-- dump date 20140619_050605 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1121353000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121353000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1121353000003 Walker A motif; other site 1121353000004 ATP binding site [chemical binding]; other site 1121353000005 Walker B motif; other site 1121353000006 arginine finger; other site 1121353000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1121353000008 DnaA box-binding interface [nucleotide binding]; other site 1121353000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1121353000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1121353000011 putative DNA binding surface [nucleotide binding]; other site 1121353000012 dimer interface [polypeptide binding]; other site 1121353000013 beta-clamp/clamp loader binding surface; other site 1121353000014 beta-clamp/translesion DNA polymerase binding surface; other site 1121353000015 recombination protein F; Reviewed; Region: recF; PRK00064 1121353000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1121353000017 Walker A/P-loop; other site 1121353000018 ATP binding site [chemical binding]; other site 1121353000019 Q-loop/lid; other site 1121353000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353000021 ABC transporter signature motif; other site 1121353000022 Walker B; other site 1121353000023 D-loop; other site 1121353000024 H-loop/switch region; other site 1121353000025 hypothetical protein; Provisional; Region: PRK00111 1121353000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1121353000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121353000028 ATP binding site [chemical binding]; other site 1121353000029 Mg2+ binding site [ion binding]; other site 1121353000030 G-X-G motif; other site 1121353000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1121353000032 anchoring element; other site 1121353000033 dimer interface [polypeptide binding]; other site 1121353000034 ATP binding site [chemical binding]; other site 1121353000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1121353000036 active site 1121353000037 putative metal-binding site [ion binding]; other site 1121353000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1121353000039 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1121353000040 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1121353000041 Predicted membrane protein [Function unknown]; Region: COG2364 1121353000042 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1121353000043 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1121353000044 DNA gyrase subunit A; Validated; Region: PRK05560 1121353000045 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1121353000046 CAP-like domain; other site 1121353000047 active site 1121353000048 primary dimer interface [polypeptide binding]; other site 1121353000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121353000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121353000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121353000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121353000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121353000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121353000055 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1121353000056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353000057 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121353000058 putative substrate translocation pore; other site 1121353000059 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1121353000060 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1121353000061 metal binding site [ion binding]; metal-binding site 1121353000062 PQQ-like domain; Region: PQQ_2; pfam13360 1121353000063 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1121353000064 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1121353000065 intersubunit interface [polypeptide binding]; other site 1121353000066 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1121353000067 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121353000068 ABC-ATPase subunit interface; other site 1121353000069 dimer interface [polypeptide binding]; other site 1121353000070 putative PBP binding regions; other site 1121353000071 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1121353000072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353000073 Walker A/P-loop; other site 1121353000074 ATP binding site [chemical binding]; other site 1121353000075 Q-loop/lid; other site 1121353000076 ABC transporter signature motif; other site 1121353000077 Walker B; other site 1121353000078 D-loop; other site 1121353000079 H-loop/switch region; other site 1121353000080 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 1121353000081 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1121353000082 putative ligand binding site [chemical binding]; other site 1121353000083 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121353000084 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1121353000085 TM-ABC transporter signature motif; other site 1121353000086 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121353000087 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1121353000088 Walker A/P-loop; other site 1121353000089 ATP binding site [chemical binding]; other site 1121353000090 Q-loop/lid; other site 1121353000091 ABC transporter signature motif; other site 1121353000092 Walker B; other site 1121353000093 D-loop; other site 1121353000094 H-loop/switch region; other site 1121353000095 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1121353000096 active site 1121353000097 Rhomboid family; Region: Rhomboid; pfam01694 1121353000098 phenylhydantoinase; Validated; Region: PRK08323 1121353000099 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1121353000100 tetramer interface [polypeptide binding]; other site 1121353000101 active site 1121353000102 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1121353000103 allantoate amidohydrolase; Reviewed; Region: PRK09290 1121353000104 active site 1121353000105 metal binding site [ion binding]; metal-binding site 1121353000106 dimer interface [polypeptide binding]; other site 1121353000107 potential frameshift: common BLAST hit: gi|399985226|ref|YP_006565574.1| general substrate transporter 1121353000108 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1121353000109 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1121353000110 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121353000111 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1121353000112 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1121353000113 homodimer interface [polypeptide binding]; other site 1121353000114 active site 1121353000115 FMN binding site [chemical binding]; other site 1121353000116 substrate binding site [chemical binding]; other site 1121353000117 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1121353000118 4Fe-4S binding domain; Region: Fer4; pfam00037 1121353000119 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1121353000120 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1121353000121 Na binding site [ion binding]; other site 1121353000122 putative substrate binding site [chemical binding]; other site 1121353000123 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1121353000124 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1121353000125 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1121353000126 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1121353000127 tetrameric interface [polypeptide binding]; other site 1121353000128 NAD binding site [chemical binding]; other site 1121353000129 catalytic residues [active] 1121353000130 hypothetical protein; Provisional; Region: PRK06062 1121353000131 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1121353000132 inhibitor-cofactor binding pocket; inhibition site 1121353000133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353000134 catalytic residue [active] 1121353000135 potential frameshift: common BLAST hit: gi|25028021|ref|NP_738075.1| transposase 1121353000136 MULE transposase domain; Region: MULE; pfam10551 1121353000137 putative septation inhibitor protein; Reviewed; Region: PRK00159 1121353000138 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1121353000139 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1121353000140 active site 1121353000141 ATP binding site [chemical binding]; other site 1121353000142 substrate binding site [chemical binding]; other site 1121353000143 activation loop (A-loop); other site 1121353000144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1121353000145 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121353000146 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121353000147 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121353000148 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1121353000149 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1121353000150 active site 1121353000151 ATP binding site [chemical binding]; other site 1121353000152 substrate binding site [chemical binding]; other site 1121353000153 activation loop (A-loop); other site 1121353000154 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1121353000155 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121353000156 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1121353000157 Protein phosphatase 2C; Region: PP2C; pfam00481 1121353000158 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1121353000159 active site 1121353000160 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1121353000161 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1121353000162 phosphopeptide binding site; other site 1121353000163 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1121353000164 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1121353000165 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1121353000166 phosphopeptide binding site; other site 1121353000167 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1121353000168 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1121353000169 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1121353000170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121353000171 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121353000172 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1121353000173 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1121353000174 putative NAD(P) binding site [chemical binding]; other site 1121353000175 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1121353000176 putative homodimer interface [polypeptide binding]; other site 1121353000177 putative homotetramer interface [polypeptide binding]; other site 1121353000178 putative allosteric switch controlling residues; other site 1121353000179 putative metal binding site [ion binding]; other site 1121353000180 putative homodimer-homodimer interface [polypeptide binding]; other site 1121353000181 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1121353000182 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1121353000183 dimer interface [polypeptide binding]; other site 1121353000184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353000185 catalytic residue [active] 1121353000186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1121353000187 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1121353000188 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1121353000189 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 1121353000190 dimer interface [polypeptide binding]; other site 1121353000191 active site 1121353000192 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121353000193 catalytic residues [active] 1121353000194 substrate binding site [chemical binding]; other site 1121353000195 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 1121353000196 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1121353000197 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1121353000198 MarR family; Region: MarR_2; pfam12802 1121353000199 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1121353000200 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1121353000201 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1121353000202 active site 1121353000203 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1121353000204 DNA photolyase; Region: DNA_photolyase; pfam00875 1121353000205 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1121353000206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121353000207 NAD(P) binding site [chemical binding]; other site 1121353000208 active site 1121353000209 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1121353000210 hydrophobic ligand binding site; other site 1121353000211 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1121353000212 substrate binding pocket [chemical binding]; other site 1121353000213 chain length determination region; other site 1121353000214 substrate-Mg2+ binding site; other site 1121353000215 catalytic residues [active] 1121353000216 aspartate-rich region 1; other site 1121353000217 active site lid residues [active] 1121353000218 aspartate-rich region 2; other site 1121353000219 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1121353000220 active site lid residues [active] 1121353000221 substrate binding pocket [chemical binding]; other site 1121353000222 catalytic residues [active] 1121353000223 substrate-Mg2+ binding site; other site 1121353000224 aspartate-rich region 1; other site 1121353000225 aspartate-rich region 2; other site 1121353000226 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121353000227 phytoene desaturase; Region: crtI_fam; TIGR02734 1121353000228 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1121353000229 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1121353000230 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1121353000231 prenyltransferase; Reviewed; Region: ubiA; PRK13105 1121353000232 UbiA prenyltransferase family; Region: UbiA; pfam01040 1121353000233 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 1121353000234 putative metal binding residues [ion binding]; other site 1121353000235 signature motif; other site 1121353000236 dimer interface [polypeptide binding]; other site 1121353000237 active site 1121353000238 polyP binding site; other site 1121353000239 substrate binding site [chemical binding]; other site 1121353000240 acceptor-phosphate pocket; other site 1121353000241 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1121353000242 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 1121353000243 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 1121353000244 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 1121353000245 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1121353000246 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1121353000247 oligomer interface [polypeptide binding]; other site 1121353000248 metal binding site [ion binding]; metal-binding site 1121353000249 metal binding site [ion binding]; metal-binding site 1121353000250 putative Cl binding site [ion binding]; other site 1121353000251 basic sphincter; other site 1121353000252 hydrophobic gate; other site 1121353000253 periplasmic entrance; other site 1121353000254 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 1121353000255 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1121353000256 siderophore binding site; other site 1121353000257 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1121353000258 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1121353000259 Cl- selectivity filter; other site 1121353000260 Cl- binding residues [ion binding]; other site 1121353000261 pore gating glutamate residue; other site 1121353000262 dimer interface [polypeptide binding]; other site 1121353000263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121353000264 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121353000265 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 1121353000266 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1121353000267 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1121353000268 putative active site [active] 1121353000269 PhoH-like protein; Region: PhoH; pfam02562 1121353000270 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1121353000271 Citrate transporter; Region: CitMHS; pfam03600 1121353000272 Citrate transporter; Region: CitMHS; pfam03600 1121353000273 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1121353000274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121353000275 ATP binding site [chemical binding]; other site 1121353000276 Mg2+ binding site [ion binding]; other site 1121353000277 G-X-G motif; other site 1121353000278 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1121353000279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121353000280 active site 1121353000281 phosphorylation site [posttranslational modification] 1121353000282 intermolecular recognition site; other site 1121353000283 dimerization interface [polypeptide binding]; other site 1121353000284 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1121353000285 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1121353000286 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1121353000287 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1121353000288 NAD(P) binding site [chemical binding]; other site 1121353000289 catalytic residues [active] 1121353000290 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121353000291 GAF domain; Region: GAF; pfam01590 1121353000292 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1121353000293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121353000294 biotin synthase; Validated; Region: PRK06256 1121353000295 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121353000296 FeS/SAM binding site; other site 1121353000297 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1121353000298 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1121353000299 CHY zinc finger; Region: zf-CHY; pfam05495 1121353000300 HTH-like domain; Region: HTH_21; pfam13276 1121353000301 Integrase core domain; Region: rve; pfam00665 1121353000302 Integrase core domain; Region: rve_3; pfam13683 1121353000303 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1121353000304 cytosine deaminase; Provisional; Region: PRK09230 1121353000305 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1121353000306 active site 1121353000307 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1121353000308 NAD-dependent deacetylase; Provisional; Region: PRK05333 1121353000309 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1121353000310 Lipase (class 2); Region: Lipase_2; pfam01674 1121353000311 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1121353000312 Lipase (class 2); Region: Lipase_2; pfam01674 1121353000313 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1121353000314 MarR family; Region: MarR_2; cl17246 1121353000315 AMP nucleosidase; Region: AMP-nucleosdse; TIGR01717 1121353000316 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1121353000317 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1121353000318 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1121353000319 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 1121353000320 NAD(P) binding site [chemical binding]; other site 1121353000321 catalytic residues [active] 1121353000322 benzoate transport; Region: 2A0115; TIGR00895 1121353000323 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1121353000324 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1121353000325 Helix-turn-helix domain; Region: HTH_38; pfam13936 1121353000326 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1121353000327 Integrase core domain; Region: rve; pfam00665 1121353000328 Integrase core domain; Region: rve_3; cl15866 1121353000329 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1121353000330 benzoate transport; Region: 2A0115; TIGR00895 1121353000331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353000332 PaaX-like protein; Region: PaaX; pfam07848 1121353000333 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1121353000334 potential frameshift: common BLAST hit: gi|325965304|ref|YP_004243209.1| 2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase 1121353000335 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121353000336 CoA binding site [chemical binding]; other site 1121353000337 non-LTR RNase HI domain of reverse transcriptases; Region: Rnase_HI_RT_non_LTR; cd09276 1121353000338 RNA/DNA hybrid binding site [nucleotide binding]; other site 1121353000339 active site 1121353000340 benzoate transport; Region: 2A0115; TIGR00895 1121353000341 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1121353000342 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1121353000343 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1121353000344 NAD(P) binding site [chemical binding]; other site 1121353000345 catalytic residues [active] 1121353000346 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 1121353000347 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1121353000348 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1121353000349 amidohydrolase; Region: amidohydrolases; TIGR01891 1121353000350 metal binding site [ion binding]; metal-binding site 1121353000351 Predicted membrane protein [Function unknown]; Region: COG2149 1121353000352 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1121353000353 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1121353000354 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 1121353000355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121353000356 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1121353000357 Walker A motif; other site 1121353000358 ATP binding site [chemical binding]; other site 1121353000359 Walker B motif; other site 1121353000360 arginine finger; other site 1121353000361 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1121353000362 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1121353000363 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1121353000364 polyol permease family; Region: 2A0118; TIGR00897 1121353000365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353000366 putative substrate translocation pore; other site 1121353000367 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1121353000368 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1121353000369 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1121353000370 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1121353000371 D-xylulose kinase; Region: XylB; TIGR01312 1121353000372 nucleotide binding site [chemical binding]; other site 1121353000373 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1121353000374 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1121353000375 active site 1121353000376 ATP-binding site [chemical binding]; other site 1121353000377 pantoate-binding site; other site 1121353000378 HXXH motif; other site 1121353000379 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1121353000380 oligomerization interface [polypeptide binding]; other site 1121353000381 active site 1121353000382 metal binding site [ion binding]; metal-binding site 1121353000383 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1121353000384 active site 1121353000385 DNA binding site [nucleotide binding] 1121353000386 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 1121353000387 dimer interface [polypeptide binding]; other site 1121353000388 FMN binding site [chemical binding]; other site 1121353000389 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1121353000390 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1121353000391 substrate binding pocket [chemical binding]; other site 1121353000392 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1121353000393 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1121353000394 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121353000395 motif II; other site 1121353000396 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1121353000397 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1121353000398 trimer interface [polypeptide binding]; other site 1121353000399 putative metal binding site [ion binding]; other site 1121353000400 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121353000401 putative DNA binding site [nucleotide binding]; other site 1121353000402 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1121353000403 enterobactin exporter EntS; Provisional; Region: PRK10489 1121353000404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353000405 putative substrate translocation pore; other site 1121353000406 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1121353000407 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1121353000408 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1121353000409 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1121353000410 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1121353000411 Predicted membrane protein [Function unknown]; Region: COG2860 1121353000412 UPF0126 domain; Region: UPF0126; pfam03458 1121353000413 UPF0126 domain; Region: UPF0126; pfam03458 1121353000414 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1121353000415 tetramerization interface [polypeptide binding]; other site 1121353000416 active site 1121353000417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 1121353000418 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1121353000419 Cna protein B-type domain; Region: Cna_B; pfam05738 1121353000420 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1121353000421 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1121353000422 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1121353000423 hypothetical protein; Provisional; Region: PRK10621 1121353000424 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1121353000425 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 1121353000426 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121353000427 ATP binding site [chemical binding]; other site 1121353000428 putative Mg++ binding site [ion binding]; other site 1121353000429 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121353000430 nucleotide binding region [chemical binding]; other site 1121353000431 Helicase associated domain (HA2); Region: HA2; pfam04408 1121353000432 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1121353000433 maltose O-acetyltransferase; Provisional; Region: PRK10092 1121353000434 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1121353000435 active site 1121353000436 substrate binding site [chemical binding]; other site 1121353000437 trimer interface [polypeptide binding]; other site 1121353000438 CoA binding site [chemical binding]; other site 1121353000439 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1121353000440 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1121353000441 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121353000442 RNA binding surface [nucleotide binding]; other site 1121353000443 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1121353000444 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1121353000445 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1121353000446 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1121353000447 DNA binding site [nucleotide binding] 1121353000448 active site 1121353000449 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1121353000450 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1121353000451 glycogen branching enzyme; Provisional; Region: PRK14705 1121353000452 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1121353000453 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1121353000454 active site 1121353000455 Zn binding site [ion binding]; other site 1121353000456 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1121353000457 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1121353000458 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1121353000459 active site 1121353000460 dimer interface [polypeptide binding]; other site 1121353000461 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1121353000462 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1121353000463 active site 1121353000464 FMN binding site [chemical binding]; other site 1121353000465 substrate binding site [chemical binding]; other site 1121353000466 3Fe-4S cluster binding site [ion binding]; other site 1121353000467 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1121353000468 domain interface; other site 1121353000469 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1121353000470 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121353000471 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1121353000472 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1121353000473 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1121353000474 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1121353000475 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1121353000476 classical (c) SDRs; Region: SDR_c; cd05233 1121353000477 NAD(P) binding site [chemical binding]; other site 1121353000478 active site 1121353000479 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1121353000480 FAD binding domain; Region: FAD_binding_4; pfam01565 1121353000481 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1121353000482 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1121353000483 Predicted membrane protein [Function unknown]; Region: COG2246 1121353000484 GtrA-like protein; Region: GtrA; pfam04138 1121353000485 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1121353000486 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121353000487 active site 1121353000488 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1121353000489 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1121353000490 Walker A/P-loop; other site 1121353000491 ATP binding site [chemical binding]; other site 1121353000492 Q-loop/lid; other site 1121353000493 ABC transporter signature motif; other site 1121353000494 Walker B; other site 1121353000495 D-loop; other site 1121353000496 H-loop/switch region; other site 1121353000497 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1121353000498 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1121353000499 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1121353000500 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1121353000501 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121353000502 catalytic residue [active] 1121353000503 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1121353000504 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1121353000505 NAD(P) binding site [chemical binding]; other site 1121353000506 Predicted membrane protein [Function unknown]; Region: COG1950 1121353000507 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1121353000508 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121353000509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353000510 homodimer interface [polypeptide binding]; other site 1121353000511 catalytic residue [active] 1121353000512 prephenate dehydrogenase; Validated; Region: PRK06545 1121353000513 prephenate dehydrogenase; Validated; Region: PRK08507 1121353000514 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1121353000515 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1121353000516 nucleoside/Zn binding site; other site 1121353000517 dimer interface [polypeptide binding]; other site 1121353000518 catalytic motif [active] 1121353000519 CsbD-like; Region: CsbD; pfam05532 1121353000520 MMPL family; Region: MMPL; pfam03176 1121353000521 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1121353000522 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1121353000523 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1121353000524 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1121353000525 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121353000526 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121353000527 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121353000528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353000529 Q-loop/lid; other site 1121353000530 ABC transporter signature motif; other site 1121353000531 Walker B; other site 1121353000532 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1121353000533 active site 1121353000534 HIGH motif; other site 1121353000535 nucleotide binding site [chemical binding]; other site 1121353000536 active site 1121353000537 KMSKS motif; other site 1121353000538 potential frameshift: common BLAST hit: gi|62389135|ref|YP_224537.1| 3,4-dioxygenase beta subunit 1121353000539 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1121353000540 pentamer interface [polypeptide binding]; other site 1121353000541 dodecaamer interface [polypeptide binding]; other site 1121353000542 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1121353000543 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121353000544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353000545 homodimer interface [polypeptide binding]; other site 1121353000546 catalytic residue [active] 1121353000547 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1121353000548 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1121353000549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121353000550 Walker A motif; other site 1121353000551 ATP binding site [chemical binding]; other site 1121353000552 Walker B motif; other site 1121353000553 arginine finger; other site 1121353000554 hypothetical protein; Validated; Region: PRK00153 1121353000555 recombination protein RecR; Reviewed; Region: recR; PRK00076 1121353000556 RecR protein; Region: RecR; pfam02132 1121353000557 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1121353000558 putative active site [active] 1121353000559 putative metal-binding site [ion binding]; other site 1121353000560 tetramer interface [polypeptide binding]; other site 1121353000561 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1121353000562 catalytic triad [active] 1121353000563 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1121353000564 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121353000565 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1121353000566 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 1121353000567 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1121353000568 active site 1121353000569 Cna protein B-type domain; Region: Cna_B; pfam05738 1121353000570 Cna protein B-type domain; Region: Cna_B; pfam05738 1121353000571 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1121353000572 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1121353000573 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1121353000574 active site 1121353000575 catalytic site [active] 1121353000576 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1121353000577 active site 1121353000578 catalytic site [active] 1121353000579 2-isopropylmalate synthase; Validated; Region: PRK03739 1121353000580 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1121353000581 active site 1121353000582 catalytic residues [active] 1121353000583 metal binding site [ion binding]; metal-binding site 1121353000584 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1121353000585 aspartate kinase; Reviewed; Region: PRK06635 1121353000586 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1121353000587 putative nucleotide binding site [chemical binding]; other site 1121353000588 putative catalytic residues [active] 1121353000589 putative Mg ion binding site [ion binding]; other site 1121353000590 putative aspartate binding site [chemical binding]; other site 1121353000591 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1121353000592 putative allosteric regulatory site; other site 1121353000593 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1121353000594 putative allosteric regulatory residue; other site 1121353000595 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1121353000596 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1121353000597 RNA polymerase sigma factor; Provisional; Region: PRK12535 1121353000598 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121353000599 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121353000600 DNA binding residues [nucleotide binding] 1121353000601 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1121353000602 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1121353000603 heme binding pocket [chemical binding]; other site 1121353000604 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121353000605 dimerization interface [polypeptide binding]; other site 1121353000606 putative DNA binding site [nucleotide binding]; other site 1121353000607 putative Zn2+ binding site [ion binding]; other site 1121353000608 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1121353000609 arsenical-resistance protein; Region: acr3; TIGR00832 1121353000610 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1121353000611 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1121353000612 active site 1121353000613 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1121353000614 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1121353000615 active site 1121353000616 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1121353000617 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 1121353000618 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 1121353000619 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1121353000620 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1121353000621 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 1121353000622 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 1121353000623 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1121353000624 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1121353000625 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1121353000626 Predicted membrane protein [Function unknown]; Region: COG1511 1121353000627 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121353000628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121353000629 active site 1121353000630 phosphorylation site [posttranslational modification] 1121353000631 intermolecular recognition site; other site 1121353000632 dimerization interface [polypeptide binding]; other site 1121353000633 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121353000634 DNA binding site [nucleotide binding] 1121353000635 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1121353000636 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121353000637 dimerization interface [polypeptide binding]; other site 1121353000638 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121353000639 dimer interface [polypeptide binding]; other site 1121353000640 phosphorylation site [posttranslational modification] 1121353000641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121353000642 ATP binding site [chemical binding]; other site 1121353000643 Mg2+ binding site [ion binding]; other site 1121353000644 G-X-G motif; other site 1121353000645 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1121353000646 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1121353000647 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1121353000648 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121353000649 putative active site [active] 1121353000650 putative metal binding site [ion binding]; other site 1121353000651 Yqey-like protein; Region: YqeY; pfam09424 1121353000652 Transglycosylase; Region: Transgly; pfam00912 1121353000653 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1121353000654 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1121353000655 Transcription factor WhiB; Region: Whib; pfam02467 1121353000656 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1121353000657 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1121353000658 homotrimer interaction site [polypeptide binding]; other site 1121353000659 putative active site [active] 1121353000660 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1121353000661 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1121353000662 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1121353000663 ligand binding site [chemical binding]; other site 1121353000664 flexible hinge region; other site 1121353000665 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1121353000666 putative switch regulator; other site 1121353000667 non-specific DNA interactions [nucleotide binding]; other site 1121353000668 DNA binding site [nucleotide binding] 1121353000669 sequence specific DNA binding site [nucleotide binding]; other site 1121353000670 putative cAMP binding site [chemical binding]; other site 1121353000671 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1121353000672 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1121353000673 minor groove reading motif; other site 1121353000674 helix-hairpin-helix signature motif; other site 1121353000675 substrate binding pocket [chemical binding]; other site 1121353000676 active site 1121353000677 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1121353000678 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1121353000679 catalytic residues [active] 1121353000680 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1121353000681 putative active site [active] 1121353000682 putative CoA binding site [chemical binding]; other site 1121353000683 nudix motif; other site 1121353000684 metal binding site [ion binding]; metal-binding site 1121353000685 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1121353000686 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1121353000687 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1121353000688 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1121353000689 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1121353000690 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1121353000691 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121353000692 motif II; other site 1121353000693 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1121353000694 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1121353000695 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1121353000696 ATP binding site [chemical binding]; other site 1121353000697 Walker A motif; other site 1121353000698 hexamer interface [polypeptide binding]; other site 1121353000699 Walker B motif; other site 1121353000700 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1121353000701 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1121353000702 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 1121353000703 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1121353000704 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121353000705 ATP binding site [chemical binding]; other site 1121353000706 putative Mg++ binding site [ion binding]; other site 1121353000707 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121353000708 nucleotide binding region [chemical binding]; other site 1121353000709 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1121353000710 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1121353000711 DNA-binding site [nucleotide binding]; DNA binding site 1121353000712 RNA-binding motif; other site 1121353000713 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1121353000714 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1121353000715 active site 1121353000716 interdomain interaction site; other site 1121353000717 putative metal-binding site [ion binding]; other site 1121353000718 nucleotide binding site [chemical binding]; other site 1121353000719 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1121353000720 domain I; other site 1121353000721 DNA binding groove [nucleotide binding] 1121353000722 phosphate binding site [ion binding]; other site 1121353000723 domain II; other site 1121353000724 domain III; other site 1121353000725 nucleotide binding site [chemical binding]; other site 1121353000726 catalytic site [active] 1121353000727 domain IV; other site 1121353000728 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1121353000729 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1121353000730 YhhN-like protein; Region: YhhN; pfam07947 1121353000731 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121353000732 dimerization interface [polypeptide binding]; other site 1121353000733 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1121353000734 cyclase homology domain; Region: CHD; cd07302 1121353000735 nucleotidyl binding site; other site 1121353000736 metal binding site [ion binding]; metal-binding site 1121353000737 dimer interface [polypeptide binding]; other site 1121353000738 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1121353000739 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121353000740 Walker A motif; other site 1121353000741 ATP binding site [chemical binding]; other site 1121353000742 Walker B motif; other site 1121353000743 arginine finger; other site 1121353000744 topology modulation protein; Reviewed; Region: PRK08118 1121353000745 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 1121353000746 active site 1121353000747 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1121353000748 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1121353000749 NAD binding site [chemical binding]; other site 1121353000750 catalytic Zn binding site [ion binding]; other site 1121353000751 substrate binding site [chemical binding]; other site 1121353000752 structural Zn binding site [ion binding]; other site 1121353000753 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121353000754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353000755 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121353000756 putative substrate translocation pore; other site 1121353000757 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1121353000758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121353000759 NAD(P) binding site [chemical binding]; other site 1121353000760 active site 1121353000761 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1121353000762 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1121353000763 Ligand binding site; other site 1121353000764 Putative Catalytic site; other site 1121353000765 DXD motif; other site 1121353000766 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 1121353000767 active site 1121353000768 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1121353000769 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1121353000770 Probable Catalytic site; other site 1121353000771 metal-binding site 1121353000772 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1121353000773 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1121353000774 putative active site [active] 1121353000775 putative metal binding site [ion binding]; other site 1121353000776 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1121353000777 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1121353000778 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1121353000779 Thioredoxin; Region: Thioredoxin_4; cl17273 1121353000780 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1121353000781 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1121353000782 NAD binding site [chemical binding]; other site 1121353000783 catalytic Zn binding site [ion binding]; other site 1121353000784 structural Zn binding site [ion binding]; other site 1121353000785 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1121353000786 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353000787 Walker A/P-loop; other site 1121353000788 ATP binding site [chemical binding]; other site 1121353000789 Q-loop/lid; other site 1121353000790 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1121353000791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353000792 Walker A/P-loop; other site 1121353000793 ATP binding site [chemical binding]; other site 1121353000794 Q-loop/lid; other site 1121353000795 ABC transporter signature motif; other site 1121353000796 Walker B; other site 1121353000797 D-loop; other site 1121353000798 H-loop/switch region; other site 1121353000799 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1121353000800 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1121353000801 proposed catalytic triad [active] 1121353000802 conserved cys residue [active] 1121353000803 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1121353000804 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1121353000805 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1121353000806 putative NAD(P) binding site [chemical binding]; other site 1121353000807 putative substrate binding site [chemical binding]; other site 1121353000808 catalytic Zn binding site [ion binding]; other site 1121353000809 structural Zn binding site [ion binding]; other site 1121353000810 dimer interface [polypeptide binding]; other site 1121353000811 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1121353000812 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1121353000813 metabolite-proton symporter; Region: 2A0106; TIGR00883 1121353000814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353000815 putative substrate translocation pore; other site 1121353000816 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1121353000817 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1121353000818 substrate binding site; other site 1121353000819 tetramer interface; other site 1121353000820 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1121353000821 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1121353000822 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1121353000823 NADP binding site [chemical binding]; other site 1121353000824 active site 1121353000825 putative substrate binding site [chemical binding]; other site 1121353000826 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1121353000827 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1121353000828 NAD binding site [chemical binding]; other site 1121353000829 substrate binding site [chemical binding]; other site 1121353000830 homodimer interface [polypeptide binding]; other site 1121353000831 active site 1121353000832 LabA_like proteins; Region: LabA_like; cd06167 1121353000833 putative metal binding site [ion binding]; other site 1121353000834 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1121353000835 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1121353000836 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1121353000837 siderophore binding site; other site 1121353000838 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1121353000839 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1121353000840 FAD binding pocket [chemical binding]; other site 1121353000841 FAD binding motif [chemical binding]; other site 1121353000842 phosphate binding motif [ion binding]; other site 1121353000843 NAD binding pocket [chemical binding]; other site 1121353000844 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1121353000845 Zn binding site [ion binding]; other site 1121353000846 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1121353000847 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1121353000848 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1121353000849 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1121353000850 Putative esterase; Region: Esterase; pfam00756 1121353000851 potential frameshift: common BLAST hit: gi|62389238|ref|YP_224640.1| prolyl endopeptidase 1121353000852 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 1121353000853 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1121353000854 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 1121353000855 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121353000856 motif II; other site 1121353000857 Putative esterase; Region: Esterase; pfam00756 1121353000858 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1121353000859 Chain length determinant protein; Region: Wzz; cl15801 1121353000860 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1121353000861 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121353000862 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1121353000863 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1121353000864 active site 1121353000865 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1121353000866 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1121353000867 NAD(P) binding site [chemical binding]; other site 1121353000868 homodimer interface [polypeptide binding]; other site 1121353000869 substrate binding site [chemical binding]; other site 1121353000870 active site 1121353000871 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1121353000872 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1121353000873 inhibitor-cofactor binding pocket; inhibition site 1121353000874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353000875 catalytic residue [active] 1121353000876 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1121353000877 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1121353000878 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1121353000879 putative trimer interface [polypeptide binding]; other site 1121353000880 putative CoA binding site [chemical binding]; other site 1121353000881 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1121353000882 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121353000883 putative ADP-binding pocket [chemical binding]; other site 1121353000884 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1121353000885 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121353000886 active site 1121353000887 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121353000888 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1121353000889 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1121353000890 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1121353000891 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1121353000892 colanic acid exporter; Provisional; Region: PRK10459 1121353000893 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1121353000894 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1121353000895 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1121353000896 putative active site [active] 1121353000897 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 1121353000898 FAD binding domain; Region: FAD_binding_4; pfam01565 1121353000899 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1121353000900 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1121353000901 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121353000902 active site 1121353000903 O-Antigen ligase; Region: Wzy_C; pfam04932 1121353000904 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1121353000905 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1121353000906 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121353000907 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1121353000908 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1121353000909 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1121353000910 active site 1121353000911 tetramer interface; other site 1121353000912 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1121353000913 putative deacylase active site [active] 1121353000914 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121353000915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121353000916 non-specific DNA binding site [nucleotide binding]; other site 1121353000917 salt bridge; other site 1121353000918 sequence-specific DNA binding site [nucleotide binding]; other site 1121353000919 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1121353000920 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1121353000921 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1121353000922 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1121353000923 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1121353000924 putative Iron-sulfur protein interface [polypeptide binding]; other site 1121353000925 proximal heme binding site [chemical binding]; other site 1121353000926 distal heme binding site [chemical binding]; other site 1121353000927 putative dimer interface [polypeptide binding]; other site 1121353000928 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1121353000929 L-aspartate oxidase; Provisional; Region: PRK06175 1121353000930 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1121353000931 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1121353000932 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1121353000933 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1121353000934 Predicted membrane protein [Function unknown]; Region: COG2733 1121353000935 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1121353000936 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1121353000937 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121353000938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353000939 putative substrate translocation pore; other site 1121353000940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353000941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353000942 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1121353000943 putative substrate translocation pore; other site 1121353000944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353000945 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1121353000946 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1121353000947 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1121353000948 putative active site [active] 1121353000949 putative substrate binding site [chemical binding]; other site 1121353000950 putative cosubstrate binding site; other site 1121353000951 catalytic site [active] 1121353000952 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1121353000953 intersubunit interface [polypeptide binding]; other site 1121353000954 active site 1121353000955 catalytic residue [active] 1121353000956 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1121353000957 putative homodimer interface [polypeptide binding]; other site 1121353000958 putative homotetramer interface [polypeptide binding]; other site 1121353000959 putative allosteric switch controlling residues; other site 1121353000960 putative metal binding site [ion binding]; other site 1121353000961 putative homodimer-homodimer interface [polypeptide binding]; other site 1121353000962 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1121353000963 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1121353000964 metal-binding site [ion binding] 1121353000965 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121353000966 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1121353000967 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1121353000968 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1121353000969 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1121353000970 FAD binding domain; Region: FAD_binding_4; pfam01565 1121353000971 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1121353000972 hypothetical protein; Provisional; Region: PRK07758 1121353000973 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1121353000974 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 1121353000975 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121353000976 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121353000977 acyl-activating enzyme (AAE) consensus motif; other site 1121353000978 AMP binding site [chemical binding]; other site 1121353000979 active site 1121353000980 CoA binding site [chemical binding]; other site 1121353000981 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1121353000982 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1121353000983 putative ADP-binding pocket [chemical binding]; other site 1121353000984 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121353000985 catalytic core [active] 1121353000986 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121353000987 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121353000988 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121353000989 dimer interface [polypeptide binding]; other site 1121353000990 phosphorylation site [posttranslational modification] 1121353000991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121353000992 ATP binding site [chemical binding]; other site 1121353000993 Mg2+ binding site [ion binding]; other site 1121353000994 G-X-G motif; other site 1121353000995 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121353000996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121353000997 active site 1121353000998 phosphorylation site [posttranslational modification] 1121353000999 intermolecular recognition site; other site 1121353001000 dimerization interface [polypeptide binding]; other site 1121353001001 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121353001002 DNA binding site [nucleotide binding] 1121353001003 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1121353001004 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121353001005 FtsX-like permease family; Region: FtsX; pfam02687 1121353001006 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121353001007 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1121353001008 FtsX-like permease family; Region: FtsX; pfam02687 1121353001009 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1121353001010 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1121353001011 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1121353001012 pyrroline-5-carboxylate reductase; Region: PLN02688 1121353001013 DNA binding domain, excisionase family; Region: excise; TIGR01764 1121353001014 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1121353001015 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121353001016 motif II; other site 1121353001017 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1121353001018 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1121353001019 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1121353001020 tRNA; other site 1121353001021 putative tRNA binding site [nucleotide binding]; other site 1121353001022 putative NADP binding site [chemical binding]; other site 1121353001023 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1121353001024 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1121353001025 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1121353001026 domain interfaces; other site 1121353001027 active site 1121353001028 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1121353001029 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1121353001030 conserved cys residue [active] 1121353001031 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1121353001032 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1121353001033 active site 1121353001034 trimer interface [polypeptide binding]; other site 1121353001035 dimer interface [polypeptide binding]; other site 1121353001036 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 1121353001037 L11 interface [polypeptide binding]; other site 1121353001038 putative EF-Tu interaction site [polypeptide binding]; other site 1121353001039 putative EF-G interaction site [polypeptide binding]; other site 1121353001040 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1121353001041 active site 1121353001042 homodimer interface [polypeptide binding]; other site 1121353001043 SAM binding site [chemical binding]; other site 1121353001044 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1121353001045 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1121353001046 active site 1121353001047 Domain of unknown function (DUF3806); Region: DUF3806; pfam12713 1121353001048 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1121353001049 dimer interface [polypeptide binding]; other site 1121353001050 active site 1121353001051 Schiff base residues; other site 1121353001052 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1121353001053 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121353001054 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1121353001055 substrate binding site [chemical binding]; other site 1121353001056 active site 1121353001057 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1121353001058 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1121353001059 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1121353001060 inhibitor-cofactor binding pocket; inhibition site 1121353001061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353001062 catalytic residue [active] 1121353001063 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121353001064 catalytic core [active] 1121353001065 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1121353001066 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1121353001067 catalytic residues [active] 1121353001068 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1121353001069 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1121353001070 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1121353001071 ResB-like family; Region: ResB; pfam05140 1121353001072 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1121353001073 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121353001074 dimerization interface [polypeptide binding]; other site 1121353001075 putative DNA binding site [nucleotide binding]; other site 1121353001076 putative Zn2+ binding site [ion binding]; other site 1121353001077 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1121353001078 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1121353001079 UbiA prenyltransferase family; Region: UbiA; pfam01040 1121353001080 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1121353001081 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121353001082 acyl-activating enzyme (AAE) consensus motif; other site 1121353001083 AMP binding site [chemical binding]; other site 1121353001084 active site 1121353001085 CoA binding site [chemical binding]; other site 1121353001086 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1121353001087 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1121353001088 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1121353001089 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1121353001090 substrate binding site [chemical binding]; other site 1121353001091 oxyanion hole (OAH) forming residues; other site 1121353001092 trimer interface [polypeptide binding]; other site 1121353001093 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1121353001094 aromatic arch; other site 1121353001095 DCoH dimer interaction site [polypeptide binding]; other site 1121353001096 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1121353001097 DCoH tetramer interaction site [polypeptide binding]; other site 1121353001098 substrate binding site [chemical binding]; other site 1121353001099 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 1121353001100 catalytic triad [active] 1121353001101 active site nucleophile [active] 1121353001102 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1121353001103 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1121353001104 active site 1121353001105 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1121353001106 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1121353001107 dimer interface [polypeptide binding]; other site 1121353001108 tetramer interface [polypeptide binding]; other site 1121353001109 PYR/PP interface [polypeptide binding]; other site 1121353001110 TPP binding site [chemical binding]; other site 1121353001111 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1121353001112 TPP-binding site; other site 1121353001113 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1121353001114 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121353001115 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1121353001116 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1121353001117 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1121353001118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121353001119 S-adenosylmethionine binding site [chemical binding]; other site 1121353001120 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1121353001121 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1121353001122 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1121353001123 substrate binding pocket [chemical binding]; other site 1121353001124 chain length determination region; other site 1121353001125 substrate-Mg2+ binding site; other site 1121353001126 catalytic residues [active] 1121353001127 aspartate-rich region 1; other site 1121353001128 active site lid residues [active] 1121353001129 aspartate-rich region 2; other site 1121353001130 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1121353001131 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1121353001132 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1121353001133 putative homodimer interface [polypeptide binding]; other site 1121353001134 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1121353001135 heterodimer interface [polypeptide binding]; other site 1121353001136 homodimer interface [polypeptide binding]; other site 1121353001137 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1121353001138 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1121353001139 23S rRNA interface [nucleotide binding]; other site 1121353001140 L7/L12 interface [polypeptide binding]; other site 1121353001141 putative thiostrepton binding site; other site 1121353001142 L25 interface [polypeptide binding]; other site 1121353001143 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1121353001144 mRNA/rRNA interface [nucleotide binding]; other site 1121353001145 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1121353001146 active site 1121353001147 substrate binding sites [chemical binding]; other site 1121353001148 Predicted membrane protein [Function unknown]; Region: COG2311 1121353001149 Integrase core domain; Region: rve; pfam00665 1121353001150 Integrase core domain; Region: rve_3; pfam13683 1121353001151 HTH-like domain; Region: HTH_21; pfam13276 1121353001152 Transposase; Region: HTH_Tnp_1; pfam01527 1121353001153 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1121353001154 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 1121353001155 FIC domain binding interface [polypeptide binding]; other site 1121353001156 Fic/DOC family; Region: Fic; cl00960 1121353001157 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1121353001158 Low affinity iron permease; Region: Iron_permease; cl12096 1121353001159 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1121353001160 Predicted membrane protein [Function unknown]; Region: COG4325 1121353001161 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1121353001162 PRC-barrel domain; Region: PRC; pfam05239 1121353001163 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 1121353001164 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1121353001165 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1121353001166 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1121353001167 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1121353001168 NAD binding site [chemical binding]; other site 1121353001169 catalytic Zn binding site [ion binding]; other site 1121353001170 structural Zn binding site [ion binding]; other site 1121353001171 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1121353001172 Hexameric tyrosine-coordinated heme protein (HTHP); Region: HTHP; pfam11534 1121353001173 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1121353001174 Ferredoxin [Energy production and conversion]; Region: COG1146 1121353001175 4Fe-4S binding domain; Region: Fer4; pfam00037 1121353001176 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1121353001177 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1121353001178 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1121353001179 putative NAD(P) binding site [chemical binding]; other site 1121353001180 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1121353001181 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1121353001182 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121353001183 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121353001184 motif II; other site 1121353001185 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1121353001186 metal-binding site [ion binding] 1121353001187 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1121353001188 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1121353001189 ligand binding site [chemical binding]; other site 1121353001190 flexible hinge region; other site 1121353001191 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1121353001192 Heavy-metal-associated domain; Region: HMA; pfam00403 1121353001193 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1121353001194 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1121353001195 NAD(P) binding site [chemical binding]; other site 1121353001196 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1121353001197 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1121353001198 Presynaptic Site I dimer interface [polypeptide binding]; other site 1121353001199 catalytic residues [active] 1121353001200 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1121353001201 Synaptic Flat tetramer interface [polypeptide binding]; other site 1121353001202 Synaptic Site I dimer interface [polypeptide binding]; other site 1121353001203 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1121353001204 DNA-binding interface [nucleotide binding]; DNA binding site 1121353001205 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1121353001206 Integrase core domain; Region: rve; pfam00665 1121353001207 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1121353001208 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1121353001209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 1121353001210 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1121353001211 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121353001212 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121353001213 motif I; other site 1121353001214 motif II; other site 1121353001215 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1121353001216 metal-binding site [ion binding] 1121353001217 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121353001218 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121353001219 dimerization interface [polypeptide binding]; other site 1121353001220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121353001221 dimer interface [polypeptide binding]; other site 1121353001222 phosphorylation site [posttranslational modification] 1121353001223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121353001224 ATP binding site [chemical binding]; other site 1121353001225 Mg2+ binding site [ion binding]; other site 1121353001226 G-X-G motif; other site 1121353001227 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121353001228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121353001229 active site 1121353001230 phosphorylation site [posttranslational modification] 1121353001231 intermolecular recognition site; other site 1121353001232 dimerization interface [polypeptide binding]; other site 1121353001233 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121353001234 DNA binding site [nucleotide binding] 1121353001235 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1121353001236 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1121353001237 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1121353001238 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1121353001239 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121353001240 dimerization interface [polypeptide binding]; other site 1121353001241 putative DNA binding site [nucleotide binding]; other site 1121353001242 putative Zn2+ binding site [ion binding]; other site 1121353001243 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 1121353001244 Cadmium resistance transporter; Region: Cad; pfam03596 1121353001245 RDD family; Region: RDD; pfam06271 1121353001246 Beta-lactamase; Region: Beta-lactamase; pfam00144 1121353001247 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1121353001248 short chain dehydrogenase; Provisional; Region: PRK08263 1121353001249 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1121353001250 NADP binding site [chemical binding]; other site 1121353001251 active site 1121353001252 steroid binding site; other site 1121353001253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121353001254 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1121353001255 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1121353001256 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1121353001257 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1121353001258 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1121353001259 inhibitor-cofactor binding pocket; inhibition site 1121353001260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353001261 catalytic residue [active] 1121353001262 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1121353001263 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1121353001264 tetramerization interface [polypeptide binding]; other site 1121353001265 NAD(P) binding site [chemical binding]; other site 1121353001266 catalytic residues [active] 1121353001267 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1121353001268 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1121353001269 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1121353001270 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121353001271 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1121353001272 23S rRNA interface [nucleotide binding]; other site 1121353001273 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1121353001274 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1121353001275 L11 interface [polypeptide binding]; other site 1121353001276 putative EF-Tu interaction site [polypeptide binding]; other site 1121353001277 putative EF-G interaction site [polypeptide binding]; other site 1121353001278 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1121353001279 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1121353001280 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1121353001281 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1121353001282 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1121353001283 RPB1 interaction site [polypeptide binding]; other site 1121353001284 RPB10 interaction site [polypeptide binding]; other site 1121353001285 RPB11 interaction site [polypeptide binding]; other site 1121353001286 RPB3 interaction site [polypeptide binding]; other site 1121353001287 RPB12 interaction site [polypeptide binding]; other site 1121353001288 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1121353001289 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1121353001290 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1121353001291 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1121353001292 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1121353001293 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1121353001294 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1121353001295 G-loop; other site 1121353001296 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1121353001297 DNA binding site [nucleotide binding] 1121353001298 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1121353001299 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121353001300 salt bridge; other site 1121353001301 non-specific DNA binding site [nucleotide binding]; other site 1121353001302 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121353001303 sequence-specific DNA binding site [nucleotide binding]; other site 1121353001304 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1121353001305 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1121353001306 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1121353001307 S17 interaction site [polypeptide binding]; other site 1121353001308 S8 interaction site; other site 1121353001309 16S rRNA interaction site [nucleotide binding]; other site 1121353001310 streptomycin interaction site [chemical binding]; other site 1121353001311 23S rRNA interaction site [nucleotide binding]; other site 1121353001312 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1121353001313 30S ribosomal protein S7; Validated; Region: PRK05302 1121353001314 elongation factor G; Reviewed; Region: PRK00007 1121353001315 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1121353001316 G1 box; other site 1121353001317 putative GEF interaction site [polypeptide binding]; other site 1121353001318 GTP/Mg2+ binding site [chemical binding]; other site 1121353001319 Switch I region; other site 1121353001320 G2 box; other site 1121353001321 G3 box; other site 1121353001322 Switch II region; other site 1121353001323 G4 box; other site 1121353001324 G5 box; other site 1121353001325 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1121353001326 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1121353001327 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1121353001328 elongation factor Tu; Reviewed; Region: PRK00049 1121353001329 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1121353001330 G1 box; other site 1121353001331 GEF interaction site [polypeptide binding]; other site 1121353001332 GTP/Mg2+ binding site [chemical binding]; other site 1121353001333 Switch I region; other site 1121353001334 G2 box; other site 1121353001335 G3 box; other site 1121353001336 Switch II region; other site 1121353001337 G4 box; other site 1121353001338 G5 box; other site 1121353001339 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1121353001340 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1121353001341 Antibiotic Binding Site [chemical binding]; other site 1121353001342 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1121353001343 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1121353001344 Walker A/P-loop; other site 1121353001345 ATP binding site [chemical binding]; other site 1121353001346 Q-loop/lid; other site 1121353001347 ABC transporter signature motif; other site 1121353001348 Walker B; other site 1121353001349 D-loop; other site 1121353001350 H-loop/switch region; other site 1121353001351 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1121353001352 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121353001353 ABC-ATPase subunit interface; other site 1121353001354 dimer interface [polypeptide binding]; other site 1121353001355 putative PBP binding regions; other site 1121353001356 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1121353001357 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121353001358 ABC-ATPase subunit interface; other site 1121353001359 dimer interface [polypeptide binding]; other site 1121353001360 putative PBP binding regions; other site 1121353001361 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1121353001362 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1121353001363 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1121353001364 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1121353001365 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1121353001366 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1121353001367 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1121353001368 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1121353001369 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1121353001370 putative translocon binding site; other site 1121353001371 protein-rRNA interface [nucleotide binding]; other site 1121353001372 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1121353001373 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1121353001374 G-X-X-G motif; other site 1121353001375 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1121353001376 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1121353001377 23S rRNA interface [nucleotide binding]; other site 1121353001378 5S rRNA interface [nucleotide binding]; other site 1121353001379 putative antibiotic binding site [chemical binding]; other site 1121353001380 L25 interface [polypeptide binding]; other site 1121353001381 L27 interface [polypeptide binding]; other site 1121353001382 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1121353001383 putative translocon interaction site; other site 1121353001384 23S rRNA interface [nucleotide binding]; other site 1121353001385 signal recognition particle (SRP54) interaction site; other site 1121353001386 L23 interface [polypeptide binding]; other site 1121353001387 trigger factor interaction site; other site 1121353001388 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1121353001389 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1121353001390 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1121353001391 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1121353001392 RNA binding site [nucleotide binding]; other site 1121353001393 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1121353001394 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1121353001395 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1121353001396 Cna protein B-type domain; Region: Cna_B; pfam05738 1121353001397 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121353001398 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1121353001399 active site 1121353001400 catalytic tetrad [active] 1121353001401 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 1121353001402 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1121353001403 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1121353001404 Walker A/P-loop; other site 1121353001405 ATP binding site [chemical binding]; other site 1121353001406 Q-loop/lid; other site 1121353001407 ABC transporter signature motif; other site 1121353001408 Walker B; other site 1121353001409 D-loop; other site 1121353001410 H-loop/switch region; other site 1121353001411 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1121353001412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353001413 Walker A/P-loop; other site 1121353001414 ATP binding site [chemical binding]; other site 1121353001415 Q-loop/lid; other site 1121353001416 ABC transporter signature motif; other site 1121353001417 Walker B; other site 1121353001418 D-loop; other site 1121353001419 H-loop/switch region; other site 1121353001420 Predicted acetyltransferase [General function prediction only]; Region: COG3981 1121353001421 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1121353001422 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1121353001423 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1121353001424 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1121353001425 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1121353001426 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1121353001427 5S rRNA interface [nucleotide binding]; other site 1121353001428 L27 interface [polypeptide binding]; other site 1121353001429 23S rRNA interface [nucleotide binding]; other site 1121353001430 L5 interface [polypeptide binding]; other site 1121353001431 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1121353001432 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1121353001433 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1121353001434 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1121353001435 23S rRNA binding site [nucleotide binding]; other site 1121353001436 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1121353001437 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1121353001438 SecY translocase; Region: SecY; pfam00344 1121353001439 adenylate kinase; Reviewed; Region: adk; PRK00279 1121353001440 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1121353001441 AMP-binding site [chemical binding]; other site 1121353001442 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1121353001443 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1121353001444 active site 1121353001445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1121353001446 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1121353001447 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1121353001448 rRNA binding site [nucleotide binding]; other site 1121353001449 predicted 30S ribosome binding site; other site 1121353001450 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1121353001451 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1121353001452 30S ribosomal protein S11; Validated; Region: PRK05309 1121353001453 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1121353001454 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1121353001455 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121353001456 RNA binding surface [nucleotide binding]; other site 1121353001457 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1121353001458 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1121353001459 alphaNTD - beta interaction site [polypeptide binding]; other site 1121353001460 alphaNTD homodimer interface [polypeptide binding]; other site 1121353001461 alphaNTD - beta' interaction site [polypeptide binding]; other site 1121353001462 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1121353001463 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1121353001464 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1121353001465 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1121353001466 dimerization interface 3.5A [polypeptide binding]; other site 1121353001467 active site 1121353001468 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 1121353001469 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1121353001470 FAD binding domain; Region: FAD_binding_4; pfam01565 1121353001471 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1121353001472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121353001473 S-adenosylmethionine binding site [chemical binding]; other site 1121353001474 TIGR02611 family protein; Region: TIGR02611 1121353001475 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1121353001476 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1121353001477 active site 1121353001478 catalytic residues [active] 1121353001479 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1121353001480 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1121353001481 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1121353001482 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1121353001483 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1121353001484 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1121353001485 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1121353001486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1121353001487 Integrase core domain; Region: rve; pfam00665 1121353001488 Integrase core domain; Region: rve_3; pfam13683 1121353001489 HTH-like domain; Region: HTH_21; pfam13276 1121353001490 Transposase; Region: HTH_Tnp_1; pfam01527 1121353001491 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1121353001492 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1121353001493 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1121353001494 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1121353001495 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1121353001496 23S rRNA interface [nucleotide binding]; other site 1121353001497 L3 interface [polypeptide binding]; other site 1121353001498 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1121353001499 HTH-like domain; Region: HTH_21; pfam13276 1121353001500 Integrase core domain; Region: rve; pfam00665 1121353001501 HicB family; Region: HicB; pfam05534 1121353001502 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1121353001503 DNA methylase; Region: N6_N4_Mtase; pfam01555 1121353001504 D-lactate dehydrogenase; Provisional; Region: PRK11183 1121353001505 FAD binding domain; Region: FAD_binding_4; pfam01565 1121353001506 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1121353001507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1121353001508 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1121353001509 HTH-like domain; Region: HTH_21; pfam13276 1121353001510 Integrase core domain; Region: rve; pfam00665 1121353001511 HTH-like domain; Region: HTH_21; pfam13276 1121353001512 Integrase core domain; Region: rve; pfam00665 1121353001513 Integrase core domain; Region: rve_3; pfam13683 1121353001514 potential frameshift: common BLAST hit: gi|227833325|ref|YP_002835032.1| transposase 1121353001515 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1121353001516 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1121353001517 active site 1121353001518 substrate binding site [chemical binding]; other site 1121353001519 metal binding site [ion binding]; metal-binding site 1121353001520 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1121353001521 alanine racemase; Reviewed; Region: alr; PRK00053 1121353001522 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1121353001523 active site 1121353001524 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121353001525 dimer interface [polypeptide binding]; other site 1121353001526 substrate binding site [chemical binding]; other site 1121353001527 catalytic residues [active] 1121353001528 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1121353001529 Predicted permease [General function prediction only]; Region: COG2985 1121353001530 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1121353001531 TrkA-C domain; Region: TrkA_C; pfam02080 1121353001532 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1121353001533 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1121353001534 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1121353001535 Glycoprotease family; Region: Peptidase_M22; pfam00814 1121353001536 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1121353001537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121353001538 Coenzyme A binding pocket [chemical binding]; other site 1121353001539 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1121353001540 UGMP family protein; Validated; Region: PRK09604 1121353001541 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1121353001542 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1121353001543 putative substrate binding site [chemical binding]; other site 1121353001544 putative ATP binding site [chemical binding]; other site 1121353001545 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1121353001546 oligomerisation interface [polypeptide binding]; other site 1121353001547 mobile loop; other site 1121353001548 roof hairpin; other site 1121353001549 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1121353001550 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1121353001551 ring oligomerisation interface [polypeptide binding]; other site 1121353001552 ATP/Mg binding site [chemical binding]; other site 1121353001553 stacking interactions; other site 1121353001554 hinge regions; other site 1121353001555 Transcription factor WhiB; Region: Whib; pfam02467 1121353001556 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1121353001557 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121353001558 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121353001559 DNA binding residues [nucleotide binding] 1121353001560 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1121353001561 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1121353001562 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1121353001563 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1121353001564 active site 1121353001565 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1121353001566 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1121353001567 phosphate binding site [ion binding]; other site 1121353001568 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1121353001569 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1121353001570 GMP synthase; Reviewed; Region: guaA; PRK00074 1121353001571 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1121353001572 AMP/PPi binding site [chemical binding]; other site 1121353001573 candidate oxyanion hole; other site 1121353001574 catalytic triad [active] 1121353001575 potential glutamine specificity residues [chemical binding]; other site 1121353001576 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1121353001577 ATP Binding subdomain [chemical binding]; other site 1121353001578 Ligand Binding sites [chemical binding]; other site 1121353001579 Dimerization subdomain; other site 1121353001580 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1121353001581 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1121353001582 PspC domain; Region: PspC; pfam04024 1121353001583 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1121353001584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121353001585 ATP binding site [chemical binding]; other site 1121353001586 Mg2+ binding site [ion binding]; other site 1121353001587 G-X-G motif; other site 1121353001588 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121353001589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121353001590 active site 1121353001591 phosphorylation site [posttranslational modification] 1121353001592 intermolecular recognition site; other site 1121353001593 dimerization interface [polypeptide binding]; other site 1121353001594 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121353001595 dimerization interface [polypeptide binding]; other site 1121353001596 DNA binding residues [nucleotide binding] 1121353001597 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 1121353001598 DNA Polymerase Y-family; Region: PolY_like; cd03468 1121353001599 active site 1121353001600 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1121353001601 DNA binding site [nucleotide binding] 1121353001602 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 1121353001603 putative dimer interface [polypeptide binding]; other site 1121353001604 putative [2Fe-2S] cluster binding site [ion binding]; other site 1121353001605 potential frameshift: common BLAST hit: gi|62389523|ref|YP_224925.1| ABC transporter inner membrane protein 1121353001606 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121353001607 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121353001608 Walker A/P-loop; other site 1121353001609 ATP binding site [chemical binding]; other site 1121353001610 Q-loop/lid; other site 1121353001611 ABC transporter signature motif; other site 1121353001612 Walker B; other site 1121353001613 D-loop; other site 1121353001614 H-loop/switch region; other site 1121353001615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353001616 dimer interface [polypeptide binding]; other site 1121353001617 conserved gate region; other site 1121353001618 putative PBP binding loops; other site 1121353001619 ABC-ATPase subunit interface; other site 1121353001620 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1121353001621 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1121353001622 Walker A/P-loop; other site 1121353001623 ATP binding site [chemical binding]; other site 1121353001624 Q-loop/lid; other site 1121353001625 ABC transporter signature motif; other site 1121353001626 Walker B; other site 1121353001627 D-loop; other site 1121353001628 H-loop/switch region; other site 1121353001629 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1121353001630 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1121353001631 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1121353001632 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1121353001633 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1121353001634 active site 1121353001635 PHP Thumb interface [polypeptide binding]; other site 1121353001636 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1121353001637 generic binding surface II; other site 1121353001638 generic binding surface I; other site 1121353001639 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1121353001640 Predicted membrane protein [Function unknown]; Region: COG3428 1121353001641 Bacterial PH domain; Region: DUF304; pfam03703 1121353001642 Bacterial PH domain; Region: DUF304; pfam03703 1121353001643 Bacterial PH domain; Region: DUF304; pfam03703 1121353001644 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1121353001645 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1121353001646 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1121353001647 FeoA domain; Region: FeoA; pfam04023 1121353001648 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1121353001649 NAD-dependent deacetylase; Provisional; Region: PRK00481 1121353001650 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1121353001651 NAD+ binding site [chemical binding]; other site 1121353001652 substrate binding site [chemical binding]; other site 1121353001653 Zn binding site [ion binding]; other site 1121353001654 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1121353001655 nucleoside/Zn binding site; other site 1121353001656 catalytic motif [active] 1121353001657 dimer interface [polypeptide binding]; other site 1121353001658 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1121353001659 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1121353001660 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1121353001661 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1121353001662 homodimer interface [polypeptide binding]; other site 1121353001663 NADP binding site [chemical binding]; other site 1121353001664 substrate binding site [chemical binding]; other site 1121353001665 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1121353001666 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 1121353001667 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1121353001668 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1121353001669 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 1121353001670 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1121353001671 homodimer interface [polypeptide binding]; other site 1121353001672 substrate-cofactor binding pocket; other site 1121353001673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353001674 catalytic residue [active] 1121353001675 carbon starvation protein A; Provisional; Region: PRK15015 1121353001676 Carbon starvation protein CstA; Region: CstA; pfam02554 1121353001677 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1121353001678 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1121353001679 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1121353001680 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1121353001681 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1121353001682 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1121353001683 FAD binding pocket [chemical binding]; other site 1121353001684 FAD binding motif [chemical binding]; other site 1121353001685 phosphate binding motif [ion binding]; other site 1121353001686 NAD binding pocket [chemical binding]; other site 1121353001687 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1121353001688 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1121353001689 Walker A/P-loop; other site 1121353001690 ATP binding site [chemical binding]; other site 1121353001691 Q-loop/lid; other site 1121353001692 ABC transporter signature motif; other site 1121353001693 Walker B; other site 1121353001694 D-loop; other site 1121353001695 H-loop/switch region; other site 1121353001696 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1121353001697 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121353001698 ABC-ATPase subunit interface; other site 1121353001699 dimer interface [polypeptide binding]; other site 1121353001700 putative PBP binding regions; other site 1121353001701 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1121353001702 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121353001703 ABC-ATPase subunit interface; other site 1121353001704 dimer interface [polypeptide binding]; other site 1121353001705 putative PBP binding regions; other site 1121353001706 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1121353001707 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1121353001708 siderophore binding site; other site 1121353001709 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1121353001710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353001711 putative substrate translocation pore; other site 1121353001712 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1121353001713 putative active site [active] 1121353001714 putative catalytic site [active] 1121353001715 putative DNA binding site [nucleotide binding]; other site 1121353001716 putative phosphate binding site [ion binding]; other site 1121353001717 metal binding site A [ion binding]; metal-binding site 1121353001718 putative AP binding site [nucleotide binding]; other site 1121353001719 putative metal binding site B [ion binding]; other site 1121353001720 Predicted membrane protein [Function unknown]; Region: COG2860 1121353001721 UPF0126 domain; Region: UPF0126; pfam03458 1121353001722 UPF0126 domain; Region: UPF0126; pfam03458 1121353001723 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1121353001724 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1121353001725 active site 1121353001726 HIGH motif; other site 1121353001727 dimer interface [polypeptide binding]; other site 1121353001728 KMSKS motif; other site 1121353001729 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1121353001730 RDD family; Region: RDD; pfam06271 1121353001731 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1121353001732 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1121353001733 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1121353001734 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1121353001735 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1121353001736 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1121353001737 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1121353001738 NlpC/P60 family; Region: NLPC_P60; pfam00877 1121353001739 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121353001740 active site 1121353001741 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121353001742 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121353001743 non-specific DNA binding site [nucleotide binding]; other site 1121353001744 salt bridge; other site 1121353001745 sequence-specific DNA binding site [nucleotide binding]; other site 1121353001746 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1121353001747 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1121353001748 active site 1121353001749 substrate binding site [chemical binding]; other site 1121353001750 metal binding site [ion binding]; metal-binding site 1121353001751 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1121353001752 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1121353001753 metal binding site [ion binding]; metal-binding site 1121353001754 putative dimer interface [polypeptide binding]; other site 1121353001755 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1121353001756 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121353001757 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121353001758 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1121353001759 pyruvate carboxylase; Reviewed; Region: PRK12999 1121353001760 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121353001761 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121353001762 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1121353001763 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1121353001764 active site 1121353001765 catalytic residues [active] 1121353001766 metal binding site [ion binding]; metal-binding site 1121353001767 homodimer binding site [polypeptide binding]; other site 1121353001768 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1121353001769 carboxyltransferase (CT) interaction site; other site 1121353001770 biotinylation site [posttranslational modification]; other site 1121353001771 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1121353001772 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1121353001773 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1121353001774 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1121353001775 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1121353001776 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1121353001777 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121353001778 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1121353001779 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1121353001780 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1121353001781 carboxyltransferase (CT) interaction site; other site 1121353001782 biotinylation site [posttranslational modification]; other site 1121353001783 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1121353001784 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1121353001785 active site residue [active] 1121353001786 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1121353001787 active site residue [active] 1121353001788 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1121353001789 Maf-like protein; Region: Maf; pfam02545 1121353001790 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1121353001791 active site 1121353001792 dimer interface [polypeptide binding]; other site 1121353001793 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1121353001794 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1121353001795 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1121353001796 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1121353001797 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1121353001798 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1121353001799 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1121353001800 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1121353001801 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1121353001802 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1121353001803 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1121353001804 ATP-grasp domain; Region: ATP-grasp; pfam02222 1121353001805 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1121353001806 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1121353001807 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1121353001808 putative active site [active] 1121353001809 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1121353001810 RibD C-terminal domain; Region: RibD_C; cl17279 1121353001811 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121353001812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353001813 dimer interface [polypeptide binding]; other site 1121353001814 conserved gate region; other site 1121353001815 putative PBP binding loops; other site 1121353001816 ABC-ATPase subunit interface; other site 1121353001817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353001818 dimer interface [polypeptide binding]; other site 1121353001819 conserved gate region; other site 1121353001820 putative PBP binding loops; other site 1121353001821 ABC-ATPase subunit interface; other site 1121353001822 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1121353001823 hydrophobic ligand binding site; other site 1121353001824 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121353001825 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1121353001826 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1121353001827 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1121353001828 Walker A/P-loop; other site 1121353001829 ATP binding site [chemical binding]; other site 1121353001830 Q-loop/lid; other site 1121353001831 ABC transporter signature motif; other site 1121353001832 Walker B; other site 1121353001833 D-loop; other site 1121353001834 H-loop/switch region; other site 1121353001835 TOBE domain; Region: TOBE_2; pfam08402 1121353001836 TIGR03089 family protein; Region: TIGR03089 1121353001837 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1121353001838 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1121353001839 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1121353001840 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1121353001841 Probable Catalytic site; other site 1121353001842 metal-binding site 1121353001843 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1121353001844 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1121353001845 active site 1121353001846 Substrate binding site; other site 1121353001847 Mg++ binding site; other site 1121353001848 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121353001849 Transcription factor WhiB; Region: Whib; pfam02467 1121353001850 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1121353001851 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1121353001852 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1121353001853 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1121353001854 active site 1121353001855 substrate binding site [chemical binding]; other site 1121353001856 metal binding site [ion binding]; metal-binding site 1121353001857 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1121353001858 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1121353001859 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1121353001860 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 1121353001861 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1121353001862 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1121353001863 homotetramer interface [polypeptide binding]; other site 1121353001864 ligand binding site [chemical binding]; other site 1121353001865 catalytic site [active] 1121353001866 NAD binding site [chemical binding]; other site 1121353001867 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1121353001868 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1121353001869 TMP-binding site; other site 1121353001870 ATP-binding site [chemical binding]; other site 1121353001871 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121353001872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121353001873 active site 1121353001874 phosphorylation site [posttranslational modification] 1121353001875 intermolecular recognition site; other site 1121353001876 dimerization interface [polypeptide binding]; other site 1121353001877 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121353001878 DNA binding site [nucleotide binding] 1121353001879 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121353001880 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121353001881 dimerization interface [polypeptide binding]; other site 1121353001882 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121353001883 dimer interface [polypeptide binding]; other site 1121353001884 phosphorylation site [posttranslational modification] 1121353001885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121353001886 ATP binding site [chemical binding]; other site 1121353001887 Mg2+ binding site [ion binding]; other site 1121353001888 G-X-G motif; other site 1121353001889 lipoprotein LpqB; Provisional; Region: PRK13616 1121353001890 Sporulation and spore germination; Region: Germane; pfam10646 1121353001891 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1121353001892 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121353001893 active site 1121353001894 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1121353001895 30S subunit binding site; other site 1121353001896 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1121353001897 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1121353001898 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1121353001899 nucleotide binding region [chemical binding]; other site 1121353001900 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1121353001901 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1121353001902 Predicted GTPases [General function prediction only]; Region: COG1162 1121353001903 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1121353001904 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1121353001905 GTP/Mg2+ binding site [chemical binding]; other site 1121353001906 G4 box; other site 1121353001907 G5 box; other site 1121353001908 G1 box; other site 1121353001909 Switch I region; other site 1121353001910 G2 box; other site 1121353001911 G3 box; other site 1121353001912 Switch II region; other site 1121353001913 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1121353001914 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1121353001915 hinge; other site 1121353001916 active site 1121353001917 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1121353001918 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1121353001919 active site 1121353001920 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1121353001921 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121353001922 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121353001923 DNA binding residues [nucleotide binding] 1121353001924 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1121353001925 Transcription factor WhiB; Region: Whib; pfam02467 1121353001926 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 1121353001927 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1121353001928 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1121353001929 ATP binding site [chemical binding]; other site 1121353001930 Mg++ binding site [ion binding]; other site 1121353001931 motif III; other site 1121353001932 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121353001933 nucleotide binding region [chemical binding]; other site 1121353001934 ATP-binding site [chemical binding]; other site 1121353001935 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1121353001936 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1121353001937 TIGR02569 family protein; Region: TIGR02569_actnb 1121353001938 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1121353001939 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1121353001940 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1121353001941 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1121353001942 Ion channel; Region: Ion_trans_2; pfam07885 1121353001943 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1121353001944 TrkA-N domain; Region: TrkA_N; pfam02254 1121353001945 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1121353001946 putative NADH binding site [chemical binding]; other site 1121353001947 putative active site [active] 1121353001948 nudix motif; other site 1121353001949 putative metal binding site [ion binding]; other site 1121353001950 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1121353001951 Part of AAA domain; Region: AAA_19; pfam13245 1121353001952 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1121353001953 Family description; Region: UvrD_C_2; pfam13538 1121353001954 HRDC domain; Region: HRDC; pfam00570 1121353001955 Protein of unknown function DUF45; Region: DUF45; cl00636 1121353001956 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1121353001957 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1121353001958 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1121353001959 PDZ domain; Region: PDZ_2; pfam13180 1121353001960 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1121353001961 hypothetical protein; Validated; Region: PRK00068 1121353001962 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1121353001963 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1121353001964 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121353001965 DNA-binding site [nucleotide binding]; DNA binding site 1121353001966 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121353001967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353001968 homodimer interface [polypeptide binding]; other site 1121353001969 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1121353001970 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1121353001971 active site 1121353001972 multimer interface [polypeptide binding]; other site 1121353001973 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1121353001974 predicted active site [active] 1121353001975 catalytic triad [active] 1121353001976 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1121353001977 substrate binding sites [chemical binding]; other site 1121353001978 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1121353001979 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1121353001980 active site 1121353001981 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1121353001982 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1121353001983 active site 1121353001984 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1121353001985 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1121353001986 RF-1 domain; Region: RF-1; pfam00472 1121353001987 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1121353001988 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353001989 Walker A/P-loop; other site 1121353001990 ATP binding site [chemical binding]; other site 1121353001991 Q-loop/lid; other site 1121353001992 ABC transporter signature motif; other site 1121353001993 Walker B; other site 1121353001994 D-loop; other site 1121353001995 H-loop/switch region; other site 1121353001996 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1121353001997 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1121353001998 FtsX-like permease family; Region: FtsX; pfam02687 1121353001999 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1121353002000 SmpB-tmRNA interface; other site 1121353002001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1121353002002 sequence-specific DNA binding site [nucleotide binding]; other site 1121353002003 salt bridge; other site 1121353002004 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121353002005 Coenzyme A binding pocket [chemical binding]; other site 1121353002006 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1121353002007 Helix-turn-helix domain; Region: HTH_36; pfam13730 1121353002008 Transcription factor WhiB; Region: Whib; pfam02467 1121353002009 Domain of unknown function (DUF4313); Region: DUF4313; pfam14190 1121353002010 Cutinase; Region: Cutinase; pfam01083 1121353002011 AAA-like domain; Region: AAA_10; pfam12846 1121353002012 Domain of unknown function DUF87; Region: DUF87; pfam01935 1121353002013 Transposase; Region: HTH_Tnp_1; cl17663 1121353002014 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1121353002015 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121353002016 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1121353002017 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1121353002018 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1121353002019 catalytic residue [active] 1121353002020 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121353002021 Walker A motif; other site 1121353002022 ATP binding site [chemical binding]; other site 1121353002023 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1121353002024 Walker B motif; other site 1121353002025 Trypsin; Region: Trypsin; pfam00089 1121353002026 active site 1121353002027 substrate binding sites [chemical binding]; other site 1121353002028 TrwC relaxase; Region: TrwC; pfam08751 1121353002029 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1121353002030 AAA domain; Region: AAA_30; pfam13604 1121353002031 Family description; Region: UvrD_C_2; pfam13538 1121353002032 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1121353002033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121353002034 S-adenosylmethionine binding site [chemical binding]; other site 1121353002035 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1121353002036 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1121353002037 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1121353002038 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1121353002039 ATP-binding site [chemical binding]; other site 1121353002040 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1121353002041 Homeodomain-like domain; Region: HTH_23; pfam13384 1121353002042 Winged helix-turn helix; Region: HTH_29; pfam13551 1121353002043 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1121353002044 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1121353002045 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1121353002046 LGFP repeat; Region: LGFP; pfam08310 1121353002047 LGFP repeat; Region: LGFP; pfam08310 1121353002048 LGFP repeat; Region: LGFP; pfam08310 1121353002049 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1121353002050 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1121353002051 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1121353002052 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1121353002053 dimer interface [polypeptide binding]; other site 1121353002054 ssDNA binding site [nucleotide binding]; other site 1121353002055 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1121353002056 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1121353002057 LGFP repeat; Region: LGFP; pfam08310 1121353002058 LGFP repeat; Region: LGFP; pfam08310 1121353002059 Homeodomain-like domain; Region: HTH_23; cl17451 1121353002060 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1121353002061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121353002062 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1121353002063 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 1121353002064 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1121353002065 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121353002066 P-loop; other site 1121353002067 Magnesium ion binding site [ion binding]; other site 1121353002068 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1121353002069 active site 1121353002070 catalytic residues [active] 1121353002071 DNA binding site [nucleotide binding] 1121353002072 Int/Topo IB signature motif; other site 1121353002073 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1121353002074 putative active site [active] 1121353002075 redox center [active] 1121353002076 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1121353002077 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1121353002078 intersubunit interface [polypeptide binding]; other site 1121353002079 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1121353002080 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121353002081 ABC-ATPase subunit interface; other site 1121353002082 dimer interface [polypeptide binding]; other site 1121353002083 putative PBP binding regions; other site 1121353002084 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121353002085 ABC-ATPase subunit interface; other site 1121353002086 dimer interface [polypeptide binding]; other site 1121353002087 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1121353002088 putative PBP binding regions; other site 1121353002089 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1121353002090 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1121353002091 Walker A/P-loop; other site 1121353002092 ATP binding site [chemical binding]; other site 1121353002093 Q-loop/lid; other site 1121353002094 ABC transporter signature motif; other site 1121353002095 Walker B; other site 1121353002096 D-loop; other site 1121353002097 H-loop/switch region; other site 1121353002098 aminotransferase; Validated; Region: PRK07777 1121353002099 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121353002100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353002101 homodimer interface [polypeptide binding]; other site 1121353002102 catalytic residue [active] 1121353002103 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 1121353002104 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1121353002105 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1121353002106 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121353002107 ATP binding site [chemical binding]; other site 1121353002108 putative Mg++ binding site [ion binding]; other site 1121353002109 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121353002110 nucleotide binding region [chemical binding]; other site 1121353002111 ATP-binding site [chemical binding]; other site 1121353002112 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1121353002113 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1121353002114 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 1121353002115 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1121353002116 DNA-binding site [nucleotide binding]; DNA binding site 1121353002117 RNA-binding motif; other site 1121353002118 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1121353002119 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1121353002120 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1121353002121 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1121353002122 substrate-cofactor binding pocket; other site 1121353002123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353002124 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1121353002125 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1121353002126 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1121353002127 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1121353002128 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1121353002129 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 1121353002130 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121353002131 catalytic residue [active] 1121353002132 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1121353002133 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1121353002134 dimer interface [polypeptide binding]; other site 1121353002135 active site 1121353002136 citrylCoA binding site [chemical binding]; other site 1121353002137 NADH binding [chemical binding]; other site 1121353002138 cationic pore residues; other site 1121353002139 oxalacetate/citrate binding site [chemical binding]; other site 1121353002140 coenzyme A binding site [chemical binding]; other site 1121353002141 catalytic triad [active] 1121353002142 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1121353002143 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121353002144 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1121353002145 active site 1121353002146 catalytic tetrad [active] 1121353002147 Protein of unknown function, DUF485; Region: DUF485; cl01231 1121353002148 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1121353002149 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1121353002150 Na binding site [ion binding]; other site 1121353002151 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1121353002152 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1121353002153 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1121353002154 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1121353002155 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1121353002156 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1121353002157 phosphate binding site [ion binding]; other site 1121353002158 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1121353002159 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1121353002160 active site 2 [active] 1121353002161 active site 1 [active] 1121353002162 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1121353002163 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1121353002164 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1121353002165 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1121353002166 putative NAD(P) binding site [chemical binding]; other site 1121353002167 active site 1121353002168 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1121353002169 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1121353002170 active site 1121353002171 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1121353002172 catalytic residues [active] 1121353002173 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1121353002174 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1121353002175 folate binding site [chemical binding]; other site 1121353002176 NADP+ binding site [chemical binding]; other site 1121353002177 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1121353002178 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1121353002179 dimerization interface [polypeptide binding]; other site 1121353002180 active site 1121353002181 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1121353002182 active site 1121353002183 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121353002184 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1121353002185 ATP binding site [chemical binding]; other site 1121353002186 putative Mg++ binding site [ion binding]; other site 1121353002187 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121353002188 nucleotide binding region [chemical binding]; other site 1121353002189 ATP-binding site [chemical binding]; other site 1121353002190 DEAD/H associated; Region: DEAD_assoc; pfam08494 1121353002191 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1121353002192 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1121353002193 putative DNA binding site [nucleotide binding]; other site 1121353002194 catalytic residue [active] 1121353002195 putative H2TH interface [polypeptide binding]; other site 1121353002196 putative catalytic residues [active] 1121353002197 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1121353002198 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1121353002199 hypothetical protein; Provisional; Region: PRK11770 1121353002200 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1121353002201 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1121353002202 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1121353002203 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1121353002204 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1121353002205 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1121353002206 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1121353002207 active site 1121353002208 dimer interface [polypeptide binding]; other site 1121353002209 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1121353002210 dimer interface [polypeptide binding]; other site 1121353002211 active site 1121353002212 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1121353002213 active site 1121353002214 hypothetical protein; Provisional; Region: PRK07857 1121353002215 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1121353002216 Part of AAA domain; Region: AAA_19; pfam13245 1121353002217 Family description; Region: UvrD_C_2; pfam13538 1121353002218 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1121353002219 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121353002220 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1121353002221 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1121353002222 active site 1121353002223 substrate binding site [chemical binding]; other site 1121353002224 cosubstrate binding site; other site 1121353002225 catalytic site [active] 1121353002226 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1121353002227 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1121353002228 purine monophosphate binding site [chemical binding]; other site 1121353002229 dimer interface [polypeptide binding]; other site 1121353002230 putative catalytic residues [active] 1121353002231 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1121353002232 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1121353002233 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1121353002234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121353002235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121353002236 30S ribosomal protein S18; Provisional; Region: PRK13401 1121353002237 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1121353002238 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1121353002239 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1121353002240 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1121353002241 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1121353002242 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121353002243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121353002244 active site 1121353002245 phosphorylation site [posttranslational modification] 1121353002246 intermolecular recognition site; other site 1121353002247 dimerization interface [polypeptide binding]; other site 1121353002248 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121353002249 DNA binding site [nucleotide binding] 1121353002250 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121353002251 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121353002252 dimerization interface [polypeptide binding]; other site 1121353002253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121353002254 dimer interface [polypeptide binding]; other site 1121353002255 phosphorylation site [posttranslational modification] 1121353002256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121353002257 ATP binding site [chemical binding]; other site 1121353002258 Mg2+ binding site [ion binding]; other site 1121353002259 G-X-G motif; other site 1121353002260 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1121353002261 protein binding site [polypeptide binding]; other site 1121353002262 PDZ domain; Region: PDZ_2; pfam13180 1121353002263 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1121353002264 MPT binding site; other site 1121353002265 trimer interface [polypeptide binding]; other site 1121353002266 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1121353002267 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1121353002268 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1121353002269 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1121353002270 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1121353002271 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1121353002272 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1121353002273 active site 1121353002274 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1121353002275 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1121353002276 dimer interface [polypeptide binding]; other site 1121353002277 putative functional site; other site 1121353002278 putative MPT binding site; other site 1121353002279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1121353002280 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1121353002281 Predicted membrane protein [Function unknown]; Region: COG2259 1121353002282 Predicted integral membrane protein [Function unknown]; Region: COG5660 1121353002283 Putative zinc-finger; Region: zf-HC2; pfam13490 1121353002284 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 1121353002285 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1121353002286 active site 1121353002287 catalytic site [active] 1121353002288 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1121353002289 Predicted methyltransferases [General function prediction only]; Region: COG0313 1121353002290 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1121353002291 putative SAM binding site [chemical binding]; other site 1121353002292 putative homodimer interface [polypeptide binding]; other site 1121353002293 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1121353002294 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1121353002295 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1121353002296 active site 1121353002297 HIGH motif; other site 1121353002298 KMSKS motif; other site 1121353002299 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1121353002300 tRNA binding surface [nucleotide binding]; other site 1121353002301 anticodon binding site; other site 1121353002302 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1121353002303 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121353002304 ATP binding site [chemical binding]; other site 1121353002305 putative Mg++ binding site [ion binding]; other site 1121353002306 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121353002307 nucleotide binding region [chemical binding]; other site 1121353002308 ATP-binding site [chemical binding]; other site 1121353002309 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1121353002310 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1121353002311 active site 1121353002312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1121353002313 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1121353002314 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1121353002315 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1121353002316 G5 domain; Region: G5; pfam07501 1121353002317 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1121353002318 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1121353002319 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1121353002320 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1121353002321 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1121353002322 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1121353002323 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121353002324 ABC transporter; Region: ABC_tran_2; pfam12848 1121353002325 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121353002326 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1121353002327 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1121353002328 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1121353002329 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121353002330 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121353002331 motif II; other site 1121353002332 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1121353002333 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1121353002334 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1121353002335 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1121353002336 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121353002337 active site 1121353002338 motif I; other site 1121353002339 motif II; other site 1121353002340 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1121353002341 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1121353002342 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1121353002343 substrate binding site [chemical binding]; other site 1121353002344 oxyanion hole (OAH) forming residues; other site 1121353002345 trimer interface [polypeptide binding]; other site 1121353002346 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1121353002347 Predicted membrane protein [General function prediction only]; Region: COG4194 1121353002348 Putative esterase; Region: Esterase; pfam00756 1121353002349 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121353002350 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1121353002351 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1121353002352 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 1121353002353 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1121353002354 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1121353002355 active site 1121353002356 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 1121353002357 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1121353002358 G1 box; other site 1121353002359 putative GEF interaction site [polypeptide binding]; other site 1121353002360 GTP/Mg2+ binding site [chemical binding]; other site 1121353002361 Switch I region; other site 1121353002362 G2 box; other site 1121353002363 G3 box; other site 1121353002364 Switch II region; other site 1121353002365 G4 box; other site 1121353002366 G5 box; other site 1121353002367 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1121353002368 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1121353002369 alpha-gamma subunit interface [polypeptide binding]; other site 1121353002370 beta-gamma subunit interface [polypeptide binding]; other site 1121353002371 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1121353002372 gamma-beta subunit interface [polypeptide binding]; other site 1121353002373 alpha-beta subunit interface [polypeptide binding]; other site 1121353002374 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1121353002375 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1121353002376 subunit interactions [polypeptide binding]; other site 1121353002377 active site 1121353002378 flap region; other site 1121353002379 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1121353002380 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1121353002381 dimer interface [polypeptide binding]; other site 1121353002382 catalytic residues [active] 1121353002383 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1121353002384 UreF; Region: UreF; pfam01730 1121353002385 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121353002386 UreD urease accessory protein; Region: UreD; cl00530 1121353002387 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1121353002388 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1121353002389 putative ligand binding site [chemical binding]; other site 1121353002390 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1121353002391 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121353002392 TM-ABC transporter signature motif; other site 1121353002393 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121353002394 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1121353002395 TM-ABC transporter signature motif; other site 1121353002396 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1121353002397 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1121353002398 Walker A/P-loop; other site 1121353002399 ATP binding site [chemical binding]; other site 1121353002400 Q-loop/lid; other site 1121353002401 ABC transporter signature motif; other site 1121353002402 Walker B; other site 1121353002403 D-loop; other site 1121353002404 H-loop/switch region; other site 1121353002405 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1121353002406 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1121353002407 Walker A/P-loop; other site 1121353002408 ATP binding site [chemical binding]; other site 1121353002409 Q-loop/lid; other site 1121353002410 ABC transporter signature motif; other site 1121353002411 Walker B; other site 1121353002412 D-loop; other site 1121353002413 H-loop/switch region; other site 1121353002414 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1121353002415 putative active site [active] 1121353002416 catalytic residue [active] 1121353002417 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1121353002418 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1121353002419 FMN binding site [chemical binding]; other site 1121353002420 substrate binding site [chemical binding]; other site 1121353002421 putative catalytic residue [active] 1121353002422 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1121353002423 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1121353002424 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1121353002425 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1121353002426 putative active site [active] 1121353002427 catalytic residue [active] 1121353002428 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1121353002429 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1121353002430 5S rRNA interface [nucleotide binding]; other site 1121353002431 CTC domain interface [polypeptide binding]; other site 1121353002432 L16 interface [polypeptide binding]; other site 1121353002433 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1121353002434 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1121353002435 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1121353002436 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 1121353002437 active site 1121353002438 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1121353002439 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1121353002440 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121353002441 active site 1121353002442 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1121353002443 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1121353002444 Substrate binding site; other site 1121353002445 Mg++ binding site; other site 1121353002446 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1121353002447 active site 1121353002448 substrate binding site [chemical binding]; other site 1121353002449 CoA binding site [chemical binding]; other site 1121353002450 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121353002451 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1121353002452 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1121353002453 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1121353002454 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1121353002455 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121353002456 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121353002457 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1121353002458 Q-loop/lid; other site 1121353002459 ABC transporter signature motif; other site 1121353002460 Walker B; other site 1121353002461 D-loop; other site 1121353002462 H-loop/switch region; other site 1121353002463 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121353002464 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121353002465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353002466 Walker A/P-loop; other site 1121353002467 ATP binding site [chemical binding]; other site 1121353002468 Q-loop/lid; other site 1121353002469 ABC transporter signature motif; other site 1121353002470 Walker B; other site 1121353002471 D-loop; other site 1121353002472 H-loop/switch region; other site 1121353002473 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121353002474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121353002475 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1121353002476 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1121353002477 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121353002478 ATP binding site [chemical binding]; other site 1121353002479 putative Mg++ binding site [ion binding]; other site 1121353002480 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121353002481 nucleotide binding region [chemical binding]; other site 1121353002482 ATP-binding site [chemical binding]; other site 1121353002483 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1121353002484 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1121353002485 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1121353002486 Putative esterase; Region: Esterase; pfam00756 1121353002487 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1121353002488 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1121353002489 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1121353002490 homodimer interface [polypeptide binding]; other site 1121353002491 metal binding site [ion binding]; metal-binding site 1121353002492 Alpha helical Porin B; Region: PorB; pfam11565 1121353002493 Alpha helical Porin B; Region: PorB; pfam11565 1121353002494 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1121353002495 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1121353002496 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1121353002497 enolase; Provisional; Region: eno; PRK00077 1121353002498 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1121353002499 dimer interface [polypeptide binding]; other site 1121353002500 metal binding site [ion binding]; metal-binding site 1121353002501 substrate binding pocket [chemical binding]; other site 1121353002502 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1121353002503 Septum formation initiator; Region: DivIC; pfam04977 1121353002504 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1121353002505 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1121353002506 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1121353002507 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1121353002508 DNA-binding site [nucleotide binding]; DNA binding site 1121353002509 RNA-binding motif; other site 1121353002510 short chain dehydrogenase; Validated; Region: PRK08264 1121353002511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121353002512 NAD(P) binding site [chemical binding]; other site 1121353002513 active site 1121353002514 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1121353002515 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1121353002516 FMN binding site [chemical binding]; other site 1121353002517 active site 1121353002518 substrate binding site [chemical binding]; other site 1121353002519 catalytic residue [active] 1121353002520 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121353002521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121353002522 Cupin domain; Region: Cupin_2; cl17218 1121353002523 Predicted membrane protein [Function unknown]; Region: COG4760 1121353002524 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1121353002525 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1121353002526 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1121353002527 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1121353002528 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1121353002529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121353002530 active site 1121353002531 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1121353002532 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1121353002533 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14828 1121353002534 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1121353002535 catalytic residue [active] 1121353002536 putative FPP diphosphate binding site; other site 1121353002537 putative FPP binding hydrophobic cleft; other site 1121353002538 dimer interface [polypeptide binding]; other site 1121353002539 putative IPP diphosphate binding site; other site 1121353002540 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 1121353002541 pantothenate kinase; Provisional; Region: PRK05439 1121353002542 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1121353002543 ATP-binding site [chemical binding]; other site 1121353002544 CoA-binding site [chemical binding]; other site 1121353002545 Mg2+-binding site [ion binding]; other site 1121353002546 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1121353002547 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1121353002548 dimer interface [polypeptide binding]; other site 1121353002549 active site 1121353002550 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1121353002551 folate binding site [chemical binding]; other site 1121353002552 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1121353002553 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1121353002554 glutamine binding [chemical binding]; other site 1121353002555 catalytic triad [active] 1121353002556 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1121353002557 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1121353002558 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1121353002559 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1121353002560 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1121353002561 substrate-cofactor binding pocket; other site 1121353002562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353002563 catalytic residue [active] 1121353002564 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1121353002565 dimerization interface [polypeptide binding]; other site 1121353002566 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1121353002567 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1121353002568 Coenzyme A binding pocket [chemical binding]; other site 1121353002569 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1121353002570 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1121353002571 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1121353002572 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1121353002573 putative active site [active] 1121353002574 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1121353002575 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1121353002576 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121353002577 DNA-binding site [nucleotide binding]; DNA binding site 1121353002578 FCD domain; Region: FCD; pfam07729 1121353002579 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1121353002580 Class II fumarases; Region: Fumarase_classII; cd01362 1121353002581 active site 1121353002582 tetramer interface [polypeptide binding]; other site 1121353002583 Predicted flavoprotein [General function prediction only]; Region: COG0431 1121353002584 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1121353002585 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1121353002586 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1121353002587 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1121353002588 putative active site [active] 1121353002589 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1121353002590 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1121353002591 putative transposase OrfB; Reviewed; Region: PHA02517 1121353002592 HTH-like domain; Region: HTH_21; pfam13276 1121353002593 Integrase core domain; Region: rve; pfam00665 1121353002594 Integrase core domain; Region: rve_3; pfam13683 1121353002595 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1121353002596 Transposase; Region: HTH_Tnp_1; pfam01527 1121353002597 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1121353002598 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1121353002599 dimer interface [polypeptide binding]; other site 1121353002600 ssDNA binding site [nucleotide binding]; other site 1121353002601 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1121353002602 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1121353002603 Transposase; Region: HTH_Tnp_1; pfam01527 1121353002604 putative transposase OrfB; Reviewed; Region: PHA02517 1121353002605 HTH-like domain; Region: HTH_21; pfam13276 1121353002606 Integrase core domain; Region: rve; pfam00665 1121353002607 Integrase core domain; Region: rve_3; pfam13683 1121353002608 Integrase core domain; Region: rve; pfam00665 1121353002609 Integrase core domain; Region: rve_3; pfam13683 1121353002610 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1121353002611 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1121353002612 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1121353002613 generic binding surface II; other site 1121353002614 generic binding surface I; other site 1121353002615 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1121353002616 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1121353002617 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1121353002618 RmuC family; Region: RmuC; pfam02646 1121353002619 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1121353002620 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1121353002621 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1121353002622 Na2 binding site [ion binding]; other site 1121353002623 putative substrate binding site 1 [chemical binding]; other site 1121353002624 Na binding site 1 [ion binding]; other site 1121353002625 putative substrate binding site 2 [chemical binding]; other site 1121353002626 GTP-binding protein YchF; Reviewed; Region: PRK09601 1121353002627 YchF GTPase; Region: YchF; cd01900 1121353002628 G1 box; other site 1121353002629 GTP/Mg2+ binding site [chemical binding]; other site 1121353002630 Switch I region; other site 1121353002631 G2 box; other site 1121353002632 Switch II region; other site 1121353002633 G3 box; other site 1121353002634 G4 box; other site 1121353002635 G5 box; other site 1121353002636 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1121353002637 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121353002638 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121353002639 non-specific DNA binding site [nucleotide binding]; other site 1121353002640 salt bridge; other site 1121353002641 sequence-specific DNA binding site [nucleotide binding]; other site 1121353002642 Cupin domain; Region: Cupin_2; pfam07883 1121353002643 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121353002644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121353002645 S-adenosylmethionine binding site [chemical binding]; other site 1121353002646 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1121353002647 Cation efflux family; Region: Cation_efflux; cl00316 1121353002648 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1121353002649 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1121353002650 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1121353002651 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1121353002652 citrate synthase; Provisional; Region: PRK14033 1121353002653 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1121353002654 oxalacetate binding site [chemical binding]; other site 1121353002655 citrylCoA binding site [chemical binding]; other site 1121353002656 coenzyme A binding site [chemical binding]; other site 1121353002657 catalytic triad [active] 1121353002658 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1121353002659 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1121353002660 tetramer interface [polypeptide binding]; other site 1121353002661 active site 1121353002662 Mg2+/Mn2+ binding site [ion binding]; other site 1121353002663 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1121353002664 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121353002665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121353002666 non-specific DNA binding site [nucleotide binding]; other site 1121353002667 salt bridge; other site 1121353002668 sequence-specific DNA binding site [nucleotide binding]; other site 1121353002669 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1121353002670 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1121353002671 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1121353002672 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1121353002673 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1121353002674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121353002675 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1121353002676 NAD(P) binding site [chemical binding]; other site 1121353002677 active site 1121353002678 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1121353002679 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1121353002680 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1121353002681 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1121353002682 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1121353002683 metal ion-dependent adhesion site (MIDAS); other site 1121353002684 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1121353002685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1121353002686 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121353002687 catalytic core [active] 1121353002688 conserved hypothetical protein; Region: TIGR03843 1121353002689 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1121353002690 tetramer interface [polypeptide binding]; other site 1121353002691 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1121353002692 active site 1121353002693 Mg2+/Mn2+ binding site [ion binding]; other site 1121353002694 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1121353002695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353002696 Walker A/P-loop; other site 1121353002697 ATP binding site [chemical binding]; other site 1121353002698 Q-loop/lid; other site 1121353002699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353002700 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121353002701 ABC transporter signature motif; other site 1121353002702 Walker B; other site 1121353002703 D-loop; other site 1121353002704 ABC transporter; Region: ABC_tran_2; pfam12848 1121353002705 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121353002706 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1121353002707 PhnA protein; Region: PhnA; pfam03831 1121353002708 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121353002709 putative DNA binding site [nucleotide binding]; other site 1121353002710 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1121353002711 putative Zn2+ binding site [ion binding]; other site 1121353002712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353002713 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121353002714 putative substrate translocation pore; other site 1121353002715 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1121353002716 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1121353002717 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121353002718 catalytic residue [active] 1121353002719 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 1121353002720 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1121353002721 dimerization interface [polypeptide binding]; other site 1121353002722 active site 1121353002723 quinolinate synthetase; Provisional; Region: PRK09375 1121353002724 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1121353002725 nudix motif; other site 1121353002726 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1121353002727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1121353002728 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1121353002729 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1121353002730 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1121353002731 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1121353002732 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1121353002733 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 1121353002734 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1121353002735 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121353002736 DNA-binding site [nucleotide binding]; DNA binding site 1121353002737 UTRA domain; Region: UTRA; pfam07702 1121353002738 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1121353002739 dimer interface [polypeptide binding]; other site 1121353002740 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1121353002741 benzoate transport; Region: 2A0115; TIGR00895 1121353002742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353002743 putative substrate translocation pore; other site 1121353002744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353002745 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1121353002746 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121353002747 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1121353002748 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1121353002749 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1121353002750 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1121353002751 Walker A/P-loop; other site 1121353002752 ATP binding site [chemical binding]; other site 1121353002753 Q-loop/lid; other site 1121353002754 ABC transporter signature motif; other site 1121353002755 Walker B; other site 1121353002756 D-loop; other site 1121353002757 H-loop/switch region; other site 1121353002758 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1121353002759 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1121353002760 Walker A/P-loop; other site 1121353002761 ATP binding site [chemical binding]; other site 1121353002762 Q-loop/lid; other site 1121353002763 ABC transporter signature motif; other site 1121353002764 Walker B; other site 1121353002765 D-loop; other site 1121353002766 H-loop/switch region; other site 1121353002767 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1121353002768 hypothetical protein; Provisional; Region: PRK06547 1121353002769 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1121353002770 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1121353002771 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353002772 Walker A/P-loop; other site 1121353002773 ATP binding site [chemical binding]; other site 1121353002774 Q-loop/lid; other site 1121353002775 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1121353002776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353002777 AAA domain; Region: AAA_21; pfam13304 1121353002778 Walker A/P-loop; other site 1121353002779 ATP binding site [chemical binding]; other site 1121353002780 Q-loop/lid; other site 1121353002781 ABC transporter signature motif; other site 1121353002782 Walker B; other site 1121353002783 D-loop; other site 1121353002784 H-loop/switch region; other site 1121353002785 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1121353002786 dimer interface [polypeptide binding]; other site 1121353002787 catalytic triad [active] 1121353002788 peroxidatic and resolving cysteines [active] 1121353002789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 1121353002790 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1121353002791 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1121353002792 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1121353002793 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 1121353002794 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1121353002795 nudix motif; other site 1121353002796 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1121353002797 Trypsin; Region: Trypsin; pfam00089 1121353002798 active site 1121353002799 substrate binding sites [chemical binding]; other site 1121353002800 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1121353002801 ArsC family; Region: ArsC; pfam03960 1121353002802 catalytic residues [active] 1121353002803 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1121353002804 Protein of unknown function (DUF402); Region: DUF402; cl00979 1121353002805 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1121353002806 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1121353002807 G1 box; other site 1121353002808 GTP/Mg2+ binding site [chemical binding]; other site 1121353002809 G2 box; other site 1121353002810 Switch I region; other site 1121353002811 G3 box; other site 1121353002812 Switch II region; other site 1121353002813 G4 box; other site 1121353002814 G5 box; other site 1121353002815 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1121353002816 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1121353002817 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1121353002818 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1121353002819 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1121353002820 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1121353002821 Ferredoxin [Energy production and conversion]; Region: COG1146 1121353002822 4Fe-4S binding domain; Region: Fer4; pfam00037 1121353002823 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1121353002824 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121353002825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353002826 homodimer interface [polypeptide binding]; other site 1121353002827 catalytic residue [active] 1121353002828 Predicted membrane protein [Function unknown]; Region: COG2246 1121353002829 GtrA-like protein; Region: GtrA; pfam04138 1121353002830 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1121353002831 active site 1121353002832 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1121353002833 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1121353002834 putative trimer interface [polypeptide binding]; other site 1121353002835 putative CoA binding site [chemical binding]; other site 1121353002836 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1121353002837 Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171 1121353002838 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121353002839 putative trimer interface [polypeptide binding]; other site 1121353002840 putative CoA binding site [chemical binding]; other site 1121353002841 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1121353002842 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1121353002843 metal binding site [ion binding]; metal-binding site 1121353002844 putative dimer interface [polypeptide binding]; other site 1121353002845 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1121353002846 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1121353002847 dihydropteroate synthase; Region: DHPS; TIGR01496 1121353002848 substrate binding pocket [chemical binding]; other site 1121353002849 dimer interface [polypeptide binding]; other site 1121353002850 inhibitor binding site; inhibition site 1121353002851 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1121353002852 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1121353002853 Ligand binding site; other site 1121353002854 Putative Catalytic site; other site 1121353002855 DXD motif; other site 1121353002856 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1121353002857 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1121353002858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121353002859 S-adenosylmethionine binding site [chemical binding]; other site 1121353002860 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1121353002861 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1121353002862 active site 1121353002863 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1121353002864 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1121353002865 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121353002866 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1121353002867 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1121353002868 ligand binding site; other site 1121353002869 oligomer interface; other site 1121353002870 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1121353002871 N-terminal domain interface [polypeptide binding]; other site 1121353002872 sulfate 1 binding site; other site 1121353002873 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1121353002874 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1121353002875 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1121353002876 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121353002877 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121353002878 DNA binding residues [nucleotide binding] 1121353002879 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1121353002880 sec-independent translocase; Provisional; Region: tatB; PRK00182 1121353002881 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1121353002882 Domain of unknown function DUF59; Region: DUF59; pfam01883 1121353002883 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1121353002884 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1121353002885 Predicted membrane protein [Function unknown]; Region: COG4420 1121353002886 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1121353002887 MgtE intracellular N domain; Region: MgtE_N; smart00924 1121353002888 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1121353002889 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1121353002890 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1121353002891 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1121353002892 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1121353002893 TPP-binding site [chemical binding]; other site 1121353002894 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1121353002895 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121353002896 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121353002897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353002898 Walker A/P-loop; other site 1121353002899 ATP binding site [chemical binding]; other site 1121353002900 Q-loop/lid; other site 1121353002901 ABC transporter signature motif; other site 1121353002902 Walker B; other site 1121353002903 D-loop; other site 1121353002904 H-loop/switch region; other site 1121353002905 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121353002906 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121353002907 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353002908 Walker A/P-loop; other site 1121353002909 ATP binding site [chemical binding]; other site 1121353002910 Q-loop/lid; other site 1121353002911 ABC transporter signature motif; other site 1121353002912 Walker B; other site 1121353002913 D-loop; other site 1121353002914 H-loop/switch region; other site 1121353002915 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1121353002916 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1121353002917 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1121353002918 shikimate binding site; other site 1121353002919 NAD(P) binding site [chemical binding]; other site 1121353002920 Predicted thioesterase [General function prediction only]; Region: COG5496 1121353002921 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1121353002922 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1121353002923 substrate binding pocket [chemical binding]; other site 1121353002924 catalytic triad [active] 1121353002925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353002926 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121353002927 putative substrate translocation pore; other site 1121353002928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353002929 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121353002930 putative substrate translocation pore; other site 1121353002931 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1121353002932 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1121353002933 THF binding site; other site 1121353002934 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1121353002935 substrate binding site [chemical binding]; other site 1121353002936 THF binding site; other site 1121353002937 zinc-binding site [ion binding]; other site 1121353002938 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1121353002939 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1121353002940 active site 1121353002941 nucleophile elbow; other site 1121353002942 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1121353002943 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1121353002944 Condensation domain; Region: Condensation; pfam00668 1121353002945 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1121353002946 PLD-like domain; Region: PLDc_2; pfam13091 1121353002947 putative homodimer interface [polypeptide binding]; other site 1121353002948 putative active site [active] 1121353002949 catalytic site [active] 1121353002950 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 1121353002951 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121353002952 ATP binding site [chemical binding]; other site 1121353002953 putative Mg++ binding site [ion binding]; other site 1121353002954 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121353002955 nucleotide binding region [chemical binding]; other site 1121353002956 ATP-binding site [chemical binding]; other site 1121353002957 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1121353002958 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1121353002959 active site 1121353002960 8-oxo-dGMP binding site [chemical binding]; other site 1121353002961 nudix motif; other site 1121353002962 metal binding site [ion binding]; metal-binding site 1121353002963 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1121353002964 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353002965 Q-loop/lid; other site 1121353002966 ABC transporter signature motif; other site 1121353002967 Walker B; other site 1121353002968 D-loop; other site 1121353002969 H-loop/switch region; other site 1121353002970 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1121353002971 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121353002972 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1121353002973 Walker A/P-loop; other site 1121353002974 ATP binding site [chemical binding]; other site 1121353002975 Q-loop/lid; other site 1121353002976 ABC transporter signature motif; other site 1121353002977 Walker B; other site 1121353002978 D-loop; other site 1121353002979 H-loop/switch region; other site 1121353002980 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1121353002981 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1121353002982 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1121353002983 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 1121353002984 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1121353002985 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 1121353002986 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1121353002987 ATP binding site [chemical binding]; other site 1121353002988 Mg++ binding site [ion binding]; other site 1121353002989 motif III; other site 1121353002990 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121353002991 nucleotide binding region [chemical binding]; other site 1121353002992 ATP-binding site [chemical binding]; other site 1121353002993 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1121353002994 putative RNA binding site [nucleotide binding]; other site 1121353002995 potential frameshift: common BLAST hit: gi|62390080|ref|YP_225482.1| phospholipid phosphatase 1121353002996 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121353002997 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121353002998 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 1121353002999 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1121353003000 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1121353003001 active site 1121353003002 dimer interface [polypeptide binding]; other site 1121353003003 metal binding site [ion binding]; metal-binding site 1121353003004 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1121353003005 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1121353003006 Na binding site [ion binding]; other site 1121353003007 SNF2 Helicase protein; Region: DUF3670; pfam12419 1121353003008 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1121353003009 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121353003010 ATP binding site [chemical binding]; other site 1121353003011 putative Mg++ binding site [ion binding]; other site 1121353003012 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121353003013 nucleotide binding region [chemical binding]; other site 1121353003014 ATP-binding site [chemical binding]; other site 1121353003015 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1121353003016 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1121353003017 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1121353003018 active site 1121353003019 metal binding site [ion binding]; metal-binding site 1121353003020 DNA binding site [nucleotide binding] 1121353003021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353003022 Walker A/P-loop; other site 1121353003023 ATP binding site [chemical binding]; other site 1121353003024 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cl10029 1121353003025 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1121353003026 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1121353003027 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1121353003028 PspC domain; Region: PspC; pfam04024 1121353003029 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1121353003030 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1121353003031 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1121353003032 active site 1121353003033 HIGH motif; other site 1121353003034 KMSK motif region; other site 1121353003035 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1121353003036 tRNA binding surface [nucleotide binding]; other site 1121353003037 anticodon binding site; other site 1121353003038 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1121353003039 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1121353003040 active site 1121353003041 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121353003042 substrate binding site [chemical binding]; other site 1121353003043 catalytic residues [active] 1121353003044 dimer interface [polypeptide binding]; other site 1121353003045 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121353003046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121353003047 active site 1121353003048 phosphorylation site [posttranslational modification] 1121353003049 intermolecular recognition site; other site 1121353003050 dimerization interface [polypeptide binding]; other site 1121353003051 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121353003052 DNA binding residues [nucleotide binding] 1121353003053 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1121353003054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121353003055 ATP binding site [chemical binding]; other site 1121353003056 Mg2+ binding site [ion binding]; other site 1121353003057 G-X-G motif; other site 1121353003058 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1121353003059 homoserine dehydrogenase; Provisional; Region: PRK06349 1121353003060 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1121353003061 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1121353003062 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1121353003063 homoserine kinase; Provisional; Region: PRK01212 1121353003064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1121353003065 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121353003066 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 1121353003067 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121353003068 acyl-activating enzyme (AAE) consensus motif; other site 1121353003069 AMP binding site [chemical binding]; other site 1121353003070 active site 1121353003071 CoA binding site [chemical binding]; other site 1121353003072 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1121353003073 transcription termination factor Rho; Provisional; Region: PRK12608 1121353003074 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1121353003075 RNA binding site [nucleotide binding]; other site 1121353003076 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1121353003077 multimer interface [polypeptide binding]; other site 1121353003078 Walker A motif; other site 1121353003079 ATP binding site [chemical binding]; other site 1121353003080 Walker B motif; other site 1121353003081 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1121353003082 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1121353003083 RF-1 domain; Region: RF-1; pfam00472 1121353003084 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1121353003085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121353003086 S-adenosylmethionine binding site [chemical binding]; other site 1121353003087 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1121353003088 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1121353003089 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1121353003090 Mg++ binding site [ion binding]; other site 1121353003091 putative catalytic motif [active] 1121353003092 substrate binding site [chemical binding]; other site 1121353003093 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1121353003094 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1121353003095 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 1121353003096 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1121353003097 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1121353003098 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1121353003099 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1121353003100 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1121353003101 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121353003102 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1121353003103 beta subunit interaction interface [polypeptide binding]; other site 1121353003104 Walker A motif; other site 1121353003105 ATP binding site [chemical binding]; other site 1121353003106 Walker B motif; other site 1121353003107 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1121353003108 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1121353003109 core domain interface [polypeptide binding]; other site 1121353003110 delta subunit interface [polypeptide binding]; other site 1121353003111 epsilon subunit interface [polypeptide binding]; other site 1121353003112 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1121353003113 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121353003114 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1121353003115 alpha subunit interaction interface [polypeptide binding]; other site 1121353003116 Walker A motif; other site 1121353003117 ATP binding site [chemical binding]; other site 1121353003118 Walker B motif; other site 1121353003119 inhibitor binding site; inhibition site 1121353003120 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1121353003121 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1121353003122 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1121353003123 gamma subunit interface [polypeptide binding]; other site 1121353003124 epsilon subunit interface [polypeptide binding]; other site 1121353003125 LBP interface [polypeptide binding]; other site 1121353003126 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1121353003127 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1121353003128 hypothetical protein; Provisional; Region: PRK03298 1121353003129 Domain of unknown function DUF77; Region: DUF77; pfam01910 1121353003130 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1121353003131 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1121353003132 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1121353003133 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1121353003134 dimer interface [polypeptide binding]; other site 1121353003135 active site 1121353003136 non-prolyl cis peptide bond; other site 1121353003137 insertion regions; other site 1121353003138 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1121353003139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353003140 dimer interface [polypeptide binding]; other site 1121353003141 conserved gate region; other site 1121353003142 putative PBP binding loops; other site 1121353003143 ABC-ATPase subunit interface; other site 1121353003144 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1121353003145 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1121353003146 Walker A/P-loop; other site 1121353003147 ATP binding site [chemical binding]; other site 1121353003148 Q-loop/lid; other site 1121353003149 ABC transporter signature motif; other site 1121353003150 Walker B; other site 1121353003151 D-loop; other site 1121353003152 H-loop/switch region; other site 1121353003153 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1121353003154 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121353003155 substrate binding pocket [chemical binding]; other site 1121353003156 membrane-bound complex binding site; other site 1121353003157 hinge residues; other site 1121353003158 glycogen branching enzyme; Provisional; Region: PRK05402 1121353003159 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1121353003160 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1121353003161 active site 1121353003162 catalytic site [active] 1121353003163 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1121353003164 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1121353003165 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1121353003166 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1121353003167 active site 1121353003168 catalytic site [active] 1121353003169 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1121353003170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353003171 Walker A/P-loop; other site 1121353003172 ATP binding site [chemical binding]; other site 1121353003173 Q-loop/lid; other site 1121353003174 ABC transporter signature motif; other site 1121353003175 Walker B; other site 1121353003176 D-loop; other site 1121353003177 H-loop/switch region; other site 1121353003178 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1121353003179 Ligand binding site [chemical binding]; other site 1121353003180 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1121353003181 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1121353003182 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1121353003183 Ligand Binding Site [chemical binding]; other site 1121353003184 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1121353003185 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1121353003186 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1121353003187 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121353003188 catalytic residue [active] 1121353003189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1121353003190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121353003191 S-adenosylmethionine binding site [chemical binding]; other site 1121353003192 AAA ATPase domain; Region: AAA_16; pfam13191 1121353003193 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1121353003194 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1121353003195 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1121353003196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353003197 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121353003198 putative substrate translocation pore; other site 1121353003199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353003200 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1121353003201 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1121353003202 active site 1121353003203 catalytic site [active] 1121353003204 substrate binding site [chemical binding]; other site 1121353003205 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1121353003206 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1121353003207 nucleotide binding pocket [chemical binding]; other site 1121353003208 K-X-D-G motif; other site 1121353003209 catalytic site [active] 1121353003210 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1121353003211 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1121353003212 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1121353003213 Dimer interface [polypeptide binding]; other site 1121353003214 BRCT sequence motif; other site 1121353003215 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 1121353003216 Active site serine [active] 1121353003217 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1121353003218 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1121353003219 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1121353003220 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1121353003221 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1121353003222 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1121353003223 FAD binding pocket [chemical binding]; other site 1121353003224 FAD binding motif [chemical binding]; other site 1121353003225 phosphate binding motif [ion binding]; other site 1121353003226 NAD binding pocket [chemical binding]; other site 1121353003227 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1121353003228 phosphofructokinase; Region: PFK_mixed; TIGR02483 1121353003229 active site 1121353003230 ADP/pyrophosphate binding site [chemical binding]; other site 1121353003231 dimerization interface [polypeptide binding]; other site 1121353003232 allosteric effector site; other site 1121353003233 fructose-1,6-bisphosphate binding site; other site 1121353003234 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121353003235 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121353003236 DNA binding site [nucleotide binding] 1121353003237 domain linker motif; other site 1121353003238 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 1121353003239 dimerization interface [polypeptide binding]; other site 1121353003240 putative ligand binding site [chemical binding]; other site 1121353003241 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1121353003242 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1121353003243 Walker A/P-loop; other site 1121353003244 ATP binding site [chemical binding]; other site 1121353003245 Q-loop/lid; other site 1121353003246 ABC transporter signature motif; other site 1121353003247 Walker B; other site 1121353003248 D-loop; other site 1121353003249 H-loop/switch region; other site 1121353003250 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1121353003251 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121353003252 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1121353003253 TM-ABC transporter signature motif; other site 1121353003254 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1121353003255 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1121353003256 ligand binding site [chemical binding]; other site 1121353003257 dimerization interface [polypeptide binding]; other site 1121353003258 D-ribose pyranase; Provisional; Region: PRK11797 1121353003259 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1121353003260 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1121353003261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1121353003262 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1121353003263 Sodium Bile acid symporter family; Region: SBF; pfam01758 1121353003264 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1121353003265 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1121353003266 GatB domain; Region: GatB_Yqey; smart00845 1121353003267 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1121353003268 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1121353003269 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121353003270 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1121353003271 active site 1121353003272 catalytic tetrad [active] 1121353003273 L-lysine exporter; Region: 2a75; TIGR00948 1121353003274 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1121353003275 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121353003276 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1121353003277 dimerization interface [polypeptide binding]; other site 1121353003278 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1121353003279 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1121353003280 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1121353003281 putative dimer interface [polypeptide binding]; other site 1121353003282 N-terminal domain interface [polypeptide binding]; other site 1121353003283 putative substrate binding pocket (H-site) [chemical binding]; other site 1121353003284 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1121353003285 Predicted membrane protein [Function unknown]; Region: COG2259 1121353003286 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1121353003287 Cation efflux family; Region: Cation_efflux; cl00316 1121353003288 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121353003289 dimerization interface [polypeptide binding]; other site 1121353003290 putative DNA binding site [nucleotide binding]; other site 1121353003291 putative Zn2+ binding site [ion binding]; other site 1121353003292 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1121353003293 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1121353003294 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1121353003295 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1121353003296 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1121353003297 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1121353003298 PYR/PP interface [polypeptide binding]; other site 1121353003299 dimer interface [polypeptide binding]; other site 1121353003300 TPP binding site [chemical binding]; other site 1121353003301 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1121353003302 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1121353003303 TPP-binding site [chemical binding]; other site 1121353003304 dimer interface [polypeptide binding]; other site 1121353003305 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1121353003306 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1121353003307 putative valine binding site [chemical binding]; other site 1121353003308 dimer interface [polypeptide binding]; other site 1121353003309 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1121353003310 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1121353003311 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1121353003312 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1121353003313 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1121353003314 Protein of unknown function DUF262; Region: DUF262; pfam03235 1121353003315 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1121353003316 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1121353003317 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1121353003318 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1121353003319 ligand binding site [chemical binding]; other site 1121353003320 NAD binding site [chemical binding]; other site 1121353003321 dimerization interface [polypeptide binding]; other site 1121353003322 catalytic site [active] 1121353003323 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1121353003324 putative L-serine binding site [chemical binding]; other site 1121353003325 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1121353003326 tartrate dehydrogenase; Region: TTC; TIGR02089 1121353003327 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1121353003328 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1121353003329 ligand binding site [chemical binding]; other site 1121353003330 flexible hinge region; other site 1121353003331 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1121353003332 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1121353003333 metal binding triad; other site 1121353003334 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1121353003335 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1121353003336 active site 1121353003337 catalytic site [active] 1121353003338 substrate binding site [chemical binding]; other site 1121353003339 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1121353003340 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1121353003341 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1121353003342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1121353003343 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1121353003344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121353003345 S-adenosylmethionine binding site [chemical binding]; other site 1121353003346 YcfA-like protein; Region: YcfA; pfam07927 1121353003347 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1121353003348 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1121353003349 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1121353003350 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1121353003351 active site 1121353003352 HIGH motif; other site 1121353003353 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1121353003354 active site 1121353003355 KMSKS motif; other site 1121353003356 Predicted transcriptional regulator [Transcription]; Region: COG3655 1121353003357 salt bridge; other site 1121353003358 non-specific DNA binding site [nucleotide binding]; other site 1121353003359 sequence-specific DNA binding site [nucleotide binding]; other site 1121353003360 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1121353003361 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 1121353003362 putative hydrophobic ligand binding site [chemical binding]; other site 1121353003363 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1121353003364 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121353003365 ATP binding site [chemical binding]; other site 1121353003366 putative Mg++ binding site [ion binding]; other site 1121353003367 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1121353003368 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121353003369 nucleotide binding region [chemical binding]; other site 1121353003370 ATP-binding site [chemical binding]; other site 1121353003371 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1121353003372 DNA methylase; Region: N6_N4_Mtase; pfam01555 1121353003373 Restriction endonuclease [Defense mechanisms]; Region: COG3587 1121353003374 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121353003375 ATP binding site [chemical binding]; other site 1121353003376 putative Mg++ binding site [ion binding]; other site 1121353003377 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1121353003378 AAA domain; Region: AAA_21; pfam13304 1121353003379 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1121353003380 putative active site [active] 1121353003381 putative metal-binding site [ion binding]; other site 1121353003382 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1121353003383 Family description; Region: UvrD_C_2; pfam13538 1121353003384 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1121353003385 Uncharacterized conserved protein [Function unknown]; Region: COG3586 1121353003386 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1121353003387 ThiC-associated domain; Region: ThiC-associated; pfam13667 1121353003388 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1121353003389 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1121353003390 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1121353003391 homodimer interface [polypeptide binding]; other site 1121353003392 active site pocket [active] 1121353003393 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1121353003394 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121353003395 active site residue [active] 1121353003396 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1121353003397 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1121353003398 HD domain; Region: HD_4; pfam13328 1121353003399 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1121353003400 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1121353003401 Bacterial transcriptional regulator; Region: IclR; pfam01614 1121353003402 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1121353003403 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1121353003404 substrate binding site [chemical binding]; other site 1121353003405 ligand binding site [chemical binding]; other site 1121353003406 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1121353003407 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1121353003408 substrate binding site [chemical binding]; other site 1121353003409 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1121353003410 active site 1121353003411 Ap6A binding site [chemical binding]; other site 1121353003412 nudix motif; other site 1121353003413 metal binding site [ion binding]; metal-binding site 1121353003414 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121353003415 catalytic core [active] 1121353003416 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1121353003417 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1121353003418 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1121353003419 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1121353003420 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1121353003421 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121353003422 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1121353003423 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1121353003424 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1121353003425 thiamine monophosphate kinase; Provisional; Region: PRK05731 1121353003426 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1121353003427 ATP binding site [chemical binding]; other site 1121353003428 dimerization interface [polypeptide binding]; other site 1121353003429 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1121353003430 ligand binding site [chemical binding]; other site 1121353003431 active site 1121353003432 UGI interface [polypeptide binding]; other site 1121353003433 catalytic site [active] 1121353003434 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1121353003435 DAK2 domain; Region: Dak2; pfam02734 1121353003436 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 1121353003437 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1121353003438 generic binding surface II; other site 1121353003439 ssDNA binding site; other site 1121353003440 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121353003441 ATP binding site [chemical binding]; other site 1121353003442 putative Mg++ binding site [ion binding]; other site 1121353003443 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121353003444 nucleotide binding region [chemical binding]; other site 1121353003445 ATP-binding site [chemical binding]; other site 1121353003446 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1121353003447 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1121353003448 carboxyltransferase (CT) interaction site; other site 1121353003449 biotinylation site [posttranslational modification]; other site 1121353003450 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1121353003451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121353003452 S-adenosylmethionine binding site [chemical binding]; other site 1121353003453 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1121353003454 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1121353003455 active site 1121353003456 (T/H)XGH motif; other site 1121353003457 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1121353003458 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1121353003459 Walker A/P-loop; other site 1121353003460 ATP binding site [chemical binding]; other site 1121353003461 Q-loop/lid; other site 1121353003462 ABC transporter signature motif; other site 1121353003463 Walker B; other site 1121353003464 D-loop; other site 1121353003465 H-loop/switch region; other site 1121353003466 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1121353003467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353003468 dimer interface [polypeptide binding]; other site 1121353003469 conserved gate region; other site 1121353003470 putative PBP binding loops; other site 1121353003471 ABC-ATPase subunit interface; other site 1121353003472 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121353003473 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121353003474 substrate binding pocket [chemical binding]; other site 1121353003475 membrane-bound complex binding site; other site 1121353003476 hinge residues; other site 1121353003477 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1121353003478 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1121353003479 NAD(P) binding site [chemical binding]; other site 1121353003480 putative active site [active] 1121353003481 SnoaL-like domain; Region: SnoaL_4; pfam13577 1121353003482 SnoaL-like domain; Region: SnoaL_4; pfam13577 1121353003483 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1121353003484 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1121353003485 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1121353003486 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121353003487 dimerization interface [polypeptide binding]; other site 1121353003488 putative DNA binding site [nucleotide binding]; other site 1121353003489 putative Zn2+ binding site [ion binding]; other site 1121353003490 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1121353003491 hypothetical protein; Validated; Region: PRK07581 1121353003492 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1121353003493 short chain dehydrogenase; Provisional; Region: PRK06180 1121353003494 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1121353003495 NADP binding site [chemical binding]; other site 1121353003496 active site 1121353003497 steroid binding site; other site 1121353003498 DNA polymerase I; Provisional; Region: PRK05755 1121353003499 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1121353003500 active site 1121353003501 metal binding site 1 [ion binding]; metal-binding site 1121353003502 putative 5' ssDNA interaction site; other site 1121353003503 metal binding site 3; metal-binding site 1121353003504 metal binding site 2 [ion binding]; metal-binding site 1121353003505 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1121353003506 putative DNA binding site [nucleotide binding]; other site 1121353003507 putative metal binding site [ion binding]; other site 1121353003508 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1121353003509 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1121353003510 active site 1121353003511 DNA binding site [nucleotide binding] 1121353003512 catalytic site [active] 1121353003513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353003514 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121353003515 putative substrate translocation pore; other site 1121353003516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353003517 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1121353003518 SnoaL-like domain; Region: SnoaL_3; pfam13474 1121353003519 Helix-turn-helix domain; Region: HTH_31; pfam13560 1121353003520 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121353003521 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1121353003522 active site 1121353003523 catalytic tetrad [active] 1121353003524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121353003525 S-adenosylmethionine binding site [chemical binding]; other site 1121353003526 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1121353003527 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1121353003528 RNA binding site [nucleotide binding]; other site 1121353003529 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1121353003530 RNA binding site [nucleotide binding]; other site 1121353003531 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1121353003532 RNA binding site [nucleotide binding]; other site 1121353003533 S1 RNA binding domain; Region: S1; pfam00575 1121353003534 RNA binding site [nucleotide binding]; other site 1121353003535 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1121353003536 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1121353003537 active site turn [active] 1121353003538 phosphorylation site [posttranslational modification] 1121353003539 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1121353003540 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1121353003541 HPr interaction site; other site 1121353003542 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1121353003543 active site 1121353003544 phosphorylation site [posttranslational modification] 1121353003545 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1121353003546 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1121353003547 CoA-binding site [chemical binding]; other site 1121353003548 ATP-binding [chemical binding]; other site 1121353003549 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 1121353003550 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1121353003551 heme-binding site [chemical binding]; other site 1121353003552 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1121353003553 active site 1121353003554 tetramer interface [polypeptide binding]; other site 1121353003555 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1121353003556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353003557 putative substrate translocation pore; other site 1121353003558 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1121353003559 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1121353003560 substrate binding site [chemical binding]; other site 1121353003561 dimer interface [polypeptide binding]; other site 1121353003562 ATP binding site [chemical binding]; other site 1121353003563 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121353003564 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121353003565 DNA binding site [nucleotide binding] 1121353003566 domain linker motif; other site 1121353003567 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 1121353003568 dimerization interface [polypeptide binding]; other site 1121353003569 putative ligand binding site [chemical binding]; other site 1121353003570 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121353003571 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1121353003572 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121353003573 active site 1121353003574 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121353003575 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121353003576 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1121353003577 putative ADP-binding pocket [chemical binding]; other site 1121353003578 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1121353003579 excinuclease ABC subunit B; Provisional; Region: PRK05298 1121353003580 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121353003581 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121353003582 nucleotide binding region [chemical binding]; other site 1121353003583 ATP-binding site [chemical binding]; other site 1121353003584 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1121353003585 UvrB/uvrC motif; Region: UVR; pfam02151 1121353003586 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121353003587 Ligand Binding Site [chemical binding]; other site 1121353003588 Predicted transcriptional regulators [Transcription]; Region: COG1733 1121353003589 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1121353003590 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1121353003591 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1121353003592 NADP binding site [chemical binding]; other site 1121353003593 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1121353003594 Part of AAA domain; Region: AAA_19; pfam13245 1121353003595 Family description; Region: UvrD_C_2; pfam13538 1121353003596 Predicted membrane protein [Function unknown]; Region: COG2259 1121353003597 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1121353003598 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1121353003599 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1121353003600 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1121353003601 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1121353003602 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1121353003603 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1121353003604 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1121353003605 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1121353003606 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1121353003607 23S rRNA binding site [nucleotide binding]; other site 1121353003608 L21 binding site [polypeptide binding]; other site 1121353003609 L13 binding site [polypeptide binding]; other site 1121353003610 YCII-related domain; Region: YCII; cl00999 1121353003611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353003612 dimer interface [polypeptide binding]; other site 1121353003613 conserved gate region; other site 1121353003614 putative PBP binding loops; other site 1121353003615 ABC-ATPase subunit interface; other site 1121353003616 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121353003617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353003618 dimer interface [polypeptide binding]; other site 1121353003619 conserved gate region; other site 1121353003620 putative PBP binding loops; other site 1121353003621 ABC-ATPase subunit interface; other site 1121353003622 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121353003623 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1121353003624 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1121353003625 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1121353003626 Walker A/P-loop; other site 1121353003627 ATP binding site [chemical binding]; other site 1121353003628 Q-loop/lid; other site 1121353003629 ABC transporter signature motif; other site 1121353003630 Walker B; other site 1121353003631 D-loop; other site 1121353003632 H-loop/switch region; other site 1121353003633 TOBE domain; Region: TOBE_2; pfam08402 1121353003634 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1121353003635 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 1121353003636 active site 1121353003637 catalytic site [active] 1121353003638 metal binding site [ion binding]; metal-binding site 1121353003639 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1121353003640 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1121353003641 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1121353003642 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1121353003643 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1121353003644 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1121353003645 dimer interface [polypeptide binding]; other site 1121353003646 motif 1; other site 1121353003647 active site 1121353003648 motif 2; other site 1121353003649 motif 3; other site 1121353003650 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1121353003651 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1121353003652 putative tRNA-binding site [nucleotide binding]; other site 1121353003653 B3/4 domain; Region: B3_4; pfam03483 1121353003654 tRNA synthetase B5 domain; Region: B5; smart00874 1121353003655 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1121353003656 dimer interface [polypeptide binding]; other site 1121353003657 motif 1; other site 1121353003658 motif 3; other site 1121353003659 motif 2; other site 1121353003660 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1121353003661 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1121353003662 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1121353003663 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1121353003664 heterotetramer interface [polypeptide binding]; other site 1121353003665 active site pocket [active] 1121353003666 cleavage site 1121353003667 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1121353003668 feedback inhibition sensing region; other site 1121353003669 homohexameric interface [polypeptide binding]; other site 1121353003670 nucleotide binding site [chemical binding]; other site 1121353003671 N-acetyl-L-glutamate binding site [chemical binding]; other site 1121353003672 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1121353003673 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1121353003674 inhibitor-cofactor binding pocket; inhibition site 1121353003675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353003676 catalytic residue [active] 1121353003677 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1121353003678 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1121353003679 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1121353003680 arginine repressor; Provisional; Region: PRK03341 1121353003681 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1121353003682 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1121353003683 argininosuccinate synthase; Provisional; Region: PRK13820 1121353003684 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1121353003685 ANP binding site [chemical binding]; other site 1121353003686 Substrate Binding Site II [chemical binding]; other site 1121353003687 Substrate Binding Site I [chemical binding]; other site 1121353003688 argininosuccinate lyase; Provisional; Region: PRK00855 1121353003689 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1121353003690 active sites [active] 1121353003691 tetramer interface [polypeptide binding]; other site 1121353003692 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1121353003693 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1121353003694 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1121353003695 active site 1121353003696 HIGH motif; other site 1121353003697 dimer interface [polypeptide binding]; other site 1121353003698 KMSKS motif; other site 1121353003699 S4 RNA-binding domain; Region: S4; smart00363 1121353003700 RNA binding surface [nucleotide binding]; other site 1121353003701 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1121353003702 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1121353003703 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121353003704 active site 1121353003705 motif I; other site 1121353003706 motif II; other site 1121353003707 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121353003708 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1121353003709 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121353003710 RNA binding surface [nucleotide binding]; other site 1121353003711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121353003712 S-adenosylmethionine binding site [chemical binding]; other site 1121353003713 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1121353003714 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1121353003715 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1121353003716 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1121353003717 Walker A/P-loop; other site 1121353003718 ATP binding site [chemical binding]; other site 1121353003719 Q-loop/lid; other site 1121353003720 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1121353003721 ABC transporter signature motif; other site 1121353003722 Walker B; other site 1121353003723 D-loop; other site 1121353003724 H-loop/switch region; other site 1121353003725 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1121353003726 Thiamine pyrophosphokinase; Region: TPK; cl08415 1121353003727 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1121353003728 CTP synthetase; Validated; Region: pyrG; PRK05380 1121353003729 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1121353003730 Catalytic site [active] 1121353003731 active site 1121353003732 UTP binding site [chemical binding]; other site 1121353003733 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1121353003734 active site 1121353003735 putative oxyanion hole; other site 1121353003736 catalytic triad [active] 1121353003737 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1121353003738 dimer interface [polypeptide binding]; other site 1121353003739 ADP-ribose binding site [chemical binding]; other site 1121353003740 active site 1121353003741 nudix motif; other site 1121353003742 metal binding site [ion binding]; metal-binding site 1121353003743 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1121353003744 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1121353003745 active site 1121353003746 Int/Topo IB signature motif; other site 1121353003747 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1121353003748 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121353003749 P-loop; other site 1121353003750 Magnesium ion binding site [ion binding]; other site 1121353003751 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1121353003752 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1121353003753 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1121353003754 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1121353003755 active site residue [active] 1121353003756 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1121353003757 active site residue [active] 1121353003758 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1121353003759 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1121353003760 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121353003761 RNA binding surface [nucleotide binding]; other site 1121353003762 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1121353003763 active site 1121353003764 cytidylate kinase; Provisional; Region: cmk; PRK00023 1121353003765 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1121353003766 CMP-binding site; other site 1121353003767 The sites determining sugar specificity; other site 1121353003768 GTP-binding protein Der; Reviewed; Region: PRK03003 1121353003769 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1121353003770 G1 box; other site 1121353003771 GTP/Mg2+ binding site [chemical binding]; other site 1121353003772 Switch I region; other site 1121353003773 G2 box; other site 1121353003774 Switch II region; other site 1121353003775 G3 box; other site 1121353003776 G4 box; other site 1121353003777 G5 box; other site 1121353003778 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1121353003779 G1 box; other site 1121353003780 GTP/Mg2+ binding site [chemical binding]; other site 1121353003781 Switch I region; other site 1121353003782 G2 box; other site 1121353003783 G3 box; other site 1121353003784 Switch II region; other site 1121353003785 G4 box; other site 1121353003786 G5 box; other site 1121353003787 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1121353003788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121353003789 S-adenosylmethionine binding site [chemical binding]; other site 1121353003790 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121353003791 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121353003792 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353003793 Walker B; other site 1121353003794 D-loop; other site 1121353003795 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121353003796 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121353003797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353003798 Walker A/P-loop; other site 1121353003799 ATP binding site [chemical binding]; other site 1121353003800 Q-loop/lid; other site 1121353003801 ABC transporter signature motif; other site 1121353003802 Walker B; other site 1121353003803 D-loop; other site 1121353003804 H-loop/switch region; other site 1121353003805 zinc transporter ZupT; Provisional; Region: PRK04201 1121353003806 ZIP Zinc transporter; Region: Zip; pfam02535 1121353003807 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1121353003808 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1121353003809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 1121353003810 SEC-C motif; Region: SEC-C; pfam02810 1121353003811 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1121353003812 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1121353003813 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1121353003814 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1121353003815 nucleotide binding region [chemical binding]; other site 1121353003816 ATP-binding site [chemical binding]; other site 1121353003817 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1121353003818 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1121353003819 phosphopeptide binding site; other site 1121353003820 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1121353003821 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1121353003822 DNA binding residues [nucleotide binding] 1121353003823 dimer interface [polypeptide binding]; other site 1121353003824 Uncharacterized conserved protein [Function unknown]; Region: COG1259 1121353003825 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1121353003826 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1121353003827 DNA binding residues [nucleotide binding] 1121353003828 putative dimer interface [polypeptide binding]; other site 1121353003829 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1121353003830 metal ion-dependent adhesion site (MIDAS); other site 1121353003831 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1121353003832 Domain of unknown function DUF21; Region: DUF21; pfam01595 1121353003833 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1121353003834 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1121353003835 Domain of unknown function DUF21; Region: DUF21; pfam01595 1121353003836 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1121353003837 Transporter associated domain; Region: CorC_HlyC; smart01091 1121353003838 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1121353003839 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1121353003840 ATP binding site [chemical binding]; other site 1121353003841 putative Mg++ binding site [ion binding]; other site 1121353003842 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121353003843 nucleotide binding region [chemical binding]; other site 1121353003844 ATP-binding site [chemical binding]; other site 1121353003845 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1121353003846 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1121353003847 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1121353003848 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1121353003849 CoenzymeA binding site [chemical binding]; other site 1121353003850 subunit interaction site [polypeptide binding]; other site 1121353003851 PHB binding site; other site 1121353003852 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121353003853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121353003854 S-adenosylmethionine binding site [chemical binding]; other site 1121353003855 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121353003856 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1121353003857 Walker A/P-loop; other site 1121353003858 ATP binding site [chemical binding]; other site 1121353003859 Q-loop/lid; other site 1121353003860 ABC transporter signature motif; other site 1121353003861 Walker B; other site 1121353003862 D-loop; other site 1121353003863 H-loop/switch region; other site 1121353003864 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1121353003865 multifunctional thiamine-phosphate pyrophosphorylase/synthase/phosphomethylpyrimidine kinase; Provisional; Region: PRK09517 1121353003866 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1121353003867 thiamine phosphate binding site [chemical binding]; other site 1121353003868 active site 1121353003869 pyrophosphate binding site [ion binding]; other site 1121353003870 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1121353003871 dimer interface [polypeptide binding]; other site 1121353003872 substrate binding site [chemical binding]; other site 1121353003873 ATP binding site [chemical binding]; other site 1121353003874 Putative transcription activator [Transcription]; Region: TenA; COG0819 1121353003875 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1121353003876 substrate binding site [chemical binding]; other site 1121353003877 multimerization interface [polypeptide binding]; other site 1121353003878 ATP binding site [chemical binding]; other site 1121353003879 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1121353003880 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121353003881 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121353003882 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1121353003883 metabolite-proton symporter; Region: 2A0106; TIGR00883 1121353003884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353003885 putative substrate translocation pore; other site 1121353003886 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1121353003887 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121353003888 active site 1121353003889 Predicted membrane protein [Function unknown]; Region: COG1971 1121353003890 Domain of unknown function DUF; Region: DUF204; pfam02659 1121353003891 Domain of unknown function DUF; Region: DUF204; pfam02659 1121353003892 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1121353003893 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1121353003894 active site 1121353003895 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1121353003896 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1121353003897 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1121353003898 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1121353003899 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1121353003900 YceI-like domain; Region: YceI; pfam04264 1121353003901 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1121353003902 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1121353003903 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1121353003904 Ligand binding site; other site 1121353003905 Putative Catalytic site; other site 1121353003906 DXD motif; other site 1121353003907 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 1121353003908 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1121353003909 putative active site [active] 1121353003910 catalytic triad [active] 1121353003911 putative dimer interface [polypeptide binding]; other site 1121353003912 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1121353003913 Secretory lipase; Region: LIP; pfam03583 1121353003914 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1121353003915 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1121353003916 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1121353003917 active site 1121353003918 putative homodimer interface [polypeptide binding]; other site 1121353003919 SAM binding site [chemical binding]; other site 1121353003920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1121353003921 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1121353003922 classical (c) SDRs; Region: SDR_c; cd05233 1121353003923 NAD(P) binding site [chemical binding]; other site 1121353003924 active site 1121353003925 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1121353003926 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1121353003927 active site 1121353003928 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1121353003929 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1121353003930 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121353003931 ATP binding site [chemical binding]; other site 1121353003932 putative Mg++ binding site [ion binding]; other site 1121353003933 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121353003934 nucleotide binding region [chemical binding]; other site 1121353003935 ATP-binding site [chemical binding]; other site 1121353003936 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1121353003937 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1121353003938 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 1121353003939 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1121353003940 Predicted transcriptional regulator [Transcription]; Region: COG2378 1121353003941 WYL domain; Region: WYL; pfam13280 1121353003942 Predicted transcriptional regulator [Transcription]; Region: COG2378 1121353003943 WYL domain; Region: WYL; pfam13280 1121353003944 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1121353003945 Pup-like protein; Region: Pup; pfam05639 1121353003946 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1121353003947 proteasome ATPase; Region: pup_AAA; TIGR03689 1121353003948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121353003949 Walker A motif; other site 1121353003950 ATP binding site [chemical binding]; other site 1121353003951 Walker B motif; other site 1121353003952 arginine finger; other site 1121353003953 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1121353003954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121353003955 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1121353003956 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1121353003957 active site 1121353003958 metal binding site [ion binding]; metal-binding site 1121353003959 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1121353003960 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1121353003961 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121353003962 non-specific DNA binding site [nucleotide binding]; other site 1121353003963 salt bridge; other site 1121353003964 sequence-specific DNA binding site [nucleotide binding]; other site 1121353003965 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121353003966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353003967 putative substrate translocation pore; other site 1121353003968 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1121353003969 MarR family; Region: MarR_2; pfam12802 1121353003970 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1121353003971 Aspartase; Region: Aspartase; cd01357 1121353003972 active sites [active] 1121353003973 tetramer interface [polypeptide binding]; other site 1121353003974 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1121353003975 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1121353003976 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1121353003977 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1121353003978 homodimer interface [polypeptide binding]; other site 1121353003979 putative metal binding site [ion binding]; other site 1121353003980 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1121353003981 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121353003982 motif II; other site 1121353003983 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1121353003984 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1121353003985 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1121353003986 substrate binding pocket [chemical binding]; other site 1121353003987 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1121353003988 B12 binding site [chemical binding]; other site 1121353003989 cobalt ligand [ion binding]; other site 1121353003990 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1121353003991 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 1121353003992 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121353003993 active site 1121353003994 HIGH motif; other site 1121353003995 nucleotide binding site [chemical binding]; other site 1121353003996 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121353003997 active site 1121353003998 KMSKS motif; other site 1121353003999 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1121353004000 tRNA binding surface [nucleotide binding]; other site 1121353004001 anticodon binding site; other site 1121353004002 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1121353004003 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121353004004 active site 1121353004005 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1121353004006 catalytic tetrad [active] 1121353004007 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1121353004008 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1121353004009 quinone interaction residues [chemical binding]; other site 1121353004010 active site 1121353004011 catalytic residues [active] 1121353004012 FMN binding site [chemical binding]; other site 1121353004013 substrate binding site [chemical binding]; other site 1121353004014 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1121353004015 substrate binding site [chemical binding]; other site 1121353004016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121353004017 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1121353004018 Coenzyme A binding pocket [chemical binding]; other site 1121353004019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1121353004020 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1121353004021 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1121353004022 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1121353004023 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1121353004024 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1121353004025 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1121353004026 ferrochelatase; Reviewed; Region: hemH; PRK00035 1121353004027 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1121353004028 C-terminal domain interface [polypeptide binding]; other site 1121353004029 active site 1121353004030 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1121353004031 active site 1121353004032 N-terminal domain interface [polypeptide binding]; other site 1121353004033 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1121353004034 NlpC/P60 family; Region: NLPC_P60; pfam00877 1121353004035 potential frameshift: common BLAST hit: gi|145295671|ref|YP_001138492.1| aconitate hydratase 1121353004036 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121353004037 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121353004038 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1121353004039 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1121353004040 catalytic triad [active] 1121353004041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121353004042 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1121353004043 NAD(P) binding site [chemical binding]; other site 1121353004044 active site 1121353004045 hypothetical protein; Validated; Region: PRK00194 1121353004046 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1121353004047 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 1121353004048 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121353004049 non-specific DNA binding site [nucleotide binding]; other site 1121353004050 salt bridge; other site 1121353004051 sequence-specific DNA binding site [nucleotide binding]; other site 1121353004052 TIGR04255 family protein; Region: sporadTIGR04255 1121353004053 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1121353004054 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1121353004055 amidase catalytic site [active] 1121353004056 Zn binding residues [ion binding]; other site 1121353004057 substrate binding site [chemical binding]; other site 1121353004058 Protein of unknown function (DUF2744); Region: DUF2744; pfam10910 1121353004059 tape measure domain; Region: tape_meas_nterm; TIGR02675 1121353004060 Protein of unknown function (DUF3417); Region: DUF3417; pfam11897 1121353004061 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1121353004062 Protein of unknown function (DUF1320); Region: DUF1320; cl01818 1121353004063 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1121353004064 Protein of unknown function (DUF917); Region: DUF917; cl17829 1121353004065 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1121353004066 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1121353004067 active site 1121353004068 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1121353004069 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121353004070 ATP binding site [chemical binding]; other site 1121353004071 putative Mg++ binding site [ion binding]; other site 1121353004072 VRR-NUC domain; Region: VRR_NUC; pfam08774 1121353004073 Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545 1121353004074 Virulence-associated protein E; Region: VirE; pfam05272 1121353004075 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 1121353004076 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 1121353004077 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1121353004078 Domain of unknown function (DUF955); Region: DUF955; cl01076 1121353004079 Eps15 homology domain; Region: EH; smart00027 1121353004080 Short C-terminal domain; Region: SHOCT; pfam09851 1121353004081 integrase; Provisional; Region: int; PHA02601 1121353004082 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121353004083 active site 1121353004084 DNA binding site [nucleotide binding] 1121353004085 Int/Topo IB signature motif; other site 1121353004086 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1121353004087 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353004088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353004089 Walker A/P-loop; other site 1121353004090 Walker A/P-loop; other site 1121353004091 ATP binding site [chemical binding]; other site 1121353004092 ATP binding site [chemical binding]; other site 1121353004093 Q-loop/lid; other site 1121353004094 Q-loop/lid; other site 1121353004095 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121353004096 ABC transporter signature motif; other site 1121353004097 Walker B; other site 1121353004098 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121353004099 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1121353004100 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1121353004101 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1121353004102 trimerization site [polypeptide binding]; other site 1121353004103 active site 1121353004104 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1121353004105 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1121353004106 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121353004107 catalytic residue [active] 1121353004108 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1121353004109 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1121353004110 Walker A/P-loop; other site 1121353004111 ATP binding site [chemical binding]; other site 1121353004112 Q-loop/lid; other site 1121353004113 ABC transporter signature motif; other site 1121353004114 Walker B; other site 1121353004115 D-loop; other site 1121353004116 H-loop/switch region; other site 1121353004117 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1121353004118 FeS assembly protein SufD; Region: sufD; TIGR01981 1121353004119 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1121353004120 FeS assembly protein SufB; Region: sufB; TIGR01980 1121353004121 Predicted transcriptional regulator [Transcription]; Region: COG2345 1121353004122 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121353004123 putative DNA binding site [nucleotide binding]; other site 1121353004124 putative Zn2+ binding site [ion binding]; other site 1121353004125 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1121353004126 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1121353004127 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1121353004128 Walker A/P-loop; other site 1121353004129 ATP binding site [chemical binding]; other site 1121353004130 Q-loop/lid; other site 1121353004131 ABC transporter signature motif; other site 1121353004132 Walker B; other site 1121353004133 D-loop; other site 1121353004134 H-loop/switch region; other site 1121353004135 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1121353004136 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1121353004137 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1121353004138 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1121353004139 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1121353004140 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1121353004141 NADP binding site [chemical binding]; other site 1121353004142 dimer interface [polypeptide binding]; other site 1121353004143 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1121353004144 UbiA prenyltransferase family; Region: UbiA; pfam01040 1121353004145 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1121353004146 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1121353004147 TPP-binding site [chemical binding]; other site 1121353004148 dimer interface [polypeptide binding]; other site 1121353004149 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1121353004150 PYR/PP interface [polypeptide binding]; other site 1121353004151 dimer interface [polypeptide binding]; other site 1121353004152 TPP binding site [chemical binding]; other site 1121353004153 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121353004154 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1121353004155 putative active site [active] 1121353004156 transaldolase; Provisional; Region: PRK03903 1121353004157 catalytic residue [active] 1121353004158 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1121353004159 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1121353004160 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1121353004161 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1121353004162 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 1121353004163 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1121353004164 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1121353004165 putative active site [active] 1121353004166 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1121353004167 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1121353004168 ornithine cyclodeaminase; Validated; Region: PRK06199 1121353004169 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 1121353004170 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1121353004171 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1121353004172 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1121353004173 triosephosphate isomerase; Provisional; Region: PRK14567 1121353004174 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1121353004175 substrate binding site [chemical binding]; other site 1121353004176 dimer interface [polypeptide binding]; other site 1121353004177 catalytic triad [active] 1121353004178 Phosphoglycerate kinase; Region: PGK; pfam00162 1121353004179 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1121353004180 substrate binding site [chemical binding]; other site 1121353004181 hinge regions; other site 1121353004182 ADP binding site [chemical binding]; other site 1121353004183 catalytic site [active] 1121353004184 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1121353004185 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1121353004186 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1121353004187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1121353004188 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1121353004189 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1121353004190 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1121353004191 phosphate binding site [ion binding]; other site 1121353004192 putative substrate binding pocket [chemical binding]; other site 1121353004193 dimer interface [polypeptide binding]; other site 1121353004194 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1121353004195 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1121353004196 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1121353004197 GIY-YIG motif/motif A; other site 1121353004198 active site 1121353004199 catalytic site [active] 1121353004200 putative DNA binding site [nucleotide binding]; other site 1121353004201 metal binding site [ion binding]; metal-binding site 1121353004202 UvrB/uvrC motif; Region: UVR; pfam02151 1121353004203 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1121353004204 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1121353004205 minor groove reading motif; other site 1121353004206 helix-hairpin-helix signature motif; other site 1121353004207 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1121353004208 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1121353004209 homopentamer interface [polypeptide binding]; other site 1121353004210 active site 1121353004211 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1121353004212 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1121353004213 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1121353004214 dimerization interface [polypeptide binding]; other site 1121353004215 active site 1121353004216 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1121353004217 Lumazine binding domain; Region: Lum_binding; pfam00677 1121353004218 Lumazine binding domain; Region: Lum_binding; pfam00677 1121353004219 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1121353004220 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1121353004221 catalytic motif [active] 1121353004222 Zn binding site [ion binding]; other site 1121353004223 RibD C-terminal domain; Region: RibD_C; pfam01872 1121353004224 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1121353004225 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1121353004226 substrate binding site [chemical binding]; other site 1121353004227 hexamer interface [polypeptide binding]; other site 1121353004228 metal binding site [ion binding]; metal-binding site 1121353004229 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1121353004230 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1121353004231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121353004232 S-adenosylmethionine binding site [chemical binding]; other site 1121353004233 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1121353004234 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1121353004235 putative active site [active] 1121353004236 substrate binding site [chemical binding]; other site 1121353004237 putative cosubstrate binding site; other site 1121353004238 catalytic site [active] 1121353004239 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1121353004240 substrate binding site [chemical binding]; other site 1121353004241 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1121353004242 active site 1121353004243 catalytic residues [active] 1121353004244 metal binding site [ion binding]; metal-binding site 1121353004245 primosome assembly protein PriA; Provisional; Region: PRK14873 1121353004246 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1121353004247 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1121353004248 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1121353004249 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1121353004250 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1121353004251 Flavoprotein; Region: Flavoprotein; pfam02441 1121353004252 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1121353004253 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1121353004254 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1121353004255 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1121353004256 catalytic site [active] 1121353004257 G-X2-G-X-G-K; other site 1121353004258 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1121353004259 active site 1121353004260 dimer interface [polypeptide binding]; other site 1121353004261 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1121353004262 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121353004263 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121353004264 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1121353004265 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121353004266 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121353004267 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1121353004268 IMP binding site; other site 1121353004269 dimer interface [polypeptide binding]; other site 1121353004270 interdomain contacts; other site 1121353004271 partial ornithine binding site; other site 1121353004272 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1121353004273 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1121353004274 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1121353004275 catalytic site [active] 1121353004276 subunit interface [polypeptide binding]; other site 1121353004277 dihydroorotase; Validated; Region: pyrC; PRK09357 1121353004278 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1121353004279 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1121353004280 active site 1121353004281 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1121353004282 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1121353004283 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1121353004284 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1121353004285 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121353004286 active site 1121353004287 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1121353004288 putative hydrophobic ligand binding site [chemical binding]; other site 1121353004289 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1121353004290 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1121353004291 putative NAD(P) binding site [chemical binding]; other site 1121353004292 putative active site [active] 1121353004293 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1121353004294 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1121353004295 putative RNA binding site [nucleotide binding]; other site 1121353004296 elongation factor P; Validated; Region: PRK00529 1121353004297 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1121353004298 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1121353004299 RNA binding site [nucleotide binding]; other site 1121353004300 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1121353004301 RNA binding site [nucleotide binding]; other site 1121353004302 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1121353004303 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1121353004304 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1121353004305 active site 1121353004306 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1121353004307 active site 1121353004308 dimer interface [polypeptide binding]; other site 1121353004309 metal binding site [ion binding]; metal-binding site 1121353004310 shikimate kinase; Reviewed; Region: aroK; PRK00131 1121353004311 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1121353004312 ADP binding site [chemical binding]; other site 1121353004313 magnesium binding site [ion binding]; other site 1121353004314 putative shikimate binding site; other site 1121353004315 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1121353004316 chorismate synthase; Validated; Region: PRK05382 1121353004317 Tetramer interface [polypeptide binding]; other site 1121353004318 active site 1121353004319 FMN-binding site [chemical binding]; other site 1121353004320 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1121353004321 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121353004322 dimerization interface [polypeptide binding]; other site 1121353004323 putative DNA binding site [nucleotide binding]; other site 1121353004324 putative Zn2+ binding site [ion binding]; other site 1121353004325 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1121353004326 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121353004327 ABC-ATPase subunit interface; other site 1121353004328 dimer interface [polypeptide binding]; other site 1121353004329 putative PBP binding regions; other site 1121353004330 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1121353004331 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1121353004332 intersubunit interface [polypeptide binding]; other site 1121353004333 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1121353004334 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1121353004335 Walker A/P-loop; other site 1121353004336 ATP binding site [chemical binding]; other site 1121353004337 Q-loop/lid; other site 1121353004338 ABC transporter signature motif; other site 1121353004339 Walker B; other site 1121353004340 D-loop; other site 1121353004341 H-loop/switch region; other site 1121353004342 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1121353004343 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1121353004344 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1121353004345 shikimate binding site; other site 1121353004346 NAD(P) binding site [chemical binding]; other site 1121353004347 YceG-like family; Region: YceG; pfam02618 1121353004348 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1121353004349 dimerization interface [polypeptide binding]; other site 1121353004350 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1121353004351 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1121353004352 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1121353004353 motif 1; other site 1121353004354 active site 1121353004355 motif 2; other site 1121353004356 motif 3; other site 1121353004357 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1121353004358 DHHA1 domain; Region: DHHA1; pfam02272 1121353004359 recombination factor protein RarA; Reviewed; Region: PRK13342 1121353004360 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1121353004361 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121353004362 Walker A motif; other site 1121353004363 ATP binding site [chemical binding]; other site 1121353004364 Walker B motif; other site 1121353004365 arginine finger; other site 1121353004366 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1121353004367 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1121353004368 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1121353004369 active site 1121353004370 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1121353004371 active site 1121353004372 ATP binding site [chemical binding]; other site 1121353004373 substrate binding site [chemical binding]; other site 1121353004374 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1121353004375 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1121353004376 dimer interface [polypeptide binding]; other site 1121353004377 anticodon binding site; other site 1121353004378 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1121353004379 homodimer interface [polypeptide binding]; other site 1121353004380 motif 1; other site 1121353004381 active site 1121353004382 motif 2; other site 1121353004383 GAD domain; Region: GAD; pfam02938 1121353004384 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1121353004385 active site 1121353004386 motif 3; other site 1121353004387 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1121353004388 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1121353004389 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121353004390 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1121353004391 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121353004392 ATP binding site [chemical binding]; other site 1121353004393 putative Mg++ binding site [ion binding]; other site 1121353004394 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121353004395 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1121353004396 nucleotide binding region [chemical binding]; other site 1121353004397 ATP-binding site [chemical binding]; other site 1121353004398 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1121353004399 Predicted membrane protein [Function unknown]; Region: COG1511 1121353004400 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1121353004401 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1121353004402 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1121353004403 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1121353004404 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1121353004405 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121353004406 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121353004407 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1121353004408 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1121353004409 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1121353004410 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1121353004411 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1121353004412 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1121353004413 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1121353004414 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1121353004415 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1121353004416 dimer interface [polypeptide binding]; other site 1121353004417 motif 1; other site 1121353004418 active site 1121353004419 motif 2; other site 1121353004420 motif 3; other site 1121353004421 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1121353004422 anticodon binding site; other site 1121353004423 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1121353004424 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1121353004425 active site 1121353004426 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1121353004427 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121353004428 Zn2+ binding site [ion binding]; other site 1121353004429 Mg2+ binding site [ion binding]; other site 1121353004430 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1121353004431 synthetase active site [active] 1121353004432 NTP binding site [chemical binding]; other site 1121353004433 metal binding site [ion binding]; metal-binding site 1121353004434 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1121353004435 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1121353004436 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121353004437 active site 1121353004438 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1121353004439 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1121353004440 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1121353004441 Protein export membrane protein; Region: SecD_SecF; pfam02355 1121353004442 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1121353004443 Protein export membrane protein; Region: SecD_SecF; cl14618 1121353004444 Preprotein translocase subunit; Region: YajC; pfam02699 1121353004445 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1121353004446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121353004447 Walker A motif; other site 1121353004448 ATP binding site [chemical binding]; other site 1121353004449 Walker B motif; other site 1121353004450 arginine finger; other site 1121353004451 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1121353004452 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1121353004453 RuvA N terminal domain; Region: RuvA_N; pfam01330 1121353004454 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1121353004455 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1121353004456 active site 1121353004457 putative DNA-binding cleft [nucleotide binding]; other site 1121353004458 dimer interface [polypeptide binding]; other site 1121353004459 hypothetical protein; Validated; Region: PRK00110 1121353004460 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1121353004461 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1121353004462 active site 1121353004463 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1121353004464 catalytic triad [active] 1121353004465 dimer interface [polypeptide binding]; other site 1121353004466 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1121353004467 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121353004468 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121353004469 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1121353004470 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1121353004471 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1121353004472 putative acyl-acceptor binding pocket; other site 1121353004473 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1121353004474 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1121353004475 nucleotide binding site/active site [active] 1121353004476 HIT family signature motif; other site 1121353004477 catalytic residue [active] 1121353004478 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1121353004479 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1121353004480 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1121353004481 active site 1121353004482 dimer interface [polypeptide binding]; other site 1121353004483 motif 1; other site 1121353004484 motif 2; other site 1121353004485 motif 3; other site 1121353004486 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1121353004487 anticodon binding site; other site 1121353004488 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1121353004489 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1121353004490 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1121353004491 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1121353004492 hypothetical protein; Provisional; Region: PRK14059 1121353004493 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1121353004494 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1121353004495 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1121353004496 SelR domain; Region: SelR; pfam01641 1121353004497 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1121353004498 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1121353004499 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1121353004500 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1121353004501 catalytic site [active] 1121353004502 putative active site [active] 1121353004503 putative substrate binding site [chemical binding]; other site 1121353004504 HRDC domain; Region: HRDC; pfam00570 1121353004505 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1121353004506 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1121353004507 TPP-binding site; other site 1121353004508 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1121353004509 PYR/PP interface [polypeptide binding]; other site 1121353004510 dimer interface [polypeptide binding]; other site 1121353004511 TPP binding site [chemical binding]; other site 1121353004512 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121353004513 TRAM domain; Region: TRAM; pfam01938 1121353004514 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1121353004515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121353004516 S-adenosylmethionine binding site [chemical binding]; other site 1121353004517 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1121353004518 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1121353004519 trimer interface [polypeptide binding]; other site 1121353004520 active site 1121353004521 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1121353004522 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1121353004523 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1121353004524 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1121353004525 active site 1121353004526 dimerization interface [polypeptide binding]; other site 1121353004527 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1121353004528 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1121353004529 nucleotide binding site [chemical binding]; other site 1121353004530 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1121353004531 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1121353004532 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121353004533 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1121353004534 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121353004535 DNA binding residues [nucleotide binding] 1121353004536 Predicted membrane protein [Function unknown]; Region: COG2311 1121353004537 Protein of unknown function (DUF418); Region: DUF418; cl12135 1121353004538 Protein of unknown function (DUF418); Region: DUF418; cl12135 1121353004539 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1121353004540 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121353004541 ATP binding site [chemical binding]; other site 1121353004542 putative Mg++ binding site [ion binding]; other site 1121353004543 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1121353004544 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1121353004545 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1121353004546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121353004547 S-adenosylmethionine binding site [chemical binding]; other site 1121353004548 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1121353004549 putative active site [active] 1121353004550 dimerization interface [polypeptide binding]; other site 1121353004551 putative tRNAtyr binding site [nucleotide binding]; other site 1121353004552 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1121353004553 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1121353004554 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121353004555 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1121353004556 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121353004557 DNA binding residues [nucleotide binding] 1121353004558 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1121353004559 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1121353004560 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1121353004561 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1121353004562 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1121353004563 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1121353004564 NAD binding site [chemical binding]; other site 1121353004565 homodimer interface [polypeptide binding]; other site 1121353004566 active site 1121353004567 substrate binding site [chemical binding]; other site 1121353004568 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1121353004569 PAC2 family; Region: PAC2; pfam09754 1121353004570 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121353004571 ATP binding site [chemical binding]; other site 1121353004572 putative Mg++ binding site [ion binding]; other site 1121353004573 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121353004574 nucleotide binding region [chemical binding]; other site 1121353004575 ATP-binding site [chemical binding]; other site 1121353004576 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1121353004577 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121353004578 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1121353004579 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1121353004580 dimerization interface [polypeptide binding]; other site 1121353004581 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1121353004582 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1121353004583 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121353004584 ATP binding site [chemical binding]; other site 1121353004585 putative Mg++ binding site [ion binding]; other site 1121353004586 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121353004587 nucleotide binding region [chemical binding]; other site 1121353004588 ATP-binding site [chemical binding]; other site 1121353004589 Helicase associated domain (HA2); Region: HA2; pfam04408 1121353004590 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1121353004591 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1121353004592 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1121353004593 ATP cone domain; Region: ATP-cone; pfam03477 1121353004594 LexA repressor; Validated; Region: PRK00215 1121353004595 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1121353004596 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1121353004597 Catalytic site [active] 1121353004598 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1121353004599 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1121353004600 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1121353004601 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1121353004602 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1121353004603 substrate binding site [chemical binding]; other site 1121353004604 ATP binding site [chemical binding]; other site 1121353004605 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1121353004606 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1121353004607 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1121353004608 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1121353004609 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1121353004610 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1121353004611 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1121353004612 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1121353004613 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1121353004614 putative substrate binding site [chemical binding]; other site 1121353004615 putative ATP binding site [chemical binding]; other site 1121353004616 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1121353004617 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1121353004618 active site 1121353004619 phosphorylation site [posttranslational modification] 1121353004620 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1121353004621 active site 1121353004622 P-loop; other site 1121353004623 phosphorylation site [posttranslational modification] 1121353004624 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1121353004625 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1121353004626 dimerization domain swap beta strand [polypeptide binding]; other site 1121353004627 regulatory protein interface [polypeptide binding]; other site 1121353004628 active site 1121353004629 regulatory phosphorylation site [posttranslational modification]; other site 1121353004630 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1121353004631 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1121353004632 GTPases [General function prediction only]; Region: HflX; COG2262 1121353004633 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1121353004634 HflX GTPase family; Region: HflX; cd01878 1121353004635 G1 box; other site 1121353004636 GTP/Mg2+ binding site [chemical binding]; other site 1121353004637 Switch I region; other site 1121353004638 G2 box; other site 1121353004639 G3 box; other site 1121353004640 Switch II region; other site 1121353004641 G4 box; other site 1121353004642 G5 box; other site 1121353004643 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1121353004644 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1121353004645 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1121353004646 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1121353004647 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1121353004648 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1121353004649 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1121353004650 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1121353004651 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1121353004652 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1121353004653 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1121353004654 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121353004655 FeS/SAM binding site; other site 1121353004656 TRAM domain; Region: TRAM; cl01282 1121353004657 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1121353004658 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1121353004659 Walker A/P-loop; other site 1121353004660 ATP binding site [chemical binding]; other site 1121353004661 Q-loop/lid; other site 1121353004662 ABC transporter signature motif; other site 1121353004663 Walker B; other site 1121353004664 D-loop; other site 1121353004665 H-loop/switch region; other site 1121353004666 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1121353004667 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121353004668 substrate binding pocket [chemical binding]; other site 1121353004669 membrane-bound complex binding site; other site 1121353004670 hinge residues; other site 1121353004671 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1121353004672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353004673 dimer interface [polypeptide binding]; other site 1121353004674 conserved gate region; other site 1121353004675 putative PBP binding loops; other site 1121353004676 ABC-ATPase subunit interface; other site 1121353004677 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1121353004678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353004679 dimer interface [polypeptide binding]; other site 1121353004680 conserved gate region; other site 1121353004681 putative PBP binding loops; other site 1121353004682 ABC-ATPase subunit interface; other site 1121353004683 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1121353004684 recombinase A; Provisional; Region: recA; PRK09354 1121353004685 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1121353004686 hexamer interface [polypeptide binding]; other site 1121353004687 Walker A motif; other site 1121353004688 ATP binding site [chemical binding]; other site 1121353004689 Walker B motif; other site 1121353004690 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1121353004691 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1121353004692 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1121353004693 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1121353004694 Walker A/P-loop; other site 1121353004695 ATP binding site [chemical binding]; other site 1121353004696 Q-loop/lid; other site 1121353004697 ABC transporter signature motif; other site 1121353004698 Walker B; other site 1121353004699 D-loop; other site 1121353004700 H-loop/switch region; other site 1121353004701 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1121353004702 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1121353004703 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121353004704 non-specific DNA binding site [nucleotide binding]; other site 1121353004705 salt bridge; other site 1121353004706 sequence-specific DNA binding site [nucleotide binding]; other site 1121353004707 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1121353004708 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1121353004709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 1121353004710 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1121353004711 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1121353004712 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1121353004713 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1121353004714 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1121353004715 TIGR03085 family protein; Region: TIGR03085 1121353004716 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1121353004717 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1121353004718 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121353004719 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1121353004720 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1121353004721 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1121353004722 dimer interface [polypeptide binding]; other site 1121353004723 active site 1121353004724 catalytic residue [active] 1121353004725 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1121353004726 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1121353004727 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1121353004728 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1121353004729 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1121353004730 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1121353004731 oligomer interface [polypeptide binding]; other site 1121353004732 RNA binding site [nucleotide binding]; other site 1121353004733 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1121353004734 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1121353004735 RNase E interface [polypeptide binding]; other site 1121353004736 trimer interface [polypeptide binding]; other site 1121353004737 active site 1121353004738 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1121353004739 putative nucleic acid binding region [nucleotide binding]; other site 1121353004740 G-X-X-G motif; other site 1121353004741 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1121353004742 RNA binding site [nucleotide binding]; other site 1121353004743 domain interface; other site 1121353004744 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1121353004745 16S/18S rRNA binding site [nucleotide binding]; other site 1121353004746 S13e-L30e interaction site [polypeptide binding]; other site 1121353004747 25S rRNA binding site [nucleotide binding]; other site 1121353004748 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1121353004749 active site 1121353004750 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1121353004751 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1121353004752 active site 1121353004753 Riboflavin kinase; Region: Flavokinase; smart00904 1121353004754 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1121353004755 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1121353004756 RNA binding site [nucleotide binding]; other site 1121353004757 active site 1121353004758 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1121353004759 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1121353004760 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1121353004761 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121353004762 putative phosphoesterase; Region: acc_ester; TIGR03729 1121353004763 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1121353004764 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1121353004765 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1121353004766 DHH family; Region: DHH; pfam01368 1121353004767 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1121353004768 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1121353004769 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1121353004770 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1121353004771 G1 box; other site 1121353004772 putative GEF interaction site [polypeptide binding]; other site 1121353004773 GTP/Mg2+ binding site [chemical binding]; other site 1121353004774 Switch I region; other site 1121353004775 G2 box; other site 1121353004776 G3 box; other site 1121353004777 Switch II region; other site 1121353004778 G4 box; other site 1121353004779 G5 box; other site 1121353004780 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1121353004781 Translation-initiation factor 2; Region: IF-2; pfam11987 1121353004782 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1121353004783 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1121353004784 putative RNA binding cleft [nucleotide binding]; other site 1121353004785 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1121353004786 NusA N-terminal domain; Region: NusA_N; pfam08529 1121353004787 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1121353004788 RNA binding site [nucleotide binding]; other site 1121353004789 homodimer interface [polypeptide binding]; other site 1121353004790 NusA-like KH domain; Region: KH_5; pfam13184 1121353004791 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1121353004792 G-X-X-G motif; other site 1121353004793 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1121353004794 Sm and related proteins; Region: Sm_like; cl00259 1121353004795 Sm and related proteins; Region: Sm_like; cl00259 1121353004796 heptamer interface [polypeptide binding]; other site 1121353004797 Sm1 motif; other site 1121353004798 hexamer interface [polypeptide binding]; other site 1121353004799 RNA binding site [nucleotide binding]; other site 1121353004800 Sm2 motif; other site 1121353004801 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1121353004802 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1121353004803 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1121353004804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353004805 dimer interface [polypeptide binding]; other site 1121353004806 conserved gate region; other site 1121353004807 ABC-ATPase subunit interface; other site 1121353004808 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1121353004809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353004810 dimer interface [polypeptide binding]; other site 1121353004811 conserved gate region; other site 1121353004812 putative PBP binding loops; other site 1121353004813 ABC-ATPase subunit interface; other site 1121353004814 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1121353004815 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121353004816 Walker A/P-loop; other site 1121353004817 ATP binding site [chemical binding]; other site 1121353004818 Q-loop/lid; other site 1121353004819 ABC transporter signature motif; other site 1121353004820 Walker B; other site 1121353004821 D-loop; other site 1121353004822 H-loop/switch region; other site 1121353004823 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1121353004824 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121353004825 Walker A/P-loop; other site 1121353004826 ATP binding site [chemical binding]; other site 1121353004827 Q-loop/lid; other site 1121353004828 ABC transporter signature motif; other site 1121353004829 Walker B; other site 1121353004830 D-loop; other site 1121353004831 H-loop/switch region; other site 1121353004832 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1121353004833 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1121353004834 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1121353004835 dimer interface [polypeptide binding]; other site 1121353004836 motif 1; other site 1121353004837 active site 1121353004838 motif 2; other site 1121353004839 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1121353004840 putative deacylase active site [active] 1121353004841 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1121353004842 active site 1121353004843 motif 3; other site 1121353004844 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1121353004845 anticodon binding site; other site 1121353004846 hypothetical protein; Validated; Region: PRK02101 1121353004847 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 1121353004848 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1121353004849 metal ion-dependent adhesion site (MIDAS); other site 1121353004850 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1121353004851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121353004852 Walker A motif; other site 1121353004853 ATP binding site [chemical binding]; other site 1121353004854 Walker B motif; other site 1121353004855 arginine finger; other site 1121353004856 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1121353004857 active site 1121353004858 SAM binding site [chemical binding]; other site 1121353004859 homodimer interface [polypeptide binding]; other site 1121353004860 hypothetical protein; Validated; Region: PRK00029 1121353004861 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1121353004862 malate:quinone oxidoreductase; Validated; Region: PRK05257 1121353004863 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1121353004864 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1121353004865 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1121353004866 mycothione reductase; Reviewed; Region: PRK07846 1121353004867 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121353004868 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1121353004869 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1121353004870 active site 1121353004871 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1121353004872 active site 1121353004873 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1121353004874 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1121353004875 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121353004876 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121353004877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121353004878 active site 1121353004879 phosphorylation site [posttranslational modification] 1121353004880 intermolecular recognition site; other site 1121353004881 dimerization interface [polypeptide binding]; other site 1121353004882 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121353004883 DNA binding residues [nucleotide binding] 1121353004884 dimerization interface [polypeptide binding]; other site 1121353004885 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1121353004886 Histidine kinase; Region: HisKA_3; pfam07730 1121353004887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121353004888 ATP binding site [chemical binding]; other site 1121353004889 Mg2+ binding site [ion binding]; other site 1121353004890 G-X-G motif; other site 1121353004891 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1121353004892 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121353004893 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121353004894 Walker A/P-loop; other site 1121353004895 ATP binding site [chemical binding]; other site 1121353004896 Q-loop/lid; other site 1121353004897 ABC transporter signature motif; other site 1121353004898 Walker B; other site 1121353004899 D-loop; other site 1121353004900 H-loop/switch region; other site 1121353004901 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1121353004902 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1121353004903 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1121353004904 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1121353004905 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1121353004906 active site 1121353004907 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1121353004908 protein binding site [polypeptide binding]; other site 1121353004909 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1121353004910 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1121353004911 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1121353004912 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1121353004913 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1121353004914 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1121353004915 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1121353004916 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121353004917 Walker A/P-loop; other site 1121353004918 ATP binding site [chemical binding]; other site 1121353004919 Q-loop/lid; other site 1121353004920 ABC transporter signature motif; other site 1121353004921 Walker B; other site 1121353004922 D-loop; other site 1121353004923 H-loop/switch region; other site 1121353004924 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1121353004925 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121353004926 FeS/SAM binding site; other site 1121353004927 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1121353004928 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1121353004929 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1121353004930 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1121353004931 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1121353004932 hinge region; other site 1121353004933 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1121353004934 putative nucleotide binding site [chemical binding]; other site 1121353004935 uridine monophosphate binding site [chemical binding]; other site 1121353004936 homohexameric interface [polypeptide binding]; other site 1121353004937 elongation factor Ts; Provisional; Region: tsf; PRK09377 1121353004938 UBA/TS-N domain; Region: UBA; pfam00627 1121353004939 Elongation factor TS; Region: EF_TS; pfam00889 1121353004940 Elongation factor TS; Region: EF_TS; pfam00889 1121353004941 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1121353004942 rRNA interaction site [nucleotide binding]; other site 1121353004943 S8 interaction site; other site 1121353004944 putative laminin-1 binding site; other site 1121353004945 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121353004946 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1121353004947 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121353004948 active site 1121353004949 DNA binding site [nucleotide binding] 1121353004950 Int/Topo IB signature motif; other site 1121353004951 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1121353004952 DNA protecting protein DprA; Region: dprA; TIGR00732 1121353004953 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1121353004954 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1121353004955 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1121353004956 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1121353004957 hypothetical protein; Reviewed; Region: PRK12497 1121353004958 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1121353004959 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1121353004960 RNA/DNA hybrid binding site [nucleotide binding]; other site 1121353004961 active site 1121353004962 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1121353004963 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1121353004964 Catalytic site [active] 1121353004965 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1121353004966 potential frameshift: common BLAST hit: gi|25028487|ref|NP_738541.1| serine protease 1121353004967 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1121353004968 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1121353004969 intersubunit interface [polypeptide binding]; other site 1121353004970 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1121353004971 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1121353004972 active site 1121353004973 pyrophosphate binding site [ion binding]; other site 1121353004974 thiamine phosphate binding site [chemical binding]; other site 1121353004975 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1121353004976 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1121353004977 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1121353004978 thiS-thiF/thiG interaction site; other site 1121353004979 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1121353004980 ThiS interaction site; other site 1121353004981 putative active site [active] 1121353004982 tetramer interface [polypeptide binding]; other site 1121353004983 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 1121353004984 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1121353004985 ATP binding site [chemical binding]; other site 1121353004986 substrate interface [chemical binding]; other site 1121353004987 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121353004988 active site residue [active] 1121353004989 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1121353004990 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1121353004991 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1121353004992 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1121353004993 RNA binding site [nucleotide binding]; other site 1121353004994 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1121353004995 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1121353004996 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1121353004997 RimM N-terminal domain; Region: RimM; pfam01782 1121353004998 PRC-barrel domain; Region: PRC; pfam05239 1121353004999 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1121353005000 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1121353005001 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1121353005002 signal recognition particle protein; Provisional; Region: PRK10867 1121353005003 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1121353005004 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1121353005005 P loop; other site 1121353005006 GTP binding site [chemical binding]; other site 1121353005007 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1121353005008 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 1121353005009 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1121353005010 metal binding triad; other site 1121353005011 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1121353005012 HD domain; Region: HD; pfam01966 1121353005013 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1121353005014 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1121353005015 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1121353005016 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1121353005017 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1121353005018 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121353005019 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1121353005020 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1121353005021 Walker A/P-loop; other site 1121353005022 ATP binding site [chemical binding]; other site 1121353005023 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1121353005024 ABC transporter signature motif; other site 1121353005025 Walker B; other site 1121353005026 D-loop; other site 1121353005027 H-loop/switch region; other site 1121353005028 acylphosphatase; Provisional; Region: PRK14422 1121353005029 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1121353005030 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1121353005031 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1121353005032 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1121353005033 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1121353005034 DNA binding site [nucleotide binding] 1121353005035 catalytic residue [active] 1121353005036 H2TH interface [polypeptide binding]; other site 1121353005037 putative catalytic residues [active] 1121353005038 turnover-facilitating residue; other site 1121353005039 intercalation triad [nucleotide binding]; other site 1121353005040 8OG recognition residue [nucleotide binding]; other site 1121353005041 putative reading head residues; other site 1121353005042 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1121353005043 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1121353005044 ribonuclease III; Reviewed; Region: rnc; PRK00102 1121353005045 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1121353005046 dimerization interface [polypeptide binding]; other site 1121353005047 active site 1121353005048 metal binding site [ion binding]; metal-binding site 1121353005049 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1121353005050 dsRNA binding site [nucleotide binding]; other site 1121353005051 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1121353005052 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1121353005053 glutamate dehydrogenase; Provisional; Region: PRK09414 1121353005054 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1121353005055 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1121353005056 NAD(P) binding site [chemical binding]; other site 1121353005057 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1121353005058 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1121353005059 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1121353005060 metal binding site [ion binding]; metal-binding site 1121353005061 putative dimer interface [polypeptide binding]; other site 1121353005062 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1121353005063 putative homodimer interface [polypeptide binding]; other site 1121353005064 putative active site pocket [active] 1121353005065 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1121353005066 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1121353005067 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1121353005068 putative metal binding site [ion binding]; other site 1121353005069 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1121353005070 active site 1121353005071 pyruvate kinase; Provisional; Region: PRK06247 1121353005072 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1121353005073 domain interfaces; other site 1121353005074 active site 1121353005075 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1121353005076 Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Region: TrpC; COG0134 1121353005077 phosphate binding site [ion binding]; other site 1121353005078 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1121353005079 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1121353005080 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1121353005081 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1121353005082 substrate binding site [chemical binding]; other site 1121353005083 glutamase interaction surface [polypeptide binding]; other site 1121353005084 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1121353005085 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1121353005086 active site 1121353005087 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1121353005088 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1121353005089 catalytic residues [active] 1121353005090 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1121353005091 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1121353005092 putative active site [active] 1121353005093 oxyanion strand; other site 1121353005094 catalytic triad [active] 1121353005095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353005096 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121353005097 putative substrate translocation pore; other site 1121353005098 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1121353005099 putative active site pocket [active] 1121353005100 4-fold oligomerization interface [polypeptide binding]; other site 1121353005101 metal binding residues [ion binding]; metal-binding site 1121353005102 3-fold/trimer interface [polypeptide binding]; other site 1121353005103 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1121353005104 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121353005105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353005106 homodimer interface [polypeptide binding]; other site 1121353005107 catalytic residue [active] 1121353005108 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1121353005109 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1121353005110 NAD binding site [chemical binding]; other site 1121353005111 dimerization interface [polypeptide binding]; other site 1121353005112 product binding site; other site 1121353005113 substrate binding site [chemical binding]; other site 1121353005114 zinc binding site [ion binding]; other site 1121353005115 catalytic residues [active] 1121353005116 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1121353005117 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1121353005118 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121353005119 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1121353005120 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1121353005121 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1121353005122 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1121353005123 active site 1121353005124 catalytic site [active] 1121353005125 Predicted transcriptional regulators [Transcription]; Region: COG1733 1121353005126 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121353005127 dimerization interface [polypeptide binding]; other site 1121353005128 putative DNA binding site [nucleotide binding]; other site 1121353005129 putative Zn2+ binding site [ion binding]; other site 1121353005130 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 1121353005131 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1121353005132 active site 1121353005133 catalytic site [active] 1121353005134 substrate binding site [chemical binding]; other site 1121353005135 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1121353005136 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 1121353005137 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1121353005138 active site 1121353005139 catalytic site [active] 1121353005140 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1121353005141 synthetase active site [active] 1121353005142 NTP binding site [chemical binding]; other site 1121353005143 metal binding site [ion binding]; metal-binding site 1121353005144 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1121353005145 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1121353005146 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121353005147 RNA binding surface [nucleotide binding]; other site 1121353005148 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1121353005149 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1121353005150 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1121353005151 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1121353005152 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1121353005153 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1121353005154 catalytic site [active] 1121353005155 active site 1121353005156 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1121353005157 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121353005158 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121353005159 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1121353005160 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1121353005161 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1121353005162 NAD(P) binding site [chemical binding]; other site 1121353005163 substrate binding site [chemical binding]; other site 1121353005164 dimer interface [polypeptide binding]; other site 1121353005165 threonine dehydratase; Validated; Region: PRK08639 1121353005166 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1121353005167 tetramer interface [polypeptide binding]; other site 1121353005168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353005169 catalytic residue [active] 1121353005170 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1121353005171 putative Ile/Val binding site [chemical binding]; other site 1121353005172 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1121353005173 substrate binding site [chemical binding]; other site 1121353005174 THF binding site; other site 1121353005175 zinc-binding site [ion binding]; other site 1121353005176 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1121353005177 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1121353005178 active site 1121353005179 PHP Thumb interface [polypeptide binding]; other site 1121353005180 metal binding site [ion binding]; metal-binding site 1121353005181 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1121353005182 generic binding surface II; other site 1121353005183 generic binding surface I; other site 1121353005184 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1121353005185 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1121353005186 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1121353005187 active site 1121353005188 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1121353005189 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1121353005190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353005191 Walker A/P-loop; other site 1121353005192 ATP binding site [chemical binding]; other site 1121353005193 Q-loop/lid; other site 1121353005194 ABC transporter signature motif; other site 1121353005195 Walker B; other site 1121353005196 D-loop; other site 1121353005197 H-loop/switch region; other site 1121353005198 ABC transporter; Region: ABC_tran_2; pfam12848 1121353005199 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121353005200 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1121353005201 active site 1121353005202 homotetramer interface [polypeptide binding]; other site 1121353005203 homodimer interface [polypeptide binding]; other site 1121353005204 DNA polymerase IV; Provisional; Region: PRK03348 1121353005205 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1121353005206 active site 1121353005207 DNA binding site [nucleotide binding] 1121353005208 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1121353005209 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1121353005210 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1121353005211 DNA binding residues [nucleotide binding] 1121353005212 putative dimer interface [polypeptide binding]; other site 1121353005213 HEAT repeats; Region: HEAT_2; pfam13646 1121353005214 HEAT repeats; Region: HEAT_2; pfam13646 1121353005215 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1121353005216 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1121353005217 HIGH motif; other site 1121353005218 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1121353005219 active site 1121353005220 KMSKS motif; other site 1121353005221 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1121353005222 tRNA binding surface [nucleotide binding]; other site 1121353005223 anticodon binding site; other site 1121353005224 DivIVA protein; Region: DivIVA; pfam05103 1121353005225 DivIVA domain; Region: DivI1A_domain; TIGR03544 1121353005226 Predicted integral membrane protein [Function unknown]; Region: COG0762 1121353005227 Protein of unknown function (DUF552); Region: DUF552; cl00775 1121353005228 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1121353005229 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121353005230 catalytic residue [active] 1121353005231 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1121353005232 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1121353005233 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1121353005234 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1121353005235 nucleotide binding site [chemical binding]; other site 1121353005236 SulA interaction site; other site 1121353005237 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1121353005238 Cell division protein FtsQ; Region: FtsQ; pfam03799 1121353005239 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1121353005240 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1121353005241 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121353005242 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121353005243 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1121353005244 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1121353005245 active site 1121353005246 homodimer interface [polypeptide binding]; other site 1121353005247 cell division protein FtsW; Region: ftsW; TIGR02614 1121353005248 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 1121353005249 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121353005250 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121353005251 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1121353005252 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1121353005253 Mg++ binding site [ion binding]; other site 1121353005254 putative catalytic motif [active] 1121353005255 putative substrate binding site [chemical binding]; other site 1121353005256 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1121353005257 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1121353005258 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121353005259 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121353005260 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1121353005261 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1121353005262 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121353005263 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121353005264 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1121353005265 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1121353005266 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121353005267 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1121353005268 MraW methylase family; Region: Methyltransf_5; cl17771 1121353005269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1121353005270 MraZ protein; Region: MraZ; pfam02381 1121353005271 MraZ protein; Region: MraZ; pfam02381 1121353005272 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1121353005273 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1121353005274 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1121353005275 Coenzyme A binding pocket [chemical binding]; other site 1121353005276 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1121353005277 FAD binding site [chemical binding]; other site 1121353005278 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1121353005279 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1121353005280 substrate binding pocket [chemical binding]; other site 1121353005281 chain length determination region; other site 1121353005282 substrate-Mg2+ binding site; other site 1121353005283 catalytic residues [active] 1121353005284 aspartate-rich region 1; other site 1121353005285 active site lid residues [active] 1121353005286 aspartate-rich region 2; other site 1121353005287 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1121353005288 Helix-turn-helix domain; Region: HTH_17; cl17695 1121353005289 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1121353005290 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1121353005291 active site 1121353005292 ATP binding site [chemical binding]; other site 1121353005293 substrate binding site [chemical binding]; other site 1121353005294 activation loop (A-loop); other site 1121353005295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1121353005296 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121353005297 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121353005298 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121353005299 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121353005300 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121353005301 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1121353005302 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1121353005303 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1121353005304 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1121353005305 Predicted membrane protein [Function unknown]; Region: COG4763 1121353005306 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1121353005307 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1121353005308 putative acyl-acceptor binding pocket; other site 1121353005309 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1121353005310 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1121353005311 nucleotide binding site [chemical binding]; other site 1121353005312 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121353005313 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121353005314 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1121353005315 NlpC/P60 family; Region: NLPC_P60; pfam00877 1121353005316 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1121353005317 NlpC/P60 family; Region: NLPC_P60; pfam00877 1121353005318 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1121353005319 heme bH binding site [chemical binding]; other site 1121353005320 intrachain domain interface; other site 1121353005321 heme bL binding site [chemical binding]; other site 1121353005322 interchain domain interface [polypeptide binding]; other site 1121353005323 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1121353005324 Qo binding site; other site 1121353005325 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1121353005326 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1121353005327 iron-sulfur cluster [ion binding]; other site 1121353005328 [2Fe-2S] cluster binding site [ion binding]; other site 1121353005329 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1121353005330 Cytochrome c; Region: Cytochrom_C; pfam00034 1121353005331 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1121353005332 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1121353005333 Subunit I/III interface [polypeptide binding]; other site 1121353005334 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1121353005335 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1121353005336 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1121353005337 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1121353005338 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1121353005339 active site 1121353005340 dimer interface [polypeptide binding]; other site 1121353005341 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1121353005342 Ligand Binding Site [chemical binding]; other site 1121353005343 Molecular Tunnel; other site 1121353005344 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1121353005345 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1121353005346 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1121353005347 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1121353005348 putative dimer interface [polypeptide binding]; other site 1121353005349 active site pocket [active] 1121353005350 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1121353005351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121353005352 NAD(P) binding site [chemical binding]; other site 1121353005353 active site 1121353005354 Branched-chain amino acid aminotransferase; Region: DUF3665; pfam12427 1121353005355 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1121353005356 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1121353005357 homodimer interface [polypeptide binding]; other site 1121353005358 substrate-cofactor binding pocket; other site 1121353005359 catalytic residue [active] 1121353005360 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1121353005361 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1121353005362 interface (dimer of trimers) [polypeptide binding]; other site 1121353005363 Substrate-binding/catalytic site; other site 1121353005364 Zn-binding sites [ion binding]; other site 1121353005365 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1121353005366 E3 interaction surface; other site 1121353005367 lipoyl attachment site [posttranslational modification]; other site 1121353005368 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1121353005369 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 1121353005370 E3 interaction surface; other site 1121353005371 lipoyl attachment site [posttranslational modification]; other site 1121353005372 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1121353005373 E3 interaction surface; other site 1121353005374 lipoyl attachment site [posttranslational modification]; other site 1121353005375 e3 binding domain; Region: E3_binding; pfam02817 1121353005376 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1121353005377 lipoate-protein ligase B; Provisional; Region: PRK14345 1121353005378 lipoyl synthase; Provisional; Region: PRK05481 1121353005379 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121353005380 FeS/SAM binding site; other site 1121353005381 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1121353005382 Predicted permease [General function prediction only]; Region: COG2985 1121353005383 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1121353005384 TrkA-C domain; Region: TrkA_C; pfam02080 1121353005385 TrkA-C domain; Region: TrkA_C; pfam02080 1121353005386 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1121353005387 RDD family; Region: RDD; pfam06271 1121353005388 glutamine synthetase, type I; Region: GlnA; TIGR00653 1121353005389 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1121353005390 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1121353005391 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1121353005392 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1121353005393 active site 1121353005394 catalytic triad [active] 1121353005395 oxyanion hole [active] 1121353005396 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1121353005397 nudix motif; other site 1121353005398 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1121353005399 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1121353005400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353005401 catalytic residue [active] 1121353005402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353005403 D-galactonate transporter; Region: 2A0114; TIGR00893 1121353005404 putative substrate translocation pore; other site 1121353005405 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1121353005406 heme binding pocket [chemical binding]; other site 1121353005407 heme ligand [chemical binding]; other site 1121353005408 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1121353005409 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1121353005410 metal binding triad; other site 1121353005411 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1121353005412 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1121353005413 metal binding triad; other site 1121353005414 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1121353005415 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1121353005416 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1121353005417 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1121353005418 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1121353005419 putative active site; other site 1121353005420 putative metal binding residues [ion binding]; other site 1121353005421 signature motif; other site 1121353005422 putative triphosphate binding site [ion binding]; other site 1121353005423 CHAD domain; Region: CHAD; pfam05235 1121353005424 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1121353005425 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1121353005426 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1121353005427 RNB domain; Region: RNB; pfam00773 1121353005428 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1121353005429 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1121353005430 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1121353005431 RNA/DNA hybrid binding site [nucleotide binding]; other site 1121353005432 active site 1121353005433 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121353005434 catalytic core [active] 1121353005435 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1121353005436 Putative zinc ribbon domain; Region: DUF164; pfam02591 1121353005437 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1121353005438 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1121353005439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1121353005440 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1121353005441 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1121353005442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121353005443 motif II; other site 1121353005444 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1121353005445 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1121353005446 active site 1121353005447 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1121353005448 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1121353005449 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1121353005450 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1121353005451 dimer interface [polypeptide binding]; other site 1121353005452 TPP-binding site [chemical binding]; other site 1121353005453 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1121353005454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353005455 Walker A/P-loop; other site 1121353005456 ATP binding site [chemical binding]; other site 1121353005457 Q-loop/lid; other site 1121353005458 ABC transporter signature motif; other site 1121353005459 Walker B; other site 1121353005460 D-loop; other site 1121353005461 H-loop/switch region; other site 1121353005462 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1121353005463 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121353005464 TM-ABC transporter signature motif; other site 1121353005465 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1121353005466 zinc binding site [ion binding]; other site 1121353005467 putative ligand binding site [chemical binding]; other site 1121353005468 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1121353005469 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1121353005470 Serine hydrolase; Region: Ser_hydrolase; cl17834 1121353005471 acyl carrier protein; Provisional; Region: acpP; PRK00982 1121353005472 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1121353005473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121353005474 active site 1121353005475 motif I; other site 1121353005476 motif II; other site 1121353005477 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121353005478 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1121353005479 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1121353005480 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1121353005481 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121353005482 active site 1121353005483 catalytic tetrad [active] 1121353005484 Beta-lactamase; Region: Beta-lactamase; pfam00144 1121353005485 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1121353005486 PhoD-like phosphatase; Region: PhoD; pfam09423 1121353005487 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1121353005488 putative active site [active] 1121353005489 putative metal binding site [ion binding]; other site 1121353005490 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1121353005491 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1121353005492 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1121353005493 DNA primase; Validated; Region: dnaG; PRK05667 1121353005494 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1121353005495 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1121353005496 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1121353005497 active site 1121353005498 metal binding site [ion binding]; metal-binding site 1121353005499 interdomain interaction site; other site 1121353005500 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1121353005501 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1121353005502 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1121353005503 active site 1121353005504 barstar interaction site; other site 1121353005505 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1121353005506 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1121353005507 glutaminase active site [active] 1121353005508 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1121353005509 dimer interface [polypeptide binding]; other site 1121353005510 active site 1121353005511 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1121353005512 dimer interface [polypeptide binding]; other site 1121353005513 active site 1121353005514 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1121353005515 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1121353005516 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121353005517 Zn2+ binding site [ion binding]; other site 1121353005518 Mg2+ binding site [ion binding]; other site 1121353005519 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1121353005520 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1121353005521 putative active site [active] 1121353005522 Repair protein; Region: Repair_PSII; pfam04536 1121353005523 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1121353005524 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1121353005525 motif 1; other site 1121353005526 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1121353005527 active site 1121353005528 motif 2; other site 1121353005529 motif 3; other site 1121353005530 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1121353005531 anticodon binding site; other site 1121353005532 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121353005533 dimerization interface [polypeptide binding]; other site 1121353005534 putative DNA binding site [nucleotide binding]; other site 1121353005535 putative Zn2+ binding site [ion binding]; other site 1121353005536 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1121353005537 metal binding site 2 [ion binding]; metal-binding site 1121353005538 putative DNA binding helix; other site 1121353005539 metal binding site 1 [ion binding]; metal-binding site 1121353005540 dimer interface [polypeptide binding]; other site 1121353005541 structural Zn2+ binding site [ion binding]; other site 1121353005542 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 1121353005543 diiron binding motif [ion binding]; other site 1121353005544 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 1121353005545 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1121353005546 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1121353005547 catalytic residue [active] 1121353005548 putative FPP diphosphate binding site; other site 1121353005549 putative FPP binding hydrophobic cleft; other site 1121353005550 dimer interface [polypeptide binding]; other site 1121353005551 putative IPP diphosphate binding site; other site 1121353005552 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1121353005553 Recombination protein O N terminal; Region: RecO_N; pfam11967 1121353005554 Recombination protein O C terminal; Region: RecO_C; pfam02565 1121353005555 GTPase Era; Reviewed; Region: era; PRK00089 1121353005556 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1121353005557 G1 box; other site 1121353005558 GTP/Mg2+ binding site [chemical binding]; other site 1121353005559 Switch I region; other site 1121353005560 G2 box; other site 1121353005561 Switch II region; other site 1121353005562 G3 box; other site 1121353005563 G4 box; other site 1121353005564 G5 box; other site 1121353005565 KH domain; Region: KH_2; pfam07650 1121353005566 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1121353005567 Domain of unknown function DUF21; Region: DUF21; pfam01595 1121353005568 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1121353005569 Transporter associated domain; Region: CorC_HlyC; smart01091 1121353005570 metal-binding heat shock protein; Provisional; Region: PRK00016 1121353005571 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1121353005572 PhoH-like protein; Region: PhoH; pfam02562 1121353005573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1121353005574 RNA methyltransferase, RsmE family; Region: TIGR00046 1121353005575 chaperone protein DnaJ; Provisional; Region: PRK14278 1121353005576 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1121353005577 HSP70 interaction site [polypeptide binding]; other site 1121353005578 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1121353005579 Zn binding sites [ion binding]; other site 1121353005580 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1121353005581 dimer interface [polypeptide binding]; other site 1121353005582 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1121353005583 HTH domain; Region: HTH_11; cl17392 1121353005584 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121353005585 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1121353005586 FeS/SAM binding site; other site 1121353005587 HemN C-terminal domain; Region: HemN_C; pfam06969 1121353005588 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1121353005589 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1121353005590 acyl-activating enzyme (AAE) consensus motif; other site 1121353005591 putative AMP binding site [chemical binding]; other site 1121353005592 putative active site [active] 1121353005593 putative CoA binding site [chemical binding]; other site 1121353005594 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1121353005595 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1121353005596 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121353005597 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121353005598 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1121353005599 Walker A/P-loop; other site 1121353005600 ATP binding site [chemical binding]; other site 1121353005601 Q-loop/lid; other site 1121353005602 ABC transporter signature motif; other site 1121353005603 Walker B; other site 1121353005604 D-loop; other site 1121353005605 H-loop/switch region; other site 1121353005606 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1121353005607 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1121353005608 active site 1121353005609 Zn binding site [ion binding]; other site 1121353005610 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1121353005611 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1121353005612 substrate binding pocket [chemical binding]; other site 1121353005613 catalytic triad [active] 1121353005614 trehalose synthase; Region: treS_nterm; TIGR02456 1121353005615 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1121353005616 active site 1121353005617 catalytic site [active] 1121353005618 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1121353005619 Phosphotransferase enzyme family; Region: APH; pfam01636 1121353005620 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1121353005621 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1121353005622 active site 1121353005623 metal binding site [ion binding]; metal-binding site 1121353005624 nudix motif; other site 1121353005625 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1121353005626 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121353005627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353005628 homodimer interface [polypeptide binding]; other site 1121353005629 catalytic residue [active] 1121353005630 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1121353005631 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1121353005632 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1121353005633 Predicted permeases [General function prediction only]; Region: COG0679 1121353005634 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1121353005635 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1121353005636 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1121353005637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353005638 dimer interface [polypeptide binding]; other site 1121353005639 conserved gate region; other site 1121353005640 putative PBP binding loops; other site 1121353005641 ABC-ATPase subunit interface; other site 1121353005642 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1121353005643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353005644 dimer interface [polypeptide binding]; other site 1121353005645 conserved gate region; other site 1121353005646 putative PBP binding loops; other site 1121353005647 ABC-ATPase subunit interface; other site 1121353005648 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1121353005649 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121353005650 Walker A/P-loop; other site 1121353005651 ATP binding site [chemical binding]; other site 1121353005652 Q-loop/lid; other site 1121353005653 ABC transporter signature motif; other site 1121353005654 Walker B; other site 1121353005655 D-loop; other site 1121353005656 H-loop/switch region; other site 1121353005657 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1121353005658 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121353005659 Walker A/P-loop; other site 1121353005660 ATP binding site [chemical binding]; other site 1121353005661 Q-loop/lid; other site 1121353005662 ABC transporter signature motif; other site 1121353005663 Walker B; other site 1121353005664 D-loop; other site 1121353005665 H-loop/switch region; other site 1121353005666 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1121353005667 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1121353005668 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1121353005669 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1121353005670 active site 1121353005671 phosphate binding residues; other site 1121353005672 catalytic residues [active] 1121353005673 malate synthase G; Provisional; Region: PRK02999 1121353005674 active site 1121353005675 isocitrate lyase; Provisional; Region: PRK15063 1121353005676 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1121353005677 tetramer interface [polypeptide binding]; other site 1121353005678 active site 1121353005679 Mg2+/Mn2+ binding site [ion binding]; other site 1121353005680 Predicted membrane protein [Function unknown]; Region: COG1289 1121353005681 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1121353005682 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 1121353005683 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121353005684 putative active site [active] 1121353005685 putative metal binding site [ion binding]; other site 1121353005686 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1121353005687 Lamin Tail Domain; Region: LTD; pfam00932 1121353005688 GTP-binding protein LepA; Provisional; Region: PRK05433 1121353005689 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1121353005690 G1 box; other site 1121353005691 putative GEF interaction site [polypeptide binding]; other site 1121353005692 GTP/Mg2+ binding site [chemical binding]; other site 1121353005693 Switch I region; other site 1121353005694 G2 box; other site 1121353005695 G3 box; other site 1121353005696 Switch II region; other site 1121353005697 G4 box; other site 1121353005698 G5 box; other site 1121353005699 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1121353005700 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1121353005701 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1121353005702 PemK-like protein; Region: PemK; pfam02452 1121353005703 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1121353005704 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1121353005705 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1121353005706 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1121353005707 hypothetical protein; Validated; Region: PRK05629 1121353005708 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1121353005709 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1121353005710 Competence protein; Region: Competence; pfam03772 1121353005711 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 1121353005712 SLBB domain; Region: SLBB; pfam10531 1121353005713 Helix-hairpin-helix motif; Region: HHH; pfam00633 1121353005714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1121353005715 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1121353005716 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121353005717 catalytic core [active] 1121353005718 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1121353005719 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1121353005720 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1121353005721 active site 1121353005722 (T/H)XGH motif; other site 1121353005723 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1121353005724 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1121353005725 putative catalytic cysteine [active] 1121353005726 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 1121353005727 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1121353005728 putative ligand binding site [chemical binding]; other site 1121353005729 putative NAD binding site [chemical binding]; other site 1121353005730 catalytic site [active] 1121353005731 gamma-glutamyl kinase; Provisional; Region: PRK05429 1121353005732 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1121353005733 nucleotide binding site [chemical binding]; other site 1121353005734 homotetrameric interface [polypeptide binding]; other site 1121353005735 putative phosphate binding site [ion binding]; other site 1121353005736 putative allosteric binding site; other site 1121353005737 PUA domain; Region: PUA; pfam01472 1121353005738 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1121353005739 GTP1/OBG; Region: GTP1_OBG; pfam01018 1121353005740 Obg GTPase; Region: Obg; cd01898 1121353005741 G1 box; other site 1121353005742 GTP/Mg2+ binding site [chemical binding]; other site 1121353005743 Switch I region; other site 1121353005744 G2 box; other site 1121353005745 G3 box; other site 1121353005746 Switch II region; other site 1121353005747 G4 box; other site 1121353005748 G5 box; other site 1121353005749 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1121353005750 xanthine permease; Region: pbuX; TIGR03173 1121353005751 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 1121353005752 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121353005753 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1121353005754 active site 1121353005755 catalytic tetrad [active] 1121353005756 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1121353005757 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1121353005758 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1121353005759 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1121353005760 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1121353005761 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1121353005762 homodimer interface [polypeptide binding]; other site 1121353005763 oligonucleotide binding site [chemical binding]; other site 1121353005764 Pirin-related protein [General function prediction only]; Region: COG1741 1121353005765 Pirin; Region: Pirin; pfam02678 1121353005766 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1121353005767 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1121353005768 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1121353005769 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1121353005770 active site 1121353005771 multimer interface [polypeptide binding]; other site 1121353005772 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1121353005773 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1121353005774 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1121353005775 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121353005776 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121353005777 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1121353005778 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121353005779 active site 1121353005780 HIGH motif; other site 1121353005781 nucleotide binding site [chemical binding]; other site 1121353005782 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1121353005783 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1121353005784 active site 1121353005785 KMSKS motif; other site 1121353005786 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1121353005787 tRNA binding surface [nucleotide binding]; other site 1121353005788 anticodon binding site; other site 1121353005789 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1121353005790 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1121353005791 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1121353005792 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1121353005793 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 1121353005794 nucleotide binding site [chemical binding]; other site 1121353005795 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1121353005796 SBD interface [polypeptide binding]; other site 1121353005797 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1121353005798 malate dehydrogenase; Provisional; Region: PRK05442 1121353005799 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1121353005800 NAD(P) binding site [chemical binding]; other site 1121353005801 dimer interface [polypeptide binding]; other site 1121353005802 malate binding site [chemical binding]; other site 1121353005803 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121353005804 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121353005805 Predicted permeases [General function prediction only]; Region: COG0679 1121353005806 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1121353005807 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 1121353005808 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121353005809 Walker A motif; other site 1121353005810 ATP binding site [chemical binding]; other site 1121353005811 Walker B motif; other site 1121353005812 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1121353005813 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 1121353005814 active site 1121353005815 catalytic triad [active] 1121353005816 oxyanion hole [active] 1121353005817 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1121353005818 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1121353005819 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1121353005820 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1121353005821 Bacterial transcriptional regulator; Region: IclR; pfam01614 1121353005822 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 1121353005823 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1121353005824 dimer interface [polypeptide binding]; other site 1121353005825 active site 1121353005826 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1121353005827 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121353005828 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121353005829 DNA binding residues [nucleotide binding] 1121353005830 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 1121353005831 3-carboxy-cis,cis-muconate cycloisomerase; Region: protocat_pcaB; TIGR02426 1121353005832 tetramer interface [polypeptide binding]; other site 1121353005833 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1121353005834 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1121353005835 active site 1121353005836 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1121353005837 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1121353005838 active site 1121353005839 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1121353005840 active site 1121353005841 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 1121353005842 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1121353005843 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 1121353005844 metal binding site [ion binding]; metal-binding site 1121353005845 substrate binding pocket [chemical binding]; other site 1121353005846 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 1121353005847 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1121353005848 active site 1121353005849 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1121353005850 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1121353005851 iron-sulfur cluster [ion binding]; other site 1121353005852 [2Fe-2S] cluster binding site [ion binding]; other site 1121353005853 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1121353005854 putative alpha subunit interface [polypeptide binding]; other site 1121353005855 putative active site [active] 1121353005856 putative substrate binding site [chemical binding]; other site 1121353005857 Fe binding site [ion binding]; other site 1121353005858 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1121353005859 inter-subunit interface; other site 1121353005860 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1121353005861 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1121353005862 catalytic loop [active] 1121353005863 iron binding site [ion binding]; other site 1121353005864 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1121353005865 FAD binding pocket [chemical binding]; other site 1121353005866 FAD binding motif [chemical binding]; other site 1121353005867 phosphate binding motif [ion binding]; other site 1121353005868 beta-alpha-beta structure motif; other site 1121353005869 NAD binding pocket [chemical binding]; other site 1121353005870 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1121353005871 FCD domain; Region: FCD; pfam07729 1121353005872 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 1121353005873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121353005874 NAD(P) binding site [chemical binding]; other site 1121353005875 active site 1121353005876 AAA ATPase domain; Region: AAA_16; pfam13191 1121353005877 AAA domain; Region: AAA_22; pfam13401 1121353005878 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121353005879 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121353005880 DNA binding residues [nucleotide binding] 1121353005881 dimerization interface [polypeptide binding]; other site 1121353005882 benzoate transport; Region: 2A0115; TIGR00895 1121353005883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353005884 putative substrate translocation pore; other site 1121353005885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353005886 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1121353005887 benzoate transporter; Region: benE; TIGR00843 1121353005888 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1121353005889 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1121353005890 oligomer interface [polypeptide binding]; other site 1121353005891 active site residues [active] 1121353005892 Clp protease; Region: CLP_protease; pfam00574 1121353005893 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1121353005894 oligomer interface [polypeptide binding]; other site 1121353005895 active site residues [active] 1121353005896 trigger factor; Provisional; Region: tig; PRK01490 1121353005897 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1121353005898 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1121353005899 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1121353005900 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1121353005901 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1121353005902 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1121353005903 catalytic residues [active] 1121353005904 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1121353005905 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1121353005906 Zn binding site [ion binding]; other site 1121353005907 Uncharacterized conserved protein [Function unknown]; Region: COG4748 1121353005908 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1121353005909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121353005910 non-specific DNA binding site [nucleotide binding]; other site 1121353005911 salt bridge; other site 1121353005912 sequence-specific DNA binding site [nucleotide binding]; other site 1121353005913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353005914 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121353005915 putative substrate translocation pore; other site 1121353005916 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 1121353005917 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 1121353005918 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1121353005919 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1121353005920 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121353005921 Walker A/P-loop; other site 1121353005922 ATP binding site [chemical binding]; other site 1121353005923 Q-loop/lid; other site 1121353005924 ABC transporter signature motif; other site 1121353005925 Walker B; other site 1121353005926 D-loop; other site 1121353005927 H-loop/switch region; other site 1121353005928 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121353005929 Walker A/P-loop; other site 1121353005930 ATP binding site [chemical binding]; other site 1121353005931 Q-loop/lid; other site 1121353005932 ABC transporter signature motif; other site 1121353005933 Walker B; other site 1121353005934 D-loop; other site 1121353005935 H-loop/switch region; other site 1121353005936 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1121353005937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353005938 putative PBP binding loops; other site 1121353005939 dimer interface [polypeptide binding]; other site 1121353005940 ABC-ATPase subunit interface; other site 1121353005941 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1121353005942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353005943 dimer interface [polypeptide binding]; other site 1121353005944 conserved gate region; other site 1121353005945 putative PBP binding loops; other site 1121353005946 ABC-ATPase subunit interface; other site 1121353005947 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1121353005948 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1121353005949 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1121353005950 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1121353005951 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1121353005952 short chain dehydrogenase; Provisional; Region: PRK08219 1121353005953 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121353005954 NAD(P) binding site [chemical binding]; other site 1121353005955 active site 1121353005956 potential frameshift: common BLAST hit: gi|62391285|ref|YP_226687.1| TetR family regulatory protein 1121353005957 cystathionine gamma-synthase; Provisional; Region: PRK07811 1121353005958 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1121353005959 homodimer interface [polypeptide binding]; other site 1121353005960 substrate-cofactor binding pocket; other site 1121353005961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353005962 catalytic residue [active] 1121353005963 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1121353005964 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1121353005965 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1121353005966 apolar tunnel; other site 1121353005967 heme binding site [chemical binding]; other site 1121353005968 dimerization interface [polypeptide binding]; other site 1121353005969 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1121353005970 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1121353005971 Chromate transporter; Region: Chromate_transp; pfam02417 1121353005972 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1121353005973 active site 1121353005974 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1121353005975 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353005976 Walker A/P-loop; other site 1121353005977 ATP binding site [chemical binding]; other site 1121353005978 Q-loop/lid; other site 1121353005979 ABC transporter signature motif; other site 1121353005980 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121353005981 ABC transporter; Region: ABC_tran_2; pfam12848 1121353005982 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121353005983 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1121353005984 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1121353005985 dimer interface [polypeptide binding]; other site 1121353005986 ssDNA binding site [nucleotide binding]; other site 1121353005987 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1121353005988 Copper resistance protein D; Region: CopD; pfam05425 1121353005989 Predicted membrane protein [Function unknown]; Region: COG3336 1121353005990 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1121353005991 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353005992 Q-loop/lid; other site 1121353005993 ABC transporter signature motif; other site 1121353005994 Walker B; other site 1121353005995 D-loop; other site 1121353005996 H-loop/switch region; other site 1121353005997 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1121353005998 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121353005999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353006000 dimer interface [polypeptide binding]; other site 1121353006001 conserved gate region; other site 1121353006002 putative PBP binding loops; other site 1121353006003 ABC-ATPase subunit interface; other site 1121353006004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353006005 dimer interface [polypeptide binding]; other site 1121353006006 conserved gate region; other site 1121353006007 putative PBP binding loops; other site 1121353006008 ABC-ATPase subunit interface; other site 1121353006009 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121353006010 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121353006011 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1121353006012 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1121353006013 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1121353006014 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1121353006015 Walker A/P-loop; other site 1121353006016 ATP binding site [chemical binding]; other site 1121353006017 Q-loop/lid; other site 1121353006018 ABC transporter signature motif; other site 1121353006019 Walker B; other site 1121353006020 D-loop; other site 1121353006021 H-loop/switch region; other site 1121353006022 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121353006023 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1121353006024 active site 1121353006025 catalytic residues [active] 1121353006026 DNA binding site [nucleotide binding] 1121353006027 Int/Topo IB signature motif; other site 1121353006028 HTH-like domain; Region: HTH_21; pfam13276 1121353006029 Integrase core domain; Region: rve; pfam00665 1121353006030 Protein of unknown function DUF111; Region: DUF111; cl03398 1121353006031 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1121353006032 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1121353006033 classical (c) SDRs; Region: SDR_c; cd05233 1121353006034 NAD(P) binding site [chemical binding]; other site 1121353006035 active site 1121353006036 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1121353006037 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1121353006038 catalytic site [active] 1121353006039 putative active site [active] 1121353006040 putative substrate binding site [chemical binding]; other site 1121353006041 dimer interface [polypeptide binding]; other site 1121353006042 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1121353006043 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1121353006044 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1121353006045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1121353006046 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1121353006047 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1121353006048 BCCT family transporter; Region: BCCT; cl00569 1121353006049 potential frameshift: common BLAST hit: gi|451943249|ref|YP_007463885.1| high-affinity choline transport protein 1121353006050 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1121353006051 glutaminase; Provisional; Region: PRK00971 1121353006052 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1121353006053 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1121353006054 ATP-binding site [chemical binding]; other site 1121353006055 Gluconate-6-phosphate binding site [chemical binding]; other site 1121353006056 Shikimate kinase; Region: SKI; pfam01202 1121353006057 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1121353006058 Isochorismatase family; Region: Isochorismatase; pfam00857 1121353006059 catalytic triad [active] 1121353006060 metal binding site [ion binding]; metal-binding site 1121353006061 conserved cis-peptide bond; other site 1121353006062 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1121353006063 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1121353006064 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1121353006065 catalytic triad [active] 1121353006066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121353006067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121353006068 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1121353006069 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1121353006070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353006071 putative substrate translocation pore; other site 1121353006072 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1121353006073 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1121353006074 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1121353006075 phosphate binding site [ion binding]; other site 1121353006076 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1121353006077 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1121353006078 active site 2 [active] 1121353006079 active site 1 [active] 1121353006080 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1121353006081 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1121353006082 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1121353006083 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1121353006084 putative NAD(P) binding site [chemical binding]; other site 1121353006085 active site 1121353006086 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1121353006087 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1121353006088 active site 1121353006089 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1121353006090 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121353006091 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1121353006092 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1121353006093 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1121353006094 active site 1121353006095 dimerization interface [polypeptide binding]; other site 1121353006096 ribonuclease PH; Reviewed; Region: rph; PRK00173 1121353006097 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1121353006098 hexamer interface [polypeptide binding]; other site 1121353006099 active site 1121353006100 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1121353006101 glutamate racemase; Provisional; Region: PRK00865 1121353006102 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1121353006103 MarR family; Region: MarR; pfam01047 1121353006104 Rhomboid family; Region: Rhomboid; pfam01694 1121353006105 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1121353006106 putative active site pocket [active] 1121353006107 cleavage site 1121353006108 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1121353006109 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1121353006110 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1121353006111 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1121353006112 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1121353006113 active site 1121353006114 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1121353006115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121353006116 NAD(P) binding site [chemical binding]; other site 1121353006117 active site 1121353006118 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1121353006119 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1121353006120 DEAD_2; Region: DEAD_2; pfam06733 1121353006121 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1121353006122 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1121353006123 Peptidyl-tRNA hydrolase [Translation, ribosomal structure and biogenesis]; Region: pth2; cl17334 1121353006124 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1121353006125 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1121353006126 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1121353006127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121353006128 motif II; other site 1121353006129 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1121353006130 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1121353006131 D-pathway; other site 1121353006132 Putative ubiquinol binding site [chemical binding]; other site 1121353006133 Low-spin heme (heme b) binding site [chemical binding]; other site 1121353006134 Putative water exit pathway; other site 1121353006135 Binuclear center (heme o3/CuB) [ion binding]; other site 1121353006136 K-pathway; other site 1121353006137 Putative proton exit pathway; other site 1121353006138 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1121353006139 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1121353006140 dimer interface [polypeptide binding]; other site 1121353006141 putative radical transfer pathway; other site 1121353006142 diiron center [ion binding]; other site 1121353006143 tyrosyl radical; other site 1121353006144 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1121353006145 Ferritin-like domain; Region: Ferritin; pfam00210 1121353006146 ferroxidase diiron center [ion binding]; other site 1121353006147 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1121353006148 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121353006149 DNA-binding site [nucleotide binding]; DNA binding site 1121353006150 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1121353006151 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1121353006152 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1121353006153 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1121353006154 active site 1121353006155 dimer interface [polypeptide binding]; other site 1121353006156 catalytic residues [active] 1121353006157 effector binding site; other site 1121353006158 R2 peptide binding site; other site 1121353006159 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1121353006160 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1121353006161 catalytic residues [active] 1121353006162 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1121353006163 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1121353006164 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1121353006165 homodimer interface [polypeptide binding]; other site 1121353006166 NAD binding pocket [chemical binding]; other site 1121353006167 ATP binding pocket [chemical binding]; other site 1121353006168 Mg binding site [ion binding]; other site 1121353006169 active-site loop [active] 1121353006170 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1121353006171 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1121353006172 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1121353006173 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1121353006174 NADP binding site [chemical binding]; other site 1121353006175 dimer interface [polypeptide binding]; other site 1121353006176 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1121353006177 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1121353006178 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1121353006179 catalytic residues [active] 1121353006180 phosphoglucomutase; Validated; Region: PRK07564 1121353006181 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1121353006182 active site 1121353006183 substrate binding site [chemical binding]; other site 1121353006184 metal binding site [ion binding]; metal-binding site 1121353006185 CrcB-like protein; Region: CRCB; cl09114 1121353006186 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1121353006187 Predicted membrane protein [General function prediction only]; Region: COG4194 1121353006188 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1121353006189 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1121353006190 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1121353006191 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1121353006192 FtsX-like permease family; Region: FtsX; pfam02687 1121353006193 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121353006194 FtsX-like permease family; Region: FtsX; pfam02687 1121353006195 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121353006196 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121353006197 Walker A/P-loop; other site 1121353006198 ATP binding site [chemical binding]; other site 1121353006199 Q-loop/lid; other site 1121353006200 ABC transporter signature motif; other site 1121353006201 Walker B; other site 1121353006202 D-loop; other site 1121353006203 H-loop/switch region; other site 1121353006204 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1121353006205 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1121353006206 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1121353006207 hinge; other site 1121353006208 active site 1121353006209 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1121353006210 GAF domain; Region: GAF_2; pfam13185 1121353006211 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121353006212 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121353006213 DNA binding residues [nucleotide binding] 1121353006214 dimerization interface [polypeptide binding]; other site 1121353006215 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1121353006216 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1121353006217 dimer interface [polypeptide binding]; other site 1121353006218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353006219 catalytic residue [active] 1121353006220 serine O-acetyltransferase; Region: cysE; TIGR01172 1121353006221 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1121353006222 trimer interface [polypeptide binding]; other site 1121353006223 active site 1121353006224 substrate binding site [chemical binding]; other site 1121353006225 CoA binding site [chemical binding]; other site 1121353006226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121353006227 Coenzyme A binding pocket [chemical binding]; other site 1121353006228 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1121353006229 CoA binding domain; Region: CoA_binding; smart00881 1121353006230 CoA-ligase; Region: Ligase_CoA; pfam00549 1121353006231 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1121353006232 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1121353006233 CoA-ligase; Region: Ligase_CoA; pfam00549 1121353006234 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1121353006235 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1121353006236 catalytic residues [active] 1121353006237 CAAX protease self-immunity; Region: Abi; pfam02517 1121353006238 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1121353006239 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1121353006240 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1121353006241 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1121353006242 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1121353006243 FMN binding site [chemical binding]; other site 1121353006244 active site 1121353006245 catalytic residues [active] 1121353006246 substrate binding site [chemical binding]; other site 1121353006247 Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704 1121353006248 PhoU domain; Region: PhoU; pfam01895 1121353006249 PhoU domain; Region: PhoU; pfam01895 1121353006250 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1121353006251 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1121353006252 Walker A/P-loop; other site 1121353006253 ATP binding site [chemical binding]; other site 1121353006254 Q-loop/lid; other site 1121353006255 ABC transporter signature motif; other site 1121353006256 Walker B; other site 1121353006257 D-loop; other site 1121353006258 H-loop/switch region; other site 1121353006259 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1121353006260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353006261 dimer interface [polypeptide binding]; other site 1121353006262 conserved gate region; other site 1121353006263 putative PBP binding loops; other site 1121353006264 ABC-ATPase subunit interface; other site 1121353006265 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1121353006266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353006267 dimer interface [polypeptide binding]; other site 1121353006268 conserved gate region; other site 1121353006269 putative PBP binding loops; other site 1121353006270 ABC-ATPase subunit interface; other site 1121353006271 PBP superfamily domain; Region: PBP_like_2; cl17296 1121353006272 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1121353006273 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121353006274 Coenzyme A binding pocket [chemical binding]; other site 1121353006275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121353006276 Coenzyme A binding pocket [chemical binding]; other site 1121353006277 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1121353006278 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1121353006279 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1121353006280 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1121353006281 heme-binding site [chemical binding]; other site 1121353006282 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1121353006283 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1121353006284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353006285 catalytic residue [active] 1121353006286 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1121353006287 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1121353006288 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1121353006289 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1121353006290 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1121353006291 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1121353006292 dimerization interface [polypeptide binding]; other site 1121353006293 putative ATP binding site [chemical binding]; other site 1121353006294 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1121353006295 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1121353006296 active site 1121353006297 tetramer interface [polypeptide binding]; other site 1121353006298 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121353006299 active site 1121353006300 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1121353006301 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1121353006302 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1121353006303 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1121353006304 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1121353006305 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1121353006306 dimerization interface [polypeptide binding]; other site 1121353006307 ATP binding site [chemical binding]; other site 1121353006308 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1121353006309 dimerization interface [polypeptide binding]; other site 1121353006310 ATP binding site [chemical binding]; other site 1121353006311 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1121353006312 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1121353006313 putative active site [active] 1121353006314 catalytic triad [active] 1121353006315 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1121353006316 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1121353006317 catalytic residues [active] 1121353006318 dimer interface [polypeptide binding]; other site 1121353006319 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 1121353006320 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1121353006321 generic binding surface II; other site 1121353006322 generic binding surface I; other site 1121353006323 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 1121353006324 putative active site [active] 1121353006325 putative catalytic site [active] 1121353006326 putative Mg binding site IVb [ion binding]; other site 1121353006327 putative phosphate binding site [ion binding]; other site 1121353006328 putative DNA binding site [nucleotide binding]; other site 1121353006329 putative Mg binding site IVa [ion binding]; other site 1121353006330 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1121353006331 putative active site [active] 1121353006332 putative Zn binding site [ion binding]; other site 1121353006333 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1121353006334 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1121353006335 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1121353006336 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1121353006337 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1121353006338 ATP binding site [chemical binding]; other site 1121353006339 active site 1121353006340 substrate binding site [chemical binding]; other site 1121353006341 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1121353006342 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1121353006343 tetramer interface [polypeptide binding]; other site 1121353006344 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1121353006345 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121353006346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353006347 homodimer interface [polypeptide binding]; other site 1121353006348 catalytic residue [active] 1121353006349 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1121353006350 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1121353006351 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1121353006352 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1121353006353 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1121353006354 nucleotide binding site/active site [active] 1121353006355 HIT family signature motif; other site 1121353006356 catalytic residue [active] 1121353006357 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1121353006358 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1121353006359 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121353006360 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121353006361 dimerization interface [polypeptide binding]; other site 1121353006362 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121353006363 dimer interface [polypeptide binding]; other site 1121353006364 phosphorylation site [posttranslational modification] 1121353006365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121353006366 ATP binding site [chemical binding]; other site 1121353006367 Mg2+ binding site [ion binding]; other site 1121353006368 G-X-G motif; other site 1121353006369 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121353006370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121353006371 active site 1121353006372 phosphorylation site [posttranslational modification] 1121353006373 intermolecular recognition site; other site 1121353006374 dimerization interface [polypeptide binding]; other site 1121353006375 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121353006376 DNA binding site [nucleotide binding] 1121353006377 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1121353006378 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1121353006379 DNA binding residues [nucleotide binding] 1121353006380 dimer interface [polypeptide binding]; other site 1121353006381 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1121353006382 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1121353006383 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1121353006384 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121353006385 catalytic residue [active] 1121353006386 pyruvate dehydrogenase; Provisional; Region: PRK06546 1121353006387 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1121353006388 PYR/PP interface [polypeptide binding]; other site 1121353006389 dimer interface [polypeptide binding]; other site 1121353006390 tetramer interface [polypeptide binding]; other site 1121353006391 TPP binding site [chemical binding]; other site 1121353006392 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1121353006393 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1121353006394 TPP-binding site [chemical binding]; other site 1121353006395 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1121353006396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353006397 putative substrate translocation pore; other site 1121353006398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121353006399 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121353006400 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1121353006401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353006402 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1121353006403 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1121353006404 active site 1121353006405 motif I; other site 1121353006406 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1121353006407 Domain of unknown function (DU1801); Region: DUF1801; cl17490 1121353006408 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1121353006409 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 1121353006410 Imelysin; Region: Peptidase_M75; pfam09375 1121353006411 Iron permease FTR1 family; Region: FTR1; cl00475 1121353006412 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1121353006413 non-specific DNA interactions [nucleotide binding]; other site 1121353006414 DNA binding site [nucleotide binding] 1121353006415 sequence specific DNA binding site [nucleotide binding]; other site 1121353006416 putative cAMP binding site [chemical binding]; other site 1121353006417 AAA domain; Region: AAA_25; pfam13481 1121353006418 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121353006419 Walker A motif; other site 1121353006420 ATP binding site [chemical binding]; other site 1121353006421 Walker B motif; other site 1121353006422 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1121353006423 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 1121353006424 Helix-turn-helix domain; Region: HTH_17; pfam12728 1121353006425 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121353006426 active site 1121353006427 DNA binding site [nucleotide binding] 1121353006428 Int/Topo IB signature motif; other site 1121353006429 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1121353006430 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1121353006431 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1121353006432 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1121353006433 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1121353006434 active site 1121353006435 homotetramer interface [polypeptide binding]; other site 1121353006436 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1121353006437 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1121353006438 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121353006439 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121353006440 DNA binding site [nucleotide binding] 1121353006441 domain linker motif; other site 1121353006442 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1121353006443 putative dimerization interface [polypeptide binding]; other site 1121353006444 putative ligand binding site [chemical binding]; other site 1121353006445 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1121353006446 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1121353006447 intersubunit interface [polypeptide binding]; other site 1121353006448 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1121353006449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353006450 Walker A/P-loop; other site 1121353006451 ATP binding site [chemical binding]; other site 1121353006452 Q-loop/lid; other site 1121353006453 ABC transporter signature motif; other site 1121353006454 Walker B; other site 1121353006455 D-loop; other site 1121353006456 H-loop/switch region; other site 1121353006457 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1121353006458 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121353006459 dimer interface [polypeptide binding]; other site 1121353006460 putative PBP binding regions; other site 1121353006461 ABC-ATPase subunit interface; other site 1121353006462 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1121353006463 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1121353006464 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1121353006465 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1121353006466 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121353006467 active site 1121353006468 HIGH motif; other site 1121353006469 nucleotide binding site [chemical binding]; other site 1121353006470 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1121353006471 KMSKS motif; other site 1121353006472 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1121353006473 tRNA binding surface [nucleotide binding]; other site 1121353006474 anticodon binding site; other site 1121353006475 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1121353006476 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1121353006477 active site turn [active] 1121353006478 phosphorylation site [posttranslational modification] 1121353006479 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1121353006480 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1121353006481 HPr interaction site; other site 1121353006482 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1121353006483 active site 1121353006484 phosphorylation site [posttranslational modification] 1121353006485 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 1121353006486 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1121353006487 substrate binding [chemical binding]; other site 1121353006488 active site 1121353006489 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1121353006490 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1121353006491 active site 1121353006492 trimer interface [polypeptide binding]; other site 1121353006493 allosteric site; other site 1121353006494 active site lid [active] 1121353006495 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1121353006496 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1121353006497 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1121353006498 active site 1121353006499 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1121353006500 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1121353006501 inhibitor site; inhibition site 1121353006502 active site 1121353006503 dimer interface [polypeptide binding]; other site 1121353006504 catalytic residue [active] 1121353006505 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1121353006506 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1121353006507 nucleotide binding site [chemical binding]; other site 1121353006508 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1121353006509 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1121353006510 putative active site cavity [active] 1121353006511 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1121353006512 catalytic site [active] 1121353006513 BNR repeat-like domain; Region: BNR_2; pfam13088 1121353006514 Asp-box motif; other site 1121353006515 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1121353006516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121353006517 DNA-binding site [nucleotide binding]; DNA binding site 1121353006518 FCD domain; Region: FCD; pfam07729 1121353006519 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1121353006520 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1121353006521 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1121353006522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353006523 dimer interface [polypeptide binding]; other site 1121353006524 conserved gate region; other site 1121353006525 putative PBP binding loops; other site 1121353006526 ABC-ATPase subunit interface; other site 1121353006527 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1121353006528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353006529 dimer interface [polypeptide binding]; other site 1121353006530 conserved gate region; other site 1121353006531 putative PBP binding loops; other site 1121353006532 ABC-ATPase subunit interface; other site 1121353006533 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1121353006534 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121353006535 Walker A/P-loop; other site 1121353006536 ATP binding site [chemical binding]; other site 1121353006537 Q-loop/lid; other site 1121353006538 ABC transporter signature motif; other site 1121353006539 Walker B; other site 1121353006540 D-loop; other site 1121353006541 H-loop/switch region; other site 1121353006542 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1121353006543 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1121353006544 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121353006545 Walker A/P-loop; other site 1121353006546 ATP binding site [chemical binding]; other site 1121353006547 Q-loop/lid; other site 1121353006548 ABC transporter signature motif; other site 1121353006549 Walker B; other site 1121353006550 D-loop; other site 1121353006551 H-loop/switch region; other site 1121353006552 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1121353006553 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1121353006554 homotrimer interaction site [polypeptide binding]; other site 1121353006555 zinc binding site [ion binding]; other site 1121353006556 CDP-binding sites; other site 1121353006557 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1121353006558 substrate binding site; other site 1121353006559 dimer interface; other site 1121353006560 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1121353006561 DNA repair protein RadA; Provisional; Region: PRK11823 1121353006562 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121353006563 Walker A motif; other site 1121353006564 ATP binding site [chemical binding]; other site 1121353006565 Walker B motif; other site 1121353006566 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1121353006567 Predicted nucleic-acid-binding protein (contains the HHH domain) [General function prediction only]; Region: COG1623 1121353006568 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1121353006569 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1121353006570 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1121353006571 active site clefts [active] 1121353006572 zinc binding site [ion binding]; other site 1121353006573 dimer interface [polypeptide binding]; other site 1121353006574 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1121353006575 endonuclease III; Region: ENDO3c; smart00478 1121353006576 minor groove reading motif; other site 1121353006577 helix-hairpin-helix signature motif; other site 1121353006578 substrate binding pocket [chemical binding]; other site 1121353006579 active site 1121353006580 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1121353006581 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 1121353006582 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1121353006583 Clp amino terminal domain; Region: Clp_N; pfam02861 1121353006584 Clp amino terminal domain; Region: Clp_N; pfam02861 1121353006585 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121353006586 Walker A motif; other site 1121353006587 ATP binding site [chemical binding]; other site 1121353006588 Walker B motif; other site 1121353006589 arginine finger; other site 1121353006590 UvrB/uvrC motif; Region: UVR; pfam02151 1121353006591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121353006592 Walker A motif; other site 1121353006593 ATP binding site [chemical binding]; other site 1121353006594 Walker B motif; other site 1121353006595 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1121353006596 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1121353006597 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 1121353006598 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1121353006599 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1121353006600 active site 1121353006601 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121353006602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353006603 putative substrate translocation pore; other site 1121353006604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353006605 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121353006606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353006607 putative substrate translocation pore; other site 1121353006608 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1121353006609 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1121353006610 dimer interface [polypeptide binding]; other site 1121353006611 putative anticodon binding site; other site 1121353006612 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1121353006613 motif 1; other site 1121353006614 dimer interface [polypeptide binding]; other site 1121353006615 active site 1121353006616 motif 2; other site 1121353006617 motif 3; other site 1121353006618 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121353006619 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1121353006620 active site 1121353006621 nucleotide binding site [chemical binding]; other site 1121353006622 HIGH motif; other site 1121353006623 KMSKS motif; other site 1121353006624 Rossmann-like domain; Region: Rossmann-like; pfam10727 1121353006625 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1121353006626 5' nucleotidase family; Region: 5_nucleotid; cl17687 1121353006627 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1121353006628 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1121353006629 catalytic center binding site [active] 1121353006630 ATP binding site [chemical binding]; other site 1121353006631 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1121353006632 homooctamer interface [polypeptide binding]; other site 1121353006633 active site 1121353006634 dihydropteroate synthase; Region: DHPS; TIGR01496 1121353006635 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1121353006636 substrate binding pocket [chemical binding]; other site 1121353006637 dimer interface [polypeptide binding]; other site 1121353006638 inhibitor binding site; inhibition site 1121353006639 GTP cyclohydrolase I; Provisional; Region: PLN03044 1121353006640 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1121353006641 homodecamer interface [polypeptide binding]; other site 1121353006642 active site 1121353006643 putative catalytic site residues [active] 1121353006644 zinc binding site [ion binding]; other site 1121353006645 GTP-CH-I/GFRP interaction surface; other site 1121353006646 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1121353006647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121353006648 Walker A motif; other site 1121353006649 ATP binding site [chemical binding]; other site 1121353006650 Walker B motif; other site 1121353006651 arginine finger; other site 1121353006652 Peptidase family M41; Region: Peptidase_M41; pfam01434 1121353006653 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121353006654 active site 1121353006655 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1121353006656 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1121353006657 Ligand Binding Site [chemical binding]; other site 1121353006658 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1121353006659 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1121353006660 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1121353006661 dimer interface [polypeptide binding]; other site 1121353006662 substrate binding site [chemical binding]; other site 1121353006663 metal binding sites [ion binding]; metal-binding site 1121353006664 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 1121353006665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121353006666 S-adenosylmethionine binding site [chemical binding]; other site 1121353006667 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1121353006668 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1121353006669 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1121353006670 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1121353006671 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1121353006672 PRD domain; Region: PRD; pfam00874 1121353006673 PRD domain; Region: PRD; pfam00874 1121353006674 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1121353006675 beta-galactosidase; Region: BGL; TIGR03356 1121353006676 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1121353006677 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1121353006678 active site turn [active] 1121353006679 phosphorylation site [posttranslational modification] 1121353006680 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1121353006681 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1121353006682 HPr interaction site; other site 1121353006683 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1121353006684 active site 1121353006685 phosphorylation site [posttranslational modification] 1121353006686 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121353006687 active site residue [active] 1121353006688 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1121353006689 MarR family; Region: MarR; pfam01047 1121353006690 MarR family; Region: MarR_2; cl17246 1121353006691 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 1121353006692 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1121353006693 acyl-activating enzyme (AAE) consensus motif; other site 1121353006694 AMP binding site [chemical binding]; other site 1121353006695 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1121353006696 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1121353006697 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121353006698 putative trimer interface [polypeptide binding]; other site 1121353006699 putative CoA binding site [chemical binding]; other site 1121353006700 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121353006701 putative CoA binding site [chemical binding]; other site 1121353006702 putative trimer interface [polypeptide binding]; other site 1121353006703 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1121353006704 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1121353006705 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1121353006706 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1121353006707 NAD(P) binding site [chemical binding]; other site 1121353006708 catalytic residues [active] 1121353006709 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1121353006710 succinic semialdehyde dehydrogenase; Region: PLN02278 1121353006711 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1121353006712 tetramerization interface [polypeptide binding]; other site 1121353006713 NAD(P) binding site [chemical binding]; other site 1121353006714 catalytic residues [active] 1121353006715 hydroperoxidase II; Provisional; Region: katE; PRK11249 1121353006716 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1121353006717 heme binding pocket [chemical binding]; other site 1121353006718 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1121353006719 domain interactions; other site 1121353006720 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1121353006721 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1121353006722 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1121353006723 ring oligomerisation interface [polypeptide binding]; other site 1121353006724 ATP/Mg binding site [chemical binding]; other site 1121353006725 stacking interactions; other site 1121353006726 hinge regions; other site 1121353006727 Tubulin like; Region: Tubulin_2; pfam13809 1121353006728 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1121353006729 metal ion-dependent adhesion site (MIDAS); other site 1121353006730 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 1121353006731 hypothetical protein; Provisional; Region: PRK07907 1121353006732 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1121353006733 active site 1121353006734 metal binding site [ion binding]; metal-binding site 1121353006735 dimer interface [polypeptide binding]; other site 1121353006736 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 1121353006737 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1121353006738 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1121353006739 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509 1121353006740 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 1121353006741 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 1121353006742 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1121353006743 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1121353006744 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 1121353006745 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12592 1121353006746 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1121353006747 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1121353006748 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1121353006749 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181 1121353006750 carboxylate-amine ligase; Provisional; Region: PRK13517 1121353006751 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1121353006752 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1121353006753 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1121353006754 active site 1121353006755 catalytic residues [active] 1121353006756 metal binding site [ion binding]; metal-binding site 1121353006757 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1121353006758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121353006759 Coenzyme A binding pocket [chemical binding]; other site 1121353006760 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1121353006761 putative catalytic site [active] 1121353006762 putative phosphate binding site [ion binding]; other site 1121353006763 active site 1121353006764 metal binding site A [ion binding]; metal-binding site 1121353006765 DNA binding site [nucleotide binding] 1121353006766 putative AP binding site [nucleotide binding]; other site 1121353006767 putative metal binding site B [ion binding]; other site 1121353006768 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1121353006769 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1121353006770 putative active site [active] 1121353006771 catalytic site [active] 1121353006772 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1121353006773 putative active site [active] 1121353006774 catalytic site [active] 1121353006775 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1121353006776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353006777 putative substrate translocation pore; other site 1121353006778 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1121353006779 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1121353006780 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1121353006781 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1121353006782 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1121353006783 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1121353006784 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1121353006785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353006786 Walker A/P-loop; other site 1121353006787 ATP binding site [chemical binding]; other site 1121353006788 Q-loop/lid; other site 1121353006789 ABC transporter signature motif; other site 1121353006790 Walker B; other site 1121353006791 D-loop; other site 1121353006792 H-loop/switch region; other site 1121353006793 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1121353006794 nudix motif; other site 1121353006795 CHASE3 domain; Region: CHASE3; cl05000 1121353006796 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121353006797 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121353006798 substrate binding pocket [chemical binding]; other site 1121353006799 membrane-bound complex binding site; other site 1121353006800 hinge residues; other site 1121353006801 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1121353006802 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1121353006803 active site 1121353006804 ATP binding site [chemical binding]; other site 1121353006805 substrate binding site [chemical binding]; other site 1121353006806 activation loop (A-loop); other site 1121353006807 propionate/acetate kinase; Provisional; Region: PRK12379 1121353006808 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1121353006809 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1121353006810 ferredoxin-NADP+ reductase; Region: PLN02852 1121353006811 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121353006812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1121353006813 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1121353006814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121353006815 ATP-grasp domain; Region: ATP-grasp; pfam02222 1121353006816 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1121353006817 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1121353006818 GDP-binding site [chemical binding]; other site 1121353006819 ACT binding site; other site 1121353006820 IMP binding site; other site 1121353006821 lipid kinase; Reviewed; Region: PRK13054 1121353006822 Predicted membrane protein [Function unknown]; Region: COG4129 1121353006823 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1121353006824 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1121353006825 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1121353006826 active site 1121353006827 intersubunit interface [polypeptide binding]; other site 1121353006828 zinc binding site [ion binding]; other site 1121353006829 Na+ binding site [ion binding]; other site 1121353006830 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1121353006831 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1121353006832 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1121353006833 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121353006834 active site 1121353006835 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1121353006836 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1121353006837 active site residue [active] 1121353006838 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1121353006839 active site residue [active] 1121353006840 H+ Antiporter protein; Region: 2A0121; TIGR00900 1121353006841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353006842 putative substrate translocation pore; other site 1121353006843 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 1121353006844 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1121353006845 Clp amino terminal domain; Region: Clp_N; pfam02861 1121353006846 Clp amino terminal domain; Region: Clp_N; pfam02861 1121353006847 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121353006848 Walker A motif; other site 1121353006849 ATP binding site [chemical binding]; other site 1121353006850 Walker B motif; other site 1121353006851 arginine finger; other site 1121353006852 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121353006853 Walker A motif; other site 1121353006854 ATP binding site [chemical binding]; other site 1121353006855 Walker B motif; other site 1121353006856 arginine finger; other site 1121353006857 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1121353006858 potential frameshift: common BLAST hit: gi|62391616|ref|YP_227018.1| Na+/glutamate symporter 1121353006859 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1121353006860 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121353006861 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1121353006862 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1121353006863 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1121353006864 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1121353006865 FAD binding pocket [chemical binding]; other site 1121353006866 FAD binding motif [chemical binding]; other site 1121353006867 phosphate binding motif [ion binding]; other site 1121353006868 beta-alpha-beta structure motif; other site 1121353006869 NAD binding pocket [chemical binding]; other site 1121353006870 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1121353006871 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1121353006872 putative active site [active] 1121353006873 catalytic triad [active] 1121353006874 putative dimer interface [polypeptide binding]; other site 1121353006875 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1121353006876 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1121353006877 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1121353006878 NAD(P) binding site [chemical binding]; other site 1121353006879 catalytic residues [active] 1121353006880 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1121353006881 DNA binding residues [nucleotide binding] 1121353006882 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1121353006883 putative dimer interface [polypeptide binding]; other site 1121353006884 chaperone protein DnaJ; Provisional; Region: PRK14279 1121353006885 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1121353006886 HSP70 interaction site [polypeptide binding]; other site 1121353006887 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1121353006888 Zn binding sites [ion binding]; other site 1121353006889 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1121353006890 dimer interface [polypeptide binding]; other site 1121353006891 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1121353006892 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1121353006893 dimer interface [polypeptide binding]; other site 1121353006894 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1121353006895 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1121353006896 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1121353006897 nucleotide binding site [chemical binding]; other site 1121353006898 NEF interaction site [polypeptide binding]; other site 1121353006899 SBD interface [polypeptide binding]; other site 1121353006900 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1121353006901 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1121353006902 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1121353006903 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1121353006904 NAD binding site [chemical binding]; other site 1121353006905 substrate binding site [chemical binding]; other site 1121353006906 catalytic Zn binding site [ion binding]; other site 1121353006907 tetramer interface [polypeptide binding]; other site 1121353006908 structural Zn binding site [ion binding]; other site 1121353006909 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 1121353006910 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1121353006911 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1121353006912 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1121353006913 putative active site [active] 1121353006914 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1121353006915 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1121353006916 CysD dimerization site [polypeptide binding]; other site 1121353006917 G1 box; other site 1121353006918 putative GEF interaction site [polypeptide binding]; other site 1121353006919 GTP/Mg2+ binding site [chemical binding]; other site 1121353006920 Switch I region; other site 1121353006921 G2 box; other site 1121353006922 G3 box; other site 1121353006923 Switch II region; other site 1121353006924 G4 box; other site 1121353006925 G5 box; other site 1121353006926 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1121353006927 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 1121353006928 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1121353006929 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1121353006930 Active Sites [active] 1121353006931 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1121353006932 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1121353006933 Active Sites [active] 1121353006934 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1121353006935 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1121353006936 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1121353006937 ferredoxin-NADP+ reductase; Region: PLN02852 1121353006938 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121353006939 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1121353006940 dimer interface [polypeptide binding]; other site 1121353006941 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1121353006942 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1121353006943 dimer interface [polypeptide binding]; other site 1121353006944 FMN binding site [chemical binding]; other site 1121353006945 NADPH bind site [chemical binding]; other site 1121353006946 Predicted ATPase [General function prediction only]; Region: COG3910 1121353006947 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353006948 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1121353006949 Walker A/P-loop; other site 1121353006950 Walker A/P-loop; other site 1121353006951 ATP binding site [chemical binding]; other site 1121353006952 ATP binding site [chemical binding]; other site 1121353006953 Q-loop/lid; other site 1121353006954 ABC transporter signature motif; other site 1121353006955 Walker B; other site 1121353006956 D-loop; other site 1121353006957 H-loop/switch region; other site 1121353006958 Predicted ATPase [General function prediction only]; Region: COG3910 1121353006959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1121353006960 Walker A/P-loop; other site 1121353006961 ATP binding site [chemical binding]; other site 1121353006962 Q-loop/lid; other site 1121353006963 ABC transporter signature motif; other site 1121353006964 Walker B; other site 1121353006965 D-loop; other site 1121353006966 H-loop/switch region; other site 1121353006967 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121353006968 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1121353006969 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 1121353006970 putative metal binding site [ion binding]; other site 1121353006971 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1121353006972 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1121353006973 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353006974 Walker A/P-loop; other site 1121353006975 ATP binding site [chemical binding]; other site 1121353006976 Q-loop/lid; other site 1121353006977 ABC transporter signature motif; other site 1121353006978 Walker B; other site 1121353006979 D-loop; other site 1121353006980 H-loop/switch region; other site 1121353006981 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353006982 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1121353006983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353006984 Walker A/P-loop; other site 1121353006985 Walker A/P-loop; other site 1121353006986 ATP binding site [chemical binding]; other site 1121353006987 ATP binding site [chemical binding]; other site 1121353006988 Q-loop/lid; other site 1121353006989 ABC transporter signature motif; other site 1121353006990 Walker B; other site 1121353006991 D-loop; other site 1121353006992 H-loop/switch region; other site 1121353006993 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1121353006994 Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Region: URH1; COG1957 1121353006995 active site 1121353006996 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1121353006997 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1121353006998 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1121353006999 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1121353007000 CAT RNA binding domain; Region: CAT_RBD; smart01061 1121353007001 PRD domain; Region: PRD; pfam00874 1121353007002 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1121353007003 potential frameshift: common BLAST hit: gi|237786339|ref|YP_002907044.1| beta-glucoside specific PTS system component 1121353007004 potential frameshift: common BLAST hit: gi|237786339|ref|YP_002907044.1| beta-glucoside specific PTS system component 1121353007005 aminotransferase AlaT; Validated; Region: PRK09265 1121353007006 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121353007007 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353007008 homodimer interface [polypeptide binding]; other site 1121353007009 catalytic residue [active] 1121353007010 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1121353007011 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1121353007012 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1121353007013 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1121353007014 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1121353007015 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1121353007016 trimer interface [polypeptide binding]; other site 1121353007017 active site 1121353007018 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 1121353007019 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1121353007020 VanW like protein; Region: VanW; pfam04294 1121353007021 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1121353007022 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1121353007023 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121353007024 Ligand Binding Site [chemical binding]; other site 1121353007025 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1121353007026 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1121353007027 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1121353007028 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1121353007029 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121353007030 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121353007031 S-adenosylmethionine binding site [chemical binding]; other site 1121353007032 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1121353007033 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1121353007034 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121353007035 sequence-specific DNA binding site [nucleotide binding]; other site 1121353007036 salt bridge; other site 1121353007037 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1121353007038 active site 1121353007039 substrate-binding site [chemical binding]; other site 1121353007040 metal-binding site [ion binding] 1121353007041 GTP binding site [chemical binding]; other site 1121353007042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121353007043 S-adenosylmethionine binding site [chemical binding]; other site 1121353007044 LabA_like proteins; Region: LabA_like; cd06167 1121353007045 putative metal binding site [ion binding]; other site 1121353007046 MMPL family; Region: MMPL; pfam03176 1121353007047 MMPL family; Region: MMPL; pfam03176 1121353007048 Predicted integral membrane protein [Function unknown]; Region: COG0392 1121353007049 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1121353007050 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1121353007051 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1121353007052 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 1121353007053 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1121353007054 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1121353007055 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1121353007056 active site 1121353007057 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 1121353007058 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1121353007059 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1121353007060 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1121353007061 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1121353007062 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1121353007063 acyl-activating enzyme (AAE) consensus motif; other site 1121353007064 active site 1121353007065 Cutinase; Region: Cutinase; pfam01083 1121353007066 Putative esterase; Region: Esterase; pfam00756 1121353007067 S-formylglutathione hydrolase; Region: PLN02442 1121353007068 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1121353007069 LGFP repeat; Region: LGFP; pfam08310 1121353007070 LGFP repeat; Region: LGFP; pfam08310 1121353007071 LGFP repeat; Region: LGFP; pfam08310 1121353007072 Predicted esterase [General function prediction only]; Region: COG0627 1121353007073 S-formylglutathione hydrolase; Region: PLN02442 1121353007074 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1121353007075 UbiA prenyltransferase family; Region: UbiA; pfam01040 1121353007076 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1121353007077 active site 1121353007078 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1121353007079 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1121353007080 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121353007081 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1121353007082 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1121353007083 active site 1121353007084 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1121353007085 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121353007086 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1121353007087 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121353007088 UDP-galactopyranose mutase; Region: GLF; pfam03275 1121353007089 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1121353007090 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1121353007091 amidase catalytic site [active] 1121353007092 Zn binding residues [ion binding]; other site 1121353007093 substrate binding site [chemical binding]; other site 1121353007094 LGFP repeat; Region: LGFP; pfam08310 1121353007095 ApbE family; Region: ApbE; pfam02424 1121353007096 FMN-binding domain; Region: FMN_bind; cl01081 1121353007097 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1121353007098 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1121353007099 FAD binding pocket [chemical binding]; other site 1121353007100 conserved FAD binding motif [chemical binding]; other site 1121353007101 phosphate binding motif [ion binding]; other site 1121353007102 beta-alpha-beta structure motif; other site 1121353007103 NAD binding pocket [chemical binding]; other site 1121353007104 glycerol kinase; Provisional; Region: glpK; PRK00047 1121353007105 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1121353007106 nucleotide binding site [chemical binding]; other site 1121353007107 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121353007108 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1121353007109 active site 1121353007110 motif I; other site 1121353007111 motif II; other site 1121353007112 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121353007113 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1121353007114 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1121353007115 putative acyl-acceptor binding pocket; other site 1121353007116 seryl-tRNA synthetase; Provisional; Region: PRK05431 1121353007117 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1121353007118 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1121353007119 dimer interface [polypeptide binding]; other site 1121353007120 active site 1121353007121 motif 1; other site 1121353007122 motif 2; other site 1121353007123 motif 3; other site 1121353007124 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1121353007125 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121353007126 DNA-binding site [nucleotide binding]; DNA binding site 1121353007127 UTRA domain; Region: UTRA; pfam07702 1121353007128 Septum formation; Region: Septum_form; pfam13845 1121353007129 Septum formation; Region: Septum_form; pfam13845 1121353007130 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1121353007131 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121353007132 catalytic core [active] 1121353007133 prephenate dehydratase; Provisional; Region: PRK11898 1121353007134 Prephenate dehydratase; Region: PDT; pfam00800 1121353007135 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1121353007136 putative L-Phe binding site [chemical binding]; other site 1121353007137 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1121353007138 Amidase; Region: Amidase; cl11426 1121353007139 CAAX protease self-immunity; Region: Abi; pfam02517 1121353007140 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1121353007141 active site 1121353007142 catalytic site [active] 1121353007143 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1121353007144 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 1121353007145 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1121353007146 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1121353007147 putative active site [active] 1121353007148 catalytic site [active] 1121353007149 putative metal binding site [ion binding]; other site 1121353007150 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1121353007151 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121353007152 DNA-binding site [nucleotide binding]; DNA binding site 1121353007153 FCD domain; Region: FCD; pfam07729 1121353007154 potential frameshift: common BLAST hit: gi|308178622|ref|YP_003918028.1| L-asparaginase 1121353007155 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1121353007156 Aspartase; Region: Aspartase; cd01357 1121353007157 active sites [active] 1121353007158 tetramer interface [polypeptide binding]; other site 1121353007159 L-asparagine permease; Provisional; Region: PRK15049 1121353007160 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1121353007161 pyruvate kinase; Provisional; Region: PRK14725 1121353007162 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1121353007163 active site 1121353007164 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1121353007165 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1121353007166 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1121353007167 NAD binding site [chemical binding]; other site 1121353007168 dimer interface [polypeptide binding]; other site 1121353007169 substrate binding site [chemical binding]; other site 1121353007170 Predicted membrane protein [Function unknown]; Region: COG4425 1121353007171 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1121353007172 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1121353007173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1121353007174 motif I; other site 1121353007175 active site 1121353007176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121353007177 motif II; other site 1121353007178 Predicted flavoprotein [General function prediction only]; Region: COG0431 1121353007179 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1121353007180 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1121353007181 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121353007182 DNA-binding site [nucleotide binding]; DNA binding site 1121353007183 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1121353007184 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121353007185 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1121353007186 active site 1121353007187 metal binding site [ion binding]; metal-binding site 1121353007188 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1121353007189 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1121353007190 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1121353007191 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1121353007192 metabolite-proton symporter; Region: 2A0106; TIGR00883 1121353007193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353007194 putative substrate translocation pore; other site 1121353007195 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1121353007196 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1121353007197 active site 1121353007198 substrate binding site [chemical binding]; other site 1121353007199 FMN binding site [chemical binding]; other site 1121353007200 putative catalytic residues [active] 1121353007201 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1121353007202 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1121353007203 metal binding site [ion binding]; metal-binding site 1121353007204 putative dimer interface [polypeptide binding]; other site 1121353007205 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1121353007206 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1121353007207 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1121353007208 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1121353007209 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1121353007210 TrkA-N domain; Region: TrkA_N; pfam02254 1121353007211 TrkA-C domain; Region: TrkA_C; pfam02080 1121353007212 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1121353007213 Cation transport protein; Region: TrkH; pfam02386 1121353007214 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121353007215 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121353007216 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1121353007217 putative dimerization interface [polypeptide binding]; other site 1121353007218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353007219 putative substrate translocation pore; other site 1121353007220 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121353007221 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1121353007222 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1121353007223 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1121353007224 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121353007225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121353007226 active site 1121353007227 phosphorylation site [posttranslational modification] 1121353007228 intermolecular recognition site; other site 1121353007229 dimerization interface [polypeptide binding]; other site 1121353007230 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121353007231 DNA binding residues [nucleotide binding] 1121353007232 dimerization interface [polypeptide binding]; other site 1121353007233 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1121353007234 Histidine kinase; Region: HisKA_3; pfam07730 1121353007235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121353007236 ATP binding site [chemical binding]; other site 1121353007237 Mg2+ binding site [ion binding]; other site 1121353007238 G-X-G motif; other site 1121353007239 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 1121353007240 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1121353007241 active site 1121353007242 catalytic site [active] 1121353007243 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 1121353007244 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1121353007245 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121353007246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121353007247 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1121353007248 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121353007249 Ligand Binding Site [chemical binding]; other site 1121353007250 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121353007251 Ligand Binding Site [chemical binding]; other site 1121353007252 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1121353007253 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1121353007254 probable active site [active] 1121353007255 Integrase core domain; Region: rve; pfam00665 1121353007256 Integrase core domain; Region: rve_3; pfam13683 1121353007257 HTH-like domain; Region: HTH_21; pfam13276 1121353007258 Predicted transcriptional regulators [Transcription]; Region: COG1725 1121353007259 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121353007260 DNA-binding site [nucleotide binding]; DNA binding site 1121353007261 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1121353007262 LabA_like proteins; Region: LabA_like; cd06167 1121353007263 putative metal binding site [ion binding]; other site 1121353007264 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1121353007265 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1121353007266 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1121353007267 catalytic residues [active] 1121353007268 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1121353007269 metal-binding site [ion binding] 1121353007270 benzoate transport; Region: 2A0115; TIGR00895 1121353007271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353007272 putative substrate translocation pore; other site 1121353007273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353007274 Predicted transcriptional regulators [Transcription]; Region: COG1695 1121353007275 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1121353007276 replicative DNA helicase; Provisional; Region: PRK05636 1121353007277 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1121353007278 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1121353007279 Walker A motif; other site 1121353007280 ATP binding site [chemical binding]; other site 1121353007281 Walker B motif; other site 1121353007282 DNA binding loops [nucleotide binding] 1121353007283 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1121353007284 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1121353007285 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1121353007286 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1121353007287 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1121353007288 dimer interface [polypeptide binding]; other site 1121353007289 ssDNA binding site [nucleotide binding]; other site 1121353007290 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1121353007291 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1121353007292 Predicted integral membrane protein [Function unknown]; Region: COG5650 1121353007293 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1121353007294 Transglycosylase; Region: Transgly; pfam00912 1121353007295 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121353007296 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1121353007297 MarR family; Region: MarR; pfam01047 1121353007298 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121353007299 Ligand Binding Site [chemical binding]; other site 1121353007300 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121353007301 Ligand Binding Site [chemical binding]; other site 1121353007302 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1121353007303 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1121353007304 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1121353007305 active site residue [active] 1121353007306 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1121353007307 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1121353007308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 1121353007309 hypothetical protein; Provisional; Region: PRK13663 1121353007310 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1121353007311 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1121353007312 putative DNA binding site [nucleotide binding]; other site 1121353007313 catalytic residue [active] 1121353007314 putative H2TH interface [polypeptide binding]; other site 1121353007315 putative catalytic residues [active] 1121353007316 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1121353007317 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1121353007318 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1121353007319 putative active site [active] 1121353007320 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1121353007321 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1121353007322 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1121353007323 DNA binding site [nucleotide binding] 1121353007324 active site 1121353007325 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1121353007326 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1121353007327 putative NAD(P) binding site [chemical binding]; other site 1121353007328 dimer interface [polypeptide binding]; other site 1121353007329 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1121353007330 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1121353007331 intersubunit interface [polypeptide binding]; other site 1121353007332 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1121353007333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353007334 putative substrate translocation pore; other site 1121353007335 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1121353007336 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1121353007337 N- and C-terminal domain interface [polypeptide binding]; other site 1121353007338 active site 1121353007339 catalytic site [active] 1121353007340 metal binding site [ion binding]; metal-binding site 1121353007341 carbohydrate binding site [chemical binding]; other site 1121353007342 ATP binding site [chemical binding]; other site 1121353007343 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 1121353007344 VanZ like family; Region: VanZ; cl01971 1121353007345 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 1121353007346 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1121353007347 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121353007348 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1121353007349 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1121353007350 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121353007351 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121353007352 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1121353007353 putative FMN binding site [chemical binding]; other site 1121353007354 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1121353007355 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121353007356 active site 1121353007357 HIGH motif; other site 1121353007358 nucleotide binding site [chemical binding]; other site 1121353007359 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1121353007360 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121353007361 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121353007362 active site 1121353007363 KMSKS motif; other site 1121353007364 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1121353007365 tRNA binding surface [nucleotide binding]; other site 1121353007366 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1121353007367 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121353007368 non-specific DNA binding site [nucleotide binding]; other site 1121353007369 salt bridge; other site 1121353007370 sequence-specific DNA binding site [nucleotide binding]; other site 1121353007371 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 1121353007372 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1121353007373 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1121353007374 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1121353007375 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 1121353007376 Cupin domain; Region: Cupin_2; pfam07883 1121353007377 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1121353007378 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1121353007379 Bacterial transcriptional regulator; Region: IclR; pfam01614 1121353007380 benzoate transport; Region: 2A0115; TIGR00895 1121353007381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353007382 putative substrate translocation pore; other site 1121353007383 salicylate hydroxylase; Provisional; Region: PRK08163 1121353007384 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1121353007385 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1121353007386 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1121353007387 SdpI/YhfL protein family; Region: SdpI; pfam13630 1121353007388 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1121353007389 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1121353007390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353007391 dimer interface [polypeptide binding]; other site 1121353007392 conserved gate region; other site 1121353007393 ABC-ATPase subunit interface; other site 1121353007394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121353007395 dimer interface [polypeptide binding]; other site 1121353007396 conserved gate region; other site 1121353007397 ABC-ATPase subunit interface; other site 1121353007398 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1121353007399 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121353007400 Walker A/P-loop; other site 1121353007401 ATP binding site [chemical binding]; other site 1121353007402 Q-loop/lid; other site 1121353007403 ABC transporter signature motif; other site 1121353007404 Walker B; other site 1121353007405 D-loop; other site 1121353007406 H-loop/switch region; other site 1121353007407 anthranilate synthase component I; Provisional; Region: PRK13564 1121353007408 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1121353007409 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1121353007410 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1121353007411 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1121353007412 glutamine binding [chemical binding]; other site 1121353007413 catalytic triad [active] 1121353007414 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1121353007415 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1121353007416 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1121353007417 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1121353007418 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1121353007419 active site 1121353007420 ribulose/triose binding site [chemical binding]; other site 1121353007421 phosphate binding site [ion binding]; other site 1121353007422 substrate (anthranilate) binding pocket [chemical binding]; other site 1121353007423 product (indole) binding pocket [chemical binding]; other site 1121353007424 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1121353007425 active site 1121353007426 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1121353007427 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1121353007428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121353007429 catalytic residue [active] 1121353007430 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1121353007431 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1121353007432 substrate binding site [chemical binding]; other site 1121353007433 active site 1121353007434 catalytic residues [active] 1121353007435 heterodimer interface [polypeptide binding]; other site 1121353007436 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1121353007437 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1121353007438 active site 1121353007439 phosphorylation site [posttranslational modification] 1121353007440 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1121353007441 active site 1121353007442 P-loop; other site 1121353007443 phosphorylation site [posttranslational modification] 1121353007444 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1121353007445 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121353007446 Walker A/P-loop; other site 1121353007447 ATP binding site [chemical binding]; other site 1121353007448 Q-loop/lid; other site 1121353007449 ABC transporter signature motif; other site 1121353007450 Walker B; other site 1121353007451 D-loop; other site 1121353007452 H-loop/switch region; other site 1121353007453 potential frameshift: common BLAST hit: gi|62391887|ref|YP_227289.1| ABC-transporter permease 1121353007454 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1121353007455 iron-sulfur cluster [ion binding]; other site 1121353007456 [2Fe-2S] cluster binding site [ion binding]; other site 1121353007457 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1121353007458 phosphate binding site [ion binding]; other site 1121353007459 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1121353007460 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1121353007461 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 1121353007462 short chain dehydrogenase; Provisional; Region: PRK08267 1121353007463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121353007464 NAD(P) binding site [chemical binding]; other site 1121353007465 active site 1121353007466 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1121353007467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353007468 putative substrate translocation pore; other site 1121353007469 POT family; Region: PTR2; cl17359 1121353007470 Transcriptional regulator; Region: Rrf2; cl17282 1121353007471 Rrf2 family protein; Region: rrf2_super; TIGR00738 1121353007472 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1121353007473 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1121353007474 heme-binding site [chemical binding]; other site 1121353007475 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1121353007476 FAD binding pocket [chemical binding]; other site 1121353007477 conserved FAD binding motif [chemical binding]; other site 1121353007478 phosphate binding motif [ion binding]; other site 1121353007479 beta-alpha-beta structure motif; other site 1121353007480 NAD binding pocket [chemical binding]; other site 1121353007481 Lamin Tail Domain; Region: LTD; pfam00932 1121353007482 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1121353007483 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121353007484 putative active site [active] 1121353007485 putative metal binding site [ion binding]; other site 1121353007486 proline/glycine betaine transporter; Provisional; Region: PRK10642 1121353007487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353007488 putative substrate translocation pore; other site 1121353007489 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1121353007490 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1121353007491 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1121353007492 Integrase core domain; Region: rve; pfam00665 1121353007493 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1121353007494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121353007495 Walker A motif; other site 1121353007496 ATP binding site [chemical binding]; other site 1121353007497 Walker B motif; other site 1121353007498 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 1121353007499 GIY-YIG motif/motif A; other site 1121353007500 active site 1121353007501 catalytic site [active] 1121353007502 Predicted helicase [General function prediction only]; Region: COG4889 1121353007503 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 1121353007504 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121353007505 ATP binding site [chemical binding]; other site 1121353007506 putative Mg++ binding site [ion binding]; other site 1121353007507 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121353007508 ATP-binding site [chemical binding]; other site 1121353007509 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 1121353007510 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1121353007511 substrate binding site [chemical binding]; other site 1121353007512 dimer interface [polypeptide binding]; other site 1121353007513 ATP binding site [chemical binding]; other site 1121353007514 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1121353007515 metal-binding site [ion binding] 1121353007516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121353007517 metabolite-proton symporter; Region: 2A0106; TIGR00883 1121353007518 putative substrate translocation pore; other site 1121353007519 Isochorismatase family; Region: Isochorismatase; pfam00857 1121353007520 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1121353007521 catalytic triad [active] 1121353007522 conserved cis-peptide bond; other site 1121353007523 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1121353007524 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1121353007525 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1121353007526 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1121353007527 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1121353007528 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1121353007529 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1121353007530 Bacterial transcriptional regulator; Region: IclR; pfam01614 1121353007531 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1121353007532 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1121353007533 hypothetical protein; Validated; Region: PRK00228 1121353007534 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1121353007535 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1121353007536 active site 1121353007537 NTP binding site [chemical binding]; other site 1121353007538 metal binding triad [ion binding]; metal-binding site 1121353007539 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1121353007540 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121353007541 Zn2+ binding site [ion binding]; other site 1121353007542 Mg2+ binding site [ion binding]; other site 1121353007543 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1121353007544 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1121353007545 active site 1121353007546 Ap6A binding site [chemical binding]; other site 1121353007547 nudix motif; other site 1121353007548 metal binding site [ion binding]; metal-binding site 1121353007549 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1121353007550 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1121353007551 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1121353007552 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121353007553 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121353007554 DNA binding residues [nucleotide binding] 1121353007555 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1121353007556 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121353007557 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121353007558 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1121353007559 catalytic residues [active] 1121353007560 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1121353007561 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1121353007562 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1121353007563 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1121353007564 active site 1121353007565 metal binding site [ion binding]; metal-binding site 1121353007566 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1121353007567 ParB-like nuclease domain; Region: ParB; smart00470 1121353007568 KorB domain; Region: KorB; pfam08535 1121353007569 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1121353007570 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121353007571 P-loop; other site 1121353007572 Magnesium ion binding site [ion binding]; other site 1121353007573 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121353007574 Magnesium ion binding site [ion binding]; other site 1121353007575 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121353007576 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1121353007577 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1121353007578 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1121353007579 Haemolytic domain; Region: Haemolytic; pfam01809 1121353007580 ribonuclease P; Reviewed; Region: rnpA; PRK03459 1121353007581 Replication protein; Region: Rep_1; cl02412 1121353007582 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121353007583 dimerization interface [polypeptide binding]; other site 1121353007584 putative DNA binding site [nucleotide binding]; other site 1121353007585 putative Zn2+ binding site [ion binding]; other site 1121353007586 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1121353007587 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1121353007588 catalytic residues [active] 1121353007589 catalytic nucleophile [active] 1121353007590 Presynaptic Site I dimer interface [polypeptide binding]; other site 1121353007591 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1121353007592 Synaptic Flat tetramer interface [polypeptide binding]; other site 1121353007593 Synaptic Site I dimer interface [polypeptide binding]; other site 1121353007594 DNA binding site [nucleotide binding] 1121353007595 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1121353007596 DNA-binding interface [nucleotide binding]; DNA binding site 1121353007597 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 1121353007598 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1121353007599 DNA binding residues [nucleotide binding] 1121353007600 dimer interface [polypeptide binding]; other site 1121353007601 metal binding site [ion binding]; metal-binding site 1121353007602 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1121353007603 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1121353007604 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1121353007605 putative active site [active] 1121353007606 redox center [active] 1121353007607 Thioredoxin; Region: Thioredoxin_4; cl17273 1121353007608 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121353007609 dimerization interface [polypeptide binding]; other site 1121353007610 putative DNA binding site [nucleotide binding]; other site 1121353007611 putative Zn2+ binding site [ion binding]; other site 1121353007612 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1121353007613 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121353007614 Copper resistance protein D; Region: CopD; pfam05425 1121353007615 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1121353007616 CopC domain; Region: CopC; pfam04234 1121353007617 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121353007618 dimerization interface [polypeptide binding]; other site 1121353007619 putative DNA binding site [nucleotide binding]; other site 1121353007620 putative Zn2+ binding site [ion binding]; other site 1121353007621 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1121353007622 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121353007623 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1121353007624 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1121353007625 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1121353007626 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121353007627 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1121353007628 Homeodomain-like domain; Region: HTH_23; pfam13384 1121353007629 Winged helix-turn helix; Region: HTH_29; pfam13551 1121353007630 Homeodomain-like domain; Region: HTH_32; pfam13565 1121353007631 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1121353007632 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1121353007633 DDE superfamily endonuclease; Region: DDE_5; cl17874 1121353007634 Integrase core domain; Region: rve_3; pfam13683 1121353007635 HTH-like domain; Region: HTH_21; pfam13276 1121353007636 Integrase core domain; Region: rve; pfam00665 1121353007637 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1121353007638 Helix-turn-helix domain; Region: HTH_38; pfam13936 1121353007639 Integrase core domain; Region: rve; pfam00665 1121353007640 Transposase; Region: HTH_Tnp_1; cl17663 1121353007641 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1121353007642 Part of AAA domain; Region: AAA_19; pfam13245 1121353007643 Family description; Region: UvrD_C_2; pfam13538 1121353007644 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1121353007645 AAA domain; Region: AAA_21; pfam13304 1121353007646 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1121353007647 putative active site [active] 1121353007648 putative metal-binding site [ion binding]; other site 1121353007649 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1121353007650 Integrase core domain; Region: rve; pfam00665 1121353007651 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1121353007652 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1121353007653 Protein of unknown function DUF262; Region: DUF262; pfam03235 1121353007654 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1121353007655 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1121353007656 active site 1121353007657 catalytic site [active] 1121353007658 substrate binding site [chemical binding]; other site 1121353007659 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1121353007660 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121353007661 P-loop; other site 1121353007662 Magnesium ion binding site [ion binding]; other site 1121353007663 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 1121353007664 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1121353007665 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1121353007666 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1121353007667 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1121353007668 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1121353007669 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1121353007670 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1121353007671 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1121353007672 DNA methylase; Region: N6_N4_Mtase; pfam01555 1121353007673 DNA methylase; Region: N6_N4_Mtase; pfam01555 1121353007674 Replicase family; Region: Replicase; pfam03090 1121353007675 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121353007676 sequence-specific DNA binding site [nucleotide binding]; other site 1121353007677 salt bridge; other site 1121353007678 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121353007679 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121353007680 non-specific DNA binding site [nucleotide binding]; other site 1121353007681 salt bridge; other site 1121353007682 sequence-specific DNA binding site [nucleotide binding]; other site 1121353007683 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121353007684 non-specific DNA binding site [nucleotide binding]; other site 1121353007685 salt bridge; other site 1121353007686 sequence-specific DNA binding site [nucleotide binding]; other site 1121353007687 Cutinase; Region: Cutinase; pfam01083 1121353007688 AAA-like domain; Region: AAA_10; pfam12846 1121353007689 rod shape-determining protein MreC; Provisional; Region: PRK13922 1121353007690 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1121353007691 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121353007692 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1121353007693 NlpC/P60 family; Region: NLPC_P60; cl17555 1121353007694 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 1121353007695 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121353007696 Walker A motif; other site 1121353007697 ATP binding site [chemical binding]; other site 1121353007698 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1121353007699 TrwC relaxase; Region: TrwC; pfam08751 1121353007700 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1121353007701 AAA domain; Region: AAA_30; pfam13604 1121353007702 Family description; Region: UvrD_C_2; pfam13538 1121353007703 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1121353007704 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1121353007705 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121353007706 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1121353007707 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 1121353007708 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1121353007709 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1121353007710 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1121353007711 catalytic residues [active] 1121353007712 catalytic nucleophile [active] 1121353007713 Presynaptic Site I dimer interface [polypeptide binding]; other site 1121353007714 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1121353007715 Synaptic Flat tetramer interface [polypeptide binding]; other site 1121353007716 Synaptic Site I dimer interface [polypeptide binding]; other site 1121353007717 DNA binding site [nucleotide binding] 1121353007718 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1121353007719 DNA-binding interface [nucleotide binding]; DNA binding site 1121353007720 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1121353007721 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1121353007722 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1121353007723 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 1121353007724 Cadmium resistance transporter; Region: Cad; pfam03596