1348662000995 active site 1348662000996 phosphorylation site [posttranslational modification] 1348662000997 intermolecular recognition site; other site 1348662000998 dimerization interface [polypeptide binding]; other site 1348662000999 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1348662001000 DNA binding site [nucleotide binding] 1348662001001 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1348662001002 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1348662001003 dimerization interface [polypeptide binding]; other site 1348662001004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1348662001005 dimer interface [polypeptide binding]; other site 1348662001006 phosphorylation site [posttranslational modification] 1348662001007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1348662001008 ATP binding site [chemical binding]; other site 1348662001009 Mg2+ binding site [ion binding]; other site 1348662001010 G-X-G motif; other site 1348662001011 lipoprotein LpqB; Provisional; Region: PRK13616 1348662001012 Sporulation and spore germination; Region: Germane; pfam10646 1348662001013 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1348662001014 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1348662001015 active site 1348662001016 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1348662001017 30S subunit binding site; other site 1348662001018 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1348662001019 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1348662001020 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1348662001021 nucleotide binding region [chemical binding]; other site 1348662001022 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1348662001023 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1348662001024 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1348662001025 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1348662001026 FAD binding pocket [chemical binding]; other site 1348662001027 FAD binding motif [chemical binding]; other site 1348662001028 phosphate binding motif [ion binding]; other site 1348662001029 beta-alpha-beta structure motif; other site 1348662001030 NAD binding pocket [chemical binding]; other site 1348662001031 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1348662001032 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1348662001033 catalytic loop [active] 1348662001034 iron binding site [ion binding]; other site 1348662001035 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1348662001036 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1348662001037 putative di-iron ligands [ion binding]; other site 1348662001038 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1348662001039 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1348662001040 Cl- selectivity filter; other site 1348662001041 Cl- binding residues [ion binding]; other site 1348662001042 pore gating glutamate residue; other site 1348662001043 dimer interface [polypeptide binding]; other site 1348662001044 Predicted GTPases [General function prediction only]; Region: COG1162 1348662001045 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1348662001046 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1348662001047 GTP/Mg2+ binding site [chemical binding]; other site 1348662001048 G4 box; other site 1348662001049 G5 box; other site 1348662001050 G1 box; other site 1348662001051 Switch I region; other site 1348662001052 G2 box; other site 1348662001053 G3 box; other site 1348662001054 Switch II region; other site 1348662001055 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1348662001056 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1348662001057 hinge; other site 1348662001058 active site 1348662001059 Predicted membrane protein [Function unknown]; Region: COG4270 1348662001060 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1348662001061 putative deacylase active site [active] 1348662001062 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1348662001063 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1348662001064 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1348662001065 DNA binding residues [nucleotide binding] 1348662001066 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1348662001067 Transcription factor WhiB; Region: Whib; pfam02467 1348662001068 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1348662001069 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1348662001070 ATP binding site [chemical binding]; other site 1348662001071 Mg++ binding site [ion binding]; other site 1348662001072 motif III; other site 1348662001073 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1348662001074 nucleotide binding region [chemical binding]; other site 1348662001075 ATP-binding site [chemical binding]; other site 1348662001076 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1348662001077 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1348662001078 TIGR02569 family protein; Region: TIGR02569_actnb 1348662001079 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1348662001080 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1348662001081 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1348662001082 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1348662001083 Family description; Region: UvrD_C_2; pfam13538 1348662001084 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1348662001085 Ion channel; Region: Ion_trans_2; pfam07885 1348662001086 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1348662001087 TrkA-N domain; Region: TrkA_N; pfam02254 1348662001088 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1348662001089 putative NADH binding site [chemical binding]; other site 1348662001090 putative active site [active] 1348662001091 nudix motif; other site 1348662001092 putative metal binding site [ion binding]; other site 1348662001093 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1348662001094 Part of AAA domain; Region: AAA_19; pfam13245 1348662001095 Family description; Region: UvrD_C_2; pfam13538 1348662001096 HRDC domain; Region: HRDC; pfam00570 1348662001097 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1348662001098 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1348662001099 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1348662001100 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1348662001101 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1348662001102 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1348662001103 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1348662001104 hypothetical protein; Validated; Region: PRK00068 1348662001105 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1348662001106 active site 1348662001107 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1348662001108 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1348662001109 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1348662001110 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1348662001111 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1348662001112 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1348662001113 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1348662001114 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1348662001115 ATP binding site [chemical binding]; other site 1348662001116 putative Mg++ binding site [ion binding]; other site 1348662001117 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 1348662001118 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1348662001119 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1348662001120 catalytic residues [active] 1348662001121 catalytic nucleophile [active] 1348662001122 Presynaptic Site I dimer interface [polypeptide binding]; other site 1348662001123 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1348662001124 Synaptic Flat tetramer interface [polypeptide binding]; other site 1348662001125 Synaptic Site I dimer interface [polypeptide binding]; other site 1348662001126 DNA binding site [nucleotide binding] 1348662001127 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1348662001128 DNA-binding interface [nucleotide binding]; DNA binding site 1348662001129 Resolvase, N terminal domain; Region: Resolvase; pfam00239 1348662001130 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1348662001131 catalytic residues [active] 1348662001132 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1348662001133 DNA-binding interface [nucleotide binding]; DNA binding site 1348662001134 oxaloacetate decarboxylase; Provisional; Region: PRK12330 1348662001135 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1348662001136 active site 1348662001137 catalytic residues [active] 1348662001138 metal binding site [ion binding]; metal-binding site 1348662001139 homodimer binding site [polypeptide binding]; other site 1348662001140 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1348662001141 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1348662001142 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1348662001143 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1348662001144 carboxyltransferase (CT) interaction site; other site 1348662001145 biotinylation site [posttranslational modification]; other site 1348662001146 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1348662001147 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1348662001148 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1348662001149 active site 1348662001150 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1348662001151 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1348662001152 active site 1348662001153 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1348662001154 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1348662001155 RF-1 domain; Region: RF-1; pfam00472 1348662001156 AbgT putative transporter family; Region: ABG_transport; cl17431 1348662001157 AbgT putative transporter family; Region: ABG_transport; cl17431 1348662001158 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1348662001159 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1348662001160 Walker A/P-loop; other site 1348662001161 ATP binding site [chemical binding]; other site 1348662001162 Q-loop/lid; other site 1348662001163 ABC transporter signature motif; other site 1348662001164 Walker B; other site 1348662001165 D-loop; other site 1348662001166 H-loop/switch region; other site 1348662001167 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1348662001168 FtsX-like permease family; Region: FtsX; pfam02687 1348662001169 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1348662001170 SmpB-tmRNA interface; other site 1348662001171 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1348662001172 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1348662001173 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1348662001174 active site 1348662001175 catalytic residues [active] 1348662001176 DNA binding site [nucleotide binding] 1348662001177 Int/Topo IB signature motif; other site 1348662001178 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 1348662001179 Recombinase; Region: Recombinase; pfam07508 1348662001180 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1348662001181 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1348662001182 metal-binding site [ion binding] 1348662001183 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1348662001184 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1348662001185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1348662001186 motif I; other site 1348662001187 motif II; other site 1348662001188 Domain of unknown function (DUF305); Region: DUF305; cl17794 1348662001189 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1348662001190 Integrase core domain; Region: rve_3; cl15866 1348662001191 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1348662001192 xanthine permease; Region: pbuX; TIGR03173 1348662001193 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1348662001194 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1348662001195 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1348662001196 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 1348662001197 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1348662001198 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1348662001199 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1348662001200 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1348662001201 ATP binding site [chemical binding]; other site 1348662001202 putative Mg++ binding site [ion binding]; other site 1348662001203 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1348662001204 nucleotide binding region [chemical binding]; other site 1348662001205 ATP-binding site [chemical binding]; other site 1348662001206 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1348662001207 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1348662001208 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 1348662001209 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1348662001210 DNA-binding site [nucleotide binding]; DNA binding site 1348662001211 RNA-binding motif; other site 1348662001212 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1348662001213 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1348662001214 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1348662001215 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1348662001216 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1348662001217 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1348662001218 glutamine binding [chemical binding]; other site 1348662001219 catalytic triad [active] 1348662001220 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1348662001221 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1348662001222 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1348662001223 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1348662001224 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1348662001225 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1348662001226 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1348662001227 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1348662001228 catalytic residue [active] 1348662001229 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1348662001230 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1348662001231 dimer interface [polypeptide binding]; other site 1348662001232 active site 1348662001233 citrylCoA binding site [chemical binding]; other site 1348662001234 NADH binding [chemical binding]; other site 1348662001235 cationic pore residues; other site 1348662001236 oxalacetate/citrate binding site [chemical binding]; other site 1348662001237 coenzyme A binding site [chemical binding]; other site 1348662001238 catalytic triad [active] 1348662001239 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1348662001240 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 1348662001241 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1348662001242 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1348662001243 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1348662001244 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1348662001245 active site 1348662001246 catalytic tetrad [active] 1348662001247 enoyl-CoA hydratase; Provisional; Region: PRK06688 1348662001248 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1348662001249 substrate binding site [chemical binding]; other site 1348662001250 oxyanion hole (OAH) forming residues; other site 1348662001251 trimer interface [polypeptide binding]; other site 1348662001252 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1348662001253 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1348662001254 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1348662001255 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1348662001256 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1348662001257 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1348662001258 Na binding site [ion binding]; other site 1348662001259 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1348662001260 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1348662001261 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1348662001262 active site 1348662001263 SAM binding site [chemical binding]; other site 1348662001264 homodimer interface [polypeptide binding]; other site 1348662001265 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1348662001266 catalytic residues [active] 1348662001267 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1348662001268 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1348662001269 active site 1348662001270 DNA binding site [nucleotide binding] 1348662001271 Int/Topo IB signature motif; other site 1348662001272 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1348662001273 DNA binding residues [nucleotide binding] 1348662001274 ERF superfamily; Region: ERF; pfam04404 1348662001275 HNH endonuclease; Region: HNH; pfam01844 1348662001276 active site 1348662001277 Helix-turn-helix domain; Region: HTH_36; pfam13730 1348662001278 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1348662001279 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1348662001280 putative DNA binding site [nucleotide binding]; other site 1348662001281 dimerization interface [polypeptide binding]; other site 1348662001282 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1348662001283 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1348662001284 ssDNA binding site [nucleotide binding]; other site 1348662001285 dimer interface [polypeptide binding]; other site 1348662001286 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1348662001287 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1348662001288 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1348662001289 DNA methylase; Region: N6_N4_Mtase; pfam01555 1348662001290 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1348662001291 trimer interface [polypeptide binding]; other site 1348662001292 active site 1348662001293 Phage Terminase; Region: Terminase_1; pfam03354 1348662001294 Phage portal protein; Region: Phage_portal; pfam04860 1348662001295 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1348662001296 AAA domain; Region: AAA_33; pfam13671 1348662001297 AAA domain; Region: AAA_17; pfam13207 1348662001298 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1348662001299 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1348662001300 Phage capsid family; Region: Phage_capsid; pfam05065 1348662001301 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1348662001302 membrane protein P6; Region: PHA01399 1348662001303 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1348662001304 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1348662001305 amidase catalytic site [active] 1348662001306 Zn binding residues [ion binding]; other site 1348662001307 substrate binding site [chemical binding]; other site 1348662001308 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1348662001309 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1348662001310 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1348662001311 folate binding site [chemical binding]; other site 1348662001312 NADP+ binding site [chemical binding]; other site 1348662001313 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1348662001314 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1348662001315 dimerization interface [polypeptide binding]; other site 1348662001316 active site 1348662001317 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1348662001318 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1348662001319 active site 1348662001320 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1348662001321 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1348662001322 ATP binding site [chemical binding]; other site 1348662001323 putative Mg++ binding site [ion binding]; other site 1348662001324 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1348662001325 nucleotide binding region [chemical binding]; other site 1348662001326 ATP-binding site [chemical binding]; other site 1348662001327 DEAD/H associated; Region: DEAD_assoc; pfam08494 1348662001328 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1348662001329 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1348662001330 putative DNA binding site [nucleotide binding]; other site 1348662001331 catalytic residue [active] 1348662001332 putative H2TH interface [polypeptide binding]; other site 1348662001333 putative catalytic residues [active] 1348662001334 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1348662001335 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1348662001336 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1348662001337 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1348662001338 active site 1348662001339 dimer interface [polypeptide binding]; other site 1348662001340 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1348662001341 dimer interface [polypeptide binding]; other site 1348662001342 active site 1348662001343 hypothetical protein; Provisional; Region: PRK07857 1348662001344 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1348662001345 Part of AAA domain; Region: AAA_19; pfam13245 1348662001346 Family description; Region: UvrD_C_2; pfam13538 1348662001347 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1348662001348 Peptidase family M23; Region: Peptidase_M23; pfam01551 1348662001349 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1348662001350 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1348662001351 active site 1348662001352 substrate binding site [chemical binding]; other site 1348662001353 cosubstrate binding site; other site 1348662001354 catalytic site [active] 1348662001355 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1348662001356 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1348662001357 purine monophosphate binding site [chemical binding]; other site 1348662001358 dimer interface [polypeptide binding]; other site 1348662001359 putative catalytic residues [active] 1348662001360 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1348662001361 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1348662001362 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1348662001363 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1348662001364 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1348662001365 30S ribosomal protein S18; Provisional; Region: PRK13401 1348662001366 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1348662001367 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1348662001368 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1348662001369 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1348662001370 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1348662001371 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1348662001372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1348662001373 active site 1348662001374 phosphorylation site [posttranslational modification] 1348662001375 intermolecular recognition site; other site 1348662001376 dimerization interface [polypeptide binding]; other site 1348662001377 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1348662001378 DNA binding site [nucleotide binding] 1348662001379 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1348662001380 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1348662001381 dimerization interface [polypeptide binding]; other site 1348662001382 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1348662001383 dimer interface [polypeptide binding]; other site 1348662001384 phosphorylation site [posttranslational modification] 1348662001385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1348662001386 ATP binding site [chemical binding]; other site 1348662001387 Mg2+ binding site [ion binding]; other site 1348662001388 G-X-G motif; other site 1348662001389 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1348662001390 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1348662001391 protein binding site [polypeptide binding]; other site 1348662001392 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1348662001393 MPT binding site; other site 1348662001394 trimer interface [polypeptide binding]; other site 1348662001395 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1348662001396 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1348662001397 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1348662001398 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1348662001399 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1348662001400 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1348662001401 active site 1348662001402 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1348662001403 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1348662001404 dimer interface [polypeptide binding]; other site 1348662001405 putative functional site; other site 1348662001406 putative MPT binding site; other site 1348662001407 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1348662001408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1348662001409 Predicted membrane protein [Function unknown]; Region: COG2259 1348662001410 Predicted integral membrane protein [Function unknown]; Region: COG5660 1348662001411 Putative zinc-finger; Region: zf-HC2; pfam13490 1348662001412 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1348662001413 Predicted methyltransferases [General function prediction only]; Region: COG0313 1348662001414 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1348662001415 putative SAM binding site [chemical binding]; other site 1348662001416 putative homodimer interface [polypeptide binding]; other site 1348662001417 BCCT family transporter; Region: BCCT; pfam02028 1348662001418 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1348662001419 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1348662001420 active site 1348662001421 HIGH motif; other site 1348662001422 KMSKS motif; other site 1348662001423 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1348662001424 tRNA binding surface [nucleotide binding]; other site 1348662001425 anticodon binding site; other site 1348662001426 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1348662001427 active site 1348662001428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1348662001429 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1348662001430 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1348662001431 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1348662001432 G5 domain; Region: G5; pfam07501 1348662001433 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1348662001434 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1348662001435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1348662001436 S-adenosylmethionine binding site [chemical binding]; other site 1348662001437 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1348662001438 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1348662001439 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1348662001440 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1348662001441 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 1348662001442 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 1348662001443 tetramer interface [polypeptide binding]; other site 1348662001444 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 1348662001445 tetramer interface [polypeptide binding]; other site 1348662001446 active site 1348662001447 metal binding site [ion binding]; metal-binding site 1348662001448 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1348662001449 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1348662001450 NAD binding site [chemical binding]; other site 1348662001451 catalytic residues [active] 1348662001452 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1348662001453 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1348662001454 DNA-binding site [nucleotide binding]; DNA binding site 1348662001455 FCD domain; Region: FCD; pfam07729 1348662001456 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1348662001457 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1348662001458 metabolite-proton symporter; Region: 2A0106; TIGR00883 1348662001459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662001460 putative substrate translocation pore; other site 1348662001461 phenol 2-monooxygenase; Provisional; Region: PRK08294 1348662001462 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1348662001463 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 1348662001464 dimer interface [polypeptide binding]; other site 1348662001465 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1348662001466 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1348662001467 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1348662001468 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1348662001469 NAD(P) binding site [chemical binding]; other site 1348662001470 catalytic residues [active] 1348662001471 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1348662001472 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1348662001473 dimer interface [polypeptide binding]; other site 1348662001474 PYR/PP interface [polypeptide binding]; other site 1348662001475 TPP binding site [chemical binding]; other site 1348662001476 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1348662001477 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1348662001478 TPP-binding site [chemical binding]; other site 1348662001479 dimer interface [polypeptide binding]; other site 1348662001480 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1348662001481 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1348662001482 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1348662001483 Cupin domain; Region: Cupin_2; cl17218 1348662001484 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1348662001485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1348662001486 S-adenosylmethionine binding site [chemical binding]; other site 1348662001487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1348662001488 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1348662001489 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1348662001490 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1348662001491 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1348662001492 substrate binding site [chemical binding]; other site 1348662001493 oxyanion hole (OAH) forming residues; other site 1348662001494 trimer interface [polypeptide binding]; other site 1348662001495 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1348662001496 Putative esterase; Region: Esterase; pfam00756 1348662001497 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 1348662001498 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1348662001499 G1 box; other site 1348662001500 putative GEF interaction site [polypeptide binding]; other site 1348662001501 GTP/Mg2+ binding site [chemical binding]; other site 1348662001502 Switch I region; other site 1348662001503 G2 box; other site 1348662001504 G3 box; other site 1348662001505 Switch II region; other site 1348662001506 G4 box; other site 1348662001507 G5 box; other site 1348662001508 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1348662001509 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1348662001510 putative active site [active] 1348662001511 catalytic residue [active] 1348662001512 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1348662001513 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1348662001514 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1348662001515 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1348662001516 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 1348662001517 putative ligand binding residues [chemical binding]; other site 1348662001518 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1348662001519 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1348662001520 ABC-ATPase subunit interface; other site 1348662001521 dimer interface [polypeptide binding]; other site 1348662001522 putative PBP binding regions; other site 1348662001523 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1348662001524 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1348662001525 Walker A/P-loop; other site 1348662001526 ATP binding site [chemical binding]; other site 1348662001527 Q-loop/lid; other site 1348662001528 ABC transporter signature motif; other site 1348662001529 Walker B; other site 1348662001530 D-loop; other site 1348662001531 H-loop/switch region; other site 1348662001532 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1348662001533 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1348662001534 metal binding site [ion binding]; metal-binding site 1348662001535 dimer interface [polypeptide binding]; other site 1348662001536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662001537 metabolite-proton symporter; Region: 2A0106; TIGR00883 1348662001538 putative substrate translocation pore; other site 1348662001539 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 1348662001540 GIY-YIG motif/motif A; other site 1348662001541 active site 1348662001542 catalytic site [active] 1348662001543 metal binding site [ion binding]; metal-binding site 1348662001544 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1348662001545 ABC transporter; Region: ABC_tran; pfam00005 1348662001546 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1348662001547 putative active site [active] 1348662001548 putative metal binding site [ion binding]; other site 1348662001549 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1348662001550 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1348662001551 putative DNA binding site [nucleotide binding]; other site 1348662001552 putative Zn2+ binding site [ion binding]; other site 1348662001553 Bacterial transcriptional regulator; Region: IclR; pfam01614 1348662001554 urocanate hydratase; Provisional; Region: PRK05414 1348662001555 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1348662001556 imidazolonepropionase; Provisional; Region: PRK14085 1348662001557 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1348662001558 active site 1348662001559 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1348662001560 active sites [active] 1348662001561 tetramer interface [polypeptide binding]; other site 1348662001562 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1348662001563 putative active site [active] 1348662001564 catalytic residue [active] 1348662001565 pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953 1348662001566 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1348662001567 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1348662001568 catalytic residues [active] 1348662001569 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1348662001570 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1348662001571 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1348662001572 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1348662001573 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1348662001574 catalytic residues [active] 1348662001575 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1348662001576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1348662001577 active site 1348662001578 phosphorylation site [posttranslational modification] 1348662001579 intermolecular recognition site; other site 1348662001580 dimerization interface [polypeptide binding]; other site 1348662001581 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1348662001582 DNA binding site [nucleotide binding] 1348662001583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1348662001584 dimer interface [polypeptide binding]; other site 1348662001585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1348662001586 phosphorylation site [posttranslational modification] 1348662001587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1348662001588 ATP binding site [chemical binding]; other site 1348662001589 Mg2+ binding site [ion binding]; other site 1348662001590 G-X-G motif; other site 1348662001591 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1348662001592 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1348662001593 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 1348662001594 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1348662001595 putative active site [active] 1348662001596 Fe(II) binding site [ion binding]; other site 1348662001597 putative dimer interface [polypeptide binding]; other site 1348662001598 putative tetramer interface [polypeptide binding]; other site 1348662001599 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1348662001600 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1348662001601 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1348662001602 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1348662001603 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1348662001604 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1348662001605 active site 1348662001606 catalytic residues [active] 1348662001607 metal binding site [ion binding]; metal-binding site 1348662001608 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1348662001609 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 1348662001610 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1348662001611 iron-sulfur cluster [ion binding]; other site 1348662001612 [2Fe-2S] cluster binding site [ion binding]; other site 1348662001613 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 1348662001614 beta subunit interface [polypeptide binding]; other site 1348662001615 alpha subunit interface [polypeptide binding]; other site 1348662001616 active site 1348662001617 substrate binding site [chemical binding]; other site 1348662001618 Fe binding site [ion binding]; other site 1348662001619 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1348662001620 [2Fe-2S] cluster binding site [ion binding]; other site 1348662001621 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1348662001622 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1348662001623 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1348662001624 inter-subunit interface; other site 1348662001625 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 1348662001626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1348662001627 NAD(P) binding site [chemical binding]; other site 1348662001628 active site 1348662001629 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1348662001630 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1348662001631 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1348662001632 acyl-activating enzyme (AAE) consensus motif; other site 1348662001633 putative AMP binding site [chemical binding]; other site 1348662001634 putative active site [active] 1348662001635 putative CoA binding site [chemical binding]; other site 1348662001636 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1348662001637 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1348662001638 CoenzymeA binding site [chemical binding]; other site 1348662001639 subunit interaction site [polypeptide binding]; other site 1348662001640 PHB binding site; other site 1348662001641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662001642 metabolite-proton symporter; Region: 2A0106; TIGR00883 1348662001643 putative substrate translocation pore; other site 1348662001644 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1348662001645 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1348662001646 active site 1348662001647 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1348662001648 active site 1348662001649 metal binding site [ion binding]; metal-binding site 1348662001650 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1348662001651 inter-subunit interface; other site 1348662001652 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1348662001653 iron-sulfur cluster [ion binding]; other site 1348662001654 [2Fe-2S] cluster binding site [ion binding]; other site 1348662001655 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 1348662001656 beta subunit interface [polypeptide binding]; other site 1348662001657 alpha subunit interface [polypeptide binding]; other site 1348662001658 active site 1348662001659 substrate binding site [chemical binding]; other site 1348662001660 Fe binding site [ion binding]; other site 1348662001661 Bacterial transcriptional regulator; Region: IclR; pfam01614 1348662001662 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 1348662001663 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1348662001664 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1348662001665 5S rRNA interface [nucleotide binding]; other site 1348662001666 CTC domain interface [polypeptide binding]; other site 1348662001667 L16 interface [polypeptide binding]; other site 1348662001668 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1348662001669 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1348662001670 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1348662001671 active site 1348662001672 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1348662001673 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1348662001674 Substrate binding site; other site 1348662001675 Mg++ binding site; other site 1348662001676 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1348662001677 active site 1348662001678 substrate binding site [chemical binding]; other site 1348662001679 CoA binding site [chemical binding]; other site 1348662001680 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1348662001681 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1348662001682 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1348662001683 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1348662001684 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1348662001685 ATP binding site [chemical binding]; other site 1348662001686 putative Mg++ binding site [ion binding]; other site 1348662001687 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1348662001688 nucleotide binding region [chemical binding]; other site 1348662001689 ATP-binding site [chemical binding]; other site 1348662001690 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1348662001691 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1348662001692 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1348662001693 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 1348662001694 Imelysin; Region: Peptidase_M75; pfam09375 1348662001695 Iron permease FTR1 family; Region: FTR1; cl00475 1348662001696 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1348662001697 homodimer interface [polypeptide binding]; other site 1348662001698 metal binding site [ion binding]; metal-binding site 1348662001699 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1348662001700 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1348662001701 enolase; Provisional; Region: eno; PRK00077 1348662001702 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1348662001703 dimer interface [polypeptide binding]; other site 1348662001704 metal binding site [ion binding]; metal-binding site 1348662001705 substrate binding pocket [chemical binding]; other site 1348662001706 Septum formation initiator; Region: DivIC; pfam04977 1348662001707 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1348662001708 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1348662001709 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1348662001710 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1348662001711 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1348662001712 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1348662001713 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1348662001714 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1348662001715 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1348662001716 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1348662001717 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1348662001718 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1348662001719 catalytic residue [active] 1348662001720 putative FPP diphosphate binding site; other site 1348662001721 putative FPP binding hydrophobic cleft; other site 1348662001722 dimer interface [polypeptide binding]; other site 1348662001723 putative IPP diphosphate binding site; other site 1348662001724 pantothenate kinase; Provisional; Region: PRK05439 1348662001725 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1348662001726 ATP-binding site [chemical binding]; other site 1348662001727 CoA-binding site [chemical binding]; other site 1348662001728 Mg2+-binding site [ion binding]; other site 1348662001729 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1348662001730 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1348662001731 dimer interface [polypeptide binding]; other site 1348662001732 active site 1348662001733 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1348662001734 folate binding site [chemical binding]; other site 1348662001735 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1348662001736 LGFP repeat; Region: LGFP; pfam08310 1348662001737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662001738 putative substrate translocation pore; other site 1348662001739 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1348662001740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662001741 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1348662001742 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1348662001743 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1348662001744 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1348662001745 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1348662001746 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1348662001747 putative active site [active] 1348662001748 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1348662001749 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1348662001750 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1348662001751 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1348662001752 DNA-binding site [nucleotide binding]; DNA binding site 1348662001753 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1348662001754 Class II fumarases; Region: Fumarase_classII; cd01362 1348662001755 active site 1348662001756 tetramer interface [polypeptide binding]; other site 1348662001757 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1348662001758 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1348662001759 putative active site [active] 1348662001760 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1348662001761 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1348662001762 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1348662001763 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1348662001764 generic binding surface II; other site 1348662001765 generic binding surface I; other site 1348662001766 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1348662001767 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1348662001768 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1348662001769 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1348662001770 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1348662001771 Na2 binding site [ion binding]; other site 1348662001772 putative substrate binding site 1 [chemical binding]; other site 1348662001773 Na binding site 1 [ion binding]; other site 1348662001774 putative substrate binding site 2 [chemical binding]; other site 1348662001775 GTP-binding protein YchF; Reviewed; Region: PRK09601 1348662001776 YchF GTPase; Region: YchF; cd01900 1348662001777 G1 box; other site 1348662001778 GTP/Mg2+ binding site [chemical binding]; other site 1348662001779 Switch I region; other site 1348662001780 G2 box; other site 1348662001781 Switch II region; other site 1348662001782 G3 box; other site 1348662001783 G4 box; other site 1348662001784 G5 box; other site 1348662001785 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1348662001786 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1348662001787 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1348662001788 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1348662001789 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1348662001790 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1348662001791 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1348662001792 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1348662001793 dimerization interface [polypeptide binding]; other site 1348662001794 putative DNA binding site [nucleotide binding]; other site 1348662001795 putative Zn2+ binding site [ion binding]; other site 1348662001796 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1348662001797 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1348662001798 non-specific DNA binding site [nucleotide binding]; other site 1348662001799 salt bridge; other site 1348662001800 sequence-specific DNA binding site [nucleotide binding]; other site 1348662001801 Protein of unknown function (DUF808); Region: DUF808; cl01002 1348662001802 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1348662001803 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1348662001804 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1348662001805 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1348662001806 Walker A/P-loop; other site 1348662001807 ATP binding site [chemical binding]; other site 1348662001808 Q-loop/lid; other site 1348662001809 ABC transporter signature motif; other site 1348662001810 Walker B; other site 1348662001811 D-loop; other site 1348662001812 H-loop/switch region; other site 1348662001813 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1348662001814 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1348662001815 Walker A/P-loop; other site 1348662001816 ATP binding site [chemical binding]; other site 1348662001817 Q-loop/lid; other site 1348662001818 ABC transporter signature motif; other site 1348662001819 Walker B; other site 1348662001820 D-loop; other site 1348662001821 H-loop/switch region; other site 1348662001822 Cobalt transport protein; Region: CbiQ; cl00463 1348662001823 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1348662001824 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1348662001825 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1348662001826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1348662001827 dimer interface [polypeptide binding]; other site 1348662001828 conserved gate region; other site 1348662001829 putative PBP binding loops; other site 1348662001830 ABC-ATPase subunit interface; other site 1348662001831 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1348662001832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1348662001833 dimer interface [polypeptide binding]; other site 1348662001834 conserved gate region; other site 1348662001835 putative PBP binding loops; other site 1348662001836 ABC-ATPase subunit interface; other site 1348662001837 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1348662001838 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1348662001839 Walker A/P-loop; other site 1348662001840 ATP binding site [chemical binding]; other site 1348662001841 Q-loop/lid; other site 1348662001842 ABC transporter signature motif; other site 1348662001843 Walker B; other site 1348662001844 D-loop; other site 1348662001845 H-loop/switch region; other site 1348662001846 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1348662001847 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1348662001848 Walker A/P-loop; other site 1348662001849 ATP binding site [chemical binding]; other site 1348662001850 Q-loop/lid; other site 1348662001851 ABC transporter signature motif; other site 1348662001852 Walker B; other site 1348662001853 D-loop; other site 1348662001854 H-loop/switch region; other site 1348662001855 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1348662001856 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1348662001857 Protein of unknown function (DUF402); Region: DUF402; cl00979 1348662001858 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1348662001859 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1348662001860 G1 box; other site 1348662001861 putative GEF interaction site [polypeptide binding]; other site 1348662001862 GTP/Mg2+ binding site [chemical binding]; other site 1348662001863 Switch I region; other site 1348662001864 G2 box; other site 1348662001865 G3 box; other site 1348662001866 Switch II region; other site 1348662001867 G4 box; other site 1348662001868 G5 box; other site 1348662001869 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1348662001870 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1348662001871 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1348662001872 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1348662001873 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1348662001874 Ferredoxin [Energy production and conversion]; Region: COG1146 1348662001875 4Fe-4S binding domain; Region: Fer4; pfam00037 1348662001876 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1348662001877 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1348662001878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1348662001879 homodimer interface [polypeptide binding]; other site 1348662001880 catalytic residue [active] 1348662001881 Predicted membrane protein [Function unknown]; Region: COG2246 1348662001882 GtrA-like protein; Region: GtrA; pfam04138 1348662001883 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1348662001884 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1348662001885 putative trimer interface [polypeptide binding]; other site 1348662001886 putative CoA binding site [chemical binding]; other site 1348662001887 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1348662001888 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1348662001889 Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171 1348662001890 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1348662001891 putative trimer interface [polypeptide binding]; other site 1348662001892 putative CoA binding site [chemical binding]; other site 1348662001893 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1348662001894 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1348662001895 metal binding site [ion binding]; metal-binding site 1348662001896 putative dimer interface [polypeptide binding]; other site 1348662001897 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1348662001898 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1348662001899 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1348662001900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1348662001901 S-adenosylmethionine binding site [chemical binding]; other site 1348662001902 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1348662001903 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1348662001904 active site 1348662001905 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1348662001906 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1348662001907 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1348662001908 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1348662001909 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1348662001910 ligand binding site; other site 1348662001911 oligomer interface; other site 1348662001912 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1348662001913 dimer interface [polypeptide binding]; other site 1348662001914 N-terminal domain interface [polypeptide binding]; other site 1348662001915 sulfate 1 binding site; other site 1348662001916 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1348662001917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1348662001918 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1348662001919 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1348662001920 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1348662001921 DNA binding residues [nucleotide binding] 1348662001922 Putative zinc-finger; Region: zf-HC2; pfam13490 1348662001923 sec-independent translocase; Provisional; Region: tatB; PRK00182 1348662001924 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1348662001925 Domain of unknown function DUF59; Region: DUF59; pfam01883 1348662001926 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1348662001927 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1348662001928 Predicted membrane protein [Function unknown]; Region: COG4420 1348662001929 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1348662001930 MgtE intracellular N domain; Region: MgtE_N; smart00924 1348662001931 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1348662001932 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1348662001933 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1348662001934 oligomer interface [polypeptide binding]; other site 1348662001935 metal binding site [ion binding]; metal-binding site 1348662001936 metal binding site [ion binding]; metal-binding site 1348662001937 putative Cl binding site [ion binding]; other site 1348662001938 basic sphincter; other site 1348662001939 hydrophobic gate; other site 1348662001940 periplasmic entrance; other site 1348662001941 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1348662001942 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1348662001943 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1348662001944 TPP-binding site [chemical binding]; other site 1348662001945 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1348662001946 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1348662001947 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1348662001948 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1348662001949 Walker A/P-loop; other site 1348662001950 ATP binding site [chemical binding]; other site 1348662001951 Q-loop/lid; other site 1348662001952 ABC transporter signature motif; other site 1348662001953 Walker B; other site 1348662001954 D-loop; other site 1348662001955 H-loop/switch region; other site 1348662001956 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1348662001957 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1348662001958 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1348662001959 Walker A/P-loop; other site 1348662001960 ATP binding site [chemical binding]; other site 1348662001961 Q-loop/lid; other site 1348662001962 ABC transporter signature motif; other site 1348662001963 Walker B; other site 1348662001964 D-loop; other site 1348662001965 H-loop/switch region; other site 1348662001966 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1348662001967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662001968 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1348662001969 putative substrate translocation pore; other site 1348662001970 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1348662001971 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1348662001972 ATP binding site [chemical binding]; other site 1348662001973 Mg++ binding site [ion binding]; other site 1348662001974 motif III; other site 1348662001975 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1348662001976 nucleotide binding region [chemical binding]; other site 1348662001977 ATP-binding site [chemical binding]; other site 1348662001978 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1348662001979 putative RNA binding site [nucleotide binding]; other site 1348662001980 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1348662001981 SNF2 Helicase protein; Region: DUF3670; pfam12419 1348662001982 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1348662001983 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1348662001984 ATP binding site [chemical binding]; other site 1348662001985 putative Mg++ binding site [ion binding]; other site 1348662001986 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1348662001987 nucleotide binding region [chemical binding]; other site 1348662001988 ATP-binding site [chemical binding]; other site 1348662001989 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1348662001990 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1348662001991 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1348662001992 active site 1348662001993 metal binding site [ion binding]; metal-binding site 1348662001994 DNA binding site [nucleotide binding] 1348662001995 AAA domain; Region: AAA_23; pfam13476 1348662001996 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1348662001997 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1348662001998 MarR family; Region: MarR_2; pfam12802 1348662001999 MarR family; Region: MarR_2; cl17246 1348662002000 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1348662002001 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1348662002002 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1348662002003 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1348662002004 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1348662002005 Cysteine-rich domain; Region: CCG; pfam02754 1348662002006 Cysteine-rich domain; Region: CCG; pfam02754 1348662002007 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1348662002008 L-lactate permease; Region: Lactate_perm; cl00701 1348662002009 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1348662002010 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1348662002011 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1348662002012 active site 1348662002013 HIGH motif; other site 1348662002014 KMSK motif region; other site 1348662002015 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1348662002016 tRNA binding surface [nucleotide binding]; other site 1348662002017 anticodon binding site; other site 1348662002018 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1348662002019 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1348662002020 active site 1348662002021 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1348662002022 substrate binding site [chemical binding]; other site 1348662002023 catalytic residues [active] 1348662002024 dimer interface [polypeptide binding]; other site 1348662002025 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1348662002026 Ligand binding site [chemical binding]; other site 1348662002027 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1348662002028 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1348662002029 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1348662002030 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1348662002031 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1348662002032 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1348662002033 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1348662002034 catalytic residue [active] 1348662002035 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1348662002036 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1348662002037 Ligand Binding Site [chemical binding]; other site 1348662002038 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1348662002039 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1348662002040 Lipase (class 2); Region: Lipase_2; pfam01674 1348662002041 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1348662002042 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1348662002043 active site 1348662002044 catalytic site [active] 1348662002045 substrate binding site [chemical binding]; other site 1348662002046 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1348662002047 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1348662002048 nucleotide binding pocket [chemical binding]; other site 1348662002049 K-X-D-G motif; other site 1348662002050 catalytic site [active] 1348662002051 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1348662002052 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1348662002053 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1348662002054 Dimer interface [polypeptide binding]; other site 1348662002055 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1348662002056 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1348662002057 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1348662002058 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1348662002059 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1348662002060 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1348662002061 ABC-ATPase subunit interface; other site 1348662002062 dimer interface [polypeptide binding]; other site 1348662002063 putative PBP binding regions; other site 1348662002064 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1348662002065 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1348662002066 Walker A/P-loop; other site 1348662002067 ATP binding site [chemical binding]; other site 1348662002068 Q-loop/lid; other site 1348662002069 ABC transporter signature motif; other site 1348662002070 Walker B; other site 1348662002071 D-loop; other site 1348662002072 H-loop/switch region; other site 1348662002073 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1348662002074 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1348662002075 intersubunit interface [polypeptide binding]; other site 1348662002076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662002077 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1348662002078 putative substrate translocation pore; other site 1348662002079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662002080 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1348662002081 phosphofructokinase; Region: PFK_mixed; TIGR02483 1348662002082 active site 1348662002083 ADP/pyrophosphate binding site [chemical binding]; other site 1348662002084 dimerization interface [polypeptide binding]; other site 1348662002085 allosteric effector site; other site 1348662002086 fructose-1,6-bisphosphate binding site; other site 1348662002087 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1348662002088 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1348662002089 GatB domain; Region: GatB_Yqey; smart00845 1348662002090 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1348662002091 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1348662002092 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1348662002093 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1348662002094 dimerization interface [polypeptide binding]; other site 1348662002095 Predicted membrane protein [Function unknown]; Region: COG2259 1348662002096 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1348662002097 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1348662002098 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1348662002099 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1348662002100 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1348662002101 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1348662002102 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1348662002103 PYR/PP interface [polypeptide binding]; other site 1348662002104 dimer interface [polypeptide binding]; other site 1348662002105 TPP binding site [chemical binding]; other site 1348662002106 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1348662002107 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1348662002108 TPP-binding site [chemical binding]; other site 1348662002109 dimer interface [polypeptide binding]; other site 1348662002110 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1348662002111 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1348662002112 putative valine binding site [chemical binding]; other site 1348662002113 dimer interface [polypeptide binding]; other site 1348662002114 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1348662002115 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1348662002116 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1348662002117 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1348662002118 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1348662002119 putative homotetramer interface [polypeptide binding]; other site 1348662002120 putative homodimer interface [polypeptide binding]; other site 1348662002121 putative allosteric switch controlling residues; other site 1348662002122 putative metal binding site [ion binding]; other site 1348662002123 putative homodimer-homodimer interface [polypeptide binding]; other site 1348662002124 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1348662002125 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1348662002126 Protein of unknown function DUF262; Region: DUF262; pfam03235 1348662002127 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1348662002128 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1348662002129 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1348662002130 ligand binding site [chemical binding]; other site 1348662002131 NAD binding site [chemical binding]; other site 1348662002132 dimerization interface [polypeptide binding]; other site 1348662002133 catalytic site [active] 1348662002134 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1348662002135 putative L-serine binding site [chemical binding]; other site 1348662002136 OsmC-like protein; Region: OsmC; pfam02566 1348662002137 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1348662002138 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1348662002139 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1348662002140 tartrate dehydrogenase; Region: TTC; TIGR02089 1348662002141 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1348662002142 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1348662002143 ligand binding site [chemical binding]; other site 1348662002144 flexible hinge region; other site 1348662002145 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1348662002146 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1348662002147 metal binding triad; other site 1348662002148 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1348662002149 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1348662002150 active site 1348662002151 catalytic site [active] 1348662002152 substrate binding site [chemical binding]; other site 1348662002153 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1348662002154 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1348662002155 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1348662002156 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1348662002157 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1348662002158 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1348662002159 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1348662002160 active site 1348662002161 HIGH motif; other site 1348662002162 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1348662002163 active site 1348662002164 KMSKS motif; other site 1348662002165 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1348662002166 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1348662002167 Bacterial transcriptional regulator; Region: IclR; pfam01614 1348662002168 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1348662002169 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1348662002170 substrate binding site [chemical binding]; other site 1348662002171 ligand binding site [chemical binding]; other site 1348662002172 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1348662002173 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1348662002174 substrate binding site [chemical binding]; other site 1348662002175 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1348662002176 active site 1348662002177 Ap6A binding site [chemical binding]; other site 1348662002178 nudix motif; other site 1348662002179 metal binding site [ion binding]; metal-binding site 1348662002180 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1348662002181 catalytic core [active] 1348662002182 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1348662002183 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1348662002184 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1348662002185 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1348662002186 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1348662002187 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1348662002188 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1348662002189 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1348662002190 thiamine monophosphate kinase; Provisional; Region: PRK05731 1348662002191 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1348662002192 ATP binding site [chemical binding]; other site 1348662002193 dimerization interface [polypeptide binding]; other site 1348662002194 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1348662002195 ligand binding site [chemical binding]; other site 1348662002196 active site 1348662002197 UGI interface [polypeptide binding]; other site 1348662002198 catalytic site [active] 1348662002199 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1348662002200 DAK2 domain; Region: Dak2; pfam02734 1348662002201 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1348662002202 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1348662002203 generic binding surface II; other site 1348662002204 ssDNA binding site; other site 1348662002205 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1348662002206 ATP binding site [chemical binding]; other site 1348662002207 putative Mg++ binding site [ion binding]; other site 1348662002208 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1348662002209 nucleotide binding region [chemical binding]; other site 1348662002210 ATP-binding site [chemical binding]; other site 1348662002211 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1348662002212 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1348662002213 carboxyltransferase (CT) interaction site; other site 1348662002214 biotinylation site [posttranslational modification]; other site 1348662002215 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1348662002216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1348662002217 S-adenosylmethionine binding site [chemical binding]; other site 1348662002218 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1348662002219 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1348662002220 active site 1348662002221 (T/H)XGH motif; other site 1348662002222 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1348662002223 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1348662002224 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1348662002225 Walker A/P-loop; other site 1348662002226 ATP binding site [chemical binding]; other site 1348662002227 Q-loop/lid; other site 1348662002228 ABC transporter signature motif; other site 1348662002229 Walker B; other site 1348662002230 D-loop; other site 1348662002231 H-loop/switch region; other site 1348662002232 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1348662002233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1348662002234 dimer interface [polypeptide binding]; other site 1348662002235 conserved gate region; other site 1348662002236 putative PBP binding loops; other site 1348662002237 ABC-ATPase subunit interface; other site 1348662002238 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1348662002239 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1348662002240 substrate binding pocket [chemical binding]; other site 1348662002241 membrane-bound complex binding site; other site 1348662002242 hinge residues; other site 1348662002243 DNA polymerase I; Provisional; Region: PRK05755 1348662002244 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1348662002245 active site 1348662002246 metal binding site 1 [ion binding]; metal-binding site 1348662002247 putative 5' ssDNA interaction site; other site 1348662002248 metal binding site 3; metal-binding site 1348662002249 metal binding site 2 [ion binding]; metal-binding site 1348662002250 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1348662002251 putative DNA binding site [nucleotide binding]; other site 1348662002252 putative metal binding site [ion binding]; other site 1348662002253 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1348662002254 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1348662002255 active site 1348662002256 DNA binding site [nucleotide binding] 1348662002257 catalytic site [active] 1348662002258 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1348662002259 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1348662002260 RNA binding site [nucleotide binding]; other site 1348662002261 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1348662002262 RNA binding site [nucleotide binding]; other site 1348662002263 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1348662002264 RNA binding site [nucleotide binding]; other site 1348662002265 S1 RNA binding domain; Region: S1; pfam00575 1348662002266 RNA binding site [nucleotide binding]; other site 1348662002267 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1348662002268 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1348662002269 active site turn [active] 1348662002270 phosphorylation site [posttranslational modification] 1348662002271 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1348662002272 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1348662002273 HPr interaction site; other site 1348662002274 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1348662002275 active site 1348662002276 phosphorylation site [posttranslational modification] 1348662002277 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1348662002278 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1348662002279 CoA-binding site [chemical binding]; other site 1348662002280 ATP-binding [chemical binding]; other site 1348662002281 excinuclease ABC subunit B; Provisional; Region: PRK05298 1348662002282 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1348662002283 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1348662002284 nucleotide binding region [chemical binding]; other site 1348662002285 ATP-binding site [chemical binding]; other site 1348662002286 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1348662002287 UvrB/uvrC motif; Region: UVR; pfam02151 1348662002288 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1348662002289 Ligand Binding Site [chemical binding]; other site 1348662002290 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1348662002291 Part of AAA domain; Region: AAA_19; pfam13245 1348662002292 Family description; Region: UvrD_C_2; pfam13538 1348662002293 DoxX; Region: DoxX; cl17842 1348662002294 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1348662002295 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1348662002296 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1348662002297 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1348662002298 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1348662002299 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1348662002300 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1348662002301 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1348662002302 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1348662002303 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1348662002304 23S rRNA binding site [nucleotide binding]; other site 1348662002305 L21 binding site [polypeptide binding]; other site 1348662002306 L13 binding site [polypeptide binding]; other site 1348662002307 TM2 domain; Region: TM2; pfam05154 1348662002308 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1348662002309 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1348662002310 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1348662002311 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1348662002312 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1348662002313 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1348662002314 dimer interface [polypeptide binding]; other site 1348662002315 motif 1; other site 1348662002316 active site 1348662002317 motif 2; other site 1348662002318 motif 3; other site 1348662002319 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1348662002320 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1348662002321 putative tRNA-binding site [nucleotide binding]; other site 1348662002322 B3/4 domain; Region: B3_4; pfam03483 1348662002323 tRNA synthetase B5 domain; Region: B5; smart00874 1348662002324 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1348662002325 dimer interface [polypeptide binding]; other site 1348662002326 motif 1; other site 1348662002327 motif 3; other site 1348662002328 motif 2; other site 1348662002329 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1348662002330 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1348662002331 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1348662002332 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1348662002333 heterotetramer interface [polypeptide binding]; other site 1348662002334 active site pocket [active] 1348662002335 cleavage site 1348662002336 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1348662002337 feedback inhibition sensing region; other site 1348662002338 homohexameric interface [polypeptide binding]; other site 1348662002339 nucleotide binding site [chemical binding]; other site 1348662002340 N-acetyl-L-glutamate binding site [chemical binding]; other site 1348662002341 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1348662002342 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1348662002343 inhibitor-cofactor binding pocket; inhibition site 1348662002344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1348662002345 catalytic residue [active] 1348662002346 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1348662002347 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1348662002348 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1348662002349 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1348662002350 Arginine repressor [Transcription]; Region: ArgR; COG1438 1348662002351 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1348662002352 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1348662002353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662002354 putative substrate translocation pore; other site 1348662002355 argininosuccinate synthase; Provisional; Region: PRK13820 1348662002356 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1348662002357 ANP binding site [chemical binding]; other site 1348662002358 Substrate Binding Site II [chemical binding]; other site 1348662002359 Substrate Binding Site I [chemical binding]; other site 1348662002360 argininosuccinate lyase; Provisional; Region: PRK00855 1348662002361 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1348662002362 active sites [active] 1348662002363 tetramer interface [polypeptide binding]; other site 1348662002364 aminotransferase; Validated; Region: PRK07777 1348662002365 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1348662002366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1348662002367 homodimer interface [polypeptide binding]; other site 1348662002368 catalytic residue [active] 1348662002369 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1348662002370 TPP-binding site [chemical binding]; other site 1348662002371 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1348662002372 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1348662002373 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1348662002374 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1348662002375 active site 1348662002376 HIGH motif; other site 1348662002377 dimer interface [polypeptide binding]; other site 1348662002378 KMSKS motif; other site 1348662002379 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1348662002380 RNA binding surface [nucleotide binding]; other site 1348662002381 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1348662002382 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1348662002383 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1348662002384 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1348662002385 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1348662002386 RNA binding surface [nucleotide binding]; other site 1348662002387 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1348662002388 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1348662002389 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1348662002390 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1348662002391 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1348662002392 Walker A/P-loop; other site 1348662002393 ATP binding site [chemical binding]; other site 1348662002394 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1348662002395 ABC transporter signature motif; other site 1348662002396 Walker B; other site 1348662002397 D-loop; other site 1348662002398 H-loop/switch region; other site 1348662002399 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1348662002400 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 1348662002401 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1348662002402 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1348662002403 dimer interface [polypeptide binding]; other site 1348662002404 ADP-ribose binding site [chemical binding]; other site 1348662002405 active site 1348662002406 nudix motif; other site 1348662002407 metal binding site [ion binding]; metal-binding site 1348662002408 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1348662002409 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1348662002410 active site 1348662002411 Int/Topo IB signature motif; other site 1348662002412 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1348662002413 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1348662002414 P-loop; other site 1348662002415 Magnesium ion binding site [ion binding]; other site 1348662002416 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1348662002417 Magnesium ion binding site [ion binding]; other site 1348662002418 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1348662002419 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1348662002420 3-mercaptopyruvate sulfurtransferase; Region: PLN02723 1348662002421 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1348662002422 active site residue [active] 1348662002423 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1348662002424 active site residue [active] 1348662002425 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1348662002426 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 1348662002427 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1348662002428 inhibitor-cofactor binding pocket; inhibition site 1348662002429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1348662002430 catalytic residue [active] 1348662002431 AAA domain; Region: AAA_26; pfam13500 1348662002432 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1348662002433 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1348662002434 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1348662002435 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1348662002436 RNA binding surface [nucleotide binding]; other site 1348662002437 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1348662002438 active site 1348662002439 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 1348662002440 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1348662002441 CMP-binding site; other site 1348662002442 The sites determining sugar specificity; other site 1348662002443 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1348662002444 G1 box; other site 1348662002445 GTP/Mg2+ binding site [chemical binding]; other site 1348662002446 Switch I region; other site 1348662002447 G2 box; other site 1348662002448 Switch II region; other site 1348662002449 G3 box; other site 1348662002450 G4 box; other site 1348662002451 G5 box; other site 1348662002452 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1348662002453 G1 box; other site 1348662002454 GTP/Mg2+ binding site [chemical binding]; other site 1348662002455 Switch I region; other site 1348662002456 G2 box; other site 1348662002457 G3 box; other site 1348662002458 Switch II region; other site 1348662002459 G4 box; other site 1348662002460 G5 box; other site 1348662002461 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1348662002462 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1348662002463 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1348662002464 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1348662002465 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1348662002466 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1348662002467 nucleotide binding region [chemical binding]; other site 1348662002468 ATP-binding site [chemical binding]; other site 1348662002469 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1348662002470 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1348662002471 phosphopeptide binding site; other site 1348662002472 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1348662002473 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1348662002474 DNA binding residues [nucleotide binding] 1348662002475 dimer interface [polypeptide binding]; other site 1348662002476 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1348662002477 DNA binding residues [nucleotide binding] 1348662002478 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1348662002479 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1348662002480 Domain of unknown function DUF21; Region: DUF21; pfam01595 1348662002481 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1348662002482 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1348662002483 Domain of unknown function DUF21; Region: DUF21; pfam01595 1348662002484 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1348662002485 Transporter associated domain; Region: CorC_HlyC; smart01091 1348662002486 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1348662002487 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1348662002488 ATP binding site [chemical binding]; other site 1348662002489 putative Mg++ binding site [ion binding]; other site 1348662002490 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1348662002491 nucleotide binding region [chemical binding]; other site 1348662002492 ATP-binding site [chemical binding]; other site 1348662002493 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1348662002494 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1348662002495 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1348662002496 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1348662002497 CoenzymeA binding site [chemical binding]; other site 1348662002498 subunit interaction site [polypeptide binding]; other site 1348662002499 PHB binding site; other site 1348662002500 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1348662002501 thiamine phosphate binding site [chemical binding]; other site 1348662002502 active site 1348662002503 pyrophosphate binding site [ion binding]; other site 1348662002504 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1348662002505 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1348662002506 catalytic residue [active] 1348662002507 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1348662002508 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 1348662002509 ATP binding site [chemical binding]; other site 1348662002510 substrate interface [chemical binding]; other site 1348662002511 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1348662002512 ThiS interaction site; other site 1348662002513 putative active site [active] 1348662002514 tetramer interface [polypeptide binding]; other site 1348662002515 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1348662002516 thiS-thiF/thiG interaction site; other site 1348662002517 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1348662002518 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1348662002519 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 1348662002520 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1348662002521 dimer interface [polypeptide binding]; other site 1348662002522 substrate binding site [chemical binding]; other site 1348662002523 ATP binding site [chemical binding]; other site 1348662002524 Putative transcription activator [Transcription]; Region: TenA; COG0819 1348662002525 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1348662002526 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1348662002527 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1348662002528 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1348662002529 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1348662002530 FAD binding domain; Region: FAD_binding_4; pfam01565 1348662002531 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1348662002532 Cysteine-rich domain; Region: CCG; pfam02754 1348662002533 metabolite-proton symporter; Region: 2A0106; TIGR00883 1348662002534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662002535 putative substrate translocation pore; other site 1348662002536 YceI-like domain; Region: YceI; pfam04264 1348662002537 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1348662002538 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1348662002539 Ligand binding site; other site 1348662002540 Putative Catalytic site; other site 1348662002541 DXD motif; other site 1348662002542 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1348662002543 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1348662002544 putative active site [active] 1348662002545 catalytic triad [active] 1348662002546 putative dimer interface [polypeptide binding]; other site 1348662002547 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1348662002548 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1348662002549 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1348662002550 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1348662002551 precorrin-3B synthase; Region: CobG; TIGR02435 1348662002552 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1348662002553 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1348662002554 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1348662002555 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1348662002556 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1348662002557 active site 1348662002558 SAM binding site [chemical binding]; other site 1348662002559 homodimer interface [polypeptide binding]; other site 1348662002560 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1348662002561 active site 1348662002562 SAM binding site [chemical binding]; other site 1348662002563 homodimer interface [polypeptide binding]; other site 1348662002564 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1348662002565 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1348662002566 active site 1348662002567 SAM binding site [chemical binding]; other site 1348662002568 homodimer interface [polypeptide binding]; other site 1348662002569 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1348662002570 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1348662002571 active site 1348662002572 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1348662002573 putative homodimer interface [polypeptide binding]; other site 1348662002574 active site 1348662002575 SAM binding site [chemical binding]; other site 1348662002576 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1348662002577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1348662002578 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1348662002579 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1348662002580 ATP binding site [chemical binding]; other site 1348662002581 putative Mg++ binding site [ion binding]; other site 1348662002582 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1348662002583 nucleotide binding region [chemical binding]; other site 1348662002584 ATP-binding site [chemical binding]; other site 1348662002585 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1348662002586 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1348662002587 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1348662002588 WYL domain; Region: WYL; pfam13280 1348662002589 Predicted transcriptional regulator [Transcription]; Region: COG2378 1348662002590 WYL domain; Region: WYL; pfam13280 1348662002591 Pup-ligase protein; Region: Pup_ligase; cl15463 1348662002592 Pup-like protein; Region: Pup; pfam05639 1348662002593 Htaa; Region: HtaA; pfam04213 1348662002594 Pup-ligase protein; Region: Pup_ligase; cl15463 1348662002595 proteasome ATPase; Region: pup_AAA; TIGR03689 1348662002596 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1348662002597 Walker A motif; other site 1348662002598 ATP binding site [chemical binding]; other site 1348662002599 Walker B motif; other site 1348662002600 arginine finger; other site 1348662002601 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1348662002602 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1348662002603 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1348662002604 intersubunit interface [polypeptide binding]; other site 1348662002605 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1348662002606 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1348662002607 ABC-ATPase subunit interface; other site 1348662002608 dimer interface [polypeptide binding]; other site 1348662002609 putative PBP binding regions; other site 1348662002610 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1348662002611 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1348662002612 ABC-ATPase subunit interface; other site 1348662002613 dimer interface [polypeptide binding]; other site 1348662002614 putative PBP binding regions; other site 1348662002615 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1348662002616 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1348662002617 Walker A/P-loop; other site 1348662002618 ATP binding site [chemical binding]; other site 1348662002619 Q-loop/lid; other site 1348662002620 ABC transporter signature motif; other site 1348662002621 Walker B; other site 1348662002622 D-loop; other site 1348662002623 H-loop/switch region; other site 1348662002624 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1348662002625 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1348662002626 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1348662002627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1348662002628 S-adenosylmethionine binding site [chemical binding]; other site 1348662002629 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1348662002630 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1348662002631 active site 1348662002632 metal binding site [ion binding]; metal-binding site 1348662002633 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1348662002634 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1348662002635 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1348662002636 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1348662002637 Aspartase; Region: Aspartase; cd01357 1348662002638 active sites [active] 1348662002639 tetramer interface [polypeptide binding]; other site 1348662002640 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1348662002641 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1348662002642 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1348662002643 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1348662002644 homodimer interface [polypeptide binding]; other site 1348662002645 putative metal binding site [ion binding]; other site 1348662002646 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1348662002647 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1348662002648 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1348662002649 motif II; other site 1348662002650 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1348662002651 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1348662002652 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1348662002653 substrate binding pocket [chemical binding]; other site 1348662002654 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1348662002655 B12 binding site [chemical binding]; other site 1348662002656 cobalt ligand [ion binding]; other site 1348662002657 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1348662002658 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1348662002659 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1348662002660 active site 1348662002661 HIGH motif; other site 1348662002662 nucleotide binding site [chemical binding]; other site 1348662002663 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1348662002664 active site 1348662002665 KMSKS motif; other site 1348662002666 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1348662002667 tRNA binding surface [nucleotide binding]; other site 1348662002668 anticodon binding site; other site 1348662002669 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1348662002670 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1348662002671 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1348662002672 active site 1348662002673 catalytic tetrad [active] 1348662002674 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1348662002675 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1348662002676 quinone interaction residues [chemical binding]; other site 1348662002677 active site 1348662002678 catalytic residues [active] 1348662002679 FMN binding site [chemical binding]; other site 1348662002680 substrate binding site [chemical binding]; other site 1348662002681 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1348662002682 substrate binding site [chemical binding]; other site 1348662002683 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1348662002684 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1348662002685 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1348662002686 Walker A/P-loop; other site 1348662002687 ATP binding site [chemical binding]; other site 1348662002688 Q-loop/lid; other site 1348662002689 ABC transporter signature motif; other site 1348662002690 Walker B; other site 1348662002691 D-loop; other site 1348662002692 H-loop/switch region; other site 1348662002693 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1348662002694 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1348662002695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1348662002696 ABC transporter signature motif; other site 1348662002697 Walker B; other site 1348662002698 D-loop; other site 1348662002699 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1348662002700 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1348662002701 Walker A; other site 1348662002702 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1348662002703 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1348662002704 active site 1348662002705 substrate binding site [chemical binding]; other site 1348662002706 coenzyme B12 binding site [chemical binding]; other site 1348662002707 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1348662002708 B12 binding site [chemical binding]; other site 1348662002709 cobalt ligand [ion binding]; other site 1348662002710 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1348662002711 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1348662002712 heterodimer interface [polypeptide binding]; other site 1348662002713 substrate interaction site [chemical binding]; other site 1348662002714 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1348662002715 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1348662002716 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1348662002717 MarR family; Region: MarR_2; cl17246 1348662002718 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1348662002719 ferrochelatase; Reviewed; Region: hemH; PRK00035 1348662002720 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1348662002721 C-terminal domain interface [polypeptide binding]; other site 1348662002722 active site 1348662002723 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1348662002724 active site 1348662002725 N-terminal domain interface [polypeptide binding]; other site 1348662002726 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1348662002727 NlpC/P60 family; Region: NLPC_P60; pfam00877 1348662002728 ATPase (PilT family) [General function prediction only]; Region: COG1855 1348662002729 aconitate hydratase; Validated; Region: PRK09277 1348662002730 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1348662002731 substrate binding site [chemical binding]; other site 1348662002732 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1348662002733 ligand binding site [chemical binding]; other site 1348662002734 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1348662002735 substrate binding site [chemical binding]; other site 1348662002736 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1348662002737 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1348662002738 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1348662002739 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1348662002740 catalytic triad [active] 1348662002741 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1348662002742 catalytic triad [active] 1348662002743 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 1348662002744 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1348662002745 Na2 binding site [ion binding]; other site 1348662002746 putative substrate binding site 1 [chemical binding]; other site 1348662002747 Na binding site 1 [ion binding]; other site 1348662002748 putative substrate binding site 2 [chemical binding]; other site 1348662002749 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1348662002750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1348662002751 Walker A/P-loop; other site 1348662002752 ATP binding site [chemical binding]; other site 1348662002753 Q-loop/lid; other site 1348662002754 ABC transporter signature motif; other site 1348662002755 Walker B; other site 1348662002756 D-loop; other site 1348662002757 H-loop/switch region; other site 1348662002758 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1348662002759 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1348662002760 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1348662002761 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1348662002762 trimerization site [polypeptide binding]; other site 1348662002763 active site 1348662002764 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1348662002765 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1348662002766 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1348662002767 catalytic residue [active] 1348662002768 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1348662002769 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1348662002770 Walker A/P-loop; other site 1348662002771 ATP binding site [chemical binding]; other site 1348662002772 Q-loop/lid; other site 1348662002773 ABC transporter signature motif; other site 1348662002774 Walker B; other site 1348662002775 D-loop; other site 1348662002776 H-loop/switch region; other site 1348662002777 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1348662002778 FeS assembly protein SufD; Region: sufD; TIGR01981 1348662002779 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1348662002780 FeS assembly protein SufB; Region: sufB; TIGR01980 1348662002781 Predicted transcriptional regulator [Transcription]; Region: COG2345 1348662002782 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1348662002783 putative DNA binding site [nucleotide binding]; other site 1348662002784 putative Zn2+ binding site [ion binding]; other site 1348662002785 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1348662002786 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1348662002787 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1348662002788 Walker A/P-loop; other site 1348662002789 ATP binding site [chemical binding]; other site 1348662002790 Q-loop/lid; other site 1348662002791 ABC transporter signature motif; other site 1348662002792 Walker B; other site 1348662002793 D-loop; other site 1348662002794 H-loop/switch region; other site 1348662002795 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1348662002796 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1348662002797 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1348662002798 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1348662002799 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1348662002800 NADP binding site [chemical binding]; other site 1348662002801 dimer interface [polypeptide binding]; other site 1348662002802 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1348662002803 UbiA prenyltransferase family; Region: UbiA; pfam01040 1348662002804 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1348662002805 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1348662002806 TPP-binding site [chemical binding]; other site 1348662002807 dimer interface [polypeptide binding]; other site 1348662002808 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1348662002809 PYR/PP interface [polypeptide binding]; other site 1348662002810 dimer interface [polypeptide binding]; other site 1348662002811 TPP binding site [chemical binding]; other site 1348662002812 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1348662002813 putative active site [active] 1348662002814 transaldolase; Provisional; Region: PRK03903 1348662002815 catalytic residue [active] 1348662002816 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1348662002817 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1348662002818 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1348662002819 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1348662002820 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1348662002821 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1348662002822 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1348662002823 putative active site [active] 1348662002824 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1348662002825 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1348662002826 Walker A/P-loop; other site 1348662002827 ATP binding site [chemical binding]; other site 1348662002828 Q-loop/lid; other site 1348662002829 ABC transporter signature motif; other site 1348662002830 Walker B; other site 1348662002831 D-loop; other site 1348662002832 H-loop/switch region; other site 1348662002833 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1348662002834 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1348662002835 FtsX-like permease family; Region: FtsX; pfam02687 1348662002836 FtsX-like permease family; Region: FtsX; pfam02687 1348662002837 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1348662002838 triosephosphate isomerase; Provisional; Region: PRK14567 1348662002839 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1348662002840 substrate binding site [chemical binding]; other site 1348662002841 dimer interface [polypeptide binding]; other site 1348662002842 catalytic triad [active] 1348662002843 Phosphoglycerate kinase; Region: PGK; pfam00162 1348662002844 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1348662002845 substrate binding site [chemical binding]; other site 1348662002846 hinge regions; other site 1348662002847 ADP binding site [chemical binding]; other site 1348662002848 catalytic site [active] 1348662002849 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1348662002850 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1348662002851 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1348662002852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1348662002853 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1348662002854 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1348662002855 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1348662002856 phosphate binding site [ion binding]; other site 1348662002857 putative substrate binding pocket [chemical binding]; other site 1348662002858 dimer interface [polypeptide binding]; other site 1348662002859 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1348662002860 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1348662002861 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1348662002862 GIY-YIG motif/motif A; other site 1348662002863 active site 1348662002864 catalytic site [active] 1348662002865 putative DNA binding site [nucleotide binding]; other site 1348662002866 metal binding site [ion binding]; metal-binding site 1348662002867 UvrB/uvrC motif; Region: UVR; pfam02151 1348662002868 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1348662002869 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1348662002870 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1348662002871 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1348662002872 substrate binding site [chemical binding]; other site 1348662002873 hexamer interface [polypeptide binding]; other site 1348662002874 metal binding site [ion binding]; metal-binding site 1348662002875 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1348662002876 NusB family; Region: NusB; pfam01029 1348662002877 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1348662002878 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1348662002879 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1348662002880 putative active site [active] 1348662002881 substrate binding site [chemical binding]; other site 1348662002882 putative cosubstrate binding site; other site 1348662002883 catalytic site [active] 1348662002884 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1348662002885 substrate binding site [chemical binding]; other site 1348662002886 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1348662002887 active site 1348662002888 catalytic residues [active] 1348662002889 metal binding site [ion binding]; metal-binding site 1348662002890 primosome assembly protein PriA; Provisional; Region: PRK14873 1348662002891 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1348662002892 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1348662002893 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1348662002894 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1348662002895 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1348662002896 Flavoprotein; Region: Flavoprotein; pfam02441 1348662002897 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1348662002898 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 1348662002899 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1348662002900 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1348662002901 catalytic site [active] 1348662002902 Predicted permeases [General function prediction only]; Region: COG0679 1348662002903 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1348662002904 active site 1348662002905 dimer interface [polypeptide binding]; other site 1348662002906 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1348662002907 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1348662002908 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1348662002909 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1348662002910 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1348662002911 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1348662002912 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1348662002913 IMP binding site; other site 1348662002914 dimer interface [polypeptide binding]; other site 1348662002915 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1348662002916 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1348662002917 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1348662002918 catalytic site [active] 1348662002919 subunit interface [polypeptide binding]; other site 1348662002920 dihydroorotase; Validated; Region: pyrC; PRK09357 1348662002921 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1348662002922 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1348662002923 active site 1348662002924 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1348662002925 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1348662002926 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1348662002927 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1348662002928 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1348662002929 active site 1348662002930 hydrophobic ligand binding site; other site 1348662002931 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1348662002932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1348662002933 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1348662002934 NAD(P) binding site [chemical binding]; other site 1348662002935 active site 1348662002936 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1348662002937 transcription antitermination factor NusB; Region: nusB; TIGR01951 1348662002938 elongation factor P; Validated; Region: PRK00529 1348662002939 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1348662002940 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1348662002941 RNA binding site [nucleotide binding]; other site 1348662002942 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1348662002943 RNA binding site [nucleotide binding]; other site 1348662002944 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1348662002945 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1348662002946 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1348662002947 active site 1348662002948 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1348662002949 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1348662002950 trimer interface [polypeptide binding]; other site 1348662002951 active site 1348662002952 dimer interface [polypeptide binding]; other site 1348662002953 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1348662002954 active site 1348662002955 dimer interface [polypeptide binding]; other site 1348662002956 metal binding site [ion binding]; metal-binding site 1348662002957 shikimate kinase; Reviewed; Region: aroK; PRK00131 1348662002958 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1348662002959 ADP binding site [chemical binding]; other site 1348662002960 magnesium binding site [ion binding]; other site 1348662002961 putative shikimate binding site; other site 1348662002962 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1348662002963 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1348662002964 Tetramer interface [polypeptide binding]; other site 1348662002965 active site 1348662002966 FMN-binding site [chemical binding]; other site 1348662002967 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1348662002968 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1348662002969 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1348662002970 shikimate binding site; other site 1348662002971 NAD(P) binding site [chemical binding]; other site 1348662002972 YceG-like family; Region: YceG; pfam02618 1348662002973 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 1348662002974 dimerization interface [polypeptide binding]; other site 1348662002975 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1348662002976 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1348662002977 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1348662002978 motif 1; other site 1348662002979 active site 1348662002980 motif 2; other site 1348662002981 motif 3; other site 1348662002982 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1348662002983 recombination factor protein RarA; Reviewed; Region: PRK13342 1348662002984 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1348662002985 Walker A motif; other site 1348662002986 ATP binding site [chemical binding]; other site 1348662002987 Walker B motif; other site 1348662002988 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1348662002989 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1348662002990 substrate binding site [chemical binding]; other site 1348662002991 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1348662002992 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1348662002993 dimer interface [polypeptide binding]; other site 1348662002994 anticodon binding site; other site 1348662002995 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1348662002996 homodimer interface [polypeptide binding]; other site 1348662002997 motif 1; other site 1348662002998 active site 1348662002999 motif 2; other site 1348662003000 GAD domain; Region: GAD; pfam02938 1348662003001 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1348662003002 active site 1348662003003 motif 3; other site 1348662003004 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1348662003005 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1348662003006 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1348662003007 ATP binding site [chemical binding]; other site 1348662003008 putative Mg++ binding site [ion binding]; other site 1348662003009 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1348662003010 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1348662003011 nucleotide binding region [chemical binding]; other site 1348662003012 ATP-binding site [chemical binding]; other site 1348662003013 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1348662003014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1348662003015 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1348662003016 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1348662003017 motif 1; other site 1348662003018 dimer interface [polypeptide binding]; other site 1348662003019 active site 1348662003020 motif 2; other site 1348662003021 motif 3; other site 1348662003022 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1348662003023 anticodon binding site; other site 1348662003024 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1348662003025 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1348662003026 active site 1348662003027 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1348662003028 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1348662003029 Zn2+ binding site [ion binding]; other site 1348662003030 Mg2+ binding site [ion binding]; other site 1348662003031 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1348662003032 synthetase active site [active] 1348662003033 NTP binding site [chemical binding]; other site 1348662003034 metal binding site [ion binding]; metal-binding site 1348662003035 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1348662003036 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1348662003037 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1348662003038 active site 1348662003039 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1348662003040 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1348662003041 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1348662003042 Protein export membrane protein; Region: SecD_SecF; pfam02355 1348662003043 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1348662003044 Protein export membrane protein; Region: SecD_SecF; cl14618 1348662003045 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1348662003046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1348662003047 Walker A motif; other site 1348662003048 ATP binding site [chemical binding]; other site 1348662003049 Walker B motif; other site 1348662003050 arginine finger; other site 1348662003051 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1348662003052 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1348662003053 RuvA N terminal domain; Region: RuvA_N; pfam01330 1348662003054 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1348662003055 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1348662003056 active site 1348662003057 putative DNA-binding cleft [nucleotide binding]; other site 1348662003058 dimer interface [polypeptide binding]; other site 1348662003059 hypothetical protein; Validated; Region: PRK00110 1348662003060 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1348662003061 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; Region: IMP_synth_hisH; TIGR01855 1348662003062 predicted active site [active] 1348662003063 catalytic triad [active] 1348662003064 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1348662003065 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1348662003066 active site 1348662003067 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1348662003068 catalytic triad [active] 1348662003069 dimer interface [polypeptide binding]; other site 1348662003070 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1348662003071 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1348662003072 active site 1348662003073 multimer interface [polypeptide binding]; other site 1348662003074 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1348662003075 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1348662003076 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1348662003077 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1348662003078 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1348662003079 putative acyl-acceptor binding pocket; other site 1348662003080 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1348662003081 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1348662003082 nucleotide binding site/active site [active] 1348662003083 HIT family signature motif; other site 1348662003084 catalytic residue [active] 1348662003085 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1348662003086 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1348662003087 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1348662003088 active site 1348662003089 dimer interface [polypeptide binding]; other site 1348662003090 motif 1; other site 1348662003091 motif 2; other site 1348662003092 motif 3; other site 1348662003093 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1348662003094 anticodon binding site; other site 1348662003095 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1348662003096 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1348662003097 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1348662003098 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1348662003099 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 1348662003100 SelR domain; Region: SelR; pfam01641 1348662003101 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1348662003102 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1348662003103 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1348662003104 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1348662003105 TPP-binding site; other site 1348662003106 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1348662003107 PYR/PP interface [polypeptide binding]; other site 1348662003108 dimer interface [polypeptide binding]; other site 1348662003109 TPP binding site [chemical binding]; other site 1348662003110 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1348662003111 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1348662003112 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1348662003113 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1348662003114 trimer interface [polypeptide binding]; other site 1348662003115 active site 1348662003116 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1348662003117 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1348662003118 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1348662003119 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1348662003120 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1348662003121 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1348662003122 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1348662003123 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1348662003124 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1348662003125 DNA binding residues [nucleotide binding] 1348662003126 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1348662003127 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1348662003128 ATP binding site [chemical binding]; other site 1348662003129 putative Mg++ binding site [ion binding]; other site 1348662003130 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1348662003131 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1348662003132 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1348662003133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1348662003134 S-adenosylmethionine binding site [chemical binding]; other site 1348662003135 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1348662003136 putative active site [active] 1348662003137 dimerization interface [polypeptide binding]; other site 1348662003138 putative tRNAtyr binding site [nucleotide binding]; other site 1348662003139 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1348662003140 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1348662003141 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1348662003142 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1348662003143 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1348662003144 DNA binding residues [nucleotide binding] 1348662003145 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1348662003146 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1348662003147 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1348662003148 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1348662003149 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1348662003150 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1348662003151 NAD binding site [chemical binding]; other site 1348662003152 homodimer interface [polypeptide binding]; other site 1348662003153 active site 1348662003154 substrate binding site [chemical binding]; other site 1348662003155 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1348662003156 PAC2 family; Region: PAC2; pfam09754 1348662003157 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1348662003158 ATP binding site [chemical binding]; other site 1348662003159 putative Mg++ binding site [ion binding]; other site 1348662003160 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1348662003161 nucleotide binding region [chemical binding]; other site 1348662003162 ATP-binding site [chemical binding]; other site 1348662003163 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1348662003164 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1348662003165 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1348662003166 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1348662003167 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1348662003168 dimer interface [polypeptide binding]; other site 1348662003169 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1348662003170 catalytic triad [active] 1348662003171 peroxidatic and resolving cysteines [active] 1348662003172 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1348662003173 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1348662003174 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1348662003175 dimerization interface [polypeptide binding]; other site 1348662003176 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1348662003177 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1348662003178 ATP binding site [chemical binding]; other site 1348662003179 putative Mg++ binding site [ion binding]; other site 1348662003180 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1348662003181 nucleotide binding region [chemical binding]; other site 1348662003182 ATP-binding site [chemical binding]; other site 1348662003183 Helicase associated domain (HA2); Region: HA2; pfam04408 1348662003184 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1348662003185 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1348662003186 ATP cone domain; Region: ATP-cone; pfam03477 1348662003187 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1348662003188 Catalytic site [active] 1348662003189 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1348662003190 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1348662003191 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1348662003192 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1348662003193 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1348662003194 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1348662003195 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1348662003196 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1348662003197 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1348662003198 putative substrate binding site [chemical binding]; other site 1348662003199 putative ATP binding site [chemical binding]; other site 1348662003200 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1348662003201 active site 1348662003202 phosphorylation site [posttranslational modification] 1348662003203 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1348662003204 regulatory protein interface [polypeptide binding]; other site 1348662003205 active site 1348662003206 regulatory phosphorylation site [posttranslational modification]; other site 1348662003207 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1348662003208 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1348662003209 dimer interface [polypeptide binding]; other site 1348662003210 catalytic triad [active] 1348662003211 peroxidatic and resolving cysteines [active] 1348662003212 GTPases [General function prediction only]; Region: HflX; COG2262 1348662003213 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1348662003214 HflX GTPase family; Region: HflX; cd01878 1348662003215 G1 box; other site 1348662003216 GTP/Mg2+ binding site [chemical binding]; other site 1348662003217 Switch I region; other site 1348662003218 G2 box; other site 1348662003219 G3 box; other site 1348662003220 Switch II region; other site 1348662003221 G4 box; other site 1348662003222 G5 box; other site 1348662003223 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1348662003224 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1348662003225 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1348662003226 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1348662003227 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1348662003228 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1348662003229 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1348662003230 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1348662003231 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1348662003232 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1348662003233 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1348662003234 FeS/SAM binding site; other site 1348662003235 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1348662003236 recombinase A; Provisional; Region: recA; PRK09354 1348662003237 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1348662003238 hexamer interface [polypeptide binding]; other site 1348662003239 Walker A motif; other site 1348662003240 ATP binding site [chemical binding]; other site 1348662003241 Walker B motif; other site 1348662003242 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1348662003243 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1348662003244 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1348662003245 non-specific DNA binding site [nucleotide binding]; other site 1348662003246 salt bridge; other site 1348662003247 sequence-specific DNA binding site [nucleotide binding]; other site 1348662003248 Competence-damaged protein; Region: CinA; pfam02464 1348662003249 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1348662003250 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1348662003251 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1348662003252 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1348662003253 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1348662003254 TIGR03085 family protein; Region: TIGR03085 1348662003255 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1348662003256 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1348662003257 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1348662003258 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1348662003259 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1348662003260 dimer interface [polypeptide binding]; other site 1348662003261 active site 1348662003262 catalytic residue [active] 1348662003263 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1348662003264 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1348662003265 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1348662003266 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1348662003267 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1348662003268 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1348662003269 oligomer interface [polypeptide binding]; other site 1348662003270 RNA binding site [nucleotide binding]; other site 1348662003271 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1348662003272 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1348662003273 RNase E interface [polypeptide binding]; other site 1348662003274 trimer interface [polypeptide binding]; other site 1348662003275 active site 1348662003276 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1348662003277 putative nucleic acid binding region [nucleotide binding]; other site 1348662003278 G-X-X-G motif; other site 1348662003279 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1348662003280 RNA binding site [nucleotide binding]; other site 1348662003281 domain interface; other site 1348662003282 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1348662003283 16S/18S rRNA binding site [nucleotide binding]; other site 1348662003284 S13e-L30e interaction site [polypeptide binding]; other site 1348662003285 25S rRNA binding site [nucleotide binding]; other site 1348662003286 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1348662003287 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1348662003288 active site 1348662003289 Riboflavin kinase; Region: Flavokinase; smart00904 1348662003290 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1348662003291 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1348662003292 RNA binding site [nucleotide binding]; other site 1348662003293 active site 1348662003294 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1348662003295 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1348662003296 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1348662003297 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1348662003298 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1348662003299 active site 1348662003300 metal binding site [ion binding]; metal-binding site 1348662003301 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1348662003302 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1348662003303 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1348662003304 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1348662003305 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1348662003306 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1348662003307 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1348662003308 G1 box; other site 1348662003309 putative GEF interaction site [polypeptide binding]; other site 1348662003310 GTP/Mg2+ binding site [chemical binding]; other site 1348662003311 Switch I region; other site 1348662003312 G2 box; other site 1348662003313 G3 box; other site 1348662003314 Switch II region; other site 1348662003315 G4 box; other site 1348662003316 G5 box; other site 1348662003317 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1348662003318 Translation-initiation factor 2; Region: IF-2; pfam11987 1348662003319 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1348662003320 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 1348662003321 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1348662003322 NusA N-terminal domain; Region: NusA_N; pfam08529 1348662003323 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1348662003324 RNA binding site [nucleotide binding]; other site 1348662003325 homodimer interface [polypeptide binding]; other site 1348662003326 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1348662003327 G-X-X-G motif; other site 1348662003328 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1348662003329 G-X-X-G motif; other site 1348662003330 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1348662003331 Sm and related proteins; Region: Sm_like; cl00259 1348662003332 heptamer interface [polypeptide binding]; other site 1348662003333 Sm1 motif; other site 1348662003334 hexamer interface [polypeptide binding]; other site 1348662003335 RNA binding site [nucleotide binding]; other site 1348662003336 Sm2 motif; other site 1348662003337 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1348662003338 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1348662003339 dimer interface [polypeptide binding]; other site 1348662003340 motif 1; other site 1348662003341 active site 1348662003342 motif 2; other site 1348662003343 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1348662003344 putative deacylase active site [active] 1348662003345 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1348662003346 active site 1348662003347 motif 3; other site 1348662003348 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1348662003349 anticodon binding site; other site 1348662003350 hypothetical protein; Validated; Region: PRK02101 1348662003351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662003352 putative substrate translocation pore; other site 1348662003353 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1348662003354 active site 1348662003355 SAM binding site [chemical binding]; other site 1348662003356 homodimer interface [polypeptide binding]; other site 1348662003357 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1348662003358 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1348662003359 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1348662003360 catalytic triad [active] 1348662003361 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1348662003362 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1348662003363 homodimer interface [polypeptide binding]; other site 1348662003364 Walker A motif; other site 1348662003365 ATP binding site [chemical binding]; other site 1348662003366 hydroxycobalamin binding site [chemical binding]; other site 1348662003367 Walker B motif; other site 1348662003368 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1348662003369 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1348662003370 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1348662003371 LssY C-terminus; Region: LssY_C; pfam14067 1348662003372 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1348662003373 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1348662003374 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 1348662003375 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1348662003376 metal ion-dependent adhesion site (MIDAS); other site 1348662003377 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1348662003378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1348662003379 Walker A motif; other site 1348662003380 ATP binding site [chemical binding]; other site 1348662003381 Walker B motif; other site 1348662003382 arginine finger; other site 1348662003383 malate:quinone oxidoreductase; Validated; Region: PRK05257 1348662003384 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1348662003385 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1348662003386 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1348662003387 mycothione reductase; Reviewed; Region: PRK07846 1348662003388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1348662003389 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1348662003390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662003391 putative substrate translocation pore; other site 1348662003392 cobyric acid synthase; Provisional; Region: PRK00784 1348662003393 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1348662003394 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1348662003395 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1348662003396 catalytic triad [active] 1348662003397 methionine aminopeptidase; Provisional; Region: PRK12318 1348662003398 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1348662003399 active site 1348662003400 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1348662003401 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1348662003402 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1348662003403 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1348662003404 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1348662003405 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1348662003406 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1348662003407 active site 1348662003408 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1348662003409 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1348662003410 putative substrate binding region [chemical binding]; other site 1348662003411 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1348662003412 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1348662003413 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1348662003414 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1348662003415 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1348662003416 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1348662003417 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1348662003418 FeS/SAM binding site; other site 1348662003419 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1348662003420 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1348662003421 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1348662003422 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1348662003423 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1348662003424 hinge region; other site 1348662003425 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1348662003426 putative nucleotide binding site [chemical binding]; other site 1348662003427 uridine monophosphate binding site [chemical binding]; other site 1348662003428 homohexameric interface [polypeptide binding]; other site 1348662003429 elongation factor Ts; Provisional; Region: tsf; PRK09377 1348662003430 UBA/TS-N domain; Region: UBA; pfam00627 1348662003431 Elongation factor TS; Region: EF_TS; pfam00889 1348662003432 Elongation factor TS; Region: EF_TS; pfam00889 1348662003433 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1348662003434 rRNA interaction site [nucleotide binding]; other site 1348662003435 S8 interaction site; other site 1348662003436 putative laminin-1 binding site; other site 1348662003437 Peptidase family M23; Region: Peptidase_M23; pfam01551 1348662003438 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1348662003439 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1348662003440 active site 1348662003441 DNA binding site [nucleotide binding] 1348662003442 Int/Topo IB signature motif; other site 1348662003443 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1348662003444 DNA protecting protein DprA; Region: dprA; TIGR00732 1348662003445 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1348662003446 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1348662003447 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1348662003448 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1348662003449 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1348662003450 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1348662003451 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1348662003452 RNA/DNA hybrid binding site [nucleotide binding]; other site 1348662003453 active site 1348662003454 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1348662003455 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1348662003456 Catalytic site [active] 1348662003457 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1348662003458 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1348662003459 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1348662003460 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1348662003461 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1348662003462 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1348662003463 RNA binding site [nucleotide binding]; other site 1348662003464 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1348662003465 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1348662003466 RimM N-terminal domain; Region: RimM; pfam01782 1348662003467 PRC-barrel domain; Region: PRC; pfam05239 1348662003468 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1348662003469 Sodium Bile acid symporter family; Region: SBF; pfam01758 1348662003470 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1348662003471 signal recognition particle protein; Provisional; Region: PRK10867 1348662003472 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1348662003473 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1348662003474 P loop; other site 1348662003475 GTP binding site [chemical binding]; other site 1348662003476 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1348662003477 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 1348662003478 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1348662003479 metal binding triad; other site 1348662003480 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1348662003481 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1348662003482 Zn2+ binding site [ion binding]; other site 1348662003483 Mg2+ binding site [ion binding]; other site 1348662003484 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1348662003485 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1348662003486 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1348662003487 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1348662003488 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1348662003489 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1348662003490 AAA domain; Region: AAA_23; pfam13476 1348662003491 Walker A/P-loop; other site 1348662003492 ATP binding site [chemical binding]; other site 1348662003493 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1348662003494 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 1348662003495 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1348662003496 ABC transporter signature motif; other site 1348662003497 Walker B; other site 1348662003498 D-loop; other site 1348662003499 H-loop/switch region; other site 1348662003500 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1348662003501 amino acid carrier protein; Region: agcS; TIGR00835 1348662003502 ribonuclease III; Reviewed; Region: rnc; PRK00102 1348662003503 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1348662003504 dimerization interface [polypeptide binding]; other site 1348662003505 active site 1348662003506 metal binding site [ion binding]; metal-binding site 1348662003507 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1348662003508 dsRNA binding site [nucleotide binding]; other site 1348662003509 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1348662003510 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1348662003511 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1348662003512 glutamate dehydrogenase; Provisional; Region: PRK09414 1348662003513 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1348662003514 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1348662003515 NAD(P) binding site [chemical binding]; other site 1348662003516 Lipase (class 2); Region: Lipase_2; pfam01674 1348662003517 Glycerate kinase family; Region: Gly_kinase; cl00841 1348662003518 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1348662003519 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1348662003520 nucleotide binding site/active site [active] 1348662003521 HIT family signature motif; other site 1348662003522 catalytic residue [active] 1348662003523 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1348662003524 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1348662003525 metal binding site [ion binding]; metal-binding site 1348662003526 putative dimer interface [polypeptide binding]; other site 1348662003527 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1348662003528 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1348662003529 Na binding site [ion binding]; other site 1348662003530 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1348662003531 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1348662003532 active site pocket [active] 1348662003533 pyruvate kinase; Provisional; Region: PRK06247 1348662003534 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1348662003535 domain interfaces; other site 1348662003536 active site 1348662003537 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1348662003538 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1348662003539 active site 1348662003540 ribulose/triose binding site [chemical binding]; other site 1348662003541 phosphate binding site [ion binding]; other site 1348662003542 substrate (anthranilate) binding pocket [chemical binding]; other site 1348662003543 product (indole) binding pocket [chemical binding]; other site 1348662003544 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1348662003545 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1348662003546 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1348662003547 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1348662003548 substrate binding site [chemical binding]; other site 1348662003549 glutamase interaction surface [polypeptide binding]; other site 1348662003550 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1348662003551 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1348662003552 catalytic residues [active] 1348662003553 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1348662003554 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1348662003555 putative active site [active] 1348662003556 oxyanion strand; other site 1348662003557 catalytic triad [active] 1348662003558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662003559 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1348662003560 putative substrate translocation pore; other site 1348662003561 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1348662003562 putative active site pocket [active] 1348662003563 4-fold oligomerization interface [polypeptide binding]; other site 1348662003564 metal binding residues [ion binding]; metal-binding site 1348662003565 3-fold/trimer interface [polypeptide binding]; other site 1348662003566 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1348662003567 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1348662003568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1348662003569 homodimer interface [polypeptide binding]; other site 1348662003570 catalytic residue [active] 1348662003571 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1348662003572 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1348662003573 NAD binding site [chemical binding]; other site 1348662003574 dimerization interface [polypeptide binding]; other site 1348662003575 product binding site; other site 1348662003576 substrate binding site [chemical binding]; other site 1348662003577 zinc binding site [ion binding]; other site 1348662003578 catalytic residues [active] 1348662003579 biotin synthase; Validated; Region: PRK06256 1348662003580 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1348662003581 FeS/SAM binding site; other site 1348662003582 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1348662003583 VP2/VP3; Provisional; Region: PHA02616 1348662003584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1348662003585 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1348662003586 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1348662003587 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1348662003588 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1348662003589 active site 1348662003590 catalytic site [active] 1348662003591 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1348662003592 active site 1348662003593 catalytic site [active] 1348662003594 substrate binding site [chemical binding]; other site 1348662003595 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1348662003596 synthetase active site [active] 1348662003597 NTP binding site [chemical binding]; other site 1348662003598 metal binding site [ion binding]; metal-binding site 1348662003599 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis]; Region: COG1188 1348662003600 RNA binding surface [nucleotide binding]; other site 1348662003601 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1348662003602 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1348662003603 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1348662003604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662003605 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1348662003606 putative substrate translocation pore; other site 1348662003607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662003608 threonine dehydratase; Validated; Region: PRK08639 1348662003609 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1348662003610 tetramer interface [polypeptide binding]; other site 1348662003611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1348662003612 catalytic residue [active] 1348662003613 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1348662003614 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1348662003615 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1348662003616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1348662003617 Walker A/P-loop; other site 1348662003618 ATP binding site [chemical binding]; other site 1348662003619 ABC transporter signature motif; other site 1348662003620 Walker B; other site 1348662003621 D-loop; other site 1348662003622 H-loop/switch region; other site 1348662003623 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1348662003624 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1348662003625 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1348662003626 active site 1348662003627 homodimer interface [polypeptide binding]; other site 1348662003628 catalytic site [active] 1348662003629 acceptor binding site [chemical binding]; other site 1348662003630 glycogen branching enzyme; Provisional; Region: PRK05402 1348662003631 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1348662003632 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1348662003633 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1348662003634 active site 1348662003635 catalytic site [active] 1348662003636 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1348662003637 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1348662003638 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1348662003639 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1348662003640 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1348662003641 dimer interface [polypeptide binding]; other site 1348662003642 substrate binding site [chemical binding]; other site 1348662003643 metal binding site [ion binding]; metal-binding site 1348662003644 hypothetical protein; Provisional; Region: PRK03298 1348662003645 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1348662003646 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1348662003647 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 1348662003648 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1348662003649 gamma subunit interface [polypeptide binding]; other site 1348662003650 epsilon subunit interface [polypeptide binding]; other site 1348662003651 LBP interface [polypeptide binding]; other site 1348662003652 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1348662003653 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1348662003654 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1348662003655 alpha subunit interaction interface [polypeptide binding]; other site 1348662003656 Walker A motif; other site 1348662003657 ATP binding site [chemical binding]; other site 1348662003658 Walker B motif; other site 1348662003659 inhibitor binding site; inhibition site 1348662003660 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1348662003661 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1348662003662 core domain interface [polypeptide binding]; other site 1348662003663 delta subunit interface [polypeptide binding]; other site 1348662003664 epsilon subunit interface [polypeptide binding]; other site 1348662003665 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1348662003666 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1348662003667 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1348662003668 beta subunit interaction interface [polypeptide binding]; other site 1348662003669 Walker A motif; other site 1348662003670 ATP binding site [chemical binding]; other site 1348662003671 Walker B motif; other site 1348662003672 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1348662003673 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1348662003674 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1348662003675 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1348662003676 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1348662003677 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1348662003678 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1348662003679 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1348662003680 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1348662003681 Mg++ binding site [ion binding]; other site 1348662003682 putative catalytic motif [active] 1348662003683 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1348662003684 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1348662003685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1348662003686 S-adenosylmethionine binding site [chemical binding]; other site 1348662003687 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1348662003688 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1348662003689 RF-1 domain; Region: RF-1; pfam00472 1348662003690 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1348662003691 transcription termination factor Rho; Provisional; Region: PRK12608 1348662003692 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1348662003693 RNA binding site [nucleotide binding]; other site 1348662003694 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1348662003695 multimer interface [polypeptide binding]; other site 1348662003696 Walker A motif; other site 1348662003697 ATP binding site [chemical binding]; other site 1348662003698 Walker B motif; other site 1348662003699 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 1348662003700 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1348662003701 acyl-activating enzyme (AAE) consensus motif; other site 1348662003702 AMP binding site [chemical binding]; other site 1348662003703 active site 1348662003704 CoA binding site [chemical binding]; other site 1348662003705 homoserine kinase; Provisional; Region: PRK01212 1348662003706 threonine synthase; Reviewed; Region: PRK06721 1348662003707 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1348662003708 homodimer interface [polypeptide binding]; other site 1348662003709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1348662003710 catalytic residue [active] 1348662003711 homoserine dehydrogenase; Provisional; Region: PRK06349 1348662003712 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1348662003713 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1348662003714 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1348662003715 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1348662003716 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1348662003717 dimer interface [polypeptide binding]; other site 1348662003718 active site 1348662003719 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1348662003720 acyl-coenzyme A oxidase; Region: PLN02526 1348662003721 active site 1348662003722 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1348662003723 active site 1348662003724 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1348662003725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1348662003726 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1348662003727 dimerization interface [polypeptide binding]; other site 1348662003728 substrate binding pocket [chemical binding]; other site 1348662003729 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1348662003730 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1348662003731 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1348662003732 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 1348662003733 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1348662003734 substrate binding site [chemical binding]; other site 1348662003735 oxyanion hole (OAH) forming residues; other site 1348662003736 trimer interface [polypeptide binding]; other site 1348662003737 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 1348662003738 DctM-like transporters; Region: DctM; pfam06808 1348662003739 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1348662003740 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1348662003741 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1348662003742 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1348662003743 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1348662003744 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1348662003745 Na binding site [ion binding]; other site 1348662003746 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1348662003747 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1348662003748 active site 1348662003749 PHP Thumb interface [polypeptide binding]; other site 1348662003750 metal binding site [ion binding]; metal-binding site 1348662003751 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1348662003752 generic binding surface II; other site 1348662003753 generic binding surface I; other site 1348662003754 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1348662003755 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1348662003756 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1348662003757 catalytic residue [active] 1348662003758 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1348662003759 EamA-like transporter family; Region: EamA; cl17759 1348662003760 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1348662003761 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1348662003762 RNA binding surface [nucleotide binding]; other site 1348662003763 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1348662003764 active site 1348662003765 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1348662003766 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1348662003767 active site 1348662003768 homotetramer interface [polypeptide binding]; other site 1348662003769 homodimer interface [polypeptide binding]; other site 1348662003770 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1348662003771 active site 1348662003772 catalytic site [active] 1348662003773 substrate binding site [chemical binding]; other site 1348662003774 tellurium resistance terB-like protein; Region: terB_like; cl11965 1348662003775 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1348662003776 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1348662003777 PhnA protein; Region: PhnA; pfam03831 1348662003778 DNA polymerase IV; Provisional; Region: PRK03348 1348662003779 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1348662003780 active site 1348662003781 DNA binding site [nucleotide binding] 1348662003782 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1348662003783 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1348662003784 HIGH motif; other site 1348662003785 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1348662003786 active site 1348662003787 KMSKS motif; other site 1348662003788 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1348662003789 tRNA binding surface [nucleotide binding]; other site 1348662003790 anticodon binding site; other site 1348662003791 DivIVA domain; Region: DivI1A_domain; TIGR03544 1348662003792 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1348662003793 Predicted integral membrane protein [Function unknown]; Region: COG0762 1348662003794 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1348662003795 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1348662003796 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1348662003797 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1348662003798 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1348662003799 nucleotide binding site [chemical binding]; other site 1348662003800 SulA interaction site; other site 1348662003801 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1348662003802 Cell division protein FtsQ; Region: FtsQ; pfam03799 1348662003803 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1348662003804 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1348662003805 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1348662003806 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1348662003807 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1348662003808 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1348662003809 active site 1348662003810 homodimer interface [polypeptide binding]; other site 1348662003811 cell division protein FtsW; Region: ftsW; TIGR02614 1348662003812 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1348662003813 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1348662003814 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1348662003815 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1348662003816 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1348662003817 Mg++ binding site [ion binding]; other site 1348662003818 putative catalytic motif [active] 1348662003819 putative substrate binding site [chemical binding]; other site 1348662003820 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1348662003821 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1348662003822 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1348662003823 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1348662003824 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1348662003825 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1348662003826 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1348662003827 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1348662003828 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1348662003829 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1348662003830 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1348662003831 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1348662003832 MraW methylase family; Region: Methyltransf_5; cl17771 1348662003833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1348662003834 MraZ protein; Region: MraZ; pfam02381 1348662003835 MraZ protein; Region: MraZ; pfam02381 1348662003836 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1348662003837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1348662003838 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1348662003839 Coenzyme A binding pocket [chemical binding]; other site 1348662003840 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1348662003841 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1348662003842 FAD binding site [chemical binding]; other site 1348662003843 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1348662003844 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1348662003845 substrate binding pocket [chemical binding]; other site 1348662003846 chain length determination region; other site 1348662003847 substrate-Mg2+ binding site; other site 1348662003848 catalytic residues [active] 1348662003849 aspartate-rich region 1; other site 1348662003850 active site lid residues [active] 1348662003851 aspartate-rich region 2; other site 1348662003852 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1348662003853 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1348662003854 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1348662003855 active site 1348662003856 ATP binding site [chemical binding]; other site 1348662003857 substrate binding site [chemical binding]; other site 1348662003858 activation loop (A-loop); other site 1348662003859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1348662003860 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1348662003861 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1348662003862 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1348662003863 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1348662003864 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1348662003865 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1348662003866 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1348662003867 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1348662003868 putative acyl-acceptor binding pocket; other site 1348662003869 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1348662003870 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1348662003871 nucleotide binding site [chemical binding]; other site 1348662003872 Tesmin/TSO1-like CXC domain; Region: CXC; pfam03638 1348662003873 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1348662003874 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1348662003875 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1348662003876 NlpC/P60 family; Region: NLPC_P60; pfam00877 1348662003877 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1348662003878 NlpC/P60 family; Region: NLPC_P60; pfam00877 1348662003879 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1348662003880 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1348662003881 Coenzyme A binding pocket [chemical binding]; other site 1348662003882 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1348662003883 heme bH binding site [chemical binding]; other site 1348662003884 intrachain domain interface; other site 1348662003885 heme bL binding site [chemical binding]; other site 1348662003886 interchain domain interface [polypeptide binding]; other site 1348662003887 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1348662003888 Qo binding site; other site 1348662003889 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1348662003890 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1348662003891 iron-sulfur cluster [ion binding]; other site 1348662003892 [2Fe-2S] cluster binding site [ion binding]; other site 1348662003893 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1348662003894 Cytochrome c; Region: Cytochrom_C; pfam00034 1348662003895 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1348662003896 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1348662003897 Subunit I/III interface [polypeptide binding]; other site 1348662003898 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1348662003899 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1348662003900 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1348662003901 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1348662003902 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1348662003903 active site 1348662003904 dimer interface [polypeptide binding]; other site 1348662003905 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1348662003906 Ligand Binding Site [chemical binding]; other site 1348662003907 Molecular Tunnel; other site 1348662003908 Predicted transcriptional regulators [Transcription]; Region: COG1695 1348662003909 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1348662003910 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1348662003911 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1348662003912 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1348662003913 homotrimer interface [polypeptide binding]; other site 1348662003914 Walker A motif; other site 1348662003915 GTP binding site [chemical binding]; other site 1348662003916 Walker B motif; other site 1348662003917 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1348662003918 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1348662003919 putative dimer interface [polypeptide binding]; other site 1348662003920 active site pocket [active] 1348662003921 putative cataytic base [active] 1348662003922 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1348662003923 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1348662003924 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1348662003925 homodimer interface [polypeptide binding]; other site 1348662003926 substrate-cofactor binding pocket; other site 1348662003927 catalytic residue [active] 1348662003928 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1348662003929 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1348662003930 interface (dimer of trimers) [polypeptide binding]; other site 1348662003931 Substrate-binding/catalytic site; other site 1348662003932 Zn-binding sites [ion binding]; other site 1348662003933 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1348662003934 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1348662003935 E3 interaction surface; other site 1348662003936 lipoyl attachment site [posttranslational modification]; other site 1348662003937 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1348662003938 E3 interaction surface; other site 1348662003939 lipoyl attachment site [posttranslational modification]; other site 1348662003940 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1348662003941 E3 interaction surface; other site 1348662003942 lipoyl attachment site [posttranslational modification]; other site 1348662003943 e3 binding domain; Region: E3_binding; pfam02817 1348662003944 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1348662003945 lipoate-protein ligase B; Provisional; Region: PRK14345 1348662003946 lipoyl synthase; Provisional; Region: PRK05481 1348662003947 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1348662003948 FeS/SAM binding site; other site 1348662003949 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1348662003950 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1348662003951 RDD family; Region: RDD; pfam06271 1348662003952 glutamine synthetase, type I; Region: GlnA; TIGR00653 1348662003953 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1348662003954 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1348662003955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662003956 putative substrate translocation pore; other site 1348662003957 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1348662003958 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1348662003959 heme binding pocket [chemical binding]; other site 1348662003960 heme ligand [chemical binding]; other site 1348662003961 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1348662003962 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1348662003963 metal binding triad; other site 1348662003964 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1348662003965 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1348662003966 metal binding triad; other site 1348662003967 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1348662003968 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1348662003969 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1348662003970 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1348662003971 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1348662003972 putative active site; other site 1348662003973 putative metal binding residues [ion binding]; other site 1348662003974 signature motif; other site 1348662003975 putative triphosphate binding site [ion binding]; other site 1348662003976 galactokinase; Provisional; Region: PRK00555 1348662003977 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1348662003978 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1348662003979 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1348662003980 RNA/DNA hybrid binding site [nucleotide binding]; other site 1348662003981 active site 1348662003982 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1348662003983 catalytic core [active] 1348662003984 Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; Region: SynN; cl00143 1348662003985 Putative zinc ribbon domain; Region: DUF164; pfam02591 1348662003986 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1348662003987 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1348662003988 hypothetical protein; Provisional; Region: PRK07908 1348662003989 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1348662003990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1348662003991 homodimer interface [polypeptide binding]; other site 1348662003992 catalytic residue [active] 1348662003993 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1348662003994 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1348662003995 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1348662003996 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1348662003997 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1348662003998 inhibitor-cofactor binding pocket; inhibition site 1348662003999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1348662004000 catalytic residue [active] 1348662004001 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1348662004002 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1348662004003 tetramerization interface [polypeptide binding]; other site 1348662004004 NAD(P) binding site [chemical binding]; other site 1348662004005 catalytic residues [active] 1348662004006 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1348662004007 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1348662004008 benzoate transport; Region: 2A0115; TIGR00895 1348662004009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662004010 putative substrate translocation pore; other site 1348662004011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662004012 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1348662004013 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1348662004014 active site 1348662004015 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1348662004016 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1348662004017 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 1348662004018 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1348662004019 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1348662004020 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1348662004021 active site 1348662004022 Zn binding site [ion binding]; other site 1348662004023 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1348662004024 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1348662004025 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1348662004026 dimer interface [polypeptide binding]; other site 1348662004027 TPP-binding site [chemical binding]; other site 1348662004028 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 1348662004029 putative metal binding residues [ion binding]; other site 1348662004030 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 1348662004031 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 1348662004032 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1348662004033 Serine hydrolase; Region: Ser_hydrolase; cl17834 1348662004034 acyl carrier protein; Provisional; Region: acpP; PRK00982 1348662004035 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1348662004036 Beta-lactamase; Region: Beta-lactamase; pfam00144 1348662004037 Predicted membrane protein [Function unknown]; Region: COG2860 1348662004038 UPF0126 domain; Region: UPF0126; pfam03458 1348662004039 UPF0126 domain; Region: UPF0126; pfam03458 1348662004040 DNA primase; Validated; Region: dnaG; PRK05667 1348662004041 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1348662004042 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1348662004043 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1348662004044 active site 1348662004045 metal binding site [ion binding]; metal-binding site 1348662004046 interdomain interaction site; other site 1348662004047 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1348662004048 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1348662004049 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1348662004050 active site 1348662004051 barstar interaction site; other site 1348662004052 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1348662004053 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1348662004054 Zn2+ binding site [ion binding]; other site 1348662004055 Mg2+ binding site [ion binding]; other site 1348662004056 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1348662004057 Repair protein; Region: Repair_PSII; pfam04536 1348662004058 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1348662004059 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1348662004060 motif 1; other site 1348662004061 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1348662004062 active site 1348662004063 motif 2; other site 1348662004064 motif 3; other site 1348662004065 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1348662004066 anticodon binding site; other site 1348662004067 ferric uptake regulator; Provisional; Region: fur; PRK09462 1348662004068 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1348662004069 metal binding site 2 [ion binding]; metal-binding site 1348662004070 putative DNA binding helix; other site 1348662004071 metal binding site 1 [ion binding]; metal-binding site 1348662004072 dimer interface [polypeptide binding]; other site 1348662004073 structural Zn2+ binding site [ion binding]; other site 1348662004074 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 1348662004075 diiron binding motif [ion binding]; other site 1348662004076 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 1348662004077 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1348662004078 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1348662004079 catalytic residue [active] 1348662004080 putative FPP diphosphate binding site; other site 1348662004081 putative FPP binding hydrophobic cleft; other site 1348662004082 dimer interface [polypeptide binding]; other site 1348662004083 putative IPP diphosphate binding site; other site 1348662004084 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1348662004085 Recombination protein O N terminal; Region: RecO_N; pfam11967 1348662004086 Recombination protein O C terminal; Region: RecO_C; pfam02565 1348662004087 GTPase Era; Reviewed; Region: era; PRK00089 1348662004088 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1348662004089 G1 box; other site 1348662004090 GTP/Mg2+ binding site [chemical binding]; other site 1348662004091 Switch I region; other site 1348662004092 G2 box; other site 1348662004093 Switch II region; other site 1348662004094 G3 box; other site 1348662004095 G4 box; other site 1348662004096 G5 box; other site 1348662004097 KH domain; Region: KH_2; pfam07650 1348662004098 Domain of unknown function DUF21; Region: DUF21; pfam01595 1348662004099 FOG: CBS domain [General function prediction only]; Region: COG0517 1348662004100 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1348662004101 Transporter associated domain; Region: CorC_HlyC; smart01091 1348662004102 metal-binding heat shock protein; Provisional; Region: PRK00016 1348662004103 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1348662004104 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 1348662004105 PhoH-like protein; Region: PhoH; pfam02562 1348662004106 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1348662004107 chaperone protein DnaJ; Provisional; Region: PRK14278 1348662004108 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1348662004109 HSP70 interaction site [polypeptide binding]; other site 1348662004110 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1348662004111 Zn binding sites [ion binding]; other site 1348662004112 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1348662004113 dimer interface [polypeptide binding]; other site 1348662004114 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1348662004115 HTH domain; Region: HTH_11; cl17392 1348662004116 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1348662004117 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1348662004118 FeS/SAM binding site; other site 1348662004119 HemN C-terminal domain; Region: HemN_C; pfam06969 1348662004120 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1348662004121 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1348662004122 acyl-activating enzyme (AAE) consensus motif; other site 1348662004123 putative AMP binding site [chemical binding]; other site 1348662004124 putative active site [active] 1348662004125 putative CoA binding site [chemical binding]; other site 1348662004126 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1348662004127 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1348662004128 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1348662004129 trehalose synthase; Region: treS_nterm; TIGR02456 1348662004130 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1348662004131 active site 1348662004132 catalytic site [active] 1348662004133 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1348662004134 Phosphotransferase enzyme family; Region: APH; pfam01636 1348662004135 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1348662004136 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1348662004137 active site 1348662004138 metal binding site [ion binding]; metal-binding site 1348662004139 nudix motif; other site 1348662004140 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1348662004141 active site lid residues [active] 1348662004142 substrate binding pocket [chemical binding]; other site 1348662004143 catalytic residues [active] 1348662004144 substrate-Mg2+ binding site; other site 1348662004145 aspartate-rich region 1; other site 1348662004146 aspartate-rich region 2; other site 1348662004147 phytoene desaturase; Region: crtI_fam; TIGR02734 1348662004148 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1348662004149 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1348662004150 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1348662004151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1348662004152 homodimer interface [polypeptide binding]; other site 1348662004153 catalytic residue [active] 1348662004154 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1348662004155 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1348662004156 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1348662004157 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1348662004158 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1348662004159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1348662004160 dimer interface [polypeptide binding]; other site 1348662004161 conserved gate region; other site 1348662004162 putative PBP binding loops; other site 1348662004163 ABC-ATPase subunit interface; other site 1348662004164 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1348662004165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1348662004166 dimer interface [polypeptide binding]; other site 1348662004167 conserved gate region; other site 1348662004168 putative PBP binding loops; other site 1348662004169 ABC-ATPase subunit interface; other site 1348662004170 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1348662004171 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1348662004172 Walker A/P-loop; other site 1348662004173 ATP binding site [chemical binding]; other site 1348662004174 Q-loop/lid; other site 1348662004175 ABC transporter signature motif; other site 1348662004176 Walker B; other site 1348662004177 D-loop; other site 1348662004178 H-loop/switch region; other site 1348662004179 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1348662004180 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1348662004181 Walker A/P-loop; other site 1348662004182 ATP binding site [chemical binding]; other site 1348662004183 Q-loop/lid; other site 1348662004184 ABC transporter signature motif; other site 1348662004185 Walker B; other site 1348662004186 D-loop; other site 1348662004187 H-loop/switch region; other site 1348662004188 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1348662004189 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1348662004190 active site 1348662004191 tetramer interface [polypeptide binding]; other site 1348662004192 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1348662004193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662004194 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1348662004195 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1348662004196 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1348662004197 substrate binding site [chemical binding]; other site 1348662004198 dimer interface [polypeptide binding]; other site 1348662004199 ATP binding site [chemical binding]; other site 1348662004200 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 1348662004201 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1348662004202 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1348662004203 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1348662004204 active site 1348662004205 catalytic tetrad [active] 1348662004206 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1348662004207 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1348662004208 ABC transporter signature motif; other site 1348662004209 Walker B; other site 1348662004210 D-loop; other site 1348662004211 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1348662004212 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1348662004213 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1348662004214 Walker A/P-loop; other site 1348662004215 ATP binding site [chemical binding]; other site 1348662004216 Q-loop/lid; other site 1348662004217 ABC transporter signature motif; other site 1348662004218 Walker B; other site 1348662004219 D-loop; other site 1348662004220 H-loop/switch region; other site 1348662004221 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1348662004222 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1348662004223 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1348662004224 Walker A/P-loop; other site 1348662004225 ATP binding site [chemical binding]; other site 1348662004226 Q-loop/lid; other site 1348662004227 ABC transporter signature motif; other site 1348662004228 Walker B; other site 1348662004229 D-loop; other site 1348662004230 H-loop/switch region; other site 1348662004231 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1348662004232 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1348662004233 active site 1348662004234 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1348662004235 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1348662004236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1348662004237 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1348662004238 NAD(P) binding site [chemical binding]; other site 1348662004239 active site 1348662004240 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1348662004241 Condensation domain; Region: Condensation; pfam00668 1348662004242 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1348662004243 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1348662004244 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1348662004245 Condensation domain; Region: Condensation; pfam00668 1348662004246 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1348662004247 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1348662004248 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1348662004249 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1348662004250 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1348662004251 Condensation domain; Region: Condensation; pfam00668 1348662004252 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1348662004253 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1348662004254 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1348662004255 acyl-activating enzyme (AAE) consensus motif; other site 1348662004256 AMP binding site [chemical binding]; other site 1348662004257 Condensation domain; Region: Condensation; pfam00668 1348662004258 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1348662004259 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1348662004260 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1348662004261 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1348662004262 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1348662004263 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1348662004264 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1348662004265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1348662004266 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 1348662004267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1348662004268 ABC-ATPase subunit interface; other site 1348662004269 putative PBP binding loops; other site 1348662004270 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1348662004271 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1348662004272 Walker A/P-loop; other site 1348662004273 ATP binding site [chemical binding]; other site 1348662004274 Q-loop/lid; other site 1348662004275 ABC transporter signature motif; other site 1348662004276 Walker B; other site 1348662004277 D-loop; other site 1348662004278 H-loop/switch region; other site 1348662004279 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1348662004280 Walker A/P-loop; other site 1348662004281 ATP binding site [chemical binding]; other site 1348662004282 Q-loop/lid; other site 1348662004283 ABC transporter signature motif; other site 1348662004284 Walker B; other site 1348662004285 D-loop; other site 1348662004286 H-loop/switch region; other site 1348662004287 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1348662004288 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1348662004289 GTP-binding protein LepA; Provisional; Region: PRK05433 1348662004290 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1348662004291 G1 box; other site 1348662004292 putative GEF interaction site [polypeptide binding]; other site 1348662004293 GTP/Mg2+ binding site [chemical binding]; other site 1348662004294 Switch I region; other site 1348662004295 G2 box; other site 1348662004296 G3 box; other site 1348662004297 Switch II region; other site 1348662004298 G4 box; other site 1348662004299 G5 box; other site 1348662004300 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1348662004301 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1348662004302 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1348662004303 PemK-like protein; Region: PemK; pfam02452 1348662004304 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1348662004305 hypothetical protein; Validated; Region: PRK05629 1348662004306 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1348662004307 SLBB domain; Region: SLBB; pfam10531 1348662004308 comEA protein; Region: comE; TIGR01259 1348662004309 Helix-hairpin-helix motif; Region: HHH; pfam00633 1348662004310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1348662004311 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1348662004312 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1348662004313 catalytic core [active] 1348662004314 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1348662004315 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1348662004316 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1348662004317 active site 1348662004318 (T/H)XGH motif; other site 1348662004319 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1348662004320 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1348662004321 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1348662004322 Walker A/P-loop; other site 1348662004323 ATP binding site [chemical binding]; other site 1348662004324 Q-loop/lid; other site 1348662004325 ABC transporter signature motif; other site 1348662004326 Walker B; other site 1348662004327 D-loop; other site 1348662004328 H-loop/switch region; other site 1348662004329 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1348662004330 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1348662004331 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1348662004332 putative catalytic cysteine [active] 1348662004333 gamma-glutamyl kinase; Provisional; Region: PRK05429 1348662004334 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1348662004335 nucleotide binding site [chemical binding]; other site 1348662004336 homotetrameric interface [polypeptide binding]; other site 1348662004337 putative phosphate binding site [ion binding]; other site 1348662004338 putative allosteric binding site; other site 1348662004339 PUA domain; Region: PUA; pfam01472 1348662004340 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1348662004341 GTP1/OBG; Region: GTP1_OBG; pfam01018 1348662004342 Obg GTPase; Region: Obg; cd01898 1348662004343 G1 box; other site 1348662004344 GTP/Mg2+ binding site [chemical binding]; other site 1348662004345 Switch I region; other site 1348662004346 G2 box; other site 1348662004347 G3 box; other site 1348662004348 Switch II region; other site 1348662004349 G4 box; other site 1348662004350 G5 box; other site 1348662004351 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1348662004352 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1348662004353 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1348662004354 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1348662004355 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1348662004356 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1348662004357 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1348662004358 homodimer interface [polypeptide binding]; other site 1348662004359 oligonucleotide binding site [chemical binding]; other site 1348662004360 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1348662004361 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1348662004362 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1348662004363 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1348662004364 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1348662004365 Walker A/P-loop; other site 1348662004366 ATP binding site [chemical binding]; other site 1348662004367 Q-loop/lid; other site 1348662004368 ABC transporter signature motif; other site 1348662004369 Walker B; other site 1348662004370 D-loop; other site 1348662004371 H-loop/switch region; other site 1348662004372 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1348662004373 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1348662004374 Walker A/P-loop; other site 1348662004375 ATP binding site [chemical binding]; other site 1348662004376 Q-loop/lid; other site 1348662004377 ABC transporter signature motif; other site 1348662004378 Walker B; other site 1348662004379 D-loop; other site 1348662004380 H-loop/switch region; other site 1348662004381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662004382 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1348662004383 putative substrate translocation pore; other site 1348662004384 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1348662004385 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 1348662004386 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1348662004387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1348662004388 dimer interface [polypeptide binding]; other site 1348662004389 conserved gate region; other site 1348662004390 ABC-ATPase subunit interface; other site 1348662004391 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1348662004392 active site 1348662004393 multimer interface [polypeptide binding]; other site 1348662004394 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1348662004395 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1348662004396 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1348662004397 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1348662004398 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1348662004399 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1348662004400 active site 1348662004401 HIGH motif; other site 1348662004402 nucleotide binding site [chemical binding]; other site 1348662004403 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1348662004404 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1348662004405 active site 1348662004406 KMSKS motif; other site 1348662004407 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1348662004408 tRNA binding surface [nucleotide binding]; other site 1348662004409 anticodon binding site; other site 1348662004410 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1348662004411 malate dehydrogenase; Provisional; Region: PRK05442 1348662004412 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1348662004413 NAD(P) binding site [chemical binding]; other site 1348662004414 dimer interface [polypeptide binding]; other site 1348662004415 malate binding site [chemical binding]; other site 1348662004416 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1348662004417 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1348662004418 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1348662004419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1348662004420 Walker A motif; other site 1348662004421 ATP binding site [chemical binding]; other site 1348662004422 Walker B motif; other site 1348662004423 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1348662004424 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1348662004425 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1348662004426 oligomer interface [polypeptide binding]; other site 1348662004427 active site residues [active] 1348662004428 Clp protease; Region: CLP_protease; pfam00574 1348662004429 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1348662004430 oligomer interface [polypeptide binding]; other site 1348662004431 active site residues [active] 1348662004432 trigger factor; Provisional; Region: tig; PRK01490 1348662004433 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1348662004434 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1348662004435 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1348662004436 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1348662004437 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1348662004438 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1348662004439 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1348662004440 Zn binding site [ion binding]; other site 1348662004441 short chain dehydrogenase; Provisional; Region: PRK08219 1348662004442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1348662004443 NAD(P) binding site [chemical binding]; other site 1348662004444 active site 1348662004445 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1348662004446 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1348662004447 Walker A/P-loop; other site 1348662004448 ATP binding site [chemical binding]; other site 1348662004449 Q-loop/lid; other site 1348662004450 ABC transporter signature motif; other site 1348662004451 Walker B; other site 1348662004452 D-loop; other site 1348662004453 H-loop/switch region; other site 1348662004454 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1348662004455 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1348662004456 Walker A/P-loop; other site 1348662004457 ATP binding site [chemical binding]; other site 1348662004458 Q-loop/lid; other site 1348662004459 ABC transporter signature motif; other site 1348662004460 Walker B; other site 1348662004461 D-loop; other site 1348662004462 H-loop/switch region; other site 1348662004463 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1348662004464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1348662004465 putative PBP binding loops; other site 1348662004466 dimer interface [polypeptide binding]; other site 1348662004467 ABC-ATPase subunit interface; other site 1348662004468 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1348662004469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1348662004470 dimer interface [polypeptide binding]; other site 1348662004471 conserved gate region; other site 1348662004472 putative PBP binding loops; other site 1348662004473 ABC-ATPase subunit interface; other site 1348662004474 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1348662004475 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1348662004476 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1348662004477 cystathionine gamma-synthase; Provisional; Region: PRK07811 1348662004478 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1348662004479 homodimer interface [polypeptide binding]; other site 1348662004480 substrate-cofactor binding pocket; other site 1348662004481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1348662004482 catalytic residue [active] 1348662004483 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1348662004484 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1348662004485 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1348662004486 apolar tunnel; other site 1348662004487 heme binding site [chemical binding]; other site 1348662004488 dimerization interface [polypeptide binding]; other site 1348662004489 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1348662004490 active site 1348662004491 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1348662004492 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1348662004493 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1348662004494 dimerization interface [polypeptide binding]; other site 1348662004495 putative DNA binding site [nucleotide binding]; other site 1348662004496 putative Zn2+ binding site [ion binding]; other site 1348662004497 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 1348662004498 Cadmium resistance transporter; Region: Cad; pfam03596 1348662004499 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1348662004500 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1348662004501 dimer interface [polypeptide binding]; other site 1348662004502 ssDNA binding site [nucleotide binding]; other site 1348662004503 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1348662004504 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1348662004505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1348662004506 Walker A/P-loop; other site 1348662004507 ATP binding site [chemical binding]; other site 1348662004508 Q-loop/lid; other site 1348662004509 ABC transporter signature motif; other site 1348662004510 Walker B; other site 1348662004511 D-loop; other site 1348662004512 H-loop/switch region; other site 1348662004513 ABC transporter; Region: ABC_tran_2; pfam12848 1348662004514 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1348662004515 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 1348662004516 putative catalytic site [active] 1348662004517 putative metal binding site [ion binding]; other site 1348662004518 putative phosphate binding site [ion binding]; other site 1348662004519 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1348662004520 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1348662004521 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1348662004522 active site residue [active] 1348662004523 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1348662004524 active site residue [active] 1348662004525 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1348662004526 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1348662004527 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1348662004528 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1348662004529 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1348662004530 carboxyltransferase (CT) interaction site; other site 1348662004531 biotinylation site [posttranslational modification]; other site 1348662004532 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1348662004533 pyruvate carboxylase; Reviewed; Region: PRK12999 1348662004534 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1348662004535 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1348662004536 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1348662004537 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1348662004538 active site 1348662004539 catalytic residues [active] 1348662004540 metal binding site [ion binding]; metal-binding site 1348662004541 homodimer binding site [polypeptide binding]; other site 1348662004542 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1348662004543 carboxyltransferase (CT) interaction site; other site 1348662004544 biotinylation site [posttranslational modification]; other site 1348662004545 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1348662004546 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1348662004547 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1348662004548 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1348662004549 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1348662004550 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1348662004551 metal binding site [ion binding]; metal-binding site 1348662004552 putative dimer interface [polypeptide binding]; other site 1348662004553 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1348662004554 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1348662004555 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1348662004556 active site 1348662004557 substrate binding site [chemical binding]; other site 1348662004558 metal binding site [ion binding]; metal-binding site 1348662004559 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1348662004560 active site 1348662004561 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1348662004562 NlpC/P60 family; Region: NLPC_P60; pfam00877 1348662004563 adenosine deaminase; Provisional; Region: PRK09358 1348662004564 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1348662004565 active site 1348662004566 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1348662004567 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1348662004568 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1348662004569 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1348662004570 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1348662004571 active site 1348662004572 HIGH motif; other site 1348662004573 dimer interface [polypeptide binding]; other site 1348662004574 KMSKS motif; other site 1348662004575 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1348662004576 putative catalytic site [active] 1348662004577 putative metal binding site [ion binding]; other site 1348662004578 putative phosphate binding site [ion binding]; other site 1348662004579 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1348662004580 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1348662004581 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1348662004582 Htaa; Region: HtaA; pfam04213 1348662004583 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 1348662004584 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1348662004585 homodimer interface [polypeptide binding]; other site 1348662004586 substrate-cofactor binding pocket; other site 1348662004587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1348662004588 catalytic residue [active] 1348662004589 Htaa; Region: HtaA; pfam04213 1348662004590 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1348662004591 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1348662004592 Walker A/P-loop; other site 1348662004593 ATP binding site [chemical binding]; other site 1348662004594 Q-loop/lid; other site 1348662004595 ABC transporter signature motif; other site 1348662004596 Walker B; other site 1348662004597 D-loop; other site 1348662004598 H-loop/switch region; other site 1348662004599 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1348662004600 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1348662004601 ABC-ATPase subunit interface; other site 1348662004602 dimer interface [polypeptide binding]; other site 1348662004603 putative PBP binding regions; other site 1348662004604 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1348662004605 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1348662004606 intersubunit interface [polypeptide binding]; other site 1348662004607 Htaa; Region: HtaA; pfam04213 1348662004608 Htaa; Region: HtaA; pfam04213 1348662004609 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1348662004610 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1348662004611 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1348662004612 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1348662004613 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1348662004614 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1348662004615 homodimer interface [polypeptide binding]; other site 1348662004616 NADP binding site [chemical binding]; other site 1348662004617 substrate binding site [chemical binding]; other site 1348662004618 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1348662004619 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1348662004620 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1348662004621 FeoA domain; Region: FeoA; pfam04023 1348662004622 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1348662004623 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1348662004624 ABC-ATPase subunit interface; other site 1348662004625 dimer interface [polypeptide binding]; other site 1348662004626 putative PBP binding regions; other site 1348662004627 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1348662004628 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1348662004629 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1348662004630 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1348662004631 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1348662004632 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1348662004633 intersubunit interface [polypeptide binding]; other site 1348662004634 Predicted membrane protein [Function unknown]; Region: COG3428 1348662004635 Bacterial PH domain; Region: DUF304; pfam03703 1348662004636 Bacterial PH domain; Region: DUF304; pfam03703 1348662004637 Bacterial PH domain; Region: DUF304; pfam03703 1348662004638 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1348662004639 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1348662004640 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1348662004641 active site 1348662004642 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1348662004643 generic binding surface I; other site 1348662004644 generic binding surface II; other site 1348662004645 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1348662004646 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1348662004647 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1348662004648 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1348662004649 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1348662004650 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1348662004651 Walker A/P-loop; other site 1348662004652 ATP binding site [chemical binding]; other site 1348662004653 Q-loop/lid; other site 1348662004654 ABC transporter signature motif; other site 1348662004655 Walker B; other site 1348662004656 D-loop; other site 1348662004657 H-loop/switch region; other site 1348662004658 NIL domain; Region: NIL; cl09633 1348662004659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1348662004660 dimer interface [polypeptide binding]; other site 1348662004661 conserved gate region; other site 1348662004662 ABC-ATPase subunit interface; other site 1348662004663 Recombination, repair and ssDNA binding protein UvsY; Region: UvsY; pfam11056 1348662004664 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 1348662004665 putative dimer interface [polypeptide binding]; other site 1348662004666 putative [2Fe-2S] cluster binding site [ion binding]; other site 1348662004667 DNA Polymerase Y-family; Region: PolY_like; cd03468 1348662004668 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1348662004669 DNA binding site [nucleotide binding] 1348662004670 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1348662004671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1348662004672 active site 1348662004673 phosphorylation site [posttranslational modification] 1348662004674 intermolecular recognition site; other site 1348662004675 dimerization interface [polypeptide binding]; other site 1348662004676 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1348662004677 DNA binding residues [nucleotide binding] 1348662004678 dimerization interface [polypeptide binding]; other site 1348662004679 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1348662004680 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1348662004681 ATP binding site [chemical binding]; other site 1348662004682 G-X-G motif; other site 1348662004683 GMP synthase; Reviewed; Region: guaA; PRK00074 1348662004684 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1348662004685 AMP/PPi binding site [chemical binding]; other site 1348662004686 candidate oxyanion hole; other site 1348662004687 catalytic triad [active] 1348662004688 potential glutamine specificity residues [chemical binding]; other site 1348662004689 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1348662004690 ATP Binding subdomain [chemical binding]; other site 1348662004691 Ligand Binding sites [chemical binding]; other site 1348662004692 Dimerization subdomain; other site 1348662004693 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1348662004694 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1348662004695 phosphate binding site [ion binding]; other site 1348662004696 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1348662004697 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1348662004698 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1348662004699 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1348662004700 active site 1348662004701 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1348662004702 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1348662004703 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1348662004704 DNA binding residues [nucleotide binding] 1348662004705 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1348662004706 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1348662004707 ring oligomerisation interface [polypeptide binding]; other site 1348662004708 ATP/Mg binding site [chemical binding]; other site 1348662004709 stacking interactions; other site 1348662004710 hinge regions; other site 1348662004711 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1348662004712 oligomerisation interface [polypeptide binding]; other site 1348662004713 mobile loop; other site 1348662004714 roof hairpin; other site 1348662004715 UGMP family protein; Validated; Region: PRK09604 1348662004716 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1348662004717 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1348662004718 Coenzyme A binding pocket [chemical binding]; other site 1348662004719 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1348662004720 Glycoprotease family; Region: Peptidase_M22; pfam00814 1348662004721 alanine racemase; Reviewed; Region: alr; PRK00053 1348662004722 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1348662004723 active site 1348662004724 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1348662004725 dimer interface [polypeptide binding]; other site 1348662004726 substrate binding site [chemical binding]; other site 1348662004727 catalytic residues [active] 1348662004728 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1348662004729 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1348662004730 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1348662004731 putative substrate binding site [chemical binding]; other site 1348662004732 putative ATP binding site [chemical binding]; other site 1348662004733 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1348662004734 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1348662004735 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1348662004736 glutaminase active site [active] 1348662004737 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1348662004738 dimer interface [polypeptide binding]; other site 1348662004739 active site 1348662004740 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1348662004741 dimer interface [polypeptide binding]; other site 1348662004742 active site 1348662004743 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1348662004744 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1348662004745 active site 1348662004746 substrate binding site [chemical binding]; other site 1348662004747 metal binding site [ion binding]; metal-binding site 1348662004748 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1348662004749 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1348662004750 catalytic triad [active] 1348662004751 catalytic triad [active] 1348662004752 oxyanion hole [active] 1348662004753 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1348662004754 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1348662004755 23S rRNA interface [nucleotide binding]; other site 1348662004756 L3 interface [polypeptide binding]; other site 1348662004757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1348662004758 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1348662004759 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1348662004760 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1348662004761 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1348662004762 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1348662004763 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1348662004764 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1348662004765 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1348662004766 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1348662004767 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1348662004768 active site 1348662004769 catalytic residues [active] 1348662004770 YwiC-like protein; Region: YwiC; pfam14256 1348662004771 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1348662004772 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1348662004773 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1348662004774 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1348662004775 motif II; other site 1348662004776 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1348662004777 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1348662004778 D-pathway; other site 1348662004779 Putative ubiquinol binding site [chemical binding]; other site 1348662004780 Low-spin heme (heme b) binding site [chemical binding]; other site 1348662004781 Putative water exit pathway; other site 1348662004782 Binuclear center (heme o3/CuB) [ion binding]; other site 1348662004783 K-pathway; other site 1348662004784 Putative proton exit pathway; other site 1348662004785 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1348662004786 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1348662004787 dimer interface [polypeptide binding]; other site 1348662004788 putative radical transfer pathway; other site 1348662004789 diiron center [ion binding]; other site 1348662004790 tyrosyl radical; other site 1348662004791 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1348662004792 Ferritin-like domain; Region: Ferritin; pfam00210 1348662004793 ferroxidase diiron center [ion binding]; other site 1348662004794 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1348662004795 ATP-binding site [chemical binding]; other site 1348662004796 Gluconate-6-phosphate binding site [chemical binding]; other site 1348662004797 Shikimate kinase; Region: SKI; pfam01202 1348662004798 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1348662004799 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1348662004800 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1348662004801 active site 1348662004802 dimer interface [polypeptide binding]; other site 1348662004803 catalytic residues [active] 1348662004804 effector binding site; other site 1348662004805 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1348662004806 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1348662004807 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1348662004808 catalytic residues [active] 1348662004809 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1348662004810 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1348662004811 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1348662004812 homodimer interface [polypeptide binding]; other site 1348662004813 NAD binding pocket [chemical binding]; other site 1348662004814 ATP binding pocket [chemical binding]; other site 1348662004815 Mg binding site [ion binding]; other site 1348662004816 active-site loop [active] 1348662004817 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1348662004818 Thioredoxin; Region: Thioredoxin_4; cl17273 1348662004819 phosphoglucomutase; Validated; Region: PRK07564 1348662004820 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1348662004821 active site 1348662004822 substrate binding site [chemical binding]; other site 1348662004823 metal binding site [ion binding]; metal-binding site 1348662004824 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1348662004825 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1348662004826 CrcB-like protein; Region: CRCB; cl09114 1348662004827 CrcB-like protein; Region: CRCB; pfam02537 1348662004828 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1348662004829 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1348662004830 hinge; other site 1348662004831 active site 1348662004832 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1348662004833 GAF domain; Region: GAF; cl17456 1348662004834 GAF domain; Region: GAF_2; pfam13185 1348662004835 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1348662004836 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1348662004837 DNA binding residues [nucleotide binding] 1348662004838 dimerization interface [polypeptide binding]; other site 1348662004839 serine O-acetyltransferase; Region: cysE; TIGR01172 1348662004840 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1348662004841 trimer interface [polypeptide binding]; other site 1348662004842 active site 1348662004843 substrate binding site [chemical binding]; other site 1348662004844 CoA binding site [chemical binding]; other site 1348662004845 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1348662004846 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1348662004847 dimer interface [polypeptide binding]; other site 1348662004848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1348662004849 catalytic residue [active] 1348662004850 cobalt transport protein CbiM; Validated; Region: PRK08319 1348662004851 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1348662004852 cobalt transport protein CbiN; Provisional; Region: PRK02898 1348662004853 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1348662004854 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1348662004855 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1348662004856 Walker A/P-loop; other site 1348662004857 ATP binding site [chemical binding]; other site 1348662004858 Q-loop/lid; other site 1348662004859 ABC transporter signature motif; other site 1348662004860 Walker B; other site 1348662004861 D-loop; other site 1348662004862 H-loop/switch region; other site 1348662004863 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1348662004864 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1348662004865 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1348662004866 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1348662004867 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1348662004868 FMN binding site [chemical binding]; other site 1348662004869 active site 1348662004870 catalytic residues [active] 1348662004871 substrate binding site [chemical binding]; other site 1348662004872 putative acyltransferase; Provisional; Region: PRK05790 1348662004873 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1348662004874 dimer interface [polypeptide binding]; other site 1348662004875 active site 1348662004876 enoyl-CoA hydratase; Provisional; Region: PRK05862 1348662004877 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1348662004878 substrate binding site [chemical binding]; other site 1348662004879 oxyanion hole (OAH) forming residues; other site 1348662004880 trimer interface [polypeptide binding]; other site 1348662004881 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1348662004882 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1348662004883 acyl-activating enzyme (AAE) consensus motif; other site 1348662004884 AMP binding site [chemical binding]; other site 1348662004885 active site 1348662004886 CoA binding site [chemical binding]; other site 1348662004887 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1348662004888 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1348662004889 active site 1348662004890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1348662004891 NAD(P) binding site [chemical binding]; other site 1348662004892 active site 1348662004893 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1348662004894 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1348662004895 active site 1348662004896 Zn binding site [ion binding]; other site 1348662004897 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1348662004898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1348662004899 Coenzyme A binding pocket [chemical binding]; other site 1348662004900 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1348662004901 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1348662004902 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1348662004903 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1348662004904 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1348662004905 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1348662004906 heme-binding site [chemical binding]; other site 1348662004907 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1348662004908 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1348662004909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1348662004910 catalytic residue [active] 1348662004911 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1348662004912 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1348662004913 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1348662004914 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1348662004915 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1348662004916 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1348662004917 dimerization interface [polypeptide binding]; other site 1348662004918 putative ATP binding site [chemical binding]; other site 1348662004919 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1348662004920 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1348662004921 active site 1348662004922 tetramer interface [polypeptide binding]; other site 1348662004923 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1348662004924 active site 1348662004925 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1348662004926 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1348662004927 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1348662004928 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1348662004929 dimerization interface [polypeptide binding]; other site 1348662004930 ATP binding site [chemical binding]; other site 1348662004931 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1348662004932 dimerization interface [polypeptide binding]; other site 1348662004933 ATP binding site [chemical binding]; other site 1348662004934 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1348662004935 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1348662004936 putative active site [active] 1348662004937 catalytic triad [active] 1348662004938 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1348662004939 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1348662004940 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1348662004941 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1348662004942 ATP binding site [chemical binding]; other site 1348662004943 active site 1348662004944 substrate binding site [chemical binding]; other site 1348662004945 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1348662004946 Predicted esterase [General function prediction only]; Region: COG0627 1348662004947 adenylosuccinate lyase; Region: purB; TIGR00928 1348662004948 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1348662004949 tetramer interface [polypeptide binding]; other site 1348662004950 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1348662004951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1348662004952 homodimer interface [polypeptide binding]; other site 1348662004953 catalytic residue [active] 1348662004954 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1348662004955 TrkA-N domain; Region: TrkA_N; pfam02254 1348662004956 TrkA-C domain; Region: TrkA_C; pfam02080 1348662004957 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1348662004958 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1348662004959 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1348662004960 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1348662004961 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1348662004962 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1348662004963 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1348662004964 nucleotide binding site/active site [active] 1348662004965 HIT family signature motif; other site 1348662004966 catalytic residue [active] 1348662004967 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1348662004968 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1348662004969 catalytic site [active] 1348662004970 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1348662004971 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1348662004972 catalytic loop [active] 1348662004973 iron binding site [ion binding]; other site 1348662004974 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1348662004975 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1348662004976 dimerization interface [polypeptide binding]; other site 1348662004977 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1348662004978 dimer interface [polypeptide binding]; other site 1348662004979 phosphorylation site [posttranslational modification] 1348662004980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1348662004981 ATP binding site [chemical binding]; other site 1348662004982 Mg2+ binding site [ion binding]; other site 1348662004983 G-X-G motif; other site 1348662004984 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1348662004985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1348662004986 active site 1348662004987 phosphorylation site [posttranslational modification] 1348662004988 intermolecular recognition site; other site 1348662004989 dimerization interface [polypeptide binding]; other site 1348662004990 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1348662004991 DNA binding site [nucleotide binding] 1348662004992 pyruvate dehydrogenase; Provisional; Region: PRK06546 1348662004993 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1348662004994 PYR/PP interface [polypeptide binding]; other site 1348662004995 dimer interface [polypeptide binding]; other site 1348662004996 tetramer interface [polypeptide binding]; other site 1348662004997 TPP binding site [chemical binding]; other site 1348662004998 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1348662004999 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1348662005000 TPP-binding site [chemical binding]; other site 1348662005001 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1348662005002 Isochorismatase family; Region: Isochorismatase; pfam00857 1348662005003 catalytic triad [active] 1348662005004 metal binding site [ion binding]; metal-binding site 1348662005005 conserved cis-peptide bond; other site 1348662005006 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1348662005007 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1348662005008 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1348662005009 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1348662005010 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1348662005011 active site 1348662005012 homotetramer interface [polypeptide binding]; other site 1348662005013 META domain; Region: META; cl01245 1348662005014 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1348662005015 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1348662005016 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1348662005017 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1348662005018 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1348662005019 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1348662005020 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1348662005021 active site 1348662005022 HIGH motif; other site 1348662005023 nucleotide binding site [chemical binding]; other site 1348662005024 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1348662005025 KMSKS motif; other site 1348662005026 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1348662005027 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1348662005028 homotrimer interaction site [polypeptide binding]; other site 1348662005029 zinc binding site [ion binding]; other site 1348662005030 CDP-binding sites; other site 1348662005031 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1348662005032 substrate binding site; other site 1348662005033 dimer interface; other site 1348662005034 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1348662005035 Domain of unknown function DUF11; Region: DUF11; pfam01345 1348662005036 Domain of unknown function DUF11; Region: DUF11; pfam01345 1348662005037 DNA repair protein RadA; Provisional; Region: PRK11823 1348662005038 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1348662005039 Walker A motif; other site 1348662005040 ATP binding site [chemical binding]; other site 1348662005041 Walker B motif; other site 1348662005042 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1348662005043 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1348662005044 active site clefts [active] 1348662005045 zinc binding site [ion binding]; other site 1348662005046 dimer interface [polypeptide binding]; other site 1348662005047 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1348662005048 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1348662005049 minor groove reading motif; other site 1348662005050 helix-hairpin-helix signature motif; other site 1348662005051 active site 1348662005052 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1348662005053 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 1348662005054 Clp protease ATP binding subunit; Region: clpC; CHL00095 1348662005055 Clp amino terminal domain; Region: Clp_N; pfam02861 1348662005056 Clp amino terminal domain; Region: Clp_N; pfam02861 1348662005057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1348662005058 Walker A motif; other site 1348662005059 ATP binding site [chemical binding]; other site 1348662005060 Walker B motif; other site 1348662005061 arginine finger; other site 1348662005062 UvrB/uvrC motif; Region: UVR; pfam02151 1348662005063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1348662005064 Walker A motif; other site 1348662005065 ATP binding site [chemical binding]; other site 1348662005066 Walker B motif; other site 1348662005067 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1348662005068 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1348662005069 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1348662005070 dimer interface [polypeptide binding]; other site 1348662005071 putative anticodon binding site; other site 1348662005072 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1348662005073 motif 1; other site 1348662005074 dimer interface [polypeptide binding]; other site 1348662005075 active site 1348662005076 motif 2; other site 1348662005077 motif 3; other site 1348662005078 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1348662005079 active site 1348662005080 HIGH motif; other site 1348662005081 nucleotide binding site [chemical binding]; other site 1348662005082 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1348662005083 catalytic center binding site [active] 1348662005084 ATP binding site [chemical binding]; other site 1348662005085 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1348662005086 homooctamer interface [polypeptide binding]; other site 1348662005087 active site 1348662005088 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1348662005089 dihydropteroate synthase; Region: DHPS; TIGR01496 1348662005090 substrate binding pocket [chemical binding]; other site 1348662005091 dimer interface [polypeptide binding]; other site 1348662005092 inhibitor binding site; inhibition site 1348662005093 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1348662005094 homodecamer interface [polypeptide binding]; other site 1348662005095 GTP cyclohydrolase I; Provisional; Region: PLN03044 1348662005096 active site 1348662005097 putative catalytic site residues [active] 1348662005098 zinc binding site [ion binding]; other site 1348662005099 GTP-CH-I/GFRP interaction surface; other site 1348662005100 FtsH Extracellular; Region: FtsH_ext; pfam06480 1348662005101 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1348662005102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1348662005103 Walker A motif; other site 1348662005104 ATP binding site [chemical binding]; other site 1348662005105 Walker B motif; other site 1348662005106 arginine finger; other site 1348662005107 Peptidase family M41; Region: Peptidase_M41; pfam01434 1348662005108 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1348662005109 active site 1348662005110 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1348662005111 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1348662005112 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1348662005113 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1348662005114 dimer interface [polypeptide binding]; other site 1348662005115 substrate binding site [chemical binding]; other site 1348662005116 metal binding sites [ion binding]; metal-binding site 1348662005117 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1348662005118 MarR family; Region: MarR_2; pfam12802 1348662005119 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1348662005120 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1348662005121 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1348662005122 ring oligomerisation interface [polypeptide binding]; other site 1348662005123 ATP/Mg binding site [chemical binding]; other site 1348662005124 stacking interactions; other site 1348662005125 hinge regions; other site 1348662005126 hypothetical protein; Provisional; Region: PRK07907 1348662005127 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1348662005128 active site 1348662005129 metal binding site [ion binding]; metal-binding site 1348662005130 dimer interface [polypeptide binding]; other site 1348662005131 2-isopropylmalate synthase; Validated; Region: PRK03739 1348662005132 carboxylate-amine ligase; Provisional; Region: PRK13517 1348662005133 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1348662005134 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1348662005135 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1348662005136 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1348662005137 active site 1348662005138 catalytic residues [active] 1348662005139 metal binding site [ion binding]; metal-binding site 1348662005140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1348662005141 Coenzyme A binding pocket [chemical binding]; other site 1348662005142 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1348662005143 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1348662005144 putative catalytic site [active] 1348662005145 putative metal binding site [ion binding]; other site 1348662005146 putative phosphate binding site [ion binding]; other site 1348662005147 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1348662005148 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1348662005149 putative active site [active] 1348662005150 catalytic site [active] 1348662005151 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1348662005152 putative active site [active] 1348662005153 catalytic site [active] 1348662005154 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1348662005155 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1348662005156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1348662005157 Walker A/P-loop; other site 1348662005158 ATP binding site [chemical binding]; other site 1348662005159 Q-loop/lid; other site 1348662005160 ABC transporter signature motif; other site 1348662005161 Walker B; other site 1348662005162 D-loop; other site 1348662005163 H-loop/switch region; other site 1348662005164 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1348662005165 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1348662005166 active site 1348662005167 ATP binding site [chemical binding]; other site 1348662005168 substrate binding site [chemical binding]; other site 1348662005169 activation loop (A-loop); other site 1348662005170 propionate/acetate kinase; Provisional; Region: PRK12379 1348662005171 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1348662005172 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1348662005173 ferredoxin-NADP+ reductase; Region: PLN02852 1348662005174 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1348662005175 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1348662005176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1348662005177 ATP-grasp domain; Region: ATP-grasp; pfam02222 1348662005178 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1348662005179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1348662005180 active site 1348662005181 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1348662005182 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1348662005183 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1348662005184 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1348662005185 GDP-binding site [chemical binding]; other site 1348662005186 ACT binding site; other site 1348662005187 IMP binding site; other site 1348662005188 Predicted membrane protein [Function unknown]; Region: COG4129 1348662005189 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1348662005190 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1348662005191 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1348662005192 active site 1348662005193 intersubunit interface [polypeptide binding]; other site 1348662005194 zinc binding site [ion binding]; other site 1348662005195 Na+ binding site [ion binding]; other site 1348662005196 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1348662005197 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1348662005198 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1348662005199 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1348662005200 active site 1348662005201 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1348662005202 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1348662005203 active site residue [active] 1348662005204 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1348662005205 active site residue [active] 1348662005206 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1348662005207 Clp amino terminal domain; Region: Clp_N; pfam02861 1348662005208 Clp amino terminal domain; Region: Clp_N; pfam02861 1348662005209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1348662005210 Walker A motif; other site 1348662005211 ATP binding site [chemical binding]; other site 1348662005212 Walker B motif; other site 1348662005213 arginine finger; other site 1348662005214 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1348662005215 Walker A motif; other site 1348662005216 ATP binding site [chemical binding]; other site 1348662005217 Walker B motif; other site 1348662005218 arginine finger; other site 1348662005219 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1348662005220 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1348662005221 FAD binding pocket [chemical binding]; other site 1348662005222 conserved FAD binding motif [chemical binding]; other site 1348662005223 beta-alpha-beta structure motif; other site 1348662005224 NAD binding pocket [chemical binding]; other site 1348662005225 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1348662005226 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1348662005227 putative active site [active] 1348662005228 catalytic triad [active] 1348662005229 putative dimer interface [polypeptide binding]; other site 1348662005230 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1348662005231 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1348662005232 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1348662005233 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1348662005234 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1348662005235 DNA binding residues [nucleotide binding] 1348662005236 putative dimer interface [polypeptide binding]; other site 1348662005237 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1348662005238 HSP70 interaction site [polypeptide binding]; other site 1348662005239 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 1348662005240 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1348662005241 Zn binding sites [ion binding]; other site 1348662005242 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1348662005243 dimer interface [polypeptide binding]; other site 1348662005244 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1348662005245 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1348662005246 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1348662005247 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1348662005248 nucleotide binding site [chemical binding]; other site 1348662005249 NEF interaction site [polypeptide binding]; other site 1348662005250 SBD interface [polypeptide binding]; other site 1348662005251 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1348662005252 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1348662005253 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1348662005254 4Fe-4S binding domain; Region: Fer4; cl02805 1348662005255 Cysteine-rich domain; Region: CCG; pfam02754 1348662005256 Cysteine-rich domain; Region: CCG; pfam02754 1348662005257 aminotransferase AlaT; Validated; Region: PRK09265 1348662005258 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1348662005259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1348662005260 homodimer interface [polypeptide binding]; other site 1348662005261 catalytic residue [active] 1348662005262 YibE/F-like protein; Region: YibE_F; pfam07907 1348662005263 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1348662005264 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1348662005265 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1348662005266 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1348662005267 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1348662005268 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1348662005269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1348662005270 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1348662005271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1348662005272 Walker A/P-loop; other site 1348662005273 ATP binding site [chemical binding]; other site 1348662005274 Q-loop/lid; other site 1348662005275 ABC transporter signature motif; other site 1348662005276 Walker B; other site 1348662005277 D-loop; other site 1348662005278 H-loop/switch region; other site 1348662005279 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1348662005280 trimer interface [polypeptide binding]; other site 1348662005281 active site 1348662005282 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1348662005283 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1348662005284 Yqey-like protein; Region: YqeY; pfam09424 1348662005285 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1348662005286 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1348662005287 Predicted membrane protein [Function unknown]; Region: COG1511 1348662005288 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1348662005289 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1348662005290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1348662005291 Walker A/P-loop; other site 1348662005292 ATP binding site [chemical binding]; other site 1348662005293 Q-loop/lid; other site 1348662005294 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1348662005295 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 1348662005296 gating phenylalanine in ion channel; other site 1348662005297 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1348662005298 VanW like protein; Region: VanW; pfam04294 1348662005299 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1348662005300 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1348662005301 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1348662005302 Ligand Binding Site [chemical binding]; other site 1348662005303 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1348662005304 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1348662005305 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1348662005306 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1348662005307 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1348662005308 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1348662005309 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1348662005310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1348662005311 S-adenosylmethionine binding site [chemical binding]; other site 1348662005312 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1348662005313 active site 1348662005314 substrate-binding site [chemical binding]; other site 1348662005315 metal-binding site [ion binding] 1348662005316 GTP binding site [chemical binding]; other site 1348662005317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1348662005318 S-adenosylmethionine binding site [chemical binding]; other site 1348662005319 LabA_like proteins; Region: LabA_like; cd06167 1348662005320 putative metal binding site [ion binding]; other site 1348662005321 MMPL family; Region: MMPL; pfam03176 1348662005322 MMPL family; Region: MMPL; pfam03176 1348662005323 Predicted integral membrane protein [Function unknown]; Region: COG0392 1348662005324 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1348662005325 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1348662005326 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1348662005327 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1348662005328 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1348662005329 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1348662005330 active site 1348662005331 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1348662005332 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1348662005333 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1348662005334 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1348662005335 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1348662005336 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1348662005337 acyl-activating enzyme (AAE) consensus motif; other site 1348662005338 active site 1348662005339 Cutinase; Region: Cutinase; pfam01083 1348662005340 Putative esterase; Region: Esterase; pfam00756 1348662005341 S-formylglutathione hydrolase; Region: PLN02442 1348662005342 LGFP repeat; Region: LGFP; pfam08310 1348662005343 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1348662005344 LGFP repeat; Region: LGFP; pfam08310 1348662005345 LGFP repeat; Region: LGFP; pfam08310 1348662005346 Putative esterase; Region: Esterase; pfam00756 1348662005347 S-formylglutathione hydrolase; Region: PLN02442 1348662005348 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1348662005349 UbiA prenyltransferase family; Region: UbiA; pfam01040 1348662005350 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1348662005351 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1348662005352 active site 1348662005353 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1348662005354 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1348662005355 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 1348662005356 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1348662005357 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1348662005358 UDP-galactopyranose mutase; Region: GLF; pfam03275 1348662005359 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1348662005360 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1348662005361 amidase catalytic site [active] 1348662005362 Zn binding residues [ion binding]; other site 1348662005363 substrate binding site [chemical binding]; other site 1348662005364 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1348662005365 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1348662005366 active site 1348662005367 motif I; other site 1348662005368 motif II; other site 1348662005369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1348662005370 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1348662005371 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1348662005372 putative acyl-acceptor binding pocket; other site 1348662005373 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1348662005374 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1348662005375 active site 1348662005376 motif I; other site 1348662005377 motif II; other site 1348662005378 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1348662005379 seryl-tRNA synthetase; Provisional; Region: PRK05431 1348662005380 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1348662005381 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1348662005382 dimer interface [polypeptide binding]; other site 1348662005383 active site 1348662005384 motif 1; other site 1348662005385 motif 2; other site 1348662005386 motif 3; other site 1348662005387 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1348662005388 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1348662005389 DNA-binding site [nucleotide binding]; DNA binding site 1348662005390 UTRA domain; Region: UTRA; pfam07702 1348662005391 Septum formation; Region: Septum_form; pfam13845 1348662005392 Septum formation; Region: Septum_form; pfam13845 1348662005393 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1348662005394 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1348662005395 catalytic core [active] 1348662005396 prephenate dehydratase; Provisional; Region: PRK11898 1348662005397 Prephenate dehydratase; Region: PDT; pfam00800 1348662005398 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1348662005399 putative L-Phe binding site [chemical binding]; other site 1348662005400 Amidase; Region: Amidase; cl11426 1348662005401 CAAX protease self-immunity; Region: Abi; pfam02517 1348662005402 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1348662005403 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1348662005404 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1348662005405 NAD binding site [chemical binding]; other site 1348662005406 dimer interface [polypeptide binding]; other site 1348662005407 substrate binding site [chemical binding]; other site 1348662005408 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1348662005409 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1348662005410 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1348662005411 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1348662005412 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1348662005413 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1348662005414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1348662005415 putative substrate translocation pore; other site 1348662005416 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1348662005417 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1348662005418 Lsr2; Region: Lsr2; pfam11774 1348662005419 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1348662005420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1348662005421 active site 1348662005422 phosphorylation site [posttranslational modification] 1348662005423 intermolecular recognition site; other site 1348662005424 dimerization interface [polypeptide binding]; other site 1348662005425 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1348662005426 DNA binding residues [nucleotide binding] 1348662005427 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1348662005428 Histidine kinase; Region: HisKA_3; pfam07730 1348662005429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1348662005430 ATP binding site [chemical binding]; other site 1348662005431 Mg2+ binding site [ion binding]; other site 1348662005432 G-X-G motif; other site 1348662005433 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 1348662005434 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1348662005435 active site 1348662005436 catalytic site [active] 1348662005437 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1348662005438 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1348662005439 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1348662005440 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1348662005441 Ligand Binding Site [chemical binding]; other site 1348662005442 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1348662005443 Ligand Binding Site [chemical binding]; other site 1348662005444 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1348662005445 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1348662005446 active site 1348662005447 LabA_like proteins; Region: LabA_like; cd06167 1348662005448 putative metal binding site [ion binding]; other site 1348662005449 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1348662005450 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1348662005451 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1348662005452 catalytic residues [active] 1348662005453 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1348662005454 metal-binding site [ion binding] 1348662005455 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1348662005456 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1348662005457 metal-binding site [ion binding] 1348662005458 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1348662005459 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1348662005460 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1348662005461 Abi-like protein; Region: Abi_2; cl01988 1348662005462 replicative DNA helicase; Provisional; Region: PRK05636 1348662005463 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1348662005464 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1348662005465 Walker A motif; other site 1348662005466 ATP binding site [chemical binding]; other site 1348662005467 Walker B motif; other site 1348662005468 DNA binding loops [nucleotide binding] 1348662005469 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1348662005470 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1348662005471 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1348662005472 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1348662005473 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1348662005474 dimer interface [polypeptide binding]; other site 1348662005475 ssDNA binding site [nucleotide binding]; other site 1348662005476 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1348662005477 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1348662005478 Transglycosylase; Region: Transgly; pfam00912 1348662005479 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1348662005480 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1348662005481 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1348662005482 MarR family; Region: MarR; pfam01047 1348662005483 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1348662005484 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1348662005485 active site residue [active] 1348662005486 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1348662005487 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1348662005488 non-specific DNA binding site [nucleotide binding]; other site 1348662005489 salt bridge; other site 1348662005490 sequence-specific DNA binding site [nucleotide binding]; other site 1348662005491 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1348662005492 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1348662005493 putative DNA binding site [nucleotide binding]; other site 1348662005494 catalytic residue [active] 1348662005495 putative H2TH interface [polypeptide binding]; other site 1348662005496 putative catalytic residues [active] 1348662005497 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1348662005498 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1348662005499 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1348662005500 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1348662005501 active site 1348662005502 HIGH motif; other site 1348662005503 nucleotide binding site [chemical binding]; other site 1348662005504 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1348662005505 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1348662005506 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1348662005507 active site 1348662005508 KMSKS motif; other site 1348662005509 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1348662005510 tRNA binding surface [nucleotide binding]; other site 1348662005511 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1348662005512 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1348662005513 active pocket/dimerization site; other site 1348662005514 active site 1348662005515 phosphorylation site [posttranslational modification] 1348662005516 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1348662005517 active site 1348662005518 phosphorylation site [posttranslational modification] 1348662005519 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1348662005520 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 1348662005521 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1348662005522 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1348662005523 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1348662005524 SdpI/YhfL protein family; Region: SdpI; pfam13630 1348662005525 anthranilate synthase component I; Provisional; Region: PRK13564 1348662005526 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1348662005527 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1348662005528 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1348662005529 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1348662005530 glutamine binding [chemical binding]; other site 1348662005531 catalytic triad [active] 1348662005532 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1348662005533 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1348662005534 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1348662005535 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1348662005536 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1348662005537 active site 1348662005538 ribulose/triose binding site [chemical binding]; other site 1348662005539 phosphate binding site [ion binding]; other site 1348662005540 substrate (anthranilate) binding pocket [chemical binding]; other site 1348662005541 product (indole) binding pocket [chemical binding]; other site 1348662005542 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1348662005543 active site 1348662005544 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1348662005545 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1348662005546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1348662005547 catalytic residue [active] 1348662005548 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1348662005549 substrate binding site [chemical binding]; other site 1348662005550 active site 1348662005551 catalytic residues [active] 1348662005552 heterodimer interface [polypeptide binding]; other site 1348662005553 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1348662005554 iron-sulfur cluster [ion binding]; other site 1348662005555 [2Fe-2S] cluster binding site [ion binding]; other site 1348662005556 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1348662005557 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1348662005558 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1348662005559 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1348662005560 active site 1348662005561 NTP binding site [chemical binding]; other site 1348662005562 metal binding triad [ion binding]; metal-binding site 1348662005563 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1348662005564 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1348662005565 Zn2+ binding site [ion binding]; other site 1348662005566 Mg2+ binding site [ion binding]; other site 1348662005567 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1348662005568 active site 1348662005569 Ap6A binding site [chemical binding]; other site 1348662005570 nudix motif; other site 1348662005571 metal binding site [ion binding]; metal-binding site 1348662005572 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1348662005573 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1348662005574 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1348662005575 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1348662005576 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1348662005577 DNA binding residues [nucleotide binding] 1348662005578 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1348662005579 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1348662005580 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1348662005581 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1348662005582 catalytic residues [active] 1348662005583 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1348662005584 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1348662005585 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1348662005586 active site 1348662005587 metal binding site [ion binding]; metal-binding site 1348662005588 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1348662005589 ParB-like nuclease domain; Region: ParBc; pfam02195 1348662005590 KorB domain; Region: KorB; pfam08535 1348662005591 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1348662005592 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1348662005593 P-loop; other site 1348662005594 Magnesium ion binding site [ion binding]; other site 1348662005595 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1348662005596 Magnesium ion binding site [ion binding]; other site 1348662005597 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1348662005598 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1348662005599 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1348662005600 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1348662005601 Haemolytic domain; Region: Haemolytic; pfam01809 1348662005602 Ribonuclease P; Region: Ribonuclease_P; cl00457