-- dump date 20140619_050528 -- class Genbank::CDS -- table cds_note -- id note YP_001950244.1 ORF1 YP_001950245.1 ORF2 YP_001950247.1 ORF3 YP_001950249.1 ORF4 YP_001950250.1 ORF5 YP_001950251.1 ORF6 YP_001950252.1 ORF7 YP_001950253.1 ORF8 YP_001950254.1 ORF9 YP_001950255.1 ORF10 YP_002833538.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_002833539.1 binds the polymerase to DNA and acts as a sliding clamp YP_002833540.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_002833541.1 Zn-ribbon-containing, possibly RNA-binding protein and truncated derivatives YP_002833542.1 negatively supercoils closed circular double-stranded DNA YP_002833546.1 negatively supercoils closed circular double-stranded DNA YP_002833550.1 Predicted xylanase/chitin deacetylase YP_002833551.1 Histone acetyltransferase HPA2 and related acetyltransferases YP_002833552.1 ABC-type multidrug transport system ATPase and permease components YP_002833553.1 ABC-type multidrug transport system ATPase and permease components YP_002833555.1 ATPase involved in DNA repair YP_002833556.1 510-methylenetetrahydrofolate reductase YP_002833557.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_002833558.1 Predicted hydrolase (HAD superfamily) YP_002833559.1 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family YP_002833560.1 Uncharacterized membrane protein (homolog of Drosophila rhomboid) YP_002833562.1 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain YP_002833564.1 Signal transduction histidine kinase YP_002833565.1 integral membrane protein involved in inhibition of the Z-ring formation YP_002833566.1 Serine/threonine protein kinase YP_002833567.1 Serine/threonine protein kinase YP_002833568.1 Cell division protein FtsI/penicillin-binding protein 2 YP_002833569.1 Bacterial cell division membrane protein YP_002833571.1 FOG: FHA domain YP_002833575.1 Transposase and inactivated derivatives YP_002833576.1 Transposase and inactivated derivatives YP_002833577.1 Transposase and inactivated derivatives YP_002833579.1 Transposase and inactivated derivatives YP_002833580.1 Transposase and inactivated derivatives YP_002833581.1 Transposase and inactivated derivatives YP_002833584.1 Uncharacterized conserved protein YP_002833585.1 Transposase and inactivated derivatives YP_002833586.1 Transposase and inactivated derivatives YP_002833587.1 Acetyltransferase (isoleucine patch superfamily) YP_002833589.1 Transposase and inactivated derivatives YP_002833590.1 Transposase and inactivated derivatives YP_002833593.1 Transposase and inactivated derivatives YP_002833596.1 Transposase and inactivated derivatives YP_002833597.1 Transposase and inactivated derivatives YP_002833599.1 Uncharacterized conserved protein YP_002833602.1 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold YP_002833603.1 Uncharacterized conserved protein YP_002833605.1 Acetylornithine deacetylase/Succinyl- diaminopimelate desuccinylase and related deacylases YP_002833606.1 catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine YP_002833608.1 NAD-dependent protein deacetylases, SIR2 family YP_002833609.1 Uncharacterized protein conserved in bacteria YP_002833610.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile YP_002833611.1 Predicted phosphoribosyltransferases YP_002833612.1 Sulfate permease and related transporters (MFS superfamily) YP_002833613.1 Ferritin-like protein YP_002833615.1 Predicted hydrolase (HAD superfamily) YP_002833616.1 Transcriptional regulator/sugar kinase YP_002833617.1 Predicted Rossmann fold nucleotide-binding protein YP_002833618.1 Uncharacterized protein conserved in bacteria YP_002833619.1 ammonia monooxygenase YP_002833620.1 Predicted permeases YP_002833621.1 HrpA-like helicases YP_002833622.1 Acetyltransferase (isoleucine patch superfamily) YP_002833623.1 Short-chain alcohol dehydrogenase of unknown specificity YP_002833624.1 NAD-dependent aldehyde dehydrogenases YP_002833625.1 Choline-glycine betaine transporter YP_002833626.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine YP_002833627.1 threonine efflux protein YP_002833628.1 Uncharacterized conserved protein YP_002833629.1 Predicted enzyme related to lactoylglutathione lyase YP_002833632.1 Transposase and inactivated derivatives YP_002833633.1 Predicted membrane protein YP_002833635.1 Predicted metalloendopeptidase YP_002833636.1 Esterase/lipase YP_002833639.1 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002833640.1 FAD/FMN-containing dehydrogenases YP_002833644.1 Predicted membrane protein YP_002833645.1 Predicted membrane protein YP_002833646.1 Predicted glycosyltransferases YP_002833649.1 Acetyltransferases, including N-acetylases of ribosomal proteins YP_002833650.1 ABC-type polysaccharide/polyol phosphate transport system ATPase component YP_002833651.1 ABC-type polysaccharide/polyol phosphate export systems permease component YP_002833652.1 Selenocysteine lyase YP_002833653.1 NADPH:quinone reductase and related Zn- dependent oxidoreductases YP_002833654.1 Thioredoxin reductase YP_002833657.1 Modulates the activities of several enzymes which are inactive in their acetylated form YP_002833661.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase YP_002833663.1 Molybdopterin biosynthesis enzymes YP_002833664.1 Molybdopterin biosynthesis enzyme YP_002833665.1 Molybdopterin converting factor, small subunit YP_002833666.1 Predicted membrane protein YP_002833668.1 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] YP_002833669.1 Gamma-aminobutyrate permease and related permeases YP_002833670.1 Regulator of polyketide synthase expression YP_002833674.1 Transcriptional regulator YP_002833676.1 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_002833677.1 Mn2+ and Fe2+ transporters of the NRAMP family YP_002833678.1 Predicted membrane protein YP_002833679.1 Predicted membrane protein YP_002833680.1 Trk-type K+ transport systems membrane components YP_002833681.1 K+ transport systems NAD-binding component YP_002833682.1 Vacuolar transporter chaperone YP_002833684.1 Di- and tricarboxylate transporters YP_002833687.1 Kef-type K+ transport systems membrane components YP_002833688.1 Trypsin-like serine proteases typically periplasmic contain C-terminal PDZ domain YP_002833690.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate YP_002833693.1 Predicted drug exporters of the RND superfamily YP_002833694.1 Queuine/archaeosine tRNA-ribosyltransferase YP_002833696.1 Uncharacterized conserved protein YP_002833697.1 PPE-repeat proteins YP_002833698.1 FOG: Glucan-binding domain (YG repeat) YP_002833701.1 Type V secretory pathway, adhesin AidA YP_002833706.1 Glutamyl- and glutaminyl-tRNA synthetases YP_002833708.1 Transposase and inactivated derivatives YP_002833709.1 Aspartate/tyrosine/aromatic aminotransferase YP_002833711.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_002833712.1 Uncharacterized protein conserved in bacteria YP_002833713.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_002833714.1 Rhs family protein YP_002833715.1 Predicted glutamine amidotransferase YP_002833717.1 3'-5' exonuclease of DNA polymerase III YP_002833718.1 Outer membrane protein/protective antigen OMA87 YP_002833719.1 Isopropylmalate/homocitrate/citramalatesynthases YP_002833720.1 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family YP_002833721.1 Permeases of the drug/metabolite transporter (DMT) superfamily YP_002833722.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_002833723.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_002833724.1 Predicted outer membrane protein YP_002833725.1 Predicted outer membrane protein YP_002833726.1 Sortase (surface protein transpeptidase) YP_002833727.1 Sortase (surface protein transpeptidase) YP_002833728.1 Superfamily II DNA and RNA helicases YP_002833729.1 Uncharacterized membrane protein YP_002833730.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_002833732.1 Predicted membrane protein YP_002833733.1 AAA ATPase containing von Willebrand factor type A (vWA) domain YP_002833736.1 Predicted phosphohydrolases YP_002833737.1 Uncharacterized conserved protein YP_002833738.1 Membrane carboxypeptidase (penicillin-binding protein) YP_002833741.1 Zn-dependent hydrolases including glyoxylases YP_002833742.1 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases YP_002833743.1 Predicted EndoIII-related endonuclease YP_002833744.1 Thiol-disulfide isomerase and thioredoxins YP_002833745.1 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_002833746.1 Trypsin-like serine proteases typically periplasmic contain C-terminal PDZ domain YP_002833747.1 DNA-directed RNA polymerase, beta subunit/140 kD subunit YP_002833749.1 ATPase components of various ABC-type transport systems, contain duplicated ATPase YP_002833750.1 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_002833751.1 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_002833752.1 ABC-type oligopeptide transport system, periplasmic component YP_002833753.1 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_002833757.1 ATPases involved in chromosome partitioning YP_002833759.1 Flp pilus assembly protein TadB YP_002833760.1 Flp pilus assembly protein TadC YP_002833764.1 Distinct helicase with a unique C- terminal domain including a metal-binding cysteine cluster YP_002833765.1 Cold shock proteins YP_002833766.1 Uncharacterized membrane-associated protein YP_002833767.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_002833768.1 Predicted membrane protein YP_002833769.1 Adenylate cyclase 3 (some proteins contain HAMP domain) YP_002833770.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_002833772.1 Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_002833773.1 Hydrolases of the alpha/beta superfamily YP_002833775.1 6-phosphogluconolactonase/Glucosamine-6- phosphate isomerase/deaminase YP_002833776.1 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific YP_002833777.1 activates fatty acids by binding to coenzyme A YP_002833779.1 Zn-dependent alcohol dehydrogenases class III YP_002833780.1 Zn-dependent hydrolases including glyoxylases YP_002833781.1 Thiol:disulfide interchange protein YP_002833782.1 Protein-disulfide isomerase YP_002833783.1 dTDP-glucose pyrophosphorylase YP_002833786.1 dTDP-D-glucose 46-dehydratase YP_002833787.1 Aminopeptidase N YP_002833788.1 Predicted esterase YP_002833789.1 Predicted esterase YP_002833791.1 E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component YP_002833793.1 Predicted transcriptional regulator YP_002833795.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_002833796.1 Succinate dehydrogenase/fumarate reductase Fe-S protein YP_002833799.1 DNA or RNA helicases of superfamily II YP_002833800.1 Type II restriction enzyme, methylase subunits YP_002833801.1 Transposase and inactivated derivatives YP_002833802.1 Transposase and inactivated derivatives YP_002833803.1 Type II restriction enzyme, methylase subunits YP_002833804.1 Predicted membrane protein YP_002833805.1 Uncharacterized membrane protein, required for colicin V production YP_002833811.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_002833812.1 LuxS protein involved in autoinducer AI2 synthesis YP_002833813.1 Predicted membrane protein YP_002833814.1 3-oxoacyl-(acyl-carrier-protein) synthase YP_002833815.1 Uncharacterized conserved protein YP_002833816.1 Uncharacterized conserved protein YP_002833817.1 Enoyl reductase domain of yeast-type FAS1 YP_002833819.1 activates fatty acids by binding to coenzyme A YP_002833820.1 activates fatty acids by binding to coenzyme A YP_002833821.1 Predicted glycosyltransferases YP_002833822.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_002833823.1 Signal transduction histidine kinase YP_002833824.1 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002833826.1 Exopolyphosphatase YP_002833827.1 Type V secretory pathway, adhesin AidA YP_002833828.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_002833830.1 Restriction endonuclease YP_002833831.1 Restriction endonuclease YP_002833832.1 Uncharacterized conserved protein YP_002833833.1 Phosphoserine phosphatase YP_002833834.1 Thiol-disulfide isomerase and thioredoxins YP_002833835.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_002833836.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_002833837.1 Uroporphyrinogen-III synthase YP_002833838.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_002833839.1 Amino acid transporters YP_002833841.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_002833842.1 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX YP_002833843.1 Uncharacterized protein conserved in bacteria YP_002833844.1 Antitoxin of toxin-antitoxin stability system YP_002833845.1 ATPase components of various ABC-type transport systems, contain duplicated ATPase YP_002833847.1 ABC-type sugar transport systems, ATPase components YP_002833850.1 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases YP_002833851.1 Uncharacterized protein potentially involved in peptidoglycan biosynthesis YP_002833852.1 Site-specific recombinases, DNA invertase Pin homologs YP_002833853.1 Phytoene dehydrogenase and related proteins YP_002833854.1 ABC-type antimicrobial peptide transport system, permease component YP_002833855.1 ABC-type spermidine/putrescine transport systems, ATPase components YP_002833856.1 Membrane-fusion protein YP_002833857.1 Outer membrane protein/protective antigen OMA87 YP_002833858.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_002833859.1 Fructose-26-bisphosphatase YP_002833860.1 Thiol-disulfide isomerase and thioredoxins YP_002833861.1 Cytochrome c biogenesis protein YP_002833862.1 ResB protein required for cytochrome c biosynthesis YP_002833863.1 ABC-type transport system involved in cytochrome c biogenesis permease component YP_002833867.1 14-dihydroxy-2-naphthoateoctaprenyltransferase YP_002833868.1 ABC-type Mn2+/Zn2+ transport systems, permease components YP_002833869.1 ABC-type Mn2+/Zn2+ transport systems, permease components YP_002833870.1 ABC-type Mn/Zn transport systems ATPase component YP_002833871.1 ABC-type metal ion transport system, periplasmic component/surface adhesin YP_002833872.1 Mn-dependent transcriptional regulator YP_002833873.1 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II YP_002833875.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_002833878.1 C4-dicarboxylate transporter YP_002833879.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate YP_002833880.1 Excinuclease ATPase subunit YP_002833882.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis YP_002833884.1 Predicted glycosyltransferases YP_002833885.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_002833886.1 Dehydrogenases (flavoproteins) YP_002833887.1 Geranylgeranyl pyrophosphate synthase YP_002833888.1 Predicted glutathione S-transferase YP_002833889.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_002833890.1 Modulates Rho-dependent transcription termination YP_002833891.1 Ribosomal protein L11 YP_002833892.1 Ribosomal protein L1 YP_002833893.1 Diaminopimelate decarboxylase YP_002833894.1 Uncharacterized protein conserved in bacteria YP_002833895.1 Cysteine synthase YP_002833896.1 Siderophore-interacting protein YP_002833897.1 ABC-type Fe3+-hydroxamate transport system periplasmic component YP_002833898.1 ABC-type Fe3+-siderophore transport system permease component YP_002833899.1 ABC-type enterobactin transport system permease component YP_002833900.1 ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components YP_002833901.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_002833902.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_002833903.1 Plasmid maintenance system antidote protein YP_002833905.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_002833906.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_002833909.1 Predicted membrane protein YP_002833910.1 ATPase components of various ABC-type transport systems, contain duplicated ATPase YP_002833911.1 ABC-type cobalt transport system, permease component CbiQ and related transporters YP_002833912.1 Adenylate kinase and related kinases YP_002833913.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_002833914.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_002833915.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_002833916.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_002833918.1 Predicted restriction endonuclease YP_002833921.1 Uncharacterized protein conserved in bacteria YP_002833924.1 Uncharacterized protein conserved in bacteria YP_002833925.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_002833926.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_002833927.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_002833928.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_002833929.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_002833930.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_002833931.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_002833932.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_002833933.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_002833934.1 Ribosomal protein L29 YP_002833935.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_002833938.1 Sugar kinases, ribokinase YP_002833939.1 Beta-fructosidases (levanase/invertase) YP_002833940.1 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific YP_002833942.1 Predicted GTPases (dynamin-related) YP_002833943.1 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase YP_002833944.1 Phosphatidylglycerophosphate synthase YP_002833945.1 Glycosyltransferases involved in cell wall biogenesis YP_002833947.1 Glycosyltransferases involved in cell wall biogenesis YP_002833950.1 Membrane protein involved in the export of O- antigen and teichoic acid YP_002833951.1 Uncharacterized protein contain chitin-binding domain type 3 YP_002833952.1 Teichoic acid biosynthesis proteins YP_002833953.1 Sugar transferases involved in lipopolysaccharide synthesis YP_002833954.1 Transposase and inactivated derivatives YP_002833955.1 Transposase and inactivated derivatives YP_002833956.1 Transposase and inactivated derivatives YP_002833957.1 Transposase and inactivated derivatives YP_002833958.1 Transposase and inactivated derivatives YP_002833959.1 Ribosomal protein L14 YP_002833960.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_002833961.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_002833962.1 Formate/nitrite family of transporters YP_002833963.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_002833965.1 Ribosomal protein S8 YP_002833966.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_002833967.1 binds 5S rRNA along with protein L5 and L25 YP_002833968.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_002833969.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_002833970.1 late assembly protein YP_002833971.1 Cyclopropane fatty acid synthase and related methyltransferases YP_002833972.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_002833973.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_002833974.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_002833975.1 Uncharacterized protein conserved in bacteria YP_002833976.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_002833977.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_002833978.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_002833979.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_002833980.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_002833981.1 is a component of the macrolide binding site in the peptidyl transferase center YP_002833982.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_002833984.1 Subtilisin-like serine proteases YP_002833986.1 DNA segregation ATPase FtsK/SpoIIIE and related proteins YP_002833988.1 Uncharacterized protein conserved in bacteria YP_002833990.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_002833991.1 forms a direct contact with the tRNA during translation YP_002833992.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_002833994.1 PPE-repeat proteins YP_002833996.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_002833997.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_002833998.1 Predicted ATPase or kinase YP_002833999.1 Predicted permease YP_002834001.1 Metal-dependent proteases with possible chaperone activity YP_002834002.1 Acetyltransferases YP_002834003.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_002834005.1 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002834006.1 Signal transduction histidine kinase YP_002834007.1 ABC-type sugar transport systems, ATPase components YP_002834009.1 Co-chaperonin GroES (HSP10) YP_002834010.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth YP_002834011.1 ABC-type sugar transport systems, ATPase components YP_002834013.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this protein is involved in expression of ribosome-associated gene products in stationary phase YP_002834014.1 DNA segregation ATPase FtsK/SpoIIIE and related proteins YP_002834016.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_002834017.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_002834018.1 Predicted permease, DMT superfamily YP_002834019.1 Transcriptional regulator YP_002834020.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_002834021.1 Restriction endonuclease YP_002834023.1 stress-responsive transcriptional regulator YP_002834024.1 Signal transduction histidine kinase YP_002834025.1 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002834028.1 Nucleotidyltransferase/DNA polymerase involved in DNA repair YP_002834031.1 ABC-type metal ion transport system permease component YP_002834032.1 ABC-type metal ion transport system ATPase component YP_002834033.1 ABC-type metal ion transport system, periplasmic component/surface antigen YP_002834034.1 ABC-type metal ion transport system periplasmic component/surface antigen YP_002834035.1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase. YP_002834038.1 Uncharacterized conserved protein YP_002834039.1 Predicted membrane protein YP_002834041.1 Fe2+ transport system protein B YP_002834043.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002834044.1 Predicted rRNA methylase (SpoU class) YP_002834045.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_002834047.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine YP_002834048.1 catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol YP_002834049.1 Predicted Zn-dependent hydrolases of the beta- lactamase fold YP_002834050.1 Thiol-disulfide isomerase and thioredoxins YP_002834052.1 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog YP_002834054.1 Transcriptional regulators containing a DNA- binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs YP_002834055.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate YP_002834056.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate YP_002834057.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_002834058.1 Restriction endonuclease YP_002834059.1 Zn-dependent oligopeptidases YP_002834061.1 Monomeric isocitrate dehydrogenase YP_002834062.1 Permeases of the major facilitator superfamily YP_002834063.1 Exonuclease III YP_002834065.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002834066.1 Predicted membrane protein YP_002834067.1 Predicted membrane protein/domain YP_002834070.1 Cell wall-associated hydrolases (invasion- associated proteins) YP_002834072.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_002834074.1 catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity YP_002834075.1 Homoserine acetyltransferase YP_002834076.1 Predicted transcriptional regulator YP_002834077.1 Uncharacterized protein involved in propionate catabolism YP_002834078.1 PEP phosphonomutase and related enzymes YP_002834079.1 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate YP_002834081.1 ABC-type sugar transport systems, ATPase components YP_002834082.1 Transposase and inactivated derivatives YP_002834084.1 Transposase and inactivated derivatives YP_002834085.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate YP_002834086.1 DNA replication protein YP_002834087.1 Transposase and inactivated derivatives YP_002834088.1 Histone acetyltransferase HPA2 and related acetyltransferases YP_002834090.1 Acetyl/propionyl-CoA carboxylase alpha subunit YP_002834091.1 Rhodanese-related sulfurtransferase YP_002834093.1 PPE-repeat proteins YP_002834095.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_002834097.1 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) YP_002834098.1 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) YP_002834100.1 Glycosidases YP_002834102.1 ABC-type sugar transport system, permease component YP_002834103.1 ABC-type sugar transport systems, permease components YP_002834104.1 ABC-type sugar transport system, periplasmic component YP_002834105.1 ABC-type sugar transport systems, ATPase components YP_002834107.1 Biotin-(acetyl-CoA carboxylase) ligase YP_002834109.1 Alpha-acetolactate decarboxylase YP_002834110.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_002834111.1 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase YP_002834112.1 Sugar kinases ribokinase YP_002834114.1 Ribonuclease HI YP_002834115.1 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog YP_002834117.1 Transcriptional regulator YP_002834118.1 Acyl-CoA dehydrogenases YP_002834121.1 Acetyl-CoA acetyltransferase YP_002834123.1 Uncharacterized conserved protein YP_002834124.1 Transcriptional regulators YP_002834125.1 Acetyl/propionyl-CoA carboxylase alpha subunit YP_002834127.1 Uncharacterized proteins homologs of lactam utilization protein B YP_002834132.1 Guanosine polyphosphate pyrophosphohydrolases/synthetases YP_002834133.1 Uncharacterized protein conserved in bacteria YP_002834134.1 Predicted ATPase (AAA+ superfamily) YP_002834138.1 Amino acid permeases YP_002834139.1 Arginine deiminase YP_002834141.1 Uncharacterized protein conserved in bacteria YP_002834142.1 Acetyltransferases, including N-acetylases of ribosomal proteins YP_002834143.1 Uncharacterized conserved protein YP_002834144.1 Dihydrodipicolinate synthase/N- acetylneuraminate lyase YP_002834145.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_002834146.1 Transcriptional regulators YP_002834148.1 ABC-type proline/glycine betaine transport systems, periplasmic components YP_002834149.1 ABC-type proline/glycine betaine transport systems, periplasmic components YP_002834150.1 ABC-type proline/glycine betaine transport system, permease component YP_002834151.1 ABC-type proline/glycine betaine transport system, ATPase component YP_002834152.1 converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines YP_002834154.1 Gluconate kinase YP_002834155.1 H+/gluconate symporter and related permeases YP_002834156.1 Predicted esterase YP_002834159.1 Permeases of the major facilitator superfamily YP_002834160.1 Regulator of polyketide synthase expression YP_002834161.1 Predicted metal-dependent hydrolase with the TIM-barrel fold YP_002834162.1 Acetylornithine deacetylase/Succinyl- diaminopimelate desuccinylase and related deacylases YP_002834163.1 Transcriptional regulators YP_002834164.1 Uncharacterized protein conserved in bacteria YP_002834165.1 Enoyl-CoA hydratase/carnithine racemase YP_002834166.1 Dioxygenases related to 2-nitropropane dioxygenase YP_002834167.1 Predicted thioesterase YP_002834168.1 Acyl-CoA dehydrogenases YP_002834170.1 Zn-dependent alcohol dehydrogenases, class III YP_002834171.1 Sugar diacid utilization regulator YP_002834172.1 N-methylhydantoinase B/acetone carboxylase, alpha subunit YP_002834173.1 N-methylhydantoinase A/acetone carboxylase, beta subunit YP_002834175.1 Uncharacterized membrane protein YP_002834176.1 Esterase/lipase YP_002834177.1 Predicted flavoprotein involved in K+ transport YP_002834178.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_002834179.1 Regulator of polyketide synthase expression YP_002834180.1 Regulator of polyketide synthase expression YP_002834181.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_002834182.1 Amino acid permeases YP_002834183.1 Uncharacterized protein conserved in bacteria YP_002834184.1 NAD-dependent aldehyde dehydrogenases YP_002834185.1 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase YP_002834186.1 Amino acid permeases YP_002834187.1 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] YP_002834188.1 Transcriptional regulator YP_002834190.1 Predicted permeases YP_002834193.1 Predicted glycosyltransferases YP_002834194.1 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B gamma/epsilon subunits (eIF- 2Bgamma/eIF-2Bepsilon) YP_002834198.1 converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells YP_002834199.1 NADPH-dependent glutamate synthase beta chain and related oxidoreductases YP_002834200.1 Sulfite reductase beta subunit (hemoprotein) YP_002834201.1 Uncharacterized conserved protein YP_002834202.1 Predicted permeases YP_002834205.1 Phosphomannose isomerase YP_002834206.1 Exoribonuclease R YP_002834208.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_002834209.1 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002834210.1 Signal transduction histidine kinase YP_002834212.1 Predicted amidophosphoribosyltransferases YP_002834213.1 Ribosome-associated protein Y (PSrp-1) YP_002834214.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_002834216.1 Predicted hydrolase (HAD superfamily) YP_002834220.1 Predicted GTPases YP_002834221.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_002834222.1 Uncharacterized conserved protein YP_002834223.1 Uncharacterized conserved protein YP_002834224.1 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog YP_002834229.1 Superfamily II DNA and RNA helicases YP_002834233.1 Superfamily I DNA and RNA helicases YP_002834234.1 Superfamily I DNA and RNA helicases YP_002834235.1 Kef-type K+ transport systems predicted NAD- binding component YP_002834236.1 NTP pyrophosphohydrolases containing a Zn- finger, probably nucleic-acid-binding YP_002834237.1 Superfamily I DNA and RNA helicases YP_002834239.1 Predicted metal-dependent hydrolase YP_002834240.1 Uncharacterized conserved protein YP_002834244.1 Uncharacterized conserved protein YP_002834245.1 Predicted dinucleotide-utilizing enzyme YP_002834246.1 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain YP_002834247.1 Uncharacterized protein conserved in bacteria YP_002834248.1 Uncharacterized protein conserved in bacteria YP_002834249.1 Predicted membrane protein YP_002834251.1 ABC-type Fe3+-hydroxamate transport system periplasmic component YP_002834252.1 Siderophore-interacting protein YP_002834253.1 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I- patch acetyltransferase domains) YP_002834256.1 ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components YP_002834257.1 ABC-type Fe3+-hydroxamate transport system, periplasmic component YP_002834258.1 ABC-type enterobactin transport system permease component YP_002834259.1 ABC-type Fe3+-siderophore transport system permease component YP_002834260.1 ABC-type Fe3+-hydroxamate transport system periplasmic component YP_002834261.1 ABC-type Fe3+-hydroxamate transport system, periplasmic component YP_002834262.1 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_002834264.1 Archaeal fructose-16-bisphosphatase and related enzymes of inositol monophosphatase YP_002834265.1 Archaeal fructose-16-bisphosphatase and related enzymes of inositol monophosphatase YP_002834266.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 YP_002834267.1 Predicted ATPase involved in cell division YP_002834268.1 Cell division protein YP_002834269.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_002834270.1 Uncharacterized conserved protein YP_002834271.1 Amino acid permeases YP_002834272.1 Coenzyme F420-dependent N5N10-methylene tetrahydromethanopterin reductase and related flavin- dependent oxidoreductases YP_002834273.1 intracellular protease/amidase YP_002834274.1 p-aminobenzoyl-glutamate transporter YP_002834275.1 Metal- dependentamidase/aminoacylase/carboxypeptidase YP_002834276.1 ABC-type enterochelin transport system periplasmic component YP_002834277.1 ABC-type enterochelin transport system permease component YP_002834278.1 ABC-type enterochelin transport system permease component YP_002834279.1 ABC-type enterochelin transport system ATPase component YP_002834281.1 Transposase and inactivated derivatives YP_002834282.1 Transposase and inactivated derivatives YP_002834283.1 Di- and tricarboxylate transporters YP_002834285.1 Transcriptional regulator YP_002834286.1 Aspartate/tyrosine/aromatic aminotransferase YP_002834288.1 DNA or RNA helicases of superfamily II YP_002834291.1 Transcriptional regulator YP_002834294.1 Cold shock proteins YP_002834296.1 Glutamine cyclotransferase YP_002834298.1 Permeases YP_002834301.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate YP_002834302.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH YP_002834303.1 FKBP-type peptidyl-prolyl cis-trans isomerases 1 YP_002834304.1 Aldo/keto reductases, related to diketogulonate reductase YP_002834305.1 Predicted membrane protein YP_002834306.1 Predicted symporter YP_002834308.1 Aspartate/tyrosine/aromatic aminotransferase YP_002834310.1 Predicted redox protein, regulator of disulfide bond formation YP_002834311.1 Predicted phosphohydrolases YP_002834314.1 Transposase and inactivated derivatives YP_002834315.1 Transposase and inactivated derivatives YP_002834319.1 ABC-type multidrug transport system ATPase and permease components YP_002834320.1 ABC-type multidrug transport system ATPase and permease components YP_002834321.1 ABC-type cobalt transport system ATPase component YP_002834325.1 Glutaredoxin and related proteins YP_002834327.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_002834328.1 3-Phosphoadenosine 5-phosphosulfate (PAPS) 3- phosphatase YP_002834329.1 Lhr-like helicases YP_002834330.1 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases YP_002834331.1 Formamidopyrimidine-DNA glycosylase YP_002834332.1 Predicted membrane protein YP_002834333.1 Predicted restriction endonuclease YP_002834334.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_002834336.1 chorismate mutase YP_002834337.1 Superfamily I DNA and RNA helicases YP_002834338.1 Membrane proteins related to metalloendopeptidases YP_002834339.1 ABC-type antimicrobial peptide transport system, permease component YP_002834340.1 ABC-type sugar transport systems, ATPase components YP_002834341.1 Predicted transcriptional regulators YP_002834342.1 Membrane proteins related to metalloendopeptidases YP_002834345.1 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) YP_002834350.1 Serine/threonine protein kinase YP_002834352.1 Transcriptional regulator YP_002834354.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_002834355.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_002834356.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_002834357.1 Ribosomal protein L28 YP_002834358.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_002834359.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_002834360.1 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002834361.1 Signal transduction histidine kinase YP_002834362.1 Trypsin-like serine proteases typically periplasmic contain C-terminal PDZ domain YP_002834363.1 Molybdopterin biosynthesis enzymes YP_002834365.1 Large-conductance mechanosensitive channel YP_002834367.1 5-formyltetrahydrofolate cyclo-ligase YP_002834368.1 UDP-glucose pyrophosphorylase YP_002834369.1 Molybdopterin biosynthesis enzyme YP_002834370.1 Acetyltransferases including N-acetylases of ribosomal proteins YP_002834371.1 AAA ATPase containing von Willebrand factor type A (vWA) domain YP_002834372.1 3-methyladenine DNA glycosylase YP_002834373.1 Methylated DNA-protein cysteine methyltransferase YP_002834374.1 Predicted membrane protein YP_002834375.1 Predicted integral membrane protein YP_002834376.1 Dolichyl-phosphate-mannose--protein O-mannosyl transferase YP_002834379.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_002834380.1 Permeases of the major facilitator superfamily YP_002834381.1 Plasmid maintenance system antidote protein YP_002834382.1 Sortase and related acyltransferases YP_002834383.1 Mg-dependent DNase YP_002834384.1 Uncharacterized protein conserved in bacteria YP_002834385.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_002834386.1 4-diphosphocytidyl-2C-methyl-D-erythritol 2- phosphate synthase YP_002834388.1 ATPase components of ABC transporters with duplicated ATPase domains YP_002834389.1 Predicted permeases YP_002834392.1 Predicted acyltransferases YP_002834393.1 Predicted hydrolases of the HAD superfamily YP_002834394.1 catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA YP_002834396.1 Glycosyltransferase YP_002834397.1 Nucleoside-diphosphate-sugar epimerases YP_002834399.1 Carbonic anhydrase YP_002834401.1 Predicted esterase of the alpha-beta hydrolase superfamily YP_002834402.1 Predicted permease YP_002834403.1 Acetyl-CoA acetyltransferase YP_002834404.1 Enoyl-CoA hydratase/carnithine racemase YP_002834405.1 Enoyl-CoA hydratase/carnithine racemase YP_002834406.1 Transcriptional regulators YP_002834407.1 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases YP_002834408.1 Transcriptional regulator YP_002834409.1 Acyl-CoA dehydrogenases YP_002834410.1 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002834411.1 Deacetylases, including yeast histone deacetylase and acetoin utilization protein YP_002834412.1 Acyl-CoA synthetase (NDP forming) YP_002834413.1 NAD-dependent aldehyde dehydrogenases YP_002834414.1 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases YP_002834415.1 Transcriptional regulator YP_002834416.1 H+/gluconate symporter and related permeases YP_002834417.1 Predicted acyl-CoA transferases/carnitine dehydratase YP_002834419.1 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002834421.1 Dioxygenases related to 2-nitropropane dioxygenase YP_002834422.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; involved in growth under gluconeogenic conditions and in glycolytic activity at high ATP concentrations in Corynebacterium; NAD and NADP dependent YP_002834423.1 Uncharacterized conserved protein YP_002834425.1 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene- 17-dioic acid hydratase (catechol pathway) YP_002834426.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_002834427.1 Ribosomal protein L25 (general stress protein Ctc) YP_002834428.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_002834429.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_002834431.1 multicopper oxidases YP_002834434.1 Predicted helicases YP_002834439.1 Uncharacterized protein predicted to be involved in DNA repair YP_002834441.1 Predicted membrane protein YP_002834443.1 Transcription-repair coupling factor (superfamily II helicase) YP_002834445.1 Amino acid transporters YP_002834446.1 Predicted pyrophosphatase YP_002834449.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_002834450.1 Septum formation initiator YP_002834451.1 Uncharacterized conserved protein YP_002834452.1 Exopolyphosphatase YP_002834453.1 Predicted membrane protein YP_002834454.1 Transposase and inactivated derivatives YP_002834458.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_002834460.1 Uncharacterized proteins LmbE homologs YP_002834462.1 Undecaprenyl pyrophosphate synthase YP_002834463.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_002834464.1 Glycine/serine hydroxymethyltransferase YP_002834467.1 Predicted ATPase related to phosphate starvation-inducible protein PhoH YP_002834468.1 Sortase and related acyltransferases YP_002834470.1 Permeases of the major facilitator superfamily YP_002834471.1 Transcriptional regulator YP_002834472.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_002834473.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_002834474.1 Uncharacterized membrane protein, required for N-linked glycosylation YP_002834477.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_002834478.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_002834479.1 Gamma-aminobutyrate permease and related permeases YP_002834480.1 Uncharacterized protein conserved in bacteria YP_002834481.1 Predicted permease YP_002834482.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_002834483.1 Metal- dependentamidase/aminoacylase/carboxypeptidase YP_002834484.1 intracellular protease/amidase YP_002834485.1 Predicted Co/Zn/Cd cation transporters YP_002834487.1 NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate YP_002834489.1 FAD/FMN-containing dehydrogenases YP_002834490.1 Permeases of the major facilitator superfamily YP_002834491.1 Large exoproteins involved in heme utilization or adhesion YP_002834492.1 Transposase and inactivated derivatives YP_002834493.1 DNA replication protein YP_002834494.1 Na+/H+-dicarboxylate symporters YP_002834495.1 Lipoate-protein ligase A YP_002834496.1 Uncharacterized protein conserved in bacteria YP_002834497.1 Uncharacterized anaerobic dehydrogenase YP_002834498.1 Anaerobic dehydrogenases, typically selenocysteine-containing YP_002834499.1 Fe-S-cluster-containing hydrogenase components 1 YP_002834500.1 Formate-dependent nitrite reductase, membrane component YP_002834502.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis YP_002834503.1 Selenocysteine-specific translation elongation factor YP_002834504.1 Plasmid maintenance system killer protein YP_002834505.1 Plasmid maintenance system antidote protein YP_002834507.1 Predicted divalent heavy-metal cations transporter YP_002834508.1 Uncharacterized protein conserved in bacteria YP_002834509.1 Uncharacterized conserved protein YP_002834511.1 Predicted membrane GTPase involved in stress response YP_002834513.1 Uncharacterized proteins LmbE homologs YP_002834516.1 catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis YP_002834517.1 Pseudouridylate synthases 23S RNA-specific YP_002834519.1 Predicted transcriptional regulators YP_002834521.1 Gamma-aminobutyrate permease and related permeases YP_002834522.1 Tetrahydrodipicolinate N-succinyltransferase YP_002834523.1 Gamma-aminobutyrate permease and related permeases YP_002834524.1 catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate YP_002834525.1 Predicted Rossmann fold nucleotide-binding protein YP_002834526.1 Dihydropteroate synthase and related enzymes YP_002834527.1 Glycosyltransferases involved in cell wall biogenesis YP_002834530.1 SAM-dependent methyltransferases YP_002834531.1 Beta-fructosidases (levanase/invertase) YP_002834532.1 Predicted glycosyltransferases YP_002834533.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_002834534.1 Predicted O-methyltransferase YP_002834535.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence YP_002834537.1 Sec-independent protein secretion pathway components YP_002834538.1 ATPases involved in chromosome partitioning YP_002834541.1 DNA-directed RNA polymerase, beta subunit/140 kD subunit YP_002834542.1 Transposase and inactivated derivatives YP_002834543.1 DNA replication protein YP_002834544.1 kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth YP_002834546.1 Carboxylesterase type B YP_002834549.1 Transposase YP_002834551.1 Permeases of the major facilitator superfamily YP_002834552.1 DNA or RNA helicases of superfamily II YP_002834553.1 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_002834554.1 catalyzes the formation of glutamate and formamide from N-formimidoyl-L-glutamate YP_002834555.1 Gamma-aminobutyrate permease and related permeases YP_002834556.1 Uncharacterized protein conserved in bacteria YP_002834557.1 Transcriptional regulator YP_002834558.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_002834560.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_002834561.1 catalyzes the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway YP_002834562.1 Superfamily II DNA and RNA helicases YP_002834564.1 Uncharacterized conserved protein YP_002834565.1 Na+/proline symporter YP_002834566.1 Superfamily II DNA/RNA helicases SNF2 family YP_002834567.1 Uncharacterized conserved protein YP_002834568.1 DNA repair exonuclease YP_002834570.1 Transcriptional regulators YP_002834574.1 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_002834575.1 Uncharacterized conserved protein containing a ferredoxin-like domain YP_002834576.1 Uncharacterized conserved protein containing a ferredoxin-like domain YP_002834577.1 Fe-S oxidoreductase YP_002834580.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_002834582.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_002834583.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_002834584.1 Predicted transcriptional regulator YP_002834585.1 ABC-type sugar transport systems, ATPase components YP_002834586.1 ABC-type molybdate transport system, periplasmic component YP_002834587.1 Uncharacterized conserved protein YP_002834589.1 multicopper oxidases YP_002834592.1 Molybdopterin biosynthesis enzyme YP_002834593.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_002834594.1 activates fatty acids by binding to coenzyme A YP_002834595.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_002834596.1 Protein chain release factor A YP_002834597.1 Methylase of polypeptide chain release factors YP_002834599.1 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase YP_002834601.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_002834602.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_002834603.1 F0F1-type ATP synthase subunit b YP_002834604.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_002834605.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_002834606.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_002834607.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_002834608.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_002834614.1 ABC-type oligopeptide transport system, periplasmic component YP_002834615.1 Protein-tyrosine-phosphatase YP_002834616.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_002834617.1 Glycosidases YP_002834618.1 ABC-type molybdenum transport system ATPase component/photorepair protein PhrA YP_002834619.1 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_002834621.1 Electron transfer flavoprotein beta subunit YP_002834622.1 Electron transfer flavoprotein alpha subunit YP_002834623.1 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes YP_002834624.1 Predicted esterase YP_002834625.1 Uncharacterized conserved protein YP_002834627.1 Lyzozyme M1 (14-beta-N-acetylmuramidase) YP_002834629.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_002834631.1 Predicted nucleic acid-binding protein, contains PIN domain YP_002834634.1 Beta-lactamase class C and other penicillin binding proteins YP_002834635.1 Predicted transcriptional regulators YP_002834636.1 3'-5' exonuclease of DNA polymerase III YP_002834637.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_002834638.1 Predicted hydrolases of the HAD superfamily YP_002834639.1 Predicted hydrolases of the HAD superfamily YP_002834641.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_002834642.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_002834643.1 Restriction endonuclease YP_002834646.1 Permeases of the major facilitator superfamily YP_002834647.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_002834648.1 Predicted permease YP_002834649.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_002834650.1 Zn-dependent alcohol dehydrogenases YP_002834651.1 Uncharacterized membrane protein YP_002834652.1 Lysine efflux permease YP_002834653.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport YP_002834656.1 Transposase and inactivated derivatives YP_002834657.1 Transcriptional regulators YP_002834658.1 Predicted integral membrane protein YP_002834659.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_002834661.1 acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate YP_002834662.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_002834663.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_002834664.1 Uncharacterized conserved protein YP_002834666.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_002834667.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_002834668.1 Predicted signal-transduction protein containing cAMP-binding and CBS domains YP_002834669.1 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases YP_002834670.1 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene- 17-dioic acid hydratase (catechol pathway) YP_002834672.1 Surface antigen YP_002834673.1 ABC-type Mn2+/Zn2+ transport systems permease components YP_002834674.1 ABC-type Mn/Zn transport systems ATPase component YP_002834678.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_002834685.1 Transcriptional regulator YP_002834686.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_002834688.1 Predicted integral membrane protein YP_002834689.1 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_002834690.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_002834691.1 D-alanine-D-alanine ligase and related ATP- grasp enzymes YP_002834693.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP YP_002834694.1 Uracil DNA glycosylase YP_002834695.1 Predicted kinase related to dihydroxyacetone kinase YP_002834696.1 RecG-like helicase YP_002834697.1 N6-adenine-specific methylase YP_002834698.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_002834699.1 Predicted permeases YP_002834700.1 Uncharacterized conserved protein YP_002834705.1 Predicted nucleoside-diphosphate sugar epimerase YP_002834706.1 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase YP_002834707.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_002834708.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_002834709.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_002834710.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_002834711.1 type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_002834713.1 Essential for recycling GMP and indirectly, cGMP YP_002834714.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_002834715.1 Phosphopantothenoylcysteinesynthetase/decarboxylase YP_002834716.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_002834717.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_002834718.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_002834719.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_002834720.1 tRNA and rRNA cytosine-C5-methylases YP_002834721.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_002834722.1 Pyrimidine reductase riboflavin biosynthesis YP_002834724.1 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate YP_002834725.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_002834727.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_002834731.1 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase YP_002834732.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_002834733.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_002834735.1 6-phosphogluconolactonase/Glucosamine-6- phosphate isomerase/deaminase YP_002834737.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_002834738.1 catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate YP_002834739.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_002834740.1 converts protoheme IX and farnesyl diphosphate to heme O YP_002834741.1 NADPH:quinone reductase and related Zn- dependent oxidoreductases YP_002834742.1 Uncharacterized protein required for cytochrome oxidase assembly YP_002834743.1 ABC-type multidrug transport system permease component YP_002834744.1 ABC-type multidrug transport system ATPase component YP_002834746.1 Predicted transcriptional regulator YP_002834747.1 ABC-type transport system involved in Fe-S cluster assembly permease component YP_002834748.1 ABC-type transport system involved in Fe-S cluster assembly permease component YP_002834749.1 ABC-type transport system involved in Fe-S cluster assembly ATPase component YP_002834751.1 NifU homolog involved in Fe-S cluster formation YP_002834752.1 Predicted metal-sulfur cluster biosynthetic enzyme YP_002834753.1 Phosphotransferase system, fructose-specific IIC component YP_002834754.1 ATPase components of ABC transporters with duplicated ATPase domains YP_002834755.1 Transposase and inactivated derivatives YP_002834756.1 Transposase and inactivated derivatives YP_002834757.1 Transposase and inactivated derivatives YP_002834759.1 Predicted transcriptional regulators YP_002834761.1 ACT domain-containing protein YP_002834762.1 Predicted nucleoside-diphosphate-sugar epimerases YP_002834766.1 Transcriptional regulator YP_002834767.1 Catalyzes the conversion of citrate to isocitrate YP_002834769.1 Cell wall-associated hydrolases (invasion- associated proteins) YP_002834770.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_002834774.1 Uncharacterized conserved protein YP_002834775.1 Uncharacterized membrane-associated protein YP_002834776.1 Transposase and inactivated derivatives YP_002834778.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_002834780.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_002834781.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_002834783.1 Predicted phosphatase/phosphohexomutase YP_002834784.1 Phosphoribosyl-ATP pyrophosphohydrolase YP_002834785.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors YP_002834786.1 catalyzes the formation of fumarate from aspartate YP_002834787.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB YP_002834788.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate YP_002834790.1 catalyzes the removal of amino acids from the N termini of peptides YP_002834791.1 tRNA(1-methyladenosine) methyltransferase and related methyltransferases YP_002834792.1 ATPases of the AAA+ class YP_002834797.1 Predicted transcriptional regulator YP_002834799.1 Sec-independent protein secretion pathway component TatC YP_002834800.1 Superfamily II RNA helicase YP_002834801.1 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain YP_002834802.1 Xaa-Pro aminopeptidase YP_002834803.1 probable dehydrogenase YP_002834804.1 Sulfite reductase, beta subunit (hemoprotein) YP_002834805.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein YP_002834808.1 ABC-type sugar transport systems, ATPase components YP_002834810.1 Maltose-binding periplasmic proteins/domains YP_002834811.1 ABC-type sugar transport systems, permease components YP_002834812.1 ABC-type sugar transport system, permease component YP_002834816.1 Uncharacterized conserved protein YP_002834818.1 Permeases of the major facilitator superfamily YP_002834819.1 Predicted Na+-dependent transporter YP_002834820.1 FAD/FMN-containing dehydrogenases YP_002834821.1 Cyclopropane fatty acid synthase and related methyltransferases YP_002834822.1 NADH dehydrogenase FAD-containing subunit YP_002834823.1 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase YP_002834824.1 SAM-dependent methyltransferases YP_002834825.1 Mg2+ and Co2+ transporters YP_002834826.1 Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_002834827.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_002834828.1 Restriction endonuclease YP_002834830.1 Superfamily II DNA and RNA helicases YP_002834833.1 Predicted transcriptional regulators YP_002834834.1 Uncharacterized conserved protein YP_002834835.1 Predicted transcriptional regulators YP_002834836.1 FOG: FHA domain YP_002834837.1 SecA2; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond to SecA2; which is non-essential and seems to play a role in secretion of a subset of proteins YP_002834839.1 Uncharacterized protein conserved in bacteria YP_002834840.1 Uncharacterized protein conserved in bacteria YP_002834843.1 Adenine specific DNA methylase Mod YP_002834845.1 SAM-dependent methyltransferases YP_002834846.1 ABC-type multidrug transport system ATPase component YP_002834847.1 ABC-type multidrug transport system permease component YP_002834849.1 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain YP_002834850.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters YP_002834851.1 synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_002834852.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_002834853.1 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases YP_002834856.1 ATPases involved in chromosome partitioning YP_002834858.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_002834861.1 Uncharacterized membrane-anchored protein conserved in bacteria YP_002834862.1 ATPase involved in DNA repair YP_002834863.1 catalyzes the phosphorylation of NAD to NADP YP_002834868.1 Transposase and inactivated derivatives YP_002834869.1 Transposase and inactivated derivatives YP_002834870.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_002834872.1 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain YP_002834874.1 Predicted ornithine cyclodeaminase, mu- crystallin homolog YP_002834875.1 Gamma-aminobutyrate permease and related permeases YP_002834876.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_002834877.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_002834878.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_002834879.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_002834880.1 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine YP_002834881.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_002834882.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_002834883.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_002834885.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_002834886.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_002834887.1 rRNA methylases YP_002834888.1 Predicted membrane protein YP_002834889.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_002834890.1 ribosomal protein L35 YP_002834891.1 Translation initiation factor 3 (IF-3) YP_002834893.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_002834894.1 Zn-dependent hydrolases including glyoxylases YP_002834896.1 Superfamily I DNA and RNA helicases YP_002834897.1 Uncharacterized conserved protein YP_002834898.1 Universal stress protein UspA and related nucleotide-binding proteins YP_002834899.1 Universal stress protein UspA and related nucleotide-binding proteins YP_002834900.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_002834903.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_002834904.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_002834905.1 SAM-dependent methyltransferases YP_002834907.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_002834909.1 Predicted membrane protein YP_002834910.1 ABC-type amino acid transport/signal transduction systems periplasmic component/domain YP_002834911.1 ABC-type amino acid transport system permease component YP_002834912.1 ABC-type polar amino acid transport system ATPase component YP_002834913.1 Transcription termination factor YP_002834914.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_002834915.1 Xaa-Pro aminopeptidase YP_002834916.1 3-dehydroquinate dehydratase II YP_002834917.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_002834918.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_002834919.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_002834921.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_002834922.1 Predicted periplasmic solute-binding protein YP_002834923.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_002834924.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002834927.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_002834929.1 Phosphate/sulphate permeases YP_002834930.1 Predicted transcriptional regulator with C- terminal CBS domains YP_002834931.1 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin- dependent oxidoreductases YP_002834932.1 Predicted flavoprotein YP_002834933.1 L-serine deaminase YP_002834934.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_002834936.1 Peroxiredoxin YP_002834937.1 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family YP_002834941.1 5-nucleotidase/23-cyclic phosphodiesterase and related esterases YP_002834942.1 Guanosine polyphosphate pyrophosphohydrolases/synthetases YP_002834943.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_002834944.1 ABC-type dipeptide transport system periplasmic component YP_002834945.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_002834946.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_002834947.1 Preprotein translocase subunit YajC YP_002834948.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_002834949.1 Holliday junction resolvasome DNA-binding subunit YP_002834950.1 Holliday junction resolvasome endonuclease subunit YP_002834951.1 Nitroreductase YP_002834952.1 Uncharacterized conserved protein YP_002834953.1 Acyl-CoA thioesterase YP_002834956.1 Transposase and inactivated derivatives YP_002834957.1 Transposase and inactivated derivatives YP_002834958.1 Uncharacterized conserved protein YP_002834959.1 Predicted glycosyltransferases YP_002834960.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_002834963.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_002834964.1 Predicted iron-dependent peroxidase YP_002834965.1 Uncharacterized protein conserved in bacteria YP_002834966.1 FOG: PKD repeat YP_002834967.1 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain YP_002834968.1 Tellurite resistance protein and related permeases YP_002834969.1 Pyrimidine reductase, riboflavin biosynthesis YP_002834971.1 Conserved domain frequently associated with peptide methionine sulfoxide reductase YP_002834975.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_002834976.1 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase YP_002834979.1 dUTPase YP_002834982.1 Transcriptional regulator/sugar kinase YP_002834983.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released YP_002834984.1 Uncharacterized protein conserved in bacteria YP_002834986.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase YP_002834990.1 Methylase of polypeptide chain release factors YP_002834991.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_002834992.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase YP_002834993.1 Mn-dependent transcriptional regulator YP_002834997.1 Superfamily II RNA helicase YP_002834998.1 Predicted membrane protein, toxin regulator YP_002835000.1 Uncharacterized membrane protein YP_002835001.1 Uncharacterized conserved protein YP_002835002.1 Peroxiredoxin YP_002835003.1 Transcriptional regulator YP_002835004.1 Predicted integral membrane protein YP_002835005.1 HrpA-like helicases YP_002835008.1 Represses a number of genes involved in the response to DNA damage YP_002835009.1 Transcriptional regulators of sugar metabolism YP_002835010.1 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) YP_002835011.1 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) YP_002835012.1 Phosphotransferase system, fructose-specific IIC component YP_002835013.1 Phosphotransferase system, HPr-related proteins YP_002835014.1 Xanthine/uracil permeases YP_002835015.1 GTPases YP_002835018.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_002835019.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_002835022.1 Histone acetyltransferase HPA2 and related acetyltransferases YP_002835023.1 NADH:flavin oxidoreductases, Old Yellow Enzyme family YP_002835026.1 ABC-type polar amino acid transport system ATPase component YP_002835027.1 ABC-type amino acid transport/signal transduction systems periplasmic component/domain YP_002835028.1 ABC-type amino acid transport system permease component YP_002835029.1 ABC-type amino acid transport system permease component YP_002835030.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_002835031.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_002835032.1 FOG: Transposase and inactivated derivatives YP_002835034.1 Uncharacterized conserved protein YP_002835035.1 ABC-type cobalt transport system ATPase component YP_002835036.1 ABC-type cobalt transport system permease component CbiQ and related transporters YP_002835039.1 Uncharacterized protein (competence- and mitomycin-induced) YP_002835041.1 Uncharacterized protein conserved in bacteria YP_002835042.1 Membrane protein TerC possibly involved in tellurium resistance YP_002835043.1 DNA segregation ATPase FtsK/SpoIIIE and related proteins YP_002835046.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_002835047.1 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor YP_002835048.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_002835049.1 Restriction endonuclease YP_002835052.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_002835053.1 Inosine-uridine nucleoside N-ribohydrolase YP_002835054.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_002835055.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_002835056.1 Phosphopantetheinyl transferase component of siderophore synthetase YP_002835058.1 Na+-driven multidrug efflux pump YP_002835059.1 Exopolyphosphatase-related proteins YP_002835060.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_002835061.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_002835063.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_002835064.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_002835066.1 Predicted membrane protein YP_002835067.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_002835068.1 Uncharacterized protein conserved in bacteria YP_002835070.1 Predicted epimerase, PhzC/PhzF homolog YP_002835071.1 Uncharacterized conserved protein YP_002835072.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_002835073.1 Lysophospholipase YP_002835074.1 catalyzes the reduction of mycothione or glutathione to mycothione or glutathione disulfide YP_002835079.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential YP_002835080.1 Cell division protein FtsI/penicillin-binding protein 2 YP_002835081.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_002835082.1 Predicted membrane-associated Zn-dependent proteases 1 YP_002835083.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_002835086.1 ABC-type multidrug transport system ATPase component YP_002835087.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_002835088.1 Uncharacterized integral membrane protein YP_002835089.1 CDP-diglyceride synthetase YP_002835090.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_002835091.1 Catalyzes the phosphorylation of UMP to UDP YP_002835092.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_002835093.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_002835094.1 Membrane proteins related to metalloendopeptidases YP_002835095.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_002835096.1 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake YP_002835097.1 Predicted ATPase with chaperone activity YP_002835098.1 Predicted endonuclease distantly related to archaeal Holliday junction resolvase YP_002835100.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_002835103.1 Ribosomal protein L19 YP_002835104.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_002835105.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate YP_002835106.1 Glycine/D-amino acid oxidases (deaminating) YP_002835108.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_002835109.1 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 YP_002835110.1 Predicted membrane protein YP_002835111.1 Restriction endonuclease YP_002835112.1 Transcriptional accessory protein YP_002835114.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_002835115.1 Essential for efficient processing of 16S rRNA YP_002835116.1 Mannose-6-phosphate isomerase YP_002835117.1 Transcriptional regulator YP_002835118.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_002835119.1 Predicted acyltransferases YP_002835120.1 Signal recognition particle GTPase YP_002835121.1 Uridylylates and de-uridylylates the small trimeric protein Pii YP_002835122.1 Nitrogen regulatory protein PII YP_002835123.1 Ammonia permease YP_002835124.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_002835125.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_002835126.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_002835127.1 Multisubunit Na+/H+ antiporter, MnhC subunit YP_002835128.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_002835129.1 Signal recognition particle GTPase YP_002835130.1 Chromosome segregation ATPases YP_002835131.1 catalyzes the hydrolysis of acylphosphate YP_002835132.1 Na+/alanine symporter YP_002835134.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_002835135.1 Predicted metal-binding, possibly nucleic acid- binding protein YP_002835138.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_002835139.1 Glycerate kinase YP_002835142.1 Glucan phosphorylase YP_002835143.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002835144.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_002835145.1 Indole-3-glycerol phosphate synthase YP_002835148.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_002835149.1 Archaeal fructose-16-bisphosphatase and related enzymes of inositol monophosphatase YP_002835150.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis YP_002835151.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_002835152.1 Permeases of the major facilitator superfamily YP_002835155.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_002835156.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_002835160.1 Transcriptional regulator YP_002835161.1 Type II secretory pathway pullulanase PulA and related glycosidases YP_002835165.1 Uncharacterized protein conserved in bacteria YP_002835166.1 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) YP_002835168.1 Uncharacterized conserved protein YP_002835169.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic YP_002835170.1 FOG: WD40 repeat YP_002835172.1 Methionine synthase II (cobalamin-independent) YP_002835173.1 Transposase YP_002835174.1 Methionine synthase II (cobalamin-independent) YP_002835175.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_002835176.1 Predicted permeases YP_002835179.1 Pseudouridylate synthases 23S RNA-specific YP_002835180.1 Lipoprotein signal peptidase YP_002835183.1 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D YP_002835184.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_002835185.1 Transcriptional regulators YP_002835186.1 Permeases of the major facilitator superfamily YP_002835187.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin) YP_002835188.1 Restriction endonuclease YP_002835191.1 Predicted integral membrane protein YP_002835192.1 Uncharacterized protein conserved in bacteria YP_002835194.1 Uncharacterized conserved protein YP_002835195.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_002835196.1 Cell division septal protein YP_002835197.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_002835198.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_002835199.1 Bacterial cell division membrane protein YP_002835200.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_002835201.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_002835202.1 UDP-N-acetylmuramyl pentapeptide synthase YP_002835203.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_002835204.1 Cell division protein FtsI/penicillin-binding protein 2 YP_002835206.1 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis YP_002835207.1 Uncharacterized protein conserved in bacteria YP_002835208.1 ABC-type antimicrobial peptide transport system permease component YP_002835209.1 ABC-type antimicrobial peptide transport system ATPase component YP_002835210.1 Transcriptional regulator YP_002835214.1 Geranylgeranyl pyrophosphate synthase YP_002835217.1 Serine/threonine protein kinase YP_002835218.1 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase YP_002835221.1 Predicted membrane protein YP_002835223.1 Transcriptional regulator/sugar kinase YP_002835225.1 Cell wall-associated hydrolases (invasion- associated proteins) YP_002835226.1 Cell wall-associated hydrolases (invasion- associated proteins) YP_002835227.1 Cytochrome b subunit of the bc complex YP_002835229.1 Cytochrome c mono- and diheme variants YP_002835230.1 Heme/copper-type cytochrome/quinol oxidase subunit 3 YP_002835232.1 Heme/copper-type cytochrome/quinol oxidases subunit 2 YP_002835233.1 Asparagine synthase (glutamine-hydrolyzing) YP_002835234.1 Uncharacterized conserved protein YP_002835236.1 NaMN:DMB phosphoribosyltransferase YP_002835237.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_002835238.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_002835239.1 catalyzes the formation of glutamate from glutamine YP_002835240.1 Amidases related to nicotinamidase YP_002835242.1 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) component and related enzymes YP_002835243.1 Permeases of the major facilitator superfamily YP_002835244.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_002835245.1 Glycine cleavage system T protein (aminomethyltransferase) YP_002835246.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_002835247.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_002835248.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_002835258.1 Tellurite resistance protein and related permeases YP_002835259.1 Heat shock protein YP_002835260.1 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_002835261.1 trypsin-like serine protease YP_002835263.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_002835264.1 Permeases of the major facilitator superfamily YP_002835268.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_002835271.1 Uncharacterized conserved protein YP_002835274.1 Exoribonuclease R YP_002835276.1 Zn-ribbon protein, possibly nucleic acid- binding YP_002835277.1 Uncharacterized conserved protein YP_002835278.1 Protein-tyrosine-phosphatase YP_002835279.1 Uncharacterized conserved protein YP_002835281.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_002835282.1 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_002835283.1 Non-ribosomal peptide synthetase modules and related proteins YP_002835284.1 Predicted sugar phosphatases of the HAD superfamily YP_002835287.1 Outer membrane protein/protective antigen OMA87 YP_002835289.1 ABC-type dipeptide transport system, periplasmic component YP_002835290.1 Predicted membrane protein YP_002835291.1 Predicted ATP-dependent endonuclease of the OLD family YP_002835296.1 Uncharacterized protein conserved in bacteria YP_002835297.1 Uncharacterized protein conserved in bacteria YP_002835303.1 Uncharacterized protein conserved in bacteria YP_002835305.1 Transposase and inactivated derivatives YP_002835307.1 Transcriptional regulators of sugar metabolism YP_002835310.1 Transposase and inactivated derivatives YP_002835311.1 Transposase and inactivated derivatives YP_002835313.1 Predicted UDP-glucose 6-dehydrogenase YP_002835315.1 Glycosyltransferases involved in cell wall biogenesis YP_002835316.1 Glycosyltransferase YP_002835317.1 Glycosyltransferase YP_002835318.1 Glycosyltransferase YP_002835322.1 synthesizes RNA primers at the replication forks YP_002835323.1 Guanyl-specific ribonuclease Sa YP_002835325.1 Predicted phosphohydrolases YP_002835326.1 dGTPase type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate YP_002835330.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002835331.1 Predicted transcriptional regulators YP_002835332.1 Fe2+/Zn2+ uptake regulation proteins YP_002835333.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_002835334.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_002835335.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_002835336.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_002835337.1 Predicted metal-dependent hydrolase YP_002835338.1 Phosphate starvation-inducible protein PhoH predicted ATPase YP_002835339.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_002835340.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_002835341.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons YP_002835342.1 Predicted ATPase YP_002835343.1 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases YP_002835345.1 Hemolysins and related proteins containing CBS domains YP_002835347.1 Long-chain acyl-CoA synthetases (AMP-forming) YP_002835349.1 Carboxylesterase type B YP_002835350.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate YP_002835352.1 ABC-type multidrug transport system ATPase and permease components YP_002835353.1 Bifunctional PLP-dependent enzyme with beta- cystathionase and maltose regulon repressor activities YP_002835354.1 Branched-chain amino acid permeases YP_002835355.1 Coenzyme F420-dependent N5N10-methylene tetrahydromethanopterin reductase and related flavin- dependent oxidoreductases YP_002835356.1 Transcriptional regulators YP_002835357.1 ABC-type dipeptide transport system, periplasmic component YP_002835358.1 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_002835359.1 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_002835360.1 ATPase components of various ABC-type transport systems, contain duplicated ATPase YP_002835361.1 Predicted membrane protein YP_002835364.1 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain YP_002835365.1 Signal transduction histidine kinase YP_002835366.1 Predicted membrane protein YP_002835368.1 Predicted membrane protein YP_002835369.1 Metal- dependentamidase/aminoacylase/carboxypeptidase YP_002835370.1 Predicted esterase YP_002835371.1 Restriction endonuclease YP_002835373.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_002835375.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_002835376.1 Site-specific DNA methylase YP_002835378.1 threonine efflux protein YP_002835379.1 FOG: Ankyrin repeat YP_002835380.1 DNA polymerase III delta subunit YP_002835381.1 Predicted membrane metal-binding protein YP_002835382.1 Transcriptional accessory protein YP_002835383.1 Uncharacterized protein conserved in bacteria YP_002835384.1 Fructose-26-bisphosphatase YP_002835385.1 Uncharacterized homolog of plant Iojap protein YP_002835386.1 Nicotinic acid mononucleotide adenylyltransferase YP_002835390.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_002835394.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_002835395.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_002835396.1 Ribosomal protein L27 YP_002835397.1 Ribosomal protein L21 YP_002835398.1 Ribonucleases G and E YP_002835400.1 Arsenite efflux pump ACR3 and related permeases YP_002835401.1 Predicted transcriptional regulators YP_002835402.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_002835403.1 Esterase/lipase YP_002835405.1 Folylpolyglutamate synthase YP_002835406.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_002835408.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_002835409.1 catalyzes the oxidation of malate to oxaloacetate YP_002835410.1 Transcriptional regulator YP_002835412.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_002835413.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate YP_002835415.1 Nucleoside permease YP_002835416.1 Transcriptional regulator, contains sigma factor-related N-terminal domain YP_002835417.1 binds and unfolds substrates as part of the ClpXP protease YP_002835418.1 Permeases of the major facilitator superfamily YP_002835419.1 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002835420.1 Protease subunit of ATP-dependent Clp proteases YP_002835421.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_002835422.1 Mn-dependent transcriptional regulator YP_002835423.1 Protein involved in ribonucleotide reduction YP_002835424.1 Ribonucleotide reductase alpha subunit YP_002835425.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_002835427.1 Predicted flavoprotein YP_002835428.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_002835431.1 Phage-related tail fibre protein YP_002835435.1 Ribonucleases G and E YP_002835436.1 Type V secretory pathway, adhesin AidA YP_002835441.1 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) YP_002835444.1 Phage-related protein YP_002835452.1 Small-conductance mechanosensitive channel YP_002835460.1 Predicted transcriptional regulators YP_002835466.1 Ribonucleotide reductase, beta subunit YP_002835467.1 dUTPase YP_002835468.1 Holliday junction resolvase YP_002835470.1 DNA modification methylase YP_002835484.1 Predicted alternative thymidylate synthase YP_002835489.1 Uncharacterized protein conserved in bacteria YP_002835493.1 Recombinational DNA repair protein (RecE pathway) YP_002835494.1 Phage-related protein, predicted endonuclease YP_002835496.1 Predicted transcriptional regulators YP_002835497.1 Integrase YP_002835503.1 Negative regulator of beta-lactamase expression YP_002835504.1 Glycerophosphoryl diester phosphodiesterase YP_002835506.1 Chromosome segregation ATPases YP_002835507.1 Chromosome segregation ATPases YP_002835515.1 FOG: PAS/PAC domain YP_002835516.1 Intein/homing endonuclease YP_002835518.1 RecG-like helicase YP_002835522.1 Predicted transcriptional regulators YP_002835523.1 Methionyl-tRNA formyltransferase YP_002835524.1 ABC-type sugar transport systems, ATPase components YP_002835525.1 Predicted transcriptional regulators YP_002835529.1 dUTPase YP_002835540.1 Fumarase YP_002835560.1 Aldo/keto reductases related to diketogulonate reductase YP_002835561.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity YP_002835563.1 Aminopeptidase N YP_002835566.1 Transposase and inactivated derivatives YP_002835567.1 Restriction endonuclease YP_002835568.1 Transcriptional regulators YP_002835569.1 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002835570.1 Uncharacterized protein conserved in bacteria YP_002835571.1 ATPase components of various ABC-type transport systems, contain duplicated ATPase YP_002835572.1 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_002835573.1 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_002835574.1 ABC-type dipeptide transport system, periplasmic component YP_002835575.1 Uncharacterized protein conserved in bacteria YP_002835576.1 Cystathionine beta-lyases/cystathionine gamma- synthases YP_002835577.1 Small-conductance mechanosensitive channel YP_002835579.1 Alanine dehydrogenase YP_002835581.1 Predicted thioesterase YP_002835582.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_002835584.1 Predicted membrane protein YP_002835585.1 Transcriptional regulator YP_002835586.1 Arylsulfatase A and related enzymes YP_002835588.1 Short-chain dehydrogenases of various substrate specificities YP_002835589.1 Na+/alanine symporter YP_002835590.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_002835591.1 Siderophore-interacting protein YP_002835592.1 responsible for recognizing base lesions in the genome and initiating base excision DNA repair YP_002835593.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_002835594.1 catalyzes the interconversion of succinyl-CoA and succinate YP_002835595.1 Uncharacterized protein conserved in bacteria YP_002835597.1 Transposase and inactivated derivatives YP_002835598.1 Transposase and inactivated derivatives YP_002835604.1 Peroxiredoxin YP_002835605.1 Transcriptional regulator YP_002835606.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_002835607.1 ABC-type sugar transport system ATPase component YP_002835608.1 Ribose/xylose/arabinose/galactoside ABC-type transport systems permease components YP_002835609.1 ABC-type sugar transport system periplasmic component YP_002835610.1 Enoyl reductase domain of yeast-type FAS1 YP_002835612.1 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_002835613.1 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_002835614.1 ATPase components of various ABC-type transport systems, contain duplicated ATPase YP_002835615.1 ABC-type dipeptide transport system, periplasmic component YP_002835616.1 Membrane protease subunits, stomatin/prohibitin homologs YP_002835617.1 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_002835618.1 Pyruvate-formate lyase-activating enzyme YP_002835619.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit YP_002835620.1 Pyruvate-formate lyase YP_002835621.1 Xanthine/uracil permeases YP_002835624.1 Transcriptional regulators of sugar metabolism YP_002835626.1 Glucitol operon activator YP_002835627.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_002835628.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_002835630.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_002835631.1 Uncharacterized membrane protein (homolog of Drosophila rhomboid) YP_002835633.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA YP_002835634.1 Uncharacterized protein with SCP/PR1 domains YP_002835635.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate YP_002835636.1 Rad3-related DNA helicases YP_002835637.1 Uncharacterized conserved protein YP_002835639.1 Heme/copper-type cytochrome/quinol oxidases subunit 1 YP_002835640.1 Ribonucleotide reductase beta subunit YP_002835641.1 Transcriptional regulators YP_002835642.1 Catalyzes the rate-limiting step in dNTP synthesis YP_002835643.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF YP_002835644.1 Glutaredoxin and related proteins YP_002835645.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif YP_002835647.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_002835648.1 Restriction endonuclease YP_002835649.1 Fructosamine-3-kinase YP_002835654.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate YP_002835655.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_002835657.1 ABC-type antimicrobial peptide transport system permease component YP_002835658.1 ABC-type antimicrobial peptide transport system ATPase component YP_002835659.1 Phytoene/squalene synthetase YP_002835660.1 Phytoene dehydrogenase and related proteins YP_002835662.1 Mg/Co/Ni transporter MgtE (contains CBS domain) YP_002835665.1 Transposase and inactivated derivatives YP_002835667.1 Transposase and inactivated derivatives YP_002835668.1 Transposase and inactivated derivatives YP_002835669.1 Transposase and inactivated derivatives YP_002835670.1 Transposase and inactivated derivatives YP_002835671.1 Transposase and inactivated derivatives YP_002835672.1 DNA replication protein YP_002835673.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_002835674.1 DNA-binding HTH domain-containing proteins YP_002835677.1 Predicted acetyltransferase YP_002835678.1 Uncharacterized protein conserved in bacteria YP_002835679.1 Acetyl-CoA hydrolase YP_002835681.1 Phosphate uptake regulator YP_002835682.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_002835683.1 ABC-type phosphate transport system permease component YP_002835684.1 ABC-type phosphate transport system permease component YP_002835685.1 ABC-type phosphate transport system periplasmic component YP_002835686.1 Acetyltransferases YP_002835688.1 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase YP_002835690.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate YP_002835691.1 Predicted aminomethyltransferase related to GcvT YP_002835693.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_002835694.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_002835696.1 Acyl-CoA hydrolase YP_002835698.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002835699.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_002835700.1 Acyl-CoA dehydrogenases YP_002835703.1 Predicted esterase YP_002835704.1 Uncharacterized protein conserved in bacteria YP_002835705.1 Uncharacterized NAD(FAD)-dependent dehydrogenases YP_002835708.1 Transposase YP_002835709.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_002835710.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_002835711.1 With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway YP_002835712.1 Predicted extracellular nuclease YP_002835713.1 Restriction endonuclease YP_002835714.1 Predicted deacetylase YP_002835716.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_002835718.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_002835719.1 Phosphoribosylamine-glycine ligase YP_002835721.1 Signal transduction histidine kinase YP_002835722.1 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002835723.1 Predicted transcriptional regulators YP_002835724.1 catalyzes the formation of acetate from pyruvate YP_002835725.1 Permeases of the major facilitator superfamily YP_002835726.1 Transposase and inactivated derivatives YP_002835727.1 Transposase and inactivated derivatives YP_002835728.1 Transcriptional regulator YP_002835729.1 Uncharacterized conserved protein YP_002835731.1 Trehalose-6-phosphate synthase YP_002835734.1 Transcriptional regulators YP_002835735.1 ABC-type metal ion transport system, periplasmic component/surface adhesin YP_002835736.1 ABC-type Mn/Zn transport systems ATPase component YP_002835737.1 ABC-type Mn2+/Zn2+ transport systems permease components YP_002835738.1 Poly(3-hydroxybutyrate) depolymerase YP_002835739.1 ABC-type sugar transport systems, ATPase components YP_002835740.1 ABC-type spermidine/putrescine transport systems, ATPase components YP_002835741.1 rRNA methylases YP_002835742.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_002835743.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_002835744.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_002835745.1 Transcriptional regulators similar to M. xanthus CarD YP_002835747.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_002835749.1 Carbonic anhydrase YP_002835751.1 Uncharacterized conserved protein YP_002835757.1 Co/Zn/Cd efflux system component YP_002835758.1 ATPases with chaperone activity ATP-binding subunit YP_002835760.1 Permeases of the major facilitator superfamily YP_002835762.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_002835764.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis YP_002835765.1 Panthothenate synthetase YP_002835766.1 Uncharacterized conserved protein YP_002835767.1 Type V secretory pathway, adhesin AidA YP_002835769.1 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase YP_002835771.1 Dihydropteroate synthase and related enzymes YP_002835772.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_002835773.1 ATP-dependent Zn proteases YP_002835774.1 Hypoxanthine-guanine phosphoribosyltransferase YP_002835775.1 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control YP_002835776.1 D-alanyl-D-alanine carboxypeptidase (penicillin- binding protein 4) YP_002835779.1 Periplasmic protease YP_002835781.1 ABC-type spermidine/putrescine transport systems, ATPase components YP_002835782.1 Signal transduction histidine kinase YP_002835783.1 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002835784.1 Anthranilate/para-aminobenzoate synthases component I YP_002835785.1 Rhodanese-related sulfurtransferase YP_002835787.1 Transcriptional regulators YP_002835788.1 Uncharacterized conserved protein YP_002835789.1 Uncharacterized conserved protein YP_002835792.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_002835793.1 Predicted membrane protein YP_002835794.1 Acetylornithine deacetylase/Succinyl- diaminopimelate desuccinylase and related deacylases YP_002835795.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_002835796.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_002835797.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_002835798.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_002835799.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_002835800.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_002835802.1 ATP-dependent carboxylate-amine ligase YP_002835805.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_002835807.1 Exonuclease III YP_002835808.1 Phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthases and related enzymes YP_002835809.1 Permeases of the major facilitator superfamily YP_002835811.1 ABC-type multidrug transport system ATPase component YP_002835812.1 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_002835814.1 ABC-type amino acid transport/signal transduction systems periplasmic component/domain YP_002835815.1 Serine/threonine protein kinase YP_002835816.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_002835817.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta YP_002835818.1 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific YP_002835819.1 Transcriptional antiterminator YP_002835821.1 RTX toxins and related Ca2+-binding proteins YP_002835823.1 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) YP_002835824.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_002835828.1 Predicted membrane protein YP_002835829.1 Di- and tricarboxylate transporters YP_002835830.1 Involved in the tartrate degradation pathway YP_002835831.1 Involved in the tartrate degradation pathway YP_002835832.1 AraC-type DNA-binding domain-containing proteins YP_002835833.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_002835835.1 rRNA methylases YP_002835836.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_002835837.1 DNA segregation ATPase FtsK/SpoIIIE and related proteins YP_002835838.1 Rhodanese-related sulfurtransferase YP_002835839.1 ATPases with chaperone activity ATP-binding subunit YP_002835840.1 Transcriptional regulator YP_002835841.1 Na+/glutamate symporter YP_002835842.1 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases YP_002835843.1 Predicted amidohydrolase YP_002835845.1 AraC-type DNA-binding domain-containing proteins YP_002835846.1 NAD-dependent aldehyde dehydrogenases YP_002835847.1 Predicted transcriptional regulators YP_002835848.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_002835849.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_002835850.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_002835851.1 ABC-type spermidine/putrescine transport systems, ATPase components YP_002835852.1 ABC-type Fe3+-siderophore transport system, permease component YP_002835853.1 ABC-type Fe3+-siderophore transport system, permease component YP_002835854.1 ABC-type Fe3+-hydroxamate transport system, periplasmic component YP_002835855.1 NAD-dependent aldehyde dehydrogenases YP_002835856.1 Predicted permease YP_002835857.1 Catalyzes hydrolysis of n-ribosyl-purine into a purine and d-ribose YP_002835862.1 Translation elongation factor EF-1alpha (GTPase) YP_002835863.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_002835864.1 3-phosphoadenosine 5-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes YP_002835865.1 NADPH-dependent glutamate synthase beta chain and related oxidoreductases YP_002835866.1 ABC-type multidrug transport system, ATPase and permease components YP_002835867.1 ABC-type multidrug transport system, ATPase and permease components YP_002835868.1 Fe-S oxidoreductases YP_002835869.1 Kef-type K+ transport systems, membrane components YP_002835871.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_002835873.1 Predicted multitransmembrane protein YP_002835874.1 Predicted UDP-glucose 6-dehydrogenase YP_002835877.1 ABC-type multidrug transport system, ATPase and permease components YP_002835879.1 Beta-glucosidase-related glycosidases YP_002835880.1 Universal stress protein UspA and related nucleotide-binding proteins YP_002835886.1 Predicted glycosyltransferases YP_002835887.1 SAM-dependent methyltransferases YP_002835888.1 catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP YP_002835889.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_002835891.1 Predicted drug exporters of the RND superfamily YP_002835894.1 Restriction endonuclease YP_002835896.1 Acetyl-CoA carboxylase carboxyltransferase component (subunits alpha and beta) YP_002835897.1 Polyketide synthase modules and related proteins YP_002835898.1 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II YP_002835901.1 Predicted esterase YP_002835902.1 Predicted esterase YP_002835904.1 catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate YP_002835905.1 Membrane-associated phospholipid phosphatase YP_002835906.1 Predicted glycosyltransferases YP_002835908.1 Transposase and inactivated derivatives YP_002835912.1 Uncharacterized protein potentially involved in peptidoglycan biosynthesis YP_002835913.1 ABC-type sulfate/molybdate transport systems, ATPase component YP_002835914.1 Transposase and inactivated derivatives YP_002835915.1 Transposase and inactivated derivatives YP_002835916.1 Predicted hydrolases of the HAD superfamily YP_002835917.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP YP_002835918.1 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) YP_002835920.1 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_002835921.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002835922.1 Transcriptional regulators YP_002835924.1 Uncharacterized protein conserved in bacteria YP_002835925.1 Phosphoglycerate mutase 1 YP_002835926.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis YP_002835927.1 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases YP_002835928.1 Predicted metal-dependent membrane protease YP_002835932.1 Converts (S)-lactate and NAD(+) to pyruvate and NADH YP_002835933.1 Predicted membrane protein YP_002835934.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_002835936.1 Carbon starvation protein, predicted membrane protein YP_002835938.1 Oxyanion-translocating ATPase YP_002835939.1 Transcriptional regulator YP_002835940.1 Permeases of the major facilitator superfamily YP_002835945.1 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain YP_002835946.1 Signal transduction histidine kinase YP_002835949.1 Sortase (surface protein transpeptidase) YP_002835950.1 Preprotein translocase subunit YidC YP_002835951.1 Transcriptional regulator YP_002835953.1 Universal stress protein UspA and related nucleotide-binding proteins YP_002835954.1 Pseudouridylate synthases 23S RNA-specific YP_002835957.1 ABC-type multidrug transport system ATPase component YP_002835958.1 Predicted transcriptional regulators YP_002835961.1 Thiol-disulfide isomerase and thioredoxins YP_002835963.1 Cation transport ATPase YP_002835964.1 Permeases of the major facilitator superfamily YP_002835965.1 Glycopeptide antibiotics resistance protein YP_002835966.1 unwinds double stranded DNA YP_002835967.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_002835968.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA YP_002835969.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_002835972.1 Membrane carboxypeptidase (penicillin-binding protein) YP_002835974.1 Transcriptional regulators YP_002835975.1 Universal stress protein UspA and related nucleotide-binding proteins YP_002835977.1 Predicted sulfurtransferase YP_002835978.1 Uncharacterized protein conserved in bacteria YP_002835980.1 Predicted integral membrane protein YP_002835981.1 ABC-type spermidine/putrescine transport systems, ATPase components YP_002835982.1 ABC-type antimicrobial peptide transport system, permease component YP_002835983.1 Signal transduction histidine kinase YP_002835984.1 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002835985.1 Predicted flavoprotein involved in K+ transport YP_002835986.1 Glycopeptide antibiotics resistance protein YP_002835987.1 NADPH:quinone reductase and related Zn- dependent oxidoreductases YP_002835989.1 Na+-dependent transporters of the SNF family YP_002835990.1 proposed role in polysaccahride synthesis YP_002835993.1 Transposase and inactivated derivatives YP_002835995.1 Transposase and inactivated derivatives YP_002835996.1 Transposase and inactivated derivatives YP_002835997.1 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases YP_002835998.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_002835999.1 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases YP_002836001.1 Restriction endonuclease YP_002836002.1 Restriction endonuclease S subunits YP_002836003.1 Type I restriction-modification system methyltransferase subunit YP_002836005.1 Uncharacterized conserved protein YP_002836007.1 Uncharacterized protein conserved in bacteria YP_002836008.1 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen YP_002836011.1 Uncharacterized conserved protein YP_002836012.1 Uncharacterized protein conserved in bacteria YP_002836014.1 Plasmid maintenance system antidote protein YP_002836016.1 Predicted transcriptional regulators YP_002836017.1 Cation transport ATPase YP_002836020.1 NAD-dependent aldehyde dehydrogenases YP_002836021.1 AraC-type DNA-binding domain-containing proteins YP_002836022.1 Monoamine oxidase YP_002836023.1 Amino acid transporters YP_002836024.1 NAD-dependent aldehyde dehydrogenases YP_002836026.1 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene- 1,7-dioic acid hydratase (catechol pathway) YP_002836027.1 Lactoylglutathione lyase and related lyases YP_002836028.1 NAD-dependent aldehyde dehydrogenases YP_002836029.1 Transcriptional regulators YP_002836030.1 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene- 1,7-dioic acid hydratase (catechol pathway) YP_002836031.1 Permeases of the major facilitator superfamily YP_002836032.1 catalyzes the formation of catechol from phenol YP_002836033.1 ABC-type oligopeptide transport system, ATPase component YP_002836034.1 ABC-type uncharacterized transport system, permease component YP_002836035.1 ABC-type uncharacterized transport system, periplasmic component YP_002836036.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_002836037.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity YP_002836038.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_002836039.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate YP_002836040.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_002836041.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_002836043.1 Transposase and inactivated derivatives YP_002836044.1 DNA replication protein YP_002836045.1 Na+/H+-dicarboxylate symporters YP_002836046.1 Phenylpropionate dioxygenase and related ring- hydroxylating dioxygenases, large terminal subunit YP_002836047.1 Predicted Na+-dependent transporter YP_002836051.1 Predicted branched-chain amino acid permease (azaleucine resistance) YP_002836052.1 transcriptional regulator YP_002836053.1 tRNA nucleotidyltransferase/poly(A) polymerase YP_002836055.1 Uncharacterized membrane protein virulence factor YP_002836056.1 Uncharacterized conserved protein YP_002836057.1 Aminopeptidase N YP_002836058.1 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog YP_002836060.1 Thiol-disulfide isomerase and thioredoxins YP_002836061.1 N-acetylmuramoyl-L-alanine amidase YP_002836063.1 Predicted transcriptional regulators YP_002836064.1 ATPases involved in chromosome partitioning YP_002836065.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_002836066.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_002836067.1 RNase P protein component