-- dump date 20140619_050637 -- class Genbank::misc_feature -- table misc_feature_note -- id note 698966000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 698966000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698966000003 Walker A motif; other site 698966000004 ATP binding site [chemical binding]; other site 698966000005 Walker B motif; other site 698966000006 arginine finger; other site 698966000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 698966000008 DnaA box-binding interface [nucleotide binding]; other site 698966000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 698966000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 698966000011 putative DNA binding surface [nucleotide binding]; other site 698966000012 dimer interface [polypeptide binding]; other site 698966000013 beta-clamp/clamp loader binding surface; other site 698966000014 beta-clamp/translesion DNA polymerase binding surface; other site 698966000015 recombination protein F; Reviewed; Region: recF; PRK00064 698966000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 698966000017 Walker A/P-loop; other site 698966000018 ATP binding site [chemical binding]; other site 698966000019 Q-loop/lid; other site 698966000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966000021 ABC transporter signature motif; other site 698966000022 Walker B; other site 698966000023 D-loop; other site 698966000024 H-loop/switch region; other site 698966000025 hypothetical protein; Provisional; Region: PRK00111 698966000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 698966000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698966000028 ATP binding site [chemical binding]; other site 698966000029 Mg2+ binding site [ion binding]; other site 698966000030 G-X-G motif; other site 698966000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698966000032 anchoring element; other site 698966000033 dimer interface [polypeptide binding]; other site 698966000034 ATP binding site [chemical binding]; other site 698966000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 698966000036 active site 698966000037 putative metal-binding site [ion binding]; other site 698966000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698966000039 DNA gyrase subunit A; Validated; Region: PRK05560 698966000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 698966000041 CAP-like domain; other site 698966000042 active site 698966000043 primary dimer interface [polypeptide binding]; other site 698966000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698966000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698966000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698966000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698966000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698966000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698966000050 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 698966000051 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698966000052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698966000053 DNA-binding site [nucleotide binding]; DNA binding site 698966000054 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698966000055 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698966000056 L-lactate permease; Region: Lactate_perm; cl00701 698966000057 Cadherin repeat-like domain; Region: CA_like; cl15786 698966000058 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698966000059 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698966000060 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 698966000061 Walker A/P-loop; other site 698966000062 ATP binding site [chemical binding]; other site 698966000063 Q-loop/lid; other site 698966000064 ABC transporter signature motif; other site 698966000065 Walker B; other site 698966000066 D-loop; other site 698966000067 H-loop/switch region; other site 698966000068 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698966000069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966000070 Walker A/P-loop; other site 698966000071 ATP binding site [chemical binding]; other site 698966000072 Q-loop/lid; other site 698966000073 ABC transporter signature motif; other site 698966000074 Walker B; other site 698966000075 D-loop; other site 698966000076 H-loop/switch region; other site 698966000077 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698966000078 active site 698966000079 catalytic site [active] 698966000080 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698966000081 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698966000082 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 698966000083 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698966000084 putative ligand binding site [chemical binding]; other site 698966000085 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698966000086 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698966000087 TM-ABC transporter signature motif; other site 698966000088 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698966000089 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698966000090 Walker A/P-loop; other site 698966000091 ATP binding site [chemical binding]; other site 698966000092 Q-loop/lid; other site 698966000093 ABC transporter signature motif; other site 698966000094 Walker B; other site 698966000095 D-loop; other site 698966000096 H-loop/switch region; other site 698966000097 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698966000098 active site 698966000099 Integrase core domain; Region: rve_2; pfam13333 698966000100 Rhomboid family; Region: Rhomboid; pfam01694 698966000101 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 698966000102 ThiC-associated domain; Region: ThiC-associated; pfam13667 698966000103 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 698966000104 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698966000105 thiamine phosphate binding site [chemical binding]; other site 698966000106 active site 698966000107 pyrophosphate binding site [ion binding]; other site 698966000108 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698966000109 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 698966000110 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 698966000111 ThiS interaction site; other site 698966000112 putative active site [active] 698966000113 tetramer interface [polypeptide binding]; other site 698966000114 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 698966000115 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698966000116 ATP binding site [chemical binding]; other site 698966000117 substrate interface [chemical binding]; other site 698966000118 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698966000119 active site residue [active] 698966000120 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 698966000121 dimer interface [polypeptide binding]; other site 698966000122 substrate binding site [chemical binding]; other site 698966000123 ATP binding site [chemical binding]; other site 698966000124 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 698966000125 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 698966000126 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 698966000127 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 698966000128 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 698966000129 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698966000130 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698966000131 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698966000132 MULE transposase domain; Region: MULE; pfam10551 698966000133 putative septation inhibitor protein; Reviewed; Region: PRK00159 698966000134 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698966000135 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698966000136 active site 698966000137 ATP binding site [chemical binding]; other site 698966000138 substrate binding site [chemical binding]; other site 698966000139 activation loop (A-loop); other site 698966000140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698966000141 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698966000142 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698966000143 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698966000144 PASTA domain; Region: PASTA; pfam03793 698966000145 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698966000146 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698966000147 active site 698966000148 ATP binding site [chemical binding]; other site 698966000149 substrate binding site [chemical binding]; other site 698966000150 activation loop (A-loop); other site 698966000151 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698966000152 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698966000153 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698966000154 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 698966000155 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 698966000156 Protein phosphatase 2C; Region: PP2C; pfam00481 698966000157 active site 698966000158 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698966000159 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698966000160 phosphopeptide binding site; other site 698966000161 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 698966000162 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698966000163 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698966000164 phosphopeptide binding site; other site 698966000165 potential frameshift: common BLAST hit: gi|38233952|ref|NP_939719.1| transposase 698966000166 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698966000167 HTH-like domain; Region: HTH_21; pfam13276 698966000168 Integrase core domain; Region: rve; pfam00665 698966000169 Integrase core domain; Region: rve_2; pfam13333 698966000170 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 698966000171 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698966000172 potential frameshift: common BLAST hit: gi|172041642|ref|YP_001801356.1| transposase for insertion sequence 698966000173 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698966000174 Integrase core domain; Region: rve; pfam00665 698966000175 potential frameshift: common BLAST hit: gi|172041642|ref|YP_001801356.1| transposase for insertion sequence 698966000176 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698966000177 potential frameshift: common BLAST hit: gi|256832661|ref|YP_003161388.1| transposase IS204/IS1001/IS1096/IS1165 family protein 698966000178 Transposase; Region: DDE_Tnp_ISL3; pfam01610 698966000179 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 698966000180 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 698966000181 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698966000182 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 698966000183 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698966000184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966000185 Walker A/P-loop; other site 698966000186 ATP binding site [chemical binding]; other site 698966000187 Q-loop/lid; other site 698966000188 ABC transporter signature motif; other site 698966000189 Walker B; other site 698966000190 D-loop; other site 698966000191 H-loop/switch region; other site 698966000192 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698966000193 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698966000194 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966000195 Walker A/P-loop; other site 698966000196 ATP binding site [chemical binding]; other site 698966000197 Q-loop/lid; other site 698966000198 ABC transporter signature motif; other site 698966000199 Walker B; other site 698966000200 D-loop; other site 698966000201 H-loop/switch region; other site 698966000202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698966000203 S-adenosylmethionine binding site [chemical binding]; other site 698966000204 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698966000205 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 698966000206 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698966000207 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698966000208 catalytic residues [active] 698966000209 catalytic nucleophile [active] 698966000210 Presynaptic Site I dimer interface [polypeptide binding]; other site 698966000211 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698966000212 Synaptic Flat tetramer interface [polypeptide binding]; other site 698966000213 Synaptic Site I dimer interface [polypeptide binding]; other site 698966000214 DNA binding site [nucleotide binding] 698966000215 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698966000216 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 698966000217 catalytic residues [active] 698966000218 catalytic nucleophile [active] 698966000219 Recombinase; Region: Recombinase; pfam07508 698966000220 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 698966000221 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698966000222 HTH-like domain; Region: HTH_21; pfam13276 698966000223 Integrase core domain; Region: rve_2; pfam13333 698966000224 potential frameshift: common BLAST hit: gi|172041642|ref|YP_001801356.1| transposase for insertion sequence 698966000225 potential frameshift: common BLAST hit: gi|172041642|ref|YP_001801356.1| transposase for insertion sequence 698966000226 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698966000227 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698966000228 Integrase core domain; Region: rve; pfam00665 698966000229 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 698966000230 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 698966000231 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698966000232 Walker A/P-loop; other site 698966000233 ATP binding site [chemical binding]; other site 698966000234 Q-loop/lid; other site 698966000235 ABC transporter signature motif; other site 698966000236 Walker B; other site 698966000237 D-loop; other site 698966000238 H-loop/switch region; other site 698966000239 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698966000240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698966000241 active site 698966000242 phosphorylation site [posttranslational modification] 698966000243 intermolecular recognition site; other site 698966000244 dimerization interface [polypeptide binding]; other site 698966000245 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698966000246 DNA binding residues [nucleotide binding] 698966000247 dimerization interface [polypeptide binding]; other site 698966000248 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698966000249 Histidine kinase; Region: HisKA_3; pfam07730 698966000250 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698966000251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698966000252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698966000253 dimer interface [polypeptide binding]; other site 698966000254 conserved gate region; other site 698966000255 putative PBP binding loops; other site 698966000256 ABC-ATPase subunit interface; other site 698966000257 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 698966000258 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 698966000259 Walker A/P-loop; other site 698966000260 ATP binding site [chemical binding]; other site 698966000261 Q-loop/lid; other site 698966000262 ABC transporter signature motif; other site 698966000263 Walker B; other site 698966000264 D-loop; other site 698966000265 H-loop/switch region; other site 698966000266 Anti-sigma-K factor rskA; Region: RskA; pfam10099 698966000267 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 698966000268 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698966000269 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698966000270 DNA binding residues [nucleotide binding] 698966000271 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698966000272 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698966000273 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 698966000274 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698966000275 catalytic residues [active] 698966000276 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 698966000277 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698966000278 DNA binding residues [nucleotide binding] 698966000279 dimer interface [polypeptide binding]; other site 698966000280 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 698966000281 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 698966000282 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 698966000283 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 698966000284 putative metal binding site [ion binding]; other site 698966000285 biotin synthase; Validated; Region: PRK06256 698966000286 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698966000287 FeS/SAM binding site; other site 698966000288 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698966000289 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 698966000290 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 698966000291 putative ligand binding residues [chemical binding]; other site 698966000292 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698966000293 ABC-ATPase subunit interface; other site 698966000294 dimer interface [polypeptide binding]; other site 698966000295 putative PBP binding regions; other site 698966000296 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698966000297 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698966000298 Walker A/P-loop; other site 698966000299 ATP binding site [chemical binding]; other site 698966000300 Q-loop/lid; other site 698966000301 ABC transporter signature motif; other site 698966000302 Walker B; other site 698966000303 D-loop; other site 698966000304 H-loop/switch region; other site 698966000305 Uncharacterized conserved protein [Function unknown]; Region: COG5646 698966000306 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 698966000307 DNA photolyase; Region: DNA_photolyase; pfam00875 698966000308 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 698966000309 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 698966000310 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 698966000311 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 698966000312 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 698966000313 Lipase (class 2); Region: Lipase_2; pfam01674 698966000314 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 698966000315 FMN binding site [chemical binding]; other site 698966000316 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 698966000317 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 698966000318 trimer interface [polypeptide binding]; other site 698966000319 putative metal binding site [ion binding]; other site 698966000320 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698966000321 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 698966000322 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 698966000323 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 698966000324 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698966000325 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698966000326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 698966000327 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698966000328 MarR family; Region: MarR; pfam01047 698966000329 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 698966000330 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698966000331 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698966000332 hypothetical protein; Provisional; Region: PRK10621 698966000333 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698966000334 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 698966000335 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698966000336 ATP binding site [chemical binding]; other site 698966000337 putative Mg++ binding site [ion binding]; other site 698966000338 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698966000339 nucleotide binding region [chemical binding]; other site 698966000340 Helicase associated domain (HA2); Region: HA2; pfam04408 698966000341 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 698966000342 Maltose acetyltransferase; Region: Mac; pfam12464 698966000343 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 698966000344 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698966000345 putative trimer interface [polypeptide binding]; other site 698966000346 putative CoA binding site [chemical binding]; other site 698966000347 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698966000348 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 698966000349 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698966000350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698966000351 NAD(P) binding site [chemical binding]; other site 698966000352 active site 698966000353 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 698966000354 Helix-turn-helix domain; Region: HTH_28; pfam13518 698966000355 Integrase core domain; Region: rve_2; pfam13333 698966000356 potential frameshift: common BLAST hit: gi|336325819|ref|YP_004605785.1| transposase for insertion sequence element 698966000357 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698966000358 Integrase core domain; Region: rve; pfam00665 698966000359 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 698966000360 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698966000361 RNA binding surface [nucleotide binding]; other site 698966000362 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698966000363 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698966000364 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698966000365 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 698966000366 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 698966000367 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 698966000368 active site 698966000369 Zn binding site [ion binding]; other site 698966000370 Protease prsW family; Region: PrsW-protease; pfam13367 698966000371 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698966000372 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 698966000373 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 698966000374 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 698966000375 short chain dehydrogenase; Provisional; Region: PRK07904 698966000376 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698966000377 NAD(P) binding site [chemical binding]; other site 698966000378 active site 698966000379 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698966000380 FAD binding domain; Region: FAD_binding_4; pfam01565 698966000381 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 698966000382 Predicted membrane protein [Function unknown]; Region: COG2246 698966000383 GtrA-like protein; Region: GtrA; pfam04138 698966000384 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698966000385 putative active site [active] 698966000386 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698966000387 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698966000388 active site 698966000389 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698966000390 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698966000391 intersubunit interface [polypeptide binding]; other site 698966000392 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698966000393 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698966000394 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698966000395 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698966000396 ABC-ATPase subunit interface; other site 698966000397 dimer interface [polypeptide binding]; other site 698966000398 putative PBP binding regions; other site 698966000399 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698966000400 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698966000401 ABC-ATPase subunit interface; other site 698966000402 dimer interface [polypeptide binding]; other site 698966000403 putative PBP binding regions; other site 698966000404 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698966000405 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698966000406 intersubunit interface [polypeptide binding]; other site 698966000407 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 698966000408 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 698966000409 Walker A/P-loop; other site 698966000410 ATP binding site [chemical binding]; other site 698966000411 Q-loop/lid; other site 698966000412 ABC transporter signature motif; other site 698966000413 Walker B; other site 698966000414 D-loop; other site 698966000415 H-loop/switch region; other site 698966000416 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 698966000417 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698966000418 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698966000419 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698966000420 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698966000421 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 698966000422 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 698966000423 NAD(P) binding site [chemical binding]; other site 698966000424 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 698966000425 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698966000426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698966000427 homodimer interface [polypeptide binding]; other site 698966000428 catalytic residue [active] 698966000429 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 698966000430 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 698966000431 transmembrane helices; other site 698966000432 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698966000433 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 698966000434 NodB motif; other site 698966000435 active site 698966000436 catalytic site [active] 698966000437 metal binding site [ion binding]; metal-binding site 698966000438 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698966000439 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698966000440 DNA-binding site [nucleotide binding]; DNA binding site 698966000441 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698966000442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698966000443 homodimer interface [polypeptide binding]; other site 698966000444 catalytic residue [active] 698966000445 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 698966000446 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 698966000447 active site 698966000448 multimer interface [polypeptide binding]; other site 698966000449 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 698966000450 predicted active site [active] 698966000451 catalytic triad [active] 698966000452 potential frameshift: common BLAST hit: gi|68535288|ref|YP_249993.1| transposase IS3510a 698966000453 potential frameshift: common BLAST hit: gi|68535288|ref|YP_249993.1| transposase IS3510a 698966000454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698966000455 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698966000456 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698966000457 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698966000458 active site 698966000459 catalytic site [active] 698966000460 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698966000461 active site 698966000462 catalytic site [active] 698966000463 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698966000464 metal ion-dependent adhesion site (MIDAS); other site 698966000465 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 698966000466 prephenate dehydrogenase; Validated; Region: PRK08507 698966000467 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 698966000468 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 698966000469 nucleoside/Zn binding site; other site 698966000470 dimer interface [polypeptide binding]; other site 698966000471 catalytic motif [active] 698966000472 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 698966000473 DNA binding residues [nucleotide binding] 698966000474 PIN domain; Region: PIN_3; pfam13470 698966000475 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 698966000476 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 698966000477 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 698966000478 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 698966000479 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 698966000480 active site 698966000481 HIGH motif; other site 698966000482 nucleotide binding site [chemical binding]; other site 698966000483 active site 698966000484 KMSKS motif; other site 698966000485 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 698966000486 fructuronate transporter; Provisional; Region: PRK10034; cl15264 698966000487 Shikimate kinase; Region: SKI; pfam01202 698966000488 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 698966000489 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 698966000490 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 698966000491 putative NAD(P) binding site [chemical binding]; other site 698966000492 catalytic Zn binding site [ion binding]; other site 698966000493 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 698966000494 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 698966000495 NADP binding site [chemical binding]; other site 698966000496 homodimer interface [polypeptide binding]; other site 698966000497 active site 698966000498 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 698966000499 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698966000500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698966000501 homodimer interface [polypeptide binding]; other site 698966000502 catalytic residue [active] 698966000503 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 698966000504 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 698966000505 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698966000506 Walker A motif; other site 698966000507 ATP binding site [chemical binding]; other site 698966000508 Walker B motif; other site 698966000509 arginine finger; other site 698966000510 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 698966000511 hypothetical protein; Validated; Region: PRK00153 698966000512 recombination protein RecR; Reviewed; Region: recR; PRK00076 698966000513 RecR protein; Region: RecR; pfam02132 698966000514 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 698966000515 putative active site [active] 698966000516 putative metal-binding site [ion binding]; other site 698966000517 tetramer interface [polypeptide binding]; other site 698966000518 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698966000519 catalytic triad [active] 698966000520 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 698966000521 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698966000522 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 698966000523 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 698966000524 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698966000525 active site 698966000526 catalytic site [active] 698966000527 substrate binding site [chemical binding]; other site 698966000528 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 698966000529 FMN binding site [chemical binding]; other site 698966000530 NADPH bind site [chemical binding]; other site 698966000531 2-isopropylmalate synthase; Validated; Region: PRK03739 698966000532 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 698966000533 active site 698966000534 catalytic residues [active] 698966000535 metal binding site [ion binding]; metal-binding site 698966000536 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 698966000537 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698966000538 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698966000539 DNA binding residues [nucleotide binding] 698966000540 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698966000541 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698966000542 active site 698966000543 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 698966000544 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698966000545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966000546 putative substrate translocation pore; other site 698966000547 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 698966000548 intersubunit interface [polypeptide binding]; other site 698966000549 active site 698966000550 catalytic residue [active] 698966000551 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 698966000552 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 698966000553 active site 698966000554 substrate binding site [chemical binding]; other site 698966000555 metal binding site [ion binding]; metal-binding site 698966000556 aspartate kinase; Reviewed; Region: PRK06635 698966000557 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 698966000558 putative nucleotide binding site [chemical binding]; other site 698966000559 putative catalytic residues [active] 698966000560 putative Mg ion binding site [ion binding]; other site 698966000561 putative aspartate binding site [chemical binding]; other site 698966000562 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 698966000563 putative allosteric regulatory site; other site 698966000564 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 698966000565 putative allosteric regulatory residue; other site 698966000566 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 698966000567 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698966000568 RNA polymerase sigma factor; Provisional; Region: PRK12535 698966000569 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698966000570 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698966000571 DNA binding residues [nucleotide binding] 698966000572 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 698966000573 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 698966000574 heme binding pocket [chemical binding]; other site 698966000575 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698966000576 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 698966000577 Walker A/P-loop; other site 698966000578 ATP binding site [chemical binding]; other site 698966000579 Q-loop/lid; other site 698966000580 ABC transporter signature motif; other site 698966000581 Walker B; other site 698966000582 D-loop; other site 698966000583 H-loop/switch region; other site 698966000584 TOBE domain; Region: TOBE_2; pfam08402 698966000585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698966000586 dimer interface [polypeptide binding]; other site 698966000587 conserved gate region; other site 698966000588 ABC-ATPase subunit interface; other site 698966000589 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698966000590 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 698966000591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966000592 putative substrate translocation pore; other site 698966000593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966000594 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698966000595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698966000596 active site 698966000597 phosphorylation site [posttranslational modification] 698966000598 intermolecular recognition site; other site 698966000599 dimerization interface [polypeptide binding]; other site 698966000600 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698966000601 DNA binding site [nucleotide binding] 698966000602 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698966000603 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698966000604 dimer interface [polypeptide binding]; other site 698966000605 phosphorylation site [posttranslational modification] 698966000606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698966000607 ATP binding site [chemical binding]; other site 698966000608 Mg2+ binding site [ion binding]; other site 698966000609 G-X-G motif; other site 698966000610 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 698966000611 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 698966000612 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 698966000613 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 698966000614 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698966000615 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 698966000616 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 698966000617 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698966000618 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 698966000619 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698966000620 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698966000621 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698966000622 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698966000623 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698966000624 putative active site [active] 698966000625 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 698966000626 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698966000627 putative active site [active] 698966000628 putative metal binding site [ion binding]; other site 698966000629 Yqey-like protein; Region: YqeY; pfam09424 698966000630 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698966000631 Transglycosylase; Region: Transgly; pfam00912 698966000632 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698966000633 PASTA domain; Region: PASTA; pfam03793 698966000634 Transcription factor WhiB; Region: Whib; pfam02467 698966000635 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 698966000636 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 698966000637 homotrimer interaction site [polypeptide binding]; other site 698966000638 putative active site [active] 698966000639 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698966000640 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698966000641 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698966000642 ligand binding site [chemical binding]; other site 698966000643 flexible hinge region; other site 698966000644 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698966000645 putative switch regulator; other site 698966000646 non-specific DNA interactions [nucleotide binding]; other site 698966000647 DNA binding site [nucleotide binding] 698966000648 sequence specific DNA binding site [nucleotide binding]; other site 698966000649 putative cAMP binding site [chemical binding]; other site 698966000650 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 698966000651 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698966000652 minor groove reading motif; other site 698966000653 helix-hairpin-helix signature motif; other site 698966000654 substrate binding pocket [chemical binding]; other site 698966000655 active site 698966000656 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 698966000657 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698966000658 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698966000659 catalytic residues [active] 698966000660 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 698966000661 putative active site [active] 698966000662 putative CoA binding site [chemical binding]; other site 698966000663 nudix motif; other site 698966000664 metal binding site [ion binding]; metal-binding site 698966000665 Colicin V production protein; Region: Colicin_V; pfam02674 698966000666 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 698966000667 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698966000668 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698966000669 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698966000670 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 698966000671 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698966000672 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698966000673 motif II; other site 698966000674 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 698966000675 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 698966000676 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 698966000677 ATP binding site [chemical binding]; other site 698966000678 Walker A motif; other site 698966000679 hexamer interface [polypeptide binding]; other site 698966000680 Walker B motif; other site 698966000681 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 698966000682 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 698966000683 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 698966000684 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 698966000685 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698966000686 ATP binding site [chemical binding]; other site 698966000687 putative Mg++ binding site [ion binding]; other site 698966000688 nucleotide binding region [chemical binding]; other site 698966000689 helicase superfamily c-terminal domain; Region: HELICc; smart00490 698966000690 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 698966000691 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698966000692 DNA-binding site [nucleotide binding]; DNA binding site 698966000693 RNA-binding motif; other site 698966000694 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698966000695 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698966000696 Walker A/P-loop; other site 698966000697 ATP binding site [chemical binding]; other site 698966000698 Q-loop/lid; other site 698966000699 ABC transporter signature motif; other site 698966000700 Walker B; other site 698966000701 D-loop; other site 698966000702 H-loop/switch region; other site 698966000703 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698966000704 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698966000705 Walker A/P-loop; other site 698966000706 ATP binding site [chemical binding]; other site 698966000707 Q-loop/lid; other site 698966000708 ABC transporter signature motif; other site 698966000709 Walker B; other site 698966000710 D-loop; other site 698966000711 H-loop/switch region; other site 698966000712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966000713 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698966000714 putative substrate translocation pore; other site 698966000715 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698966000716 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 698966000717 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698966000718 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 698966000719 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698966000720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698966000721 dimer interface [polypeptide binding]; other site 698966000722 conserved gate region; other site 698966000723 putative PBP binding loops; other site 698966000724 ABC-ATPase subunit interface; other site 698966000725 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698966000726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698966000727 NAD(P) binding site [chemical binding]; other site 698966000728 active site 698966000729 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 698966000730 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 698966000731 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 698966000732 active site 698966000733 interdomain interaction site; other site 698966000734 putative metal-binding site [ion binding]; other site 698966000735 nucleotide binding site [chemical binding]; other site 698966000736 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 698966000737 domain I; other site 698966000738 DNA binding groove [nucleotide binding] 698966000739 phosphate binding site [ion binding]; other site 698966000740 domain II; other site 698966000741 domain III; other site 698966000742 nucleotide binding site [chemical binding]; other site 698966000743 catalytic site [active] 698966000744 domain IV; other site 698966000745 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 698966000746 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698966000747 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698966000748 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698966000749 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698966000750 active site 698966000751 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 698966000752 Predicted membrane protein [Function unknown]; Region: COG1297 698966000753 putative oligopeptide transporter, OPT family; Region: TIGR00733 698966000754 Laminin G domain; Region: Laminin_G_2; pfam02210 698966000755 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698966000756 catalytic site [active] 698966000757 Asp-box motif; other site 698966000758 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698966000759 dimerization interface [polypeptide binding]; other site 698966000760 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698966000761 cyclase homology domain; Region: CHD; cd07302 698966000762 nucleotidyl binding site; other site 698966000763 metal binding site [ion binding]; metal-binding site 698966000764 dimer interface [polypeptide binding]; other site 698966000765 DNA polymerase III subunit delta'; Validated; Region: PRK07940 698966000766 DNA polymerase III subunit delta'; Validated; Region: PRK08485 698966000767 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 698966000768 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698966000769 MULE transposase domain; Region: MULE; pfam10551 698966000770 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698966000771 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698966000772 Fic family protein [Function unknown]; Region: COG3177 698966000773 Fic/DOC family; Region: Fic; pfam02661 698966000774 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698966000775 Trypsin; Region: Trypsin; pfam00089 698966000776 active site 698966000777 HTH-like domain; Region: HTH_21; pfam13276 698966000778 Integrase core domain; Region: rve; pfam00665 698966000779 Transposase; Region: HTH_Tnp_1; cl17663 698966000780 acyl-CoA synthetase; Validated; Region: PRK07788 698966000781 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698966000782 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698966000783 acyl-activating enzyme (AAE) consensus motif; other site 698966000784 acyl-activating enzyme (AAE) consensus motif; other site 698966000785 AMP binding site [chemical binding]; other site 698966000786 active site 698966000787 CoA binding site [chemical binding]; other site 698966000788 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 698966000789 active site 698966000790 catalytic triad [active] 698966000791 oxyanion hole [active] 698966000792 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 698966000793 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 698966000794 substrate binding site; other site 698966000795 tetramer interface; other site 698966000796 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 698966000797 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 698966000798 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 698966000799 NADP binding site [chemical binding]; other site 698966000800 active site 698966000801 putative substrate binding site [chemical binding]; other site 698966000802 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 698966000803 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 698966000804 NAD binding site [chemical binding]; other site 698966000805 substrate binding site [chemical binding]; other site 698966000806 homodimer interface [polypeptide binding]; other site 698966000807 active site 698966000808 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 698966000809 Zn binding site [ion binding]; other site 698966000810 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 698966000811 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698966000812 Putative esterase; Region: Esterase; pfam00756 698966000813 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 698966000814 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 698966000815 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698966000816 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698966000817 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698966000818 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698966000819 non-specific DNA binding site [nucleotide binding]; other site 698966000820 salt bridge; other site 698966000821 sequence-specific DNA binding site [nucleotide binding]; other site 698966000822 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 698966000823 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698966000824 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 698966000825 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 698966000826 putative Iron-sulfur protein interface [polypeptide binding]; other site 698966000827 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 698966000828 proximal heme binding site [chemical binding]; other site 698966000829 distal heme binding site [chemical binding]; other site 698966000830 putative dimer interface [polypeptide binding]; other site 698966000831 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 698966000832 L-aspartate oxidase; Provisional; Region: PRK06175 698966000833 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 698966000834 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 698966000835 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 698966000836 Predicted membrane protein [Function unknown]; Region: COG2733 698966000837 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 698966000838 Class I aldolases; Region: Aldolase_Class_I; cd00945 698966000839 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698966000840 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 698966000841 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698966000842 FeS/SAM binding site; other site 698966000843 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 698966000844 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698966000845 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 698966000846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698966000847 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 698966000848 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 698966000849 FAD binding domain; Region: FAD_binding_4; pfam01565 698966000850 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 698966000851 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698966000852 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698966000853 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698966000854 acyl-activating enzyme (AAE) consensus motif; other site 698966000855 AMP binding site [chemical binding]; other site 698966000856 active site 698966000857 CoA binding site [chemical binding]; other site 698966000858 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698966000859 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698966000860 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698966000861 acyl-activating enzyme (AAE) consensus motif; other site 698966000862 AMP binding site [chemical binding]; other site 698966000863 active site 698966000864 CoA binding site [chemical binding]; other site 698966000865 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 698966000866 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 698966000867 putative ADP-binding pocket [chemical binding]; other site 698966000868 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698966000869 catalytic core [active] 698966000870 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698966000871 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698966000872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698966000873 dimer interface [polypeptide binding]; other site 698966000874 phosphorylation site [posttranslational modification] 698966000875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698966000876 ATP binding site [chemical binding]; other site 698966000877 Mg2+ binding site [ion binding]; other site 698966000878 G-X-G motif; other site 698966000879 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698966000880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698966000881 active site 698966000882 phosphorylation site [posttranslational modification] 698966000883 intermolecular recognition site; other site 698966000884 dimerization interface [polypeptide binding]; other site 698966000885 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698966000886 DNA binding site [nucleotide binding] 698966000887 exopolyphosphatase; Region: exo_poly_only; TIGR03706 698966000888 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698966000889 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 698966000890 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 698966000891 DNA binding domain, excisionase family; Region: excise; TIGR01764 698966000892 Thioredoxin; Region: Thioredoxin_4; cl17273 698966000893 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698966000894 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698966000895 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 698966000896 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698966000897 motif II; other site 698966000898 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 698966000899 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 698966000900 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 698966000901 tRNA; other site 698966000902 putative tRNA binding site [nucleotide binding]; other site 698966000903 putative NADP binding site [chemical binding]; other site 698966000904 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 698966000905 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 698966000906 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 698966000907 domain interfaces; other site 698966000908 active site 698966000909 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 698966000910 active site 698966000911 homodimer interface [polypeptide binding]; other site 698966000912 SAM binding site [chemical binding]; other site 698966000913 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 698966000914 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 698966000915 active site 698966000916 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 698966000917 dimer interface [polypeptide binding]; other site 698966000918 active site 698966000919 Schiff base residues; other site 698966000920 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 698966000921 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698966000922 Predicted membrane protein [Function unknown]; Region: COG2311 698966000923 Protein of unknown function (DUF418); Region: DUF418; pfam04235 698966000924 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 698966000925 substrate binding site [chemical binding]; other site 698966000926 active site 698966000927 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 698966000928 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 698966000929 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698966000930 inhibitor-cofactor binding pocket; inhibition site 698966000931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698966000932 catalytic residue [active] 698966000933 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698966000934 catalytic core [active] 698966000935 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698966000936 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698966000937 catalytic residues [active] 698966000938 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698966000939 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698966000940 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 698966000941 ResB-like family; Region: ResB; pfam05140 698966000942 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 698966000943 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698966000944 dimerization interface [polypeptide binding]; other site 698966000945 putative DNA binding site [nucleotide binding]; other site 698966000946 putative Zn2+ binding site [ion binding]; other site 698966000947 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 698966000948 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 698966000949 UbiA prenyltransferase family; Region: UbiA; pfam01040 698966000950 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698966000951 active site 698966000952 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698966000953 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 698966000954 acyl-activating enzyme (AAE) consensus motif; other site 698966000955 AMP binding site [chemical binding]; other site 698966000956 active site 698966000957 CoA binding site [chemical binding]; other site 698966000958 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 698966000959 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698966000960 substrate binding site [chemical binding]; other site 698966000961 oxyanion hole (OAH) forming residues; other site 698966000962 trimer interface [polypeptide binding]; other site 698966000963 O-succinylbenzoate synthase; Provisional; Region: PRK02901 698966000964 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 698966000965 active site 698966000966 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 698966000967 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 698966000968 dimer interface [polypeptide binding]; other site 698966000969 tetramer interface [polypeptide binding]; other site 698966000970 PYR/PP interface [polypeptide binding]; other site 698966000971 TPP binding site [chemical binding]; other site 698966000972 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 698966000973 TPP-binding site; other site 698966000974 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 698966000975 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698966000976 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 698966000977 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 698966000978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698966000979 S-adenosylmethionine binding site [chemical binding]; other site 698966000980 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 698966000981 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 698966000982 NAD binding site [chemical binding]; other site 698966000983 dimer interface [polypeptide binding]; other site 698966000984 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698966000985 substrate binding site [chemical binding]; other site 698966000986 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 698966000987 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698966000988 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698966000989 substrate binding pocket [chemical binding]; other site 698966000990 chain length determination region; other site 698966000991 substrate-Mg2+ binding site; other site 698966000992 catalytic residues [active] 698966000993 aspartate-rich region 1; other site 698966000994 active site lid residues [active] 698966000995 aspartate-rich region 2; other site 698966000996 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 698966000997 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 698966000998 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 698966000999 putative homodimer interface [polypeptide binding]; other site 698966001000 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 698966001001 heterodimer interface [polypeptide binding]; other site 698966001002 homodimer interface [polypeptide binding]; other site 698966001003 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 698966001004 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 698966001005 23S rRNA interface [nucleotide binding]; other site 698966001006 L7/L12 interface [polypeptide binding]; other site 698966001007 putative thiostrepton binding site; other site 698966001008 L25 interface [polypeptide binding]; other site 698966001009 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 698966001010 mRNA/rRNA interface [nucleotide binding]; other site 698966001011 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 698966001012 23S rRNA interface [nucleotide binding]; other site 698966001013 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 698966001014 50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157 698966001015 L11 interface [polypeptide binding]; other site 698966001016 putative EF-Tu interaction site [polypeptide binding]; other site 698966001017 putative EF-G interaction site [polypeptide binding]; other site 698966001018 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 698966001019 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698966001020 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698966001021 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698966001022 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698966001023 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698966001024 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 698966001025 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698966001026 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698966001027 ABC-ATPase subunit interface; other site 698966001028 dimer interface [polypeptide binding]; other site 698966001029 putative PBP binding regions; other site 698966001030 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698966001031 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698966001032 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698966001033 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698966001034 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 698966001035 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 698966001036 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 698966001037 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 698966001038 RPB1 interaction site [polypeptide binding]; other site 698966001039 RPB10 interaction site [polypeptide binding]; other site 698966001040 RPB11 interaction site [polypeptide binding]; other site 698966001041 RPB3 interaction site [polypeptide binding]; other site 698966001042 RPB12 interaction site [polypeptide binding]; other site 698966001043 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 698966001044 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 698966001045 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 698966001046 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 698966001047 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 698966001048 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698966001049 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 698966001050 G-loop; other site 698966001051 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698966001052 DNA binding site [nucleotide binding] 698966001053 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 698966001054 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698966001055 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698966001056 Walker A/P-loop; other site 698966001057 ATP binding site [chemical binding]; other site 698966001058 Q-loop/lid; other site 698966001059 ABC transporter signature motif; other site 698966001060 Walker B; other site 698966001061 D-loop; other site 698966001062 H-loop/switch region; other site 698966001063 potential frameshift: common BLAST hit: gi|19554259|ref|NP_602261.1| helicase 698966001064 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 698966001065 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698966001066 ATP binding site [chemical binding]; other site 698966001067 putative Mg++ binding site [ion binding]; other site 698966001068 Predicted helicase [General function prediction only]; Region: COG4889 698966001069 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698966001070 nucleotide binding region [chemical binding]; other site 698966001071 ATP-binding site [chemical binding]; other site 698966001072 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698966001073 Histidine kinase; Region: HisKA_3; pfam07730 698966001074 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698966001075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698966001076 active site 698966001077 phosphorylation site [posttranslational modification] 698966001078 intermolecular recognition site; other site 698966001079 dimerization interface [polypeptide binding]; other site 698966001080 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698966001081 DNA binding residues [nucleotide binding] 698966001082 dimerization interface [polypeptide binding]; other site 698966001083 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698966001084 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698966001085 Walker A/P-loop; other site 698966001086 ATP binding site [chemical binding]; other site 698966001087 Q-loop/lid; other site 698966001088 ABC transporter signature motif; other site 698966001089 Walker B; other site 698966001090 D-loop; other site 698966001091 H-loop/switch region; other site 698966001092 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 698966001093 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698966001094 TIGR03943 family protein; Region: TIGR03943 698966001095 Predicted permeases [General function prediction only]; Region: COG0701 698966001096 Radical SAM superfamily; Region: Radical_SAM; pfam04055 698966001097 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698966001098 FeS/SAM binding site; other site 698966001099 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 698966001100 Class III ribonucleotide reductase; Region: RNR_III; cd01675 698966001101 effector binding site; other site 698966001102 active site 698966001103 Zn binding site [ion binding]; other site 698966001104 glycine loop; other site 698966001105 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 698966001106 S17 interaction site [polypeptide binding]; other site 698966001107 S8 interaction site; other site 698966001108 16S rRNA interaction site [nucleotide binding]; other site 698966001109 streptomycin interaction site [chemical binding]; other site 698966001110 23S rRNA interaction site [nucleotide binding]; other site 698966001111 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 698966001112 30S ribosomal protein S7; Validated; Region: PRK05302 698966001113 elongation factor G; Reviewed; Region: PRK00007 698966001114 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 698966001115 G1 box; other site 698966001116 putative GEF interaction site [polypeptide binding]; other site 698966001117 GTP/Mg2+ binding site [chemical binding]; other site 698966001118 Switch I region; other site 698966001119 G2 box; other site 698966001120 G3 box; other site 698966001121 Switch II region; other site 698966001122 G4 box; other site 698966001123 G5 box; other site 698966001124 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 698966001125 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 698966001126 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 698966001127 elongation factor Tu; Reviewed; Region: PRK00049 698966001128 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 698966001129 G1 box; other site 698966001130 GEF interaction site [polypeptide binding]; other site 698966001131 GTP/Mg2+ binding site [chemical binding]; other site 698966001132 Switch I region; other site 698966001133 G2 box; other site 698966001134 G3 box; other site 698966001135 Switch II region; other site 698966001136 G4 box; other site 698966001137 G5 box; other site 698966001138 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 698966001139 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 698966001140 Antibiotic Binding Site [chemical binding]; other site 698966001141 Predicted membrane protein [Function unknown]; Region: COG2323 698966001142 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 698966001143 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 698966001144 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 698966001145 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 698966001146 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 698966001147 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 698966001148 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 698966001149 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 698966001150 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 698966001151 putative translocon binding site; other site 698966001152 protein-rRNA interface [nucleotide binding]; other site 698966001153 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 698966001154 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 698966001155 G-X-X-G motif; other site 698966001156 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 698966001157 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 698966001158 23S rRNA interface [nucleotide binding]; other site 698966001159 5S rRNA interface [nucleotide binding]; other site 698966001160 putative antibiotic binding site [chemical binding]; other site 698966001161 L25 interface [polypeptide binding]; other site 698966001162 L27 interface [polypeptide binding]; other site 698966001163 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 698966001164 putative translocon interaction site; other site 698966001165 23S rRNA interface [nucleotide binding]; other site 698966001166 signal recognition particle (SRP54) interaction site; other site 698966001167 L23 interface [polypeptide binding]; other site 698966001168 trigger factor interaction site; other site 698966001169 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 698966001170 HlyD family secretion protein; Region: HlyD_3; pfam13437 698966001171 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698966001172 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698966001173 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698966001174 Walker A/P-loop; other site 698966001175 ATP binding site [chemical binding]; other site 698966001176 Q-loop/lid; other site 698966001177 ABC transporter signature motif; other site 698966001178 Walker B; other site 698966001179 D-loop; other site 698966001180 H-loop/switch region; other site 698966001181 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698966001182 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698966001183 FtsX-like permease family; Region: FtsX; pfam02687 698966001184 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 698966001185 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 698966001186 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 698966001187 RNA binding site [nucleotide binding]; other site 698966001188 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 698966001189 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 698966001190 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 698966001191 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 698966001192 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 698966001193 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698966001194 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698966001195 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698966001196 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698966001197 active site 698966001198 homotetramer interface [polypeptide binding]; other site 698966001199 homodimer interface [polypeptide binding]; other site 698966001200 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 698966001201 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698966001202 ATP binding site [chemical binding]; other site 698966001203 substrate interface [chemical binding]; other site 698966001204 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698966001205 active site residue [active] 698966001206 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698966001207 MPT binding site; other site 698966001208 trimer interface [polypeptide binding]; other site 698966001209 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 698966001210 MoaE homodimer interface [polypeptide binding]; other site 698966001211 MoaD interaction [polypeptide binding]; other site 698966001212 active site residues [active] 698966001213 Predicted transcriptional regulator [Transcription]; Region: COG2345 698966001214 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 698966001215 DNA binding residues [nucleotide binding] 698966001216 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698966001217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698966001218 dimer interface [polypeptide binding]; other site 698966001219 conserved gate region; other site 698966001220 putative PBP binding loops; other site 698966001221 ABC-ATPase subunit interface; other site 698966001222 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966001223 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 698966001224 Walker A/P-loop; other site 698966001225 ATP binding site [chemical binding]; other site 698966001226 Q-loop/lid; other site 698966001227 ABC transporter signature motif; other site 698966001228 Walker B; other site 698966001229 D-loop; other site 698966001230 H-loop/switch region; other site 698966001231 TOBE domain; Region: TOBE; cl01440 698966001232 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 698966001233 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698966001234 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 698966001235 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 698966001236 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 698966001237 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 698966001238 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 698966001239 [4Fe-4S] binding site [ion binding]; other site 698966001240 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698966001241 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698966001242 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698966001243 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 698966001244 molybdopterin cofactor binding site; other site 698966001245 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 698966001246 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 698966001247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966001248 putative substrate translocation pore; other site 698966001249 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698966001250 MPT binding site; other site 698966001251 trimer interface [polypeptide binding]; other site 698966001252 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 698966001253 GTP binding site; other site 698966001254 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 698966001255 trimer interface [polypeptide binding]; other site 698966001256 dimer interface [polypeptide binding]; other site 698966001257 putative active site [active] 698966001258 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698966001259 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698966001260 dimer interface [polypeptide binding]; other site 698966001261 putative functional site; other site 698966001262 putative MPT binding site; other site 698966001263 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 698966001264 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698966001265 FeS/SAM binding site; other site 698966001266 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 698966001267 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698966001268 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698966001269 inhibitor site; inhibition site 698966001270 active site 698966001271 dimer interface [polypeptide binding]; other site 698966001272 catalytic residue [active] 698966001273 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698966001274 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698966001275 Walker A/P-loop; other site 698966001276 ATP binding site [chemical binding]; other site 698966001277 Q-loop/lid; other site 698966001278 ABC transporter signature motif; other site 698966001279 Walker B; other site 698966001280 D-loop; other site 698966001281 H-loop/switch region; other site 698966001282 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698966001283 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698966001284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698966001285 dimer interface [polypeptide binding]; other site 698966001286 conserved gate region; other site 698966001287 putative PBP binding loops; other site 698966001288 ABC-ATPase subunit interface; other site 698966001289 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698966001290 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698966001291 Walker A/P-loop; other site 698966001292 ATP binding site [chemical binding]; other site 698966001293 Q-loop/lid; other site 698966001294 ABC transporter signature motif; other site 698966001295 Walker B; other site 698966001296 D-loop; other site 698966001297 H-loop/switch region; other site 698966001298 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698966001299 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698966001300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698966001301 dimer interface [polypeptide binding]; other site 698966001302 conserved gate region; other site 698966001303 putative PBP binding loops; other site 698966001304 ABC-ATPase subunit interface; other site 698966001305 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 698966001306 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698966001307 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698966001308 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698966001309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698966001310 DNA-binding site [nucleotide binding]; DNA binding site 698966001311 FCD domain; Region: FCD; pfam07729 698966001312 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698966001313 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698966001314 nucleotide binding site [chemical binding]; other site 698966001315 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 698966001316 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 698966001317 putative active site cavity [active] 698966001318 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 698966001319 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 698966001320 active site 698966001321 dimer interface [polypeptide binding]; other site 698966001322 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698966001323 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 698966001324 active site 698966001325 trimer interface [polypeptide binding]; other site 698966001326 allosteric site; other site 698966001327 active site lid [active] 698966001328 hexamer (dimer of trimers) interface [polypeptide binding]; other site 698966001329 Htaa; Region: HtaA; pfam04213 698966001330 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 698966001331 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 698966001332 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698966001333 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698966001334 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 698966001335 5S rRNA interface [nucleotide binding]; other site 698966001336 L27 interface [polypeptide binding]; other site 698966001337 23S rRNA interface [nucleotide binding]; other site 698966001338 L5 interface [polypeptide binding]; other site 698966001339 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 698966001340 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 698966001341 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 698966001342 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 698966001343 23S rRNA binding site [nucleotide binding]; other site 698966001344 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 698966001345 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 698966001346 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 698966001347 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 698966001348 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698966001349 active site 698966001350 catalytic site [active] 698966001351 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698966001352 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698966001353 active site 698966001354 catalytic site [active] 698966001355 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 698966001356 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698966001357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698966001358 dimer interface [polypeptide binding]; other site 698966001359 conserved gate region; other site 698966001360 putative PBP binding loops; other site 698966001361 ABC-ATPase subunit interface; other site 698966001362 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698966001363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698966001364 dimer interface [polypeptide binding]; other site 698966001365 conserved gate region; other site 698966001366 putative PBP binding loops; other site 698966001367 ABC-ATPase subunit interface; other site 698966001368 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 698966001369 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698966001370 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698966001371 Walker A/P-loop; other site 698966001372 ATP binding site [chemical binding]; other site 698966001373 Q-loop/lid; other site 698966001374 ABC transporter signature motif; other site 698966001375 Walker B; other site 698966001376 D-loop; other site 698966001377 H-loop/switch region; other site 698966001378 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 698966001379 SecY translocase; Region: SecY; pfam00344 698966001380 adenylate kinase; Reviewed; Region: adk; PRK00279 698966001381 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 698966001382 AMP-binding site [chemical binding]; other site 698966001383 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 698966001384 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698966001385 active site 698966001386 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698966001387 catalytic site [active] 698966001388 BNR repeat-like domain; Region: BNR_2; pfam13088 698966001389 Asp-box motif; other site 698966001390 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698966001391 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 698966001392 rRNA binding site [nucleotide binding]; other site 698966001393 predicted 30S ribosome binding site; other site 698966001394 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 698966001395 30S ribosomal protein S13; Region: bact_S13; TIGR03631 698966001396 30S ribosomal protein S11; Validated; Region: PRK05309 698966001397 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 698966001398 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 698966001399 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698966001400 RNA binding surface [nucleotide binding]; other site 698966001401 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 698966001402 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 698966001403 alphaNTD - beta interaction site [polypeptide binding]; other site 698966001404 alphaNTD homodimer interface [polypeptide binding]; other site 698966001405 alphaNTD - beta' interaction site [polypeptide binding]; other site 698966001406 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 698966001407 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 698966001408 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 698966001409 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 698966001410 dimerization interface 3.5A [polypeptide binding]; other site 698966001411 active site 698966001412 Protein of unknown function (DUF690); Region: DUF690; cl04939 698966001413 TIGR02611 family protein; Region: TIGR02611 698966001414 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 698966001415 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 698966001416 active site 698966001417 catalytic residues [active] 698966001418 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 698966001419 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 698966001420 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698966001421 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 698966001422 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698966001423 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698966001424 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 698966001425 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 698966001426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 698966001427 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 698966001428 23S rRNA interface [nucleotide binding]; other site 698966001429 L3 interface [polypeptide binding]; other site 698966001430 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 698966001431 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 698966001432 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 698966001433 active site 698966001434 substrate binding site [chemical binding]; other site 698966001435 metal binding site [ion binding]; metal-binding site 698966001436 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 698966001437 alanine racemase; Reviewed; Region: alr; PRK00053 698966001438 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 698966001439 active site 698966001440 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698966001441 dimer interface [polypeptide binding]; other site 698966001442 substrate binding site [chemical binding]; other site 698966001443 catalytic residues [active] 698966001444 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 698966001445 Predicted permease [General function prediction only]; Region: COG2985 698966001446 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698966001447 TrkA-C domain; Region: TrkA_C; pfam02080 698966001448 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698966001449 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698966001450 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 698966001451 Glycoprotease family; Region: Peptidase_M22; pfam00814 698966001452 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698966001453 Coenzyme A binding pocket [chemical binding]; other site 698966001454 UGMP family protein; Validated; Region: PRK09604 698966001455 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 698966001456 oligomerisation interface [polypeptide binding]; other site 698966001457 mobile loop; other site 698966001458 roof hairpin; other site 698966001459 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698966001460 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698966001461 ring oligomerisation interface [polypeptide binding]; other site 698966001462 ATP/Mg binding site [chemical binding]; other site 698966001463 stacking interactions; other site 698966001464 hinge regions; other site 698966001465 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 698966001466 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698966001467 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698966001468 DNA binding residues [nucleotide binding] 698966001469 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 698966001470 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698966001471 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 698966001472 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 698966001473 active site 698966001474 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 698966001475 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698966001476 phosphate binding site [ion binding]; other site 698966001477 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698966001478 siderophore binding site; other site 698966001479 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698966001480 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698966001481 dimer interface [polypeptide binding]; other site 698966001482 putative PBP binding regions; other site 698966001483 ABC-ATPase subunit interface; other site 698966001484 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698966001485 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698966001486 ABC-ATPase subunit interface; other site 698966001487 dimer interface [polypeptide binding]; other site 698966001488 putative PBP binding regions; other site 698966001489 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698966001490 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698966001491 Walker A/P-loop; other site 698966001492 ATP binding site [chemical binding]; other site 698966001493 Q-loop/lid; other site 698966001494 ABC transporter signature motif; other site 698966001495 Walker B; other site 698966001496 D-loop; other site 698966001497 H-loop/switch region; other site 698966001498 IucA / IucC family; Region: IucA_IucC; pfam04183 698966001499 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698966001500 IucA / IucC family; Region: IucA_IucC; pfam04183 698966001501 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698966001502 H+ Antiporter protein; Region: 2A0121; TIGR00900 698966001503 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 698966001504 EamA-like transporter family; Region: EamA; pfam00892 698966001505 GMP synthase; Reviewed; Region: guaA; PRK00074 698966001506 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 698966001507 AMP/PPi binding site [chemical binding]; other site 698966001508 candidate oxyanion hole; other site 698966001509 catalytic triad [active] 698966001510 potential glutamine specificity residues [chemical binding]; other site 698966001511 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 698966001512 ATP Binding subdomain [chemical binding]; other site 698966001513 Ligand Binding sites [chemical binding]; other site 698966001514 Dimerization subdomain; other site 698966001515 PspC domain; Region: PspC; pfam04024 698966001516 PspC domain; Region: PspC; pfam04024 698966001517 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698966001518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698966001519 ATP binding site [chemical binding]; other site 698966001520 Mg2+ binding site [ion binding]; other site 698966001521 G-X-G motif; other site 698966001522 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698966001523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698966001524 active site 698966001525 phosphorylation site [posttranslational modification] 698966001526 intermolecular recognition site; other site 698966001527 dimerization interface [polypeptide binding]; other site 698966001528 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698966001529 DNA binding residues [nucleotide binding] 698966001530 dimerization interface [polypeptide binding]; other site 698966001531 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698966001532 intersubunit interface [polypeptide binding]; other site 698966001533 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698966001534 DNA Polymerase Y-family; Region: PolY_like; cd03468 698966001535 active site 698966001536 DNA binding site [nucleotide binding] 698966001537 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 698966001538 putative dimer interface [polypeptide binding]; other site 698966001539 putative [2Fe-2S] cluster binding site [ion binding]; other site 698966001540 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698966001541 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698966001542 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698966001543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698966001544 dimer interface [polypeptide binding]; other site 698966001545 conserved gate region; other site 698966001546 ABC-ATPase subunit interface; other site 698966001547 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 698966001548 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 698966001549 Walker A/P-loop; other site 698966001550 ATP binding site [chemical binding]; other site 698966001551 Q-loop/lid; other site 698966001552 ABC transporter signature motif; other site 698966001553 Walker B; other site 698966001554 D-loop; other site 698966001555 H-loop/switch region; other site 698966001556 NIL domain; Region: NIL; cl09633 698966001557 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698966001558 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 698966001559 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698966001560 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 698966001561 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 698966001562 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 698966001563 active site 698966001564 PHP Thumb interface [polypeptide binding]; other site 698966001565 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698966001566 generic binding surface II; other site 698966001567 generic binding surface I; other site 698966001568 Uncharacterized conserved protein [Function unknown]; Region: COG3402 698966001569 Predicted membrane protein [Function unknown]; Region: COG3428 698966001570 Bacterial PH domain; Region: DUF304; pfam03703 698966001571 Bacterial PH domain; Region: DUF304; pfam03703 698966001572 Bacterial PH domain; Region: DUF304; pfam03703 698966001573 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698966001574 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698966001575 intersubunit interface [polypeptide binding]; other site 698966001576 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698966001577 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698966001578 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698966001579 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698966001580 dimer interface [polypeptide binding]; other site 698966001581 putative PBP binding regions; other site 698966001582 ABC-ATPase subunit interface; other site 698966001583 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698966001584 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698966001585 ABC-ATPase subunit interface; other site 698966001586 dimer interface [polypeptide binding]; other site 698966001587 putative PBP binding regions; other site 698966001588 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698966001589 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698966001590 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698966001591 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 698966001592 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 698966001593 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 698966001594 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 698966001595 homodimer interface [polypeptide binding]; other site 698966001596 NADP binding site [chemical binding]; other site 698966001597 substrate binding site [chemical binding]; other site 698966001598 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 698966001599 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698966001600 active site 698966001601 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 698966001602 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 698966001603 Htaa; Region: HtaA; pfam04213 698966001604 Htaa; Region: HtaA; pfam04213 698966001605 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698966001606 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698966001607 intersubunit interface [polypeptide binding]; other site 698966001608 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698966001609 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698966001610 ABC-ATPase subunit interface; other site 698966001611 dimer interface [polypeptide binding]; other site 698966001612 putative PBP binding regions; other site 698966001613 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 698966001614 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698966001615 Walker A/P-loop; other site 698966001616 ATP binding site [chemical binding]; other site 698966001617 Q-loop/lid; other site 698966001618 ABC transporter signature motif; other site 698966001619 Walker B; other site 698966001620 D-loop; other site 698966001621 H-loop/switch region; other site 698966001622 Htaa; Region: HtaA; pfam04213 698966001623 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 698966001624 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698966001625 homodimer interface [polypeptide binding]; other site 698966001626 substrate-cofactor binding pocket; other site 698966001627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698966001628 catalytic residue [active] 698966001629 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 698966001630 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 698966001631 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698966001632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966001633 putative substrate translocation pore; other site 698966001634 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698966001635 putative catalytic site [active] 698966001636 putative metal binding site [ion binding]; other site 698966001637 putative phosphate binding site [ion binding]; other site 698966001638 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 698966001639 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 698966001640 active site 698966001641 HIGH motif; other site 698966001642 dimer interface [polypeptide binding]; other site 698966001643 KMSKS motif; other site 698966001644 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 698966001645 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698966001646 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698966001647 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698966001648 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698966001649 NlpC/P60 family; Region: NLPC_P60; pfam00877 698966001650 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698966001651 active site 698966001652 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698966001653 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698966001654 non-specific DNA binding site [nucleotide binding]; other site 698966001655 salt bridge; other site 698966001656 sequence-specific DNA binding site [nucleotide binding]; other site 698966001657 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698966001658 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 698966001659 metal binding site [ion binding]; metal-binding site 698966001660 putative dimer interface [polypeptide binding]; other site 698966001661 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 698966001662 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698966001663 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698966001664 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698966001665 pyruvate carboxylase; Reviewed; Region: PRK12999 698966001666 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698966001667 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698966001668 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698966001669 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698966001670 active site 698966001671 catalytic residues [active] 698966001672 metal binding site [ion binding]; metal-binding site 698966001673 homodimer binding site [polypeptide binding]; other site 698966001674 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698966001675 carboxyltransferase (CT) interaction site; other site 698966001676 biotinylation site [posttranslational modification]; other site 698966001677 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 698966001678 ADP-ribose binding site [chemical binding]; other site 698966001679 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 698966001680 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698966001681 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 698966001682 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698966001683 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698966001684 carboxyltransferase (CT) interaction site; other site 698966001685 biotinylation site [posttranslational modification]; other site 698966001686 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698966001687 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698966001688 active site residue [active] 698966001689 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 698966001690 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698966001691 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 698966001692 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 698966001693 active site 698966001694 dimer interface [polypeptide binding]; other site 698966001695 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 698966001696 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698966001697 substrate binding site [chemical binding]; other site 698966001698 dimer interface [polypeptide binding]; other site 698966001699 ATP binding site [chemical binding]; other site 698966001700 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698966001701 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698966001702 DNA binding site [nucleotide binding] 698966001703 domain linker motif; other site 698966001704 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 698966001705 dimerization interface [polypeptide binding]; other site 698966001706 putative ligand binding site [chemical binding]; other site 698966001707 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 698966001708 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698966001709 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698966001710 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698966001711 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698966001712 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698966001713 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698966001714 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 698966001715 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 698966001716 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 698966001717 ATP-grasp domain; Region: ATP-grasp; pfam02222 698966001718 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 698966001719 Uncharacterized conserved protein [Function unknown]; Region: COG1434 698966001720 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698966001721 putative active site [active] 698966001722 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 698966001723 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 698966001724 HupF/HypC family; Region: HupF_HypC; pfam01455 698966001725 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 698966001726 dimerization interface [polypeptide binding]; other site 698966001727 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 698966001728 ATP binding site [chemical binding]; other site 698966001729 Acylphosphatase; Region: Acylphosphatase; pfam00708 698966001730 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 698966001731 HypF finger; Region: zf-HYPF; pfam07503 698966001732 HypF finger; Region: zf-HYPF; pfam07503 698966001733 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 698966001734 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 698966001735 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698966001736 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 698966001737 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 698966001738 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 698966001739 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 698966001740 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 698966001741 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 698966001742 putative substrate-binding site; other site 698966001743 nickel binding site [ion binding]; other site 698966001744 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 698966001745 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 698966001746 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 698966001747 HupF/HypC family; Region: HupF_HypC; cl00394 698966001748 TIGR03089 family protein; Region: TIGR03089 698966001749 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698966001750 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698966001751 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698966001752 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698966001753 active site 698966001754 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698966001755 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 698966001756 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 698966001757 active site 698966001758 Substrate binding site; other site 698966001759 Mg++ binding site; other site 698966001760 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698966001761 putative trimer interface [polypeptide binding]; other site 698966001762 putative CoA binding site [chemical binding]; other site 698966001763 Transcription factor WhiB; Region: Whib; pfam02467 698966001764 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 698966001765 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 698966001766 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 698966001767 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 698966001768 active site 698966001769 substrate binding site [chemical binding]; other site 698966001770 metal binding site [ion binding]; metal-binding site 698966001771 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 698966001772 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698966001773 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698966001774 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 698966001775 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 698966001776 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 698966001777 homotetramer interface [polypeptide binding]; other site 698966001778 ligand binding site [chemical binding]; other site 698966001779 catalytic site [active] 698966001780 NAD binding site [chemical binding]; other site 698966001781 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 698966001782 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 698966001783 TMP-binding site; other site 698966001784 ATP-binding site [chemical binding]; other site 698966001785 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698966001786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698966001787 active site 698966001788 phosphorylation site [posttranslational modification] 698966001789 intermolecular recognition site; other site 698966001790 dimerization interface [polypeptide binding]; other site 698966001791 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698966001792 DNA binding site [nucleotide binding] 698966001793 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698966001794 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698966001795 dimerization interface [polypeptide binding]; other site 698966001796 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698966001797 dimer interface [polypeptide binding]; other site 698966001798 phosphorylation site [posttranslational modification] 698966001799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698966001800 ATP binding site [chemical binding]; other site 698966001801 Mg2+ binding site [ion binding]; other site 698966001802 G-X-G motif; other site 698966001803 lipoprotein LpqB; Provisional; Region: PRK13616 698966001804 Sporulation and spore germination; Region: Germane; pfam10646 698966001805 comF family protein; Region: comF; TIGR00201 698966001806 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698966001807 active site 698966001808 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 698966001809 30S subunit binding site; other site 698966001810 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 698966001811 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698966001812 ATP binding site [chemical binding]; other site 698966001813 putative Mg++ binding site [ion binding]; other site 698966001814 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 698966001815 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698966001816 nucleotide binding region [chemical binding]; other site 698966001817 ATP-binding site [chemical binding]; other site 698966001818 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 698966001819 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 698966001820 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698966001821 FAD binding pocket [chemical binding]; other site 698966001822 FAD binding motif [chemical binding]; other site 698966001823 phosphate binding motif [ion binding]; other site 698966001824 beta-alpha-beta structure motif; other site 698966001825 NAD binding pocket [chemical binding]; other site 698966001826 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698966001827 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 698966001828 catalytic loop [active] 698966001829 iron binding site [ion binding]; other site 698966001830 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 698966001831 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 698966001832 putative di-iron ligands [ion binding]; other site 698966001833 Predicted GTPases [General function prediction only]; Region: COG1162 698966001834 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 698966001835 GTPase/Zn-binding domain interface [polypeptide binding]; other site 698966001836 GTP/Mg2+ binding site [chemical binding]; other site 698966001837 G4 box; other site 698966001838 G5 box; other site 698966001839 G1 box; other site 698966001840 Switch I region; other site 698966001841 G2 box; other site 698966001842 G3 box; other site 698966001843 Switch II region; other site 698966001844 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 698966001845 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 698966001846 hinge; other site 698966001847 active site 698966001848 Uncharacterized conserved protein [Function unknown]; Region: COG2135 698966001849 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 698966001850 putative deacylase active site [active] 698966001851 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 698966001852 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698966001853 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698966001854 DNA binding residues [nucleotide binding] 698966001855 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 698966001856 Transcription factor WhiB; Region: Whib; pfam02467 698966001857 PQQ-like domain; Region: PQQ_2; pfam13360 698966001858 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698966001859 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698966001860 ATP binding site [chemical binding]; other site 698966001861 putative Mg++ binding site [ion binding]; other site 698966001862 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698966001863 nucleotide binding region [chemical binding]; other site 698966001864 ATP-binding site [chemical binding]; other site 698966001865 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 698966001866 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 698966001867 TIGR02569 family protein; Region: TIGR02569_actnb 698966001868 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698966001869 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698966001870 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698966001871 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698966001872 Part of AAA domain; Region: AAA_19; pfam13245 698966001873 Family description; Region: UvrD_C_2; pfam13538 698966001874 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698966001875 Ion channel; Region: Ion_trans_2; pfam07885 698966001876 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 698966001877 TrkA-N domain; Region: TrkA_N; pfam02254 698966001878 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 698966001879 putative NADH binding site [chemical binding]; other site 698966001880 putative active site [active] 698966001881 nudix motif; other site 698966001882 putative metal binding site [ion binding]; other site 698966001883 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 698966001884 Part of AAA domain; Region: AAA_19; pfam13245 698966001885 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698966001886 Family description; Region: UvrD_C_2; pfam13538 698966001887 HRDC domain; Region: HRDC; pfam00570 698966001888 Protein of unknown function DUF45; Region: DUF45; pfam01863 698966001889 putative hydrolase; Region: TIGR03624 698966001890 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 698966001891 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698966001892 hypothetical protein; Validated; Region: PRK00068 698966001893 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 698966001894 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698966001895 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 698966001896 active site 698966001897 Protein of unknown function (DUF418); Region: DUF418; cl12135 698966001898 oxaloacetate decarboxylase; Provisional; Region: PRK12330 698966001899 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698966001900 active site 698966001901 catalytic residues [active] 698966001902 metal binding site [ion binding]; metal-binding site 698966001903 homodimer binding site [polypeptide binding]; other site 698966001904 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 698966001905 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698966001906 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698966001907 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698966001908 carboxyltransferase (CT) interaction site; other site 698966001909 biotinylation site [posttranslational modification]; other site 698966001910 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698966001911 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 698966001912 active site 698966001913 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698966001914 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698966001915 active site 698966001916 peptide chain release factor 2; Validated; Region: prfB; PRK00578 698966001917 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698966001918 RF-1 domain; Region: RF-1; pfam00472 698966001919 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 698966001920 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 698966001921 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698966001922 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966001923 Walker A/P-loop; other site 698966001924 ATP binding site [chemical binding]; other site 698966001925 Q-loop/lid; other site 698966001926 ABC transporter signature motif; other site 698966001927 Walker B; other site 698966001928 D-loop; other site 698966001929 H-loop/switch region; other site 698966001930 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 698966001931 FtsX-like permease family; Region: FtsX; pfam02687 698966001932 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 698966001933 SmpB-tmRNA interface; other site 698966001934 Cupin domain; Region: Cupin_2; cl17218 698966001935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698966001936 S-adenosylmethionine binding site [chemical binding]; other site 698966001937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698966001938 Helix-turn-helix domain; Region: HTH_28; pfam13518 698966001939 putative transposase OrfB; Reviewed; Region: PHA02517 698966001940 HTH-like domain; Region: HTH_21; pfam13276 698966001941 Integrase core domain; Region: rve; pfam00665 698966001942 Integrase core domain; Region: rve_2; pfam13333 698966001943 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698966001944 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698966001945 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698966001946 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698966001947 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698966001948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698966001949 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 698966001950 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698966001951 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698966001952 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698966001953 nucleotide binding region [chemical binding]; other site 698966001954 ATP-binding site [chemical binding]; other site 698966001955 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698966001956 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698966001957 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 698966001958 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698966001959 DNA-binding site [nucleotide binding]; DNA binding site 698966001960 RNA-binding motif; other site 698966001961 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 698966001962 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 698966001963 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 698966001964 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 698966001965 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698966001966 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698966001967 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 698966001968 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698966001969 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698966001970 catalytic residue [active] 698966001971 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 698966001972 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 698966001973 dimer interface [polypeptide binding]; other site 698966001974 active site 698966001975 citrylCoA binding site [chemical binding]; other site 698966001976 NADH binding [chemical binding]; other site 698966001977 cationic pore residues; other site 698966001978 oxalacetate/citrate binding site [chemical binding]; other site 698966001979 coenzyme A binding site [chemical binding]; other site 698966001980 catalytic triad [active] 698966001981 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698966001982 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 698966001983 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698966001984 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698966001985 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698966001986 active site 698966001987 catalytic tetrad [active] 698966001988 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 698966001989 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698966001990 substrate binding site [chemical binding]; other site 698966001991 oxyanion hole (OAH) forming residues; other site 698966001992 trimer interface [polypeptide binding]; other site 698966001993 Protein of unknown function, DUF485; Region: DUF485; pfam04341 698966001994 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698966001995 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 698966001996 Na binding site [ion binding]; other site 698966001997 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 698966001998 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 698966001999 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698966002000 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 698966002001 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 698966002002 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698966002003 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 698966002004 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 698966002005 DNA methylase; Region: N6_N4_Mtase; pfam01555 698966002006 DNA methylase; Region: N6_N4_Mtase; pfam01555 698966002007 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698966002008 active site 698966002009 Int/Topo IB signature motif; other site 698966002010 catalytic residues [active] 698966002011 DNA binding site [nucleotide binding] 698966002012 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 698966002013 active site 698966002014 SAM binding site [chemical binding]; other site 698966002015 homodimer interface [polypeptide binding]; other site 698966002016 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698966002017 catalytic residues [active] 698966002018 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 698966002019 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 698966002020 folate binding site [chemical binding]; other site 698966002021 NADP+ binding site [chemical binding]; other site 698966002022 thymidylate synthase; Reviewed; Region: thyA; PRK01827 698966002023 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 698966002024 dimerization interface [polypeptide binding]; other site 698966002025 active site 698966002026 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 698966002027 active site 698966002028 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698966002029 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 698966002030 ATP binding site [chemical binding]; other site 698966002031 putative Mg++ binding site [ion binding]; other site 698966002032 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698966002033 nucleotide binding region [chemical binding]; other site 698966002034 ATP-binding site [chemical binding]; other site 698966002035 DEAD/H associated; Region: DEAD_assoc; pfam08494 698966002036 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 698966002037 active site 698966002038 SUMO-1 interface [polypeptide binding]; other site 698966002039 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698966002040 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 698966002041 putative DNA binding site [nucleotide binding]; other site 698966002042 catalytic residue [active] 698966002043 putative H2TH interface [polypeptide binding]; other site 698966002044 putative catalytic residues [active] 698966002045 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698966002046 Predicted permease [General function prediction only]; Region: COG2985 698966002047 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698966002048 TrkA-C domain; Region: TrkA_C; pfam02080 698966002049 TrkA-C domain; Region: TrkA_C; pfam02080 698966002050 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698966002051 hypothetical protein; Provisional; Region: PRK11770 698966002052 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698966002053 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698966002054 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 698966002055 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 698966002056 active site 698966002057 dimer interface [polypeptide binding]; other site 698966002058 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 698966002059 dimer interface [polypeptide binding]; other site 698966002060 active site 698966002061 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698966002062 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698966002063 tetramerization interface [polypeptide binding]; other site 698966002064 NAD(P) binding site [chemical binding]; other site 698966002065 catalytic residues [active] 698966002066 hypothetical protein; Provisional; Region: PRK07857 698966002067 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 698966002068 Part of AAA domain; Region: AAA_19; pfam13245 698966002069 Family description; Region: UvrD_C_2; pfam13538 698966002070 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698966002071 Peptidase family M23; Region: Peptidase_M23; pfam01551 698966002072 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 698966002073 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 698966002074 active site 698966002075 substrate binding site [chemical binding]; other site 698966002076 cosubstrate binding site; other site 698966002077 catalytic site [active] 698966002078 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 698966002079 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 698966002080 purine monophosphate binding site [chemical binding]; other site 698966002081 dimer interface [polypeptide binding]; other site 698966002082 putative catalytic residues [active] 698966002083 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 698966002084 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698966002085 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 698966002086 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698966002087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698966002088 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 698966002089 30S ribosomal protein S18; Provisional; Region: PRK13401 698966002090 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 698966002091 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 698966002092 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 698966002093 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 698966002094 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 698966002095 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698966002096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698966002097 active site 698966002098 phosphorylation site [posttranslational modification] 698966002099 intermolecular recognition site; other site 698966002100 dimerization interface [polypeptide binding]; other site 698966002101 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698966002102 DNA binding site [nucleotide binding] 698966002103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698966002104 dimerization interface [polypeptide binding]; other site 698966002105 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698966002106 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698966002107 dimer interface [polypeptide binding]; other site 698966002108 phosphorylation site [posttranslational modification] 698966002109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698966002110 ATP binding site [chemical binding]; other site 698966002111 Mg2+ binding site [ion binding]; other site 698966002112 G-X-G motif; other site 698966002113 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698966002114 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698966002115 protein binding site [polypeptide binding]; other site 698966002116 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698966002117 MPT binding site; other site 698966002118 trimer interface [polypeptide binding]; other site 698966002119 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 698966002120 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 698966002121 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 698966002122 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 698966002123 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 698966002124 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 698966002125 active site 698966002126 tetramer interface; other site 698966002127 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698966002128 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698966002129 dimer interface [polypeptide binding]; other site 698966002130 putative functional site; other site 698966002131 putative MPT binding site; other site 698966002132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698966002133 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698966002134 Predicted membrane protein [Function unknown]; Region: COG2259 698966002135 Predicted integral membrane protein [Function unknown]; Region: COG5660 698966002136 Putative zinc-finger; Region: zf-HC2; pfam13490 698966002137 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 698966002138 BCCT family transporter; Region: BCCT; pfam02028 698966002139 Uncharacterized membrane protein [Function unknown]; Region: COG3949 698966002140 Predicted methyltransferases [General function prediction only]; Region: COG0313 698966002141 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 698966002142 putative SAM binding site [chemical binding]; other site 698966002143 putative homodimer interface [polypeptide binding]; other site 698966002144 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 698966002145 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 698966002146 active site 698966002147 HIGH motif; other site 698966002148 KMSKS motif; other site 698966002149 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 698966002150 tRNA binding surface [nucleotide binding]; other site 698966002151 anticodon binding site; other site 698966002152 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 698966002153 active site 698966002154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 698966002155 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698966002156 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698966002157 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698966002158 G5 domain; Region: G5; pfam07501 698966002159 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698966002160 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 698966002161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698966002162 S-adenosylmethionine binding site [chemical binding]; other site 698966002163 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 698966002164 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698966002165 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698966002166 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698966002167 ABC transporter; Region: ABC_tran_2; pfam12848 698966002168 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698966002169 Uncharacterized conserved protein [Function unknown]; Region: COG1359 698966002170 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698966002171 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698966002172 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698966002173 DNA binding residues [nucleotide binding] 698966002174 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698966002175 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 698966002176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698966002177 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698966002178 active site 698966002179 motif I; other site 698966002180 motif II; other site 698966002181 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698966002182 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 698966002183 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698966002184 substrate binding site [chemical binding]; other site 698966002185 oxyanion hole (OAH) forming residues; other site 698966002186 trimer interface [polypeptide binding]; other site 698966002187 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 698966002188 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698966002189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698966002190 potential frameshift: common BLAST hit: gi|38233488|ref|NP_939255.1| glyceraldehyde-3-phosphate dehydrogenase 698966002191 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698966002192 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 698966002193 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698966002194 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 698966002195 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 698966002196 G1 box; other site 698966002197 putative GEF interaction site [polypeptide binding]; other site 698966002198 GTP/Mg2+ binding site [chemical binding]; other site 698966002199 Switch I region; other site 698966002200 G2 box; other site 698966002201 G3 box; other site 698966002202 Switch II region; other site 698966002203 G4 box; other site 698966002204 G5 box; other site 698966002205 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 698966002206 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698966002207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698966002208 NAD(P) binding site [chemical binding]; other site 698966002209 active site 698966002210 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698966002211 putative active site [active] 698966002212 catalytic residue [active] 698966002213 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698966002214 active site 698966002215 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698966002216 putative active site [active] 698966002217 catalytic residue [active] 698966002218 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 698966002219 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 698966002220 5S rRNA interface [nucleotide binding]; other site 698966002221 CTC domain interface [polypeptide binding]; other site 698966002222 L16 interface [polypeptide binding]; other site 698966002223 pullulanase, type I; Region: pulA_typeI; TIGR02104 698966002224 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 698966002225 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 698966002226 Ca binding site [ion binding]; other site 698966002227 active site 698966002228 catalytic site [active] 698966002229 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 698966002230 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 698966002231 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698966002232 active site 698966002233 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 698966002234 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 698966002235 Substrate binding site; other site 698966002236 Mg++ binding site; other site 698966002237 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 698966002238 active site 698966002239 substrate binding site [chemical binding]; other site 698966002240 CoA binding site [chemical binding]; other site 698966002241 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698966002242 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698966002243 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 698966002244 putative dimerization interface [polypeptide binding]; other site 698966002245 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 698966002246 gating phenylalanine in ion channel; other site 698966002247 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 698966002248 putative ligand binding site [chemical binding]; other site 698966002249 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698966002250 putative NAD binding site [chemical binding]; other site 698966002251 catalytic site [active] 698966002252 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698966002253 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698966002254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966002255 Q-loop/lid; other site 698966002256 ABC transporter signature motif; other site 698966002257 Walker B; other site 698966002258 D-loop; other site 698966002259 H-loop/switch region; other site 698966002260 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698966002261 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698966002262 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966002263 Walker A/P-loop; other site 698966002264 ATP binding site [chemical binding]; other site 698966002265 Q-loop/lid; other site 698966002266 ABC transporter signature motif; other site 698966002267 Walker B; other site 698966002268 D-loop; other site 698966002269 H-loop/switch region; other site 698966002270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698966002271 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698966002272 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 698966002273 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 698966002274 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698966002275 ATP binding site [chemical binding]; other site 698966002276 putative Mg++ binding site [ion binding]; other site 698966002277 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698966002278 nucleotide binding region [chemical binding]; other site 698966002279 ATP-binding site [chemical binding]; other site 698966002280 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 698966002281 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 698966002282 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 698966002283 homodimer interface [polypeptide binding]; other site 698966002284 metal binding site [ion binding]; metal-binding site 698966002285 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 698966002286 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698966002287 enolase; Provisional; Region: eno; PRK00077 698966002288 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 698966002289 dimer interface [polypeptide binding]; other site 698966002290 metal binding site [ion binding]; metal-binding site 698966002291 substrate binding pocket [chemical binding]; other site 698966002292 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 698966002293 Septum formation initiator; Region: DivIC; pfam04977 698966002294 Uncharacterized conserved protein [Function unknown]; Region: COG1507 698966002295 exopolyphosphatase; Region: exo_poly_only; TIGR03706 698966002296 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698966002297 Helix-turn-helix domain; Region: HTH_18; pfam12833 698966002298 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698966002299 Bax inhibitor 1 like; Region: BaxI_1; cl17691 698966002300 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 698966002301 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 698966002302 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 698966002303 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 698966002304 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 698966002305 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 698966002306 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698966002307 catalytic residue [active] 698966002308 putative FPP diphosphate binding site; other site 698966002309 putative FPP binding hydrophobic cleft; other site 698966002310 dimer interface [polypeptide binding]; other site 698966002311 putative IPP diphosphate binding site; other site 698966002312 Flavodoxin domain; Region: Flavodoxin_5; cl17428 698966002313 pantothenate kinase; Provisional; Region: PRK05439 698966002314 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 698966002315 ATP-binding site [chemical binding]; other site 698966002316 CoA-binding site [chemical binding]; other site 698966002317 Mg2+-binding site [ion binding]; other site 698966002318 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 698966002319 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 698966002320 dimer interface [polypeptide binding]; other site 698966002321 active site 698966002322 glycine-pyridoxal phosphate binding site [chemical binding]; other site 698966002323 folate binding site [chemical binding]; other site 698966002324 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698966002325 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 698966002326 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698966002327 Coenzyme A binding pocket [chemical binding]; other site 698966002328 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698966002329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966002330 putative substrate translocation pore; other site 698966002331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966002332 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698966002333 fumarate hydratase; Reviewed; Region: fumC; PRK00485 698966002334 Class II fumarases; Region: Fumarase_classII; cd01362 698966002335 active site 698966002336 tetramer interface [polypeptide binding]; other site 698966002337 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 698966002338 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 698966002339 putative active site [active] 698966002340 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 698966002341 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 698966002342 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 698966002343 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 698966002344 generic binding surface II; other site 698966002345 generic binding surface I; other site 698966002346 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 698966002347 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 698966002348 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698966002349 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698966002350 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 698966002351 Na2 binding site [ion binding]; other site 698966002352 putative substrate binding site 1 [chemical binding]; other site 698966002353 Na binding site 1 [ion binding]; other site 698966002354 putative substrate binding site 2 [chemical binding]; other site 698966002355 GTP-binding protein YchF; Reviewed; Region: PRK09601 698966002356 YchF GTPase; Region: YchF; cd01900 698966002357 G1 box; other site 698966002358 GTP/Mg2+ binding site [chemical binding]; other site 698966002359 Switch I region; other site 698966002360 G2 box; other site 698966002361 Switch II region; other site 698966002362 G3 box; other site 698966002363 G4 box; other site 698966002364 G5 box; other site 698966002365 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 698966002366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 698966002367 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 698966002368 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 698966002369 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 698966002370 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 698966002371 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 698966002372 Cl- selectivity filter; other site 698966002373 Cl- binding residues [ion binding]; other site 698966002374 pore gating glutamate residue; other site 698966002375 dimer interface [polypeptide binding]; other site 698966002376 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698966002377 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698966002378 Walker A/P-loop; other site 698966002379 ATP binding site [chemical binding]; other site 698966002380 Q-loop/lid; other site 698966002381 ABC transporter signature motif; other site 698966002382 Walker B; other site 698966002383 D-loop; other site 698966002384 H-loop/switch region; other site 698966002385 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 698966002386 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698966002387 Walker A/P-loop; other site 698966002388 ATP binding site [chemical binding]; other site 698966002389 Q-loop/lid; other site 698966002390 ABC transporter signature motif; other site 698966002391 Walker B; other site 698966002392 D-loop; other site 698966002393 H-loop/switch region; other site 698966002394 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698966002395 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 698966002396 active site 698966002397 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698966002398 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698966002399 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698966002400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698966002401 dimer interface [polypeptide binding]; other site 698966002402 conserved gate region; other site 698966002403 ABC-ATPase subunit interface; other site 698966002404 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698966002405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698966002406 dimer interface [polypeptide binding]; other site 698966002407 conserved gate region; other site 698966002408 putative PBP binding loops; other site 698966002409 ABC-ATPase subunit interface; other site 698966002410 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698966002411 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966002412 Walker A/P-loop; other site 698966002413 ATP binding site [chemical binding]; other site 698966002414 ABC transporter signature motif; other site 698966002415 Walker B; other site 698966002416 D-loop; other site 698966002417 H-loop/switch region; other site 698966002418 Integrase core domain; Region: rve; pfam00665 698966002419 Trypsin; Region: Trypsin; pfam00089 698966002420 active site 698966002421 substrate binding sites [chemical binding]; other site 698966002422 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 698966002423 ArsC family; Region: ArsC; pfam03960 698966002424 catalytic residues [active] 698966002425 Protein of unknown function (DUF402); Region: DUF402; cl00979 698966002426 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 698966002427 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 698966002428 G1 box; other site 698966002429 GTP/Mg2+ binding site [chemical binding]; other site 698966002430 G2 box; other site 698966002431 Switch I region; other site 698966002432 G3 box; other site 698966002433 Switch II region; other site 698966002434 G4 box; other site 698966002435 G5 box; other site 698966002436 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 698966002437 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 698966002438 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 698966002439 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698966002440 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 698966002441 Ferredoxin [Energy production and conversion]; Region: COG1146 698966002442 4Fe-4S binding domain; Region: Fer4; pfam00037 698966002443 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 698966002444 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698966002445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698966002446 homodimer interface [polypeptide binding]; other site 698966002447 catalytic residue [active] 698966002448 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698966002449 active site 698966002450 Predicted membrane protein [Function unknown]; Region: COG2246 698966002451 GtrA-like protein; Region: GtrA; pfam04138 698966002452 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698966002453 active site 698966002454 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 698966002455 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698966002456 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 698966002457 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 698966002458 putative trimer interface [polypeptide binding]; other site 698966002459 putative CoA binding site [chemical binding]; other site 698966002460 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 698966002461 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698966002462 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 698966002463 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698966002464 putative trimer interface [polypeptide binding]; other site 698966002465 putative CoA binding site [chemical binding]; other site 698966002466 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 698966002467 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 698966002468 metal binding site [ion binding]; metal-binding site 698966002469 putative dimer interface [polypeptide binding]; other site 698966002470 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698966002471 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698966002472 dihydropteroate synthase; Region: DHPS; TIGR01496 698966002473 substrate binding pocket [chemical binding]; other site 698966002474 dimer interface [polypeptide binding]; other site 698966002475 inhibitor binding site; inhibition site 698966002476 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 698966002477 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 698966002478 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 698966002479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698966002480 S-adenosylmethionine binding site [chemical binding]; other site 698966002481 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 698966002482 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 698966002483 active site 698966002484 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 698966002485 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 698966002486 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 698966002487 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698966002488 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 698966002489 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 698966002490 ligand binding site; other site 698966002491 oligomer interface; other site 698966002492 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 698966002493 dimer interface [polypeptide binding]; other site 698966002494 N-terminal domain interface [polypeptide binding]; other site 698966002495 sulfate 1 binding site; other site 698966002496 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 698966002497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698966002498 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 698966002499 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698966002500 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698966002501 DNA binding residues [nucleotide binding] 698966002502 Putative zinc-finger; Region: zf-HC2; pfam13490 698966002503 sec-independent translocase; Provisional; Region: tatB; PRK00182 698966002504 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 698966002505 Domain of unknown function DUF59; Region: DUF59; pfam01883 698966002506 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 698966002507 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 698966002508 Predicted membrane protein [Function unknown]; Region: COG4420 698966002509 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 698966002510 MgtE intracellular N domain; Region: MgtE_N; smart00924 698966002511 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 698966002512 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 698966002513 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 698966002514 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698966002515 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 698966002516 TPP-binding site [chemical binding]; other site 698966002517 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 698966002518 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698966002519 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698966002520 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966002521 Walker A/P-loop; other site 698966002522 ATP binding site [chemical binding]; other site 698966002523 Q-loop/lid; other site 698966002524 ABC transporter signature motif; other site 698966002525 Walker B; other site 698966002526 D-loop; other site 698966002527 H-loop/switch region; other site 698966002528 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698966002529 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698966002530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966002531 Walker A/P-loop; other site 698966002532 ATP binding site [chemical binding]; other site 698966002533 Q-loop/lid; other site 698966002534 ABC transporter signature motif; other site 698966002535 Walker B; other site 698966002536 D-loop; other site 698966002537 H-loop/switch region; other site 698966002538 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 698966002539 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698966002540 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698966002541 shikimate binding site; other site 698966002542 NAD(P) binding site [chemical binding]; other site 698966002543 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698966002544 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698966002545 substrate binding pocket [chemical binding]; other site 698966002546 catalytic triad [active] 698966002547 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 698966002548 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 698966002549 active site 698966002550 catalytic residues [active] 698966002551 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698966002552 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 698966002553 Na binding site [ion binding]; other site 698966002554 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698966002555 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 698966002556 nucleotide binding site/active site [active] 698966002557 HIT family signature motif; other site 698966002558 catalytic residue [active] 698966002559 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 698966002560 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698966002561 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698966002562 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698966002563 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 698966002564 PLD-like domain; Region: PLDc_2; pfam13091 698966002565 putative homodimer interface [polypeptide binding]; other site 698966002566 putative active site [active] 698966002567 catalytic site [active] 698966002568 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698966002569 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698966002570 putative Mg++ binding site [ion binding]; other site 698966002571 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698966002572 nucleotide binding region [chemical binding]; other site 698966002573 ATP-binding site [chemical binding]; other site 698966002574 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 698966002575 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 698966002576 active site 698966002577 8-oxo-dGMP binding site [chemical binding]; other site 698966002578 nudix motif; other site 698966002579 metal binding site [ion binding]; metal-binding site 698966002580 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 698966002581 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698966002582 ATP binding site [chemical binding]; other site 698966002583 Mg++ binding site [ion binding]; other site 698966002584 motif III; other site 698966002585 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698966002586 nucleotide binding region [chemical binding]; other site 698966002587 ATP-binding site [chemical binding]; other site 698966002588 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 698966002589 putative RNA binding site [nucleotide binding]; other site 698966002590 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698966002591 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698966002592 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 698966002593 Na binding site [ion binding]; other site 698966002594 SNF2 Helicase protein; Region: DUF3670; pfam12419 698966002595 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 698966002596 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698966002597 ATP binding site [chemical binding]; other site 698966002598 putative Mg++ binding site [ion binding]; other site 698966002599 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698966002600 nucleotide binding region [chemical binding]; other site 698966002601 ATP-binding site [chemical binding]; other site 698966002602 Uncharacterized conserved protein [Function unknown]; Region: COG4279 698966002603 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 698966002604 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 698966002605 active site 698966002606 metal binding site [ion binding]; metal-binding site 698966002607 DNA binding site [nucleotide binding] 698966002608 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 698966002609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966002610 Walker A/P-loop; other site 698966002611 ATP binding site [chemical binding]; other site 698966002612 Q-loop/lid; other site 698966002613 Uncharacterized conserved protein [Function unknown]; Region: COG2353 698966002614 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698966002615 MarR family; Region: MarR_2; pfam12802 698966002616 PspC domain; Region: PspC; cl00864 698966002617 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698966002618 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 698966002619 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698966002620 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 698966002621 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698966002622 Cysteine-rich domain; Region: CCG; pfam02754 698966002623 Cysteine-rich domain; Region: CCG; pfam02754 698966002624 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698966002625 L-lactate permease; Region: Lactate_perm; cl00701 698966002626 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 698966002627 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 698966002628 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 698966002629 active site 698966002630 HIGH motif; other site 698966002631 KMSK motif region; other site 698966002632 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 698966002633 tRNA binding surface [nucleotide binding]; other site 698966002634 anticodon binding site; other site 698966002635 diaminopimelate decarboxylase; Region: lysA; TIGR01048 698966002636 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 698966002637 active site 698966002638 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698966002639 substrate binding site [chemical binding]; other site 698966002640 catalytic residues [active] 698966002641 dimer interface [polypeptide binding]; other site 698966002642 homoserine dehydrogenase; Provisional; Region: PRK06349 698966002643 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 698966002644 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 698966002645 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 698966002646 homoserine kinase; Provisional; Region: PRK01212 698966002647 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 698966002648 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698966002649 acyl-activating enzyme (AAE) consensus motif; other site 698966002650 AMP binding site [chemical binding]; other site 698966002651 active site 698966002652 CoA binding site [chemical binding]; other site 698966002653 transcription termination factor Rho; Provisional; Region: PRK12678 698966002654 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 698966002655 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698966002656 RNA binding site [nucleotide binding]; other site 698966002657 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 698966002658 multimer interface [polypeptide binding]; other site 698966002659 Walker A motif; other site 698966002660 ATP binding site [chemical binding]; other site 698966002661 Walker B motif; other site 698966002662 peptide chain release factor 1; Validated; Region: prfA; PRK00591 698966002663 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698966002664 RF-1 domain; Region: RF-1; pfam00472 698966002665 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 698966002666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698966002667 S-adenosylmethionine binding site [chemical binding]; other site 698966002668 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 698966002669 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 698966002670 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 698966002671 Mg++ binding site [ion binding]; other site 698966002672 putative catalytic motif [active] 698966002673 substrate binding site [chemical binding]; other site 698966002674 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 698966002675 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 698966002676 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 698966002677 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 698966002678 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 698966002679 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 698966002680 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 698966002681 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 698966002682 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698966002683 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 698966002684 beta subunit interaction interface [polypeptide binding]; other site 698966002685 Walker A motif; other site 698966002686 ATP binding site [chemical binding]; other site 698966002687 Walker B motif; other site 698966002688 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698966002689 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 698966002690 core domain interface [polypeptide binding]; other site 698966002691 delta subunit interface [polypeptide binding]; other site 698966002692 epsilon subunit interface [polypeptide binding]; other site 698966002693 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 698966002694 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698966002695 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 698966002696 alpha subunit interaction interface [polypeptide binding]; other site 698966002697 Walker A motif; other site 698966002698 ATP binding site [chemical binding]; other site 698966002699 Walker B motif; other site 698966002700 inhibitor binding site; inhibition site 698966002701 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698966002702 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 698966002703 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 698966002704 gamma subunit interface [polypeptide binding]; other site 698966002705 epsilon subunit interface [polypeptide binding]; other site 698966002706 LBP interface [polypeptide binding]; other site 698966002707 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 698966002708 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 698966002709 hypothetical protein; Provisional; Region: PRK03298 698966002710 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 698966002711 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698966002712 dimer interface [polypeptide binding]; other site 698966002713 substrate binding site [chemical binding]; other site 698966002714 metal binding site [ion binding]; metal-binding site 698966002715 Domain of unknown function DUF77; Region: DUF77; pfam01910 698966002716 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698966002717 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698966002718 Walker A/P-loop; other site 698966002719 ATP binding site [chemical binding]; other site 698966002720 Q-loop/lid; other site 698966002721 ABC transporter signature motif; other site 698966002722 Walker B; other site 698966002723 D-loop; other site 698966002724 H-loop/switch region; other site 698966002725 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698966002726 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698966002727 ABC-ATPase subunit interface; other site 698966002728 dimer interface [polypeptide binding]; other site 698966002729 putative PBP binding regions; other site 698966002730 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698966002731 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698966002732 ABC-ATPase subunit interface; other site 698966002733 dimer interface [polypeptide binding]; other site 698966002734 putative PBP binding regions; other site 698966002735 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 698966002736 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698966002737 siderophore binding site; other site 698966002738 TIGR02611 family protein; Region: TIGR02611 698966002739 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 698966002740 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 698966002741 glycogen branching enzyme; Provisional; Region: PRK05402 698966002742 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 698966002743 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 698966002744 active site 698966002745 catalytic site [active] 698966002746 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 698966002747 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 698966002748 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 698966002749 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698966002750 active site 698966002751 homodimer interface [polypeptide binding]; other site 698966002752 catalytic site [active] 698966002753 acceptor binding site [chemical binding]; other site 698966002754 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698966002755 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966002756 Walker A/P-loop; other site 698966002757 ATP binding site [chemical binding]; other site 698966002758 Q-loop/lid; other site 698966002759 ABC transporter signature motif; other site 698966002760 Walker B; other site 698966002761 D-loop; other site 698966002762 H-loop/switch region; other site 698966002763 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 698966002764 Ligand binding site [chemical binding]; other site 698966002765 Electron transfer flavoprotein domain; Region: ETF; pfam01012 698966002766 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 698966002767 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 698966002768 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 698966002769 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 698966002770 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 698966002771 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698966002772 catalytic residue [active] 698966002773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698966002774 S-adenosylmethionine binding site [chemical binding]; other site 698966002775 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 698966002776 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 698966002777 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698966002778 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698966002779 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698966002780 active site 698966002781 catalytic site [active] 698966002782 substrate binding site [chemical binding]; other site 698966002783 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 698966002784 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 698966002785 nucleotide binding pocket [chemical binding]; other site 698966002786 K-X-D-G motif; other site 698966002787 catalytic site [active] 698966002788 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 698966002789 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 698966002790 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 698966002791 Dimer interface [polypeptide binding]; other site 698966002792 BRCT sequence motif; other site 698966002793 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698966002794 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 698966002795 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698966002796 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 698966002797 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 698966002798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698966002799 Coenzyme A binding pocket [chemical binding]; other site 698966002800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966002801 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698966002802 putative substrate translocation pore; other site 698966002803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966002804 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698966002805 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698966002806 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698966002807 ABC-ATPase subunit interface; other site 698966002808 dimer interface [polypeptide binding]; other site 698966002809 putative PBP binding regions; other site 698966002810 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698966002811 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966002812 Walker A/P-loop; other site 698966002813 ATP binding site [chemical binding]; other site 698966002814 Q-loop/lid; other site 698966002815 ABC transporter signature motif; other site 698966002816 Walker B; other site 698966002817 D-loop; other site 698966002818 H-loop/switch region; other site 698966002819 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 698966002820 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 698966002821 putative ligand binding residues [chemical binding]; other site 698966002822 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 698966002823 phosphofructokinase; Region: PFK_mixed; TIGR02483 698966002824 active site 698966002825 ADP/pyrophosphate binding site [chemical binding]; other site 698966002826 dimerization interface [polypeptide binding]; other site 698966002827 allosteric effector site; other site 698966002828 fructose-1,6-bisphosphate binding site; other site 698966002829 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 698966002830 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 698966002831 GatB domain; Region: GatB_Yqey; smart00845 698966002832 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698966002833 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698966002834 active site 698966002835 catalytic tetrad [active] 698966002836 Lysine efflux permease [General function prediction only]; Region: COG1279 698966002837 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 698966002838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698966002839 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698966002840 dimerization interface [polypeptide binding]; other site 698966002841 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 698966002842 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 698966002843 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 698966002844 putative dimer interface [polypeptide binding]; other site 698966002845 N-terminal domain interface [polypeptide binding]; other site 698966002846 putative substrate binding pocket (H-site) [chemical binding]; other site 698966002847 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698966002848 Predicted membrane protein [Function unknown]; Region: COG2259 698966002849 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 698966002850 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698966002851 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 698966002852 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698966002853 PYR/PP interface [polypeptide binding]; other site 698966002854 dimer interface [polypeptide binding]; other site 698966002855 TPP binding site [chemical binding]; other site 698966002856 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698966002857 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 698966002858 TPP-binding site [chemical binding]; other site 698966002859 dimer interface [polypeptide binding]; other site 698966002860 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 698966002861 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 698966002862 putative valine binding site [chemical binding]; other site 698966002863 dimer interface [polypeptide binding]; other site 698966002864 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 698966002865 ketol-acid reductoisomerase; Provisional; Region: PRK05479 698966002866 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 698966002867 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 698966002868 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 698966002869 Uncharacterized conserved protein [Function unknown]; Region: COG1479 698966002870 Protein of unknown function DUF262; Region: DUF262; pfam03235 698966002871 Uncharacterized conserved protein [Function unknown]; Region: COG3472 698966002872 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 698966002873 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 698966002874 ligand binding site [chemical binding]; other site 698966002875 NAD binding site [chemical binding]; other site 698966002876 dimerization interface [polypeptide binding]; other site 698966002877 catalytic site [active] 698966002878 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 698966002879 putative L-serine binding site [chemical binding]; other site 698966002880 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 698966002881 tartrate dehydrogenase; Region: TTC; TIGR02089 698966002882 potential frameshift: common BLAST hit: gi|62390174|ref|YP_225576.1| signal transduction protein 698966002883 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698966002884 ligand binding site [chemical binding]; other site 698966002885 flexible hinge region; other site 698966002886 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698966002887 potential frameshift: common BLAST hit: gi|62390174|ref|YP_225576.1| signal transduction protein 698966002888 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698966002889 metal binding triad; other site 698966002890 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 698966002891 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698966002892 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698966002893 catalytic site [active] 698966002894 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 698966002895 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 698966002896 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 698966002897 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698966002898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698966002899 S-adenosylmethionine binding site [chemical binding]; other site 698966002900 isochorismate synthase DhbC; Validated; Region: PRK06923 698966002901 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698966002902 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 698966002903 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698966002904 active site 698966002905 HIGH motif; other site 698966002906 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698966002907 active site 698966002908 KMSKS motif; other site 698966002909 Predicted esterase [General function prediction only]; Region: COG0400 698966002910 MMPL family; Region: MMPL; pfam03176 698966002911 Ethanolamine utilisation protein, EutH; Region: EutH; cl01248 698966002912 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698966002913 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698966002914 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698966002915 Cutinase; Region: Cutinase; pfam01083 698966002916 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 698966002917 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 698966002918 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 698966002919 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 698966002920 PhnA protein; Region: PhnA; pfam03831 698966002921 biotin synthase; Region: bioB; TIGR00433 698966002922 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698966002923 FeS/SAM binding site; other site 698966002924 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698966002925 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698966002926 HD domain; Region: HD_4; pfam13328 698966002927 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698966002928 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698966002929 putative DNA binding site [nucleotide binding]; other site 698966002930 putative Zn2+ binding site [ion binding]; other site 698966002931 Bacterial transcriptional regulator; Region: IclR; pfam01614 698966002932 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 698966002933 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 698966002934 substrate binding site [chemical binding]; other site 698966002935 ligand binding site [chemical binding]; other site 698966002936 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 698966002937 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 698966002938 substrate binding site [chemical binding]; other site 698966002939 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698966002940 active site 698966002941 Ap6A binding site [chemical binding]; other site 698966002942 nudix motif; other site 698966002943 metal binding site [ion binding]; metal-binding site 698966002944 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698966002945 catalytic core [active] 698966002946 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 698966002947 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698966002948 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 698966002949 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 698966002950 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 698966002951 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698966002952 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698966002953 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698966002954 thiamine monophosphate kinase; Provisional; Region: PRK05731 698966002955 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 698966002956 ATP binding site [chemical binding]; other site 698966002957 dimerization interface [polypeptide binding]; other site 698966002958 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 698966002959 ligand binding site [chemical binding]; other site 698966002960 active site 698966002961 UGI interface [polypeptide binding]; other site 698966002962 catalytic site [active] 698966002963 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 698966002964 DAK2 domain; Region: Dak2; pfam02734 698966002965 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 698966002966 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 698966002967 generic binding surface II; other site 698966002968 ssDNA binding site; other site 698966002969 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698966002970 ATP binding site [chemical binding]; other site 698966002971 putative Mg++ binding site [ion binding]; other site 698966002972 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698966002973 nucleotide binding region [chemical binding]; other site 698966002974 ATP-binding site [chemical binding]; other site 698966002975 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 698966002976 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698966002977 carboxyltransferase (CT) interaction site; other site 698966002978 biotinylation site [posttranslational modification]; other site 698966002979 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 698966002980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698966002981 S-adenosylmethionine binding site [chemical binding]; other site 698966002982 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 698966002983 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 698966002984 active site 698966002985 (T/H)XGH motif; other site 698966002986 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698966002987 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698966002988 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698966002989 Walker A/P-loop; other site 698966002990 ATP binding site [chemical binding]; other site 698966002991 Q-loop/lid; other site 698966002992 ABC transporter signature motif; other site 698966002993 Walker B; other site 698966002994 D-loop; other site 698966002995 H-loop/switch region; other site 698966002996 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698966002997 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698966002998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698966002999 dimer interface [polypeptide binding]; other site 698966003000 conserved gate region; other site 698966003001 putative PBP binding loops; other site 698966003002 ABC-ATPase subunit interface; other site 698966003003 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698966003004 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698966003005 substrate binding pocket [chemical binding]; other site 698966003006 membrane-bound complex binding site; other site 698966003007 hinge residues; other site 698966003008 Domain of unknown function (DUF368); Region: DUF368; pfam04018 698966003009 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 698966003010 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698966003011 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698966003012 ATP binding site [chemical binding]; other site 698966003013 putative Mg++ binding site [ion binding]; other site 698966003014 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 698966003015 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698966003016 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698966003017 HsdM N-terminal domain; Region: HsdM_N; pfam12161 698966003018 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 698966003019 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698966003020 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698966003021 active site 698966003022 Int/Topo IB signature motif; other site 698966003023 catalytic residues [active] 698966003024 DNA binding site [nucleotide binding] 698966003025 potential frameshift: common BLAST hit: gi|38233440|ref|NP_939207.1| transposase 698966003026 Integrase core domain; Region: rve; pfam00665 698966003027 Integrase core domain; Region: rve_2; pfam13333 698966003028 potential frameshift: common BLAST hit: gi|38233854|ref|NP_939621.1| transposase 698966003029 HTH-like domain; Region: HTH_21; pfam13276 698966003030 Integrase core domain; Region: rve; pfam00665 698966003031 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698966003032 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698966003033 MULE transposase domain; Region: MULE; pfam10551 698966003034 potential frameshift: common BLAST hit: gi|38234527|ref|NP_940294.1| transposase 698966003035 potential frameshift: common BLAST hit: gi|38233952|ref|NP_939719.1| transposase 698966003036 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698966003037 HTH-like domain; Region: HTH_21; pfam13276 698966003038 Integrase core domain; Region: rve; pfam00665 698966003039 Integrase core domain; Region: rve_2; pfam13333 698966003040 MULE transposase domain; Region: MULE; pfam10551 698966003041 DNA polymerase I; Provisional; Region: PRK05755 698966003042 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 698966003043 active site 698966003044 metal binding site 1 [ion binding]; metal-binding site 698966003045 putative 5' ssDNA interaction site; other site 698966003046 metal binding site 3; metal-binding site 698966003047 metal binding site 2 [ion binding]; metal-binding site 698966003048 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 698966003049 putative DNA binding site [nucleotide binding]; other site 698966003050 putative metal binding site [ion binding]; other site 698966003051 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 698966003052 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 698966003053 active site 698966003054 DNA binding site [nucleotide binding] 698966003055 catalytic site [active] 698966003056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698966003057 S-adenosylmethionine binding site [chemical binding]; other site 698966003058 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 698966003059 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 698966003060 RNA binding site [nucleotide binding]; other site 698966003061 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 698966003062 RNA binding site [nucleotide binding]; other site 698966003063 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698966003064 RNA binding site [nucleotide binding]; other site 698966003065 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 698966003066 RNA binding site [nucleotide binding]; other site 698966003067 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 698966003068 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 698966003069 transcriptional antiterminator BglG; Provisional; Region: PRK09772 698966003070 CAT RNA binding domain; Region: CAT_RBD; smart01061 698966003071 PRD domain; Region: PRD; pfam00874 698966003072 PRD domain; Region: PRD; pfam00874 698966003073 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 698966003074 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698966003075 active site turn [active] 698966003076 phosphorylation site [posttranslational modification] 698966003077 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698966003078 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 698966003079 HPr interaction site; other site 698966003080 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698966003081 active site 698966003082 phosphorylation site [posttranslational modification] 698966003083 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 698966003084 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 698966003085 CoA-binding site [chemical binding]; other site 698966003086 ATP-binding [chemical binding]; other site 698966003087 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 698966003088 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698966003089 FeS/SAM binding site; other site 698966003090 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 698966003091 excinuclease ABC subunit B; Provisional; Region: PRK05298 698966003092 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698966003093 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698966003094 nucleotide binding region [chemical binding]; other site 698966003095 ATP-binding site [chemical binding]; other site 698966003096 Ultra-violet resistance protein B; Region: UvrB; pfam12344 698966003097 UvrB/uvrC motif; Region: UVR; pfam02151 698966003098 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698966003099 Ligand Binding Site [chemical binding]; other site 698966003100 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 698966003101 Part of AAA domain; Region: AAA_19; pfam13245 698966003102 PhoH-like protein; Region: PhoH; cl17668 698966003103 Family description; Region: UvrD_C_2; pfam13538 698966003104 Predicted membrane protein [Function unknown]; Region: COG2259 698966003105 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698966003106 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 698966003107 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698966003108 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698966003109 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 698966003110 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 698966003111 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 698966003112 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 698966003113 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 698966003114 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 698966003115 23S rRNA binding site [nucleotide binding]; other site 698966003116 L21 binding site [polypeptide binding]; other site 698966003117 L13 binding site [polypeptide binding]; other site 698966003118 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698966003119 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 698966003120 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698966003121 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 698966003122 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 698966003123 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 698966003124 dimer interface [polypeptide binding]; other site 698966003125 motif 1; other site 698966003126 active site 698966003127 motif 2; other site 698966003128 motif 3; other site 698966003129 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 698966003130 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 698966003131 putative tRNA-binding site [nucleotide binding]; other site 698966003132 B3/4 domain; Region: B3_4; pfam03483 698966003133 tRNA synthetase B5 domain; Region: B5; smart00874 698966003134 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 698966003135 dimer interface [polypeptide binding]; other site 698966003136 motif 1; other site 698966003137 motif 3; other site 698966003138 motif 2; other site 698966003139 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 698966003140 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 698966003141 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698966003142 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 698966003143 heterotetramer interface [polypeptide binding]; other site 698966003144 active site pocket [active] 698966003145 cleavage site 698966003146 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 698966003147 feedback inhibition sensing region; other site 698966003148 homohexameric interface [polypeptide binding]; other site 698966003149 nucleotide binding site [chemical binding]; other site 698966003150 N-acetyl-L-glutamate binding site [chemical binding]; other site 698966003151 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 698966003152 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698966003153 inhibitor-cofactor binding pocket; inhibition site 698966003154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698966003155 catalytic residue [active] 698966003156 ornithine carbamoyltransferase; Provisional; Region: PRK00779 698966003157 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698966003158 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698966003159 arginine repressor; Provisional; Region: PRK03341 698966003160 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 698966003161 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 698966003162 argininosuccinate synthase; Provisional; Region: PRK13820 698966003163 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 698966003164 ANP binding site [chemical binding]; other site 698966003165 Substrate Binding Site II [chemical binding]; other site 698966003166 Substrate Binding Site I [chemical binding]; other site 698966003167 argininosuccinate lyase; Provisional; Region: PRK00855 698966003168 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 698966003169 active sites [active] 698966003170 tetramer interface [polypeptide binding]; other site 698966003171 Uncharacterized conserved protein [Function unknown]; Region: COG2835 698966003172 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 698966003173 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 698966003174 active site 698966003175 HIGH motif; other site 698966003176 dimer interface [polypeptide binding]; other site 698966003177 KMSKS motif; other site 698966003178 S4 RNA-binding domain; Region: S4; smart00363 698966003179 RNA binding surface [nucleotide binding]; other site 698966003180 transcription termination factor Rho; Provisional; Region: PRK12678 698966003181 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698966003182 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698966003183 active site 698966003184 motif I; other site 698966003185 motif II; other site 698966003186 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698966003187 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 698966003188 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698966003189 RNA binding surface [nucleotide binding]; other site 698966003190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698966003191 S-adenosylmethionine binding site [chemical binding]; other site 698966003192 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 698966003193 ATP-NAD kinase; Region: NAD_kinase; pfam01513 698966003194 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 698966003195 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698966003196 Walker A/P-loop; other site 698966003197 ATP binding site [chemical binding]; other site 698966003198 Q-loop/lid; other site 698966003199 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698966003200 ABC transporter signature motif; other site 698966003201 Walker B; other site 698966003202 D-loop; other site 698966003203 H-loop/switch region; other site 698966003204 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 698966003205 Thiamine pyrophosphokinase; Region: TPK; cl08415 698966003206 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 698966003207 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 698966003208 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 698966003209 dimer interface [polypeptide binding]; other site 698966003210 ADP-ribose binding site [chemical binding]; other site 698966003211 active site 698966003212 nudix motif; other site 698966003213 metal binding site [ion binding]; metal-binding site 698966003214 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 698966003215 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 698966003216 active site 698966003217 Int/Topo IB signature motif; other site 698966003218 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698966003219 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698966003220 P-loop; other site 698966003221 Magnesium ion binding site [ion binding]; other site 698966003222 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698966003223 Magnesium ion binding site [ion binding]; other site 698966003224 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 698966003225 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698966003226 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 698966003227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966003228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966003229 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 698966003230 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698966003231 inhibitor-cofactor binding pocket; inhibition site 698966003232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698966003233 catalytic residue [active] 698966003234 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698966003235 AAA domain; Region: AAA_26; pfam13500 698966003236 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 698966003237 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 698966003238 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698966003239 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698966003240 RNA binding surface [nucleotide binding]; other site 698966003241 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 698966003242 active site 698966003243 cytidylate kinase; Provisional; Region: cmk; PRK00023 698966003244 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 698966003245 CMP-binding site; other site 698966003246 The sites determining sugar specificity; other site 698966003247 GTP-binding protein Der; Reviewed; Region: PRK03003 698966003248 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 698966003249 G1 box; other site 698966003250 GTP/Mg2+ binding site [chemical binding]; other site 698966003251 Switch I region; other site 698966003252 G2 box; other site 698966003253 Switch II region; other site 698966003254 G3 box; other site 698966003255 G4 box; other site 698966003256 G5 box; other site 698966003257 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 698966003258 G1 box; other site 698966003259 GTP/Mg2+ binding site [chemical binding]; other site 698966003260 Switch I region; other site 698966003261 G2 box; other site 698966003262 G3 box; other site 698966003263 Switch II region; other site 698966003264 G4 box; other site 698966003265 G5 box; other site 698966003266 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698966003267 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 698966003268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698966003269 S-adenosylmethionine binding site [chemical binding]; other site 698966003270 Putative esterase; Region: Esterase; pfam00756 698966003271 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698966003272 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 698966003273 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698966003274 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 698966003275 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698966003276 nucleotide binding region [chemical binding]; other site 698966003277 ATP-binding site [chemical binding]; other site 698966003278 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698966003279 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698966003280 phosphopeptide binding site; other site 698966003281 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 698966003282 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698966003283 DNA binding residues [nucleotide binding] 698966003284 Bifunctional nuclease; Region: DNase-RNase; pfam02577 698966003285 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 698966003286 DNA binding residues [nucleotide binding] 698966003287 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698966003288 putative dimer interface [polypeptide binding]; other site 698966003289 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698966003290 metal ion-dependent adhesion site (MIDAS); other site 698966003291 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698966003292 Domain of unknown function DUF21; Region: DUF21; pfam01595 698966003293 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698966003294 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698966003295 Domain of unknown function DUF21; Region: DUF21; pfam01595 698966003296 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698966003297 Transporter associated domain; Region: CorC_HlyC; smart01091 698966003298 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 698966003299 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698966003300 ATP binding site [chemical binding]; other site 698966003301 Mg++ binding site [ion binding]; other site 698966003302 motif III; other site 698966003303 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698966003304 nucleotide binding region [chemical binding]; other site 698966003305 ATP-binding site [chemical binding]; other site 698966003306 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698966003307 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 698966003308 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 698966003309 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 698966003310 CoenzymeA binding site [chemical binding]; other site 698966003311 subunit interaction site [polypeptide binding]; other site 698966003312 PHB binding site; other site 698966003313 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 698966003314 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 698966003315 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 698966003316 oligomer interface [polypeptide binding]; other site 698966003317 metal binding site [ion binding]; metal-binding site 698966003318 metal binding site [ion binding]; metal-binding site 698966003319 putative Cl binding site [ion binding]; other site 698966003320 basic sphincter; other site 698966003321 hydrophobic gate; other site 698966003322 periplasmic entrance; other site 698966003323 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698966003324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698966003325 S-adenosylmethionine binding site [chemical binding]; other site 698966003326 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698966003327 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698966003328 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698966003329 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 698966003330 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698966003331 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698966003332 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698966003333 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 698966003334 FAD binding domain; Region: FAD_binding_4; pfam01565 698966003335 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698966003336 Sodium Bile acid symporter family; Region: SBF; pfam01758 698966003337 YceI-like domain; Region: YceI; pfam04264 698966003338 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 698966003339 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 698966003340 Ligand binding site; other site 698966003341 Putative Catalytic site; other site 698966003342 DXD motif; other site 698966003343 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 698966003344 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 698966003345 putative active site [active] 698966003346 catalytic triad [active] 698966003347 putative dimer interface [polypeptide binding]; other site 698966003348 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 698966003349 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 698966003350 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698966003351 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698966003352 precorrin-3B synthase; Region: CobG; TIGR02435 698966003353 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698966003354 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698966003355 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 698966003356 Precorrin-8X methylmutase; Region: CbiC; pfam02570 698966003357 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 698966003358 active site 698966003359 SAM binding site [chemical binding]; other site 698966003360 homodimer interface [polypeptide binding]; other site 698966003361 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 698966003362 active site 698966003363 SAM binding site [chemical binding]; other site 698966003364 homodimer interface [polypeptide binding]; other site 698966003365 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 698966003366 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 698966003367 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 698966003368 active site 698966003369 SAM binding site [chemical binding]; other site 698966003370 homodimer interface [polypeptide binding]; other site 698966003371 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 698966003372 active site 698966003373 putative homodimer interface [polypeptide binding]; other site 698966003374 SAM binding site [chemical binding]; other site 698966003375 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 698966003376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698966003377 S-adenosylmethionine binding site [chemical binding]; other site 698966003378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698966003379 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698966003380 NAD(P) binding site [chemical binding]; other site 698966003381 active site 698966003382 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698966003383 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698966003384 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698966003385 active site 698966003386 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698966003387 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698966003388 ATP binding site [chemical binding]; other site 698966003389 putative Mg++ binding site [ion binding]; other site 698966003390 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698966003391 nucleotide binding region [chemical binding]; other site 698966003392 ATP-binding site [chemical binding]; other site 698966003393 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 698966003394 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 698966003395 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 698966003396 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 698966003397 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 698966003398 Predicted transcriptional regulator [Transcription]; Region: COG2378 698966003399 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 698966003400 WYL domain; Region: WYL; pfam13280 698966003401 WYL domain; Region: WYL; pfam13280 698966003402 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 698966003403 Pup-like protein; Region: Pup; pfam05639 698966003404 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 698966003405 proteasome ATPase; Region: pup_AAA; TIGR03689 698966003406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698966003407 Walker A motif; other site 698966003408 ATP binding site [chemical binding]; other site 698966003409 Walker B motif; other site 698966003410 arginine finger; other site 698966003411 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 698966003412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698966003413 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 698966003414 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 698966003415 active site 698966003416 metal binding site [ion binding]; metal-binding site 698966003417 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 698966003418 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 698966003419 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 698966003420 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 698966003421 Potassium binding sites [ion binding]; other site 698966003422 Cesium cation binding sites [ion binding]; other site 698966003423 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 698966003424 Aspartase; Region: Aspartase; cd01357 698966003425 active sites [active] 698966003426 tetramer interface [polypeptide binding]; other site 698966003427 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698966003428 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 698966003429 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 698966003430 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 698966003431 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 698966003432 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 698966003433 homodimer interface [polypeptide binding]; other site 698966003434 putative metal binding site [ion binding]; other site 698966003435 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 698966003436 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698966003437 motif II; other site 698966003438 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 698966003439 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 698966003440 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 698966003441 substrate binding pocket [chemical binding]; other site 698966003442 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 698966003443 B12 binding site [chemical binding]; other site 698966003444 cobalt ligand [ion binding]; other site 698966003445 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 698966003446 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 698966003447 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698966003448 active site 698966003449 HIGH motif; other site 698966003450 nucleotide binding site [chemical binding]; other site 698966003451 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698966003452 active site 698966003453 KMSKS motif; other site 698966003454 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698966003455 tRNA binding surface [nucleotide binding]; other site 698966003456 anticodon binding site; other site 698966003457 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 698966003458 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 698966003459 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 698966003460 quinone interaction residues [chemical binding]; other site 698966003461 active site 698966003462 catalytic residues [active] 698966003463 FMN binding site [chemical binding]; other site 698966003464 substrate binding site [chemical binding]; other site 698966003465 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 698966003466 substrate binding site [chemical binding]; other site 698966003467 potential frameshift: common BLAST hit: gi|38233854|ref|NP_939621.1| transposase 698966003468 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698966003469 HTH-like domain; Region: HTH_21; pfam13276 698966003470 Integrase core domain; Region: rve; pfam00665 698966003471 Integrase core domain; Region: rve_2; pfam13333 698966003472 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698966003473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698966003474 active site 698966003475 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698966003476 active site residue [active] 698966003477 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698966003478 active site residue [active] 698966003479 membrane ATPase/protein kinase; Provisional; Region: PRK09435 698966003480 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 698966003481 Walker A; other site 698966003482 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 698966003483 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 698966003484 active site 698966003485 substrate binding site [chemical binding]; other site 698966003486 coenzyme B12 binding site [chemical binding]; other site 698966003487 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 698966003488 B12 binding site [chemical binding]; other site 698966003489 cobalt ligand [ion binding]; other site 698966003490 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 698966003491 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 698966003492 heterodimer interface [polypeptide binding]; other site 698966003493 substrate interaction site [chemical binding]; other site 698966003494 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 698966003495 Uncharacterized conserved protein [Function unknown]; Region: COG0398 698966003496 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 698966003497 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698966003498 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 698966003499 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 698966003500 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 698966003501 ferrochelatase; Reviewed; Region: hemH; PRK00035 698966003502 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 698966003503 C-terminal domain interface [polypeptide binding]; other site 698966003504 active site 698966003505 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 698966003506 active site 698966003507 N-terminal domain interface [polypeptide binding]; other site 698966003508 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698966003509 NlpC/P60 family; Region: NLPC_P60; pfam00877 698966003510 aconitate hydratase; Validated; Region: PRK09277 698966003511 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698966003512 substrate binding site [chemical binding]; other site 698966003513 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698966003514 ligand binding site [chemical binding]; other site 698966003515 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 698966003516 substrate binding site [chemical binding]; other site 698966003517 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698966003518 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698966003519 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 698966003520 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 698966003521 catalytic triad [active] 698966003522 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 698966003523 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 698966003524 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698966003525 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698966003526 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966003527 Walker A/P-loop; other site 698966003528 ATP binding site [chemical binding]; other site 698966003529 Q-loop/lid; other site 698966003530 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698966003531 ABC transporter signature motif; other site 698966003532 Walker B; other site 698966003533 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698966003534 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 698966003535 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 698966003536 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 698966003537 trimerization site [polypeptide binding]; other site 698966003538 active site 698966003539 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698966003540 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 698966003541 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698966003542 catalytic residue [active] 698966003543 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 698966003544 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 698966003545 Walker A/P-loop; other site 698966003546 ATP binding site [chemical binding]; other site 698966003547 Q-loop/lid; other site 698966003548 ABC transporter signature motif; other site 698966003549 Walker B; other site 698966003550 D-loop; other site 698966003551 H-loop/switch region; other site 698966003552 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 698966003553 FeS assembly protein SufD; Region: sufD; TIGR01981 698966003554 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 698966003555 FeS assembly protein SufB; Region: sufB; TIGR01980 698966003556 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698966003557 Predicted transcriptional regulator [Transcription]; Region: COG2345 698966003558 putative DNA binding site [nucleotide binding]; other site 698966003559 putative Zn2+ binding site [ion binding]; other site 698966003560 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698966003561 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698966003562 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698966003563 Walker A/P-loop; other site 698966003564 ATP binding site [chemical binding]; other site 698966003565 Q-loop/lid; other site 698966003566 ABC transporter signature motif; other site 698966003567 Walker B; other site 698966003568 D-loop; other site 698966003569 H-loop/switch region; other site 698966003570 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698966003571 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698966003572 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 698966003573 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 698966003574 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 698966003575 UbiA prenyltransferase family; Region: UbiA; pfam01040 698966003576 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 698966003577 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 698966003578 TPP-binding site [chemical binding]; other site 698966003579 dimer interface [polypeptide binding]; other site 698966003580 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698966003581 PYR/PP interface [polypeptide binding]; other site 698966003582 dimer interface [polypeptide binding]; other site 698966003583 TPP binding site [chemical binding]; other site 698966003584 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698966003585 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 698966003586 putative active site [active] 698966003587 transaldolase; Provisional; Region: PRK03903 698966003588 catalytic residue [active] 698966003589 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 698966003590 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 698966003591 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 698966003592 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 698966003593 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 698966003594 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698966003595 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 698966003596 putative active site [active] 698966003597 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 698966003598 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 698966003599 triosephosphate isomerase; Provisional; Region: PRK14567 698966003600 substrate binding site [chemical binding]; other site 698966003601 dimer interface [polypeptide binding]; other site 698966003602 catalytic triad [active] 698966003603 Phosphoglycerate kinase; Region: PGK; pfam00162 698966003604 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 698966003605 substrate binding site [chemical binding]; other site 698966003606 hinge regions; other site 698966003607 ADP binding site [chemical binding]; other site 698966003608 catalytic site [active] 698966003609 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 698966003610 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 698966003611 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698966003612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 698966003613 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 698966003614 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 698966003615 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 698966003616 phosphate binding site [ion binding]; other site 698966003617 putative substrate binding pocket [chemical binding]; other site 698966003618 dimer interface [polypeptide binding]; other site 698966003619 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 698966003620 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 698966003621 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 698966003622 GIY-YIG motif/motif A; other site 698966003623 active site 698966003624 catalytic site [active] 698966003625 putative DNA binding site [nucleotide binding]; other site 698966003626 metal binding site [ion binding]; metal-binding site 698966003627 UvrB/uvrC motif; Region: UVR; pfam02151 698966003628 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 698966003629 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698966003630 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 698966003631 homopentamer interface [polypeptide binding]; other site 698966003632 active site 698966003633 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 698966003634 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 698966003635 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 698966003636 dimerization interface [polypeptide binding]; other site 698966003637 active site 698966003638 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 698966003639 Lumazine binding domain; Region: Lum_binding; pfam00677 698966003640 Lumazine binding domain; Region: Lum_binding; pfam00677 698966003641 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 698966003642 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 698966003643 catalytic motif [active] 698966003644 Zn binding site [ion binding]; other site 698966003645 RibD C-terminal domain; Region: RibD_C; pfam01872 698966003646 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 698966003647 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 698966003648 substrate binding site [chemical binding]; other site 698966003649 hexamer interface [polypeptide binding]; other site 698966003650 metal binding site [ion binding]; metal-binding site 698966003651 16S rRNA methyltransferase B; Provisional; Region: PRK14902 698966003652 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 698966003653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698966003654 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 698966003655 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 698966003656 putative active site [active] 698966003657 substrate binding site [chemical binding]; other site 698966003658 putative cosubstrate binding site; other site 698966003659 catalytic site [active] 698966003660 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 698966003661 substrate binding site [chemical binding]; other site 698966003662 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698966003663 active site 698966003664 catalytic residues [active] 698966003665 metal binding site [ion binding]; metal-binding site 698966003666 primosome assembly protein PriA; Provisional; Region: PRK14873 698966003667 S-adenosylmethionine synthetase; Validated; Region: PRK05250 698966003668 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 698966003669 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 698966003670 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 698966003671 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 698966003672 Flavoprotein; Region: Flavoprotein; pfam02441 698966003673 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 698966003674 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 698966003675 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 698966003676 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 698966003677 catalytic site [active] 698966003678 G-X2-G-X-G-K; other site 698966003679 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 698966003680 active site 698966003681 dimer interface [polypeptide binding]; other site 698966003682 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 698966003683 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698966003684 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698966003685 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 698966003686 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698966003687 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698966003688 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 698966003689 IMP binding site; other site 698966003690 dimer interface [polypeptide binding]; other site 698966003691 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 698966003692 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 698966003693 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 698966003694 catalytic site [active] 698966003695 subunit interface [polypeptide binding]; other site 698966003696 dihydroorotase; Validated; Region: pyrC; PRK09357 698966003697 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698966003698 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 698966003699 active site 698966003700 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 698966003701 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698966003702 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698966003703 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 698966003704 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698966003705 active site 698966003706 hydrophobic ligand binding site; other site 698966003707 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698966003708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698966003709 TIGR01777 family protein; Region: yfcH 698966003710 NAD(P) binding site [chemical binding]; other site 698966003711 active site 698966003712 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 698966003713 elongation factor P; Validated; Region: PRK00529 698966003714 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 698966003715 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 698966003716 RNA binding site [nucleotide binding]; other site 698966003717 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 698966003718 RNA binding site [nucleotide binding]; other site 698966003719 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698966003720 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698966003721 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698966003722 active site 698966003723 Dehydroquinase class II; Region: DHquinase_II; pfam01220 698966003724 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 698966003725 trimer interface [polypeptide binding]; other site 698966003726 active site 698966003727 dimer interface [polypeptide binding]; other site 698966003728 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 698966003729 active site 698966003730 dimer interface [polypeptide binding]; other site 698966003731 metal binding site [ion binding]; metal-binding site 698966003732 shikimate kinase; Reviewed; Region: aroK; PRK00131 698966003733 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 698966003734 ADP binding site [chemical binding]; other site 698966003735 magnesium binding site [ion binding]; other site 698966003736 putative shikimate binding site; other site 698966003737 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 698966003738 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 698966003739 Tetramer interface [polypeptide binding]; other site 698966003740 active site 698966003741 FMN-binding site [chemical binding]; other site 698966003742 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 698966003743 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698966003744 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698966003745 shikimate binding site; other site 698966003746 NAD(P) binding site [chemical binding]; other site 698966003747 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 698966003748 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 698966003749 dimerization interface [polypeptide binding]; other site 698966003750 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 698966003751 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 698966003752 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 698966003753 motif 1; other site 698966003754 active site 698966003755 motif 2; other site 698966003756 motif 3; other site 698966003757 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698966003758 DHHA1 domain; Region: DHHA1; pfam02272 698966003759 recombination factor protein RarA; Reviewed; Region: PRK13342 698966003760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698966003761 Walker A motif; other site 698966003762 ATP binding site [chemical binding]; other site 698966003763 Walker B motif; other site 698966003764 arginine finger; other site 698966003765 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 698966003766 Phosphotransferase enzyme family; Region: APH; pfam01636 698966003767 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698966003768 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 698966003769 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 698966003770 dimer interface [polypeptide binding]; other site 698966003771 anticodon binding site; other site 698966003772 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 698966003773 homodimer interface [polypeptide binding]; other site 698966003774 motif 1; other site 698966003775 active site 698966003776 motif 2; other site 698966003777 GAD domain; Region: GAD; pfam02938 698966003778 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698966003779 active site 698966003780 motif 3; other site 698966003781 Predicted metalloprotease [General function prediction only]; Region: COG2321 698966003782 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 698966003783 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698966003784 ATP binding site [chemical binding]; other site 698966003785 putative Mg++ binding site [ion binding]; other site 698966003786 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698966003787 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 698966003788 nucleotide binding region [chemical binding]; other site 698966003789 ATP-binding site [chemical binding]; other site 698966003790 Predicted membrane protein [Function unknown]; Region: COG1511 698966003791 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698966003792 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698966003793 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698966003794 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698966003795 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698966003796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966003797 Q-loop/lid; other site 698966003798 ABC transporter signature motif; other site 698966003799 Walker B; other site 698966003800 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698966003801 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698966003802 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 698966003803 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 698966003804 dimer interface [polypeptide binding]; other site 698966003805 motif 1; other site 698966003806 active site 698966003807 motif 2; other site 698966003808 motif 3; other site 698966003809 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 698966003810 anticodon binding site; other site 698966003811 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698966003812 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 698966003813 dimer interface [polypeptide binding]; other site 698966003814 catalytic triad [active] 698966003815 peroxidatic and resolving cysteines [active] 698966003816 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698966003817 active site 698966003818 MULE transposase domain; Region: MULE; pfam10551 698966003819 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698966003820 MULE transposase domain; Region: MULE; pfam10551 698966003821 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698966003822 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698966003823 Zn2+ binding site [ion binding]; other site 698966003824 Mg2+ binding site [ion binding]; other site 698966003825 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698966003826 synthetase active site [active] 698966003827 NTP binding site [chemical binding]; other site 698966003828 metal binding site [ion binding]; metal-binding site 698966003829 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 698966003830 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 698966003831 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698966003832 active site 698966003833 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 698966003834 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698966003835 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 698966003836 Protein export membrane protein; Region: SecD_SecF; cl14618 698966003837 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 698966003838 Protein export membrane protein; Region: SecD_SecF; cl14618 698966003839 Preprotein translocase subunit; Region: YajC; pfam02699 698966003840 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 698966003841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698966003842 Walker A motif; other site 698966003843 ATP binding site [chemical binding]; other site 698966003844 Walker B motif; other site 698966003845 arginine finger; other site 698966003846 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 698966003847 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 698966003848 RuvA N terminal domain; Region: RuvA_N; pfam01330 698966003849 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 698966003850 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 698966003851 active site 698966003852 putative DNA-binding cleft [nucleotide binding]; other site 698966003853 dimer interface [polypeptide binding]; other site 698966003854 hypothetical protein; Validated; Region: PRK00110 698966003855 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 698966003856 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 698966003857 active site 698966003858 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 698966003859 catalytic triad [active] 698966003860 dimer interface [polypeptide binding]; other site 698966003861 Integrase core domain; Region: rve; pfam00665 698966003862 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698966003863 Helix-turn-helix domain; Region: HTH_38; pfam13936 698966003864 Integrase core domain; Region: rve; pfam00665 698966003865 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 698966003866 FMN binding site [chemical binding]; other site 698966003867 substrate binding site [chemical binding]; other site 698966003868 putative catalytic residue [active] 698966003869 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 698966003870 Replicase family; Region: Replicase; pfam03090 698966003871 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 698966003872 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698966003873 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698966003874 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698966003875 catalytic residues [active] 698966003876 catalytic nucleophile [active] 698966003877 Presynaptic Site I dimer interface [polypeptide binding]; other site 698966003878 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698966003879 Synaptic Flat tetramer interface [polypeptide binding]; other site 698966003880 Synaptic Site I dimer interface [polypeptide binding]; other site 698966003881 DNA binding site [nucleotide binding] 698966003882 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698966003883 MULE transposase domain; Region: MULE; pfam10551 698966003884 potential frameshift: common BLAST hit: gi|68536874|ref|YP_251579.1| transposase IS3525 698966003885 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698966003886 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698966003887 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698966003888 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 698966003889 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 698966003890 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698966003891 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698966003892 catalytic residue [active] 698966003893 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698966003894 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698966003895 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 698966003896 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 698966003897 putative acyl-acceptor binding pocket; other site 698966003898 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698966003899 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 698966003900 nucleotide binding site/active site [active] 698966003901 HIT family signature motif; other site 698966003902 catalytic residue [active] 698966003903 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 698966003904 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698966003905 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 698966003906 active site 698966003907 dimer interface [polypeptide binding]; other site 698966003908 motif 1; other site 698966003909 motif 2; other site 698966003910 motif 3; other site 698966003911 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 698966003912 anticodon binding site; other site 698966003913 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 698966003914 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 698966003915 Protein of unknown function (DUF461); Region: DUF461; pfam04314 698966003916 CopC domain; Region: CopC; cl01012 698966003917 HTH-like domain; Region: HTH_21; pfam13276 698966003918 Integrase core domain; Region: rve; pfam00665 698966003919 Integrase core domain; Region: rve_2; pfam13333 698966003920 hypothetical protein; Provisional; Region: PRK14059 698966003921 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 698966003922 SelR domain; Region: SelR; pfam01641 698966003923 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 698966003924 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 698966003925 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 698966003926 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 698966003927 catalytic site [active] 698966003928 putative active site [active] 698966003929 putative substrate binding site [chemical binding]; other site 698966003930 HRDC domain; Region: HRDC; pfam00570 698966003931 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 698966003932 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 698966003933 TPP-binding site; other site 698966003934 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698966003935 PYR/PP interface [polypeptide binding]; other site 698966003936 dimer interface [polypeptide binding]; other site 698966003937 TPP binding site [chemical binding]; other site 698966003938 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698966003939 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 698966003940 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 698966003941 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 698966003942 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698966003943 trimer interface [polypeptide binding]; other site 698966003944 active site 698966003945 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 698966003946 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 698966003947 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698966003948 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 698966003949 active site 698966003950 dimerization interface [polypeptide binding]; other site 698966003951 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698966003952 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698966003953 nucleotide binding site [chemical binding]; other site 698966003954 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698966003955 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698966003956 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698966003957 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698966003958 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698966003959 DNA binding residues [nucleotide binding] 698966003960 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698966003961 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698966003962 ATP binding site [chemical binding]; other site 698966003963 putative Mg++ binding site [ion binding]; other site 698966003964 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 698966003965 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 698966003966 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 698966003967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698966003968 S-adenosylmethionine binding site [chemical binding]; other site 698966003969 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 698966003970 putative active site [active] 698966003971 dimerization interface [polypeptide binding]; other site 698966003972 putative tRNAtyr binding site [nucleotide binding]; other site 698966003973 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698966003974 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698966003975 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698966003976 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698966003977 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698966003978 DNA binding residues [nucleotide binding] 698966003979 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698966003980 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698966003981 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698966003982 FeoA domain; Region: FeoA; cl00838 698966003983 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 698966003984 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 698966003985 NAD binding site [chemical binding]; other site 698966003986 homodimer interface [polypeptide binding]; other site 698966003987 active site 698966003988 substrate binding site [chemical binding]; other site 698966003989 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 698966003990 PAC2 family; Region: PAC2; pfam09754 698966003991 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698966003992 ATP binding site [chemical binding]; other site 698966003993 putative Mg++ binding site [ion binding]; other site 698966003994 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698966003995 nucleotide binding region [chemical binding]; other site 698966003996 ATP-binding site [chemical binding]; other site 698966003997 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 698966003998 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 698966003999 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 698966004000 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698966004001 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 698966004002 dimer interface [polypeptide binding]; other site 698966004003 decamer (pentamer of dimers) interface [polypeptide binding]; other site 698966004004 catalytic triad [active] 698966004005 peroxidatic and resolving cysteines [active] 698966004006 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698966004007 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 698966004008 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 698966004009 dimerization interface [polypeptide binding]; other site 698966004010 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 698966004011 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698966004012 ATP binding site [chemical binding]; other site 698966004013 putative Mg++ binding site [ion binding]; other site 698966004014 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698966004015 nucleotide binding region [chemical binding]; other site 698966004016 ATP-binding site [chemical binding]; other site 698966004017 Helicase associated domain (HA2); Region: HA2; pfam04408 698966004018 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 698966004019 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 698966004020 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 698966004021 ATP cone domain; Region: ATP-cone; pfam03477 698966004022 LexA repressor; Validated; Region: PRK00215 698966004023 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 698966004024 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698966004025 Catalytic site [active] 698966004026 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698966004027 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 698966004028 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698966004029 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 698966004030 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 698966004031 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 698966004032 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 698966004033 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698966004034 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698966004035 DNA-binding site [nucleotide binding]; DNA binding site 698966004036 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698966004037 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 698966004038 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 698966004039 putative substrate binding site [chemical binding]; other site 698966004040 putative ATP binding site [chemical binding]; other site 698966004041 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698966004042 dimerization domain swap beta strand [polypeptide binding]; other site 698966004043 regulatory protein interface [polypeptide binding]; other site 698966004044 active site 698966004045 regulatory phosphorylation site [posttranslational modification]; other site 698966004046 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 698966004047 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698966004048 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 698966004049 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698966004050 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 698966004051 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 698966004052 GTPases [General function prediction only]; Region: HflX; COG2262 698966004053 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 698966004054 HflX GTPase family; Region: HflX; cd01878 698966004055 G1 box; other site 698966004056 GTP/Mg2+ binding site [chemical binding]; other site 698966004057 Switch I region; other site 698966004058 G2 box; other site 698966004059 G3 box; other site 698966004060 Switch II region; other site 698966004061 G4 box; other site 698966004062 G5 box; other site 698966004063 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 698966004064 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698966004065 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698966004066 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 698966004067 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 698966004068 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698966004069 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698966004070 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698966004071 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698966004072 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 698966004073 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 698966004074 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698966004075 FeS/SAM binding site; other site 698966004076 recombination regulator RecX; Reviewed; Region: recX; PRK00117 698966004077 recombinase A; Provisional; Region: recA; PRK09354 698966004078 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 698966004079 hexamer interface [polypeptide binding]; other site 698966004080 Walker A motif; other site 698966004081 ATP binding site [chemical binding]; other site 698966004082 Walker B motif; other site 698966004083 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 698966004084 BioY family; Region: BioY; pfam02632 698966004085 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698966004086 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698966004087 Walker A/P-loop; other site 698966004088 ATP binding site [chemical binding]; other site 698966004089 Q-loop/lid; other site 698966004090 ABC transporter signature motif; other site 698966004091 Walker B; other site 698966004092 D-loop; other site 698966004093 H-loop/switch region; other site 698966004094 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698966004095 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698966004096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698966004097 sequence-specific DNA binding site [nucleotide binding]; other site 698966004098 salt bridge; other site 698966004099 Competence-damaged protein; Region: CinA; pfam02464 698966004100 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698966004101 YCII-related domain; Region: YCII; cl00999 698966004102 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 698966004103 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 698966004104 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698966004105 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 698966004106 TIGR03085 family protein; Region: TIGR03085 698966004107 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 698966004108 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698966004109 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 698966004110 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 698966004111 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698966004112 dimer interface [polypeptide binding]; other site 698966004113 active site 698966004114 catalytic residue [active] 698966004115 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 698966004116 dihydrodipicolinate reductase; Provisional; Region: PRK00048 698966004117 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 698966004118 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 698966004119 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 698966004120 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 698966004121 oligomer interface [polypeptide binding]; other site 698966004122 RNA binding site [nucleotide binding]; other site 698966004123 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 698966004124 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 698966004125 RNase E interface [polypeptide binding]; other site 698966004126 trimer interface [polypeptide binding]; other site 698966004127 active site 698966004128 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 698966004129 putative nucleic acid binding region [nucleotide binding]; other site 698966004130 G-X-X-G motif; other site 698966004131 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 698966004132 RNA binding site [nucleotide binding]; other site 698966004133 domain interface; other site 698966004134 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 698966004135 16S/18S rRNA binding site [nucleotide binding]; other site 698966004136 S13e-L30e interaction site [polypeptide binding]; other site 698966004137 25S rRNA binding site [nucleotide binding]; other site 698966004138 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 698966004139 active site 698966004140 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 698966004141 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 698966004142 active site 698966004143 Riboflavin kinase; Region: Flavokinase; smart00904 698966004144 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 698966004145 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 698966004146 RNA binding site [nucleotide binding]; other site 698966004147 active site 698966004148 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 698966004149 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 698966004150 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 698966004151 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698966004152 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698966004153 active site 698966004154 metal binding site [ion binding]; metal-binding site 698966004155 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698966004156 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 698966004157 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 698966004158 DHH family; Region: DHH; pfam01368 698966004159 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 698966004160 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698966004161 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698966004162 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 698966004163 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 698966004164 G1 box; other site 698966004165 putative GEF interaction site [polypeptide binding]; other site 698966004166 GTP/Mg2+ binding site [chemical binding]; other site 698966004167 Switch I region; other site 698966004168 G2 box; other site 698966004169 G3 box; other site 698966004170 Switch II region; other site 698966004171 G4 box; other site 698966004172 G5 box; other site 698966004173 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 698966004174 Translation-initiation factor 2; Region: IF-2; pfam11987 698966004175 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 698966004176 Protein of unknown function (DUF448); Region: DUF448; pfam04296 698966004177 putative RNA binding cleft [nucleotide binding]; other site 698966004178 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 698966004179 NusA N-terminal domain; Region: NusA_N; pfam08529 698966004180 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 698966004181 RNA binding site [nucleotide binding]; other site 698966004182 homodimer interface [polypeptide binding]; other site 698966004183 NusA-like KH domain; Region: KH_5; pfam13184 698966004184 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 698966004185 G-X-X-G motif; other site 698966004186 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 698966004187 Sm and related proteins; Region: Sm_like; cl00259 698966004188 prolyl-tRNA synthetase; Provisional; Region: PRK09194 698966004189 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 698966004190 dimer interface [polypeptide binding]; other site 698966004191 motif 1; other site 698966004192 active site 698966004193 motif 2; other site 698966004194 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 698966004195 putative deacylase active site [active] 698966004196 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698966004197 active site 698966004198 motif 3; other site 698966004199 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 698966004200 anticodon binding site; other site 698966004201 hypothetical protein; Validated; Region: PRK02101 698966004202 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 698966004203 active site 698966004204 SAM binding site [chemical binding]; other site 698966004205 homodimer interface [polypeptide binding]; other site 698966004206 Uncharacterized conserved protein [Function unknown]; Region: COG0397 698966004207 hypothetical protein; Validated; Region: PRK00029 698966004208 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698966004209 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 698966004210 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 698966004211 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 698966004212 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698966004213 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 698966004214 catalytic triad [active] 698966004215 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 698966004216 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 698966004217 Walker A motif; other site 698966004218 homodimer interface [polypeptide binding]; other site 698966004219 ATP binding site [chemical binding]; other site 698966004220 hydroxycobalamin binding site [chemical binding]; other site 698966004221 Walker B motif; other site 698966004222 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 698966004223 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 698966004224 metal ion-dependent adhesion site (MIDAS); other site 698966004225 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 698966004226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698966004227 Walker A motif; other site 698966004228 ATP binding site [chemical binding]; other site 698966004229 Walker B motif; other site 698966004230 arginine finger; other site 698966004231 malate:quinone oxidoreductase; Validated; Region: PRK05257 698966004232 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 698966004233 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698966004234 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698966004235 mycothione reductase; Region: mycothione_red; TIGR03452 698966004236 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698966004237 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698966004238 cobyric acid synthase; Provisional; Region: PRK00784 698966004239 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 698966004240 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698966004241 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698966004242 catalytic triad [active] 698966004243 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698966004244 active site 698966004245 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 698966004246 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698966004247 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 698966004248 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698966004249 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698966004250 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 698966004251 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698966004252 active site 698966004253 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 698966004254 protein binding site [polypeptide binding]; other site 698966004255 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 698966004256 putative substrate binding region [chemical binding]; other site 698966004257 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 698966004258 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 698966004259 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 698966004260 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 698966004261 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 698966004262 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 698966004263 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698966004264 FeS/SAM binding site; other site 698966004265 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 698966004266 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 698966004267 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 698966004268 ribosome recycling factor; Reviewed; Region: frr; PRK00083 698966004269 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 698966004270 hinge region; other site 698966004271 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 698966004272 putative nucleotide binding site [chemical binding]; other site 698966004273 uridine monophosphate binding site [chemical binding]; other site 698966004274 homohexameric interface [polypeptide binding]; other site 698966004275 elongation factor Ts; Provisional; Region: tsf; PRK09377 698966004276 UBA/TS-N domain; Region: UBA; pfam00627 698966004277 Elongation factor TS; Region: EF_TS; pfam00889 698966004278 Elongation factor TS; Region: EF_TS; pfam00889 698966004279 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 698966004280 rRNA interaction site [nucleotide binding]; other site 698966004281 S8 interaction site; other site 698966004282 putative laminin-1 binding site; other site 698966004283 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698966004284 Peptidase family M23; Region: Peptidase_M23; pfam01551 698966004285 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698966004286 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 698966004287 active site 698966004288 DNA binding site [nucleotide binding] 698966004289 Int/Topo IB signature motif; other site 698966004290 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 698966004291 DNA protecting protein DprA; Region: dprA; TIGR00732 698966004292 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 698966004293 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698966004294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698966004295 Walker A motif; other site 698966004296 ATP binding site [chemical binding]; other site 698966004297 Walker B motif; other site 698966004298 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 698966004299 hypothetical protein; Reviewed; Region: PRK12497 698966004300 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 698966004301 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 698966004302 RNA/DNA hybrid binding site [nucleotide binding]; other site 698966004303 active site 698966004304 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 698966004305 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698966004306 Catalytic site [active] 698966004307 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698966004308 Htaa; Region: HtaA; pfam04213 698966004309 Htaa; Region: HtaA; pfam04213 698966004310 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 698966004311 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 698966004312 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 698966004313 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 698966004314 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698966004315 RNA binding site [nucleotide binding]; other site 698966004316 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 698966004317 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 698966004318 RimM N-terminal domain; Region: RimM; pfam01782 698966004319 PRC-barrel domain; Region: PRC; pfam05239 698966004320 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 698966004321 signal recognition particle protein; Provisional; Region: PRK10867 698966004322 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 698966004323 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 698966004324 P loop; other site 698966004325 GTP binding site [chemical binding]; other site 698966004326 Signal peptide binding domain; Region: SRP_SPB; pfam02978 698966004327 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 698966004328 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698966004329 metal binding triad; other site 698966004330 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698966004331 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 698966004332 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 698966004333 Nitrogen regulatory protein P-II; Region: P-II; smart00938 698966004334 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 698966004335 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 698966004336 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698966004337 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 698966004338 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698966004339 Walker A/P-loop; other site 698966004340 ATP binding site [chemical binding]; other site 698966004341 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 698966004342 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698966004343 ABC transporter signature motif; other site 698966004344 Walker B; other site 698966004345 D-loop; other site 698966004346 H-loop/switch region; other site 698966004347 Acylphosphatase; Region: Acylphosphatase; cl00551 698966004348 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698966004349 amino acid carrier protein; Region: agcS; TIGR00835 698966004350 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 698966004351 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 698966004352 DNA binding site [nucleotide binding] 698966004353 catalytic residue [active] 698966004354 H2TH interface [polypeptide binding]; other site 698966004355 putative catalytic residues [active] 698966004356 turnover-facilitating residue; other site 698966004357 intercalation triad [nucleotide binding]; other site 698966004358 8OG recognition residue [nucleotide binding]; other site 698966004359 putative reading head residues; other site 698966004360 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698966004361 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698966004362 ribonuclease III; Reviewed; Region: rnc; PRK00102 698966004363 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 698966004364 dimerization interface [polypeptide binding]; other site 698966004365 active site 698966004366 metal binding site [ion binding]; metal-binding site 698966004367 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 698966004368 dsRNA binding site [nucleotide binding]; other site 698966004369 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 698966004370 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698966004371 glutamate dehydrogenase; Provisional; Region: PRK09414 698966004372 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 698966004373 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 698966004374 NAD(P) binding site [chemical binding]; other site 698966004375 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 698966004376 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698966004377 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698966004378 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 698966004379 metal binding site [ion binding]; metal-binding site 698966004380 putative dimer interface [polypeptide binding]; other site 698966004381 pyruvate kinase; Provisional; Region: PRK06247 698966004382 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 698966004383 domain interfaces; other site 698966004384 active site 698966004385 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 698966004386 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698966004387 active site 698966004388 ribulose/triose binding site [chemical binding]; other site 698966004389 phosphate binding site [ion binding]; other site 698966004390 substrate (anthranilate) binding pocket [chemical binding]; other site 698966004391 product (indole) binding pocket [chemical binding]; other site 698966004392 trp region conserved hypothetical membrane protein; Region: trp_oprn_chp; TIGR02234 698966004393 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 698966004394 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 698966004395 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698966004396 substrate binding site [chemical binding]; other site 698966004397 glutamase interaction surface [polypeptide binding]; other site 698966004398 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698966004399 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698966004400 active site 698966004401 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 698966004402 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698966004403 catalytic residues [active] 698966004404 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 698966004405 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 698966004406 putative active site [active] 698966004407 oxyanion strand; other site 698966004408 catalytic triad [active] 698966004409 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698966004410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966004411 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 698966004412 putative active site pocket [active] 698966004413 4-fold oligomerization interface [polypeptide binding]; other site 698966004414 metal binding residues [ion binding]; metal-binding site 698966004415 3-fold/trimer interface [polypeptide binding]; other site 698966004416 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 698966004417 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698966004418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698966004419 homodimer interface [polypeptide binding]; other site 698966004420 catalytic residue [active] 698966004421 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 698966004422 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 698966004423 NAD binding site [chemical binding]; other site 698966004424 dimerization interface [polypeptide binding]; other site 698966004425 product binding site; other site 698966004426 substrate binding site [chemical binding]; other site 698966004427 zinc binding site [ion binding]; other site 698966004428 catalytic residues [active] 698966004429 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 698966004430 tetracycline repressor protein TetR; Provisional; Region: PRK13756 698966004431 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698966004432 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 698966004433 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 698966004434 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 698966004435 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 698966004436 active site 698966004437 catalytic site [active] 698966004438 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 698966004439 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 698966004440 active site 698966004441 catalytic site [active] 698966004442 substrate binding site [chemical binding]; other site 698966004443 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698966004444 synthetase active site [active] 698966004445 NTP binding site [chemical binding]; other site 698966004446 metal binding site [ion binding]; metal-binding site 698966004447 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698966004448 RNA binding surface [nucleotide binding]; other site 698966004449 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 698966004450 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 698966004451 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 698966004452 threonine dehydratase; Validated; Region: PRK08639 698966004453 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698966004454 tetramer interface [polypeptide binding]; other site 698966004455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698966004456 catalytic residue [active] 698966004457 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 698966004458 putative Ile/Val binding site [chemical binding]; other site 698966004459 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 698966004460 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 698966004461 active site 698966004462 PHP Thumb interface [polypeptide binding]; other site 698966004463 metal binding site [ion binding]; metal-binding site 698966004464 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698966004465 generic binding surface II; other site 698966004466 generic binding surface I; other site 698966004467 Predicted permeases [General function prediction only]; Region: RarD; COG2962 698966004468 EamA-like transporter family; Region: EamA; cl17759 698966004469 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 698966004470 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698966004471 RNA binding surface [nucleotide binding]; other site 698966004472 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698966004473 active site 698966004474 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 698966004475 lipoprotein signal peptidase; Provisional; Region: PRK14787 698966004476 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698966004477 active site 698966004478 homotetramer interface [polypeptide binding]; other site 698966004479 homodimer interface [polypeptide binding]; other site 698966004480 DNA polymerase IV; Provisional; Region: PRK03348 698966004481 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 698966004482 active site 698966004483 DNA binding site [nucleotide binding] 698966004484 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 698966004485 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698966004486 HIGH motif; other site 698966004487 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698966004488 active site 698966004489 KMSKS motif; other site 698966004490 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 698966004491 tRNA binding surface [nucleotide binding]; other site 698966004492 anticodon binding site; other site 698966004493 DivIVA domain; Region: DivI1A_domain; TIGR03544 698966004494 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698966004495 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 698966004496 Predicted integral membrane protein [Function unknown]; Region: COG0762 698966004497 Protein of unknown function (DUF552); Region: DUF552; cl00775 698966004498 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 698966004499 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 698966004500 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 698966004501 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 698966004502 nucleotide binding site [chemical binding]; other site 698966004503 SulA interaction site; other site 698966004504 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 698966004505 Cell division protein FtsQ; Region: FtsQ; pfam03799 698966004506 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 698966004507 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698966004508 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698966004509 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698966004510 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 698966004511 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 698966004512 active site 698966004513 homodimer interface [polypeptide binding]; other site 698966004514 cell division protein FtsW; Region: ftsW; TIGR02614 698966004515 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 698966004516 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698966004517 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698966004518 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 698966004519 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 698966004520 Mg++ binding site [ion binding]; other site 698966004521 putative catalytic motif [active] 698966004522 putative substrate binding site [chemical binding]; other site 698966004523 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 698966004524 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698966004525 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698966004526 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698966004527 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 698966004528 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698966004529 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698966004530 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698966004531 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698966004532 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698966004533 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698966004534 MraW methylase family; Region: Methyltransf_5; cl17771 698966004535 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 698966004536 cell division protein MraZ; Reviewed; Region: PRK00326 698966004537 MraZ protein; Region: MraZ; pfam02381 698966004538 MraZ protein; Region: MraZ; pfam02381 698966004539 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 698966004540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698966004541 Coenzyme A binding pocket [chemical binding]; other site 698966004542 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 698966004543 FAD binding site [chemical binding]; other site 698966004544 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698966004545 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698966004546 substrate binding pocket [chemical binding]; other site 698966004547 chain length determination region; other site 698966004548 substrate-Mg2+ binding site; other site 698966004549 catalytic residues [active] 698966004550 aspartate-rich region 1; other site 698966004551 active site lid residues [active] 698966004552 aspartate-rich region 2; other site 698966004553 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698966004554 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 698966004555 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698966004556 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698966004557 active site 698966004558 ATP binding site [chemical binding]; other site 698966004559 substrate binding site [chemical binding]; other site 698966004560 activation loop (A-loop); other site 698966004561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698966004562 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698966004563 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698966004564 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698966004565 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698966004566 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 698966004567 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698966004568 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698966004569 putative acyl-acceptor binding pocket; other site 698966004570 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698966004571 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698966004572 nucleotide binding site [chemical binding]; other site 698966004573 Tesmin/TSO1-like CXC domain; Region: CXC; pfam03638 698966004574 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698966004575 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698966004576 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698966004577 NlpC/P60 family; Region: NLPC_P60; pfam00877 698966004578 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698966004579 NlpC/P60 family; Region: NLPC_P60; pfam00877 698966004580 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 698966004581 heme bH binding site [chemical binding]; other site 698966004582 intrachain domain interface; other site 698966004583 heme bL binding site [chemical binding]; other site 698966004584 interchain domain interface [polypeptide binding]; other site 698966004585 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 698966004586 Qo binding site; other site 698966004587 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 698966004588 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698966004589 iron-sulfur cluster [ion binding]; other site 698966004590 [2Fe-2S] cluster binding site [ion binding]; other site 698966004591 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698966004592 Cytochrome c; Region: Cytochrom_C; pfam00034 698966004593 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698966004594 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 698966004595 Subunit I/III interface [polypeptide binding]; other site 698966004596 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 698966004597 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 698966004598 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 698966004599 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 698966004600 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 698966004601 active site 698966004602 dimer interface [polypeptide binding]; other site 698966004603 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 698966004604 Ligand Binding Site [chemical binding]; other site 698966004605 Molecular Tunnel; other site 698966004606 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 698966004607 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 698966004608 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 698966004609 homotrimer interface [polypeptide binding]; other site 698966004610 Walker A motif; other site 698966004611 GTP binding site [chemical binding]; other site 698966004612 Walker B motif; other site 698966004613 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 698966004614 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 698966004615 putative dimer interface [polypeptide binding]; other site 698966004616 active site pocket [active] 698966004617 putative cataytic base [active] 698966004618 cobalamin synthase; Reviewed; Region: cobS; PRK00235 698966004619 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 698966004620 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 698966004621 homodimer interface [polypeptide binding]; other site 698966004622 substrate-cofactor binding pocket; other site 698966004623 catalytic residue [active] 698966004624 multifunctional aminopeptidase A; Provisional; Region: PRK00913 698966004625 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 698966004626 interface (dimer of trimers) [polypeptide binding]; other site 698966004627 Substrate-binding/catalytic site; other site 698966004628 Zn-binding sites [ion binding]; other site 698966004629 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 698966004630 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698966004631 E3 interaction surface; other site 698966004632 lipoyl attachment site [posttranslational modification]; other site 698966004633 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698966004634 E3 interaction surface; other site 698966004635 lipoyl attachment site [posttranslational modification]; other site 698966004636 e3 binding domain; Region: E3_binding; pfam02817 698966004637 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698966004638 lipoate-protein ligase B; Provisional; Region: PRK14345 698966004639 lipoyl synthase; Provisional; Region: PRK05481 698966004640 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698966004641 FeS/SAM binding site; other site 698966004642 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 698966004643 RDD family; Region: RDD; pfam06271 698966004644 glutamine synthetase, type I; Region: GlnA; TIGR00653 698966004645 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698966004646 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698966004647 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 698966004648 MULE transposase domain; Region: MULE; pfam10551 698966004649 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698966004650 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 698966004651 Short repeats of unknown function; Region: ALF; pfam03752 698966004652 Short repeats of unknown function; Region: ALF; pfam03752 698966004653 Short repeats of unknown function; Region: ALF; pfam03752 698966004654 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 698966004655 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 698966004656 LGFP repeat; Region: LGFP; pfam08310 698966004657 LGFP repeat; Region: LGFP; pfam08310 698966004658 LGFP repeat; Region: LGFP; pfam08310 698966004659 AAA domain; Region: AAA_13; pfam13166 698966004660 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 698966004661 Predicted peptidase [General function prediction only]; Region: COG4099 698966004662 CsbD-like; Region: CsbD; pfam05532 698966004663 Predicted permease [General function prediction only]; Region: COG2056 698966004664 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 698966004665 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698966004666 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698966004667 DNA-binding site [nucleotide binding]; DNA binding site 698966004668 FCD domain; Region: FCD; pfam07729 698966004669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966004670 putative substrate translocation pore; other site 698966004671 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 698966004672 nudix motif; other site 698966004673 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 698966004674 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 698966004675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698966004676 catalytic residue [active] 698966004677 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 698966004678 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 698966004679 heme binding pocket [chemical binding]; other site 698966004680 heme ligand [chemical binding]; other site 698966004681 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 698966004682 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698966004683 metal binding triad; other site 698966004684 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698966004685 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698966004686 metal binding triad; other site 698966004687 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698966004688 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 698966004689 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698966004690 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698966004691 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 698966004692 putative active site; other site 698966004693 putative metal binding residues [ion binding]; other site 698966004694 signature motif; other site 698966004695 putative triphosphate binding site [ion binding]; other site 698966004696 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 698966004697 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 698966004698 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698966004699 RNB domain; Region: RNB; pfam00773 698966004700 Predicted membrane protein [General function prediction only]; Region: COG4194 698966004701 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 698966004702 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 698966004703 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 698966004704 RNA/DNA hybrid binding site [nucleotide binding]; other site 698966004705 active site 698966004706 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698966004707 catalytic core [active] 698966004708 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 698966004709 Putative zinc ribbon domain; Region: DUF164; pfam02591 698966004710 Uncharacterized conserved protein [Function unknown]; Region: COG0327 698966004711 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698966004712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 698966004713 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698966004714 hypothetical protein; Provisional; Region: PRK07908 698966004715 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698966004716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698966004717 homodimer interface [polypeptide binding]; other site 698966004718 catalytic residue [active] 698966004719 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 698966004720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698966004721 motif II; other site 698966004722 Low molecular weight phosphatase family; Region: LMWPc; cd00115 698966004723 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 698966004724 active site 698966004725 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 698966004726 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 698966004727 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 698966004728 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 698966004729 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 698966004730 dimer interface [polypeptide binding]; other site 698966004731 TPP-binding site [chemical binding]; other site 698966004732 Electron transfer DM13; Region: DM13; pfam10517 698966004733 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698966004734 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698966004735 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698966004736 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 698966004737 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698966004738 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698966004739 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698966004740 active site 698966004741 motif I; other site 698966004742 motif II; other site 698966004743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698966004744 motif II; other site 698966004745 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698966004746 Beta-lactamase; Region: Beta-lactamase; pfam00144 698966004747 Predicted membrane protein [Function unknown]; Region: COG2860 698966004748 UPF0126 domain; Region: UPF0126; pfam03458 698966004749 UPF0126 domain; Region: UPF0126; pfam03458 698966004750 DNA primase; Validated; Region: dnaG; PRK05667 698966004751 CHC2 zinc finger; Region: zf-CHC2; pfam01807 698966004752 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 698966004753 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 698966004754 active site 698966004755 metal binding site [ion binding]; metal-binding site 698966004756 interdomain interaction site; other site 698966004757 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 698966004758 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 698966004759 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 698966004760 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 698966004761 glutaminase active site [active] 698966004762 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698966004763 dimer interface [polypeptide binding]; other site 698966004764 active site 698966004765 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 698966004766 dimer interface [polypeptide binding]; other site 698966004767 active site 698966004768 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 698966004769 active site 698966004770 barstar interaction site; other site 698966004771 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 698966004772 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698966004773 Zn2+ binding site [ion binding]; other site 698966004774 Mg2+ binding site [ion binding]; other site 698966004775 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 698966004776 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698966004777 putative active site [active] 698966004778 Repair protein; Region: Repair_PSII; pfam04536 698966004779 glycyl-tRNA synthetase; Provisional; Region: PRK04173 698966004780 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698966004781 motif 1; other site 698966004782 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 698966004783 active site 698966004784 motif 2; other site 698966004785 motif 3; other site 698966004786 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 698966004787 anticodon binding site; other site 698966004788 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698966004789 putative DNA binding site [nucleotide binding]; other site 698966004790 putative Zn2+ binding site [ion binding]; other site 698966004791 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698966004792 metal binding site 2 [ion binding]; metal-binding site 698966004793 putative DNA binding helix; other site 698966004794 metal binding site 1 [ion binding]; metal-binding site 698966004795 dimer interface [polypeptide binding]; other site 698966004796 structural Zn2+ binding site [ion binding]; other site 698966004797 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 698966004798 diiron binding motif [ion binding]; other site 698966004799 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 698966004800 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698966004801 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 698966004802 catalytic residue [active] 698966004803 putative FPP diphosphate binding site; other site 698966004804 putative FPP binding hydrophobic cleft; other site 698966004805 dimer interface [polypeptide binding]; other site 698966004806 putative IPP diphosphate binding site; other site 698966004807 Recombination protein O N terminal; Region: RecO_N; pfam11967 698966004808 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 698966004809 Recombination protein O C terminal; Region: RecO_C; pfam02565 698966004810 GTPase Era; Reviewed; Region: era; PRK00089 698966004811 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 698966004812 G1 box; other site 698966004813 GTP/Mg2+ binding site [chemical binding]; other site 698966004814 Switch I region; other site 698966004815 G2 box; other site 698966004816 Switch II region; other site 698966004817 G3 box; other site 698966004818 G4 box; other site 698966004819 G5 box; other site 698966004820 KH domain; Region: KH_2; pfam07650 698966004821 pyridoxamine kinase; Validated; Region: PRK05756 698966004822 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 698966004823 dimer interface [polypeptide binding]; other site 698966004824 pyridoxal binding site [chemical binding]; other site 698966004825 ATP binding site [chemical binding]; other site 698966004826 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698966004827 Domain of unknown function DUF21; Region: DUF21; pfam01595 698966004828 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698966004829 Transporter associated domain; Region: CorC_HlyC; smart01091 698966004830 metal-binding heat shock protein; Provisional; Region: PRK00016 698966004831 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 698966004832 PhoH-like protein; Region: PhoH; pfam02562 698966004833 RNA methyltransferase, RsmE family; Region: TIGR00046 698966004834 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 698966004835 chaperone protein DnaJ; Provisional; Region: PRK14278 698966004836 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698966004837 HSP70 interaction site [polypeptide binding]; other site 698966004838 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698966004839 Zn binding sites [ion binding]; other site 698966004840 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698966004841 dimer interface [polypeptide binding]; other site 698966004842 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 698966004843 coproporphyrinogen III oxidase; Validated; Region: PRK05628 698966004844 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698966004845 FeS/SAM binding site; other site 698966004846 HemN C-terminal domain; Region: HemN_C; pfam06969 698966004847 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698966004848 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698966004849 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698966004850 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698966004851 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 698966004852 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 698966004853 acyl-activating enzyme (AAE) consensus motif; other site 698966004854 putative AMP binding site [chemical binding]; other site 698966004855 putative active site [active] 698966004856 putative CoA binding site [chemical binding]; other site 698966004857 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 698966004858 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 698966004859 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 698966004860 active site 698966004861 Zn binding site [ion binding]; other site 698966004862 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698966004863 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698966004864 substrate binding pocket [chemical binding]; other site 698966004865 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 698966004866 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 698966004867 active site 698966004868 metal binding site [ion binding]; metal-binding site 698966004869 nudix motif; other site 698966004870 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698966004871 active site 698966004872 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698966004873 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698966004874 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966004875 Walker A/P-loop; other site 698966004876 ATP binding site [chemical binding]; other site 698966004877 Q-loop/lid; other site 698966004878 ABC transporter signature motif; other site 698966004879 Walker B; other site 698966004880 D-loop; other site 698966004881 H-loop/switch region; other site 698966004882 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 698966004883 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698966004884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698966004885 homodimer interface [polypeptide binding]; other site 698966004886 catalytic residue [active] 698966004887 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 698966004888 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698966004889 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 698966004890 BCCT family transporter; Region: BCCT; pfam02028 698966004891 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698966004892 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 698966004893 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698966004894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698966004895 dimer interface [polypeptide binding]; other site 698966004896 conserved gate region; other site 698966004897 putative PBP binding loops; other site 698966004898 ABC-ATPase subunit interface; other site 698966004899 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698966004900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698966004901 dimer interface [polypeptide binding]; other site 698966004902 conserved gate region; other site 698966004903 putative PBP binding loops; other site 698966004904 ABC-ATPase subunit interface; other site 698966004905 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698966004906 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698966004907 Walker A/P-loop; other site 698966004908 ATP binding site [chemical binding]; other site 698966004909 Q-loop/lid; other site 698966004910 ABC transporter signature motif; other site 698966004911 Walker B; other site 698966004912 D-loop; other site 698966004913 H-loop/switch region; other site 698966004914 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698966004915 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698966004916 Walker A/P-loop; other site 698966004917 ATP binding site [chemical binding]; other site 698966004918 Q-loop/lid; other site 698966004919 ABC transporter signature motif; other site 698966004920 Walker B; other site 698966004921 D-loop; other site 698966004922 H-loop/switch region; other site 698966004923 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698966004924 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 698966004925 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 698966004926 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698966004927 catalytic residue [active] 698966004928 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698966004929 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698966004930 nucleotide binding site [chemical binding]; other site 698966004931 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 698966004932 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698966004933 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698966004934 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 698966004935 active site residue [active] 698966004936 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 698966004937 putative homodimer interface [polypeptide binding]; other site 698966004938 putative homotetramer interface [polypeptide binding]; other site 698966004939 putative allosteric switch controlling residues; other site 698966004940 putative metal binding site [ion binding]; other site 698966004941 putative homodimer-homodimer interface [polypeptide binding]; other site 698966004942 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 698966004943 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698966004944 TrkA-N domain; Region: TrkA_N; pfam02254 698966004945 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 698966004946 potential frameshift: common BLAST hit: gi|38234323|ref|NP_940090.1| antibiotic ABC transporter 698966004947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966004948 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698966004949 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 698966004950 active site 698966004951 tetramer interface [polypeptide binding]; other site 698966004952 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698966004953 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 698966004954 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698966004955 Mrr N-terminal domain; Region: Mrr_N; pfam14338 698966004956 Restriction endonuclease; Region: Mrr_cat; pfam04471 698966004957 Abi-like protein; Region: Abi_2; pfam07751 698966004958 GTP-binding protein LepA; Provisional; Region: PRK05433 698966004959 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 698966004960 G1 box; other site 698966004961 putative GEF interaction site [polypeptide binding]; other site 698966004962 GTP/Mg2+ binding site [chemical binding]; other site 698966004963 Switch I region; other site 698966004964 G2 box; other site 698966004965 G3 box; other site 698966004966 Switch II region; other site 698966004967 G4 box; other site 698966004968 G5 box; other site 698966004969 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 698966004970 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 698966004971 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 698966004972 PemK-like protein; Region: PemK; pfam02452 698966004973 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 698966004974 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698966004975 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 698966004976 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 698966004977 hypothetical protein; Validated; Region: PRK05629 698966004978 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 698966004979 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 698966004980 Competence protein; Region: Competence; pfam03772 698966004981 comEA protein; Region: comE; TIGR01259 698966004982 Helix-hairpin-helix motif; Region: HHH; pfam00633 698966004983 helix-hairpin-helix signature motif; other site 698966004984 EDD domain protein, DegV family; Region: DegV; TIGR00762 698966004985 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 698966004986 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698966004987 catalytic core [active] 698966004988 Oligomerisation domain; Region: Oligomerisation; cl00519 698966004989 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 698966004990 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 698966004991 active site 698966004992 (T/H)XGH motif; other site 698966004993 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 698966004994 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 698966004995 putative catalytic cysteine [active] 698966004996 gamma-glutamyl kinase; Provisional; Region: PRK05429 698966004997 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 698966004998 nucleotide binding site [chemical binding]; other site 698966004999 homotetrameric interface [polypeptide binding]; other site 698966005000 putative phosphate binding site [ion binding]; other site 698966005001 putative allosteric binding site; other site 698966005002 PUA domain; Region: PUA; pfam01472 698966005003 GTPase CgtA; Reviewed; Region: obgE; PRK12296 698966005004 GTP1/OBG; Region: GTP1_OBG; pfam01018 698966005005 Obg GTPase; Region: Obg; cd01898 698966005006 G1 box; other site 698966005007 GTP/Mg2+ binding site [chemical binding]; other site 698966005008 Switch I region; other site 698966005009 G2 box; other site 698966005010 G3 box; other site 698966005011 Switch II region; other site 698966005012 G4 box; other site 698966005013 G5 box; other site 698966005014 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 698966005015 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 698966005016 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 698966005017 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 698966005018 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698966005019 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 698966005020 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 698966005021 homodimer interface [polypeptide binding]; other site 698966005022 oligonucleotide binding site [chemical binding]; other site 698966005023 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 698966005024 active site 698966005025 multimer interface [polypeptide binding]; other site 698966005026 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 698966005027 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 698966005028 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698966005029 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698966005030 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 698966005031 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698966005032 active site 698966005033 HIGH motif; other site 698966005034 nucleotide binding site [chemical binding]; other site 698966005035 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698966005036 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 698966005037 active site 698966005038 KMSKS motif; other site 698966005039 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 698966005040 tRNA binding surface [nucleotide binding]; other site 698966005041 anticodon binding site; other site 698966005042 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 698966005043 malate dehydrogenase; Provisional; Region: PRK05442 698966005044 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 698966005045 NAD(P) binding site [chemical binding]; other site 698966005046 dimer interface [polypeptide binding]; other site 698966005047 malate binding site [chemical binding]; other site 698966005048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698966005049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698966005050 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 698966005051 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 698966005052 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 698966005053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698966005054 Walker A motif; other site 698966005055 ATP binding site [chemical binding]; other site 698966005056 Walker B motif; other site 698966005057 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 698966005058 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698966005059 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698966005060 glutamine binding [chemical binding]; other site 698966005061 catalytic triad [active] 698966005062 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 698966005063 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698966005064 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 698966005065 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 698966005066 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698966005067 oligomer interface [polypeptide binding]; other site 698966005068 active site residues [active] 698966005069 Clp protease; Region: CLP_protease; pfam00574 698966005070 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698966005071 oligomer interface [polypeptide binding]; other site 698966005072 active site residues [active] 698966005073 trigger factor; Provisional; Region: tig; PRK01490 698966005074 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698966005075 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 698966005076 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 698966005077 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698966005078 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698966005079 catalytic residues [active] 698966005080 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 698966005081 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 698966005082 Zn binding site [ion binding]; other site 698966005083 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698966005084 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698966005085 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 698966005086 apolar tunnel; other site 698966005087 heme binding site [chemical binding]; other site 698966005088 dimerization interface [polypeptide binding]; other site 698966005089 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698966005090 active site 698966005091 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 698966005092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966005093 Walker A/P-loop; other site 698966005094 ATP binding site [chemical binding]; other site 698966005095 Q-loop/lid; other site 698966005096 ABC transporter signature motif; other site 698966005097 Walker B; other site 698966005098 D-loop; other site 698966005099 H-loop/switch region; other site 698966005100 ABC transporter; Region: ABC_tran_2; pfam12848 698966005101 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698966005102 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698966005103 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698966005104 dimer interface [polypeptide binding]; other site 698966005105 ssDNA binding site [nucleotide binding]; other site 698966005106 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698966005107 Copper resistance protein D; Region: CopD; pfam05425 698966005108 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 698966005109 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 698966005110 Carbon starvation protein CstA; Region: CstA; pfam02554 698966005111 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 698966005112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966005113 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698966005114 putative substrate translocation pore; other site 698966005115 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 698966005116 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 698966005117 NADP binding site [chemical binding]; other site 698966005118 dimer interface [polypeptide binding]; other site 698966005119 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698966005120 classical (c) SDRs; Region: SDR_c; cd05233 698966005121 NAD(P) binding site [chemical binding]; other site 698966005122 active site 698966005123 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 698966005124 catalytic site [active] 698966005125 putative active site [active] 698966005126 putative substrate binding site [chemical binding]; other site 698966005127 dimer interface [polypeptide binding]; other site 698966005128 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698966005129 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698966005130 inhibitor site; inhibition site 698966005131 active site 698966005132 dimer interface [polypeptide binding]; other site 698966005133 catalytic residue [active] 698966005134 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 698966005135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698966005136 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 698966005137 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698966005138 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 698966005139 conserved cis-peptide bond; other site 698966005140 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 698966005141 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 698966005142 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698966005143 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 698966005144 catalytic triad [active] 698966005145 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698966005146 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698966005147 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 698966005148 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698966005149 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 698966005150 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698966005151 phosphate binding site [ion binding]; other site 698966005152 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 698966005153 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 698966005154 active site 2 [active] 698966005155 active site 1 [active] 698966005156 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 698966005157 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698966005158 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 698966005159 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 698966005160 putative NAD(P) binding site [chemical binding]; other site 698966005161 active site 698966005162 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 698966005163 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 698966005164 active site 698966005165 Glucitol operon activator protein (GutM); Region: GutM; cl01890 698966005166 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 698966005167 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 698966005168 active site 698966005169 dimerization interface [polypeptide binding]; other site 698966005170 ribonuclease PH; Reviewed; Region: rph; PRK00173 698966005171 Ribonuclease PH; Region: RNase_PH_bact; cd11362 698966005172 hexamer interface [polypeptide binding]; other site 698966005173 active site 698966005174 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 698966005175 glutamate racemase; Provisional; Region: PRK00865 698966005176 Rhomboid family; Region: Rhomboid; pfam01694 698966005177 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 698966005178 putative active site pocket [active] 698966005179 cleavage site 698966005180 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 698966005181 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 698966005182 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 698966005183 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 698966005184 active site 698966005185 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 698966005186 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698966005187 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698966005188 putative Mg++ binding site [ion binding]; other site 698966005189 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 698966005190 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698966005191 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698966005192 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698966005193 active site 698966005194 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 698966005195 dimer interface [polypeptide binding]; other site 698966005196 putative active site [active] 698966005197 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 698966005198 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 698966005199 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 698966005200 phosphoserine phosphatase SerB; Region: serB; TIGR00338 698966005201 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698966005202 motif II; other site 698966005203 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 698966005204 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 698966005205 D-pathway; other site 698966005206 Putative ubiquinol binding site [chemical binding]; other site 698966005207 Low-spin heme (heme b) binding site [chemical binding]; other site 698966005208 Putative water exit pathway; other site 698966005209 Binuclear center (heme o3/CuB) [ion binding]; other site 698966005210 K-pathway; other site 698966005211 Putative proton exit pathway; other site 698966005212 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698966005213 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698966005214 dimer interface [polypeptide binding]; other site 698966005215 putative radical transfer pathway; other site 698966005216 diiron center [ion binding]; other site 698966005217 tyrosyl radical; other site 698966005218 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 698966005219 Ferritin-like domain; Region: Ferritin; pfam00210 698966005220 ferroxidase diiron center [ion binding]; other site 698966005221 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 698966005222 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 698966005223 Class I ribonucleotide reductase; Region: RNR_I; cd01679 698966005224 active site 698966005225 dimer interface [polypeptide binding]; other site 698966005226 catalytic residues [active] 698966005227 effector binding site; other site 698966005228 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698966005229 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698966005230 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698966005231 catalytic residues [active] 698966005232 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 698966005233 active site lid residues [active] 698966005234 substrate binding pocket [chemical binding]; other site 698966005235 catalytic residues [active] 698966005236 substrate-Mg2+ binding site; other site 698966005237 aspartate-rich region 1; other site 698966005238 aspartate-rich region 2; other site 698966005239 phytoene desaturase; Region: crtI_fam; TIGR02734 698966005240 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698966005241 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 698966005242 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 698966005243 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 698966005244 homodimer interface [polypeptide binding]; other site 698966005245 NAD binding pocket [chemical binding]; other site 698966005246 ATP binding pocket [chemical binding]; other site 698966005247 Mg binding site [ion binding]; other site 698966005248 active-site loop [active] 698966005249 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 698966005250 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 698966005251 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 698966005252 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 698966005253 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 698966005254 Predicted transcriptional regulator [Transcription]; Region: COG2345 698966005255 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 698966005256 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698966005257 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 698966005258 catalytic residues [active] 698966005259 Methylamine utilisation protein MauE; Region: MauE; pfam07291 698966005260 phosphoglucomutase; Validated; Region: PRK07564 698966005261 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 698966005262 active site 698966005263 substrate binding site [chemical binding]; other site 698966005264 metal binding site [ion binding]; metal-binding site 698966005265 CrcB-like protein; Region: CRCB; pfam02537 698966005266 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698966005267 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698966005268 FtsX-like permease family; Region: FtsX; pfam02687 698966005269 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698966005270 FtsX-like permease family; Region: FtsX; pfam02687 698966005271 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698966005272 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698966005273 Walker A/P-loop; other site 698966005274 ATP binding site [chemical binding]; other site 698966005275 Q-loop/lid; other site 698966005276 ABC transporter signature motif; other site 698966005277 Walker B; other site 698966005278 D-loop; other site 698966005279 H-loop/switch region; other site 698966005280 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698966005281 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698966005282 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698966005283 hinge; other site 698966005284 active site 698966005285 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 698966005286 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 698966005287 GAF domain; Region: GAF_2; pfam13185 698966005288 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698966005289 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698966005290 DNA binding residues [nucleotide binding] 698966005291 dimerization interface [polypeptide binding]; other site 698966005292 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698966005293 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698966005294 dimer interface [polypeptide binding]; other site 698966005295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698966005296 catalytic residue [active] 698966005297 serine O-acetyltransferase; Region: cysE; TIGR01172 698966005298 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 698966005299 trimer interface [polypeptide binding]; other site 698966005300 active site 698966005301 substrate binding site [chemical binding]; other site 698966005302 CoA binding site [chemical binding]; other site 698966005303 Predicted acetyltransferase [General function prediction only]; Region: COG2388 698966005304 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 698966005305 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 698966005306 putative active site [active] 698966005307 metal binding site [ion binding]; metal-binding site 698966005308 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 698966005309 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698966005310 Walker A/P-loop; other site 698966005311 ATP binding site [chemical binding]; other site 698966005312 Q-loop/lid; other site 698966005313 ABC transporter signature motif; other site 698966005314 Walker B; other site 698966005315 D-loop; other site 698966005316 H-loop/switch region; other site 698966005317 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 698966005318 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698966005319 intersubunit interface [polypeptide binding]; other site 698966005320 ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism]; Region: FepD; COG0609 698966005321 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698966005322 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698966005323 ABC-ATPase subunit interface; other site 698966005324 dimer interface [polypeptide binding]; other site 698966005325 putative PBP binding regions; other site 698966005326 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698966005327 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 698966005328 DNA methylase; Region: N6_N4_Mtase; pfam01555 698966005329 DNA methylase; Region: N6_N4_Mtase; pfam01555 698966005330 HTH-like domain; Region: HTH_21; pfam13276 698966005331 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 698966005332 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 698966005333 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698966005334 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698966005335 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 698966005336 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966005337 Walker A/P-loop; other site 698966005338 ATP binding site [chemical binding]; other site 698966005339 Q-loop/lid; other site 698966005340 ABC transporter signature motif; other site 698966005341 Walker B; other site 698966005342 D-loop; other site 698966005343 H-loop/switch region; other site 698966005344 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 698966005345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966005346 Walker A/P-loop; other site 698966005347 ATP binding site [chemical binding]; other site 698966005348 Q-loop/lid; other site 698966005349 ABC transporter signature motif; other site 698966005350 Walker B; other site 698966005351 D-loop; other site 698966005352 H-loop/switch region; other site 698966005353 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 698966005354 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 698966005355 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 698966005356 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 698966005357 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 698966005358 FMN binding site [chemical binding]; other site 698966005359 active site 698966005360 catalytic residues [active] 698966005361 substrate binding site [chemical binding]; other site 698966005362 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 698966005363 PhoU domain; Region: PhoU; pfam01895 698966005364 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 698966005365 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 698966005366 Walker A/P-loop; other site 698966005367 ATP binding site [chemical binding]; other site 698966005368 Q-loop/lid; other site 698966005369 ABC transporter signature motif; other site 698966005370 Walker B; other site 698966005371 D-loop; other site 698966005372 H-loop/switch region; other site 698966005373 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 698966005374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698966005375 dimer interface [polypeptide binding]; other site 698966005376 conserved gate region; other site 698966005377 putative PBP binding loops; other site 698966005378 ABC-ATPase subunit interface; other site 698966005379 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 698966005380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698966005381 dimer interface [polypeptide binding]; other site 698966005382 conserved gate region; other site 698966005383 putative PBP binding loops; other site 698966005384 ABC-ATPase subunit interface; other site 698966005385 PBP superfamily domain; Region: PBP_like_2; cl17296 698966005386 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 698966005387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698966005388 Coenzyme A binding pocket [chemical binding]; other site 698966005389 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698966005390 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698966005391 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 698966005392 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 698966005393 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 698966005394 heme-binding site [chemical binding]; other site 698966005395 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 698966005396 substrate binding site [chemical binding]; other site 698966005397 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 698966005398 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 698966005399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698966005400 catalytic residue [active] 698966005401 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 698966005402 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 698966005403 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698966005404 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 698966005405 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 698966005406 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 698966005407 dimerization interface [polypeptide binding]; other site 698966005408 putative ATP binding site [chemical binding]; other site 698966005409 amidophosphoribosyltransferase; Provisional; Region: PRK07847 698966005410 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 698966005411 active site 698966005412 tetramer interface [polypeptide binding]; other site 698966005413 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698966005414 active site 698966005415 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 698966005416 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 698966005417 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698966005418 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698966005419 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698966005420 dimer interface [polypeptide binding]; other site 698966005421 putative radical transfer pathway; other site 698966005422 diiron center [ion binding]; other site 698966005423 tyrosyl radical; other site 698966005424 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 698966005425 catalytic residues [active] 698966005426 dimer interface [polypeptide binding]; other site 698966005427 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 698966005428 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698966005429 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 698966005430 ATP binding site [chemical binding]; other site 698966005431 active site 698966005432 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 698966005433 substrate binding site [chemical binding]; other site 698966005434 adenylosuccinate lyase; Region: purB; TIGR00928 698966005435 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 698966005436 tetramer interface [polypeptide binding]; other site 698966005437 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 698966005438 TrkA-N domain; Region: TrkA_N; pfam02254 698966005439 TrkA-C domain; Region: TrkA_C; pfam02080 698966005440 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 698966005441 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 698966005442 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 698966005443 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 698966005444 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 698966005445 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 698966005446 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 698966005447 nucleotide binding site/active site [active] 698966005448 HIT family signature motif; other site 698966005449 catalytic residue [active] 698966005450 PGAP1-like protein; Region: PGAP1; pfam07819 698966005451 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698966005452 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698966005453 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698966005454 dimerization interface [polypeptide binding]; other site 698966005455 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698966005456 dimer interface [polypeptide binding]; other site 698966005457 phosphorylation site [posttranslational modification] 698966005458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698966005459 ATP binding site [chemical binding]; other site 698966005460 Mg2+ binding site [ion binding]; other site 698966005461 G-X-G motif; other site 698966005462 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698966005463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698966005464 active site 698966005465 phosphorylation site [posttranslational modification] 698966005466 intermolecular recognition site; other site 698966005467 dimerization interface [polypeptide binding]; other site 698966005468 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698966005469 DNA binding site [nucleotide binding] 698966005470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966005471 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698966005472 putative substrate translocation pore; other site 698966005473 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698966005474 xanthine permease; Region: pbuX; TIGR03173 698966005475 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 698966005476 pyruvate dehydrogenase; Provisional; Region: PRK06546 698966005477 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 698966005478 PYR/PP interface [polypeptide binding]; other site 698966005479 dimer interface [polypeptide binding]; other site 698966005480 tetramer interface [polypeptide binding]; other site 698966005481 TPP binding site [chemical binding]; other site 698966005482 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698966005483 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 698966005484 TPP-binding site [chemical binding]; other site 698966005485 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698966005486 Uncharacterized conserved protein [Function unknown]; Region: COG3610 698966005487 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698966005488 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698966005489 Uncharacterized conserved protein [Function unknown]; Region: COG3610 698966005490 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 698966005491 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 698966005492 active site 698966005493 homotetramer interface [polypeptide binding]; other site 698966005494 META domain; Region: META; cl01245 698966005495 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 698966005496 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 698966005497 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698966005498 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698966005499 DNA binding site [nucleotide binding] 698966005500 domain linker motif; other site 698966005501 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 698966005502 putative dimerization interface [polypeptide binding]; other site 698966005503 putative ligand binding site [chemical binding]; other site 698966005504 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698966005505 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 698966005506 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698966005507 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 698966005508 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698966005509 active site 698966005510 HIGH motif; other site 698966005511 nucleotide binding site [chemical binding]; other site 698966005512 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698966005513 KMSKS motif; other site 698966005514 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698966005515 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 698966005516 homotrimer interaction site [polypeptide binding]; other site 698966005517 zinc binding site [ion binding]; other site 698966005518 CDP-binding sites; other site 698966005519 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 698966005520 substrate binding site; other site 698966005521 dimer interface; other site 698966005522 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 698966005523 DNA repair protein RadA; Provisional; Region: PRK11823 698966005524 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698966005525 Walker A motif; other site 698966005526 ATP binding site [chemical binding]; other site 698966005527 Walker B motif; other site 698966005528 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698966005529 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 698966005530 active site clefts [active] 698966005531 zinc binding site [ion binding]; other site 698966005532 dimer interface [polypeptide binding]; other site 698966005533 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698966005534 endonuclease III; Region: ENDO3c; smart00478 698966005535 minor groove reading motif; other site 698966005536 helix-hairpin-helix signature motif; other site 698966005537 substrate binding pocket [chemical binding]; other site 698966005538 active site 698966005539 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698966005540 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698966005541 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 698966005542 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 698966005543 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 698966005544 Clp amino terminal domain; Region: Clp_N; pfam02861 698966005545 Clp amino terminal domain; Region: Clp_N; pfam02861 698966005546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698966005547 Walker A motif; other site 698966005548 ATP binding site [chemical binding]; other site 698966005549 Walker B motif; other site 698966005550 arginine finger; other site 698966005551 UvrB/uvrC motif; Region: UVR; pfam02151 698966005552 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698966005553 Walker A motif; other site 698966005554 ATP binding site [chemical binding]; other site 698966005555 Walker B motif; other site 698966005556 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698966005557 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 698966005558 oligomer interface [polypeptide binding]; other site 698966005559 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698966005560 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698966005561 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 698966005562 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698966005563 dimer interface [polypeptide binding]; other site 698966005564 putative anticodon binding site; other site 698966005565 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698966005566 motif 1; other site 698966005567 dimer interface [polypeptide binding]; other site 698966005568 active site 698966005569 motif 2; other site 698966005570 motif 3; other site 698966005571 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698966005572 YcaO-like family; Region: YcaO; pfam02624 698966005573 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698966005574 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698966005575 Walker A/P-loop; other site 698966005576 ATP binding site [chemical binding]; other site 698966005577 Q-loop/lid; other site 698966005578 ABC transporter signature motif; other site 698966005579 Walker B; other site 698966005580 D-loop; other site 698966005581 H-loop/switch region; other site 698966005582 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698966005583 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 698966005584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 698966005585 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698966005586 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698966005587 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698966005588 active site 698966005589 KMSKS motif; other site 698966005590 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 698966005591 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 698966005592 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 698966005593 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 698966005594 catalytic center binding site [active] 698966005595 ATP binding site [chemical binding]; other site 698966005596 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 698966005597 homooctamer interface [polypeptide binding]; other site 698966005598 active site 698966005599 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698966005600 dihydropteroate synthase; Region: DHPS; TIGR01496 698966005601 substrate binding pocket [chemical binding]; other site 698966005602 dimer interface [polypeptide binding]; other site 698966005603 inhibitor binding site; inhibition site 698966005604 Protein of unknown function, DUF393; Region: DUF393; pfam04134 698966005605 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 698966005606 homodecamer interface [polypeptide binding]; other site 698966005607 GTP cyclohydrolase I; Provisional; Region: PLN03044 698966005608 active site 698966005609 putative catalytic site residues [active] 698966005610 zinc binding site [ion binding]; other site 698966005611 GTP-CH-I/GFRP interaction surface; other site 698966005612 FtsH Extracellular; Region: FtsH_ext; pfam06480 698966005613 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 698966005614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698966005615 Walker A motif; other site 698966005616 ATP binding site [chemical binding]; other site 698966005617 Walker B motif; other site 698966005618 arginine finger; other site 698966005619 Peptidase family M41; Region: Peptidase_M41; pfam01434 698966005620 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698966005621 active site 698966005622 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 698966005623 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 698966005624 Ligand Binding Site [chemical binding]; other site 698966005625 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 698966005626 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 698966005627 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 698966005628 dimer interface [polypeptide binding]; other site 698966005629 substrate binding site [chemical binding]; other site 698966005630 metal binding sites [ion binding]; metal-binding site 698966005631 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698966005632 active site residue [active] 698966005633 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698966005634 MarR family; Region: MarR_2; pfam12802 698966005635 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698966005636 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 698966005637 acyl-activating enzyme (AAE) consensus motif; other site 698966005638 AMP binding site [chemical binding]; other site 698966005639 active site 698966005640 CoA binding site [chemical binding]; other site 698966005641 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698966005642 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 698966005643 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698966005644 putative trimer interface [polypeptide binding]; other site 698966005645 putative CoA binding site [chemical binding]; other site 698966005646 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698966005647 putative trimer interface [polypeptide binding]; other site 698966005648 putative CoA binding site [chemical binding]; other site 698966005649 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698966005650 metal ion-dependent adhesion site (MIDAS); other site 698966005651 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698966005652 active site 698966005653 catalytic site [active] 698966005654 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698966005655 Secretory lipase; Region: LIP; pfam03583 698966005656 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698966005657 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 698966005658 CENP-B N-terminal DNA-binding domain; Region: CENP-B_N; pfam04218 698966005659 putative transposase OrfB; Reviewed; Region: PHA02517 698966005660 HTH-like domain; Region: HTH_21; pfam13276 698966005661 Integrase core domain; Region: rve; pfam00665 698966005662 Integrase core domain; Region: rve_2; pfam13333 698966005663 putative transposase OrfB; Reviewed; Region: PHA02517 698966005664 HTH-like domain; Region: HTH_21; pfam13276 698966005665 Integrase core domain; Region: rve; pfam00665 698966005666 Integrase core domain; Region: rve_2; pfam13333 698966005667 Homeodomain-like domain; Region: HTH_23; cl17451 698966005668 Helix-turn-helix domain; Region: HTH_28; pfam13518 698966005669 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698966005670 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698966005671 ring oligomerisation interface [polypeptide binding]; other site 698966005672 ATP/Mg binding site [chemical binding]; other site 698966005673 stacking interactions; other site 698966005674 hinge regions; other site 698966005675 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698966005676 MULE transposase domain; Region: MULE; pfam10551 698966005677 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698966005678 potential frameshift: common BLAST hit: gi|38233440|ref|NP_939207.1| transposase 698966005679 Integrase core domain; Region: rve; pfam00665 698966005680 Integrase core domain; Region: rve_2; pfam13333 698966005681 MULE transposase domain; Region: MULE; pfam10551 698966005682 hypothetical protein; Provisional; Region: PRK07907 698966005683 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 698966005684 active site 698966005685 metal binding site [ion binding]; metal-binding site 698966005686 dimer interface [polypeptide binding]; other site 698966005687 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698966005688 carboxylate-amine ligase; Provisional; Region: PRK13517 698966005689 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 698966005690 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698966005691 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698966005692 active site 698966005693 catalytic residues [active] 698966005694 metal binding site [ion binding]; metal-binding site 698966005695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698966005696 Coenzyme A binding pocket [chemical binding]; other site 698966005697 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698966005698 putative catalytic site [active] 698966005699 putative metal binding site [ion binding]; other site 698966005700 putative phosphate binding site [ion binding]; other site 698966005701 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 698966005702 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 698966005703 putative active site [active] 698966005704 catalytic site [active] 698966005705 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 698966005706 putative active site [active] 698966005707 catalytic site [active] 698966005708 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698966005709 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698966005710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966005711 Walker A/P-loop; other site 698966005712 ATP binding site [chemical binding]; other site 698966005713 Q-loop/lid; other site 698966005714 ABC transporter signature motif; other site 698966005715 Walker B; other site 698966005716 D-loop; other site 698966005717 H-loop/switch region; other site 698966005718 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 698966005719 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698966005720 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698966005721 substrate binding pocket [chemical binding]; other site 698966005722 membrane-bound complex binding site; other site 698966005723 hinge residues; other site 698966005724 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698966005725 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698966005726 active site 698966005727 ATP binding site [chemical binding]; other site 698966005728 substrate binding site [chemical binding]; other site 698966005729 activation loop (A-loop); other site 698966005730 propionate/acetate kinase; Provisional; Region: PRK12379 698966005731 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 698966005732 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 698966005733 ferredoxin-NADP+ reductase; Region: PLN02852 698966005734 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698966005735 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698966005736 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 698966005737 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698966005738 active site 698966005739 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698966005740 putative active site [active] 698966005741 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 698966005742 Cna protein B-type domain; Region: Cna_B; pfam05738 698966005743 Cna protein B-type domain; Region: Cna_B; pfam05738 698966005744 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 698966005745 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 698966005746 GDP-binding site [chemical binding]; other site 698966005747 ACT binding site; other site 698966005748 IMP binding site; other site 698966005749 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698966005750 conserved repeat domain; Region: B_ant_repeat; TIGR01451 698966005751 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 698966005752 Predicted membrane protein [Function unknown]; Region: COG4129 698966005753 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698966005754 chromosome segregation protein; Provisional; Region: PRK03918 698966005755 Predicted membrane protein [Function unknown]; Region: COG4129 698966005756 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698966005757 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 698966005758 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698966005759 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 698966005760 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698966005761 Transposase; Region: HTH_Tnp_1; pfam01527 698966005762 HTH-like domain; Region: HTH_21; pfam13276 698966005763 Integrase core domain; Region: rve; pfam00665 698966005764 putative transporter; Provisional; Region: PRK09821 698966005765 GntP family permease; Region: GntP_permease; pfam02447 698966005766 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698966005767 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698966005768 NAD(P) binding site [chemical binding]; other site 698966005769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 698966005770 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698966005771 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698966005772 DNA-binding site [nucleotide binding]; DNA binding site 698966005773 FCD domain; Region: FCD; pfam07729 698966005774 Cna protein B-type domain; Region: Cna_B; pfam05738 698966005775 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 698966005776 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698966005777 MULE transposase domain; Region: MULE; pfam10551 698966005778 TQXA domain; Region: TQXA_dom; TIGR03934 698966005779 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 698966005780 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 698966005781 active site 698966005782 intersubunit interface [polypeptide binding]; other site 698966005783 zinc binding site [ion binding]; other site 698966005784 Na+ binding site [ion binding]; other site 698966005785 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 698966005786 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698966005787 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698966005788 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698966005789 active site 698966005790 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698966005791 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698966005792 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698966005793 active site residue [active] 698966005794 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698966005795 active site residue [active] 698966005796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698966005797 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 698966005798 Clp amino terminal domain; Region: Clp_N; pfam02861 698966005799 Clp amino terminal domain; Region: Clp_N; pfam02861 698966005800 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698966005801 Walker A motif; other site 698966005802 ATP binding site [chemical binding]; other site 698966005803 Walker B motif; other site 698966005804 arginine finger; other site 698966005805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698966005806 Walker A motif; other site 698966005807 ATP binding site [chemical binding]; other site 698966005808 Walker B motif; other site 698966005809 arginine finger; other site 698966005810 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698966005811 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698966005812 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 698966005813 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698966005814 Walker A/P-loop; other site 698966005815 ATP binding site [chemical binding]; other site 698966005816 Q-loop/lid; other site 698966005817 ABC transporter signature motif; other site 698966005818 Walker B; other site 698966005819 D-loop; other site 698966005820 H-loop/switch region; other site 698966005821 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698966005822 EamA-like transporter family; Region: EamA; pfam00892 698966005823 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698966005824 EamA-like transporter family; Region: EamA; pfam00892 698966005825 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 698966005826 FAD binding pocket [chemical binding]; other site 698966005827 FAD binding motif [chemical binding]; other site 698966005828 phosphate binding motif [ion binding]; other site 698966005829 beta-alpha-beta structure motif; other site 698966005830 NAD binding pocket [chemical binding]; other site 698966005831 Predicted amidohydrolase [General function prediction only]; Region: COG0388 698966005832 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 698966005833 putative active site [active] 698966005834 catalytic triad [active] 698966005835 putative dimer interface [polypeptide binding]; other site 698966005836 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 698966005837 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 698966005838 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 698966005839 NAD binding site [chemical binding]; other site 698966005840 substrate binding site [chemical binding]; other site 698966005841 catalytic Zn binding site [ion binding]; other site 698966005842 tetramer interface [polypeptide binding]; other site 698966005843 structural Zn binding site [ion binding]; other site 698966005844 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698966005845 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698966005846 NAD(P) binding site [chemical binding]; other site 698966005847 catalytic residues [active] 698966005848 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 698966005849 DNA binding residues [nucleotide binding] 698966005850 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698966005851 putative dimer interface [polypeptide binding]; other site 698966005852 chaperone protein DnaJ; Provisional; Region: PRK14279 698966005853 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698966005854 HSP70 interaction site [polypeptide binding]; other site 698966005855 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698966005856 Zn binding sites [ion binding]; other site 698966005857 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698966005858 dimer interface [polypeptide binding]; other site 698966005859 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 698966005860 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 698966005861 dimer interface [polypeptide binding]; other site 698966005862 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 698966005863 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 698966005864 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 698966005865 nucleotide binding site [chemical binding]; other site 698966005866 NEF interaction site [polypeptide binding]; other site 698966005867 SBD interface [polypeptide binding]; other site 698966005868 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698966005869 PAS domain; Region: PAS_9; pfam13426 698966005870 putative active site [active] 698966005871 heme pocket [chemical binding]; other site 698966005872 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698966005873 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698966005874 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698966005875 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698966005876 Walker A/P-loop; other site 698966005877 ATP binding site [chemical binding]; other site 698966005878 Q-loop/lid; other site 698966005879 ABC transporter signature motif; other site 698966005880 Walker B; other site 698966005881 D-loop; other site 698966005882 H-loop/switch region; other site 698966005883 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698966005884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698966005885 dimer interface [polypeptide binding]; other site 698966005886 conserved gate region; other site 698966005887 putative PBP binding loops; other site 698966005888 ABC-ATPase subunit interface; other site 698966005889 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698966005890 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 698966005891 Walker A/P-loop; other site 698966005892 ATP binding site [chemical binding]; other site 698966005893 Q-loop/lid; other site 698966005894 ABC transporter signature motif; other site 698966005895 Walker B; other site 698966005896 D-loop; other site 698966005897 H-loop/switch region; other site 698966005898 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698966005899 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698966005900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698966005901 dimer interface [polypeptide binding]; other site 698966005902 conserved gate region; other site 698966005903 putative PBP binding loops; other site 698966005904 ABC-ATPase subunit interface; other site 698966005905 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698966005906 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 698966005907 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698966005908 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698966005909 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 698966005910 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 698966005911 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 698966005912 dimerization interface [polypeptide binding]; other site 698966005913 ATP binding site [chemical binding]; other site 698966005914 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 698966005915 dimerization interface [polypeptide binding]; other site 698966005916 ATP binding site [chemical binding]; other site 698966005917 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 698966005918 putative active site [active] 698966005919 catalytic triad [active] 698966005920 potential frameshift: common BLAST hit: gi|32479398|ref|NP_862251.1| Tnp1250a 698966005921 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698966005922 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698966005923 Integrase core domain; Region: rve; pfam00665 698966005924 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 698966005925 FAD binding pocket [chemical binding]; other site 698966005926 FAD binding motif [chemical binding]; other site 698966005927 phosphate binding motif [ion binding]; other site 698966005928 NAD binding pocket [chemical binding]; other site 698966005929 Siderophore-interacting protein; Region: SIP; pfam04954 698966005930 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698966005931 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698966005932 Walker A/P-loop; other site 698966005933 ATP binding site [chemical binding]; other site 698966005934 Q-loop/lid; other site 698966005935 ABC transporter signature motif; other site 698966005936 Walker B; other site 698966005937 D-loop; other site 698966005938 H-loop/switch region; other site 698966005939 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698966005940 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698966005941 ABC-ATPase subunit interface; other site 698966005942 dimer interface [polypeptide binding]; other site 698966005943 putative PBP binding regions; other site 698966005944 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698966005945 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698966005946 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698966005947 ABC-ATPase subunit interface; other site 698966005948 dimer interface [polypeptide binding]; other site 698966005949 putative PBP binding regions; other site 698966005950 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 698966005951 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698966005952 siderophore binding site; other site 698966005953 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 698966005954 ferredoxin-NADP+ reductase; Region: PLN02852 698966005955 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698966005956 4Fe-4S binding domain; Region: Fer4; cl02805 698966005957 Cysteine-rich domain; Region: CCG; pfam02754 698966005958 Cysteine-rich domain; Region: CCG; pfam02754 698966005959 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 698966005960 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698966005961 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 698966005962 putative NAD(P) binding site [chemical binding]; other site 698966005963 catalytic Zn binding site [ion binding]; other site 698966005964 aminotransferase AlaT; Validated; Region: PRK09265 698966005965 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698966005966 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698966005967 homodimer interface [polypeptide binding]; other site 698966005968 catalytic residue [active] 698966005969 YibE/F-like protein; Region: YibE_F; pfam07907 698966005970 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 698966005971 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 698966005972 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698966005973 dimer interface [polypeptide binding]; other site 698966005974 putative anticodon binding site; other site 698966005975 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698966005976 motif 1; other site 698966005977 dimer interface [polypeptide binding]; other site 698966005978 active site 698966005979 motif 2; other site 698966005980 motif 3; other site 698966005981 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698966005982 Protein of unknown function (DUF998); Region: DUF998; pfam06197 698966005983 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 698966005984 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 698966005985 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 698966005986 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698966005987 trimer interface [polypeptide binding]; other site 698966005988 active site 698966005989 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698966005990 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966005991 Walker A/P-loop; other site 698966005992 ATP binding site [chemical binding]; other site 698966005993 Q-loop/lid; other site 698966005994 ABC transporter signature motif; other site 698966005995 Walker B; other site 698966005996 D-loop; other site 698966005997 H-loop/switch region; other site 698966005998 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698966005999 MULE transposase domain; Region: MULE; pfam10551 698966006000 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 698966006001 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698966006002 active site 698966006003 BRO family, N-terminal domain; Region: Bro-N; smart01040 698966006004 Abi-like protein; Region: Abi_2; cl01988 698966006005 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 698966006006 metabolite-proton symporter; Region: 2A0106; TIGR00883 698966006007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966006008 putative substrate translocation pore; other site 698966006009 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698966006010 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698966006011 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 698966006012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966006013 putative substrate translocation pore; other site 698966006014 YwiC-like protein; Region: YwiC; pfam14256 698966006015 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698966006016 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698966006017 VanW like protein; Region: VanW; pfam04294 698966006018 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 698966006019 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 698966006020 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 698966006021 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698966006022 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698966006023 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698966006024 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698966006025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698966006026 S-adenosylmethionine binding site [chemical binding]; other site 698966006027 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 698966006028 active site 698966006029 substrate-binding site [chemical binding]; other site 698966006030 metal-binding site [ion binding] 698966006031 GTP binding site [chemical binding]; other site 698966006032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698966006033 S-adenosylmethionine binding site [chemical binding]; other site 698966006034 LabA_like proteins; Region: LabA_like; cd06167 698966006035 putative metal binding site [ion binding]; other site 698966006036 MMPL family; Region: MMPL; pfam03176 698966006037 MMPL family; Region: MMPL; pfam03176 698966006038 Predicted integral membrane protein [Function unknown]; Region: COG0392 698966006039 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 698966006040 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 698966006041 TQXA domain; Region: TQXA_dom; TIGR03934 698966006042 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 698966006043 active site 698966006044 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698966006045 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698966006046 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698966006047 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698966006048 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 698966006049 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 698966006050 active site 698966006051 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 698966006052 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698966006053 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 698966006054 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 698966006055 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 698966006056 acyl-activating enzyme (AAE) consensus motif; other site 698966006057 active site 698966006058 Cutinase; Region: Cutinase; pfam01083 698966006059 Putative esterase; Region: Esterase; pfam00756 698966006060 S-formylglutathione hydrolase; Region: PLN02442 698966006061 LGFP repeat; Region: LGFP; pfam08310 698966006062 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698966006063 LGFP repeat; Region: LGFP; pfam08310 698966006064 LGFP repeat; Region: LGFP; pfam08310 698966006065 Predicted esterase [General function prediction only]; Region: COG0627 698966006066 S-formylglutathione hydrolase; Region: PLN02442 698966006067 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 698966006068 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 698966006069 UbiA prenyltransferase family; Region: UbiA; pfam01040 698966006070 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698966006071 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698966006072 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698966006073 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698966006074 active site 698966006075 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698966006076 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698966006077 NAD(P) binding site [chemical binding]; other site 698966006078 catalytic residues [active] 698966006079 BCCT family transporter; Region: BCCT; cl00569 698966006080 choline dehydrogenase; Validated; Region: PRK02106 698966006081 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698966006082 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 698966006083 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698966006084 UDP-galactopyranose mutase; Region: GLF; pfam03275 698966006085 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 698966006086 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698966006087 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966006088 ABC transporter signature motif; other site 698966006089 Walker B; other site 698966006090 D-loop; other site 698966006091 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698966006092 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698966006093 amidase catalytic site [active] 698966006094 Zn binding residues [ion binding]; other site 698966006095 substrate binding site [chemical binding]; other site 698966006096 LGFP repeat; Region: LGFP; pfam08310 698966006097 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 698966006098 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 698966006099 CT1975-like protein; Region: Cas_CT1975; pfam09344 698966006100 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 698966006101 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 698966006102 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 698966006103 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698966006104 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 698966006105 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 698966006106 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 698966006107 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698966006108 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698966006109 dimer interface [polypeptide binding]; other site 698966006110 ssDNA binding site [nucleotide binding]; other site 698966006111 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698966006112 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698966006113 active site 698966006114 catalytic site [active] 698966006115 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698966006116 active site 698966006117 catalytic site [active] 698966006118 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698966006119 Cna protein B-type domain; Region: Cna_B; pfam05738 698966006120 Cna protein B-type domain; Region: Cna_B; pfam05738 698966006121 Cna protein B-type domain; Region: Cna_B; pfam05738 698966006122 Cna protein B-type domain; Region: Cna_B; pfam05738 698966006123 Cna protein B-type domain; Region: Cna_B; pfam05738 698966006124 Cna protein B-type domain; Region: Cna_B; pfam05738 698966006125 HTH-like domain; Region: HTH_21; pfam13276 698966006126 potential frameshift: common BLAST hit: gi|227832250|ref|YP_002833957.1| transposase 698966006127 Integrase core domain; Region: rve; pfam00665 698966006128 Integrase core domain; Region: rve_3; cl15866 698966006129 Helix-turn-helix domain; Region: HTH_28; pfam13518 698966006130 putative transposase OrfB; Reviewed; Region: PHA02517 698966006131 HTH-like domain; Region: HTH_21; pfam13276 698966006132 Integrase core domain; Region: rve; pfam00665 698966006133 Integrase core domain; Region: rve_2; pfam13333 698966006134 glycerol kinase; Provisional; Region: glpK; PRK00047 698966006135 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 698966006136 N- and C-terminal domain interface [polypeptide binding]; other site 698966006137 active site 698966006138 MgATP binding site [chemical binding]; other site 698966006139 catalytic site [active] 698966006140 metal binding site [ion binding]; metal-binding site 698966006141 putative homotetramer interface [polypeptide binding]; other site 698966006142 glycerol binding site [chemical binding]; other site 698966006143 homodimer interface [polypeptide binding]; other site 698966006144 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 698966006145 amphipathic channel; other site 698966006146 Asn-Pro-Ala signature motifs; other site 698966006147 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 698966006148 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698966006149 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698966006150 putative acyl-acceptor binding pocket; other site 698966006151 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698966006152 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698966006153 active site 698966006154 motif I; other site 698966006155 motif II; other site 698966006156 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698966006157 seryl-tRNA synthetase; Provisional; Region: PRK05431 698966006158 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 698966006159 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 698966006160 dimer interface [polypeptide binding]; other site 698966006161 active site 698966006162 motif 1; other site 698966006163 motif 2; other site 698966006164 motif 3; other site 698966006165 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698966006166 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698966006167 DNA-binding site [nucleotide binding]; DNA binding site 698966006168 UTRA domain; Region: UTRA; pfam07702 698966006169 Septum formation; Region: Septum_form; pfam13845 698966006170 Septum formation; Region: Septum_form; pfam13845 698966006171 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 698966006172 AAA domain; Region: AAA_14; pfam13173 698966006173 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 698966006174 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698966006175 catalytic core [active] 698966006176 prephenate dehydratase; Provisional; Region: PRK11898 698966006177 Prephenate dehydratase; Region: PDT; pfam00800 698966006178 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 698966006179 putative L-Phe binding site [chemical binding]; other site 698966006180 Amidase; Region: Amidase; cl11426 698966006181 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698966006182 CAAX protease self-immunity; Region: Abi; pfam02517 698966006183 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 698966006184 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698966006185 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698966006186 amino acid carrier protein; Region: agcS; TIGR00835 698966006187 Acyltransferase family; Region: Acyl_transf_3; pfam01757 698966006188 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 698966006189 catalytic triad [active] 698966006190 catalytic triad [active] 698966006191 oxyanion hole [active] 698966006192 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698966006193 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 698966006194 putative active site [active] 698966006195 catalytic site [active] 698966006196 putative metal binding site [ion binding]; other site 698966006197 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 698966006198 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 698966006199 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698966006200 NAD binding site [chemical binding]; other site 698966006201 dimer interface [polypeptide binding]; other site 698966006202 substrate binding site [chemical binding]; other site 698966006203 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 698966006204 nudix motif; other site 698966006205 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 698966006206 quinolinate synthetase; Provisional; Region: PRK09375 698966006207 L-aspartate oxidase; Provisional; Region: PRK06175 698966006208 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 698966006209 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 698966006210 dimerization interface [polypeptide binding]; other site 698966006211 active site 698966006212 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 698966006213 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 698966006214 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 698966006215 Predicted flavoprotein [General function prediction only]; Region: COG0431 698966006216 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698966006217 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 698966006218 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 698966006219 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698966006220 Lsr2; Region: Lsr2; pfam11774 698966006221 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698966006222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698966006223 active site 698966006224 phosphorylation site [posttranslational modification] 698966006225 intermolecular recognition site; other site 698966006226 dimerization interface [polypeptide binding]; other site 698966006227 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698966006228 DNA binding residues [nucleotide binding] 698966006229 dimerization interface [polypeptide binding]; other site 698966006230 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698966006231 Histidine kinase; Region: HisKA_3; pfam07730 698966006232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698966006233 ATP binding site [chemical binding]; other site 698966006234 Mg2+ binding site [ion binding]; other site 698966006235 G-X-G motif; other site 698966006236 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 698966006237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966006238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966006239 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 698966006240 active site 698966006241 catalytic site [active] 698966006242 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 698966006243 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 698966006244 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698966006245 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698966006246 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698966006247 Ligand Binding Site [chemical binding]; other site 698966006248 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698966006249 Ligand Binding Site [chemical binding]; other site 698966006250 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 698966006251 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698966006252 probable active site [active] 698966006253 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698966006254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966006255 Walker A/P-loop; other site 698966006256 ATP binding site [chemical binding]; other site 698966006257 Q-loop/lid; other site 698966006258 ABC transporter signature motif; other site 698966006259 Walker B; other site 698966006260 D-loop; other site 698966006261 H-loop/switch region; other site 698966006262 Predicted transcriptional regulators [Transcription]; Region: COG1725 698966006263 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698966006264 DNA-binding site [nucleotide binding]; DNA binding site 698966006265 LabA_like proteins; Region: LabA_like; cd06167 698966006266 putative metal binding site [ion binding]; other site 698966006267 Uncharacterized conserved protein [Function unknown]; Region: COG1432 698966006268 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698966006269 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698966006270 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698966006271 catalytic residues [active] 698966006272 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698966006273 metal-binding site [ion binding] 698966006274 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698966006275 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698966006276 metal-binding site [ion binding] 698966006277 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698966006278 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698966006279 benzoate transport; Region: 2A0115; TIGR00895 698966006280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966006281 putative substrate translocation pore; other site 698966006282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698966006283 replicative DNA helicase; Provisional; Region: PRK05636 698966006284 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 698966006285 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 698966006286 Walker A motif; other site 698966006287 ATP binding site [chemical binding]; other site 698966006288 Walker B motif; other site 698966006289 DNA binding loops [nucleotide binding] 698966006290 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 698966006291 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 698966006292 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 698966006293 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698966006294 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698966006295 dimer interface [polypeptide binding]; other site 698966006296 ssDNA binding site [nucleotide binding]; other site 698966006297 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698966006298 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 698966006299 Predicted integral membrane protein [Function unknown]; Region: COG5650 698966006300 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698966006301 Transglycosylase; Region: Transgly; pfam00912 698966006302 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698966006303 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698966006304 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698966006305 Ligand Binding Site [chemical binding]; other site 698966006306 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698966006307 Ligand Binding Site [chemical binding]; other site 698966006308 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698966006309 classical (c) SDRs; Region: SDR_c; cd05233 698966006310 NAD(P) binding site [chemical binding]; other site 698966006311 active site 698966006312 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698966006313 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698966006314 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 698966006315 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 698966006316 active site residue [active] 698966006317 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 698966006318 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698966006319 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 698966006320 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 698966006321 dimerization interface [polypeptide binding]; other site 698966006322 DPS ferroxidase diiron center [ion binding]; other site 698966006323 ion pore; other site 698966006324 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698966006325 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 698966006326 putative DNA binding site [nucleotide binding]; other site 698966006327 catalytic residue [active] 698966006328 putative H2TH interface [polypeptide binding]; other site 698966006329 putative catalytic residues [active] 698966006330 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698966006331 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698966006332 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 698966006333 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 698966006334 putative substrate binding site [chemical binding]; other site 698966006335 putative ATP binding site [chemical binding]; other site 698966006336 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 698966006337 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 698966006338 active site 698966006339 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698966006340 AAA domain; Region: AAA_31; pfam13614 698966006341 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698966006342 P-loop; other site 698966006343 Magnesium ion binding site [ion binding]; other site 698966006344 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698966006345 Magnesium ion binding site [ion binding]; other site 698966006346 MarR family; Region: MarR_2; cl17246 698966006347 Divergent AAA domain; Region: AAA_4; pfam04326 698966006348 Divergent AAA domain; Region: AAA_4; pfam04326 698966006349 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698966006350 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698966006351 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 698966006352 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698966006353 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698966006354 ATP binding site [chemical binding]; other site 698966006355 putative Mg++ binding site [ion binding]; other site 698966006356 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 698966006357 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 698966006358 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698966006359 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698966006360 HsdM N-terminal domain; Region: HsdM_N; pfam12161 698966006361 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 698966006362 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698966006363 Fic family protein [Function unknown]; Region: COG3177 698966006364 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698966006365 Fic/DOC family; Region: Fic; pfam02661 698966006366 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 698966006367 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 698966006368 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 698966006369 E-class dimer interface [polypeptide binding]; other site 698966006370 P-class dimer interface [polypeptide binding]; other site 698966006371 active site 698966006372 Cu2+ binding site [ion binding]; other site 698966006373 Zn2+ binding site [ion binding]; other site 698966006374 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 698966006375 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698966006376 active site 698966006377 HIGH motif; other site 698966006378 nucleotide binding site [chemical binding]; other site 698966006379 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698966006380 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698966006381 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698966006382 active site 698966006383 KMSKS motif; other site 698966006384 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 698966006385 tRNA binding surface [nucleotide binding]; other site 698966006386 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698966006387 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698966006388 Walker A/P-loop; other site 698966006389 ATP binding site [chemical binding]; other site 698966006390 Q-loop/lid; other site 698966006391 ABC transporter signature motif; other site 698966006392 Walker B; other site 698966006393 D-loop; other site 698966006394 H-loop/switch region; other site 698966006395 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698966006396 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698966006397 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698966006398 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698966006399 Histidine kinase; Region: HisKA_3; pfam07730 698966006400 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698966006401 ATP binding site [chemical binding]; other site 698966006402 G-X-G motif; other site 698966006403 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698966006404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698966006405 active site 698966006406 phosphorylation site [posttranslational modification] 698966006407 intermolecular recognition site; other site 698966006408 dimerization interface [polypeptide binding]; other site 698966006409 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698966006410 DNA binding residues [nucleotide binding] 698966006411 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698966006412 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698966006413 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698966006414 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698966006415 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698966006416 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698966006417 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698966006418 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698966006419 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 698966006420 NAD(P) binding site [chemical binding]; other site 698966006421 catalytic residues [active] 698966006422 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698966006423 active site 698966006424 phosphorylation site [posttranslational modification] 698966006425 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 698966006426 active site 698966006427 P-loop; other site 698966006428 phosphorylation site [posttranslational modification] 698966006429 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 698966006430 Putative esterase; Region: Esterase; pfam00756 698966006431 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 698966006432 active site 698966006433 Cobalt transport protein; Region: CbiQ; cl00463 698966006434 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966006435 ABC transporter signature motif; other site 698966006436 Walker B; other site 698966006437 D-loop; other site 698966006438 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698966006439 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698966006440 Walker A/P-loop; other site 698966006441 ATP binding site [chemical binding]; other site 698966006442 Q-loop/lid; other site 698966006443 ABC transporter signature motif; other site 698966006444 Walker B; other site 698966006445 D-loop; other site 698966006446 H-loop/switch region; other site 698966006447 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 698966006448 active site 698966006449 catalytic residues [active] 698966006450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 698966006451 hypothetical protein; Provisional; Region: PRK13663 698966006452 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698966006453 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698966006454 putative active site [active] 698966006455 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698966006456 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698966006457 SdpI/YhfL protein family; Region: SdpI; pfam13630 698966006458 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698966006459 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698966006460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698966006461 catalytic residue [active] 698966006462 anthranilate synthase component I; Provisional; Region: PRK13564 698966006463 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 698966006464 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698966006465 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698966006466 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698966006467 glutamine binding [chemical binding]; other site 698966006468 catalytic triad [active] 698966006469 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 698966006470 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698966006471 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698966006472 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 698966006473 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698966006474 active site 698966006475 ribulose/triose binding site [chemical binding]; other site 698966006476 phosphate binding site [ion binding]; other site 698966006477 substrate (anthranilate) binding pocket [chemical binding]; other site 698966006478 product (indole) binding pocket [chemical binding]; other site 698966006479 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 698966006480 active site 698966006481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 698966006482 pantoate--beta-alanine ligase; Region: panC; TIGR00018 698966006483 Pantoate-beta-alanine ligase; Region: PanC; cd00560 698966006484 active site 698966006485 ATP-binding site [chemical binding]; other site 698966006486 pantoate-binding site; other site 698966006487 HXXH motif; other site 698966006488 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 698966006489 oligomerization interface [polypeptide binding]; other site 698966006490 active site 698966006491 metal binding site [ion binding]; metal-binding site 698966006492 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698966006493 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698966006494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698966006495 catalytic residue [active] 698966006496 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 698966006497 substrate binding site [chemical binding]; other site 698966006498 active site 698966006499 catalytic residues [active] 698966006500 heterodimer interface [polypeptide binding]; other site 698966006501 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698966006502 iron-sulfur cluster [ion binding]; other site 698966006503 [2Fe-2S] cluster binding site [ion binding]; other site 698966006504 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 698966006505 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698966006506 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 698966006507 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 698966006508 hypothetical protein; Validated; Region: PRK00228 698966006509 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 698966006510 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 698966006511 active site 698966006512 NTP binding site [chemical binding]; other site 698966006513 metal binding triad [ion binding]; metal-binding site 698966006514 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 698966006515 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698966006516 Zn2+ binding site [ion binding]; other site 698966006517 Mg2+ binding site [ion binding]; other site 698966006518 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 698966006519 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698966006520 active site 698966006521 Ap6A binding site [chemical binding]; other site 698966006522 nudix motif; other site 698966006523 metal binding site [ion binding]; metal-binding site 698966006524 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 698966006525 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 698966006526 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 698966006527 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698966006528 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698966006529 DNA binding residues [nucleotide binding] 698966006530 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 698966006531 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698966006532 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698966006533 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698966006534 catalytic residues [active] 698966006535 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698966006536 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698966006537 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 698966006538 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 698966006539 active site 698966006540 metal binding site [ion binding]; metal-binding site 698966006541 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 698966006542 ParB-like nuclease domain; Region: ParBc; pfam02195 698966006543 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698966006544 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698966006545 P-loop; other site 698966006546 Magnesium ion binding site [ion binding]; other site 698966006547 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698966006548 Magnesium ion binding site [ion binding]; other site 698966006549 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 698966006550 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 698966006551 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 698966006552 ribonuclease P; Reviewed; Region: rnpA; PRK03459 698966006553 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399