-- dump date 20140619_050740 -- class Genbank::misc_feature -- table misc_feature_note -- id note 698973000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 698973000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698973000003 Walker A motif; other site 698973000004 ATP binding site [chemical binding]; other site 698973000005 Walker B motif; other site 698973000006 arginine finger; other site 698973000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 698973000008 DnaA box-binding interface [nucleotide binding]; other site 698973000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 698973000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 698973000011 putative DNA binding surface [nucleotide binding]; other site 698973000012 dimer interface [polypeptide binding]; other site 698973000013 beta-clamp/clamp loader binding surface; other site 698973000014 beta-clamp/translesion DNA polymerase binding surface; other site 698973000015 recombination protein F; Reviewed; Region: recF; PRK00064 698973000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 698973000017 Walker A/P-loop; other site 698973000018 ATP binding site [chemical binding]; other site 698973000019 Q-loop/lid; other site 698973000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973000021 ABC transporter signature motif; other site 698973000022 Walker B; other site 698973000023 D-loop; other site 698973000024 H-loop/switch region; other site 698973000025 hypothetical protein; Provisional; Region: PRK00111 698973000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 698973000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698973000028 ATP binding site [chemical binding]; other site 698973000029 Mg2+ binding site [ion binding]; other site 698973000030 G-X-G motif; other site 698973000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698973000032 anchoring element; other site 698973000033 dimer interface [polypeptide binding]; other site 698973000034 ATP binding site [chemical binding]; other site 698973000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 698973000036 active site 698973000037 putative metal-binding site [ion binding]; other site 698973000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698973000039 DNA gyrase subunit A; Validated; Region: PRK05560 698973000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 698973000041 CAP-like domain; other site 698973000042 active site 698973000043 primary dimer interface [polypeptide binding]; other site 698973000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698973000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698973000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698973000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698973000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698973000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698973000050 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 698973000051 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698973000052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698973000053 DNA-binding site [nucleotide binding]; DNA binding site 698973000054 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698973000055 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698973000056 L-lactate permease; Region: Lactate_perm; cl00701 698973000057 Cadherin repeat-like domain; Region: CA_like; cl15786 698973000058 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698973000059 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698973000060 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 698973000061 Walker A/P-loop; other site 698973000062 ATP binding site [chemical binding]; other site 698973000063 Q-loop/lid; other site 698973000064 ABC transporter signature motif; other site 698973000065 Walker B; other site 698973000066 D-loop; other site 698973000067 H-loop/switch region; other site 698973000068 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698973000069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973000070 Walker A/P-loop; other site 698973000071 ATP binding site [chemical binding]; other site 698973000072 Q-loop/lid; other site 698973000073 ABC transporter signature motif; other site 698973000074 Walker B; other site 698973000075 D-loop; other site 698973000076 H-loop/switch region; other site 698973000077 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698973000078 active site 698973000079 catalytic site [active] 698973000080 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 698973000081 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698973000082 putative ligand binding site [chemical binding]; other site 698973000083 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698973000084 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698973000085 TM-ABC transporter signature motif; other site 698973000086 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698973000087 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698973000088 Walker A/P-loop; other site 698973000089 ATP binding site [chemical binding]; other site 698973000090 Q-loop/lid; other site 698973000091 ABC transporter signature motif; other site 698973000092 Walker B; other site 698973000093 D-loop; other site 698973000094 H-loop/switch region; other site 698973000095 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698973000096 active site 698973000097 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698973000098 Helix-turn-helix domain; Region: HTH_28; pfam13518 698973000099 Integrase core domain; Region: rve_3; cl15866 698973000100 Rhomboid family; Region: Rhomboid; pfam01694 698973000101 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 698973000102 ThiC-associated domain; Region: ThiC-associated; pfam13667 698973000103 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 698973000104 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698973000105 thiamine phosphate binding site [chemical binding]; other site 698973000106 active site 698973000107 pyrophosphate binding site [ion binding]; other site 698973000108 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698973000109 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 698973000110 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 698973000111 thiS-thiF/thiG interaction site; other site 698973000112 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 698973000113 ThiS interaction site; other site 698973000114 putative active site [active] 698973000115 tetramer interface [polypeptide binding]; other site 698973000116 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 698973000117 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698973000118 ATP binding site [chemical binding]; other site 698973000119 substrate interface [chemical binding]; other site 698973000120 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 698973000121 active site residue [active] 698973000122 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 698973000123 dimer interface [polypeptide binding]; other site 698973000124 substrate binding site [chemical binding]; other site 698973000125 ATP binding site [chemical binding]; other site 698973000126 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 698973000127 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 698973000128 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 698973000129 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 698973000130 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 698973000131 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698973000132 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698973000133 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698973000134 MULE transposase domain; Region: MULE; pfam10551 698973000135 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698973000136 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698973000137 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698973000138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698973000139 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698973000140 non-specific DNA binding site [nucleotide binding]; other site 698973000141 salt bridge; other site 698973000142 sequence-specific DNA binding site [nucleotide binding]; other site 698973000143 putative septation inhibitor protein; Reviewed; Region: PRK00159 698973000144 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698973000145 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698973000146 active site 698973000147 ATP binding site [chemical binding]; other site 698973000148 substrate binding site [chemical binding]; other site 698973000149 activation loop (A-loop); other site 698973000150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698973000151 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698973000152 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698973000153 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698973000154 PASTA domain; Region: PASTA; pfam03793 698973000155 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698973000156 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698973000157 active site 698973000158 ATP binding site [chemical binding]; other site 698973000159 substrate binding site [chemical binding]; other site 698973000160 activation loop (A-loop); other site 698973000161 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698973000162 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698973000163 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698973000164 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 698973000165 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 698973000166 Protein phosphatase 2C; Region: PP2C; pfam00481 698973000167 active site 698973000168 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698973000169 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698973000170 phosphopeptide binding site; other site 698973000171 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 698973000172 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698973000173 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698973000174 phosphopeptide binding site; other site 698973000175 DDE domain; Region: DDE_Tnp_IS240; pfam13610 698973000176 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 698973000177 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 698973000178 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698973000179 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698973000180 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698973000181 metal-binding site [ion binding] 698973000182 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698973000183 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698973000184 dimerization interface [polypeptide binding]; other site 698973000185 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698973000186 dimer interface [polypeptide binding]; other site 698973000187 phosphorylation site [posttranslational modification] 698973000188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698973000189 ATP binding site [chemical binding]; other site 698973000190 Mg2+ binding site [ion binding]; other site 698973000191 G-X-G motif; other site 698973000192 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698973000193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698973000194 active site 698973000195 phosphorylation site [posttranslational modification] 698973000196 intermolecular recognition site; other site 698973000197 dimerization interface [polypeptide binding]; other site 698973000198 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698973000199 DNA binding site [nucleotide binding] 698973000200 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 698973000201 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 698973000202 Multicopper oxidase; Region: Cu-oxidase; pfam00394 698973000203 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 698973000204 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698973000205 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698973000206 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698973000207 dimerization interface [polypeptide binding]; other site 698973000208 putative DNA binding site [nucleotide binding]; other site 698973000209 putative Zn2+ binding site [ion binding]; other site 698973000210 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 698973000211 Cadmium resistance transporter; Region: Cad; pfam03596 698973000212 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 698973000213 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 698973000214 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698973000215 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698973000216 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698973000217 mercuric reductase; Region: MerA; TIGR02053 698973000218 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698973000219 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698973000220 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698973000221 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698973000222 catalytic residues [active] 698973000223 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698973000224 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 698973000225 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 698973000226 DNA binding residues [nucleotide binding] 698973000227 dimer interface [polypeptide binding]; other site 698973000228 metal binding site [ion binding]; metal-binding site 698973000229 NIPSNAP; Region: NIPSNAP; pfam07978 698973000230 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 698973000231 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 698973000232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698973000233 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 698973000234 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698973000235 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 698973000236 arsenical-resistance protein; Region: acr3; TIGR00832 698973000237 Low molecular weight phosphatase family; Region: LMWPc; cl00105 698973000238 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 698973000239 active site 698973000240 Predicted permeases [General function prediction only]; Region: COG0701 698973000241 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698973000242 dimerization interface [polypeptide binding]; other site 698973000243 putative DNA binding site [nucleotide binding]; other site 698973000244 putative Zn2+ binding site [ion binding]; other site 698973000245 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698973000246 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698973000247 non-specific DNA binding site [nucleotide binding]; other site 698973000248 salt bridge; other site 698973000249 sequence-specific DNA binding site [nucleotide binding]; other site 698973000250 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 698973000251 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 698973000252 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 698973000253 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 698973000254 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698973000255 Walker A/P-loop; other site 698973000256 ATP binding site [chemical binding]; other site 698973000257 Q-loop/lid; other site 698973000258 ABC transporter signature motif; other site 698973000259 Walker B; other site 698973000260 D-loop; other site 698973000261 H-loop/switch region; other site 698973000262 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698973000263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698973000264 active site 698973000265 phosphorylation site [posttranslational modification] 698973000266 intermolecular recognition site; other site 698973000267 dimerization interface [polypeptide binding]; other site 698973000268 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698973000269 DNA binding residues [nucleotide binding] 698973000270 dimerization interface [polypeptide binding]; other site 698973000271 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698973000272 Histidine kinase; Region: HisKA_3; pfam07730 698973000273 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698973000274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698973000275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698973000276 dimer interface [polypeptide binding]; other site 698973000277 conserved gate region; other site 698973000278 putative PBP binding loops; other site 698973000279 ABC-ATPase subunit interface; other site 698973000280 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 698973000281 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 698973000282 Walker A/P-loop; other site 698973000283 ATP binding site [chemical binding]; other site 698973000284 Q-loop/lid; other site 698973000285 ABC transporter signature motif; other site 698973000286 Walker B; other site 698973000287 D-loop; other site 698973000288 H-loop/switch region; other site 698973000289 Anti-sigma-K factor rskA; Region: RskA; pfam10099 698973000290 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 698973000291 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698973000292 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698973000293 DNA binding residues [nucleotide binding] 698973000294 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698973000295 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698973000296 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 698973000297 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698973000298 catalytic residues [active] 698973000299 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 698973000300 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698973000301 DNA binding residues [nucleotide binding] 698973000302 dimer interface [polypeptide binding]; other site 698973000303 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 698973000304 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 698973000305 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 698973000306 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 698973000307 putative metal binding site [ion binding]; other site 698973000308 biotin synthase; Validated; Region: PRK06256 698973000309 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698973000310 FeS/SAM binding site; other site 698973000311 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698973000312 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 698973000313 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 698973000314 putative ligand binding residues [chemical binding]; other site 698973000315 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698973000316 ABC-ATPase subunit interface; other site 698973000317 dimer interface [polypeptide binding]; other site 698973000318 putative PBP binding regions; other site 698973000319 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698973000320 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698973000321 Walker A/P-loop; other site 698973000322 ATP binding site [chemical binding]; other site 698973000323 Q-loop/lid; other site 698973000324 ABC transporter signature motif; other site 698973000325 Walker B; other site 698973000326 D-loop; other site 698973000327 H-loop/switch region; other site 698973000328 Uncharacterized conserved protein [Function unknown]; Region: COG5646 698973000329 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 698973000330 DNA photolyase; Region: DNA_photolyase; pfam00875 698973000331 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 698973000332 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 698973000333 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 698973000334 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 698973000335 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 698973000336 Lipase (class 2); Region: Lipase_2; pfam01674 698973000337 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 698973000338 dimer interface [polypeptide binding]; other site 698973000339 FMN binding site [chemical binding]; other site 698973000340 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698973000341 Divergent AAA domain; Region: AAA_4; pfam04326 698973000342 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698973000343 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698973000344 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 698973000345 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 698973000346 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 698973000347 trimer interface [polypeptide binding]; other site 698973000348 putative metal binding site [ion binding]; other site 698973000349 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698973000350 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 698973000351 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 698973000352 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 698973000353 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698973000354 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698973000355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 698973000356 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698973000357 MarR family; Region: MarR; pfam01047 698973000358 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698973000359 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698973000360 hypothetical protein; Provisional; Region: PRK10621 698973000361 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698973000362 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 698973000363 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698973000364 ATP binding site [chemical binding]; other site 698973000365 putative Mg++ binding site [ion binding]; other site 698973000366 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698973000367 nucleotide binding region [chemical binding]; other site 698973000368 Helicase associated domain (HA2); Region: HA2; pfam04408 698973000369 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 698973000370 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 698973000371 maltose O-acetyltransferase; Provisional; Region: PRK10092 698973000372 active site 698973000373 substrate binding site [chemical binding]; other site 698973000374 trimer interface [polypeptide binding]; other site 698973000375 CoA binding site [chemical binding]; other site 698973000376 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698973000377 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 698973000378 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698973000379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698973000380 NAD(P) binding site [chemical binding]; other site 698973000381 active site 698973000382 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698973000383 potential frameshift: common BLAST hit: gi|336325819|ref|YP_004605785.1| transposase for insertion sequence element 698973000384 Helix-turn-helix domain; Region: HTH_38; pfam13936 698973000385 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698973000386 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698973000387 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698973000388 HTH-like domain; Region: HTH_21; pfam13276 698973000389 Integrase core domain; Region: rve; pfam00665 698973000390 Integrase core domain; Region: rve_2; pfam13333 698973000391 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698973000392 Integrase core domain; Region: rve; pfam00665 698973000393 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 698973000394 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698973000395 RNA binding surface [nucleotide binding]; other site 698973000396 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698973000397 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698973000398 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698973000399 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 698973000400 active site 698973000401 DNA binding site [nucleotide binding] 698973000402 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 698973000403 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 698973000404 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 698973000405 active site 698973000406 Zn binding site [ion binding]; other site 698973000407 Protease prsW family; Region: PrsW-protease; pfam13367 698973000408 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698973000409 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 698973000410 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 698973000411 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 698973000412 short chain dehydrogenase; Provisional; Region: PRK07904 698973000413 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698973000414 NAD(P) binding site [chemical binding]; other site 698973000415 active site 698973000416 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698973000417 FAD binding domain; Region: FAD_binding_4; pfam01565 698973000418 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 698973000419 Predicted membrane protein [Function unknown]; Region: COG2246 698973000420 GtrA-like protein; Region: GtrA; pfam04138 698973000421 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698973000422 putative active site [active] 698973000423 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698973000424 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698973000425 active site 698973000426 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698973000427 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698973000428 intersubunit interface [polypeptide binding]; other site 698973000429 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698973000430 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698973000431 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698973000432 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698973000433 ABC-ATPase subunit interface; other site 698973000434 dimer interface [polypeptide binding]; other site 698973000435 putative PBP binding regions; other site 698973000436 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698973000437 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698973000438 ABC-ATPase subunit interface; other site 698973000439 dimer interface [polypeptide binding]; other site 698973000440 putative PBP binding regions; other site 698973000441 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698973000442 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698973000443 intersubunit interface [polypeptide binding]; other site 698973000444 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 698973000445 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 698973000446 Walker A/P-loop; other site 698973000447 ATP binding site [chemical binding]; other site 698973000448 Q-loop/lid; other site 698973000449 ABC transporter signature motif; other site 698973000450 Walker B; other site 698973000451 D-loop; other site 698973000452 H-loop/switch region; other site 698973000453 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 698973000454 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698973000455 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698973000456 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698973000457 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698973000458 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 698973000459 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 698973000460 NAD(P) binding site [chemical binding]; other site 698973000461 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 698973000462 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698973000463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698973000464 homodimer interface [polypeptide binding]; other site 698973000465 catalytic residue [active] 698973000466 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 698973000467 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 698973000468 transmembrane helices; other site 698973000469 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698973000470 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 698973000471 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698973000472 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698973000473 DNA-binding site [nucleotide binding]; DNA binding site 698973000474 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698973000475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698973000476 homodimer interface [polypeptide binding]; other site 698973000477 catalytic residue [active] 698973000478 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 698973000479 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 698973000480 active site 698973000481 multimer interface [polypeptide binding]; other site 698973000482 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 698973000483 predicted active site [active] 698973000484 catalytic triad [active] 698973000485 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698973000486 active site 698973000487 catalytic site [active] 698973000488 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698973000489 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698973000490 active site 698973000491 catalytic site [active] 698973000492 HTH-like domain; Region: HTH_21; pfam13276 698973000493 Integrase core domain; Region: rve; pfam00665 698973000494 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698973000495 Helix-turn-helix domain; Region: HTH_38; pfam13936 698973000496 Integrase core domain; Region: rve; pfam00665 698973000497 Transposase; Region: HTH_Tnp_1; cl17663 698973000498 prephenate dehydrogenase; Validated; Region: PRK06545 698973000499 prephenate dehydrogenase; Validated; Region: PRK08507 698973000500 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 698973000501 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 698973000502 nucleoside/Zn binding site; other site 698973000503 dimer interface [polypeptide binding]; other site 698973000504 catalytic motif [active] 698973000505 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 698973000506 DNA binding residues [nucleotide binding] 698973000507 PIN domain; Region: PIN_3; pfam13470 698973000508 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 698973000509 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 698973000510 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 698973000511 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 698973000512 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 698973000513 active site 698973000514 HIGH motif; other site 698973000515 nucleotide binding site [chemical binding]; other site 698973000516 active site 698973000517 KMSKS motif; other site 698973000518 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 698973000519 fructuronate transporter; Provisional; Region: PRK10034; cl15264 698973000520 Shikimate kinase; Region: SKI; pfam01202 698973000521 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 698973000522 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 698973000523 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 698973000524 putative NAD(P) binding site [chemical binding]; other site 698973000525 catalytic Zn binding site [ion binding]; other site 698973000526 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 698973000527 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 698973000528 NADP binding site [chemical binding]; other site 698973000529 homodimer interface [polypeptide binding]; other site 698973000530 active site 698973000531 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 698973000532 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698973000533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698973000534 homodimer interface [polypeptide binding]; other site 698973000535 catalytic residue [active] 698973000536 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 698973000537 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 698973000538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698973000539 Walker A motif; other site 698973000540 ATP binding site [chemical binding]; other site 698973000541 Walker B motif; other site 698973000542 arginine finger; other site 698973000543 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 698973000544 hypothetical protein; Validated; Region: PRK00153 698973000545 recombination protein RecR; Reviewed; Region: recR; PRK00076 698973000546 RecR protein; Region: RecR; pfam02132 698973000547 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 698973000548 putative active site [active] 698973000549 putative metal-binding site [ion binding]; other site 698973000550 tetramer interface [polypeptide binding]; other site 698973000551 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698973000552 catalytic triad [active] 698973000553 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 698973000554 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698973000555 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 698973000556 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 698973000557 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698973000558 active site 698973000559 catalytic site [active] 698973000560 substrate binding site [chemical binding]; other site 698973000561 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 698973000562 dimer interface [polypeptide binding]; other site 698973000563 FMN binding site [chemical binding]; other site 698973000564 NADPH bind site [chemical binding]; other site 698973000565 2-isopropylmalate synthase; Validated; Region: PRK03739 698973000566 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 698973000567 active site 698973000568 catalytic residues [active] 698973000569 metal binding site [ion binding]; metal-binding site 698973000570 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 698973000571 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698973000572 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698973000573 DNA binding residues [nucleotide binding] 698973000574 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698973000575 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698973000576 active site 698973000577 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 698973000578 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698973000579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973000580 putative substrate translocation pore; other site 698973000581 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 698973000582 intersubunit interface [polypeptide binding]; other site 698973000583 active site 698973000584 catalytic residue [active] 698973000585 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 698973000586 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 698973000587 active site 698973000588 substrate binding site [chemical binding]; other site 698973000589 metal binding site [ion binding]; metal-binding site 698973000590 aspartate kinase; Reviewed; Region: PRK06635 698973000591 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 698973000592 putative nucleotide binding site [chemical binding]; other site 698973000593 putative catalytic residues [active] 698973000594 putative Mg ion binding site [ion binding]; other site 698973000595 putative aspartate binding site [chemical binding]; other site 698973000596 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 698973000597 putative allosteric regulatory site; other site 698973000598 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 698973000599 putative allosteric regulatory residue; other site 698973000600 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 698973000601 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698973000602 RNA polymerase sigma factor; Provisional; Region: PRK12535 698973000603 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698973000604 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698973000605 DNA binding residues [nucleotide binding] 698973000606 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 698973000607 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 698973000608 heme binding pocket [chemical binding]; other site 698973000609 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698973000610 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 698973000611 Walker A/P-loop; other site 698973000612 ATP binding site [chemical binding]; other site 698973000613 Q-loop/lid; other site 698973000614 ABC transporter signature motif; other site 698973000615 Walker B; other site 698973000616 D-loop; other site 698973000617 H-loop/switch region; other site 698973000618 TOBE domain; Region: TOBE_2; pfam08402 698973000619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698973000620 dimer interface [polypeptide binding]; other site 698973000621 conserved gate region; other site 698973000622 ABC-ATPase subunit interface; other site 698973000623 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698973000624 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 698973000625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973000626 putative substrate translocation pore; other site 698973000627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973000628 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698973000629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698973000630 active site 698973000631 phosphorylation site [posttranslational modification] 698973000632 intermolecular recognition site; other site 698973000633 dimerization interface [polypeptide binding]; other site 698973000634 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698973000635 DNA binding site [nucleotide binding] 698973000636 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698973000637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698973000638 dimer interface [polypeptide binding]; other site 698973000639 phosphorylation site [posttranslational modification] 698973000640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698973000641 ATP binding site [chemical binding]; other site 698973000642 Mg2+ binding site [ion binding]; other site 698973000643 G-X-G motif; other site 698973000644 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 698973000645 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 698973000646 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 698973000647 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 698973000648 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698973000649 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 698973000650 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 698973000651 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698973000652 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 698973000653 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698973000654 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698973000655 Predicted membrane protein [Function unknown]; Region: COG1511 698973000656 Predicted membrane protein [Function unknown]; Region: COG1511 698973000657 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698973000658 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698973000659 putative active site [active] 698973000660 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 698973000661 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698973000662 putative active site [active] 698973000663 putative metal binding site [ion binding]; other site 698973000664 Yqey-like protein; Region: YqeY; pfam09424 698973000665 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698973000666 Transglycosylase; Region: Transgly; pfam00912 698973000667 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698973000668 PASTA domain; Region: PASTA; pfam03793 698973000669 Transcription factor WhiB; Region: Whib; pfam02467 698973000670 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 698973000671 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 698973000672 homotrimer interaction site [polypeptide binding]; other site 698973000673 putative active site [active] 698973000674 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698973000675 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698973000676 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698973000677 ligand binding site [chemical binding]; other site 698973000678 flexible hinge region; other site 698973000679 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698973000680 putative switch regulator; other site 698973000681 non-specific DNA interactions [nucleotide binding]; other site 698973000682 DNA binding site [nucleotide binding] 698973000683 sequence specific DNA binding site [nucleotide binding]; other site 698973000684 putative cAMP binding site [chemical binding]; other site 698973000685 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 698973000686 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698973000687 minor groove reading motif; other site 698973000688 helix-hairpin-helix signature motif; other site 698973000689 substrate binding pocket [chemical binding]; other site 698973000690 active site 698973000691 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698973000692 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698973000693 catalytic residues [active] 698973000694 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 698973000695 putative active site [active] 698973000696 putative CoA binding site [chemical binding]; other site 698973000697 nudix motif; other site 698973000698 metal binding site [ion binding]; metal-binding site 698973000699 Colicin V production protein; Region: Colicin_V; pfam02674 698973000700 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 698973000701 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698973000702 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698973000703 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698973000704 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 698973000705 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698973000706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698973000707 motif II; other site 698973000708 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 698973000709 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 698973000710 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 698973000711 ATP binding site [chemical binding]; other site 698973000712 Walker A motif; other site 698973000713 hexamer interface [polypeptide binding]; other site 698973000714 Walker B motif; other site 698973000715 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 698973000716 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 698973000717 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 698973000718 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 698973000719 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698973000720 ATP binding site [chemical binding]; other site 698973000721 putative Mg++ binding site [ion binding]; other site 698973000722 nucleotide binding region [chemical binding]; other site 698973000723 helicase superfamily c-terminal domain; Region: HELICc; smart00490 698973000724 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 698973000725 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698973000726 DNA-binding site [nucleotide binding]; DNA binding site 698973000727 RNA-binding motif; other site 698973000728 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698973000729 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698973000730 Walker A/P-loop; other site 698973000731 ATP binding site [chemical binding]; other site 698973000732 Q-loop/lid; other site 698973000733 ABC transporter signature motif; other site 698973000734 Walker B; other site 698973000735 D-loop; other site 698973000736 H-loop/switch region; other site 698973000737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973000738 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698973000739 putative substrate translocation pore; other site 698973000740 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698973000741 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 698973000742 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698973000743 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 698973000744 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698973000745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698973000746 dimer interface [polypeptide binding]; other site 698973000747 conserved gate region; other site 698973000748 putative PBP binding loops; other site 698973000749 ABC-ATPase subunit interface; other site 698973000750 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698973000751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698973000752 NAD(P) binding site [chemical binding]; other site 698973000753 active site 698973000754 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 698973000755 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 698973000756 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 698973000757 active site 698973000758 interdomain interaction site; other site 698973000759 putative metal-binding site [ion binding]; other site 698973000760 nucleotide binding site [chemical binding]; other site 698973000761 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 698973000762 domain I; other site 698973000763 DNA binding groove [nucleotide binding] 698973000764 phosphate binding site [ion binding]; other site 698973000765 domain II; other site 698973000766 domain III; other site 698973000767 nucleotide binding site [chemical binding]; other site 698973000768 catalytic site [active] 698973000769 domain IV; other site 698973000770 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 698973000771 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698973000772 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698973000773 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698973000774 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698973000775 active site 698973000776 Predicted membrane protein [Function unknown]; Region: COG1297 698973000777 putative oligopeptide transporter, OPT family; Region: TIGR00733 698973000778 Laminin G domain; Region: Laminin_G_2; pfam02210 698973000779 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698973000780 catalytic site [active] 698973000781 BNR repeat-like domain; Region: BNR_2; pfam13088 698973000782 Asp-box motif; other site 698973000783 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698973000784 dimerization interface [polypeptide binding]; other site 698973000785 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698973000786 cyclase homology domain; Region: CHD; cd07302 698973000787 nucleotidyl binding site; other site 698973000788 metal binding site [ion binding]; metal-binding site 698973000789 dimer interface [polypeptide binding]; other site 698973000790 DNA polymerase III subunit delta'; Validated; Region: PRK07940 698973000791 DNA polymerase III subunit delta'; Validated; Region: PRK08485 698973000792 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 698973000793 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 698973000794 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698973000795 active site 698973000796 catalytic residues [active] 698973000797 DNA binding site [nucleotide binding] 698973000798 Int/Topo IB signature motif; other site 698973000799 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 698973000800 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698973000801 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698973000802 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698973000803 Fic family protein [Function unknown]; Region: COG3177 698973000804 Fic/DOC family; Region: Fic; pfam02661 698973000805 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698973000806 Trypsin; Region: Trypsin; pfam00089 698973000807 active site 698973000808 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 698973000809 putative DNA binding site [nucleotide binding]; other site 698973000810 putative Zn2+ binding site [ion binding]; other site 698973000811 Integrase core domain; Region: rve; pfam00665 698973000812 acyl-CoA synthetase; Validated; Region: PRK07788 698973000813 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698973000814 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698973000815 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698973000816 acyl-activating enzyme (AAE) consensus motif; other site 698973000817 acyl-activating enzyme (AAE) consensus motif; other site 698973000818 AMP binding site [chemical binding]; other site 698973000819 active site 698973000820 CoA binding site [chemical binding]; other site 698973000821 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 698973000822 active site 698973000823 catalytic triad [active] 698973000824 oxyanion hole [active] 698973000825 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 698973000826 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 698973000827 substrate binding site; other site 698973000828 tetramer interface; other site 698973000829 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 698973000830 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 698973000831 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 698973000832 NADP binding site [chemical binding]; other site 698973000833 active site 698973000834 putative substrate binding site [chemical binding]; other site 698973000835 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 698973000836 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 698973000837 NAD binding site [chemical binding]; other site 698973000838 substrate binding site [chemical binding]; other site 698973000839 homodimer interface [polypeptide binding]; other site 698973000840 active site 698973000841 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 698973000842 Zn binding site [ion binding]; other site 698973000843 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 698973000844 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698973000845 Putative esterase; Region: Esterase; pfam00756 698973000846 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 698973000847 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 698973000848 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698973000849 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698973000850 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698973000851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698973000852 non-specific DNA binding site [nucleotide binding]; other site 698973000853 salt bridge; other site 698973000854 sequence-specific DNA binding site [nucleotide binding]; other site 698973000855 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 698973000856 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698973000857 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 698973000858 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 698973000859 putative Iron-sulfur protein interface [polypeptide binding]; other site 698973000860 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 698973000861 proximal heme binding site [chemical binding]; other site 698973000862 distal heme binding site [chemical binding]; other site 698973000863 putative dimer interface [polypeptide binding]; other site 698973000864 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 698973000865 L-aspartate oxidase; Provisional; Region: PRK06175 698973000866 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 698973000867 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 698973000868 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 698973000869 Predicted membrane protein [Function unknown]; Region: COG2733 698973000870 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 698973000871 Class I aldolases; Region: Aldolase_Class_I; cd00945 698973000872 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698973000873 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 698973000874 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698973000875 FeS/SAM binding site; other site 698973000876 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 698973000877 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698973000878 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 698973000879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698973000880 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 698973000881 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 698973000882 FAD binding domain; Region: FAD_binding_4; pfam01565 698973000883 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 698973000884 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698973000885 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698973000886 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698973000887 acyl-activating enzyme (AAE) consensus motif; other site 698973000888 AMP binding site [chemical binding]; other site 698973000889 active site 698973000890 CoA binding site [chemical binding]; other site 698973000891 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698973000892 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698973000893 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698973000894 acyl-activating enzyme (AAE) consensus motif; other site 698973000895 AMP binding site [chemical binding]; other site 698973000896 active site 698973000897 CoA binding site [chemical binding]; other site 698973000898 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 698973000899 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 698973000900 putative ADP-binding pocket [chemical binding]; other site 698973000901 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698973000902 catalytic core [active] 698973000903 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698973000904 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698973000905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698973000906 dimer interface [polypeptide binding]; other site 698973000907 phosphorylation site [posttranslational modification] 698973000908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698973000909 ATP binding site [chemical binding]; other site 698973000910 Mg2+ binding site [ion binding]; other site 698973000911 G-X-G motif; other site 698973000912 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698973000913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698973000914 active site 698973000915 phosphorylation site [posttranslational modification] 698973000916 intermolecular recognition site; other site 698973000917 dimerization interface [polypeptide binding]; other site 698973000918 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698973000919 DNA binding site [nucleotide binding] 698973000920 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 698973000921 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 698973000922 DNA binding domain, excisionase family; Region: excise; TIGR01764 698973000923 Thioredoxin; Region: Thioredoxin_4; cl17273 698973000924 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698973000925 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698973000926 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 698973000927 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698973000928 motif II; other site 698973000929 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 698973000930 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 698973000931 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 698973000932 tRNA; other site 698973000933 putative tRNA binding site [nucleotide binding]; other site 698973000934 putative NADP binding site [chemical binding]; other site 698973000935 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 698973000936 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 698973000937 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 698973000938 domain interfaces; other site 698973000939 active site 698973000940 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 698973000941 active site 698973000942 homodimer interface [polypeptide binding]; other site 698973000943 SAM binding site [chemical binding]; other site 698973000944 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 698973000945 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 698973000946 active site 698973000947 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 698973000948 dimer interface [polypeptide binding]; other site 698973000949 active site 698973000950 Schiff base residues; other site 698973000951 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 698973000952 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698973000953 Predicted membrane protein [Function unknown]; Region: COG2311 698973000954 Protein of unknown function (DUF418); Region: DUF418; pfam04235 698973000955 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 698973000956 substrate binding site [chemical binding]; other site 698973000957 active site 698973000958 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 698973000959 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 698973000960 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698973000961 inhibitor-cofactor binding pocket; inhibition site 698973000962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698973000963 catalytic residue [active] 698973000964 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698973000965 catalytic core [active] 698973000966 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698973000967 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698973000968 catalytic residues [active] 698973000969 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698973000970 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698973000971 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 698973000972 ResB-like family; Region: ResB; pfam05140 698973000973 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 698973000974 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698973000975 dimerization interface [polypeptide binding]; other site 698973000976 putative DNA binding site [nucleotide binding]; other site 698973000977 putative Zn2+ binding site [ion binding]; other site 698973000978 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 698973000979 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 698973000980 UbiA prenyltransferase family; Region: UbiA; pfam01040 698973000981 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698973000982 active site 698973000983 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698973000984 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 698973000985 acyl-activating enzyme (AAE) consensus motif; other site 698973000986 AMP binding site [chemical binding]; other site 698973000987 active site 698973000988 CoA binding site [chemical binding]; other site 698973000989 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 698973000990 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698973000991 substrate binding site [chemical binding]; other site 698973000992 oxyanion hole (OAH) forming residues; other site 698973000993 trimer interface [polypeptide binding]; other site 698973000994 O-succinylbenzoate synthase; Provisional; Region: PRK02901 698973000995 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 698973000996 active site 698973000997 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 698973000998 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 698973000999 dimer interface [polypeptide binding]; other site 698973001000 tetramer interface [polypeptide binding]; other site 698973001001 PYR/PP interface [polypeptide binding]; other site 698973001002 TPP binding site [chemical binding]; other site 698973001003 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 698973001004 TPP-binding site; other site 698973001005 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698973001006 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 698973001007 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 698973001008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698973001009 S-adenosylmethionine binding site [chemical binding]; other site 698973001010 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 698973001011 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 698973001012 NAD binding site [chemical binding]; other site 698973001013 dimer interface [polypeptide binding]; other site 698973001014 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698973001015 substrate binding site [chemical binding]; other site 698973001016 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 698973001017 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698973001018 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698973001019 substrate binding pocket [chemical binding]; other site 698973001020 chain length determination region; other site 698973001021 substrate-Mg2+ binding site; other site 698973001022 catalytic residues [active] 698973001023 aspartate-rich region 1; other site 698973001024 active site lid residues [active] 698973001025 aspartate-rich region 2; other site 698973001026 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 698973001027 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 698973001028 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 698973001029 putative homodimer interface [polypeptide binding]; other site 698973001030 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 698973001031 heterodimer interface [polypeptide binding]; other site 698973001032 homodimer interface [polypeptide binding]; other site 698973001033 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 698973001034 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 698973001035 23S rRNA interface [nucleotide binding]; other site 698973001036 L7/L12 interface [polypeptide binding]; other site 698973001037 putative thiostrepton binding site; other site 698973001038 L25 interface [polypeptide binding]; other site 698973001039 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 698973001040 mRNA/rRNA interface [nucleotide binding]; other site 698973001041 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 698973001042 23S rRNA interface [nucleotide binding]; other site 698973001043 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 698973001044 50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157 698973001045 L11 interface [polypeptide binding]; other site 698973001046 putative EF-Tu interaction site [polypeptide binding]; other site 698973001047 putative EF-G interaction site [polypeptide binding]; other site 698973001048 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 698973001049 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698973001050 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698973001051 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698973001052 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698973001053 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698973001054 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 698973001055 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698973001056 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698973001057 ABC-ATPase subunit interface; other site 698973001058 dimer interface [polypeptide binding]; other site 698973001059 putative PBP binding regions; other site 698973001060 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698973001061 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698973001062 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698973001063 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698973001064 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 698973001065 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 698973001066 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 698973001067 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 698973001068 RPB1 interaction site [polypeptide binding]; other site 698973001069 RPB10 interaction site [polypeptide binding]; other site 698973001070 RPB11 interaction site [polypeptide binding]; other site 698973001071 RPB3 interaction site [polypeptide binding]; other site 698973001072 RPB12 interaction site [polypeptide binding]; other site 698973001073 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 698973001074 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 698973001075 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 698973001076 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 698973001077 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 698973001078 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698973001079 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 698973001080 G-loop; other site 698973001081 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698973001082 DNA binding site [nucleotide binding] 698973001083 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 698973001084 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698973001085 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698973001086 Walker A/P-loop; other site 698973001087 ATP binding site [chemical binding]; other site 698973001088 Q-loop/lid; other site 698973001089 ABC transporter signature motif; other site 698973001090 Walker B; other site 698973001091 D-loop; other site 698973001092 H-loop/switch region; other site 698973001093 Predicted helicase [General function prediction only]; Region: COG4889 698973001094 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 698973001095 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698973001096 ATP binding site [chemical binding]; other site 698973001097 putative Mg++ binding site [ion binding]; other site 698973001098 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698973001099 nucleotide binding region [chemical binding]; other site 698973001100 ATP-binding site [chemical binding]; other site 698973001101 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 698973001102 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698973001103 Histidine kinase; Region: HisKA_3; pfam07730 698973001104 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698973001105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698973001106 active site 698973001107 phosphorylation site [posttranslational modification] 698973001108 intermolecular recognition site; other site 698973001109 dimerization interface [polypeptide binding]; other site 698973001110 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698973001111 DNA binding residues [nucleotide binding] 698973001112 dimerization interface [polypeptide binding]; other site 698973001113 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698973001114 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698973001115 Walker A/P-loop; other site 698973001116 ATP binding site [chemical binding]; other site 698973001117 Q-loop/lid; other site 698973001118 ABC transporter signature motif; other site 698973001119 Walker B; other site 698973001120 D-loop; other site 698973001121 H-loop/switch region; other site 698973001122 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 698973001123 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 698973001124 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698973001125 TIGR03943 family protein; Region: TIGR03943 698973001126 Predicted permeases [General function prediction only]; Region: COG0701 698973001127 Radical SAM superfamily; Region: Radical_SAM; pfam04055 698973001128 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698973001129 FeS/SAM binding site; other site 698973001130 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 698973001131 Class III ribonucleotide reductase; Region: RNR_III; cd01675 698973001132 effector binding site; other site 698973001133 active site 698973001134 Zn binding site [ion binding]; other site 698973001135 glycine loop; other site 698973001136 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 698973001137 S17 interaction site [polypeptide binding]; other site 698973001138 S8 interaction site; other site 698973001139 16S rRNA interaction site [nucleotide binding]; other site 698973001140 streptomycin interaction site [chemical binding]; other site 698973001141 23S rRNA interaction site [nucleotide binding]; other site 698973001142 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 698973001143 30S ribosomal protein S7; Validated; Region: PRK05302 698973001144 elongation factor G; Reviewed; Region: PRK00007 698973001145 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 698973001146 G1 box; other site 698973001147 putative GEF interaction site [polypeptide binding]; other site 698973001148 GTP/Mg2+ binding site [chemical binding]; other site 698973001149 Switch I region; other site 698973001150 G2 box; other site 698973001151 G3 box; other site 698973001152 Switch II region; other site 698973001153 G4 box; other site 698973001154 G5 box; other site 698973001155 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 698973001156 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 698973001157 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 698973001158 elongation factor Tu; Reviewed; Region: PRK00049 698973001159 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 698973001160 G1 box; other site 698973001161 GEF interaction site [polypeptide binding]; other site 698973001162 GTP/Mg2+ binding site [chemical binding]; other site 698973001163 Switch I region; other site 698973001164 G2 box; other site 698973001165 G3 box; other site 698973001166 Switch II region; other site 698973001167 G4 box; other site 698973001168 G5 box; other site 698973001169 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 698973001170 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 698973001171 Antibiotic Binding Site [chemical binding]; other site 698973001172 Predicted membrane protein [Function unknown]; Region: COG2323 698973001173 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 698973001174 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 698973001175 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 698973001176 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 698973001177 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 698973001178 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 698973001179 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 698973001180 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 698973001181 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 698973001182 putative translocon binding site; other site 698973001183 protein-rRNA interface [nucleotide binding]; other site 698973001184 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 698973001185 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 698973001186 G-X-X-G motif; other site 698973001187 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 698973001188 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 698973001189 23S rRNA interface [nucleotide binding]; other site 698973001190 5S rRNA interface [nucleotide binding]; other site 698973001191 putative antibiotic binding site [chemical binding]; other site 698973001192 L25 interface [polypeptide binding]; other site 698973001193 L27 interface [polypeptide binding]; other site 698973001194 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 698973001195 putative translocon interaction site; other site 698973001196 23S rRNA interface [nucleotide binding]; other site 698973001197 signal recognition particle (SRP54) interaction site; other site 698973001198 L23 interface [polypeptide binding]; other site 698973001199 trigger factor interaction site; other site 698973001200 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 698973001201 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698973001202 HlyD family secretion protein; Region: HlyD_3; pfam13437 698973001203 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698973001204 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698973001205 Walker A/P-loop; other site 698973001206 ATP binding site [chemical binding]; other site 698973001207 Q-loop/lid; other site 698973001208 ABC transporter signature motif; other site 698973001209 Walker B; other site 698973001210 D-loop; other site 698973001211 H-loop/switch region; other site 698973001212 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698973001213 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698973001214 FtsX-like permease family; Region: FtsX; pfam02687 698973001215 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 698973001216 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 698973001217 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 698973001218 RNA binding site [nucleotide binding]; other site 698973001219 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 698973001220 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 698973001221 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 698973001222 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 698973001223 serine transporter; Region: stp; TIGR00814 698973001224 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698973001225 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698973001226 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698973001227 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698973001228 active site 698973001229 homotetramer interface [polypeptide binding]; other site 698973001230 homodimer interface [polypeptide binding]; other site 698973001231 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 698973001232 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698973001233 ATP binding site [chemical binding]; other site 698973001234 substrate interface [chemical binding]; other site 698973001235 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698973001236 active site residue [active] 698973001237 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698973001238 MPT binding site; other site 698973001239 trimer interface [polypeptide binding]; other site 698973001240 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 698973001241 MoaE homodimer interface [polypeptide binding]; other site 698973001242 MoaD interaction [polypeptide binding]; other site 698973001243 active site residues [active] 698973001244 Ubiquitin-like proteins; Region: UBQ; cl00155 698973001245 charged pocket; other site 698973001246 hydrophobic patch; other site 698973001247 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698973001248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698973001249 putative PBP binding loops; other site 698973001250 ABC-ATPase subunit interface; other site 698973001251 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973001252 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698973001253 Walker A/P-loop; other site 698973001254 ATP binding site [chemical binding]; other site 698973001255 Q-loop/lid; other site 698973001256 ABC transporter signature motif; other site 698973001257 Walker B; other site 698973001258 D-loop; other site 698973001259 H-loop/switch region; other site 698973001260 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 698973001261 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 698973001262 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 698973001263 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 698973001264 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 698973001265 [4Fe-4S] binding site [ion binding]; other site 698973001266 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698973001267 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698973001268 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698973001269 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 698973001270 molybdopterin cofactor binding site; other site 698973001271 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 698973001272 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698973001273 MULE transposase domain; Region: MULE; pfam10551 698973001274 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 698973001275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973001276 putative substrate translocation pore; other site 698973001277 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698973001278 MPT binding site; other site 698973001279 trimer interface [polypeptide binding]; other site 698973001280 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 698973001281 GTP binding site; other site 698973001282 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 698973001283 trimer interface [polypeptide binding]; other site 698973001284 dimer interface [polypeptide binding]; other site 698973001285 putative active site [active] 698973001286 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698973001287 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698973001288 dimer interface [polypeptide binding]; other site 698973001289 putative functional site; other site 698973001290 putative MPT binding site; other site 698973001291 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 698973001292 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698973001293 FeS/SAM binding site; other site 698973001294 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 698973001295 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 698973001296 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698973001297 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 698973001298 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 698973001299 Integrase core domain; Region: rve_3; cl15866 698973001300 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 698973001301 hypothetical protein; Reviewed; Region: PRK09588 698973001302 Fic family protein [Function unknown]; Region: COG3177 698973001303 Fic/DOC family; Region: Fic; pfam02661 698973001304 potential frameshift: common BLAST hit: gi|261416833|ref|YP_003250516.1| type II restriction enzyme (methylase subunit) 698973001305 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698973001306 potential frameshift: common BLAST hit: gi|261416833|ref|YP_003250516.1| type II restriction enzyme (methylase subunit) 698973001307 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698973001308 ATP binding site [chemical binding]; other site 698973001309 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698973001310 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698973001311 inhibitor site; inhibition site 698973001312 active site 698973001313 dimer interface [polypeptide binding]; other site 698973001314 catalytic residue [active] 698973001315 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698973001316 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698973001317 Walker A/P-loop; other site 698973001318 ATP binding site [chemical binding]; other site 698973001319 Q-loop/lid; other site 698973001320 ABC transporter signature motif; other site 698973001321 Walker B; other site 698973001322 D-loop; other site 698973001323 H-loop/switch region; other site 698973001324 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698973001325 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698973001326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698973001327 dimer interface [polypeptide binding]; other site 698973001328 conserved gate region; other site 698973001329 putative PBP binding loops; other site 698973001330 ABC-ATPase subunit interface; other site 698973001331 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698973001332 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698973001333 Walker A/P-loop; other site 698973001334 ATP binding site [chemical binding]; other site 698973001335 Q-loop/lid; other site 698973001336 ABC transporter signature motif; other site 698973001337 Walker B; other site 698973001338 D-loop; other site 698973001339 H-loop/switch region; other site 698973001340 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698973001341 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698973001342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698973001343 dimer interface [polypeptide binding]; other site 698973001344 conserved gate region; other site 698973001345 putative PBP binding loops; other site 698973001346 ABC-ATPase subunit interface; other site 698973001347 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 698973001348 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698973001349 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698973001350 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698973001351 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698973001352 DNA-binding site [nucleotide binding]; DNA binding site 698973001353 FCD domain; Region: FCD; pfam07729 698973001354 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698973001355 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698973001356 nucleotide binding site [chemical binding]; other site 698973001357 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 698973001358 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 698973001359 putative active site cavity [active] 698973001360 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 698973001361 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 698973001362 active site 698973001363 dimer interface [polypeptide binding]; other site 698973001364 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698973001365 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 698973001366 active site 698973001367 trimer interface [polypeptide binding]; other site 698973001368 allosteric site; other site 698973001369 active site lid [active] 698973001370 hexamer (dimer of trimers) interface [polypeptide binding]; other site 698973001371 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 698973001372 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 698973001373 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698973001374 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698973001375 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 698973001376 5S rRNA interface [nucleotide binding]; other site 698973001377 L27 interface [polypeptide binding]; other site 698973001378 23S rRNA interface [nucleotide binding]; other site 698973001379 L5 interface [polypeptide binding]; other site 698973001380 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 698973001381 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 698973001382 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 698973001383 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 698973001384 23S rRNA binding site [nucleotide binding]; other site 698973001385 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 698973001386 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 698973001387 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 698973001388 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 698973001389 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698973001390 active site 698973001391 catalytic site [active] 698973001392 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698973001393 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698973001394 active site 698973001395 catalytic site [active] 698973001396 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 698973001397 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698973001398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698973001399 dimer interface [polypeptide binding]; other site 698973001400 conserved gate region; other site 698973001401 putative PBP binding loops; other site 698973001402 ABC-ATPase subunit interface; other site 698973001403 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698973001404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698973001405 dimer interface [polypeptide binding]; other site 698973001406 conserved gate region; other site 698973001407 putative PBP binding loops; other site 698973001408 ABC-ATPase subunit interface; other site 698973001409 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 698973001410 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698973001411 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698973001412 Walker A/P-loop; other site 698973001413 ATP binding site [chemical binding]; other site 698973001414 Q-loop/lid; other site 698973001415 ABC transporter signature motif; other site 698973001416 Walker B; other site 698973001417 D-loop; other site 698973001418 H-loop/switch region; other site 698973001419 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 698973001420 SecY translocase; Region: SecY; pfam00344 698973001421 adenylate kinase; Reviewed; Region: adk; PRK00279 698973001422 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 698973001423 AMP-binding site [chemical binding]; other site 698973001424 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 698973001425 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698973001426 active site 698973001427 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698973001428 catalytic site [active] 698973001429 BNR repeat-like domain; Region: BNR_2; pfam13088 698973001430 Asp-box motif; other site 698973001431 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698973001432 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 698973001433 rRNA binding site [nucleotide binding]; other site 698973001434 predicted 30S ribosome binding site; other site 698973001435 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 698973001436 30S ribosomal protein S13; Region: bact_S13; TIGR03631 698973001437 30S ribosomal protein S11; Validated; Region: PRK05309 698973001438 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 698973001439 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 698973001440 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698973001441 RNA binding surface [nucleotide binding]; other site 698973001442 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 698973001443 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 698973001444 alphaNTD - beta interaction site [polypeptide binding]; other site 698973001445 alphaNTD homodimer interface [polypeptide binding]; other site 698973001446 alphaNTD - beta' interaction site [polypeptide binding]; other site 698973001447 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 698973001448 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 698973001449 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 698973001450 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 698973001451 dimerization interface 3.5A [polypeptide binding]; other site 698973001452 active site 698973001453 Protein of unknown function (DUF690); Region: DUF690; cl04939 698973001454 TIGR02611 family protein; Region: TIGR02611 698973001455 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 698973001456 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 698973001457 active site 698973001458 catalytic residues [active] 698973001459 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 698973001460 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 698973001461 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698973001462 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 698973001463 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698973001464 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698973001465 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 698973001466 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 698973001467 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 698973001468 Integrase core domain; Region: rve; pfam00665 698973001469 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 698973001470 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 698973001471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 698973001472 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 698973001473 23S rRNA interface [nucleotide binding]; other site 698973001474 L3 interface [polypeptide binding]; other site 698973001475 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 698973001476 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 698973001477 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 698973001478 active site 698973001479 substrate binding site [chemical binding]; other site 698973001480 metal binding site [ion binding]; metal-binding site 698973001481 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 698973001482 alanine racemase; Reviewed; Region: alr; PRK00053 698973001483 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 698973001484 active site 698973001485 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698973001486 dimer interface [polypeptide binding]; other site 698973001487 substrate binding site [chemical binding]; other site 698973001488 catalytic residues [active] 698973001489 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 698973001490 Predicted permease [General function prediction only]; Region: COG2985 698973001491 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698973001492 TrkA-C domain; Region: TrkA_C; pfam02080 698973001493 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698973001494 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698973001495 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 698973001496 Glycoprotease family; Region: Peptidase_M22; pfam00814 698973001497 UGMP family protein; Validated; Region: PRK09604 698973001498 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 698973001499 oligomerisation interface [polypeptide binding]; other site 698973001500 mobile loop; other site 698973001501 roof hairpin; other site 698973001502 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698973001503 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698973001504 ring oligomerisation interface [polypeptide binding]; other site 698973001505 ATP/Mg binding site [chemical binding]; other site 698973001506 stacking interactions; other site 698973001507 hinge regions; other site 698973001508 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 698973001509 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698973001510 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698973001511 DNA binding residues [nucleotide binding] 698973001512 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 698973001513 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698973001514 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 698973001515 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 698973001516 active site 698973001517 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 698973001518 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698973001519 phosphate binding site [ion binding]; other site 698973001520 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698973001521 siderophore binding site; other site 698973001522 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698973001523 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698973001524 dimer interface [polypeptide binding]; other site 698973001525 putative PBP binding regions; other site 698973001526 ABC-ATPase subunit interface; other site 698973001527 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698973001528 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698973001529 ABC-ATPase subunit interface; other site 698973001530 dimer interface [polypeptide binding]; other site 698973001531 putative PBP binding regions; other site 698973001532 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698973001533 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698973001534 Walker A/P-loop; other site 698973001535 ATP binding site [chemical binding]; other site 698973001536 Q-loop/lid; other site 698973001537 ABC transporter signature motif; other site 698973001538 Walker B; other site 698973001539 D-loop; other site 698973001540 H-loop/switch region; other site 698973001541 IucA / IucC family; Region: IucA_IucC; pfam04183 698973001542 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698973001543 IucA / IucC family; Region: IucA_IucC; pfam04183 698973001544 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698973001545 H+ Antiporter protein; Region: 2A0121; TIGR00900 698973001546 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 698973001547 EamA-like transporter family; Region: EamA; pfam00892 698973001548 GMP synthase; Reviewed; Region: guaA; PRK00074 698973001549 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 698973001550 AMP/PPi binding site [chemical binding]; other site 698973001551 candidate oxyanion hole; other site 698973001552 catalytic triad [active] 698973001553 potential glutamine specificity residues [chemical binding]; other site 698973001554 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 698973001555 ATP Binding subdomain [chemical binding]; other site 698973001556 Ligand Binding sites [chemical binding]; other site 698973001557 Dimerization subdomain; other site 698973001558 PspC domain; Region: PspC; pfam04024 698973001559 PspC domain; Region: PspC; pfam04024 698973001560 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698973001561 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698973001562 ATP binding site [chemical binding]; other site 698973001563 Mg2+ binding site [ion binding]; other site 698973001564 G-X-G motif; other site 698973001565 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698973001566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698973001567 active site 698973001568 phosphorylation site [posttranslational modification] 698973001569 intermolecular recognition site; other site 698973001570 dimerization interface [polypeptide binding]; other site 698973001571 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698973001572 DNA binding residues [nucleotide binding] 698973001573 dimerization interface [polypeptide binding]; other site 698973001574 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698973001575 intersubunit interface [polypeptide binding]; other site 698973001576 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698973001577 DNA Polymerase Y-family; Region: PolY_like; cd03468 698973001578 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 698973001579 active site 698973001580 DNA binding site [nucleotide binding] 698973001581 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 698973001582 putative dimer interface [polypeptide binding]; other site 698973001583 putative [2Fe-2S] cluster binding site [ion binding]; other site 698973001584 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698973001585 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698973001586 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698973001587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698973001588 dimer interface [polypeptide binding]; other site 698973001589 conserved gate region; other site 698973001590 ABC-ATPase subunit interface; other site 698973001591 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 698973001592 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 698973001593 Walker A/P-loop; other site 698973001594 ATP binding site [chemical binding]; other site 698973001595 Q-loop/lid; other site 698973001596 ABC transporter signature motif; other site 698973001597 Walker B; other site 698973001598 D-loop; other site 698973001599 H-loop/switch region; other site 698973001600 NIL domain; Region: NIL; cl09633 698973001601 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698973001602 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 698973001603 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698973001604 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 698973001605 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 698973001606 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 698973001607 active site 698973001608 PHP Thumb interface [polypeptide binding]; other site 698973001609 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 698973001610 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 698973001611 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 698973001612 Integrase core domain; Region: rve; pfam00665 698973001613 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698973001614 generic binding surface II; other site 698973001615 generic binding surface I; other site 698973001616 Uncharacterized conserved protein [Function unknown]; Region: COG3402 698973001617 Predicted membrane protein [Function unknown]; Region: COG3428 698973001618 Bacterial PH domain; Region: DUF304; pfam03703 698973001619 Bacterial PH domain; Region: DUF304; pfam03703 698973001620 Bacterial PH domain; Region: DUF304; pfam03703 698973001621 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698973001622 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698973001623 intersubunit interface [polypeptide binding]; other site 698973001624 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698973001625 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698973001626 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698973001627 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698973001628 dimer interface [polypeptide binding]; other site 698973001629 putative PBP binding regions; other site 698973001630 ABC-ATPase subunit interface; other site 698973001631 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698973001632 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698973001633 ABC-ATPase subunit interface; other site 698973001634 dimer interface [polypeptide binding]; other site 698973001635 putative PBP binding regions; other site 698973001636 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698973001637 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698973001638 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698973001639 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 698973001640 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 698973001641 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 698973001642 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 698973001643 homodimer interface [polypeptide binding]; other site 698973001644 NADP binding site [chemical binding]; other site 698973001645 substrate binding site [chemical binding]; other site 698973001646 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 698973001647 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698973001648 active site 698973001649 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 698973001650 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 698973001651 potential frameshift: common BLAST hit: gi|337290120|ref|YP_004629141.1| cell-surface hemin receptor 698973001652 Htaa; Region: HtaA; pfam04213 698973001653 Htaa; Region: HtaA; pfam04213 698973001654 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698973001655 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698973001656 intersubunit interface [polypeptide binding]; other site 698973001657 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698973001658 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698973001659 ABC-ATPase subunit interface; other site 698973001660 dimer interface [polypeptide binding]; other site 698973001661 putative PBP binding regions; other site 698973001662 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 698973001663 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698973001664 Walker A/P-loop; other site 698973001665 ATP binding site [chemical binding]; other site 698973001666 Q-loop/lid; other site 698973001667 ABC transporter signature motif; other site 698973001668 Walker B; other site 698973001669 D-loop; other site 698973001670 H-loop/switch region; other site 698973001671 potential frameshift: common BLAST hit: gi|336324789|ref|YP_004604755.1| putative cell-surface hemin receptor 698973001672 Htaa; Region: HtaA; pfam04213 698973001673 Htaa; Region: HtaA; pfam04213 698973001674 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 698973001675 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698973001676 homodimer interface [polypeptide binding]; other site 698973001677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698973001678 substrate-cofactor binding pocket; other site 698973001679 catalytic residue [active] 698973001680 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 698973001681 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 698973001682 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698973001683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973001684 putative substrate translocation pore; other site 698973001685 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698973001686 putative catalytic site [active] 698973001687 putative metal binding site [ion binding]; other site 698973001688 putative phosphate binding site [ion binding]; other site 698973001689 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 698973001690 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 698973001691 active site 698973001692 HIGH motif; other site 698973001693 dimer interface [polypeptide binding]; other site 698973001694 KMSKS motif; other site 698973001695 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 698973001696 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698973001697 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698973001698 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698973001699 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698973001700 NlpC/P60 family; Region: NLPC_P60; pfam00877 698973001701 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698973001702 active site 698973001703 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698973001704 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698973001705 non-specific DNA binding site [nucleotide binding]; other site 698973001706 salt bridge; other site 698973001707 sequence-specific DNA binding site [nucleotide binding]; other site 698973001708 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698973001709 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 698973001710 metal binding site [ion binding]; metal-binding site 698973001711 putative dimer interface [polypeptide binding]; other site 698973001712 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 698973001713 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698973001714 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698973001715 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698973001716 pyruvate carboxylase; Reviewed; Region: PRK12999 698973001717 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698973001718 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698973001719 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698973001720 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698973001721 active site 698973001722 catalytic residues [active] 698973001723 metal binding site [ion binding]; metal-binding site 698973001724 homodimer binding site [polypeptide binding]; other site 698973001725 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698973001726 carboxyltransferase (CT) interaction site; other site 698973001727 biotinylation site [posttranslational modification]; other site 698973001728 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 698973001729 ADP-ribose binding site [chemical binding]; other site 698973001730 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 698973001731 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698973001732 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 698973001733 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698973001734 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698973001735 carboxyltransferase (CT) interaction site; other site 698973001736 biotinylation site [posttranslational modification]; other site 698973001737 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698973001738 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698973001739 active site residue [active] 698973001740 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698973001741 active site residue [active] 698973001742 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698973001743 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 698973001744 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 698973001745 active site 698973001746 dimer interface [polypeptide binding]; other site 698973001747 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 698973001748 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698973001749 substrate binding site [chemical binding]; other site 698973001750 dimer interface [polypeptide binding]; other site 698973001751 ATP binding site [chemical binding]; other site 698973001752 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698973001753 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698973001754 DNA binding site [nucleotide binding] 698973001755 domain linker motif; other site 698973001756 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 698973001757 dimerization interface [polypeptide binding]; other site 698973001758 putative ligand binding site [chemical binding]; other site 698973001759 potential frameshift: common BLAST hit: gi|62391317|ref|YP_226719.1| transposase 698973001760 Transposase; Region: DDE_Tnp_ISL3; pfam01610 698973001761 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 698973001762 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698973001763 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698973001764 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698973001765 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698973001766 MULE transposase domain; Region: MULE; pfam10551 698973001767 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698973001768 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698973001769 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698973001770 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 698973001771 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 698973001772 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 698973001773 ATP-grasp domain; Region: ATP-grasp; pfam02222 698973001774 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 698973001775 Uncharacterized conserved protein [Function unknown]; Region: COG1434 698973001776 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698973001777 putative active site [active] 698973001778 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 698973001779 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 698973001780 HupF/HypC family; Region: HupF_HypC; pfam01455 698973001781 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 698973001782 dimerization interface [polypeptide binding]; other site 698973001783 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 698973001784 ATP binding site [chemical binding]; other site 698973001785 Acylphosphatase; Region: Acylphosphatase; pfam00708 698973001786 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 698973001787 HypF finger; Region: zf-HYPF; pfam07503 698973001788 HypF finger; Region: zf-HYPF; pfam07503 698973001789 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 698973001790 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 698973001791 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698973001792 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 698973001793 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 698973001794 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 698973001795 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 698973001796 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 698973001797 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 698973001798 putative substrate-binding site; other site 698973001799 nickel binding site [ion binding]; other site 698973001800 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 698973001801 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 698973001802 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 698973001803 HupF/HypC family; Region: HupF_HypC; cl00394 698973001804 TIGR03089 family protein; Region: TIGR03089 698973001805 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698973001806 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698973001807 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698973001808 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698973001809 active site 698973001810 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698973001811 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 698973001812 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 698973001813 active site 698973001814 Substrate binding site; other site 698973001815 Mg++ binding site; other site 698973001816 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698973001817 putative trimer interface [polypeptide binding]; other site 698973001818 putative CoA binding site [chemical binding]; other site 698973001819 Transcription factor WhiB; Region: Whib; pfam02467 698973001820 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 698973001821 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 698973001822 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 698973001823 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 698973001824 active site 698973001825 substrate binding site [chemical binding]; other site 698973001826 metal binding site [ion binding]; metal-binding site 698973001827 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 698973001828 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698973001829 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698973001830 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 698973001831 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 698973001832 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 698973001833 homotetramer interface [polypeptide binding]; other site 698973001834 ligand binding site [chemical binding]; other site 698973001835 catalytic site [active] 698973001836 NAD binding site [chemical binding]; other site 698973001837 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 698973001838 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 698973001839 TMP-binding site; other site 698973001840 ATP-binding site [chemical binding]; other site 698973001841 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698973001842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698973001843 active site 698973001844 phosphorylation site [posttranslational modification] 698973001845 intermolecular recognition site; other site 698973001846 dimerization interface [polypeptide binding]; other site 698973001847 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698973001848 DNA binding site [nucleotide binding] 698973001849 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698973001850 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698973001851 dimerization interface [polypeptide binding]; other site 698973001852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698973001853 dimer interface [polypeptide binding]; other site 698973001854 phosphorylation site [posttranslational modification] 698973001855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698973001856 ATP binding site [chemical binding]; other site 698973001857 Mg2+ binding site [ion binding]; other site 698973001858 G-X-G motif; other site 698973001859 lipoprotein LpqB; Provisional; Region: PRK13616 698973001860 Sporulation and spore germination; Region: Germane; pfam10646 698973001861 comF family protein; Region: comF; TIGR00201 698973001862 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698973001863 active site 698973001864 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 698973001865 30S subunit binding site; other site 698973001866 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 698973001867 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698973001868 ATP binding site [chemical binding]; other site 698973001869 putative Mg++ binding site [ion binding]; other site 698973001870 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 698973001871 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698973001872 nucleotide binding region [chemical binding]; other site 698973001873 ATP-binding site [chemical binding]; other site 698973001874 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 698973001875 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 698973001876 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698973001877 FAD binding pocket [chemical binding]; other site 698973001878 FAD binding motif [chemical binding]; other site 698973001879 phosphate binding motif [ion binding]; other site 698973001880 beta-alpha-beta structure motif; other site 698973001881 NAD binding pocket [chemical binding]; other site 698973001882 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698973001883 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 698973001884 catalytic loop [active] 698973001885 iron binding site [ion binding]; other site 698973001886 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 698973001887 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 698973001888 putative di-iron ligands [ion binding]; other site 698973001889 Predicted GTPases [General function prediction only]; Region: COG1162 698973001890 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 698973001891 GTPase/Zn-binding domain interface [polypeptide binding]; other site 698973001892 GTP/Mg2+ binding site [chemical binding]; other site 698973001893 G4 box; other site 698973001894 G5 box; other site 698973001895 G1 box; other site 698973001896 Switch I region; other site 698973001897 G2 box; other site 698973001898 G3 box; other site 698973001899 Switch II region; other site 698973001900 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 698973001901 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 698973001902 hinge; other site 698973001903 active site 698973001904 Uncharacterized conserved protein [Function unknown]; Region: COG2135 698973001905 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 698973001906 putative deacylase active site [active] 698973001907 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 698973001908 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698973001909 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698973001910 DNA binding residues [nucleotide binding] 698973001911 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 698973001912 Transcription factor WhiB; Region: Whib; pfam02467 698973001913 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698973001914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698973001915 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698973001916 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698973001917 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698973001918 non-specific DNA binding site [nucleotide binding]; other site 698973001919 salt bridge; other site 698973001920 sequence-specific DNA binding site [nucleotide binding]; other site 698973001921 PQQ-like domain; Region: PQQ_2; pfam13360 698973001922 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698973001923 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698973001924 ATP binding site [chemical binding]; other site 698973001925 putative Mg++ binding site [ion binding]; other site 698973001926 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698973001927 nucleotide binding region [chemical binding]; other site 698973001928 ATP-binding site [chemical binding]; other site 698973001929 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 698973001930 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 698973001931 TIGR02569 family protein; Region: TIGR02569_actnb 698973001932 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698973001933 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698973001934 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698973001935 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698973001936 Part of AAA domain; Region: AAA_19; pfam13245 698973001937 Family description; Region: UvrD_C_2; pfam13538 698973001938 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698973001939 Ion channel; Region: Ion_trans_2; pfam07885 698973001940 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 698973001941 TrkA-N domain; Region: TrkA_N; pfam02254 698973001942 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 698973001943 putative NADH binding site [chemical binding]; other site 698973001944 putative active site [active] 698973001945 nudix motif; other site 698973001946 putative metal binding site [ion binding]; other site 698973001947 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 698973001948 Part of AAA domain; Region: AAA_19; pfam13245 698973001949 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698973001950 Family description; Region: UvrD_C_2; pfam13538 698973001951 HRDC domain; Region: HRDC; pfam00570 698973001952 Protein of unknown function DUF45; Region: DUF45; cl00636 698973001953 putative hydrolase; Region: TIGR03624 698973001954 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 698973001955 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698973001956 hypothetical protein; Validated; Region: PRK00068 698973001957 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 698973001958 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698973001959 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698973001960 HTH-like domain; Region: HTH_21; pfam13276 698973001961 Integrase core domain; Region: rve; pfam00665 698973001962 Integrase core domain; Region: rve_2; pfam13333 698973001963 potential frameshift: common BLAST hit: gi|172040624|ref|YP_001800338.1| transposase for insertion sequence 698973001964 Helix-turn-helix domain; Region: HTH_38; pfam13936 698973001965 Integrase core domain; Region: rve; pfam00665 698973001966 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698973001967 Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731 698973001968 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698973001969 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 698973001970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973001971 Walker A/P-loop; other site 698973001972 ATP binding site [chemical binding]; other site 698973001973 Q-loop/lid; other site 698973001974 ABC transporter signature motif; other site 698973001975 Walker B; other site 698973001976 D-loop; other site 698973001977 H-loop/switch region; other site 698973001978 Abi-like protein; Region: Abi_2; pfam07751 698973001979 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 698973001980 FIC domain binding interface [polypeptide binding]; other site 698973001981 Fic/DOC family; Region: Fic; cl00960 698973001982 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698973001983 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698973001984 P-loop; other site 698973001985 Magnesium ion binding site [ion binding]; other site 698973001986 Winged helix-turn helix; Region: HTH_29; pfam13551 698973001987 Helix-turn-helix domain; Region: HTH_28; pfam13518 698973001988 putative transposase OrfB; Reviewed; Region: PHA02517 698973001989 HTH-like domain; Region: HTH_21; pfam13276 698973001990 Integrase core domain; Region: rve; pfam00665 698973001991 Integrase core domain; Region: rve_2; pfam13333 698973001992 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698973001993 Integrase core domain; Region: rve; pfam00665 698973001994 Integrase core domain; Region: rve_2; pfam13333 698973001995 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698973001996 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 698973001997 active site 698973001998 oxaloacetate decarboxylase; Provisional; Region: PRK12330 698973001999 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698973002000 active site 698973002001 catalytic residues [active] 698973002002 metal binding site [ion binding]; metal-binding site 698973002003 homodimer binding site [polypeptide binding]; other site 698973002004 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 698973002005 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698973002006 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698973002007 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698973002008 carboxyltransferase (CT) interaction site; other site 698973002009 biotinylation site [posttranslational modification]; other site 698973002010 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698973002011 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 698973002012 active site 698973002013 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698973002014 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698973002015 active site 698973002016 peptide chain release factor 2; Validated; Region: prfB; PRK00578 698973002017 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698973002018 RF-1 domain; Region: RF-1; pfam00472 698973002019 AbgT putative transporter family; Region: ABG_transport; cl17431 698973002020 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698973002021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698973002022 HTH-like domain; Region: HTH_21; pfam13276 698973002023 Integrase core domain; Region: rve; pfam00665 698973002024 Integrase core domain; Region: rve_2; pfam13333 698973002025 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 698973002026 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698973002027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973002028 Walker A/P-loop; other site 698973002029 ATP binding site [chemical binding]; other site 698973002030 Q-loop/lid; other site 698973002031 ABC transporter signature motif; other site 698973002032 Walker B; other site 698973002033 D-loop; other site 698973002034 H-loop/switch region; other site 698973002035 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 698973002036 FtsX-like permease family; Region: FtsX; pfam02687 698973002037 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 698973002038 SmpB-tmRNA interface; other site 698973002039 Cupin domain; Region: Cupin_2; cl17218 698973002040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698973002041 S-adenosylmethionine binding site [chemical binding]; other site 698973002042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698973002043 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698973002044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698973002045 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 698973002046 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698973002047 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698973002048 putative Mg++ binding site [ion binding]; other site 698973002049 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698973002050 nucleotide binding region [chemical binding]; other site 698973002051 ATP-binding site [chemical binding]; other site 698973002052 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698973002053 Helix-turn-helix domain; Region: HTH_38; pfam13936 698973002054 Integrase core domain; Region: rve; pfam00665 698973002055 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698973002056 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698973002057 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698973002058 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 698973002059 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698973002060 DNA-binding site [nucleotide binding]; DNA binding site 698973002061 RNA-binding motif; other site 698973002062 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 698973002063 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 698973002064 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 698973002065 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 698973002066 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698973002067 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698973002068 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 698973002069 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698973002070 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698973002071 catalytic residue [active] 698973002072 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 698973002073 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 698973002074 dimer interface [polypeptide binding]; other site 698973002075 active site 698973002076 citrylCoA binding site [chemical binding]; other site 698973002077 NADH binding [chemical binding]; other site 698973002078 cationic pore residues; other site 698973002079 oxalacetate/citrate binding site [chemical binding]; other site 698973002080 coenzyme A binding site [chemical binding]; other site 698973002081 catalytic triad [active] 698973002082 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698973002083 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 698973002084 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698973002085 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698973002086 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698973002087 active site 698973002088 catalytic tetrad [active] 698973002089 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 698973002090 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698973002091 substrate binding site [chemical binding]; other site 698973002092 oxyanion hole (OAH) forming residues; other site 698973002093 trimer interface [polypeptide binding]; other site 698973002094 Protein of unknown function, DUF485; Region: DUF485; pfam04341 698973002095 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698973002096 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 698973002097 Na binding site [ion binding]; other site 698973002098 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 698973002099 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 698973002100 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698973002101 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 698973002102 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 698973002103 active site 698973002104 SAM binding site [chemical binding]; other site 698973002105 homodimer interface [polypeptide binding]; other site 698973002106 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698973002107 catalytic residues [active] 698973002108 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 698973002109 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 698973002110 folate binding site [chemical binding]; other site 698973002111 NADP+ binding site [chemical binding]; other site 698973002112 thymidylate synthase; Reviewed; Region: thyA; PRK01827 698973002113 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 698973002114 dimerization interface [polypeptide binding]; other site 698973002115 active site 698973002116 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 698973002117 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698973002118 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 698973002119 ATP binding site [chemical binding]; other site 698973002120 putative Mg++ binding site [ion binding]; other site 698973002121 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698973002122 nucleotide binding region [chemical binding]; other site 698973002123 ATP-binding site [chemical binding]; other site 698973002124 DEAD/H associated; Region: DEAD_assoc; pfam08494 698973002125 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 698973002126 active site 698973002127 SUMO-1 interface [polypeptide binding]; other site 698973002128 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698973002129 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 698973002130 putative DNA binding site [nucleotide binding]; other site 698973002131 catalytic residue [active] 698973002132 putative H2TH interface [polypeptide binding]; other site 698973002133 putative catalytic residues [active] 698973002134 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698973002135 Predicted permease [General function prediction only]; Region: COG2985 698973002136 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698973002137 TrkA-C domain; Region: TrkA_C; pfam02080 698973002138 TrkA-C domain; Region: TrkA_C; pfam02080 698973002139 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698973002140 hypothetical protein; Provisional; Region: PRK11770 698973002141 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698973002142 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698973002143 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 698973002144 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 698973002145 active site 698973002146 dimer interface [polypeptide binding]; other site 698973002147 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 698973002148 dimer interface [polypeptide binding]; other site 698973002149 active site 698973002150 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698973002151 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698973002152 tetramerization interface [polypeptide binding]; other site 698973002153 NAD(P) binding site [chemical binding]; other site 698973002154 catalytic residues [active] 698973002155 hypothetical protein; Provisional; Region: PRK07857 698973002156 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 698973002157 Part of AAA domain; Region: AAA_19; pfam13245 698973002158 Family description; Region: UvrD_C_2; pfam13538 698973002159 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698973002160 Peptidase family M23; Region: Peptidase_M23; pfam01551 698973002161 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 698973002162 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 698973002163 active site 698973002164 substrate binding site [chemical binding]; other site 698973002165 cosubstrate binding site; other site 698973002166 catalytic site [active] 698973002167 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 698973002168 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 698973002169 purine monophosphate binding site [chemical binding]; other site 698973002170 dimer interface [polypeptide binding]; other site 698973002171 putative catalytic residues [active] 698973002172 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 698973002173 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698973002174 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698973002175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698973002176 HTH-like domain; Region: HTH_21; pfam13276 698973002177 Integrase core domain; Region: rve; pfam00665 698973002178 Integrase core domain; Region: rve_2; pfam13333 698973002179 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 698973002180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698973002181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698973002182 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 698973002183 30S ribosomal protein S18; Provisional; Region: PRK13401 698973002184 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 698973002185 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 698973002186 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 698973002187 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 698973002188 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 698973002189 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698973002190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698973002191 active site 698973002192 phosphorylation site [posttranslational modification] 698973002193 intermolecular recognition site; other site 698973002194 dimerization interface [polypeptide binding]; other site 698973002195 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698973002196 DNA binding site [nucleotide binding] 698973002197 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698973002198 dimerization interface [polypeptide binding]; other site 698973002199 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698973002200 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698973002201 dimer interface [polypeptide binding]; other site 698973002202 phosphorylation site [posttranslational modification] 698973002203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698973002204 ATP binding site [chemical binding]; other site 698973002205 Mg2+ binding site [ion binding]; other site 698973002206 G-X-G motif; other site 698973002207 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698973002208 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698973002209 protein binding site [polypeptide binding]; other site 698973002210 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698973002211 MPT binding site; other site 698973002212 trimer interface [polypeptide binding]; other site 698973002213 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 698973002214 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 698973002215 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 698973002216 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 698973002217 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 698973002218 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 698973002219 active site 698973002220 tetramer interface; other site 698973002221 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698973002222 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698973002223 dimer interface [polypeptide binding]; other site 698973002224 putative functional site; other site 698973002225 putative MPT binding site; other site 698973002226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698973002227 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698973002228 Predicted membrane protein [Function unknown]; Region: COG2259 698973002229 Predicted integral membrane protein [Function unknown]; Region: COG5660 698973002230 Putative zinc-finger; Region: zf-HC2; pfam13490 698973002231 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 698973002232 BCCT family transporter; Region: BCCT; pfam02028 698973002233 Uncharacterized membrane protein [Function unknown]; Region: COG3949 698973002234 Predicted methyltransferases [General function prediction only]; Region: COG0313 698973002235 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 698973002236 putative SAM binding site [chemical binding]; other site 698973002237 putative homodimer interface [polypeptide binding]; other site 698973002238 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 698973002239 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 698973002240 active site 698973002241 HIGH motif; other site 698973002242 KMSKS motif; other site 698973002243 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 698973002244 tRNA binding surface [nucleotide binding]; other site 698973002245 anticodon binding site; other site 698973002246 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 698973002247 active site 698973002248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 698973002249 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698973002250 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698973002251 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698973002252 G5 domain; Region: G5; pfam07501 698973002253 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698973002254 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 698973002255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698973002256 S-adenosylmethionine binding site [chemical binding]; other site 698973002257 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 698973002258 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698973002259 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698973002260 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698973002261 ABC transporter; Region: ABC_tran_2; pfam12848 698973002262 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698973002263 Uncharacterized conserved protein [Function unknown]; Region: COG1359 698973002264 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698973002265 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698973002266 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698973002267 DNA binding residues [nucleotide binding] 698973002268 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698973002269 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 698973002270 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698973002271 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698973002272 active site 698973002273 motif I; other site 698973002274 motif II; other site 698973002275 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698973002276 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 698973002277 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698973002278 substrate binding site [chemical binding]; other site 698973002279 oxyanion hole (OAH) forming residues; other site 698973002280 trimer interface [polypeptide binding]; other site 698973002281 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 698973002282 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698973002283 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698973002284 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 698973002285 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 698973002286 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698973002287 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 698973002288 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 698973002289 G1 box; other site 698973002290 putative GEF interaction site [polypeptide binding]; other site 698973002291 GTP/Mg2+ binding site [chemical binding]; other site 698973002292 Switch I region; other site 698973002293 G2 box; other site 698973002294 G3 box; other site 698973002295 Switch II region; other site 698973002296 G4 box; other site 698973002297 G5 box; other site 698973002298 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 698973002299 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698973002300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698973002301 NAD(P) binding site [chemical binding]; other site 698973002302 active site 698973002303 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698973002304 putative active site [active] 698973002305 catalytic residue [active] 698973002306 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698973002307 active site 698973002308 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698973002309 putative active site [active] 698973002310 catalytic residue [active] 698973002311 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 698973002312 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 698973002313 5S rRNA interface [nucleotide binding]; other site 698973002314 CTC domain interface [polypeptide binding]; other site 698973002315 L16 interface [polypeptide binding]; other site 698973002316 pullulanase, type I; Region: pulA_typeI; TIGR02104 698973002317 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 698973002318 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 698973002319 Ca binding site [ion binding]; other site 698973002320 active site 698973002321 catalytic site [active] 698973002322 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 698973002323 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 698973002324 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698973002325 active site 698973002326 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 698973002327 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 698973002328 Substrate binding site; other site 698973002329 Mg++ binding site; other site 698973002330 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 698973002331 active site 698973002332 substrate binding site [chemical binding]; other site 698973002333 CoA binding site [chemical binding]; other site 698973002334 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698973002335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698973002336 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 698973002337 putative dimerization interface [polypeptide binding]; other site 698973002338 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 698973002339 gating phenylalanine in ion channel; other site 698973002340 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698973002341 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 698973002342 putative ligand binding site [chemical binding]; other site 698973002343 putative NAD binding site [chemical binding]; other site 698973002344 catalytic site [active] 698973002345 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698973002346 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698973002347 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973002348 Q-loop/lid; other site 698973002349 ABC transporter signature motif; other site 698973002350 Walker B; other site 698973002351 D-loop; other site 698973002352 H-loop/switch region; other site 698973002353 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698973002354 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698973002355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973002356 Walker A/P-loop; other site 698973002357 ATP binding site [chemical binding]; other site 698973002358 Q-loop/lid; other site 698973002359 ABC transporter signature motif; other site 698973002360 Walker B; other site 698973002361 D-loop; other site 698973002362 H-loop/switch region; other site 698973002363 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698973002364 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698973002365 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 698973002366 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 698973002367 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698973002368 ATP binding site [chemical binding]; other site 698973002369 putative Mg++ binding site [ion binding]; other site 698973002370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698973002371 nucleotide binding region [chemical binding]; other site 698973002372 ATP-binding site [chemical binding]; other site 698973002373 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 698973002374 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 698973002375 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 698973002376 homodimer interface [polypeptide binding]; other site 698973002377 metal binding site [ion binding]; metal-binding site 698973002378 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 698973002379 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698973002380 enolase; Provisional; Region: eno; PRK00077 698973002381 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 698973002382 dimer interface [polypeptide binding]; other site 698973002383 metal binding site [ion binding]; metal-binding site 698973002384 substrate binding pocket [chemical binding]; other site 698973002385 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 698973002386 Septum formation initiator; Region: DivIC; pfam04977 698973002387 Uncharacterized conserved protein [Function unknown]; Region: COG1507 698973002388 exopolyphosphatase; Region: exo_poly_only; TIGR03706 698973002389 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698973002390 Helix-turn-helix domain; Region: HTH_18; pfam12833 698973002391 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698973002392 Bax inhibitor 1 like; Region: BaxI_1; cl17691 698973002393 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 698973002394 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 698973002395 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 698973002396 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 698973002397 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 698973002398 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 698973002399 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698973002400 catalytic residue [active] 698973002401 putative FPP diphosphate binding site; other site 698973002402 putative FPP binding hydrophobic cleft; other site 698973002403 dimer interface [polypeptide binding]; other site 698973002404 putative IPP diphosphate binding site; other site 698973002405 Flavodoxin domain; Region: Flavodoxin_5; cl17428 698973002406 pantothenate kinase; Provisional; Region: PRK05439 698973002407 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 698973002408 ATP-binding site [chemical binding]; other site 698973002409 CoA-binding site [chemical binding]; other site 698973002410 Mg2+-binding site [ion binding]; other site 698973002411 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 698973002412 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 698973002413 dimer interface [polypeptide binding]; other site 698973002414 active site 698973002415 glycine-pyridoxal phosphate binding site [chemical binding]; other site 698973002416 folate binding site [chemical binding]; other site 698973002417 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698973002418 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 698973002419 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698973002420 Coenzyme A binding pocket [chemical binding]; other site 698973002421 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698973002422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973002423 putative substrate translocation pore; other site 698973002424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973002425 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698973002426 fumarate hydratase; Reviewed; Region: fumC; PRK00485 698973002427 Class II fumarases; Region: Fumarase_classII; cd01362 698973002428 active site 698973002429 tetramer interface [polypeptide binding]; other site 698973002430 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 698973002431 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 698973002432 putative active site [active] 698973002433 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 698973002434 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 698973002435 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 698973002436 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 698973002437 generic binding surface II; other site 698973002438 generic binding surface I; other site 698973002439 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 698973002440 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 698973002441 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698973002442 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698973002443 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 698973002444 Na2 binding site [ion binding]; other site 698973002445 putative substrate binding site 1 [chemical binding]; other site 698973002446 Na binding site 1 [ion binding]; other site 698973002447 putative substrate binding site 2 [chemical binding]; other site 698973002448 GTP-binding protein YchF; Reviewed; Region: PRK09601 698973002449 YchF GTPase; Region: YchF; cd01900 698973002450 G1 box; other site 698973002451 GTP/Mg2+ binding site [chemical binding]; other site 698973002452 Switch I region; other site 698973002453 G2 box; other site 698973002454 Switch II region; other site 698973002455 G3 box; other site 698973002456 G4 box; other site 698973002457 G5 box; other site 698973002458 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 698973002459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 698973002460 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 698973002461 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 698973002462 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 698973002463 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 698973002464 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 698973002465 Cl- selectivity filter; other site 698973002466 Cl- binding residues [ion binding]; other site 698973002467 pore gating glutamate residue; other site 698973002468 dimer interface [polypeptide binding]; other site 698973002469 Homeodomain-like domain; Region: HTH_23; cl17451 698973002470 Helix-turn-helix domain; Region: HTH_28; pfam13518 698973002471 putative transposase OrfB; Reviewed; Region: PHA02517 698973002472 HTH-like domain; Region: HTH_21; pfam13276 698973002473 Integrase core domain; Region: rve; pfam00665 698973002474 Integrase core domain; Region: rve_2; pfam13333 698973002475 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698973002476 Walker A/P-loop; other site 698973002477 ATP binding site [chemical binding]; other site 698973002478 ABC transporter; Region: ABC_tran; pfam00005 698973002479 Q-loop/lid; other site 698973002480 ABC transporter signature motif; other site 698973002481 Walker B; other site 698973002482 D-loop; other site 698973002483 H-loop/switch region; other site 698973002484 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 698973002485 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698973002486 Walker A/P-loop; other site 698973002487 ATP binding site [chemical binding]; other site 698973002488 Q-loop/lid; other site 698973002489 ABC transporter signature motif; other site 698973002490 Walker B; other site 698973002491 D-loop; other site 698973002492 H-loop/switch region; other site 698973002493 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698973002494 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 698973002495 active site 698973002496 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698973002497 Integrase core domain; Region: rve; pfam00665 698973002498 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698973002499 dihydropteroate synthase; Region: DHPS; TIGR01496 698973002500 substrate binding pocket [chemical binding]; other site 698973002501 dimer interface [polypeptide binding]; other site 698973002502 inhibitor binding site; inhibition site 698973002503 Homeodomain-like domain; Region: HTH_23; cl17451 698973002504 Integrase core domain; Region: rve; pfam00665 698973002505 Integrase core domain; Region: rve_3; pfam13683 698973002506 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 698973002507 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 698973002508 G1 box; other site 698973002509 putative GEF interaction site [polypeptide binding]; other site 698973002510 GTP/Mg2+ binding site [chemical binding]; other site 698973002511 Switch I region; other site 698973002512 G2 box; other site 698973002513 G3 box; other site 698973002514 Switch II region; other site 698973002515 G4 box; other site 698973002516 G5 box; other site 698973002517 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 698973002518 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 698973002519 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 698973002520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973002521 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698973002522 putative substrate translocation pore; other site 698973002523 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 698973002524 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 698973002525 Integrase core domain; Region: rve; pfam00665 698973002526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 698973002527 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 698973002528 active site 698973002529 metal binding site [ion binding]; metal-binding site 698973002530 interdomain interaction site; other site 698973002531 multiple promoter invertase; Provisional; Region: mpi; PRK13413 698973002532 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698973002533 catalytic residues [active] 698973002534 catalytic nucleophile [active] 698973002535 Presynaptic Site I dimer interface [polypeptide binding]; other site 698973002536 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698973002537 Synaptic Flat tetramer interface [polypeptide binding]; other site 698973002538 Synaptic Site I dimer interface [polypeptide binding]; other site 698973002539 DNA binding site [nucleotide binding] 698973002540 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 698973002541 DNA-binding interface [nucleotide binding]; DNA binding site 698973002542 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698973002543 active site 698973002544 catalytic site [active] 698973002545 substrate binding site [chemical binding]; other site 698973002546 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 698973002547 Int/Topo IB signature motif; other site 698973002548 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698973002549 Integrase core domain; Region: rve; pfam00665 698973002550 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698973002551 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698973002552 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698973002553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698973002554 dimer interface [polypeptide binding]; other site 698973002555 conserved gate region; other site 698973002556 ABC-ATPase subunit interface; other site 698973002557 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698973002558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698973002559 dimer interface [polypeptide binding]; other site 698973002560 conserved gate region; other site 698973002561 putative PBP binding loops; other site 698973002562 ABC-ATPase subunit interface; other site 698973002563 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698973002564 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698973002565 Walker A/P-loop; other site 698973002566 ATP binding site [chemical binding]; other site 698973002567 Q-loop/lid; other site 698973002568 ABC transporter signature motif; other site 698973002569 Walker B; other site 698973002570 D-loop; other site 698973002571 H-loop/switch region; other site 698973002572 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698973002573 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698973002574 Walker A/P-loop; other site 698973002575 ATP binding site [chemical binding]; other site 698973002576 Q-loop/lid; other site 698973002577 ABC transporter signature motif; other site 698973002578 Walker B; other site 698973002579 D-loop; other site 698973002580 H-loop/switch region; other site 698973002581 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698973002582 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698973002583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973002584 Walker A/P-loop; other site 698973002585 ATP binding site [chemical binding]; other site 698973002586 ABC transporter signature motif; other site 698973002587 Walker B; other site 698973002588 D-loop; other site 698973002589 H-loop/switch region; other site 698973002590 potential frameshift: common BLAST hit: gi|336118205|ref|YP_004572974.1| transposase orfB for insertion sequence element 698973002591 potential frameshift: common BLAST hit: gi|269958070|ref|YP_003327859.1| Integrase catalytic region 698973002592 Integrase core domain; Region: rve; pfam00665 698973002593 Integrase core domain; Region: rve_3; pfam13683 698973002594 Trypsin; Region: Trypsin; pfam00089 698973002595 active site 698973002596 substrate binding sites [chemical binding]; other site 698973002597 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 698973002598 ArsC family; Region: ArsC; pfam03960 698973002599 catalytic residues [active] 698973002600 Protein of unknown function (DUF402); Region: DUF402; cl00979 698973002601 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 698973002602 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 698973002603 G1 box; other site 698973002604 GTP/Mg2+ binding site [chemical binding]; other site 698973002605 G2 box; other site 698973002606 Switch I region; other site 698973002607 G3 box; other site 698973002608 Switch II region; other site 698973002609 G4 box; other site 698973002610 G5 box; other site 698973002611 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 698973002612 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 698973002613 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 698973002614 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698973002615 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 698973002616 Ferredoxin [Energy production and conversion]; Region: COG1146 698973002617 4Fe-4S binding domain; Region: Fer4; pfam00037 698973002618 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 698973002619 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698973002620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698973002621 homodimer interface [polypeptide binding]; other site 698973002622 catalytic residue [active] 698973002623 potential frameshift: common BLAST hit: gi|38233570|ref|NP_939337.1| RNA pseudouridylate synthase 698973002624 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698973002625 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698973002626 Predicted membrane protein [Function unknown]; Region: COG2246 698973002627 GtrA-like protein; Region: GtrA; pfam04138 698973002628 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698973002629 active site 698973002630 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 698973002631 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698973002632 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 698973002633 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 698973002634 putative trimer interface [polypeptide binding]; other site 698973002635 putative CoA binding site [chemical binding]; other site 698973002636 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 698973002637 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698973002638 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 698973002639 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698973002640 putative trimer interface [polypeptide binding]; other site 698973002641 putative CoA binding site [chemical binding]; other site 698973002642 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 698973002643 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 698973002644 metal binding site [ion binding]; metal-binding site 698973002645 putative dimer interface [polypeptide binding]; other site 698973002646 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698973002647 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698973002648 dihydropteroate synthase; Region: DHPS; TIGR01496 698973002649 substrate binding pocket [chemical binding]; other site 698973002650 dimer interface [polypeptide binding]; other site 698973002651 inhibitor binding site; inhibition site 698973002652 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 698973002653 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 698973002654 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 698973002655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698973002656 S-adenosylmethionine binding site [chemical binding]; other site 698973002657 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 698973002658 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 698973002659 active site 698973002660 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 698973002661 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 698973002662 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 698973002663 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698973002664 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 698973002665 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 698973002666 ligand binding site; other site 698973002667 oligomer interface; other site 698973002668 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 698973002669 dimer interface [polypeptide binding]; other site 698973002670 N-terminal domain interface [polypeptide binding]; other site 698973002671 sulfate 1 binding site; other site 698973002672 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 698973002673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698973002674 Putative zinc-finger; Region: zf-HC2; pfam13490 698973002675 sec-independent translocase; Provisional; Region: tatB; PRK00182 698973002676 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 698973002677 Domain of unknown function DUF59; Region: DUF59; pfam01883 698973002678 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 698973002679 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 698973002680 Predicted membrane protein [Function unknown]; Region: COG4420 698973002681 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 698973002682 MgtE intracellular N domain; Region: MgtE_N; smart00924 698973002683 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 698973002684 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 698973002685 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698973002686 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 698973002687 TPP-binding site [chemical binding]; other site 698973002688 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 698973002689 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698973002690 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698973002691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973002692 Walker A/P-loop; other site 698973002693 ATP binding site [chemical binding]; other site 698973002694 Q-loop/lid; other site 698973002695 ABC transporter signature motif; other site 698973002696 Walker B; other site 698973002697 D-loop; other site 698973002698 H-loop/switch region; other site 698973002699 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698973002700 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698973002701 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973002702 Walker A/P-loop; other site 698973002703 ATP binding site [chemical binding]; other site 698973002704 Q-loop/lid; other site 698973002705 ABC transporter signature motif; other site 698973002706 Walker B; other site 698973002707 D-loop; other site 698973002708 H-loop/switch region; other site 698973002709 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 698973002710 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698973002711 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698973002712 shikimate binding site; other site 698973002713 NAD(P) binding site [chemical binding]; other site 698973002714 potential frameshift: common BLAST hit: gi|38233602|ref|NP_939369.1| type B carboxylesterase 698973002715 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698973002716 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698973002717 substrate binding pocket [chemical binding]; other site 698973002718 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698973002719 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698973002720 catalytic triad [active] 698973002721 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 698973002722 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 698973002723 active site 698973002724 catalytic residues [active] 698973002725 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 698973002726 putative transporter; Provisional; Region: PRK10484 698973002727 Na binding site [ion binding]; other site 698973002728 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698973002729 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 698973002730 nucleotide binding site/active site [active] 698973002731 HIT family signature motif; other site 698973002732 catalytic residue [active] 698973002733 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 698973002734 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698973002735 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698973002736 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698973002737 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698973002738 non-specific DNA binding site [nucleotide binding]; other site 698973002739 salt bridge; other site 698973002740 sequence-specific DNA binding site [nucleotide binding]; other site 698973002741 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 698973002742 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 698973002743 cofactor binding site; other site 698973002744 DNA binding site [nucleotide binding] 698973002745 substrate interaction site [chemical binding]; other site 698973002746 EcoRII C terminal; Region: EcoRII-C; pfam09019 698973002747 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 698973002748 Z1 domain; Region: Z1; pfam10593 698973002749 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 698973002750 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698973002751 ATP binding site [chemical binding]; other site 698973002752 Mg++ binding site [ion binding]; other site 698973002753 motif III; other site 698973002754 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698973002755 nucleotide binding region [chemical binding]; other site 698973002756 ATP-binding site [chemical binding]; other site 698973002757 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 698973002758 putative RNA binding site [nucleotide binding]; other site 698973002759 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698973002760 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698973002761 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 698973002762 Na binding site [ion binding]; other site 698973002763 SNF2 Helicase protein; Region: DUF3670; pfam12419 698973002764 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 698973002765 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698973002766 ATP binding site [chemical binding]; other site 698973002767 putative Mg++ binding site [ion binding]; other site 698973002768 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698973002769 nucleotide binding region [chemical binding]; other site 698973002770 ATP-binding site [chemical binding]; other site 698973002771 Uncharacterized conserved protein [Function unknown]; Region: COG4279 698973002772 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 698973002773 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 698973002774 active site 698973002775 metal binding site [ion binding]; metal-binding site 698973002776 DNA binding site [nucleotide binding] 698973002777 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 698973002778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973002779 Walker A/P-loop; other site 698973002780 ATP binding site [chemical binding]; other site 698973002781 Q-loop/lid; other site 698973002782 Uncharacterized conserved protein [Function unknown]; Region: COG2353 698973002783 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698973002784 MarR family; Region: MarR_2; pfam12802 698973002785 PspC domain; Region: PspC; cl00864 698973002786 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698973002787 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 698973002788 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698973002789 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 698973002790 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698973002791 Cysteine-rich domain; Region: CCG; pfam02754 698973002792 Cysteine-rich domain; Region: CCG; pfam02754 698973002793 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698973002794 L-lactate permease; Region: Lactate_perm; cl00701 698973002795 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 698973002796 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 698973002797 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 698973002798 active site 698973002799 HIGH motif; other site 698973002800 KMSK motif region; other site 698973002801 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 698973002802 tRNA binding surface [nucleotide binding]; other site 698973002803 anticodon binding site; other site 698973002804 diaminopimelate decarboxylase; Region: lysA; TIGR01048 698973002805 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 698973002806 active site 698973002807 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698973002808 substrate binding site [chemical binding]; other site 698973002809 catalytic residues [active] 698973002810 dimer interface [polypeptide binding]; other site 698973002811 homoserine dehydrogenase; Provisional; Region: PRK06349 698973002812 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 698973002813 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 698973002814 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 698973002815 homoserine kinase; Provisional; Region: PRK01212 698973002816 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 698973002817 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698973002818 acyl-activating enzyme (AAE) consensus motif; other site 698973002819 AMP binding site [chemical binding]; other site 698973002820 active site 698973002821 CoA binding site [chemical binding]; other site 698973002822 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 698973002823 transcription termination factor Rho; Provisional; Region: PRK12608 698973002824 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698973002825 RNA binding site [nucleotide binding]; other site 698973002826 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 698973002827 multimer interface [polypeptide binding]; other site 698973002828 Walker A motif; other site 698973002829 ATP binding site [chemical binding]; other site 698973002830 Walker B motif; other site 698973002831 peptide chain release factor 1; Validated; Region: prfA; PRK00591 698973002832 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698973002833 RF-1 domain; Region: RF-1; pfam00472 698973002834 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 698973002835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698973002836 S-adenosylmethionine binding site [chemical binding]; other site 698973002837 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 698973002838 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 698973002839 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 698973002840 Mg++ binding site [ion binding]; other site 698973002841 putative catalytic motif [active] 698973002842 substrate binding site [chemical binding]; other site 698973002843 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 698973002844 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 698973002845 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 698973002846 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 698973002847 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 698973002848 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 698973002849 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 698973002850 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 698973002851 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698973002852 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 698973002853 beta subunit interaction interface [polypeptide binding]; other site 698973002854 Walker A motif; other site 698973002855 ATP binding site [chemical binding]; other site 698973002856 Walker B motif; other site 698973002857 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698973002858 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 698973002859 core domain interface [polypeptide binding]; other site 698973002860 delta subunit interface [polypeptide binding]; other site 698973002861 epsilon subunit interface [polypeptide binding]; other site 698973002862 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 698973002863 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698973002864 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 698973002865 alpha subunit interaction interface [polypeptide binding]; other site 698973002866 Walker A motif; other site 698973002867 ATP binding site [chemical binding]; other site 698973002868 Walker B motif; other site 698973002869 inhibitor binding site; inhibition site 698973002870 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698973002871 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 698973002872 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 698973002873 gamma subunit interface [polypeptide binding]; other site 698973002874 epsilon subunit interface [polypeptide binding]; other site 698973002875 LBP interface [polypeptide binding]; other site 698973002876 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 698973002877 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 698973002878 hypothetical protein; Provisional; Region: PRK03298 698973002879 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 698973002880 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698973002881 dimer interface [polypeptide binding]; other site 698973002882 substrate binding site [chemical binding]; other site 698973002883 metal binding site [ion binding]; metal-binding site 698973002884 Domain of unknown function DUF77; Region: DUF77; pfam01910 698973002885 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698973002886 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698973002887 Walker A/P-loop; other site 698973002888 ATP binding site [chemical binding]; other site 698973002889 Q-loop/lid; other site 698973002890 ABC transporter signature motif; other site 698973002891 Walker B; other site 698973002892 D-loop; other site 698973002893 H-loop/switch region; other site 698973002894 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698973002895 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698973002896 ABC-ATPase subunit interface; other site 698973002897 dimer interface [polypeptide binding]; other site 698973002898 putative PBP binding regions; other site 698973002899 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698973002900 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698973002901 ABC-ATPase subunit interface; other site 698973002902 dimer interface [polypeptide binding]; other site 698973002903 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698973002904 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698973002905 siderophore binding site; other site 698973002906 TIGR02611 family protein; Region: TIGR02611 698973002907 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 698973002908 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 698973002909 glycogen branching enzyme; Provisional; Region: PRK05402 698973002910 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 698973002911 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 698973002912 active site 698973002913 catalytic site [active] 698973002914 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 698973002915 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 698973002916 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 698973002917 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698973002918 active site 698973002919 homodimer interface [polypeptide binding]; other site 698973002920 catalytic site [active] 698973002921 acceptor binding site [chemical binding]; other site 698973002922 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698973002923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973002924 Walker A/P-loop; other site 698973002925 ATP binding site [chemical binding]; other site 698973002926 Q-loop/lid; other site 698973002927 ABC transporter signature motif; other site 698973002928 Walker B; other site 698973002929 D-loop; other site 698973002930 H-loop/switch region; other site 698973002931 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 698973002932 Ligand binding site [chemical binding]; other site 698973002933 Electron transfer flavoprotein domain; Region: ETF; pfam01012 698973002934 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 698973002935 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 698973002936 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 698973002937 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 698973002938 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 698973002939 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698973002940 catalytic residue [active] 698973002941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698973002942 S-adenosylmethionine binding site [chemical binding]; other site 698973002943 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 698973002944 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 698973002945 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698973002946 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698973002947 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698973002948 active site 698973002949 catalytic site [active] 698973002950 substrate binding site [chemical binding]; other site 698973002951 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 698973002952 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 698973002953 nucleotide binding pocket [chemical binding]; other site 698973002954 K-X-D-G motif; other site 698973002955 catalytic site [active] 698973002956 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 698973002957 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 698973002958 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 698973002959 Dimer interface [polypeptide binding]; other site 698973002960 BRCT sequence motif; other site 698973002961 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698973002962 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 698973002963 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698973002964 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 698973002965 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 698973002966 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698973002967 Coenzyme A binding pocket [chemical binding]; other site 698973002968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973002969 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698973002970 putative substrate translocation pore; other site 698973002971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973002972 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698973002973 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698973002974 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698973002975 ABC-ATPase subunit interface; other site 698973002976 dimer interface [polypeptide binding]; other site 698973002977 putative PBP binding regions; other site 698973002978 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698973002979 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973002980 Walker A/P-loop; other site 698973002981 ATP binding site [chemical binding]; other site 698973002982 Q-loop/lid; other site 698973002983 ABC transporter signature motif; other site 698973002984 Walker B; other site 698973002985 D-loop; other site 698973002986 H-loop/switch region; other site 698973002987 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 698973002988 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 698973002989 putative ligand binding residues [chemical binding]; other site 698973002990 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 698973002991 phosphofructokinase; Region: PFK_mixed; TIGR02483 698973002992 active site 698973002993 ADP/pyrophosphate binding site [chemical binding]; other site 698973002994 dimerization interface [polypeptide binding]; other site 698973002995 allosteric effector site; other site 698973002996 fructose-1,6-bisphosphate binding site; other site 698973002997 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 698973002998 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 698973002999 GatB domain; Region: GatB_Yqey; smart00845 698973003000 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698973003001 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698973003002 active site 698973003003 catalytic tetrad [active] 698973003004 Lysine efflux permease [General function prediction only]; Region: COG1279 698973003005 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 698973003006 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698973003007 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698973003008 dimerization interface [polypeptide binding]; other site 698973003009 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 698973003010 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 698973003011 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 698973003012 putative dimer interface [polypeptide binding]; other site 698973003013 N-terminal domain interface [polypeptide binding]; other site 698973003014 putative substrate binding pocket (H-site) [chemical binding]; other site 698973003015 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698973003016 Predicted membrane protein [Function unknown]; Region: COG2259 698973003017 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 698973003018 potential frameshift: common BLAST hit: gi|38233691|ref|NP_939458.1| low molecular weight protein antigen 6 698973003019 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698973003020 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 698973003021 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698973003022 PYR/PP interface [polypeptide binding]; other site 698973003023 dimer interface [polypeptide binding]; other site 698973003024 TPP binding site [chemical binding]; other site 698973003025 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698973003026 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 698973003027 TPP-binding site [chemical binding]; other site 698973003028 dimer interface [polypeptide binding]; other site 698973003029 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 698973003030 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 698973003031 putative valine binding site [chemical binding]; other site 698973003032 dimer interface [polypeptide binding]; other site 698973003033 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 698973003034 ketol-acid reductoisomerase; Provisional; Region: PRK05479 698973003035 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 698973003036 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 698973003037 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 698973003038 Uncharacterized conserved protein [Function unknown]; Region: COG1479 698973003039 Protein of unknown function DUF262; Region: DUF262; pfam03235 698973003040 Uncharacterized conserved protein [Function unknown]; Region: COG3472 698973003041 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 698973003042 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 698973003043 ligand binding site [chemical binding]; other site 698973003044 NAD binding site [chemical binding]; other site 698973003045 dimerization interface [polypeptide binding]; other site 698973003046 catalytic site [active] 698973003047 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 698973003048 putative L-serine binding site [chemical binding]; other site 698973003049 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 698973003050 tartrate dehydrogenase; Region: TTC; TIGR02089 698973003051 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698973003052 ligand binding site [chemical binding]; other site 698973003053 flexible hinge region; other site 698973003054 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698973003055 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698973003056 metal binding triad; other site 698973003057 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 698973003058 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 698973003059 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698973003060 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698973003061 catalytic site [active] 698973003062 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 698973003063 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 698973003064 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 698973003065 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698973003066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698973003067 S-adenosylmethionine binding site [chemical binding]; other site 698973003068 isochorismate synthase DhbC; Validated; Region: PRK06923 698973003069 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698973003070 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 698973003071 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698973003072 active site 698973003073 HIGH motif; other site 698973003074 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698973003075 active site 698973003076 KMSKS motif; other site 698973003077 Predicted esterase [General function prediction only]; Region: COG0400 698973003078 MMPL family; Region: MMPL; pfam03176 698973003079 Ethanolamine utilisation protein, EutH; Region: EutH; cl01248 698973003080 Cutinase; Region: Cutinase; pfam01083 698973003081 Homeodomain-like domain; Region: HTH_23; cl17451 698973003082 Helix-turn-helix domain; Region: HTH_28; pfam13518 698973003083 putative transposase OrfB; Reviewed; Region: PHA02517 698973003084 HTH-like domain; Region: HTH_21; pfam13276 698973003085 Integrase core domain; Region: rve; pfam00665 698973003086 Integrase core domain; Region: rve_2; pfam13333 698973003087 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 698973003088 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 698973003089 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 698973003090 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 698973003091 PhnA protein; Region: PhnA; pfam03831 698973003092 biotin synthase; Region: bioB; TIGR00433 698973003093 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698973003094 FeS/SAM binding site; other site 698973003095 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698973003096 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698973003097 HD domain; Region: HD_4; pfam13328 698973003098 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698973003099 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698973003100 putative DNA binding site [nucleotide binding]; other site 698973003101 putative Zn2+ binding site [ion binding]; other site 698973003102 Bacterial transcriptional regulator; Region: IclR; pfam01614 698973003103 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 698973003104 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 698973003105 substrate binding site [chemical binding]; other site 698973003106 ligand binding site [chemical binding]; other site 698973003107 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 698973003108 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 698973003109 substrate binding site [chemical binding]; other site 698973003110 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698973003111 active site 698973003112 Ap6A binding site [chemical binding]; other site 698973003113 nudix motif; other site 698973003114 metal binding site [ion binding]; metal-binding site 698973003115 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698973003116 catalytic core [active] 698973003117 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 698973003118 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698973003119 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 698973003120 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 698973003121 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 698973003122 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698973003123 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698973003124 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698973003125 thiamine monophosphate kinase; Provisional; Region: PRK05731 698973003126 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 698973003127 ATP binding site [chemical binding]; other site 698973003128 dimerization interface [polypeptide binding]; other site 698973003129 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 698973003130 ligand binding site [chemical binding]; other site 698973003131 active site 698973003132 UGI interface [polypeptide binding]; other site 698973003133 catalytic site [active] 698973003134 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 698973003135 DAK2 domain; Region: Dak2; pfam02734 698973003136 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 698973003137 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 698973003138 generic binding surface II; other site 698973003139 ssDNA binding site; other site 698973003140 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698973003141 ATP binding site [chemical binding]; other site 698973003142 putative Mg++ binding site [ion binding]; other site 698973003143 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698973003144 nucleotide binding region [chemical binding]; other site 698973003145 ATP-binding site [chemical binding]; other site 698973003146 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 698973003147 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698973003148 carboxyltransferase (CT) interaction site; other site 698973003149 biotinylation site [posttranslational modification]; other site 698973003150 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 698973003151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698973003152 S-adenosylmethionine binding site [chemical binding]; other site 698973003153 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 698973003154 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 698973003155 active site 698973003156 (T/H)XGH motif; other site 698973003157 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698973003158 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698973003159 Walker A/P-loop; other site 698973003160 ATP binding site [chemical binding]; other site 698973003161 Q-loop/lid; other site 698973003162 ABC transporter signature motif; other site 698973003163 Walker B; other site 698973003164 D-loop; other site 698973003165 H-loop/switch region; other site 698973003166 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698973003167 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698973003168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698973003169 dimer interface [polypeptide binding]; other site 698973003170 conserved gate region; other site 698973003171 putative PBP binding loops; other site 698973003172 ABC-ATPase subunit interface; other site 698973003173 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698973003174 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698973003175 substrate binding pocket [chemical binding]; other site 698973003176 membrane-bound complex binding site; other site 698973003177 hinge residues; other site 698973003178 Domain of unknown function (DUF368); Region: DUF368; pfam04018 698973003179 DNA polymerase I; Provisional; Region: PRK05755 698973003180 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 698973003181 active site 698973003182 metal binding site 1 [ion binding]; metal-binding site 698973003183 putative 5' ssDNA interaction site; other site 698973003184 metal binding site 3; metal-binding site 698973003185 metal binding site 2 [ion binding]; metal-binding site 698973003186 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 698973003187 putative DNA binding site [nucleotide binding]; other site 698973003188 putative metal binding site [ion binding]; other site 698973003189 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 698973003190 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 698973003191 active site 698973003192 DNA binding site [nucleotide binding] 698973003193 catalytic site [active] 698973003194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698973003195 S-adenosylmethionine binding site [chemical binding]; other site 698973003196 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 698973003197 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 698973003198 RNA binding site [nucleotide binding]; other site 698973003199 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 698973003200 RNA binding site [nucleotide binding]; other site 698973003201 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698973003202 RNA binding site [nucleotide binding]; other site 698973003203 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 698973003204 RNA binding site [nucleotide binding]; other site 698973003205 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 698973003206 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 698973003207 transcriptional antiterminator BglG; Provisional; Region: PRK09772 698973003208 CAT RNA binding domain; Region: CAT_RBD; smart01061 698973003209 PRD domain; Region: PRD; pfam00874 698973003210 PRD domain; Region: PRD; pfam00874 698973003211 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 698973003212 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698973003213 active site turn [active] 698973003214 phosphorylation site [posttranslational modification] 698973003215 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698973003216 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 698973003217 HPr interaction site; other site 698973003218 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698973003219 active site 698973003220 phosphorylation site [posttranslational modification] 698973003221 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 698973003222 CoA-binding site [chemical binding]; other site 698973003223 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 698973003224 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698973003225 FeS/SAM binding site; other site 698973003226 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 698973003227 excinuclease ABC subunit B; Provisional; Region: PRK05298 698973003228 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698973003229 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698973003230 nucleotide binding region [chemical binding]; other site 698973003231 ATP-binding site [chemical binding]; other site 698973003232 Ultra-violet resistance protein B; Region: UvrB; pfam12344 698973003233 UvrB/uvrC motif; Region: UVR; pfam02151 698973003234 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698973003235 Ligand Binding Site [chemical binding]; other site 698973003236 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 698973003237 Part of AAA domain; Region: AAA_19; pfam13245 698973003238 PhoH-like protein; Region: PhoH; cl17668 698973003239 Family description; Region: UvrD_C_2; pfam13538 698973003240 Predicted membrane protein [Function unknown]; Region: COG2259 698973003241 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698973003242 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 698973003243 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698973003244 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698973003245 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 698973003246 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 698973003247 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 698973003248 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 698973003249 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 698973003250 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 698973003251 23S rRNA binding site [nucleotide binding]; other site 698973003252 L21 binding site [polypeptide binding]; other site 698973003253 L13 binding site [polypeptide binding]; other site 698973003254 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698973003255 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 698973003256 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698973003257 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 698973003258 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 698973003259 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 698973003260 dimer interface [polypeptide binding]; other site 698973003261 motif 1; other site 698973003262 active site 698973003263 motif 2; other site 698973003264 motif 3; other site 698973003265 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 698973003266 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 698973003267 putative tRNA-binding site [nucleotide binding]; other site 698973003268 B3/4 domain; Region: B3_4; pfam03483 698973003269 tRNA synthetase B5 domain; Region: B5; smart00874 698973003270 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 698973003271 dimer interface [polypeptide binding]; other site 698973003272 motif 1; other site 698973003273 motif 3; other site 698973003274 motif 2; other site 698973003275 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 698973003276 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 698973003277 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698973003278 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 698973003279 heterotetramer interface [polypeptide binding]; other site 698973003280 active site pocket [active] 698973003281 cleavage site 698973003282 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 698973003283 feedback inhibition sensing region; other site 698973003284 homohexameric interface [polypeptide binding]; other site 698973003285 nucleotide binding site [chemical binding]; other site 698973003286 N-acetyl-L-glutamate binding site [chemical binding]; other site 698973003287 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 698973003288 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698973003289 inhibitor-cofactor binding pocket; inhibition site 698973003290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698973003291 catalytic residue [active] 698973003292 ornithine carbamoyltransferase; Provisional; Region: PRK00779 698973003293 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698973003294 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698973003295 arginine repressor; Provisional; Region: PRK03341 698973003296 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 698973003297 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 698973003298 argininosuccinate synthase; Provisional; Region: PRK13820 698973003299 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 698973003300 ANP binding site [chemical binding]; other site 698973003301 Substrate Binding Site II [chemical binding]; other site 698973003302 Substrate Binding Site I [chemical binding]; other site 698973003303 argininosuccinate lyase; Provisional; Region: PRK00855 698973003304 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 698973003305 active sites [active] 698973003306 tetramer interface [polypeptide binding]; other site 698973003307 Uncharacterized conserved protein [Function unknown]; Region: COG2835 698973003308 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 698973003309 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 698973003310 active site 698973003311 HIGH motif; other site 698973003312 dimer interface [polypeptide binding]; other site 698973003313 KMSKS motif; other site 698973003314 S4 RNA-binding domain; Region: S4; smart00363 698973003315 RNA binding surface [nucleotide binding]; other site 698973003316 transcription termination factor Rho; Provisional; Region: PRK12678 698973003317 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698973003318 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698973003319 active site 698973003320 motif I; other site 698973003321 motif II; other site 698973003322 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698973003323 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 698973003324 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698973003325 RNA binding surface [nucleotide binding]; other site 698973003326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698973003327 S-adenosylmethionine binding site [chemical binding]; other site 698973003328 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 698973003329 ATP-NAD kinase; Region: NAD_kinase; pfam01513 698973003330 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 698973003331 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698973003332 Walker A/P-loop; other site 698973003333 ATP binding site [chemical binding]; other site 698973003334 Q-loop/lid; other site 698973003335 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698973003336 ABC transporter signature motif; other site 698973003337 Walker B; other site 698973003338 D-loop; other site 698973003339 H-loop/switch region; other site 698973003340 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 698973003341 Thiamine pyrophosphokinase; Region: TPK; cl08415 698973003342 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 698973003343 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 698973003344 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 698973003345 dimer interface [polypeptide binding]; other site 698973003346 ADP-ribose binding site [chemical binding]; other site 698973003347 active site 698973003348 nudix motif; other site 698973003349 metal binding site [ion binding]; metal-binding site 698973003350 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 698973003351 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 698973003352 active site 698973003353 Int/Topo IB signature motif; other site 698973003354 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698973003355 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698973003356 P-loop; other site 698973003357 Magnesium ion binding site [ion binding]; other site 698973003358 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698973003359 Magnesium ion binding site [ion binding]; other site 698973003360 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 698973003361 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698973003362 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 698973003363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973003364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973003365 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 698973003366 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698973003367 inhibitor-cofactor binding pocket; inhibition site 698973003368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698973003369 catalytic residue [active] 698973003370 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698973003371 AAA domain; Region: AAA_26; pfam13500 698973003372 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 698973003373 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 698973003374 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698973003375 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698973003376 RNA binding surface [nucleotide binding]; other site 698973003377 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 698973003378 active site 698973003379 cytidylate kinase; Provisional; Region: cmk; PRK00023 698973003380 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 698973003381 CMP-binding site; other site 698973003382 The sites determining sugar specificity; other site 698973003383 GTP-binding protein Der; Reviewed; Region: PRK03003 698973003384 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 698973003385 G1 box; other site 698973003386 GTP/Mg2+ binding site [chemical binding]; other site 698973003387 Switch I region; other site 698973003388 G2 box; other site 698973003389 Switch II region; other site 698973003390 G3 box; other site 698973003391 G4 box; other site 698973003392 G5 box; other site 698973003393 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 698973003394 G1 box; other site 698973003395 GTP/Mg2+ binding site [chemical binding]; other site 698973003396 Switch I region; other site 698973003397 G2 box; other site 698973003398 G3 box; other site 698973003399 Switch II region; other site 698973003400 G4 box; other site 698973003401 G5 box; other site 698973003402 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698973003403 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 698973003404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698973003405 S-adenosylmethionine binding site [chemical binding]; other site 698973003406 Putative esterase; Region: Esterase; pfam00756 698973003407 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698973003408 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 698973003409 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698973003410 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 698973003411 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698973003412 nucleotide binding region [chemical binding]; other site 698973003413 ATP-binding site [chemical binding]; other site 698973003414 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698973003415 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698973003416 phosphopeptide binding site; other site 698973003417 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 698973003418 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698973003419 DNA binding residues [nucleotide binding] 698973003420 Bifunctional nuclease; Region: DNase-RNase; pfam02577 698973003421 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 698973003422 DNA binding residues [nucleotide binding] 698973003423 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698973003424 putative dimer interface [polypeptide binding]; other site 698973003425 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698973003426 metal ion-dependent adhesion site (MIDAS); other site 698973003427 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698973003428 Domain of unknown function DUF21; Region: DUF21; pfam01595 698973003429 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698973003430 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698973003431 Domain of unknown function DUF21; Region: DUF21; pfam01595 698973003432 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698973003433 Transporter associated domain; Region: CorC_HlyC; smart01091 698973003434 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 698973003435 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698973003436 ATP binding site [chemical binding]; other site 698973003437 Mg++ binding site [ion binding]; other site 698973003438 motif III; other site 698973003439 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698973003440 nucleotide binding region [chemical binding]; other site 698973003441 ATP-binding site [chemical binding]; other site 698973003442 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698973003443 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 698973003444 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 698973003445 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 698973003446 CoenzymeA binding site [chemical binding]; other site 698973003447 subunit interaction site [polypeptide binding]; other site 698973003448 PHB binding site; other site 698973003449 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 698973003450 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 698973003451 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 698973003452 oligomer interface [polypeptide binding]; other site 698973003453 metal binding site [ion binding]; metal-binding site 698973003454 metal binding site [ion binding]; metal-binding site 698973003455 putative Cl binding site [ion binding]; other site 698973003456 basic sphincter; other site 698973003457 hydrophobic gate; other site 698973003458 periplasmic entrance; other site 698973003459 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698973003460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698973003461 S-adenosylmethionine binding site [chemical binding]; other site 698973003462 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698973003463 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698973003464 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698973003465 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 698973003466 potential frameshift: common BLAST hit: gi|38233809|ref|NP_939576.1| sodium-dependent transport membrane protein 698973003467 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698973003468 Sodium Bile acid symporter family; Region: SBF; pfam01758 698973003469 bile acid transporter; Region: bass; TIGR00841 698973003470 YceI-like domain; Region: YceI; pfam04264 698973003471 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 698973003472 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 698973003473 Ligand binding site; other site 698973003474 Putative Catalytic site; other site 698973003475 DXD motif; other site 698973003476 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 698973003477 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 698973003478 putative active site [active] 698973003479 catalytic triad [active] 698973003480 putative dimer interface [polypeptide binding]; other site 698973003481 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 698973003482 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 698973003483 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698973003484 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698973003485 precorrin-3B synthase; Region: CobG; TIGR02435 698973003486 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698973003487 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698973003488 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 698973003489 Precorrin-8X methylmutase; Region: CbiC; pfam02570 698973003490 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 698973003491 active site 698973003492 SAM binding site [chemical binding]; other site 698973003493 homodimer interface [polypeptide binding]; other site 698973003494 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 698973003495 active site 698973003496 SAM binding site [chemical binding]; other site 698973003497 homodimer interface [polypeptide binding]; other site 698973003498 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 698973003499 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 698973003500 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 698973003501 active site 698973003502 SAM binding site [chemical binding]; other site 698973003503 homodimer interface [polypeptide binding]; other site 698973003504 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 698973003505 active site 698973003506 putative homodimer interface [polypeptide binding]; other site 698973003507 SAM binding site [chemical binding]; other site 698973003508 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 698973003509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698973003510 S-adenosylmethionine binding site [chemical binding]; other site 698973003511 hypothetical protein; Provisional; Region: PRK05599 698973003512 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698973003513 NAD(P) binding site [chemical binding]; other site 698973003514 active site 698973003515 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698973003516 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698973003517 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698973003518 active site 698973003519 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698973003520 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698973003521 ATP binding site [chemical binding]; other site 698973003522 putative Mg++ binding site [ion binding]; other site 698973003523 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698973003524 nucleotide binding region [chemical binding]; other site 698973003525 ATP-binding site [chemical binding]; other site 698973003526 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 698973003527 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 698973003528 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 698973003529 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 698973003530 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 698973003531 Predicted transcriptional regulator [Transcription]; Region: COG2378 698973003532 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 698973003533 WYL domain; Region: WYL; pfam13280 698973003534 WYL domain; Region: WYL; pfam13280 698973003535 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 698973003536 Pup-like protein; Region: Pup; pfam05639 698973003537 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 698973003538 proteasome ATPase; Region: pup_AAA; TIGR03689 698973003539 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698973003540 Walker A motif; other site 698973003541 ATP binding site [chemical binding]; other site 698973003542 Walker B motif; other site 698973003543 arginine finger; other site 698973003544 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 698973003545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698973003546 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 698973003547 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 698973003548 active site 698973003549 metal binding site [ion binding]; metal-binding site 698973003550 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 698973003551 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 698973003552 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 698973003553 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 698973003554 Potassium binding sites [ion binding]; other site 698973003555 Cesium cation binding sites [ion binding]; other site 698973003556 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 698973003557 Aspartase; Region: Aspartase; cd01357 698973003558 active sites [active] 698973003559 tetramer interface [polypeptide binding]; other site 698973003560 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698973003561 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 698973003562 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 698973003563 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 698973003564 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 698973003565 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 698973003566 homodimer interface [polypeptide binding]; other site 698973003567 putative metal binding site [ion binding]; other site 698973003568 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 698973003569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698973003570 motif II; other site 698973003571 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 698973003572 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 698973003573 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 698973003574 substrate binding pocket [chemical binding]; other site 698973003575 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 698973003576 B12 binding site [chemical binding]; other site 698973003577 cobalt ligand [ion binding]; other site 698973003578 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 698973003579 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 698973003580 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698973003581 active site 698973003582 HIGH motif; other site 698973003583 nucleotide binding site [chemical binding]; other site 698973003584 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698973003585 active site 698973003586 KMSKS motif; other site 698973003587 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698973003588 tRNA binding surface [nucleotide binding]; other site 698973003589 anticodon binding site; other site 698973003590 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 698973003591 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 698973003592 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 698973003593 quinone interaction residues [chemical binding]; other site 698973003594 active site 698973003595 catalytic residues [active] 698973003596 FMN binding site [chemical binding]; other site 698973003597 substrate binding site [chemical binding]; other site 698973003598 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 698973003599 substrate binding site [chemical binding]; other site 698973003600 potential frameshift: common BLAST hit: gi|38233440|ref|NP_939207.1| transposase 698973003601 Integrase core domain; Region: rve_2; pfam13333 698973003602 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698973003603 HTH-like domain; Region: HTH_21; pfam13276 698973003604 Integrase core domain; Region: rve; pfam00665 698973003605 potential frameshift: common BLAST hit: gi|256379310|ref|YP_003102970.1| oxidoreductase 698973003606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698973003607 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698973003608 active site residue [active] 698973003609 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698973003610 active site residue [active] 698973003611 membrane ATPase/protein kinase; Provisional; Region: PRK09435 698973003612 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 698973003613 Walker A; other site 698973003614 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 698973003615 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 698973003616 active site 698973003617 substrate binding site [chemical binding]; other site 698973003618 coenzyme B12 binding site [chemical binding]; other site 698973003619 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 698973003620 B12 binding site [chemical binding]; other site 698973003621 cobalt ligand [ion binding]; other site 698973003622 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 698973003623 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 698973003624 heterodimer interface [polypeptide binding]; other site 698973003625 substrate interaction site [chemical binding]; other site 698973003626 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 698973003627 Uncharacterized conserved protein [Function unknown]; Region: COG0398 698973003628 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 698973003629 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698973003630 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 698973003631 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 698973003632 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 698973003633 ferrochelatase; Reviewed; Region: hemH; PRK00035 698973003634 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 698973003635 C-terminal domain interface [polypeptide binding]; other site 698973003636 active site 698973003637 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 698973003638 active site 698973003639 N-terminal domain interface [polypeptide binding]; other site 698973003640 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698973003641 NlpC/P60 family; Region: NLPC_P60; pfam00877 698973003642 aconitate hydratase; Validated; Region: PRK09277 698973003643 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698973003644 substrate binding site [chemical binding]; other site 698973003645 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698973003646 ligand binding site [chemical binding]; other site 698973003647 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 698973003648 substrate binding site [chemical binding]; other site 698973003649 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698973003650 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698973003651 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 698973003652 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 698973003653 catalytic triad [active] 698973003654 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 698973003655 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 698973003656 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698973003657 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698973003658 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973003659 Walker A/P-loop; other site 698973003660 ATP binding site [chemical binding]; other site 698973003661 Q-loop/lid; other site 698973003662 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698973003663 ABC transporter signature motif; other site 698973003664 Walker B; other site 698973003665 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698973003666 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 698973003667 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 698973003668 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 698973003669 trimerization site [polypeptide binding]; other site 698973003670 active site 698973003671 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698973003672 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 698973003673 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698973003674 catalytic residue [active] 698973003675 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 698973003676 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 698973003677 Walker A/P-loop; other site 698973003678 ATP binding site [chemical binding]; other site 698973003679 Q-loop/lid; other site 698973003680 ABC transporter signature motif; other site 698973003681 Walker B; other site 698973003682 D-loop; other site 698973003683 H-loop/switch region; other site 698973003684 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 698973003685 FeS assembly protein SufD; Region: sufD; TIGR01981 698973003686 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 698973003687 FeS assembly protein SufB; Region: sufB; TIGR01980 698973003688 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698973003689 Predicted transcriptional regulator [Transcription]; Region: COG2345 698973003690 putative DNA binding site [nucleotide binding]; other site 698973003691 putative Zn2+ binding site [ion binding]; other site 698973003692 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698973003693 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698973003694 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698973003695 Walker A/P-loop; other site 698973003696 ATP binding site [chemical binding]; other site 698973003697 Q-loop/lid; other site 698973003698 ABC transporter signature motif; other site 698973003699 Walker B; other site 698973003700 D-loop; other site 698973003701 H-loop/switch region; other site 698973003702 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698973003703 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698973003704 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 698973003705 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 698973003706 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 698973003707 UbiA prenyltransferase family; Region: UbiA; pfam01040 698973003708 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 698973003709 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 698973003710 TPP-binding site [chemical binding]; other site 698973003711 dimer interface [polypeptide binding]; other site 698973003712 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698973003713 PYR/PP interface [polypeptide binding]; other site 698973003714 dimer interface [polypeptide binding]; other site 698973003715 TPP binding site [chemical binding]; other site 698973003716 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698973003717 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 698973003718 putative active site [active] 698973003719 transaldolase; Provisional; Region: PRK03903 698973003720 catalytic residue [active] 698973003721 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 698973003722 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 698973003723 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 698973003724 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 698973003725 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 698973003726 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698973003727 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 698973003728 putative active site [active] 698973003729 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 698973003730 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 698973003731 triosephosphate isomerase; Provisional; Region: PRK14567 698973003732 substrate binding site [chemical binding]; other site 698973003733 dimer interface [polypeptide binding]; other site 698973003734 catalytic triad [active] 698973003735 Phosphoglycerate kinase; Region: PGK; pfam00162 698973003736 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 698973003737 substrate binding site [chemical binding]; other site 698973003738 hinge regions; other site 698973003739 ADP binding site [chemical binding]; other site 698973003740 catalytic site [active] 698973003741 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 698973003742 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 698973003743 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698973003744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 698973003745 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 698973003746 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 698973003747 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 698973003748 phosphate binding site [ion binding]; other site 698973003749 putative substrate binding pocket [chemical binding]; other site 698973003750 dimer interface [polypeptide binding]; other site 698973003751 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 698973003752 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 698973003753 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 698973003754 GIY-YIG motif/motif A; other site 698973003755 active site 698973003756 catalytic site [active] 698973003757 putative DNA binding site [nucleotide binding]; other site 698973003758 metal binding site [ion binding]; metal-binding site 698973003759 UvrB/uvrC motif; Region: UVR; pfam02151 698973003760 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 698973003761 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698973003762 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 698973003763 homopentamer interface [polypeptide binding]; other site 698973003764 active site 698973003765 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 698973003766 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 698973003767 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 698973003768 dimerization interface [polypeptide binding]; other site 698973003769 active site 698973003770 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 698973003771 Lumazine binding domain; Region: Lum_binding; pfam00677 698973003772 Lumazine binding domain; Region: Lum_binding; pfam00677 698973003773 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 698973003774 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 698973003775 catalytic motif [active] 698973003776 Zn binding site [ion binding]; other site 698973003777 RibD C-terminal domain; Region: RibD_C; pfam01872 698973003778 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 698973003779 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 698973003780 substrate binding site [chemical binding]; other site 698973003781 hexamer interface [polypeptide binding]; other site 698973003782 metal binding site [ion binding]; metal-binding site 698973003783 16S rRNA methyltransferase B; Provisional; Region: PRK14902 698973003784 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 698973003785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698973003786 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 698973003787 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 698973003788 putative active site [active] 698973003789 substrate binding site [chemical binding]; other site 698973003790 putative cosubstrate binding site; other site 698973003791 catalytic site [active] 698973003792 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 698973003793 substrate binding site [chemical binding]; other site 698973003794 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698973003795 active site 698973003796 catalytic residues [active] 698973003797 metal binding site [ion binding]; metal-binding site 698973003798 primosome assembly protein PriA; Provisional; Region: PRK14873 698973003799 S-adenosylmethionine synthetase; Validated; Region: PRK05250 698973003800 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 698973003801 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 698973003802 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 698973003803 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 698973003804 Flavoprotein; Region: Flavoprotein; pfam02441 698973003805 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 698973003806 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 698973003807 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 698973003808 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 698973003809 catalytic site [active] 698973003810 G-X2-G-X-G-K; other site 698973003811 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 698973003812 active site 698973003813 dimer interface [polypeptide binding]; other site 698973003814 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 698973003815 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698973003816 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698973003817 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 698973003818 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698973003819 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698973003820 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 698973003821 IMP binding site; other site 698973003822 dimer interface [polypeptide binding]; other site 698973003823 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 698973003824 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 698973003825 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 698973003826 catalytic site [active] 698973003827 subunit interface [polypeptide binding]; other site 698973003828 dihydroorotase; Validated; Region: pyrC; PRK09357 698973003829 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698973003830 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 698973003831 active site 698973003832 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 698973003833 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698973003834 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698973003835 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 698973003836 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698973003837 active site 698973003838 hydrophobic ligand binding site; other site 698973003839 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698973003840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698973003841 TIGR01777 family protein; Region: yfcH 698973003842 NAD(P) binding site [chemical binding]; other site 698973003843 active site 698973003844 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 698973003845 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 698973003846 elongation factor P; Validated; Region: PRK00529 698973003847 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 698973003848 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 698973003849 RNA binding site [nucleotide binding]; other site 698973003850 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 698973003851 RNA binding site [nucleotide binding]; other site 698973003852 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698973003853 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698973003854 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698973003855 active site 698973003856 Dehydroquinase class II; Region: DHquinase_II; pfam01220 698973003857 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 698973003858 trimer interface [polypeptide binding]; other site 698973003859 active site 698973003860 dimer interface [polypeptide binding]; other site 698973003861 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 698973003862 active site 698973003863 dimer interface [polypeptide binding]; other site 698973003864 metal binding site [ion binding]; metal-binding site 698973003865 shikimate kinase; Reviewed; Region: aroK; PRK00131 698973003866 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 698973003867 ADP binding site [chemical binding]; other site 698973003868 magnesium binding site [ion binding]; other site 698973003869 putative shikimate binding site; other site 698973003870 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 698973003871 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 698973003872 Tetramer interface [polypeptide binding]; other site 698973003873 active site 698973003874 FMN-binding site [chemical binding]; other site 698973003875 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 698973003876 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698973003877 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698973003878 shikimate binding site; other site 698973003879 NAD(P) binding site [chemical binding]; other site 698973003880 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 698973003881 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 698973003882 dimerization interface [polypeptide binding]; other site 698973003883 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 698973003884 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 698973003885 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 698973003886 motif 1; other site 698973003887 active site 698973003888 motif 2; other site 698973003889 motif 3; other site 698973003890 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698973003891 DHHA1 domain; Region: DHHA1; pfam02272 698973003892 recombination factor protein RarA; Reviewed; Region: PRK13342 698973003893 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698973003894 Walker A motif; other site 698973003895 ATP binding site [chemical binding]; other site 698973003896 Walker B motif; other site 698973003897 arginine finger; other site 698973003898 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 698973003899 Phosphotransferase enzyme family; Region: APH; pfam01636 698973003900 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698973003901 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 698973003902 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 698973003903 dimer interface [polypeptide binding]; other site 698973003904 anticodon binding site; other site 698973003905 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 698973003906 homodimer interface [polypeptide binding]; other site 698973003907 motif 1; other site 698973003908 active site 698973003909 motif 2; other site 698973003910 GAD domain; Region: GAD; pfam02938 698973003911 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698973003912 active site 698973003913 motif 3; other site 698973003914 Predicted metalloprotease [General function prediction only]; Region: COG2321 698973003915 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 698973003916 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698973003917 ATP binding site [chemical binding]; other site 698973003918 putative Mg++ binding site [ion binding]; other site 698973003919 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698973003920 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 698973003921 nucleotide binding region [chemical binding]; other site 698973003922 ATP-binding site [chemical binding]; other site 698973003923 Predicted membrane protein [Function unknown]; Region: COG1511 698973003924 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698973003925 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698973003926 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698973003927 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698973003928 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698973003929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973003930 Q-loop/lid; other site 698973003931 ABC transporter signature motif; other site 698973003932 Walker B; other site 698973003933 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698973003934 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698973003935 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698973003936 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698973003937 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698973003938 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 698973003939 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 698973003940 dimer interface [polypeptide binding]; other site 698973003941 motif 1; other site 698973003942 active site 698973003943 motif 2; other site 698973003944 motif 3; other site 698973003945 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 698973003946 anticodon binding site; other site 698973003947 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698973003948 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 698973003949 dimer interface [polypeptide binding]; other site 698973003950 catalytic triad [active] 698973003951 peroxidatic and resolving cysteines [active] 698973003952 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698973003953 active site 698973003954 MULE transposase domain; Region: MULE; pfam10551 698973003955 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698973003956 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698973003957 Zn2+ binding site [ion binding]; other site 698973003958 Mg2+ binding site [ion binding]; other site 698973003959 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698973003960 synthetase active site [active] 698973003961 NTP binding site [chemical binding]; other site 698973003962 metal binding site [ion binding]; metal-binding site 698973003963 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 698973003964 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 698973003965 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698973003966 active site 698973003967 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 698973003968 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698973003969 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 698973003970 Protein export membrane protein; Region: SecD_SecF; cl14618 698973003971 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 698973003972 Protein export membrane protein; Region: SecD_SecF; cl14618 698973003973 Preprotein translocase subunit; Region: YajC; pfam02699 698973003974 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 698973003975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698973003976 Walker A motif; other site 698973003977 ATP binding site [chemical binding]; other site 698973003978 Walker B motif; other site 698973003979 arginine finger; other site 698973003980 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 698973003981 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 698973003982 RuvA N terminal domain; Region: RuvA_N; pfam01330 698973003983 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 698973003984 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 698973003985 active site 698973003986 putative DNA-binding cleft [nucleotide binding]; other site 698973003987 dimer interface [polypeptide binding]; other site 698973003988 hypothetical protein; Validated; Region: PRK00110 698973003989 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 698973003990 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 698973003991 active site 698973003992 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 698973003993 catalytic triad [active] 698973003994 dimer interface [polypeptide binding]; other site 698973003995 HTH-like domain; Region: HTH_21; pfam13276 698973003996 Integrase core domain; Region: rve; pfam00665 698973003997 potential frameshift: common BLAST hit: gi|38233368|ref|NP_939135.1| transposase 698973003998 Helix-turn-helix domain; Region: HTH_38; pfam13936 698973003999 putative transposase OrfB; Reviewed; Region: PHA02517 698973004000 HTH-like domain; Region: HTH_21; pfam13276 698973004001 Integrase core domain; Region: rve; pfam00665 698973004002 Integrase core domain; Region: rve_2; pfam13333 698973004003 Helix-turn-helix domain; Region: HTH_28; pfam13518 698973004004 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698973004005 Integrase core domain; Region: rve; pfam00665 698973004006 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 698973004007 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 698973004008 Nitronate monooxygenase; Region: NMO; pfam03060 698973004009 FMN binding site [chemical binding]; other site 698973004010 substrate binding site [chemical binding]; other site 698973004011 putative catalytic residue [active] 698973004012 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 698973004013 Replicase family; Region: Replicase; pfam03090 698973004014 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 698973004015 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698973004016 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698973004017 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698973004018 catalytic residues [active] 698973004019 catalytic nucleophile [active] 698973004020 Presynaptic Site I dimer interface [polypeptide binding]; other site 698973004021 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698973004022 Synaptic Flat tetramer interface [polypeptide binding]; other site 698973004023 Synaptic Site I dimer interface [polypeptide binding]; other site 698973004024 DNA binding site [nucleotide binding] 698973004025 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698973004026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698973004027 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698973004028 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698973004029 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698973004030 non-specific DNA binding site [nucleotide binding]; other site 698973004031 salt bridge; other site 698973004032 sequence-specific DNA binding site [nucleotide binding]; other site 698973004033 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698973004034 MULE transposase domain; Region: MULE; pfam10551 698973004035 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698973004036 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698973004037 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 698973004038 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 698973004039 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698973004040 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698973004041 catalytic residue [active] 698973004042 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698973004043 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698973004044 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 698973004045 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 698973004046 putative acyl-acceptor binding pocket; other site 698973004047 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698973004048 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 698973004049 nucleotide binding site/active site [active] 698973004050 HIT family signature motif; other site 698973004051 catalytic residue [active] 698973004052 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 698973004053 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698973004054 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 698973004055 active site 698973004056 dimer interface [polypeptide binding]; other site 698973004057 motif 1; other site 698973004058 motif 2; other site 698973004059 motif 3; other site 698973004060 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 698973004061 anticodon binding site; other site 698973004062 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 698973004063 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 698973004064 Protein of unknown function (DUF461); Region: DUF461; pfam04314 698973004065 CopC domain; Region: CopC; cl01012 698973004066 hypothetical protein; Provisional; Region: PRK14059 698973004067 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 698973004068 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 698973004069 SelR domain; Region: SelR; pfam01641 698973004070 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 698973004071 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 698973004072 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 698973004073 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 698973004074 catalytic site [active] 698973004075 putative active site [active] 698973004076 putative substrate binding site [chemical binding]; other site 698973004077 HRDC domain; Region: HRDC; pfam00570 698973004078 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 698973004079 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 698973004080 TPP-binding site; other site 698973004081 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698973004082 PYR/PP interface [polypeptide binding]; other site 698973004083 dimer interface [polypeptide binding]; other site 698973004084 TPP binding site [chemical binding]; other site 698973004085 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698973004086 TRAM domain; Region: TRAM; cl01282 698973004087 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 698973004088 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 698973004089 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698973004090 trimer interface [polypeptide binding]; other site 698973004091 active site 698973004092 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 698973004093 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 698973004094 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698973004095 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 698973004096 active site 698973004097 dimerization interface [polypeptide binding]; other site 698973004098 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698973004099 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698973004100 nucleotide binding site [chemical binding]; other site 698973004101 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698973004102 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698973004103 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698973004104 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698973004105 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698973004106 DNA binding residues [nucleotide binding] 698973004107 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698973004108 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698973004109 ATP binding site [chemical binding]; other site 698973004110 putative Mg++ binding site [ion binding]; other site 698973004111 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 698973004112 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 698973004113 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 698973004114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698973004115 S-adenosylmethionine binding site [chemical binding]; other site 698973004116 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 698973004117 putative active site [active] 698973004118 dimerization interface [polypeptide binding]; other site 698973004119 putative tRNAtyr binding site [nucleotide binding]; other site 698973004120 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698973004121 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698973004122 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698973004123 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698973004124 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698973004125 DNA binding residues [nucleotide binding] 698973004126 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698973004127 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698973004128 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698973004129 FeoA domain; Region: FeoA; cl00838 698973004130 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 698973004131 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 698973004132 NAD binding site [chemical binding]; other site 698973004133 homodimer interface [polypeptide binding]; other site 698973004134 active site 698973004135 substrate binding site [chemical binding]; other site 698973004136 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 698973004137 PAC2 family; Region: PAC2; pfam09754 698973004138 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698973004139 ATP binding site [chemical binding]; other site 698973004140 putative Mg++ binding site [ion binding]; other site 698973004141 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698973004142 nucleotide binding region [chemical binding]; other site 698973004143 ATP-binding site [chemical binding]; other site 698973004144 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 698973004145 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 698973004146 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 698973004147 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698973004148 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 698973004149 dimer interface [polypeptide binding]; other site 698973004150 decamer (pentamer of dimers) interface [polypeptide binding]; other site 698973004151 catalytic triad [active] 698973004152 peroxidatic and resolving cysteines [active] 698973004153 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698973004154 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 698973004155 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 698973004156 dimerization interface [polypeptide binding]; other site 698973004157 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 698973004158 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698973004159 ATP binding site [chemical binding]; other site 698973004160 putative Mg++ binding site [ion binding]; other site 698973004161 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698973004162 nucleotide binding region [chemical binding]; other site 698973004163 ATP-binding site [chemical binding]; other site 698973004164 Helicase associated domain (HA2); Region: HA2; pfam04408 698973004165 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 698973004166 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 698973004167 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 698973004168 ATP cone domain; Region: ATP-cone; pfam03477 698973004169 LexA repressor; Validated; Region: PRK00215 698973004170 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 698973004171 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698973004172 Catalytic site [active] 698973004173 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698973004174 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 698973004175 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698973004176 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 698973004177 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 698973004178 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 698973004179 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 698973004180 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698973004181 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698973004182 DNA-binding site [nucleotide binding]; DNA binding site 698973004183 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698973004184 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 698973004185 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 698973004186 putative substrate binding site [chemical binding]; other site 698973004187 putative ATP binding site [chemical binding]; other site 698973004188 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698973004189 dimerization domain swap beta strand [polypeptide binding]; other site 698973004190 regulatory protein interface [polypeptide binding]; other site 698973004191 active site 698973004192 regulatory phosphorylation site [posttranslational modification]; other site 698973004193 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 698973004194 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698973004195 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 698973004196 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698973004197 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 698973004198 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 698973004199 GTPases [General function prediction only]; Region: HflX; COG2262 698973004200 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 698973004201 HflX GTPase family; Region: HflX; cd01878 698973004202 G1 box; other site 698973004203 GTP/Mg2+ binding site [chemical binding]; other site 698973004204 Switch I region; other site 698973004205 G2 box; other site 698973004206 G3 box; other site 698973004207 Switch II region; other site 698973004208 G4 box; other site 698973004209 G5 box; other site 698973004210 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 698973004211 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698973004212 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698973004213 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 698973004214 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 698973004215 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698973004216 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698973004217 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698973004218 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698973004219 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 698973004220 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 698973004221 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698973004222 FeS/SAM binding site; other site 698973004223 recombination regulator RecX; Reviewed; Region: recX; PRK00117 698973004224 recombinase A; Provisional; Region: recA; PRK09354 698973004225 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 698973004226 hexamer interface [polypeptide binding]; other site 698973004227 Walker A motif; other site 698973004228 ATP binding site [chemical binding]; other site 698973004229 Walker B motif; other site 698973004230 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 698973004231 BioY family; Region: BioY; pfam02632 698973004232 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698973004233 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698973004234 Walker A/P-loop; other site 698973004235 ATP binding site [chemical binding]; other site 698973004236 Q-loop/lid; other site 698973004237 ABC transporter signature motif; other site 698973004238 Walker B; other site 698973004239 D-loop; other site 698973004240 H-loop/switch region; other site 698973004241 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698973004242 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698973004243 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698973004244 sequence-specific DNA binding site [nucleotide binding]; other site 698973004245 salt bridge; other site 698973004246 Competence-damaged protein; Region: CinA; pfam02464 698973004247 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698973004248 YCII-related domain; Region: YCII; cl00999 698973004249 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 698973004250 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 698973004251 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698973004252 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 698973004253 TIGR03085 family protein; Region: TIGR03085 698973004254 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 698973004255 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698973004256 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 698973004257 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 698973004258 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698973004259 dimer interface [polypeptide binding]; other site 698973004260 active site 698973004261 catalytic residue [active] 698973004262 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 698973004263 dihydrodipicolinate reductase; Provisional; Region: PRK00048 698973004264 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 698973004265 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 698973004266 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 698973004267 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 698973004268 oligomer interface [polypeptide binding]; other site 698973004269 RNA binding site [nucleotide binding]; other site 698973004270 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 698973004271 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 698973004272 RNase E interface [polypeptide binding]; other site 698973004273 trimer interface [polypeptide binding]; other site 698973004274 active site 698973004275 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 698973004276 putative nucleic acid binding region [nucleotide binding]; other site 698973004277 G-X-X-G motif; other site 698973004278 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 698973004279 RNA binding site [nucleotide binding]; other site 698973004280 domain interface; other site 698973004281 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 698973004282 16S/18S rRNA binding site [nucleotide binding]; other site 698973004283 S13e-L30e interaction site [polypeptide binding]; other site 698973004284 25S rRNA binding site [nucleotide binding]; other site 698973004285 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 698973004286 active site 698973004287 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 698973004288 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 698973004289 active site 698973004290 Riboflavin kinase; Region: Flavokinase; smart00904 698973004291 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 698973004292 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 698973004293 RNA binding site [nucleotide binding]; other site 698973004294 active site 698973004295 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 698973004296 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 698973004297 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698973004298 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698973004299 active site 698973004300 metal binding site [ion binding]; metal-binding site 698973004301 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698973004302 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 698973004303 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 698973004304 DHH family; Region: DHH; pfam01368 698973004305 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 698973004306 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698973004307 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698973004308 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 698973004309 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 698973004310 G1 box; other site 698973004311 putative GEF interaction site [polypeptide binding]; other site 698973004312 GTP/Mg2+ binding site [chemical binding]; other site 698973004313 Switch I region; other site 698973004314 G2 box; other site 698973004315 G3 box; other site 698973004316 Switch II region; other site 698973004317 G4 box; other site 698973004318 G5 box; other site 698973004319 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 698973004320 Translation-initiation factor 2; Region: IF-2; pfam11987 698973004321 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 698973004322 Protein of unknown function (DUF448); Region: DUF448; pfam04296 698973004323 putative RNA binding cleft [nucleotide binding]; other site 698973004324 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 698973004325 NusA N-terminal domain; Region: NusA_N; pfam08529 698973004326 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 698973004327 RNA binding site [nucleotide binding]; other site 698973004328 homodimer interface [polypeptide binding]; other site 698973004329 NusA-like KH domain; Region: KH_5; pfam13184 698973004330 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 698973004331 G-X-X-G motif; other site 698973004332 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 698973004333 Sm and related proteins; Region: Sm_like; cl00259 698973004334 prolyl-tRNA synthetase; Provisional; Region: PRK09194 698973004335 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 698973004336 dimer interface [polypeptide binding]; other site 698973004337 motif 1; other site 698973004338 active site 698973004339 motif 2; other site 698973004340 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 698973004341 putative deacylase active site [active] 698973004342 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698973004343 active site 698973004344 motif 3; other site 698973004345 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 698973004346 anticodon binding site; other site 698973004347 hypothetical protein; Validated; Region: PRK02101 698973004348 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 698973004349 active site 698973004350 SAM binding site [chemical binding]; other site 698973004351 homodimer interface [polypeptide binding]; other site 698973004352 Uncharacterized conserved protein [Function unknown]; Region: COG0397 698973004353 hypothetical protein; Validated; Region: PRK00029 698973004354 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698973004355 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 698973004356 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 698973004357 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 698973004358 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 698973004359 DNA binding site [nucleotide binding] 698973004360 active site 698973004361 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 698973004362 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698973004363 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 698973004364 catalytic triad [active] 698973004365 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 698973004366 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 698973004367 Walker A motif; other site 698973004368 homodimer interface [polypeptide binding]; other site 698973004369 ATP binding site [chemical binding]; other site 698973004370 hydroxycobalamin binding site [chemical binding]; other site 698973004371 Walker B motif; other site 698973004372 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 698973004373 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 698973004374 metal ion-dependent adhesion site (MIDAS); other site 698973004375 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 698973004376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698973004377 Walker A motif; other site 698973004378 ATP binding site [chemical binding]; other site 698973004379 Walker B motif; other site 698973004380 arginine finger; other site 698973004381 putative transposase OrfB; Reviewed; Region: PHA02517 698973004382 HTH-like domain; Region: HTH_21; pfam13276 698973004383 Integrase core domain; Region: rve; pfam00665 698973004384 Integrase core domain; Region: rve_2; pfam13333 698973004385 Homeodomain-like domain; Region: HTH_23; cl17451 698973004386 Helix-turn-helix domain; Region: HTH_28; pfam13518 698973004387 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698973004388 Integrase core domain; Region: rve; pfam00665 698973004389 malate:quinone oxidoreductase; Validated; Region: PRK05257 698973004390 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 698973004391 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698973004392 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698973004393 mycothione reductase; Region: mycothione_red; TIGR03452 698973004394 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698973004395 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698973004396 cobyric acid synthase; Provisional; Region: PRK00784 698973004397 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 698973004398 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698973004399 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698973004400 catalytic triad [active] 698973004401 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698973004402 active site 698973004403 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 698973004404 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698973004405 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 698973004406 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698973004407 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698973004408 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 698973004409 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698973004410 active site 698973004411 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 698973004412 protein binding site [polypeptide binding]; other site 698973004413 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 698973004414 putative substrate binding region [chemical binding]; other site 698973004415 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 698973004416 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 698973004417 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 698973004418 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 698973004419 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 698973004420 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 698973004421 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698973004422 FeS/SAM binding site; other site 698973004423 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 698973004424 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 698973004425 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 698973004426 ribosome recycling factor; Reviewed; Region: frr; PRK00083 698973004427 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 698973004428 hinge region; other site 698973004429 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 698973004430 putative nucleotide binding site [chemical binding]; other site 698973004431 uridine monophosphate binding site [chemical binding]; other site 698973004432 homohexameric interface [polypeptide binding]; other site 698973004433 elongation factor Ts; Provisional; Region: tsf; PRK09377 698973004434 UBA/TS-N domain; Region: UBA; pfam00627 698973004435 Elongation factor TS; Region: EF_TS; pfam00889 698973004436 Elongation factor TS; Region: EF_TS; pfam00889 698973004437 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 698973004438 rRNA interaction site [nucleotide binding]; other site 698973004439 S8 interaction site; other site 698973004440 putative laminin-1 binding site; other site 698973004441 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698973004442 Peptidase family M23; Region: Peptidase_M23; pfam01551 698973004443 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698973004444 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 698973004445 active site 698973004446 DNA binding site [nucleotide binding] 698973004447 Int/Topo IB signature motif; other site 698973004448 DNA protecting protein DprA; Region: dprA; TIGR00732 698973004449 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 698973004450 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 698973004451 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698973004452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698973004453 Walker A motif; other site 698973004454 ATP binding site [chemical binding]; other site 698973004455 Walker B motif; other site 698973004456 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 698973004457 hypothetical protein; Reviewed; Region: PRK12497 698973004458 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 698973004459 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 698973004460 RNA/DNA hybrid binding site [nucleotide binding]; other site 698973004461 active site 698973004462 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 698973004463 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698973004464 Catalytic site [active] 698973004465 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698973004466 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 698973004467 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 698973004468 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 698973004469 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 698973004470 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698973004471 RNA binding site [nucleotide binding]; other site 698973004472 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 698973004473 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 698973004474 RimM N-terminal domain; Region: RimM; pfam01782 698973004475 PRC-barrel domain; Region: PRC; pfam05239 698973004476 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 698973004477 signal recognition particle protein; Provisional; Region: PRK10867 698973004478 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 698973004479 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 698973004480 P loop; other site 698973004481 GTP binding site [chemical binding]; other site 698973004482 Signal peptide binding domain; Region: SRP_SPB; pfam02978 698973004483 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 698973004484 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698973004485 metal binding triad; other site 698973004486 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698973004487 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 698973004488 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 698973004489 Nitrogen regulatory protein P-II; Region: P-II; smart00938 698973004490 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 698973004491 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 698973004492 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698973004493 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 698973004494 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698973004495 Walker A/P-loop; other site 698973004496 ATP binding site [chemical binding]; other site 698973004497 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 698973004498 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698973004499 ABC transporter signature motif; other site 698973004500 Walker B; other site 698973004501 D-loop; other site 698973004502 H-loop/switch region; other site 698973004503 Acylphosphatase; Region: Acylphosphatase; cl00551 698973004504 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698973004505 amino acid carrier protein; Region: agcS; TIGR00835 698973004506 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 698973004507 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 698973004508 DNA binding site [nucleotide binding] 698973004509 catalytic residue [active] 698973004510 H2TH interface [polypeptide binding]; other site 698973004511 putative catalytic residues [active] 698973004512 turnover-facilitating residue; other site 698973004513 intercalation triad [nucleotide binding]; other site 698973004514 8OG recognition residue [nucleotide binding]; other site 698973004515 putative reading head residues; other site 698973004516 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698973004517 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698973004518 ribonuclease III; Reviewed; Region: rnc; PRK00102 698973004519 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 698973004520 dimerization interface [polypeptide binding]; other site 698973004521 active site 698973004522 metal binding site [ion binding]; metal-binding site 698973004523 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 698973004524 dsRNA binding site [nucleotide binding]; other site 698973004525 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 698973004526 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698973004527 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 698973004528 glutamate dehydrogenase; Provisional; Region: PRK09414 698973004529 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 698973004530 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 698973004531 NAD(P) binding site [chemical binding]; other site 698973004532 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 698973004533 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698973004534 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698973004535 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 698973004536 metal binding site [ion binding]; metal-binding site 698973004537 putative dimer interface [polypeptide binding]; other site 698973004538 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 698973004539 homodimer interface [polypeptide binding]; other site 698973004540 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 698973004541 active site pocket [active] 698973004542 pyruvate kinase; Provisional; Region: PRK06247 698973004543 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 698973004544 domain interfaces; other site 698973004545 active site 698973004546 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 698973004547 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698973004548 active site 698973004549 ribulose/triose binding site [chemical binding]; other site 698973004550 phosphate binding site [ion binding]; other site 698973004551 substrate (anthranilate) binding pocket [chemical binding]; other site 698973004552 product (indole) binding pocket [chemical binding]; other site 698973004553 trp region conserved hypothetical membrane protein; Region: trp_oprn_chp; TIGR02234 698973004554 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 698973004555 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 698973004556 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698973004557 substrate binding site [chemical binding]; other site 698973004558 glutamase interaction surface [polypeptide binding]; other site 698973004559 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698973004560 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698973004561 active site 698973004562 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 698973004563 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698973004564 catalytic residues [active] 698973004565 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 698973004566 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 698973004567 putative active site [active] 698973004568 oxyanion strand; other site 698973004569 catalytic triad [active] 698973004570 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698973004571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973004572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973004573 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 698973004574 putative active site pocket [active] 698973004575 4-fold oligomerization interface [polypeptide binding]; other site 698973004576 metal binding residues [ion binding]; metal-binding site 698973004577 3-fold/trimer interface [polypeptide binding]; other site 698973004578 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 698973004579 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698973004580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698973004581 homodimer interface [polypeptide binding]; other site 698973004582 catalytic residue [active] 698973004583 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 698973004584 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 698973004585 NAD binding site [chemical binding]; other site 698973004586 dimerization interface [polypeptide binding]; other site 698973004587 product binding site; other site 698973004588 substrate binding site [chemical binding]; other site 698973004589 zinc binding site [ion binding]; other site 698973004590 catalytic residues [active] 698973004591 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 698973004592 tetracycline repressor protein TetR; Provisional; Region: PRK13756 698973004593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698973004594 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 698973004595 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 698973004596 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 698973004597 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 698973004598 active site 698973004599 catalytic site [active] 698973004600 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 698973004601 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 698973004602 active site 698973004603 catalytic site [active] 698973004604 substrate binding site [chemical binding]; other site 698973004605 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698973004606 synthetase active site [active] 698973004607 NTP binding site [chemical binding]; other site 698973004608 metal binding site [ion binding]; metal-binding site 698973004609 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698973004610 RNA binding surface [nucleotide binding]; other site 698973004611 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 698973004612 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 698973004613 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 698973004614 threonine dehydratase; Validated; Region: PRK08639 698973004615 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698973004616 tetramer interface [polypeptide binding]; other site 698973004617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698973004618 catalytic residue [active] 698973004619 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 698973004620 putative Ile/Val binding site [chemical binding]; other site 698973004621 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 698973004622 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 698973004623 active site 698973004624 PHP Thumb interface [polypeptide binding]; other site 698973004625 metal binding site [ion binding]; metal-binding site 698973004626 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698973004627 generic binding surface II; other site 698973004628 generic binding surface I; other site 698973004629 Predicted permeases [General function prediction only]; Region: RarD; COG2962 698973004630 EamA-like transporter family; Region: EamA; cl17759 698973004631 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698973004632 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698973004633 RNA binding surface [nucleotide binding]; other site 698973004634 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698973004635 active site 698973004636 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 698973004637 lipoprotein signal peptidase; Provisional; Region: PRK14787 698973004638 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698973004639 active site 698973004640 homotetramer interface [polypeptide binding]; other site 698973004641 homodimer interface [polypeptide binding]; other site 698973004642 DNA polymerase IV; Provisional; Region: PRK03348 698973004643 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 698973004644 active site 698973004645 DNA binding site [nucleotide binding] 698973004646 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 698973004647 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698973004648 HIGH motif; other site 698973004649 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698973004650 active site 698973004651 KMSKS motif; other site 698973004652 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 698973004653 tRNA binding surface [nucleotide binding]; other site 698973004654 anticodon binding site; other site 698973004655 DivIVA protein; Region: DivIVA; pfam05103 698973004656 DivIVA domain; Region: DivI1A_domain; TIGR03544 698973004657 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 698973004658 YGGT family; Region: YGGT; cl00508 698973004659 Protein of unknown function (DUF552); Region: DUF552; cl00775 698973004660 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 698973004661 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 698973004662 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 698973004663 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 698973004664 nucleotide binding site [chemical binding]; other site 698973004665 SulA interaction site; other site 698973004666 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 698973004667 Cell division protein FtsQ; Region: FtsQ; pfam03799 698973004668 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 698973004669 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698973004670 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698973004671 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698973004672 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 698973004673 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 698973004674 active site 698973004675 homodimer interface [polypeptide binding]; other site 698973004676 cell division protein FtsW; Region: ftsW; TIGR02614 698973004677 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 698973004678 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698973004679 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698973004680 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 698973004681 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 698973004682 Mg++ binding site [ion binding]; other site 698973004683 putative catalytic motif [active] 698973004684 putative substrate binding site [chemical binding]; other site 698973004685 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 698973004686 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698973004687 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698973004688 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698973004689 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 698973004690 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698973004691 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698973004692 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698973004693 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698973004694 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698973004695 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698973004696 MraW methylase family; Region: Methyltransf_5; cl17771 698973004697 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 698973004698 cell division protein MraZ; Reviewed; Region: PRK00326 698973004699 MraZ protein; Region: MraZ; pfam02381 698973004700 MraZ protein; Region: MraZ; pfam02381 698973004701 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 698973004702 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698973004703 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698973004704 Coenzyme A binding pocket [chemical binding]; other site 698973004705 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 698973004706 FAD binding site [chemical binding]; other site 698973004707 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698973004708 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698973004709 substrate binding pocket [chemical binding]; other site 698973004710 chain length determination region; other site 698973004711 substrate-Mg2+ binding site; other site 698973004712 catalytic residues [active] 698973004713 aspartate-rich region 1; other site 698973004714 active site lid residues [active] 698973004715 aspartate-rich region 2; other site 698973004716 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698973004717 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698973004718 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698973004719 active site 698973004720 ATP binding site [chemical binding]; other site 698973004721 substrate binding site [chemical binding]; other site 698973004722 activation loop (A-loop); other site 698973004723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698973004724 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698973004725 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698973004726 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698973004727 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698973004728 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 698973004729 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698973004730 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698973004731 putative acyl-acceptor binding pocket; other site 698973004732 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698973004733 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698973004734 nucleotide binding site [chemical binding]; other site 698973004735 Tesmin/TSO1-like CXC domain; Region: CXC; pfam03638 698973004736 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698973004737 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698973004738 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698973004739 NlpC/P60 family; Region: NLPC_P60; pfam00877 698973004740 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698973004741 NlpC/P60 family; Region: NLPC_P60; pfam00877 698973004742 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 698973004743 heme bH binding site [chemical binding]; other site 698973004744 intrachain domain interface; other site 698973004745 heme bL binding site [chemical binding]; other site 698973004746 interchain domain interface [polypeptide binding]; other site 698973004747 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 698973004748 Qo binding site; other site 698973004749 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 698973004750 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698973004751 iron-sulfur cluster [ion binding]; other site 698973004752 [2Fe-2S] cluster binding site [ion binding]; other site 698973004753 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698973004754 Cytochrome c; Region: Cytochrom_C; pfam00034 698973004755 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698973004756 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 698973004757 Subunit I/III interface [polypeptide binding]; other site 698973004758 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 698973004759 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 698973004760 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 698973004761 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 698973004762 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 698973004763 active site 698973004764 dimer interface [polypeptide binding]; other site 698973004765 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 698973004766 Ligand Binding Site [chemical binding]; other site 698973004767 Molecular Tunnel; other site 698973004768 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 698973004769 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 698973004770 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 698973004771 homotrimer interface [polypeptide binding]; other site 698973004772 Walker A motif; other site 698973004773 GTP binding site [chemical binding]; other site 698973004774 Walker B motif; other site 698973004775 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 698973004776 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 698973004777 putative dimer interface [polypeptide binding]; other site 698973004778 active site pocket [active] 698973004779 putative cataytic base [active] 698973004780 cobalamin synthase; Reviewed; Region: cobS; PRK00235 698973004781 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 698973004782 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 698973004783 homodimer interface [polypeptide binding]; other site 698973004784 substrate-cofactor binding pocket; other site 698973004785 catalytic residue [active] 698973004786 multifunctional aminopeptidase A; Provisional; Region: PRK00913 698973004787 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 698973004788 interface (dimer of trimers) [polypeptide binding]; other site 698973004789 Substrate-binding/catalytic site; other site 698973004790 Zn-binding sites [ion binding]; other site 698973004791 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 698973004792 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698973004793 E3 interaction surface; other site 698973004794 lipoyl attachment site [posttranslational modification]; other site 698973004795 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698973004796 E3 interaction surface; other site 698973004797 lipoyl attachment site [posttranslational modification]; other site 698973004798 e3 binding domain; Region: E3_binding; pfam02817 698973004799 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698973004800 lipoate-protein ligase B; Provisional; Region: PRK14345 698973004801 lipoyl synthase; Provisional; Region: PRK05481 698973004802 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698973004803 FeS/SAM binding site; other site 698973004804 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 698973004805 RDD family; Region: RDD; pfam06271 698973004806 glutamine synthetase, type I; Region: GlnA; TIGR00653 698973004807 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698973004808 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698973004809 Predicted peptidase [General function prediction only]; Region: COG4099 698973004810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 698973004811 Predicted permease [General function prediction only]; Region: COG2056 698973004812 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 698973004813 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698973004814 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698973004815 DNA-binding site [nucleotide binding]; DNA binding site 698973004816 FCD domain; Region: FCD; pfam07729 698973004817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973004818 putative substrate translocation pore; other site 698973004819 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 698973004820 nudix motif; other site 698973004821 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 698973004822 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 698973004823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698973004824 catalytic residue [active] 698973004825 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 698973004826 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 698973004827 heme binding pocket [chemical binding]; other site 698973004828 heme ligand [chemical binding]; other site 698973004829 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 698973004830 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698973004831 metal binding triad; other site 698973004832 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698973004833 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698973004834 metal binding triad; other site 698973004835 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698973004836 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 698973004837 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698973004838 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698973004839 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 698973004840 putative active site; other site 698973004841 putative metal binding residues [ion binding]; other site 698973004842 signature motif; other site 698973004843 putative triphosphate binding site [ion binding]; other site 698973004844 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 698973004845 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 698973004846 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698973004847 potential frameshift: common BLAST hit: gi|300858911|ref|YP_003783894.1| ribonuclease R 698973004848 RNB domain; Region: RNB; pfam00773 698973004849 Predicted membrane protein [General function prediction only]; Region: COG4194 698973004850 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 698973004851 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 698973004852 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 698973004853 RNA/DNA hybrid binding site [nucleotide binding]; other site 698973004854 active site 698973004855 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698973004856 catalytic core [active] 698973004857 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 698973004858 Putative zinc ribbon domain; Region: DUF164; pfam02591 698973004859 Uncharacterized conserved protein [Function unknown]; Region: COG0327 698973004860 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698973004861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 698973004862 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698973004863 hypothetical protein; Provisional; Region: PRK07908 698973004864 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698973004865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698973004866 homodimer interface [polypeptide binding]; other site 698973004867 catalytic residue [active] 698973004868 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 698973004869 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698973004870 motif II; other site 698973004871 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 698973004872 Low molecular weight phosphatase family; Region: LMWPc; cd00115 698973004873 active site 698973004874 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 698973004875 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 698973004876 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 698973004877 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 698973004878 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 698973004879 dimer interface [polypeptide binding]; other site 698973004880 TPP-binding site [chemical binding]; other site 698973004881 Electron transfer DM13; Region: DM13; pfam10517 698973004882 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698973004883 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698973004884 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698973004885 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 698973004886 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698973004887 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698973004888 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698973004889 active site 698973004890 motif I; other site 698973004891 motif II; other site 698973004892 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698973004893 motif II; other site 698973004894 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698973004895 Beta-lactamase; Region: Beta-lactamase; pfam00144 698973004896 Predicted membrane protein [Function unknown]; Region: COG2860 698973004897 UPF0126 domain; Region: UPF0126; pfam03458 698973004898 UPF0126 domain; Region: UPF0126; pfam03458 698973004899 DNA primase; Validated; Region: dnaG; PRK05667 698973004900 CHC2 zinc finger; Region: zf-CHC2; pfam01807 698973004901 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 698973004902 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 698973004903 active site 698973004904 metal binding site [ion binding]; metal-binding site 698973004905 interdomain interaction site; other site 698973004906 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 698973004907 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 698973004908 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 698973004909 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 698973004910 glutaminase active site [active] 698973004911 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698973004912 dimer interface [polypeptide binding]; other site 698973004913 active site 698973004914 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 698973004915 dimer interface [polypeptide binding]; other site 698973004916 active site 698973004917 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 698973004918 active site 698973004919 barstar interaction site; other site 698973004920 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 698973004921 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698973004922 Zn2+ binding site [ion binding]; other site 698973004923 Mg2+ binding site [ion binding]; other site 698973004924 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 698973004925 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698973004926 putative active site [active] 698973004927 Repair protein; Region: Repair_PSII; pfam04536 698973004928 glycyl-tRNA synthetase; Provisional; Region: PRK04173 698973004929 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698973004930 motif 1; other site 698973004931 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 698973004932 active site 698973004933 motif 2; other site 698973004934 motif 3; other site 698973004935 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 698973004936 anticodon binding site; other site 698973004937 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698973004938 dimerization interface [polypeptide binding]; other site 698973004939 putative DNA binding site [nucleotide binding]; other site 698973004940 putative Zn2+ binding site [ion binding]; other site 698973004941 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698973004942 metal binding site 2 [ion binding]; metal-binding site 698973004943 putative DNA binding helix; other site 698973004944 metal binding site 1 [ion binding]; metal-binding site 698973004945 dimer interface [polypeptide binding]; other site 698973004946 structural Zn2+ binding site [ion binding]; other site 698973004947 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 698973004948 diiron binding motif [ion binding]; other site 698973004949 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 698973004950 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698973004951 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 698973004952 catalytic residue [active] 698973004953 putative FPP diphosphate binding site; other site 698973004954 putative FPP binding hydrophobic cleft; other site 698973004955 dimer interface [polypeptide binding]; other site 698973004956 putative IPP diphosphate binding site; other site 698973004957 Recombination protein O N terminal; Region: RecO_N; pfam11967 698973004958 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 698973004959 Recombination protein O C terminal; Region: RecO_C; pfam02565 698973004960 GTPase Era; Reviewed; Region: era; PRK00089 698973004961 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 698973004962 G1 box; other site 698973004963 GTP/Mg2+ binding site [chemical binding]; other site 698973004964 Switch I region; other site 698973004965 G2 box; other site 698973004966 Switch II region; other site 698973004967 G3 box; other site 698973004968 G4 box; other site 698973004969 G5 box; other site 698973004970 KH domain; Region: KH_2; pfam07650 698973004971 pyridoxamine kinase; Validated; Region: PRK05756 698973004972 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 698973004973 dimer interface [polypeptide binding]; other site 698973004974 pyridoxal binding site [chemical binding]; other site 698973004975 ATP binding site [chemical binding]; other site 698973004976 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698973004977 Domain of unknown function DUF21; Region: DUF21; pfam01595 698973004978 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698973004979 Transporter associated domain; Region: CorC_HlyC; smart01091 698973004980 metal-binding heat shock protein; Provisional; Region: PRK00016 698973004981 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 698973004982 PhoH-like protein; Region: PhoH; pfam02562 698973004983 RNA methyltransferase, RsmE family; Region: TIGR00046 698973004984 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 698973004985 chaperone protein DnaJ; Provisional; Region: PRK14278 698973004986 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698973004987 HSP70 interaction site [polypeptide binding]; other site 698973004988 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698973004989 Zn binding sites [ion binding]; other site 698973004990 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698973004991 dimer interface [polypeptide binding]; other site 698973004992 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 698973004993 coproporphyrinogen III oxidase; Validated; Region: PRK05628 698973004994 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698973004995 FeS/SAM binding site; other site 698973004996 HemN C-terminal domain; Region: HemN_C; pfam06969 698973004997 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 698973004998 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 698973004999 acyl-activating enzyme (AAE) consensus motif; other site 698973005000 putative AMP binding site [chemical binding]; other site 698973005001 putative active site [active] 698973005002 putative CoA binding site [chemical binding]; other site 698973005003 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 698973005004 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 698973005005 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 698973005006 active site 698973005007 Zn binding site [ion binding]; other site 698973005008 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698973005009 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698973005010 substrate binding pocket [chemical binding]; other site 698973005011 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 698973005012 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 698973005013 active site 698973005014 metal binding site [ion binding]; metal-binding site 698973005015 nudix motif; other site 698973005016 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698973005017 active site 698973005018 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698973005019 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698973005020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973005021 Walker A/P-loop; other site 698973005022 ATP binding site [chemical binding]; other site 698973005023 Q-loop/lid; other site 698973005024 ABC transporter signature motif; other site 698973005025 Walker B; other site 698973005026 D-loop; other site 698973005027 H-loop/switch region; other site 698973005028 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 698973005029 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698973005030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698973005031 homodimer interface [polypeptide binding]; other site 698973005032 catalytic residue [active] 698973005033 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 698973005034 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698973005035 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 698973005036 BCCT family transporter; Region: BCCT; pfam02028 698973005037 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698973005038 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 698973005039 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698973005040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698973005041 dimer interface [polypeptide binding]; other site 698973005042 conserved gate region; other site 698973005043 putative PBP binding loops; other site 698973005044 ABC-ATPase subunit interface; other site 698973005045 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698973005046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698973005047 dimer interface [polypeptide binding]; other site 698973005048 conserved gate region; other site 698973005049 putative PBP binding loops; other site 698973005050 ABC-ATPase subunit interface; other site 698973005051 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698973005052 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698973005053 Walker A/P-loop; other site 698973005054 ATP binding site [chemical binding]; other site 698973005055 Q-loop/lid; other site 698973005056 ABC transporter signature motif; other site 698973005057 Walker B; other site 698973005058 D-loop; other site 698973005059 H-loop/switch region; other site 698973005060 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698973005061 Walker A/P-loop; other site 698973005062 ATP binding site [chemical binding]; other site 698973005063 Q-loop/lid; other site 698973005064 ABC transporter signature motif; other site 698973005065 Walker B; other site 698973005066 D-loop; other site 698973005067 H-loop/switch region; other site 698973005068 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698973005069 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 698973005070 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 698973005071 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698973005072 catalytic residue [active] 698973005073 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698973005074 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698973005075 nucleotide binding site [chemical binding]; other site 698973005076 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 698973005077 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698973005078 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698973005079 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 698973005080 active site residue [active] 698973005081 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 698973005082 putative homodimer interface [polypeptide binding]; other site 698973005083 putative homotetramer interface [polypeptide binding]; other site 698973005084 putative allosteric switch controlling residues; other site 698973005085 putative metal binding site [ion binding]; other site 698973005086 putative homodimer-homodimer interface [polypeptide binding]; other site 698973005087 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 698973005088 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698973005089 TrkA-N domain; Region: TrkA_N; pfam02254 698973005090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973005091 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 698973005092 active site 698973005093 tetramer interface [polypeptide binding]; other site 698973005094 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698973005095 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 698973005096 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698973005097 Mrr N-terminal domain; Region: Mrr_N; pfam14338 698973005098 Restriction endonuclease; Region: Mrr_cat; pfam04471 698973005099 Abi-like protein; Region: Abi_2; pfam07751 698973005100 AAA ATPase domain; Region: AAA_16; pfam13191 698973005101 GTP-binding protein LepA; Provisional; Region: PRK05433 698973005102 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 698973005103 G1 box; other site 698973005104 putative GEF interaction site [polypeptide binding]; other site 698973005105 GTP/Mg2+ binding site [chemical binding]; other site 698973005106 Switch I region; other site 698973005107 G2 box; other site 698973005108 G3 box; other site 698973005109 Switch II region; other site 698973005110 G4 box; other site 698973005111 G5 box; other site 698973005112 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 698973005113 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 698973005114 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 698973005115 PemK-like protein; Region: PemK; pfam02452 698973005116 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 698973005117 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698973005118 hypothetical protein; Validated; Region: PRK05629 698973005119 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 698973005120 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 698973005121 Competence protein; Region: Competence; pfam03772 698973005122 comEA protein; Region: comE; TIGR01259 698973005123 Helix-hairpin-helix motif; Region: HHH; pfam00633 698973005124 helix-hairpin-helix signature motif; other site 698973005125 EDD domain protein, DegV family; Region: DegV; TIGR00762 698973005126 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 698973005127 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698973005128 catalytic core [active] 698973005129 Oligomerisation domain; Region: Oligomerisation; cl00519 698973005130 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 698973005131 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 698973005132 active site 698973005133 (T/H)XGH motif; other site 698973005134 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 698973005135 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 698973005136 putative catalytic cysteine [active] 698973005137 gamma-glutamyl kinase; Provisional; Region: PRK05429 698973005138 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 698973005139 nucleotide binding site [chemical binding]; other site 698973005140 homotetrameric interface [polypeptide binding]; other site 698973005141 putative phosphate binding site [ion binding]; other site 698973005142 putative allosteric binding site; other site 698973005143 PUA domain; Region: PUA; pfam01472 698973005144 GTPase CgtA; Reviewed; Region: obgE; PRK12296 698973005145 GTP1/OBG; Region: GTP1_OBG; pfam01018 698973005146 Obg GTPase; Region: Obg; cd01898 698973005147 G1 box; other site 698973005148 GTP/Mg2+ binding site [chemical binding]; other site 698973005149 Switch I region; other site 698973005150 G2 box; other site 698973005151 G3 box; other site 698973005152 Switch II region; other site 698973005153 G4 box; other site 698973005154 G5 box; other site 698973005155 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 698973005156 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 698973005157 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 698973005158 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 698973005159 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698973005160 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 698973005161 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 698973005162 homodimer interface [polypeptide binding]; other site 698973005163 oligonucleotide binding site [chemical binding]; other site 698973005164 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 698973005165 active site 698973005166 multimer interface [polypeptide binding]; other site 698973005167 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 698973005168 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 698973005169 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698973005170 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 698973005171 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698973005172 active site 698973005173 HIGH motif; other site 698973005174 nucleotide binding site [chemical binding]; other site 698973005175 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698973005176 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 698973005177 active site 698973005178 KMSKS motif; other site 698973005179 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 698973005180 tRNA binding surface [nucleotide binding]; other site 698973005181 anticodon binding site; other site 698973005182 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 698973005183 malate dehydrogenase; Provisional; Region: PRK05442 698973005184 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 698973005185 NAD(P) binding site [chemical binding]; other site 698973005186 dimer interface [polypeptide binding]; other site 698973005187 malate binding site [chemical binding]; other site 698973005188 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698973005189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698973005190 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 698973005191 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 698973005192 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 698973005193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698973005194 Walker A motif; other site 698973005195 ATP binding site [chemical binding]; other site 698973005196 Walker B motif; other site 698973005197 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 698973005198 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698973005199 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698973005200 glutamine binding [chemical binding]; other site 698973005201 catalytic triad [active] 698973005202 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 698973005203 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698973005204 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 698973005205 substrate-cofactor binding pocket; other site 698973005206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698973005207 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 698973005208 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698973005209 oligomer interface [polypeptide binding]; other site 698973005210 active site residues [active] 698973005211 Clp protease; Region: CLP_protease; pfam00574 698973005212 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698973005213 oligomer interface [polypeptide binding]; other site 698973005214 active site residues [active] 698973005215 trigger factor; Provisional; Region: tig; PRK01490 698973005216 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698973005217 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 698973005218 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 698973005219 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698973005220 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698973005221 catalytic residues [active] 698973005222 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 698973005223 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 698973005224 Zn binding site [ion binding]; other site 698973005225 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698973005226 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698973005227 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698973005228 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 698973005229 apolar tunnel; other site 698973005230 heme binding site [chemical binding]; other site 698973005231 dimerization interface [polypeptide binding]; other site 698973005232 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698973005233 active site 698973005234 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 698973005235 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973005236 Walker A/P-loop; other site 698973005237 ATP binding site [chemical binding]; other site 698973005238 Q-loop/lid; other site 698973005239 ABC transporter signature motif; other site 698973005240 Walker B; other site 698973005241 D-loop; other site 698973005242 H-loop/switch region; other site 698973005243 ABC transporter; Region: ABC_tran_2; pfam12848 698973005244 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698973005245 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698973005246 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698973005247 dimer interface [polypeptide binding]; other site 698973005248 ssDNA binding site [nucleotide binding]; other site 698973005249 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698973005250 Copper resistance protein D; Region: CopD; pfam05425 698973005251 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 698973005252 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 698973005253 Carbon starvation protein CstA; Region: CstA; pfam02554 698973005254 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 698973005255 Protein of unknown function (DUF466); Region: DUF466; pfam04328 698973005256 potential frameshift: common BLAST hit: gi|62389835|ref|YP_225237.1| major facilitator superfamily permease 698973005257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 698973005258 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698973005259 putative substrate translocation pore; other site 698973005260 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 698973005261 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 698973005262 NADP binding site [chemical binding]; other site 698973005263 dimer interface [polypeptide binding]; other site 698973005264 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698973005265 classical (c) SDRs; Region: SDR_c; cd05233 698973005266 NAD(P) binding site [chemical binding]; other site 698973005267 active site 698973005268 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 698973005269 catalytic site [active] 698973005270 putative active site [active] 698973005271 putative substrate binding site [chemical binding]; other site 698973005272 dimer interface [polypeptide binding]; other site 698973005273 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698973005274 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698973005275 inhibitor site; inhibition site 698973005276 active site 698973005277 dimer interface [polypeptide binding]; other site 698973005278 catalytic residue [active] 698973005279 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 698973005280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698973005281 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 698973005282 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698973005283 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698973005284 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 698973005285 active site 698973005286 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 698973005287 Phage-related protein [Function unknown]; Region: COG4695; cl01923 698973005288 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 698973005289 putative active site [active] 698973005290 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 698973005291 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 698973005292 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698973005293 active site 698973005294 DNA binding site [nucleotide binding] 698973005295 Int/Topo IB signature motif; other site 698973005296 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698973005297 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698973005298 HTH-like domain; Region: HTH_21; pfam13276 698973005299 Integrase core domain; Region: rve; pfam00665 698973005300 Integrase core domain; Region: rve_2; pfam13333 698973005301 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 698973005302 conserved cis-peptide bond; other site 698973005303 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 698973005304 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 698973005305 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698973005306 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 698973005307 catalytic triad [active] 698973005308 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698973005309 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698973005310 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 698973005311 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698973005312 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 698973005313 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698973005314 phosphate binding site [ion binding]; other site 698973005315 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 698973005316 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 698973005317 active site 2 [active] 698973005318 active site 1 [active] 698973005319 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 698973005320 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698973005321 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 698973005322 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 698973005323 putative NAD(P) binding site [chemical binding]; other site 698973005324 active site 698973005325 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 698973005326 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 698973005327 active site 698973005328 Glucitol operon activator protein (GutM); Region: GutM; cl01890 698973005329 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 698973005330 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 698973005331 active site 698973005332 dimerization interface [polypeptide binding]; other site 698973005333 ribonuclease PH; Reviewed; Region: rph; PRK00173 698973005334 Ribonuclease PH; Region: RNase_PH_bact; cd11362 698973005335 hexamer interface [polypeptide binding]; other site 698973005336 active site 698973005337 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 698973005338 glutamate racemase; Provisional; Region: PRK00865 698973005339 Rhomboid family; Region: Rhomboid; cl11446 698973005340 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 698973005341 putative active site pocket [active] 698973005342 cleavage site 698973005343 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 698973005344 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 698973005345 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 698973005346 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 698973005347 active site 698973005348 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 698973005349 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698973005350 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698973005351 putative Mg++ binding site [ion binding]; other site 698973005352 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 698973005353 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698973005354 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698973005355 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698973005356 active site 698973005357 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 698973005358 dimer interface [polypeptide binding]; other site 698973005359 putative active site [active] 698973005360 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 698973005361 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 698973005362 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 698973005363 phosphoserine phosphatase SerB; Region: serB; TIGR00338 698973005364 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698973005365 motif II; other site 698973005366 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 698973005367 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 698973005368 D-pathway; other site 698973005369 Putative ubiquinol binding site [chemical binding]; other site 698973005370 Low-spin heme (heme b) binding site [chemical binding]; other site 698973005371 Putative water exit pathway; other site 698973005372 Binuclear center (heme o3/CuB) [ion binding]; other site 698973005373 K-pathway; other site 698973005374 Putative proton exit pathway; other site 698973005375 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698973005376 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698973005377 dimer interface [polypeptide binding]; other site 698973005378 putative radical transfer pathway; other site 698973005379 diiron center [ion binding]; other site 698973005380 tyrosyl radical; other site 698973005381 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 698973005382 Ferritin-like domain; Region: Ferritin; pfam00210 698973005383 ferroxidase diiron center [ion binding]; other site 698973005384 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 698973005385 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 698973005386 Class I ribonucleotide reductase; Region: RNR_I; cd01679 698973005387 active site 698973005388 dimer interface [polypeptide binding]; other site 698973005389 catalytic residues [active] 698973005390 effector binding site; other site 698973005391 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698973005392 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698973005393 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698973005394 catalytic residues [active] 698973005395 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 698973005396 active site lid residues [active] 698973005397 substrate binding pocket [chemical binding]; other site 698973005398 catalytic residues [active] 698973005399 substrate-Mg2+ binding site; other site 698973005400 aspartate-rich region 1; other site 698973005401 aspartate-rich region 2; other site 698973005402 phytoene desaturase; Region: crtI_fam; TIGR02734 698973005403 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698973005404 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 698973005405 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 698973005406 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 698973005407 homodimer interface [polypeptide binding]; other site 698973005408 NAD binding pocket [chemical binding]; other site 698973005409 ATP binding pocket [chemical binding]; other site 698973005410 Mg binding site [ion binding]; other site 698973005411 active-site loop [active] 698973005412 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 698973005413 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698973005414 metal ion-dependent adhesion site (MIDAS); other site 698973005415 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 698973005416 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698973005417 catalytic residues [active] 698973005418 Methylamine utilisation protein MauE; Region: MauE; pfam07291 698973005419 phosphoglucomutase; Validated; Region: PRK07564 698973005420 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 698973005421 active site 698973005422 substrate binding site [chemical binding]; other site 698973005423 metal binding site [ion binding]; metal-binding site 698973005424 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134 698973005425 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698973005426 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698973005427 FtsX-like permease family; Region: FtsX; pfam02687 698973005428 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698973005429 FtsX-like permease family; Region: FtsX; pfam02687 698973005430 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698973005431 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698973005432 Walker A/P-loop; other site 698973005433 ATP binding site [chemical binding]; other site 698973005434 Q-loop/lid; other site 698973005435 ABC transporter signature motif; other site 698973005436 Walker B; other site 698973005437 D-loop; other site 698973005438 H-loop/switch region; other site 698973005439 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698973005440 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698973005441 hinge; other site 698973005442 active site 698973005443 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 698973005444 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 698973005445 GAF domain; Region: GAF_2; pfam13185 698973005446 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698973005447 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698973005448 DNA binding residues [nucleotide binding] 698973005449 dimerization interface [polypeptide binding]; other site 698973005450 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698973005451 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698973005452 dimer interface [polypeptide binding]; other site 698973005453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698973005454 catalytic residue [active] 698973005455 serine O-acetyltransferase; Region: cysE; TIGR01172 698973005456 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 698973005457 trimer interface [polypeptide binding]; other site 698973005458 active site 698973005459 substrate binding site [chemical binding]; other site 698973005460 CoA binding site [chemical binding]; other site 698973005461 Predicted acetyltransferase [General function prediction only]; Region: COG2388 698973005462 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 698973005463 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 698973005464 putative active site [active] 698973005465 metal binding site [ion binding]; metal-binding site 698973005466 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 698973005467 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698973005468 Walker A/P-loop; other site 698973005469 ATP binding site [chemical binding]; other site 698973005470 Q-loop/lid; other site 698973005471 ABC transporter signature motif; other site 698973005472 Walker B; other site 698973005473 D-loop; other site 698973005474 H-loop/switch region; other site 698973005475 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 698973005476 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698973005477 intersubunit interface [polypeptide binding]; other site 698973005478 potential frameshift: common BLAST hit: gi|337289952|ref|YP_004628973.1| zinc ABC transporter permease 698973005479 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698973005480 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698973005481 dimer interface [polypeptide binding]; other site 698973005482 putative PBP binding regions; other site 698973005483 ABC-ATPase subunit interface; other site 698973005484 ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism]; Region: FepD; COG0609 698973005485 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698973005486 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 698973005487 DNA methylase; Region: N6_N4_Mtase; pfam01555 698973005488 DNA methylase; Region: N6_N4_Mtase; pfam01555 698973005489 potential frameshift: common BLAST hit: gi|38232684|ref|NP_938451.1| transposase 698973005490 Transposase [DNA replication, recombination, and repair]; Region: COG5421 698973005491 potential frameshift: common BLAST hit: gi|38232684|ref|NP_938451.1| transposase 698973005492 Transposase [DNA replication, recombination, and repair]; Region: COG5421 698973005493 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698973005494 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698973005495 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698973005496 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698973005497 Integrase core domain; Region: rve; pfam00665 698973005498 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698973005499 Integrase core domain; Region: rve; pfam00665 698973005500 Integrase core domain; Region: rve_3; pfam13683 698973005501 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698973005502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698973005503 HTH-like domain; Region: HTH_21; pfam13276 698973005504 Integrase core domain; Region: rve; pfam00665 698973005505 Integrase core domain; Region: rve_2; pfam13333 698973005506 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 698973005507 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 698973005508 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698973005509 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698973005510 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 698973005511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973005512 Walker A/P-loop; other site 698973005513 ATP binding site [chemical binding]; other site 698973005514 Q-loop/lid; other site 698973005515 ABC transporter signature motif; other site 698973005516 Walker B; other site 698973005517 D-loop; other site 698973005518 H-loop/switch region; other site 698973005519 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 698973005520 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973005521 Walker A/P-loop; other site 698973005522 ATP binding site [chemical binding]; other site 698973005523 Q-loop/lid; other site 698973005524 ABC transporter signature motif; other site 698973005525 Walker B; other site 698973005526 D-loop; other site 698973005527 H-loop/switch region; other site 698973005528 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 698973005529 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 698973005530 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 698973005531 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 698973005532 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 698973005533 FMN binding site [chemical binding]; other site 698973005534 active site 698973005535 catalytic residues [active] 698973005536 substrate binding site [chemical binding]; other site 698973005537 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 698973005538 PhoU domain; Region: PhoU; pfam01895 698973005539 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 698973005540 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 698973005541 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698973005542 Coenzyme A binding pocket [chemical binding]; other site 698973005543 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698973005544 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698973005545 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 698973005546 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 698973005547 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 698973005548 heme-binding site [chemical binding]; other site 698973005549 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 698973005550 substrate binding site [chemical binding]; other site 698973005551 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 698973005552 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 698973005553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698973005554 catalytic residue [active] 698973005555 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 698973005556 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 698973005557 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698973005558 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 698973005559 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 698973005560 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 698973005561 dimerization interface [polypeptide binding]; other site 698973005562 putative ATP binding site [chemical binding]; other site 698973005563 amidophosphoribosyltransferase; Provisional; Region: PRK07847 698973005564 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 698973005565 active site 698973005566 tetramer interface [polypeptide binding]; other site 698973005567 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698973005568 active site 698973005569 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 698973005570 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 698973005571 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698973005572 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 698973005573 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698973005574 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698973005575 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698973005576 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698973005577 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698973005578 non-specific DNA binding site [nucleotide binding]; other site 698973005579 salt bridge; other site 698973005580 sequence-specific DNA binding site [nucleotide binding]; other site 698973005581 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698973005582 dimer interface [polypeptide binding]; other site 698973005583 diiron center [ion binding]; other site 698973005584 putative radical transfer pathway; other site 698973005585 tyrosyl radical; other site 698973005586 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 698973005587 catalytic residues [active] 698973005588 dimer interface [polypeptide binding]; other site 698973005589 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 698973005590 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698973005591 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 698973005592 ATP binding site [chemical binding]; other site 698973005593 active site 698973005594 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 698973005595 substrate binding site [chemical binding]; other site 698973005596 adenylosuccinate lyase; Region: purB; TIGR00928 698973005597 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 698973005598 tetramer interface [polypeptide binding]; other site 698973005599 aspartate aminotransferase; Provisional; Region: PRK05764 698973005600 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698973005601 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698973005602 homodimer interface [polypeptide binding]; other site 698973005603 catalytic residue [active] 698973005604 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 698973005605 TrkA-N domain; Region: TrkA_N; pfam02254 698973005606 TrkA-C domain; Region: TrkA_C; pfam02080 698973005607 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 698973005608 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 698973005609 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 698973005610 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 698973005611 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 698973005612 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 698973005613 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 698973005614 nucleotide binding site/active site [active] 698973005615 HIT family signature motif; other site 698973005616 catalytic residue [active] 698973005617 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 698973005618 PGAP1-like protein; Region: PGAP1; pfam07819 698973005619 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698973005620 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698973005621 dimerization interface [polypeptide binding]; other site 698973005622 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698973005623 dimer interface [polypeptide binding]; other site 698973005624 phosphorylation site [posttranslational modification] 698973005625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698973005626 ATP binding site [chemical binding]; other site 698973005627 Mg2+ binding site [ion binding]; other site 698973005628 G-X-G motif; other site 698973005629 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698973005630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698973005631 active site 698973005632 phosphorylation site [posttranslational modification] 698973005633 intermolecular recognition site; other site 698973005634 dimerization interface [polypeptide binding]; other site 698973005635 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698973005636 DNA binding site [nucleotide binding] 698973005637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973005638 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698973005639 putative substrate translocation pore; other site 698973005640 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698973005641 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698973005642 xanthine permease; Region: pbuX; TIGR03173 698973005643 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 698973005644 pyruvate dehydrogenase; Provisional; Region: PRK06546 698973005645 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 698973005646 PYR/PP interface [polypeptide binding]; other site 698973005647 dimer interface [polypeptide binding]; other site 698973005648 tetramer interface [polypeptide binding]; other site 698973005649 TPP binding site [chemical binding]; other site 698973005650 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698973005651 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 698973005652 TPP-binding site [chemical binding]; other site 698973005653 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698973005654 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 698973005655 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698973005656 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698973005657 Uncharacterized conserved protein [Function unknown]; Region: COG3610 698973005658 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 698973005659 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 698973005660 active site 698973005661 homotetramer interface [polypeptide binding]; other site 698973005662 META domain; Region: META; cl01245 698973005663 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 698973005664 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 698973005665 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698973005666 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698973005667 DNA binding site [nucleotide binding] 698973005668 domain linker motif; other site 698973005669 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 698973005670 putative dimerization interface [polypeptide binding]; other site 698973005671 putative ligand binding site [chemical binding]; other site 698973005672 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698973005673 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 698973005674 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698973005675 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 698973005676 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698973005677 active site 698973005678 HIGH motif; other site 698973005679 nucleotide binding site [chemical binding]; other site 698973005680 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698973005681 KMSKS motif; other site 698973005682 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698973005683 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 698973005684 homotrimer interaction site [polypeptide binding]; other site 698973005685 zinc binding site [ion binding]; other site 698973005686 CDP-binding sites; other site 698973005687 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 698973005688 substrate binding site; other site 698973005689 dimer interface; other site 698973005690 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 698973005691 DNA repair protein RadA; Provisional; Region: PRK11823 698973005692 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698973005693 Walker A motif; other site 698973005694 ATP binding site [chemical binding]; other site 698973005695 Walker B motif; other site 698973005696 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698973005697 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 698973005698 active site clefts [active] 698973005699 zinc binding site [ion binding]; other site 698973005700 dimer interface [polypeptide binding]; other site 698973005701 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698973005702 endonuclease III; Region: ENDO3c; smart00478 698973005703 minor groove reading motif; other site 698973005704 helix-hairpin-helix signature motif; other site 698973005705 substrate binding pocket [chemical binding]; other site 698973005706 active site 698973005707 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698973005708 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698973005709 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 698973005710 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 698973005711 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 698973005712 Clp amino terminal domain; Region: Clp_N; pfam02861 698973005713 Clp amino terminal domain; Region: Clp_N; pfam02861 698973005714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698973005715 Walker A motif; other site 698973005716 ATP binding site [chemical binding]; other site 698973005717 Walker B motif; other site 698973005718 arginine finger; other site 698973005719 UvrB/uvrC motif; Region: UVR; pfam02151 698973005720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698973005721 Walker A motif; other site 698973005722 ATP binding site [chemical binding]; other site 698973005723 Walker B motif; other site 698973005724 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698973005725 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 698973005726 oligomer interface [polypeptide binding]; other site 698973005727 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698973005728 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698973005729 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 698973005730 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698973005731 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698973005732 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 698973005733 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 698973005734 active site 698973005735 catalytic motif [active] 698973005736 Zn binding site [ion binding]; other site 698973005737 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 698973005738 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 698973005739 Nucleoside recognition; Region: Gate; pfam07670 698973005740 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 698973005741 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 698973005742 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698973005743 dimer interface [polypeptide binding]; other site 698973005744 putative anticodon binding site; other site 698973005745 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698973005746 motif 1; other site 698973005747 dimer interface [polypeptide binding]; other site 698973005748 active site 698973005749 motif 2; other site 698973005750 motif 3; other site 698973005751 uncharacterized domain; Region: TIGR00702 698973005752 YcaO-like family; Region: YcaO; pfam02624 698973005753 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 698973005754 NADPH bind site [chemical binding]; other site 698973005755 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 698973005756 dimer interface [polypeptide binding]; other site 698973005757 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 698973005758 SpaB C-terminal domain; Region: SpaB_C; pfam14028 698973005759 YcaO-like family; Region: YcaO; pfam02624 698973005760 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 698973005761 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698973005762 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698973005763 Walker A/P-loop; other site 698973005764 ATP binding site [chemical binding]; other site 698973005765 Q-loop/lid; other site 698973005766 ABC transporter signature motif; other site 698973005767 Walker B; other site 698973005768 D-loop; other site 698973005769 H-loop/switch region; other site 698973005770 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698973005771 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 698973005772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 698973005773 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698973005774 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698973005775 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698973005776 active site 698973005777 KMSKS motif; other site 698973005778 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 698973005779 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 698973005780 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 698973005781 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 698973005782 catalytic center binding site [active] 698973005783 ATP binding site [chemical binding]; other site 698973005784 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 698973005785 homooctamer interface [polypeptide binding]; other site 698973005786 active site 698973005787 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698973005788 dihydropteroate synthase; Region: DHPS; TIGR01496 698973005789 substrate binding pocket [chemical binding]; other site 698973005790 dimer interface [polypeptide binding]; other site 698973005791 inhibitor binding site; inhibition site 698973005792 Protein of unknown function, DUF393; Region: DUF393; pfam04134 698973005793 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 698973005794 homodecamer interface [polypeptide binding]; other site 698973005795 GTP cyclohydrolase I; Provisional; Region: PLN03044 698973005796 active site 698973005797 putative catalytic site residues [active] 698973005798 zinc binding site [ion binding]; other site 698973005799 GTP-CH-I/GFRP interaction surface; other site 698973005800 FtsH Extracellular; Region: FtsH_ext; pfam06480 698973005801 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 698973005802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698973005803 Walker A motif; other site 698973005804 ATP binding site [chemical binding]; other site 698973005805 Walker B motif; other site 698973005806 arginine finger; other site 698973005807 Peptidase family M41; Region: Peptidase_M41; pfam01434 698973005808 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698973005809 active site 698973005810 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 698973005811 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 698973005812 Ligand Binding Site [chemical binding]; other site 698973005813 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 698973005814 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 698973005815 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 698973005816 dimer interface [polypeptide binding]; other site 698973005817 substrate binding site [chemical binding]; other site 698973005818 metal binding sites [ion binding]; metal-binding site 698973005819 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698973005820 active site residue [active] 698973005821 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698973005822 MarR family; Region: MarR_2; pfam12802 698973005823 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698973005824 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 698973005825 acyl-activating enzyme (AAE) consensus motif; other site 698973005826 AMP binding site [chemical binding]; other site 698973005827 active site 698973005828 CoA binding site [chemical binding]; other site 698973005829 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698973005830 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 698973005831 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698973005832 putative trimer interface [polypeptide binding]; other site 698973005833 putative CoA binding site [chemical binding]; other site 698973005834 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698973005835 putative trimer interface [polypeptide binding]; other site 698973005836 putative CoA binding site [chemical binding]; other site 698973005837 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698973005838 metal ion-dependent adhesion site (MIDAS); other site 698973005839 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698973005840 active site 698973005841 catalytic site [active] 698973005842 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698973005843 potential frameshift: common BLAST hit: gi|38234579|ref|NP_940346.1| exported lipase 698973005844 Secretory lipase; Region: LIP; pfam03583 698973005845 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698973005846 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 698973005847 active site 698973005848 catalytic triad [active] 698973005849 oxyanion hole [active] 698973005850 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698973005851 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698973005852 ring oligomerisation interface [polypeptide binding]; other site 698973005853 ATP/Mg binding site [chemical binding]; other site 698973005854 stacking interactions; other site 698973005855 hinge regions; other site 698973005856 Integrase core domain; Region: rve_3; cl15866 698973005857 MULE transposase domain; Region: MULE; pfam10551 698973005858 hypothetical protein; Provisional; Region: PRK07907 698973005859 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 698973005860 active site 698973005861 metal binding site [ion binding]; metal-binding site 698973005862 dimer interface [polypeptide binding]; other site 698973005863 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698973005864 carboxylate-amine ligase; Provisional; Region: PRK13517 698973005865 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 698973005866 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698973005867 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698973005868 active site 698973005869 catalytic residues [active] 698973005870 metal binding site [ion binding]; metal-binding site 698973005871 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698973005872 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698973005873 Coenzyme A binding pocket [chemical binding]; other site 698973005874 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698973005875 putative catalytic site [active] 698973005876 putative metal binding site [ion binding]; other site 698973005877 putative phosphate binding site [ion binding]; other site 698973005878 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 698973005879 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 698973005880 putative active site [active] 698973005881 catalytic site [active] 698973005882 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 698973005883 putative active site [active] 698973005884 catalytic site [active] 698973005885 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698973005886 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698973005887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973005888 Walker A/P-loop; other site 698973005889 ATP binding site [chemical binding]; other site 698973005890 Q-loop/lid; other site 698973005891 ABC transporter signature motif; other site 698973005892 Walker B; other site 698973005893 D-loop; other site 698973005894 H-loop/switch region; other site 698973005895 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698973005896 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698973005897 substrate binding pocket [chemical binding]; other site 698973005898 membrane-bound complex binding site; other site 698973005899 hinge residues; other site 698973005900 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698973005901 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698973005902 active site 698973005903 ATP binding site [chemical binding]; other site 698973005904 substrate binding site [chemical binding]; other site 698973005905 activation loop (A-loop); other site 698973005906 propionate/acetate kinase; Provisional; Region: PRK12379 698973005907 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 698973005908 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 698973005909 ferredoxin-NADP+ reductase; Region: PLN02852 698973005910 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698973005911 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698973005912 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 698973005913 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698973005914 active site 698973005915 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698973005916 putative active site [active] 698973005917 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 698973005918 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698973005919 non-specific DNA binding site [nucleotide binding]; other site 698973005920 salt bridge; other site 698973005921 sequence-specific DNA binding site [nucleotide binding]; other site 698973005922 Integrase core domain; Region: rve; pfam00665 698973005923 Integrase core domain; Region: rve_2; pfam13333 698973005924 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 698973005925 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 698973005926 GDP-binding site [chemical binding]; other site 698973005927 ACT binding site; other site 698973005928 IMP binding site; other site 698973005929 Predicted membrane protein [Function unknown]; Region: COG4129 698973005930 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698973005931 chromosome segregation protein; Provisional; Region: PRK03918 698973005932 Predicted membrane protein [Function unknown]; Region: COG4129 698973005933 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698973005934 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 698973005935 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 698973005936 Integrase core domain; Region: rve; pfam00665 698973005937 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 698973005938 catalytic nucleophile [active] 698973005939 Abi-like protein; Region: Abi_2; cl01988 698973005940 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698973005941 putative transporter; Provisional; Region: PRK09821 698973005942 GntP family permease; Region: GntP_permease; pfam02447 698973005943 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698973005944 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698973005945 NAD(P) binding site [chemical binding]; other site 698973005946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 698973005947 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698973005948 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698973005949 DNA-binding site [nucleotide binding]; DNA binding site 698973005950 FCD domain; Region: FCD; pfam07729 698973005951 Cna protein B-type domain; Region: Cna_B; pfam05738 698973005952 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 698973005953 TQXA domain; Region: TQXA_dom; TIGR03934 698973005954 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 698973005955 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 698973005956 active site 698973005957 intersubunit interface [polypeptide binding]; other site 698973005958 zinc binding site [ion binding]; other site 698973005959 Na+ binding site [ion binding]; other site 698973005960 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 698973005961 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698973005962 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698973005963 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698973005964 active site 698973005965 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698973005966 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698973005967 active site residue [active] 698973005968 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698973005969 active site residue [active] 698973005970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698973005971 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 698973005972 Clp amino terminal domain; Region: Clp_N; pfam02861 698973005973 Clp amino terminal domain; Region: Clp_N; pfam02861 698973005974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698973005975 Walker A motif; other site 698973005976 ATP binding site [chemical binding]; other site 698973005977 Walker B motif; other site 698973005978 arginine finger; other site 698973005979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698973005980 Walker A motif; other site 698973005981 ATP binding site [chemical binding]; other site 698973005982 Walker B motif; other site 698973005983 arginine finger; other site 698973005984 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698973005985 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698973005986 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 698973005987 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698973005988 Walker A/P-loop; other site 698973005989 ATP binding site [chemical binding]; other site 698973005990 Q-loop/lid; other site 698973005991 ABC transporter signature motif; other site 698973005992 Walker B; other site 698973005993 D-loop; other site 698973005994 H-loop/switch region; other site 698973005995 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698973005996 EamA-like transporter family; Region: EamA; pfam00892 698973005997 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698973005998 EamA-like transporter family; Region: EamA; pfam00892 698973005999 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 698973006000 FAD binding pocket [chemical binding]; other site 698973006001 FAD binding motif [chemical binding]; other site 698973006002 phosphate binding motif [ion binding]; other site 698973006003 beta-alpha-beta structure motif; other site 698973006004 NAD binding pocket [chemical binding]; other site 698973006005 Predicted amidohydrolase [General function prediction only]; Region: COG0388 698973006006 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 698973006007 putative active site [active] 698973006008 catalytic triad [active] 698973006009 putative dimer interface [polypeptide binding]; other site 698973006010 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 698973006011 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 698973006012 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 698973006013 NAD binding site [chemical binding]; other site 698973006014 substrate binding site [chemical binding]; other site 698973006015 catalytic Zn binding site [ion binding]; other site 698973006016 tetramer interface [polypeptide binding]; other site 698973006017 structural Zn binding site [ion binding]; other site 698973006018 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698973006019 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698973006020 NAD(P) binding site [chemical binding]; other site 698973006021 catalytic residues [active] 698973006022 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 698973006023 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 698973006024 DNA binding residues [nucleotide binding] 698973006025 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698973006026 putative dimer interface [polypeptide binding]; other site 698973006027 chaperone protein DnaJ; Provisional; Region: PRK14279 698973006028 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698973006029 HSP70 interaction site [polypeptide binding]; other site 698973006030 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698973006031 Zn binding sites [ion binding]; other site 698973006032 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698973006033 dimer interface [polypeptide binding]; other site 698973006034 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 698973006035 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 698973006036 dimer interface [polypeptide binding]; other site 698973006037 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 698973006038 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 698973006039 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 698973006040 nucleotide binding site [chemical binding]; other site 698973006041 NEF interaction site [polypeptide binding]; other site 698973006042 SBD interface [polypeptide binding]; other site 698973006043 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698973006044 PAS domain; Region: PAS_9; pfam13426 698973006045 putative active site [active] 698973006046 heme pocket [chemical binding]; other site 698973006047 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698973006048 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698973006049 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698973006050 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698973006051 Walker A/P-loop; other site 698973006052 ATP binding site [chemical binding]; other site 698973006053 Q-loop/lid; other site 698973006054 ABC transporter signature motif; other site 698973006055 Walker B; other site 698973006056 D-loop; other site 698973006057 H-loop/switch region; other site 698973006058 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698973006059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698973006060 dimer interface [polypeptide binding]; other site 698973006061 conserved gate region; other site 698973006062 putative PBP binding loops; other site 698973006063 ABC-ATPase subunit interface; other site 698973006064 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698973006065 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 698973006066 Walker A/P-loop; other site 698973006067 ATP binding site [chemical binding]; other site 698973006068 Q-loop/lid; other site 698973006069 ABC transporter signature motif; other site 698973006070 Walker B; other site 698973006071 D-loop; other site 698973006072 H-loop/switch region; other site 698973006073 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698973006074 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698973006075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698973006076 dimer interface [polypeptide binding]; other site 698973006077 conserved gate region; other site 698973006078 putative PBP binding loops; other site 698973006079 ABC-ATPase subunit interface; other site 698973006080 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698973006081 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 698973006082 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698973006083 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698973006084 ferredoxin-NADP+ reductase; Region: PLN02852 698973006085 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698973006086 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 698973006087 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 698973006088 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 698973006089 dimerization interface [polypeptide binding]; other site 698973006090 ATP binding site [chemical binding]; other site 698973006091 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 698973006092 dimerization interface [polypeptide binding]; other site 698973006093 ATP binding site [chemical binding]; other site 698973006094 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 698973006095 putative active site [active] 698973006096 catalytic triad [active] 698973006097 potential frameshift: common BLAST hit: gi|32479398|ref|NP_862251.1| Tnp1250a 698973006098 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698973006099 potential frameshift: common BLAST hit: gi|32479398|ref|NP_862251.1| Tnp1250a 698973006100 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698973006101 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698973006102 potential frameshift: common BLAST hit: gi|269958070|ref|YP_003327859.1| Integrase catalytic region 698973006103 Integrase core domain; Region: rve; pfam00665 698973006104 Integrase core domain; Region: rve; pfam00665 698973006105 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 698973006106 FAD binding pocket [chemical binding]; other site 698973006107 FAD binding motif [chemical binding]; other site 698973006108 phosphate binding motif [ion binding]; other site 698973006109 NAD binding pocket [chemical binding]; other site 698973006110 Siderophore-interacting protein; Region: SIP; pfam04954 698973006111 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698973006112 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698973006113 Walker A/P-loop; other site 698973006114 ATP binding site [chemical binding]; other site 698973006115 Q-loop/lid; other site 698973006116 ABC transporter signature motif; other site 698973006117 Walker B; other site 698973006118 D-loop; other site 698973006119 H-loop/switch region; other site 698973006120 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698973006121 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698973006122 ABC-ATPase subunit interface; other site 698973006123 dimer interface [polypeptide binding]; other site 698973006124 putative PBP binding regions; other site 698973006125 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698973006126 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698973006127 ABC-ATPase subunit interface; other site 698973006128 dimer interface [polypeptide binding]; other site 698973006129 putative PBP binding regions; other site 698973006130 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698973006131 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698973006132 siderophore binding site; other site 698973006133 nucleosidase; Provisional; Region: PRK05634 698973006134 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 698973006135 ferredoxin-NADP+ reductase; Region: PLN02852 698973006136 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698973006137 4Fe-4S binding domain; Region: Fer4; cl02805 698973006138 Cysteine-rich domain; Region: CCG; pfam02754 698973006139 Cysteine-rich domain; Region: CCG; pfam02754 698973006140 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 698973006141 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698973006142 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 698973006143 putative NAD(P) binding site [chemical binding]; other site 698973006144 catalytic Zn binding site [ion binding]; other site 698973006145 aminotransferase AlaT; Validated; Region: PRK09265 698973006146 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698973006147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698973006148 homodimer interface [polypeptide binding]; other site 698973006149 catalytic residue [active] 698973006150 YibE/F-like protein; Region: YibE_F; pfam07907 698973006151 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 698973006152 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 698973006153 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698973006154 dimer interface [polypeptide binding]; other site 698973006155 putative anticodon binding site; other site 698973006156 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698973006157 motif 1; other site 698973006158 dimer interface [polypeptide binding]; other site 698973006159 active site 698973006160 motif 2; other site 698973006161 motif 3; other site 698973006162 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698973006163 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698973006164 Protein of unknown function (DUF998); Region: DUF998; pfam06197 698973006165 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 698973006166 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 698973006167 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 698973006168 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698973006169 trimer interface [polypeptide binding]; other site 698973006170 active site 698973006171 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698973006172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973006173 Walker A/P-loop; other site 698973006174 ATP binding site [chemical binding]; other site 698973006175 Q-loop/lid; other site 698973006176 ABC transporter signature motif; other site 698973006177 Walker B; other site 698973006178 D-loop; other site 698973006179 H-loop/switch region; other site 698973006180 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 698973006181 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698973006182 active site 698973006183 potential frameshift: common BLAST hit: gi|38234699|ref|NP_940466.1| DNA-binding bacteriophage protein 698973006184 Prophage antirepressor [Transcription]; Region: COG3617 698973006185 BRO family, N-terminal domain; Region: Bro-N; smart01040 698973006186 Abi-like protein; Region: Abi_2; cl01988 698973006187 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 698973006188 Integrase core domain; Region: rve_3; cl15866 698973006189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973006190 ABC transporter signature motif; other site 698973006191 Walker B; other site 698973006192 D-loop; other site 698973006193 H-loop/switch region; other site 698973006194 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973006195 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 698973006196 Walker A/P-loop; other site 698973006197 ATP binding site [chemical binding]; other site 698973006198 Q-loop/lid; other site 698973006199 ABC transporter signature motif; other site 698973006200 Walker B; other site 698973006201 D-loop; other site 698973006202 H-loop/switch region; other site 698973006203 metabolite-proton symporter; Region: 2A0106; TIGR00883 698973006204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973006205 putative substrate translocation pore; other site 698973006206 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698973006207 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698973006208 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 698973006209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973006210 putative substrate translocation pore; other site 698973006211 YwiC-like protein; Region: YwiC; pfam14256 698973006212 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698973006213 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698973006214 VanW like protein; Region: VanW; pfam04294 698973006215 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 698973006216 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 698973006217 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 698973006218 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 698973006219 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698973006220 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698973006221 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698973006222 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698973006223 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698973006224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698973006225 S-adenosylmethionine binding site [chemical binding]; other site 698973006226 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 698973006227 active site 698973006228 substrate-binding site [chemical binding]; other site 698973006229 metal-binding site [ion binding] 698973006230 GTP binding site [chemical binding]; other site 698973006231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698973006232 S-adenosylmethionine binding site [chemical binding]; other site 698973006233 LabA_like proteins; Region: LabA_like; cd06167 698973006234 putative metal binding site [ion binding]; other site 698973006235 MMPL family; Region: MMPL; pfam03176 698973006236 Protein of unknown function (DUF496); Region: DUF496; cl09955 698973006237 MMPL family; Region: MMPL; pfam03176 698973006238 Predicted integral membrane protein [Function unknown]; Region: COG0392 698973006239 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 698973006240 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 698973006241 TQXA domain; Region: TQXA_dom; TIGR03934 698973006242 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 698973006243 active site 698973006244 potential frameshift: common BLAST hit: gi|38234729|ref|NP_940496.1| propionyl-CoA carboxylase subunit beta 698973006245 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698973006246 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698973006247 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698973006248 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698973006249 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698973006250 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 698973006251 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 698973006252 active site 698973006253 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 698973006254 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698973006255 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 698973006256 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 698973006257 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 698973006258 acyl-activating enzyme (AAE) consensus motif; other site 698973006259 active site 698973006260 Cutinase; Region: Cutinase; pfam01083 698973006261 Putative esterase; Region: Esterase; pfam00756 698973006262 S-formylglutathione hydrolase; Region: PLN02442 698973006263 LGFP repeat; Region: LGFP; pfam08310 698973006264 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698973006265 LGFP repeat; Region: LGFP; pfam08310 698973006266 LGFP repeat; Region: LGFP; pfam08310 698973006267 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698973006268 Predicted esterase [General function prediction only]; Region: COG0627 698973006269 S-formylglutathione hydrolase; Region: PLN02442 698973006270 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 698973006271 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 698973006272 UbiA prenyltransferase family; Region: UbiA; pfam01040 698973006273 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698973006274 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698973006275 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698973006276 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698973006277 active site 698973006278 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698973006279 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698973006280 NAD(P) binding site [chemical binding]; other site 698973006281 catalytic residues [active] 698973006282 BCCT family transporter; Region: BCCT; cl00569 698973006283 choline dehydrogenase; Validated; Region: PRK02106 698973006284 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698973006285 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 698973006286 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698973006287 UDP-galactopyranose mutase; Region: GLF; pfam03275 698973006288 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 698973006289 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 698973006290 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698973006291 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973006292 ABC transporter signature motif; other site 698973006293 Walker B; other site 698973006294 D-loop; other site 698973006295 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 698973006296 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698973006297 Resolvase, N terminal domain; Region: Resolvase; pfam00239 698973006298 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 698973006299 DNA-binding interface [nucleotide binding]; DNA binding site 698973006300 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698973006301 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698973006302 active site 698973006303 catalytic tetrad [active] 698973006304 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 698973006305 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 698973006306 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012 698973006307 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698973006308 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698973006309 active site 698973006310 catalytic tetrad [active] 698973006311 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698973006312 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698973006313 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 698973006314 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698973006315 Helix-turn-helix domain; Region: HTH_38; pfam13936 698973006316 Integrase core domain; Region: rve; pfam00665 698973006317 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698973006318 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 698973006319 putative substrate binding site [chemical binding]; other site 698973006320 putative ATP binding site [chemical binding]; other site 698973006321 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 698973006322 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 698973006323 substrate binding [chemical binding]; other site 698973006324 active site 698973006325 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 698973006326 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698973006327 active site turn [active] 698973006328 phosphorylation site [posttranslational modification] 698973006329 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698973006330 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 698973006331 HPr interaction site; other site 698973006332 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698973006333 active site 698973006334 phosphorylation site [posttranslational modification] 698973006335 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698973006336 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698973006337 amidase catalytic site [active] 698973006338 Zn binding residues [ion binding]; other site 698973006339 substrate binding site [chemical binding]; other site 698973006340 LGFP repeat; Region: LGFP; pfam08310 698973006341 Predicted ATPases [General function prediction only]; Region: COG1106 698973006342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973006343 Q-loop/lid; other site 698973006344 ABC transporter signature motif; other site 698973006345 Walker B; other site 698973006346 D-loop; other site 698973006347 H-loop/switch region; other site 698973006348 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698973006349 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 698973006350 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 698973006351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698973006352 HTH-like domain; Region: HTH_21; pfam13276 698973006353 Integrase core domain; Region: rve; pfam00665 698973006354 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698973006355 sequence-specific DNA binding site [nucleotide binding]; other site 698973006356 salt bridge; other site 698973006357 glycerol kinase; Provisional; Region: glpK; PRK00047 698973006358 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 698973006359 N- and C-terminal domain interface [polypeptide binding]; other site 698973006360 active site 698973006361 MgATP binding site [chemical binding]; other site 698973006362 catalytic site [active] 698973006363 metal binding site [ion binding]; metal-binding site 698973006364 putative homotetramer interface [polypeptide binding]; other site 698973006365 glycerol binding site [chemical binding]; other site 698973006366 homodimer interface [polypeptide binding]; other site 698973006367 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 698973006368 amphipathic channel; other site 698973006369 Asn-Pro-Ala signature motifs; other site 698973006370 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 698973006371 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698973006372 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698973006373 putative acyl-acceptor binding pocket; other site 698973006374 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698973006375 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698973006376 active site 698973006377 motif I; other site 698973006378 motif II; other site 698973006379 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698973006380 seryl-tRNA synthetase; Provisional; Region: PRK05431 698973006381 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 698973006382 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 698973006383 dimer interface [polypeptide binding]; other site 698973006384 active site 698973006385 motif 1; other site 698973006386 motif 2; other site 698973006387 motif 3; other site 698973006388 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698973006389 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698973006390 DNA-binding site [nucleotide binding]; DNA binding site 698973006391 UTRA domain; Region: UTRA; pfam07702 698973006392 Septum formation; Region: Septum_form; pfam13845 698973006393 Septum formation; Region: Septum_form; pfam13845 698973006394 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 698973006395 AAA domain; Region: AAA_14; pfam13173 698973006396 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 698973006397 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698973006398 catalytic core [active] 698973006399 prephenate dehydratase; Provisional; Region: PRK11898 698973006400 Prephenate dehydratase; Region: PDT; pfam00800 698973006401 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 698973006402 putative L-Phe binding site [chemical binding]; other site 698973006403 Amidase; Region: Amidase; cl11426 698973006404 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698973006405 CAAX protease self-immunity; Region: Abi; pfam02517 698973006406 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 698973006407 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698973006408 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698973006409 amino acid carrier protein; Region: agcS; TIGR00835 698973006410 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698973006411 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 698973006412 catalytic triad [active] 698973006413 catalytic triad [active] 698973006414 oxyanion hole [active] 698973006415 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698973006416 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 698973006417 putative active site [active] 698973006418 catalytic site [active] 698973006419 putative metal binding site [ion binding]; other site 698973006420 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 698973006421 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 698973006422 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698973006423 NAD binding site [chemical binding]; other site 698973006424 dimer interface [polypeptide binding]; other site 698973006425 substrate binding site [chemical binding]; other site 698973006426 potential frameshift: common BLAST hit: gi|68536879|ref|YP_251584.1| transposase IS3504i 698973006427 HTH-like domain; Region: HTH_21; pfam13276 698973006428 Integrase core domain; Region: rve; pfam00665 698973006429 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698973006430 Helix-turn-helix domain; Region: HTH_38; pfam13936 698973006431 Integrase core domain; Region: rve; pfam00665 698973006432 Integrase core domain; Region: rve_3; cl15866 698973006433 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 698973006434 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 698973006435 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 698973006436 Predicted flavoprotein [General function prediction only]; Region: COG0431 698973006437 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698973006438 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 698973006439 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 698973006440 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698973006441 Lsr2; Region: Lsr2; pfam11774 698973006442 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698973006443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698973006444 active site 698973006445 phosphorylation site [posttranslational modification] 698973006446 intermolecular recognition site; other site 698973006447 dimerization interface [polypeptide binding]; other site 698973006448 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698973006449 DNA binding residues [nucleotide binding] 698973006450 dimerization interface [polypeptide binding]; other site 698973006451 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698973006452 Histidine kinase; Region: HisKA_3; pfam07730 698973006453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698973006454 ATP binding site [chemical binding]; other site 698973006455 Mg2+ binding site [ion binding]; other site 698973006456 G-X-G motif; other site 698973006457 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 698973006458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973006459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973006460 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 698973006461 active site 698973006462 catalytic site [active] 698973006463 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 698973006464 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 698973006465 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698973006466 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698973006467 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698973006468 Ligand Binding Site [chemical binding]; other site 698973006469 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698973006470 Ligand Binding Site [chemical binding]; other site 698973006471 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 698973006472 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698973006473 probable active site [active] 698973006474 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698973006475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973006476 Walker A/P-loop; other site 698973006477 ATP binding site [chemical binding]; other site 698973006478 Q-loop/lid; other site 698973006479 ABC transporter signature motif; other site 698973006480 Walker B; other site 698973006481 D-loop; other site 698973006482 H-loop/switch region; other site 698973006483 Predicted transcriptional regulators [Transcription]; Region: COG1725 698973006484 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698973006485 DNA-binding site [nucleotide binding]; DNA binding site 698973006486 LabA_like proteins; Region: LabA_like; cd06167 698973006487 putative metal binding site [ion binding]; other site 698973006488 Uncharacterized conserved protein [Function unknown]; Region: COG1432 698973006489 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698973006490 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698973006491 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698973006492 catalytic residues [active] 698973006493 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698973006494 metal-binding site [ion binding] 698973006495 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698973006496 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698973006497 metal-binding site [ion binding] 698973006498 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698973006499 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698973006500 benzoate transport; Region: 2A0115; TIGR00895 698973006501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973006502 putative substrate translocation pore; other site 698973006503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698973006504 replicative DNA helicase; Provisional; Region: PRK05636 698973006505 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 698973006506 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 698973006507 Walker A motif; other site 698973006508 ATP binding site [chemical binding]; other site 698973006509 Walker B motif; other site 698973006510 DNA binding loops [nucleotide binding] 698973006511 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 698973006512 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 698973006513 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 698973006514 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698973006515 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698973006516 dimer interface [polypeptide binding]; other site 698973006517 ssDNA binding site [nucleotide binding]; other site 698973006518 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698973006519 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 698973006520 Predicted integral membrane protein [Function unknown]; Region: COG5650 698973006521 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698973006522 Transglycosylase; Region: Transgly; pfam00912 698973006523 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698973006524 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698973006525 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698973006526 Ligand Binding Site [chemical binding]; other site 698973006527 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698973006528 Ligand Binding Site [chemical binding]; other site 698973006529 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698973006530 classical (c) SDRs; Region: SDR_c; cd05233 698973006531 NAD(P) binding site [chemical binding]; other site 698973006532 active site 698973006533 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698973006534 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698973006535 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 698973006536 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 698973006537 active site residue [active] 698973006538 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 698973006539 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698973006540 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 698973006541 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 698973006542 dimerization interface [polypeptide binding]; other site 698973006543 DPS ferroxidase diiron center [ion binding]; other site 698973006544 ion pore; other site 698973006545 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 698973006546 putative DNA binding site [nucleotide binding]; other site 698973006547 catalytic residue [active] 698973006548 putative H2TH interface [polypeptide binding]; other site 698973006549 putative catalytic residues [active] 698973006550 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698973006551 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 698973006552 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 698973006553 Integrase core domain; Region: rve; pfam00665 698973006554 integrase/recombinase; Provisional; Region: PRK15417 698973006555 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 698973006556 Int/Topo IB signature motif; other site 698973006557 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698973006558 dihydropteroate synthase; Region: DHPS; TIGR01496 698973006559 substrate binding pocket [chemical binding]; other site 698973006560 dimer interface [polypeptide binding]; other site 698973006561 inhibitor binding site; inhibition site 698973006562 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 698973006563 DDE domain; Region: DDE_Tnp_IS240; pfam13610 698973006564 Integrase core domain; Region: rve; pfam00665 698973006565 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 698973006566 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 698973006567 putative substrate binding site [chemical binding]; other site 698973006568 putative ATP binding site [chemical binding]; other site 698973006569 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 698973006570 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 698973006571 active site 698973006572 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698973006573 AAA domain; Region: AAA_31; pfam13614 698973006574 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698973006575 P-loop; other site 698973006576 Magnesium ion binding site [ion binding]; other site 698973006577 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698973006578 Magnesium ion binding site [ion binding]; other site 698973006579 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 698973006580 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 698973006581 putative ligand binding residues [chemical binding]; other site 698973006582 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698973006583 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698973006584 ABC-ATPase subunit interface; other site 698973006585 dimer interface [polypeptide binding]; other site 698973006586 putative PBP binding regions; other site 698973006587 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698973006588 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698973006589 Walker A/P-loop; other site 698973006590 ATP binding site [chemical binding]; other site 698973006591 Q-loop/lid; other site 698973006592 ABC transporter signature motif; other site 698973006593 Walker B; other site 698973006594 D-loop; other site 698973006595 H-loop/switch region; other site 698973006596 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 698973006597 dimer interface [polypeptide binding]; other site 698973006598 [2Fe-2S] cluster binding site [ion binding]; other site 698973006599 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 698973006600 Protein of unknown function (DUF1509); Region: DUF1509; pfam07420 698973006601 Divergent AAA domain; Region: AAA_4; pfam04326 698973006602 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698973006603 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698973006604 Divergent AAA domain; Region: AAA_4; pfam04326 698973006605 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698973006606 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698973006607 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 698973006608 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698973006609 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698973006610 ATP binding site [chemical binding]; other site 698973006611 putative Mg++ binding site [ion binding]; other site 698973006612 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 698973006613 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 698973006614 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698973006615 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698973006616 HsdM N-terminal domain; Region: HsdM_N; pfam12161 698973006617 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 698973006618 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698973006619 Fic family protein [Function unknown]; Region: COG3177 698973006620 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698973006621 Fic/DOC family; Region: Fic; pfam02661 698973006622 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 698973006623 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 698973006624 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 698973006625 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 698973006626 E-class dimer interface [polypeptide binding]; other site 698973006627 P-class dimer interface [polypeptide binding]; other site 698973006628 active site 698973006629 Cu2+ binding site [ion binding]; other site 698973006630 Zn2+ binding site [ion binding]; other site 698973006631 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 698973006632 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698973006633 active site 698973006634 HIGH motif; other site 698973006635 nucleotide binding site [chemical binding]; other site 698973006636 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698973006637 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698973006638 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698973006639 active site 698973006640 KMSKS motif; other site 698973006641 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 698973006642 tRNA binding surface [nucleotide binding]; other site 698973006643 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698973006644 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698973006645 Walker A/P-loop; other site 698973006646 ATP binding site [chemical binding]; other site 698973006647 Q-loop/lid; other site 698973006648 ABC transporter signature motif; other site 698973006649 Walker B; other site 698973006650 D-loop; other site 698973006651 H-loop/switch region; other site 698973006652 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698973006653 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698973006654 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698973006655 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698973006656 Histidine kinase; Region: HisKA_3; pfam07730 698973006657 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698973006658 ATP binding site [chemical binding]; other site 698973006659 G-X-G motif; other site 698973006660 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698973006661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698973006662 active site 698973006663 phosphorylation site [posttranslational modification] 698973006664 intermolecular recognition site; other site 698973006665 dimerization interface [polypeptide binding]; other site 698973006666 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698973006667 DNA binding residues [nucleotide binding] 698973006668 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698973006669 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698973006670 Predicted membrane protein [Function unknown]; Region: COG1511 698973006671 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698973006672 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698973006673 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698973006674 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698973006675 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698973006676 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698973006677 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 698973006678 NAD(P) binding site [chemical binding]; other site 698973006679 catalytic residues [active] 698973006680 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698973006681 active site 698973006682 phosphorylation site [posttranslational modification] 698973006683 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 698973006684 active site 698973006685 P-loop; other site 698973006686 phosphorylation site [posttranslational modification] 698973006687 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 698973006688 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 698973006689 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 698973006690 DAK2 domain; Region: Dak2; cl03685 698973006691 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 698973006692 active site 698973006693 active pocket/dimerization site; other site 698973006694 phosphorylation site [posttranslational modification] 698973006695 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698973006696 dimerization domain swap beta strand [polypeptide binding]; other site 698973006697 regulatory protein interface [polypeptide binding]; other site 698973006698 active site 698973006699 regulatory phosphorylation site [posttranslational modification]; other site 698973006700 Predicted ATPases [General function prediction only]; Region: COG1106 698973006701 Putative esterase; Region: Esterase; pfam00756 698973006702 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 698973006703 active site 698973006704 Cobalt transport protein; Region: CbiQ; cl00463 698973006705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973006706 ABC transporter signature motif; other site 698973006707 Walker B; other site 698973006708 D-loop; other site 698973006709 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698973006710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698973006711 Walker A/P-loop; other site 698973006712 ATP binding site [chemical binding]; other site 698973006713 Q-loop/lid; other site 698973006714 ABC transporter signature motif; other site 698973006715 Walker B; other site 698973006716 D-loop; other site 698973006717 H-loop/switch region; other site 698973006718 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 698973006719 active site 698973006720 catalytic residues [active] 698973006721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 698973006722 hypothetical protein; Provisional; Region: PRK13663 698973006723 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698973006724 putative active site [active] 698973006725 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698973006726 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698973006727 SdpI/YhfL protein family; Region: SdpI; pfam13630 698973006728 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698973006729 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698973006730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698973006731 catalytic residue [active] 698973006732 anthranilate synthase component I; Provisional; Region: PRK13564 698973006733 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 698973006734 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698973006735 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698973006736 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698973006737 glutamine binding [chemical binding]; other site 698973006738 catalytic triad [active] 698973006739 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 698973006740 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698973006741 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698973006742 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 698973006743 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698973006744 active site 698973006745 ribulose/triose binding site [chemical binding]; other site 698973006746 phosphate binding site [ion binding]; other site 698973006747 substrate (anthranilate) binding pocket [chemical binding]; other site 698973006748 product (indole) binding pocket [chemical binding]; other site 698973006749 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 698973006750 active site 698973006751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 698973006752 pantoate--beta-alanine ligase; Region: panC; TIGR00018 698973006753 Pantoate-beta-alanine ligase; Region: PanC; cd00560 698973006754 active site 698973006755 ATP-binding site [chemical binding]; other site 698973006756 pantoate-binding site; other site 698973006757 HXXH motif; other site 698973006758 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 698973006759 oligomerization interface [polypeptide binding]; other site 698973006760 active site 698973006761 metal binding site [ion binding]; metal-binding site 698973006762 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698973006763 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698973006764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698973006765 catalytic residue [active] 698973006766 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 698973006767 substrate binding site [chemical binding]; other site 698973006768 active site 698973006769 catalytic residues [active] 698973006770 heterodimer interface [polypeptide binding]; other site 698973006771 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698973006772 iron-sulfur cluster [ion binding]; other site 698973006773 [2Fe-2S] cluster binding site [ion binding]; other site 698973006774 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 698973006775 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698973006776 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 698973006777 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 698973006778 hypothetical protein; Validated; Region: PRK00228 698973006779 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 698973006780 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 698973006781 active site 698973006782 NTP binding site [chemical binding]; other site 698973006783 metal binding triad [ion binding]; metal-binding site 698973006784 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 698973006785 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698973006786 Zn2+ binding site [ion binding]; other site 698973006787 Mg2+ binding site [ion binding]; other site 698973006788 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 698973006789 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698973006790 active site 698973006791 Ap6A binding site [chemical binding]; other site 698973006792 nudix motif; other site 698973006793 metal binding site [ion binding]; metal-binding site 698973006794 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 698973006795 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 698973006796 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 698973006797 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698973006798 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698973006799 DNA binding residues [nucleotide binding] 698973006800 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 698973006801 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698973006802 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698973006803 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698973006804 catalytic residues [active] 698973006805 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698973006806 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698973006807 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 698973006808 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 698973006809 active site 698973006810 metal binding site [ion binding]; metal-binding site 698973006811 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 698973006812 ParB-like nuclease domain; Region: ParBc; pfam02195 698973006813 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698973006814 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698973006815 P-loop; other site 698973006816 Magnesium ion binding site [ion binding]; other site 698973006817 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698973006818 Magnesium ion binding site [ion binding]; other site 698973006819 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 698973006820 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 698973006821 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 698973006822 ribonuclease P; Reviewed; Region: rnpA; PRK03459 698973006823 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399