-- dump date 20140619_050808 -- class Genbank::misc_feature -- table misc_feature_note -- id note 698963000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698963000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 698963000003 Walker A motif; other site 698963000004 ATP binding site [chemical binding]; other site 698963000005 Walker B motif; other site 698963000006 arginine finger; other site 698963000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 698963000008 DnaA box-binding interface [nucleotide binding]; other site 698963000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 698963000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 698963000011 putative DNA binding surface [nucleotide binding]; other site 698963000012 dimer interface [polypeptide binding]; other site 698963000013 beta-clamp/clamp loader binding surface; other site 698963000014 beta-clamp/translesion DNA polymerase binding surface; other site 698963000015 recombination protein F; Reviewed; Region: recF; PRK00064 698963000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 698963000017 Walker A/P-loop; other site 698963000018 ATP binding site [chemical binding]; other site 698963000019 Q-loop/lid; other site 698963000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963000021 ABC transporter signature motif; other site 698963000022 Walker B; other site 698963000023 D-loop; other site 698963000024 H-loop/switch region; other site 698963000025 hypothetical protein; Provisional; Region: PRK00111 698963000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 698963000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698963000028 ATP binding site [chemical binding]; other site 698963000029 Mg2+ binding site [ion binding]; other site 698963000030 G-X-G motif; other site 698963000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698963000032 anchoring element; other site 698963000033 dimer interface [polypeptide binding]; other site 698963000034 ATP binding site [chemical binding]; other site 698963000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 698963000036 active site 698963000037 putative metal-binding site [ion binding]; other site 698963000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698963000039 DNA gyrase subunit A; Validated; Region: PRK05560 698963000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 698963000041 CAP-like domain; other site 698963000042 active site 698963000043 primary dimer interface [polypeptide binding]; other site 698963000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698963000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698963000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698963000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698963000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698963000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698963000050 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 698963000051 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698963000052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698963000053 DNA-binding site [nucleotide binding]; DNA binding site 698963000054 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698963000055 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698963000056 L-lactate permease; Region: Lactate_perm; cl00701 698963000057 Cadherin repeat-like domain; Region: CA_like; cl15786 698963000058 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698963000059 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698963000060 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 698963000061 Walker A/P-loop; other site 698963000062 ATP binding site [chemical binding]; other site 698963000063 Q-loop/lid; other site 698963000064 ABC transporter signature motif; other site 698963000065 Walker B; other site 698963000066 D-loop; other site 698963000067 H-loop/switch region; other site 698963000068 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698963000069 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698963000070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963000071 Walker A/P-loop; other site 698963000072 ATP binding site [chemical binding]; other site 698963000073 Q-loop/lid; other site 698963000074 ABC transporter signature motif; other site 698963000075 Walker B; other site 698963000076 D-loop; other site 698963000077 H-loop/switch region; other site 698963000078 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698963000079 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 698963000080 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698963000081 putative ligand binding site [chemical binding]; other site 698963000082 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698963000083 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698963000084 TM-ABC transporter signature motif; other site 698963000085 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698963000086 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698963000087 Walker A/P-loop; other site 698963000088 ATP binding site [chemical binding]; other site 698963000089 Q-loop/lid; other site 698963000090 ABC transporter signature motif; other site 698963000091 Walker B; other site 698963000092 D-loop; other site 698963000093 H-loop/switch region; other site 698963000094 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698963000095 active site 698963000096 Integrase core domain; Region: rve_2; pfam13333 698963000097 Rhomboid family; Region: Rhomboid; pfam01694 698963000098 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 698963000099 ThiC-associated domain; Region: ThiC-associated; pfam13667 698963000100 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 698963000101 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698963000102 thiamine phosphate binding site [chemical binding]; other site 698963000103 active site 698963000104 pyrophosphate binding site [ion binding]; other site 698963000105 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698963000106 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 698963000107 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 698963000108 thiS-thiF/thiG interaction site; other site 698963000109 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 698963000110 ThiS interaction site; other site 698963000111 putative active site [active] 698963000112 tetramer interface [polypeptide binding]; other site 698963000113 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 698963000114 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698963000115 ATP binding site [chemical binding]; other site 698963000116 substrate interface [chemical binding]; other site 698963000117 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698963000118 active site residue [active] 698963000119 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 698963000120 dimer interface [polypeptide binding]; other site 698963000121 substrate binding site [chemical binding]; other site 698963000122 ATP binding site [chemical binding]; other site 698963000123 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 698963000124 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 698963000125 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 698963000126 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 698963000127 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 698963000128 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 698963000129 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698963000130 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698963000131 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698963000132 MULE transposase domain; Region: MULE; pfam10551 698963000133 putative septation inhibitor protein; Reviewed; Region: PRK00159 698963000134 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698963000135 Protein kinase domain; Region: Pkinase; pfam00069 698963000136 active site 698963000137 ATP binding site [chemical binding]; other site 698963000138 substrate binding site [chemical binding]; other site 698963000139 activation loop (A-loop); other site 698963000140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698963000141 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698963000142 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698963000143 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698963000144 PASTA domain; Region: PASTA; pfam03793 698963000145 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698963000146 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698963000147 active site 698963000148 ATP binding site [chemical binding]; other site 698963000149 substrate binding site [chemical binding]; other site 698963000150 activation loop (A-loop); other site 698963000151 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698963000152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698963000153 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 698963000154 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 698963000155 Protein phosphatase 2C; Region: PP2C; pfam00481 698963000156 active site 698963000157 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698963000158 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698963000159 phosphopeptide binding site; other site 698963000160 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 698963000161 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698963000162 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698963000163 phosphopeptide binding site; other site 698963000164 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698963000165 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698963000166 non-specific DNA binding site [nucleotide binding]; other site 698963000167 salt bridge; other site 698963000168 sequence-specific DNA binding site [nucleotide binding]; other site 698963000169 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 698963000170 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 698963000171 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 698963000172 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698963000173 Walker A/P-loop; other site 698963000174 ATP binding site [chemical binding]; other site 698963000175 Q-loop/lid; other site 698963000176 ABC transporter signature motif; other site 698963000177 Walker B; other site 698963000178 D-loop; other site 698963000179 H-loop/switch region; other site 698963000180 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698963000181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698963000182 active site 698963000183 phosphorylation site [posttranslational modification] 698963000184 intermolecular recognition site; other site 698963000185 dimerization interface [polypeptide binding]; other site 698963000186 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698963000187 DNA binding residues [nucleotide binding] 698963000188 dimerization interface [polypeptide binding]; other site 698963000189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698963000190 Histidine kinase; Region: HisKA_3; pfam07730 698963000191 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698963000192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698963000193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698963000194 dimer interface [polypeptide binding]; other site 698963000195 conserved gate region; other site 698963000196 putative PBP binding loops; other site 698963000197 ABC-ATPase subunit interface; other site 698963000198 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 698963000199 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 698963000200 Walker A/P-loop; other site 698963000201 ATP binding site [chemical binding]; other site 698963000202 Q-loop/lid; other site 698963000203 ABC transporter signature motif; other site 698963000204 Walker B; other site 698963000205 D-loop; other site 698963000206 H-loop/switch region; other site 698963000207 Anti-sigma-K factor rskA; Region: RskA; pfam10099 698963000208 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 698963000209 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698963000210 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698963000211 DNA binding residues [nucleotide binding] 698963000212 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698963000213 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698963000214 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 698963000215 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698963000216 catalytic residues [active] 698963000217 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 698963000218 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698963000219 DNA binding residues [nucleotide binding] 698963000220 dimer interface [polypeptide binding]; other site 698963000221 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 698963000222 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 698963000223 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 698963000224 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 698963000225 putative metal binding site [ion binding]; other site 698963000226 biotin synthase; Validated; Region: PRK06256 698963000227 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698963000228 FeS/SAM binding site; other site 698963000229 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698963000230 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 698963000231 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 698963000232 putative ligand binding residues [chemical binding]; other site 698963000233 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698963000234 ABC-ATPase subunit interface; other site 698963000235 dimer interface [polypeptide binding]; other site 698963000236 putative PBP binding regions; other site 698963000237 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698963000238 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698963000239 Walker A/P-loop; other site 698963000240 ATP binding site [chemical binding]; other site 698963000241 Q-loop/lid; other site 698963000242 ABC transporter signature motif; other site 698963000243 Walker B; other site 698963000244 D-loop; other site 698963000245 H-loop/switch region; other site 698963000246 Uncharacterized conserved protein [Function unknown]; Region: COG5646 698963000247 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 698963000248 DNA photolyase; Region: DNA_photolyase; pfam00875 698963000249 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 698963000250 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 698963000251 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 698963000252 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 698963000253 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 698963000254 Lipase (class 2); Region: Lipase_2; pfam01674 698963000255 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 698963000256 dimer interface [polypeptide binding]; other site 698963000257 FMN binding site [chemical binding]; other site 698963000258 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698963000259 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 698963000260 putative DNA binding site [nucleotide binding]; other site 698963000261 putative Zn2+ binding site [ion binding]; other site 698963000262 Divergent AAA domain; Region: AAA_4; pfam04326 698963000263 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 698963000264 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 698963000265 trimer interface [polypeptide binding]; other site 698963000266 putative metal binding site [ion binding]; other site 698963000267 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698963000268 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 698963000269 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 698963000270 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 698963000271 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698963000272 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698963000273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 698963000274 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698963000275 MarR family; Region: MarR; pfam01047 698963000276 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 698963000277 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698963000278 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698963000279 hypothetical protein; Provisional; Region: PRK10621 698963000280 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698963000281 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 698963000282 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698963000283 ATP binding site [chemical binding]; other site 698963000284 putative Mg++ binding site [ion binding]; other site 698963000285 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698963000286 nucleotide binding region [chemical binding]; other site 698963000287 Helicase associated domain (HA2); Region: HA2; pfam04408 698963000288 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 698963000289 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698963000290 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698963000291 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 698963000292 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698963000293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698963000294 NAD(P) binding site [chemical binding]; other site 698963000295 active site 698963000296 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698963000297 potential frameshift: common BLAST hit: gi|336325819|ref|YP_004605785.1| transposase for insertion sequence element 698963000298 Helix-turn-helix domain; Region: HTH_38; pfam13936 698963000299 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698963000300 Integrase core domain; Region: rve; pfam00665 698963000301 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 698963000302 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 698963000303 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698963000304 RNA binding surface [nucleotide binding]; other site 698963000305 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698963000306 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698963000307 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698963000308 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 698963000309 active site 698963000310 DNA binding site [nucleotide binding] 698963000311 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 698963000312 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 698963000313 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 698963000314 active site 698963000315 Zn binding site [ion binding]; other site 698963000316 Protease prsW family; Region: PrsW-protease; pfam13367 698963000317 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698963000318 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 698963000319 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 698963000320 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 698963000321 short chain dehydrogenase; Provisional; Region: PRK07904 698963000322 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698963000323 NAD(P) binding site [chemical binding]; other site 698963000324 active site 698963000325 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698963000326 FAD binding domain; Region: FAD_binding_4; pfam01565 698963000327 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 698963000328 Predicted membrane protein [Function unknown]; Region: COG2246 698963000329 GtrA-like protein; Region: GtrA; pfam04138 698963000330 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698963000331 putative active site [active] 698963000332 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698963000333 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698963000334 active site 698963000335 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698963000336 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698963000337 intersubunit interface [polypeptide binding]; other site 698963000338 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698963000339 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698963000340 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698963000341 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698963000342 ABC-ATPase subunit interface; other site 698963000343 dimer interface [polypeptide binding]; other site 698963000344 putative PBP binding regions; other site 698963000345 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698963000346 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698963000347 ABC-ATPase subunit interface; other site 698963000348 dimer interface [polypeptide binding]; other site 698963000349 putative PBP binding regions; other site 698963000350 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698963000351 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698963000352 intersubunit interface [polypeptide binding]; other site 698963000353 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 698963000354 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 698963000355 Walker A/P-loop; other site 698963000356 ATP binding site [chemical binding]; other site 698963000357 Q-loop/lid; other site 698963000358 ABC transporter signature motif; other site 698963000359 Walker B; other site 698963000360 D-loop; other site 698963000361 H-loop/switch region; other site 698963000362 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 698963000363 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698963000364 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698963000365 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698963000366 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698963000367 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 698963000368 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 698963000369 NAD(P) binding site [chemical binding]; other site 698963000370 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 698963000371 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698963000372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698963000373 homodimer interface [polypeptide binding]; other site 698963000374 catalytic residue [active] 698963000375 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 698963000376 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 698963000377 transmembrane helices; other site 698963000378 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 698963000379 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 698963000380 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698963000381 active site 698963000382 catalytic residues [active] 698963000383 DNA binding site [nucleotide binding] 698963000384 Int/Topo IB signature motif; other site 698963000385 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698963000386 sequence-specific DNA binding site [nucleotide binding]; other site 698963000387 salt bridge; other site 698963000388 Domain of unknown function (DUF955); Region: DUF955; cl01076 698963000389 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698963000390 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698963000391 non-specific DNA binding site [nucleotide binding]; other site 698963000392 salt bridge; other site 698963000393 sequence-specific DNA binding site [nucleotide binding]; other site 698963000394 Prophage antirepressor [Transcription]; Region: COG3617 698963000395 BRO family, N-terminal domain; Region: Bro-N; smart01040 698963000396 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 698963000397 Helix-turn-helix domain; Region: HTH_17; pfam12728 698963000398 Phage Terminase; Region: Terminase_1; pfam03354 698963000399 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698963000400 Phage-related protein [Function unknown]; Region: COG4695; cl01923 698963000401 Phage portal protein; Region: Phage_portal; pfam04860 698963000402 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 698963000403 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 698963000404 Phage capsid family; Region: Phage_capsid; pfam05065 698963000405 Phage-related minor tail protein [Function unknown]; Region: COG5280 698963000406 MAEBL; Provisional; Region: PTZ00121 698963000407 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698963000408 amidase catalytic site [active] 698963000409 Zn binding residues [ion binding]; other site 698963000410 substrate binding site [chemical binding]; other site 698963000411 ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; Region: ADP_ribosyl; cd01341 698963000412 nad+ binding pocket [chemical binding]; other site 698963000413 Diphtheria toxin, T domain; Region: Diphtheria_T; pfam02764 698963000414 Diphtheria toxin, R domain; Region: Diphtheria_R; pfam01324 698963000415 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698963000416 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 698963000417 NodB motif; other site 698963000418 active site 698963000419 catalytic site [active] 698963000420 metal binding site [ion binding]; metal-binding site 698963000421 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698963000422 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698963000423 DNA-binding site [nucleotide binding]; DNA binding site 698963000424 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698963000425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698963000426 homodimer interface [polypeptide binding]; other site 698963000427 catalytic residue [active] 698963000428 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 698963000429 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 698963000430 active site 698963000431 multimer interface [polypeptide binding]; other site 698963000432 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 698963000433 predicted active site [active] 698963000434 catalytic triad [active] 698963000435 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 698963000436 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698963000437 active site 698963000438 catalytic site [active] 698963000439 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698963000440 active site 698963000441 catalytic site [active] 698963000442 Domain of unknown function DUF11; Region: DUF11; cl17728 698963000443 Transposase; Region: HTH_Tnp_1; cl17663 698963000444 Ribosome inactivating protein; Region: RIP; pfam00161 698963000445 prephenate dehydrogenase; Validated; Region: PRK06545 698963000446 prephenate dehydrogenase; Validated; Region: PRK08507 698963000447 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 698963000448 nucleoside/Zn binding site; other site 698963000449 dimer interface [polypeptide binding]; other site 698963000450 catalytic motif [active] 698963000451 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 698963000452 DNA binding residues [nucleotide binding] 698963000453 PIN domain; Region: PIN_3; pfam13470 698963000454 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 698963000455 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 698963000456 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 698963000457 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 698963000458 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 698963000459 active site 698963000460 HIGH motif; other site 698963000461 nucleotide binding site [chemical binding]; other site 698963000462 active site 698963000463 KMSKS motif; other site 698963000464 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 698963000465 fructuronate transporter; Provisional; Region: PRK10034; cl15264 698963000466 Shikimate kinase; Region: SKI; pfam01202 698963000467 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 698963000468 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 698963000469 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 698963000470 putative NAD(P) binding site [chemical binding]; other site 698963000471 catalytic Zn binding site [ion binding]; other site 698963000472 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 698963000473 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 698963000474 NADP binding site [chemical binding]; other site 698963000475 homodimer interface [polypeptide binding]; other site 698963000476 active site 698963000477 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 698963000478 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698963000479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698963000480 homodimer interface [polypeptide binding]; other site 698963000481 catalytic residue [active] 698963000482 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 698963000483 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 698963000484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698963000485 Walker A motif; other site 698963000486 ATP binding site [chemical binding]; other site 698963000487 Walker B motif; other site 698963000488 arginine finger; other site 698963000489 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 698963000490 hypothetical protein; Validated; Region: PRK00153 698963000491 recombination protein RecR; Reviewed; Region: recR; PRK00076 698963000492 RecR protein; Region: RecR; pfam02132 698963000493 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 698963000494 putative active site [active] 698963000495 putative metal-binding site [ion binding]; other site 698963000496 tetramer interface [polypeptide binding]; other site 698963000497 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698963000498 catalytic triad [active] 698963000499 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 698963000500 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698963000501 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 698963000502 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 698963000503 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698963000504 active site 698963000505 catalytic site [active] 698963000506 substrate binding site [chemical binding]; other site 698963000507 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 698963000508 dimer interface [polypeptide binding]; other site 698963000509 FMN binding site [chemical binding]; other site 698963000510 NADPH bind site [chemical binding]; other site 698963000511 2-isopropylmalate synthase; Validated; Region: PRK03739 698963000512 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 698963000513 active site 698963000514 catalytic residues [active] 698963000515 metal binding site [ion binding]; metal-binding site 698963000516 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 698963000517 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698963000518 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698963000519 DNA binding residues [nucleotide binding] 698963000520 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698963000521 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698963000522 active site 698963000523 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 698963000524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698963000525 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698963000526 putative substrate translocation pore; other site 698963000527 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 698963000528 intersubunit interface [polypeptide binding]; other site 698963000529 active site 698963000530 catalytic residue [active] 698963000531 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 698963000532 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 698963000533 active site 698963000534 substrate binding site [chemical binding]; other site 698963000535 metal binding site [ion binding]; metal-binding site 698963000536 aspartate kinase; Reviewed; Region: PRK06635 698963000537 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 698963000538 putative nucleotide binding site [chemical binding]; other site 698963000539 putative catalytic residues [active] 698963000540 putative Mg ion binding site [ion binding]; other site 698963000541 putative aspartate binding site [chemical binding]; other site 698963000542 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 698963000543 putative allosteric regulatory site; other site 698963000544 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 698963000545 putative allosteric regulatory residue; other site 698963000546 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 698963000547 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698963000548 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698963000549 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698963000550 active site 698963000551 catalytic site [active] 698963000552 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698963000553 active site 698963000554 catalytic site [active] 698963000555 RNA polymerase sigma factor; Provisional; Region: PRK12535 698963000556 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698963000557 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698963000558 DNA binding residues [nucleotide binding] 698963000559 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 698963000560 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 698963000561 heme binding pocket [chemical binding]; other site 698963000562 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698963000563 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 698963000564 Walker A/P-loop; other site 698963000565 ATP binding site [chemical binding]; other site 698963000566 Q-loop/lid; other site 698963000567 ABC transporter signature motif; other site 698963000568 Walker B; other site 698963000569 D-loop; other site 698963000570 H-loop/switch region; other site 698963000571 TOBE domain; Region: TOBE_2; pfam08402 698963000572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698963000573 dimer interface [polypeptide binding]; other site 698963000574 conserved gate region; other site 698963000575 ABC-ATPase subunit interface; other site 698963000576 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698963000577 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 698963000578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698963000579 putative substrate translocation pore; other site 698963000580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698963000581 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698963000582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698963000583 active site 698963000584 phosphorylation site [posttranslational modification] 698963000585 intermolecular recognition site; other site 698963000586 dimerization interface [polypeptide binding]; other site 698963000587 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698963000588 DNA binding site [nucleotide binding] 698963000589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698963000590 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698963000591 dimer interface [polypeptide binding]; other site 698963000592 phosphorylation site [posttranslational modification] 698963000593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698963000594 ATP binding site [chemical binding]; other site 698963000595 Mg2+ binding site [ion binding]; other site 698963000596 G-X-G motif; other site 698963000597 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 698963000598 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 698963000599 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 698963000600 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 698963000601 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698963000602 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 698963000603 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 698963000604 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698963000605 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 698963000606 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698963000607 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698963000608 Predicted membrane protein [Function unknown]; Region: COG1511 698963000609 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698963000610 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698963000611 putative active site [active] 698963000612 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 698963000613 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698963000614 putative active site [active] 698963000615 putative metal binding site [ion binding]; other site 698963000616 Yqey-like protein; Region: YqeY; pfam09424 698963000617 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698963000618 Transglycosylase; Region: Transgly; pfam00912 698963000619 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698963000620 PASTA domain; Region: PASTA; pfam03793 698963000621 Transcription factor WhiB; Region: Whib; pfam02467 698963000622 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 698963000623 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 698963000624 homotrimer interaction site [polypeptide binding]; other site 698963000625 putative active site [active] 698963000626 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698963000627 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698963000628 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698963000629 ligand binding site [chemical binding]; other site 698963000630 flexible hinge region; other site 698963000631 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698963000632 putative switch regulator; other site 698963000633 non-specific DNA interactions [nucleotide binding]; other site 698963000634 DNA binding site [nucleotide binding] 698963000635 sequence specific DNA binding site [nucleotide binding]; other site 698963000636 putative cAMP binding site [chemical binding]; other site 698963000637 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 698963000638 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698963000639 minor groove reading motif; other site 698963000640 helix-hairpin-helix signature motif; other site 698963000641 substrate binding pocket [chemical binding]; other site 698963000642 active site 698963000643 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 698963000644 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698963000645 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698963000646 catalytic residues [active] 698963000647 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 698963000648 putative active site [active] 698963000649 putative CoA binding site [chemical binding]; other site 698963000650 nudix motif; other site 698963000651 metal binding site [ion binding]; metal-binding site 698963000652 Colicin V production protein; Region: Colicin_V; pfam02674 698963000653 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 698963000654 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698963000655 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698963000656 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698963000657 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 698963000658 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698963000659 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698963000660 motif II; other site 698963000661 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 698963000662 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 698963000663 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 698963000664 ATP binding site [chemical binding]; other site 698963000665 Walker A motif; other site 698963000666 hexamer interface [polypeptide binding]; other site 698963000667 Walker B motif; other site 698963000668 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 698963000669 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 698963000670 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 698963000671 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698963000672 ATP binding site [chemical binding]; other site 698963000673 putative Mg++ binding site [ion binding]; other site 698963000674 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698963000675 nucleotide binding region [chemical binding]; other site 698963000676 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 698963000677 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698963000678 DNA-binding site [nucleotide binding]; DNA binding site 698963000679 RNA-binding motif; other site 698963000680 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698963000681 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698963000682 Walker A/P-loop; other site 698963000683 ATP binding site [chemical binding]; other site 698963000684 Q-loop/lid; other site 698963000685 ABC transporter signature motif; other site 698963000686 Walker B; other site 698963000687 D-loop; other site 698963000688 H-loop/switch region; other site 698963000689 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698963000690 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698963000691 Walker A/P-loop; other site 698963000692 ATP binding site [chemical binding]; other site 698963000693 Q-loop/lid; other site 698963000694 ABC transporter signature motif; other site 698963000695 Walker B; other site 698963000696 D-loop; other site 698963000697 H-loop/switch region; other site 698963000698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698963000699 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698963000700 putative substrate translocation pore; other site 698963000701 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698963000702 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 698963000703 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698963000704 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 698963000705 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698963000706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698963000707 dimer interface [polypeptide binding]; other site 698963000708 conserved gate region; other site 698963000709 putative PBP binding loops; other site 698963000710 ABC-ATPase subunit interface; other site 698963000711 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698963000712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698963000713 NAD(P) binding site [chemical binding]; other site 698963000714 active site 698963000715 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 698963000716 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 698963000717 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 698963000718 active site 698963000719 interdomain interaction site; other site 698963000720 putative metal-binding site [ion binding]; other site 698963000721 nucleotide binding site [chemical binding]; other site 698963000722 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 698963000723 domain I; other site 698963000724 DNA binding groove [nucleotide binding] 698963000725 phosphate binding site [ion binding]; other site 698963000726 domain II; other site 698963000727 domain III; other site 698963000728 nucleotide binding site [chemical binding]; other site 698963000729 catalytic site [active] 698963000730 domain IV; other site 698963000731 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 698963000732 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698963000733 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698963000734 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698963000735 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698963000736 active site 698963000737 Predicted membrane protein [Function unknown]; Region: COG1297 698963000738 putative oligopeptide transporter, OPT family; Region: TIGR00733 698963000739 Laminin G domain; Region: Laminin_G_2; pfam02210 698963000740 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698963000741 catalytic site [active] 698963000742 Asp-box motif; other site 698963000743 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698963000744 dimerization interface [polypeptide binding]; other site 698963000745 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698963000746 cyclase homology domain; Region: CHD; cd07302 698963000747 nucleotidyl binding site; other site 698963000748 metal binding site [ion binding]; metal-binding site 698963000749 dimer interface [polypeptide binding]; other site 698963000750 DNA polymerase III subunit delta'; Validated; Region: PRK07940 698963000751 DNA polymerase III subunit delta'; Validated; Region: PRK08485 698963000752 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 698963000753 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698963000754 active site 698963000755 catalytic residues [active] 698963000756 DNA binding site [nucleotide binding] 698963000757 Int/Topo IB signature motif; other site 698963000758 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 698963000759 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698963000760 Helix-turn-helix domain; Region: HTH_38; pfam13936 698963000761 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698963000762 Integrase core domain; Region: rve; pfam00665 698963000763 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698963000764 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698963000765 Fic family protein [Function unknown]; Region: COG3177 698963000766 Fic/DOC family; Region: Fic; pfam02661 698963000767 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698963000768 Trypsin; Region: Trypsin; pfam00089 698963000769 active site 698963000770 Integrase core domain; Region: rve_3; cl15866 698963000771 Integrase core domain; Region: rve; pfam00665 698963000772 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698963000773 Integrase core domain; Region: rve; pfam00665 698963000774 HTH-like domain; Region: HTH_21; pfam13276 698963000775 acyl-CoA synthetase; Validated; Region: PRK07788 698963000776 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698963000777 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698963000778 acyl-activating enzyme (AAE) consensus motif; other site 698963000779 acyl-activating enzyme (AAE) consensus motif; other site 698963000780 AMP binding site [chemical binding]; other site 698963000781 active site 698963000782 CoA binding site [chemical binding]; other site 698963000783 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 698963000784 active site 698963000785 catalytic triad [active] 698963000786 oxyanion hole [active] 698963000787 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 698963000788 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 698963000789 substrate binding site; other site 698963000790 tetramer interface; other site 698963000791 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 698963000792 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 698963000793 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 698963000794 NADP binding site [chemical binding]; other site 698963000795 active site 698963000796 putative substrate binding site [chemical binding]; other site 698963000797 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 698963000798 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 698963000799 NAD binding site [chemical binding]; other site 698963000800 substrate binding site [chemical binding]; other site 698963000801 homodimer interface [polypeptide binding]; other site 698963000802 active site 698963000803 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 698963000804 Zn binding site [ion binding]; other site 698963000805 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 698963000806 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698963000807 Putative esterase; Region: Esterase; pfam00756 698963000808 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 698963000809 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 698963000810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698963000811 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698963000812 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698963000813 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698963000814 non-specific DNA binding site [nucleotide binding]; other site 698963000815 salt bridge; other site 698963000816 sequence-specific DNA binding site [nucleotide binding]; other site 698963000817 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 698963000818 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698963000819 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 698963000820 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 698963000821 putative Iron-sulfur protein interface [polypeptide binding]; other site 698963000822 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 698963000823 proximal heme binding site [chemical binding]; other site 698963000824 distal heme binding site [chemical binding]; other site 698963000825 putative dimer interface [polypeptide binding]; other site 698963000826 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 698963000827 L-aspartate oxidase; Provisional; Region: PRK06175 698963000828 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 698963000829 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 698963000830 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 698963000831 Predicted membrane protein [Function unknown]; Region: COG2733 698963000832 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 698963000833 Class I aldolases; Region: Aldolase_Class_I; cd00945 698963000834 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698963000835 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 698963000836 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698963000837 FeS/SAM binding site; other site 698963000838 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 698963000839 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698963000840 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 698963000841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698963000842 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 698963000843 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 698963000844 FAD binding domain; Region: FAD_binding_4; pfam01565 698963000845 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 698963000846 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698963000847 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698963000848 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698963000849 acyl-activating enzyme (AAE) consensus motif; other site 698963000850 AMP binding site [chemical binding]; other site 698963000851 active site 698963000852 CoA binding site [chemical binding]; other site 698963000853 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698963000854 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698963000855 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698963000856 acyl-activating enzyme (AAE) consensus motif; other site 698963000857 AMP binding site [chemical binding]; other site 698963000858 active site 698963000859 CoA binding site [chemical binding]; other site 698963000860 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 698963000861 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 698963000862 putative ADP-binding pocket [chemical binding]; other site 698963000863 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698963000864 catalytic core [active] 698963000865 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698963000866 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698963000867 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698963000868 dimer interface [polypeptide binding]; other site 698963000869 phosphorylation site [posttranslational modification] 698963000870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698963000871 ATP binding site [chemical binding]; other site 698963000872 Mg2+ binding site [ion binding]; other site 698963000873 G-X-G motif; other site 698963000874 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698963000875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698963000876 active site 698963000877 phosphorylation site [posttranslational modification] 698963000878 intermolecular recognition site; other site 698963000879 dimerization interface [polypeptide binding]; other site 698963000880 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698963000881 DNA binding site [nucleotide binding] 698963000882 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698963000883 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 698963000884 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 698963000885 DNA binding domain, excisionase family; Region: excise; TIGR01764 698963000886 Thioredoxin; Region: Thioredoxin_4; cl17273 698963000887 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698963000888 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698963000889 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 698963000890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698963000891 motif II; other site 698963000892 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 698963000893 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 698963000894 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 698963000895 tRNA; other site 698963000896 putative tRNA binding site [nucleotide binding]; other site 698963000897 putative NADP binding site [chemical binding]; other site 698963000898 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 698963000899 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 698963000900 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 698963000901 domain interfaces; other site 698963000902 active site 698963000903 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 698963000904 active site 698963000905 homodimer interface [polypeptide binding]; other site 698963000906 SAM binding site [chemical binding]; other site 698963000907 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 698963000908 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 698963000909 active site 698963000910 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 698963000911 dimer interface [polypeptide binding]; other site 698963000912 active site 698963000913 Schiff base residues; other site 698963000914 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 698963000915 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698963000916 Predicted membrane protein [Function unknown]; Region: COG2311 698963000917 Protein of unknown function (DUF418); Region: DUF418; pfam04235 698963000918 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 698963000919 substrate binding site [chemical binding]; other site 698963000920 active site 698963000921 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698963000922 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 698963000923 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 698963000924 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698963000925 inhibitor-cofactor binding pocket; inhibition site 698963000926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698963000927 catalytic residue [active] 698963000928 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698963000929 catalytic core [active] 698963000930 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698963000931 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698963000932 catalytic residues [active] 698963000933 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698963000934 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698963000935 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 698963000936 ResB-like family; Region: ResB; pfam05140 698963000937 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 698963000938 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698963000939 dimerization interface [polypeptide binding]; other site 698963000940 putative DNA binding site [nucleotide binding]; other site 698963000941 putative Zn2+ binding site [ion binding]; other site 698963000942 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 698963000943 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 698963000944 UbiA prenyltransferase family; Region: UbiA; pfam01040 698963000945 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698963000946 active site 698963000947 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698963000948 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 698963000949 acyl-activating enzyme (AAE) consensus motif; other site 698963000950 AMP binding site [chemical binding]; other site 698963000951 active site 698963000952 CoA binding site [chemical binding]; other site 698963000953 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698963000954 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 698963000955 substrate binding site [chemical binding]; other site 698963000956 oxyanion hole (OAH) forming residues; other site 698963000957 trimer interface [polypeptide binding]; other site 698963000958 O-succinylbenzoate synthase; Provisional; Region: PRK02901 698963000959 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 698963000960 active site 698963000961 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 698963000962 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 698963000963 dimer interface [polypeptide binding]; other site 698963000964 tetramer interface [polypeptide binding]; other site 698963000965 PYR/PP interface [polypeptide binding]; other site 698963000966 TPP binding site [chemical binding]; other site 698963000967 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 698963000968 TPP-binding site; other site 698963000969 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698963000970 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 698963000971 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 698963000972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698963000973 S-adenosylmethionine binding site [chemical binding]; other site 698963000974 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 698963000975 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 698963000976 NAD binding site [chemical binding]; other site 698963000977 dimer interface [polypeptide binding]; other site 698963000978 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698963000979 substrate binding site [chemical binding]; other site 698963000980 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 698963000981 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698963000982 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698963000983 substrate binding pocket [chemical binding]; other site 698963000984 chain length determination region; other site 698963000985 substrate-Mg2+ binding site; other site 698963000986 catalytic residues [active] 698963000987 aspartate-rich region 1; other site 698963000988 active site lid residues [active] 698963000989 aspartate-rich region 2; other site 698963000990 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 698963000991 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 698963000992 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 698963000993 putative homodimer interface [polypeptide binding]; other site 698963000994 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 698963000995 heterodimer interface [polypeptide binding]; other site 698963000996 homodimer interface [polypeptide binding]; other site 698963000997 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 698963000998 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 698963000999 23S rRNA interface [nucleotide binding]; other site 698963001000 L7/L12 interface [polypeptide binding]; other site 698963001001 putative thiostrepton binding site; other site 698963001002 L25 interface [polypeptide binding]; other site 698963001003 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 698963001004 mRNA/rRNA interface [nucleotide binding]; other site 698963001005 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 698963001006 23S rRNA interface [nucleotide binding]; other site 698963001007 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 698963001008 50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157 698963001009 L11 interface [polypeptide binding]; other site 698963001010 putative EF-Tu interaction site [polypeptide binding]; other site 698963001011 putative EF-G interaction site [polypeptide binding]; other site 698963001012 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 698963001013 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698963001014 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698963001015 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698963001016 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698963001017 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698963001018 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 698963001019 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698963001020 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698963001021 ABC-ATPase subunit interface; other site 698963001022 dimer interface [polypeptide binding]; other site 698963001023 putative PBP binding regions; other site 698963001024 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698963001025 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698963001026 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698963001027 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698963001028 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 698963001029 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 698963001030 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 698963001031 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 698963001032 RPB1 interaction site [polypeptide binding]; other site 698963001033 RPB10 interaction site [polypeptide binding]; other site 698963001034 RPB11 interaction site [polypeptide binding]; other site 698963001035 RPB3 interaction site [polypeptide binding]; other site 698963001036 RPB12 interaction site [polypeptide binding]; other site 698963001037 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 698963001038 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 698963001039 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 698963001040 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 698963001041 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 698963001042 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698963001043 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 698963001044 G-loop; other site 698963001045 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698963001046 DNA binding site [nucleotide binding] 698963001047 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 698963001048 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698963001049 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698963001050 Walker A/P-loop; other site 698963001051 ATP binding site [chemical binding]; other site 698963001052 Q-loop/lid; other site 698963001053 ABC transporter signature motif; other site 698963001054 Walker B; other site 698963001055 D-loop; other site 698963001056 H-loop/switch region; other site 698963001057 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 698963001058 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698963001059 FeS/SAM binding site; other site 698963001060 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 698963001061 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698963001062 Histidine kinase; Region: HisKA_3; pfam07730 698963001063 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698963001064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698963001065 active site 698963001066 phosphorylation site [posttranslational modification] 698963001067 intermolecular recognition site; other site 698963001068 dimerization interface [polypeptide binding]; other site 698963001069 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698963001070 DNA binding residues [nucleotide binding] 698963001071 dimerization interface [polypeptide binding]; other site 698963001072 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698963001073 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698963001074 Walker A/P-loop; other site 698963001075 ATP binding site [chemical binding]; other site 698963001076 Q-loop/lid; other site 698963001077 ABC transporter signature motif; other site 698963001078 Walker B; other site 698963001079 D-loop; other site 698963001080 H-loop/switch region; other site 698963001081 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 698963001082 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698963001083 TIGR03943 family protein; Region: TIGR03943 698963001084 Predicted permeases [General function prediction only]; Region: COG0701 698963001085 Radical SAM superfamily; Region: Radical_SAM; pfam04055 698963001086 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698963001087 FeS/SAM binding site; other site 698963001088 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 698963001089 Class III ribonucleotide reductase; Region: RNR_III; cd01675 698963001090 effector binding site; other site 698963001091 active site 698963001092 Zn binding site [ion binding]; other site 698963001093 glycine loop; other site 698963001094 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 698963001095 S17 interaction site [polypeptide binding]; other site 698963001096 S8 interaction site; other site 698963001097 16S rRNA interaction site [nucleotide binding]; other site 698963001098 streptomycin interaction site [chemical binding]; other site 698963001099 23S rRNA interaction site [nucleotide binding]; other site 698963001100 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 698963001101 30S ribosomal protein S7; Validated; Region: PRK05302 698963001102 elongation factor G; Reviewed; Region: PRK00007 698963001103 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 698963001104 G1 box; other site 698963001105 putative GEF interaction site [polypeptide binding]; other site 698963001106 GTP/Mg2+ binding site [chemical binding]; other site 698963001107 Switch I region; other site 698963001108 G2 box; other site 698963001109 G3 box; other site 698963001110 Switch II region; other site 698963001111 G4 box; other site 698963001112 G5 box; other site 698963001113 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 698963001114 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 698963001115 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 698963001116 elongation factor Tu; Reviewed; Region: PRK00049 698963001117 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 698963001118 G1 box; other site 698963001119 GEF interaction site [polypeptide binding]; other site 698963001120 GTP/Mg2+ binding site [chemical binding]; other site 698963001121 Switch I region; other site 698963001122 G2 box; other site 698963001123 G3 box; other site 698963001124 Switch II region; other site 698963001125 G4 box; other site 698963001126 G5 box; other site 698963001127 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 698963001128 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 698963001129 Antibiotic Binding Site [chemical binding]; other site 698963001130 Predicted membrane protein [Function unknown]; Region: COG2323 698963001131 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 698963001132 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 698963001133 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 698963001134 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 698963001135 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 698963001136 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 698963001137 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 698963001138 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 698963001139 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 698963001140 putative translocon binding site; other site 698963001141 protein-rRNA interface [nucleotide binding]; other site 698963001142 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 698963001143 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 698963001144 G-X-X-G motif; other site 698963001145 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 698963001146 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 698963001147 23S rRNA interface [nucleotide binding]; other site 698963001148 5S rRNA interface [nucleotide binding]; other site 698963001149 putative antibiotic binding site [chemical binding]; other site 698963001150 L25 interface [polypeptide binding]; other site 698963001151 L27 interface [polypeptide binding]; other site 698963001152 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 698963001153 putative translocon interaction site; other site 698963001154 23S rRNA interface [nucleotide binding]; other site 698963001155 signal recognition particle (SRP54) interaction site; other site 698963001156 L23 interface [polypeptide binding]; other site 698963001157 trigger factor interaction site; other site 698963001158 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 698963001159 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698963001160 HlyD family secretion protein; Region: HlyD_3; pfam13437 698963001161 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698963001162 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698963001163 Walker A/P-loop; other site 698963001164 ATP binding site [chemical binding]; other site 698963001165 Q-loop/lid; other site 698963001166 ABC transporter signature motif; other site 698963001167 Walker B; other site 698963001168 D-loop; other site 698963001169 H-loop/switch region; other site 698963001170 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698963001171 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698963001172 FtsX-like permease family; Region: FtsX; pfam02687 698963001173 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 698963001174 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 698963001175 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 698963001176 RNA binding site [nucleotide binding]; other site 698963001177 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 698963001178 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 698963001179 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 698963001180 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 698963001181 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 698963001182 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698963001183 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698963001184 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698963001185 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698963001186 active site 698963001187 homotetramer interface [polypeptide binding]; other site 698963001188 homodimer interface [polypeptide binding]; other site 698963001189 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 698963001190 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698963001191 ATP binding site [chemical binding]; other site 698963001192 substrate interface [chemical binding]; other site 698963001193 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698963001194 active site residue [active] 698963001195 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698963001196 MPT binding site; other site 698963001197 trimer interface [polypeptide binding]; other site 698963001198 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 698963001199 MoaE homodimer interface [polypeptide binding]; other site 698963001200 MoaD interaction [polypeptide binding]; other site 698963001201 active site residues [active] 698963001202 Ubiquitin-like proteins; Region: UBQ; cl00155 698963001203 charged pocket; other site 698963001204 hydrophobic patch; other site 698963001205 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698963001206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698963001207 putative PBP binding loops; other site 698963001208 ABC-ATPase subunit interface; other site 698963001209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963001210 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698963001211 Walker A/P-loop; other site 698963001212 ATP binding site [chemical binding]; other site 698963001213 Q-loop/lid; other site 698963001214 ABC transporter signature motif; other site 698963001215 Walker B; other site 698963001216 D-loop; other site 698963001217 H-loop/switch region; other site 698963001218 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 698963001219 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 698963001220 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 698963001221 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 698963001222 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 698963001223 [4Fe-4S] binding site [ion binding]; other site 698963001224 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698963001225 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698963001226 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698963001227 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 698963001228 molybdopterin cofactor binding site; other site 698963001229 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 698963001230 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 698963001231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698963001232 putative substrate translocation pore; other site 698963001233 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698963001234 MPT binding site; other site 698963001235 trimer interface [polypeptide binding]; other site 698963001236 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 698963001237 GTP binding site; other site 698963001238 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 698963001239 trimer interface [polypeptide binding]; other site 698963001240 dimer interface [polypeptide binding]; other site 698963001241 putative active site [active] 698963001242 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698963001243 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698963001244 dimer interface [polypeptide binding]; other site 698963001245 putative functional site; other site 698963001246 putative MPT binding site; other site 698963001247 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 698963001248 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698963001249 FeS/SAM binding site; other site 698963001250 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 698963001251 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 698963001252 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698963001253 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698963001254 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 698963001255 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 698963001256 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 698963001257 Integrase core domain; Region: rve_3; cl15866 698963001258 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 698963001259 hypothetical protein; Reviewed; Region: PRK09588 698963001260 Fic/DOC family; Region: Fic; pfam02661 698963001261 potential frameshift: common BLAST hit: gi|261416833|ref|YP_003250516.1| type II restriction enzyme (methylase subunit) 698963001262 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698963001263 potential frameshift: common BLAST hit: gi|224369162|ref|YP_002603326.1| putative type II restriction enzyme (methylase subunit) 698963001264 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698963001265 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698963001266 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698963001267 inhibitor site; inhibition site 698963001268 active site 698963001269 dimer interface [polypeptide binding]; other site 698963001270 catalytic residue [active] 698963001271 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698963001272 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698963001273 Walker A/P-loop; other site 698963001274 ATP binding site [chemical binding]; other site 698963001275 Q-loop/lid; other site 698963001276 ABC transporter signature motif; other site 698963001277 Walker B; other site 698963001278 D-loop; other site 698963001279 H-loop/switch region; other site 698963001280 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698963001281 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698963001282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698963001283 dimer interface [polypeptide binding]; other site 698963001284 conserved gate region; other site 698963001285 putative PBP binding loops; other site 698963001286 ABC-ATPase subunit interface; other site 698963001287 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698963001288 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698963001289 Walker A/P-loop; other site 698963001290 ATP binding site [chemical binding]; other site 698963001291 Q-loop/lid; other site 698963001292 ABC transporter signature motif; other site 698963001293 Walker B; other site 698963001294 D-loop; other site 698963001295 H-loop/switch region; other site 698963001296 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698963001297 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698963001298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698963001299 dimer interface [polypeptide binding]; other site 698963001300 conserved gate region; other site 698963001301 putative PBP binding loops; other site 698963001302 ABC-ATPase subunit interface; other site 698963001303 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 698963001304 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698963001305 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698963001306 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698963001307 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698963001308 DNA-binding site [nucleotide binding]; DNA binding site 698963001309 FCD domain; Region: FCD; pfam07729 698963001310 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698963001311 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698963001312 nucleotide binding site [chemical binding]; other site 698963001313 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 698963001314 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 698963001315 putative active site cavity [active] 698963001316 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 698963001317 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 698963001318 active site 698963001319 dimer interface [polypeptide binding]; other site 698963001320 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698963001321 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 698963001322 active site 698963001323 trimer interface [polypeptide binding]; other site 698963001324 allosteric site; other site 698963001325 active site lid [active] 698963001326 hexamer (dimer of trimers) interface [polypeptide binding]; other site 698963001327 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 698963001328 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 698963001329 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698963001330 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698963001331 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 698963001332 5S rRNA interface [nucleotide binding]; other site 698963001333 L27 interface [polypeptide binding]; other site 698963001334 23S rRNA interface [nucleotide binding]; other site 698963001335 L5 interface [polypeptide binding]; other site 698963001336 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 698963001337 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 698963001338 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 698963001339 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 698963001340 23S rRNA binding site [nucleotide binding]; other site 698963001341 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 698963001342 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 698963001343 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 698963001344 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 698963001345 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698963001346 active site 698963001347 catalytic site [active] 698963001348 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698963001349 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698963001350 active site 698963001351 catalytic site [active] 698963001352 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698963001353 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698963001354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698963001355 dimer interface [polypeptide binding]; other site 698963001356 conserved gate region; other site 698963001357 putative PBP binding loops; other site 698963001358 ABC-ATPase subunit interface; other site 698963001359 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698963001360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698963001361 dimer interface [polypeptide binding]; other site 698963001362 conserved gate region; other site 698963001363 putative PBP binding loops; other site 698963001364 ABC-ATPase subunit interface; other site 698963001365 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 698963001366 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698963001367 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698963001368 Walker A/P-loop; other site 698963001369 ATP binding site [chemical binding]; other site 698963001370 Q-loop/lid; other site 698963001371 ABC transporter signature motif; other site 698963001372 Walker B; other site 698963001373 D-loop; other site 698963001374 H-loop/switch region; other site 698963001375 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 698963001376 SecY translocase; Region: SecY; pfam00344 698963001377 adenylate kinase; Reviewed; Region: adk; PRK00279 698963001378 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 698963001379 AMP-binding site [chemical binding]; other site 698963001380 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 698963001381 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698963001382 active site 698963001383 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698963001384 catalytic site [active] 698963001385 BNR repeat-like domain; Region: BNR_2; pfam13088 698963001386 Asp-box motif; other site 698963001387 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698963001388 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 698963001389 rRNA binding site [nucleotide binding]; other site 698963001390 predicted 30S ribosome binding site; other site 698963001391 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 698963001392 30S ribosomal protein S13; Region: bact_S13; TIGR03631 698963001393 30S ribosomal protein S11; Validated; Region: PRK05309 698963001394 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 698963001395 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 698963001396 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698963001397 RNA binding surface [nucleotide binding]; other site 698963001398 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 698963001399 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 698963001400 alphaNTD - beta interaction site [polypeptide binding]; other site 698963001401 alphaNTD homodimer interface [polypeptide binding]; other site 698963001402 alphaNTD - beta' interaction site [polypeptide binding]; other site 698963001403 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 698963001404 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 698963001405 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 698963001406 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 698963001407 dimerization interface 3.5A [polypeptide binding]; other site 698963001408 active site 698963001409 Protein of unknown function (DUF690); Region: DUF690; cl04939 698963001410 TIGR02611 family protein; Region: TIGR02611 698963001411 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 698963001412 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 698963001413 active site 698963001414 catalytic residues [active] 698963001415 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 698963001416 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 698963001417 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698963001418 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 698963001419 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698963001420 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698963001421 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 698963001422 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 698963001423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 698963001424 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 698963001425 23S rRNA interface [nucleotide binding]; other site 698963001426 L3 interface [polypeptide binding]; other site 698963001427 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 698963001428 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 698963001429 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 698963001430 active site 698963001431 substrate binding site [chemical binding]; other site 698963001432 metal binding site [ion binding]; metal-binding site 698963001433 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 698963001434 alanine racemase; Reviewed; Region: alr; PRK00053 698963001435 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 698963001436 active site 698963001437 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698963001438 dimer interface [polypeptide binding]; other site 698963001439 substrate binding site [chemical binding]; other site 698963001440 catalytic residues [active] 698963001441 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 698963001442 Predicted permease [General function prediction only]; Region: COG2985 698963001443 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698963001444 TrkA-C domain; Region: TrkA_C; pfam02080 698963001445 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698963001446 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698963001447 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 698963001448 Glycoprotease family; Region: Peptidase_M22; pfam00814 698963001449 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698963001450 Coenzyme A binding pocket [chemical binding]; other site 698963001451 UGMP family protein; Validated; Region: PRK09604 698963001452 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 698963001453 oligomerisation interface [polypeptide binding]; other site 698963001454 mobile loop; other site 698963001455 roof hairpin; other site 698963001456 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698963001457 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698963001458 ring oligomerisation interface [polypeptide binding]; other site 698963001459 ATP/Mg binding site [chemical binding]; other site 698963001460 stacking interactions; other site 698963001461 hinge regions; other site 698963001462 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 698963001463 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698963001464 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698963001465 DNA binding residues [nucleotide binding] 698963001466 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 698963001467 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698963001468 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 698963001469 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 698963001470 active site 698963001471 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 698963001472 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698963001473 phosphate binding site [ion binding]; other site 698963001474 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698963001475 siderophore binding site; other site 698963001476 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698963001477 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698963001478 dimer interface [polypeptide binding]; other site 698963001479 putative PBP binding regions; other site 698963001480 ABC-ATPase subunit interface; other site 698963001481 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698963001482 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698963001483 ABC-ATPase subunit interface; other site 698963001484 dimer interface [polypeptide binding]; other site 698963001485 putative PBP binding regions; other site 698963001486 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698963001487 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698963001488 Walker A/P-loop; other site 698963001489 ATP binding site [chemical binding]; other site 698963001490 Q-loop/lid; other site 698963001491 ABC transporter signature motif; other site 698963001492 Walker B; other site 698963001493 D-loop; other site 698963001494 H-loop/switch region; other site 698963001495 IucA / IucC family; Region: IucA_IucC; pfam04183 698963001496 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698963001497 IucA / IucC family; Region: IucA_IucC; pfam04183 698963001498 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698963001499 H+ Antiporter protein; Region: 2A0121; TIGR00900 698963001500 EamA-like transporter family; Region: EamA; pfam00892 698963001501 GMP synthase; Reviewed; Region: guaA; PRK00074 698963001502 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 698963001503 AMP/PPi binding site [chemical binding]; other site 698963001504 candidate oxyanion hole; other site 698963001505 catalytic triad [active] 698963001506 potential glutamine specificity residues [chemical binding]; other site 698963001507 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 698963001508 ATP Binding subdomain [chemical binding]; other site 698963001509 Ligand Binding sites [chemical binding]; other site 698963001510 Dimerization subdomain; other site 698963001511 PspC domain; Region: PspC; pfam04024 698963001512 PspC domain; Region: PspC; pfam04024 698963001513 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698963001514 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698963001515 ATP binding site [chemical binding]; other site 698963001516 Mg2+ binding site [ion binding]; other site 698963001517 G-X-G motif; other site 698963001518 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698963001519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698963001520 active site 698963001521 phosphorylation site [posttranslational modification] 698963001522 intermolecular recognition site; other site 698963001523 dimerization interface [polypeptide binding]; other site 698963001524 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698963001525 DNA binding residues [nucleotide binding] 698963001526 dimerization interface [polypeptide binding]; other site 698963001527 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698963001528 intersubunit interface [polypeptide binding]; other site 698963001529 DNA Polymerase Y-family; Region: PolY_like; cd03468 698963001530 active site 698963001531 DNA binding site [nucleotide binding] 698963001532 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 698963001533 putative dimer interface [polypeptide binding]; other site 698963001534 putative [2Fe-2S] cluster binding site [ion binding]; other site 698963001535 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698963001536 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698963001537 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698963001538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698963001539 dimer interface [polypeptide binding]; other site 698963001540 conserved gate region; other site 698963001541 ABC-ATPase subunit interface; other site 698963001542 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 698963001543 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 698963001544 Walker A/P-loop; other site 698963001545 ATP binding site [chemical binding]; other site 698963001546 Q-loop/lid; other site 698963001547 ABC transporter signature motif; other site 698963001548 Walker B; other site 698963001549 D-loop; other site 698963001550 H-loop/switch region; other site 698963001551 NIL domain; Region: NIL; cl09633 698963001552 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698963001553 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 698963001554 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698963001555 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 698963001556 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 698963001557 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 698963001558 active site 698963001559 PHP Thumb interface [polypeptide binding]; other site 698963001560 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698963001561 generic binding surface II; other site 698963001562 generic binding surface I; other site 698963001563 Uncharacterized conserved protein [Function unknown]; Region: COG3402 698963001564 Predicted membrane protein [Function unknown]; Region: COG3428 698963001565 Bacterial PH domain; Region: DUF304; pfam03703 698963001566 Bacterial PH domain; Region: DUF304; pfam03703 698963001567 Bacterial PH domain; Region: DUF304; pfam03703 698963001568 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698963001569 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698963001570 intersubunit interface [polypeptide binding]; other site 698963001571 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698963001572 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698963001573 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698963001574 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698963001575 dimer interface [polypeptide binding]; other site 698963001576 putative PBP binding regions; other site 698963001577 ABC-ATPase subunit interface; other site 698963001578 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698963001579 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698963001580 ABC-ATPase subunit interface; other site 698963001581 dimer interface [polypeptide binding]; other site 698963001582 putative PBP binding regions; other site 698963001583 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698963001584 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698963001585 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698963001586 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 698963001587 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 698963001588 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 698963001589 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 698963001590 homodimer interface [polypeptide binding]; other site 698963001591 NADP binding site [chemical binding]; other site 698963001592 substrate binding site [chemical binding]; other site 698963001593 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 698963001594 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698963001595 active site 698963001596 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 698963001597 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 698963001598 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698963001599 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698963001600 intersubunit interface [polypeptide binding]; other site 698963001601 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698963001602 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698963001603 ABC-ATPase subunit interface; other site 698963001604 dimer interface [polypeptide binding]; other site 698963001605 putative PBP binding regions; other site 698963001606 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 698963001607 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698963001608 Walker A/P-loop; other site 698963001609 ATP binding site [chemical binding]; other site 698963001610 Q-loop/lid; other site 698963001611 ABC transporter signature motif; other site 698963001612 Walker B; other site 698963001613 D-loop; other site 698963001614 H-loop/switch region; other site 698963001615 Htaa; Region: HtaA; pfam04213 698963001616 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 698963001617 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698963001618 homodimer interface [polypeptide binding]; other site 698963001619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698963001620 substrate-cofactor binding pocket; other site 698963001621 catalytic residue [active] 698963001622 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 698963001623 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 698963001624 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698963001625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698963001626 putative substrate translocation pore; other site 698963001627 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698963001628 putative catalytic site [active] 698963001629 putative metal binding site [ion binding]; other site 698963001630 putative phosphate binding site [ion binding]; other site 698963001631 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 698963001632 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 698963001633 active site 698963001634 HIGH motif; other site 698963001635 dimer interface [polypeptide binding]; other site 698963001636 KMSKS motif; other site 698963001637 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 698963001638 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698963001639 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698963001640 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698963001641 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698963001642 NlpC/P60 family; Region: NLPC_P60; pfam00877 698963001643 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698963001644 active site 698963001645 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698963001646 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698963001647 non-specific DNA binding site [nucleotide binding]; other site 698963001648 salt bridge; other site 698963001649 sequence-specific DNA binding site [nucleotide binding]; other site 698963001650 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698963001651 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 698963001652 metal binding site [ion binding]; metal-binding site 698963001653 putative dimer interface [polypeptide binding]; other site 698963001654 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 698963001655 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698963001656 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698963001657 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698963001658 pyruvate carboxylase; Reviewed; Region: PRK12999 698963001659 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698963001660 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698963001661 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698963001662 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698963001663 active site 698963001664 catalytic residues [active] 698963001665 metal binding site [ion binding]; metal-binding site 698963001666 homodimer binding site [polypeptide binding]; other site 698963001667 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698963001668 carboxyltransferase (CT) interaction site; other site 698963001669 biotinylation site [posttranslational modification]; other site 698963001670 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 698963001671 ADP-ribose binding site [chemical binding]; other site 698963001672 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 698963001673 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698963001674 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 698963001675 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698963001676 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698963001677 carboxyltransferase (CT) interaction site; other site 698963001678 biotinylation site [posttranslational modification]; other site 698963001679 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698963001680 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698963001681 active site residue [active] 698963001682 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698963001683 active site residue [active] 698963001684 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698963001685 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 698963001686 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 698963001687 active site 698963001688 dimer interface [polypeptide binding]; other site 698963001689 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 698963001690 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698963001691 substrate binding site [chemical binding]; other site 698963001692 dimer interface [polypeptide binding]; other site 698963001693 ATP binding site [chemical binding]; other site 698963001694 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698963001695 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698963001696 DNA binding site [nucleotide binding] 698963001697 domain linker motif; other site 698963001698 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 698963001699 dimerization interface [polypeptide binding]; other site 698963001700 putative ligand binding site [chemical binding]; other site 698963001701 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 698963001702 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698963001703 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698963001704 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698963001705 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698963001706 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698963001707 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698963001708 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 698963001709 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 698963001710 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 698963001711 ATP-grasp domain; Region: ATP-grasp; pfam02222 698963001712 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 698963001713 Uncharacterized conserved protein [Function unknown]; Region: COG1434 698963001714 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698963001715 putative active site [active] 698963001716 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 698963001717 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 698963001718 HupF/HypC family; Region: HupF_HypC; pfam01455 698963001719 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 698963001720 dimerization interface [polypeptide binding]; other site 698963001721 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 698963001722 ATP binding site [chemical binding]; other site 698963001723 Acylphosphatase; Region: Acylphosphatase; pfam00708 698963001724 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 698963001725 HypF finger; Region: zf-HYPF; pfam07503 698963001726 HypF finger; Region: zf-HYPF; pfam07503 698963001727 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 698963001728 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 698963001729 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698963001730 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 698963001731 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 698963001732 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 698963001733 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 698963001734 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 698963001735 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 698963001736 putative substrate-binding site; other site 698963001737 nickel binding site [ion binding]; other site 698963001738 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 698963001739 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 698963001740 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 698963001741 HupF/HypC family; Region: HupF_HypC; pfam01455 698963001742 TIGR03089 family protein; Region: TIGR03089 698963001743 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698963001744 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698963001745 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698963001746 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698963001747 active site 698963001748 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698963001749 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 698963001750 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 698963001751 active site 698963001752 Substrate binding site; other site 698963001753 Mg++ binding site; other site 698963001754 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698963001755 putative trimer interface [polypeptide binding]; other site 698963001756 putative CoA binding site [chemical binding]; other site 698963001757 Transcription factor WhiB; Region: Whib; pfam02467 698963001758 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 698963001759 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 698963001760 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 698963001761 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 698963001762 active site 698963001763 substrate binding site [chemical binding]; other site 698963001764 metal binding site [ion binding]; metal-binding site 698963001765 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 698963001766 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698963001767 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698963001768 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 698963001769 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 698963001770 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 698963001771 homotetramer interface [polypeptide binding]; other site 698963001772 ligand binding site [chemical binding]; other site 698963001773 catalytic site [active] 698963001774 NAD binding site [chemical binding]; other site 698963001775 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 698963001776 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 698963001777 TMP-binding site; other site 698963001778 ATP-binding site [chemical binding]; other site 698963001779 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698963001780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698963001781 active site 698963001782 phosphorylation site [posttranslational modification] 698963001783 intermolecular recognition site; other site 698963001784 dimerization interface [polypeptide binding]; other site 698963001785 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698963001786 DNA binding site [nucleotide binding] 698963001787 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698963001788 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698963001789 dimerization interface [polypeptide binding]; other site 698963001790 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698963001791 dimer interface [polypeptide binding]; other site 698963001792 phosphorylation site [posttranslational modification] 698963001793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698963001794 ATP binding site [chemical binding]; other site 698963001795 Mg2+ binding site [ion binding]; other site 698963001796 G-X-G motif; other site 698963001797 lipoprotein LpqB; Provisional; Region: PRK13616 698963001798 Sporulation and spore germination; Region: Germane; pfam10646 698963001799 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 698963001800 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698963001801 active site 698963001802 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 698963001803 30S subunit binding site; other site 698963001804 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 698963001805 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698963001806 ATP binding site [chemical binding]; other site 698963001807 putative Mg++ binding site [ion binding]; other site 698963001808 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 698963001809 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698963001810 nucleotide binding region [chemical binding]; other site 698963001811 ATP-binding site [chemical binding]; other site 698963001812 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 698963001813 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 698963001814 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698963001815 FAD binding pocket [chemical binding]; other site 698963001816 FAD binding motif [chemical binding]; other site 698963001817 phosphate binding motif [ion binding]; other site 698963001818 beta-alpha-beta structure motif; other site 698963001819 NAD binding pocket [chemical binding]; other site 698963001820 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698963001821 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 698963001822 catalytic loop [active] 698963001823 iron binding site [ion binding]; other site 698963001824 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 698963001825 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 698963001826 putative di-iron ligands [ion binding]; other site 698963001827 Predicted GTPases [General function prediction only]; Region: COG1162 698963001828 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 698963001829 GTPase/Zn-binding domain interface [polypeptide binding]; other site 698963001830 GTP/Mg2+ binding site [chemical binding]; other site 698963001831 G4 box; other site 698963001832 G5 box; other site 698963001833 G1 box; other site 698963001834 Switch I region; other site 698963001835 G2 box; other site 698963001836 G3 box; other site 698963001837 Switch II region; other site 698963001838 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 698963001839 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 698963001840 hinge; other site 698963001841 active site 698963001842 Uncharacterized conserved protein [Function unknown]; Region: COG2135 698963001843 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 698963001844 putative deacylase active site [active] 698963001845 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 698963001846 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698963001847 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698963001848 DNA binding residues [nucleotide binding] 698963001849 Transcription factor WhiB; Region: Whib; pfam02467 698963001850 PQQ-like domain; Region: PQQ_2; pfam13360 698963001851 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698963001852 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698963001853 ATP binding site [chemical binding]; other site 698963001854 Mg++ binding site [ion binding]; other site 698963001855 motif III; other site 698963001856 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698963001857 nucleotide binding region [chemical binding]; other site 698963001858 ATP-binding site [chemical binding]; other site 698963001859 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 698963001860 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 698963001861 TIGR02569 family protein; Region: TIGR02569_actnb 698963001862 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698963001863 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698963001864 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698963001865 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698963001866 Part of AAA domain; Region: AAA_19; pfam13245 698963001867 Family description; Region: UvrD_C_2; pfam13538 698963001868 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698963001869 Ion channel; Region: Ion_trans_2; pfam07885 698963001870 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 698963001871 TrkA-N domain; Region: TrkA_N; pfam02254 698963001872 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 698963001873 putative NADH binding site [chemical binding]; other site 698963001874 putative active site [active] 698963001875 nudix motif; other site 698963001876 putative metal binding site [ion binding]; other site 698963001877 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698963001878 Part of AAA domain; Region: AAA_19; pfam13245 698963001879 Family description; Region: UvrD_C_2; pfam13538 698963001880 HRDC domain; Region: HRDC; pfam00570 698963001881 Protein of unknown function DUF45; Region: DUF45; pfam01863 698963001882 putative hydrolase; Region: TIGR03624 698963001883 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 698963001884 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698963001885 hypothetical protein; Validated; Region: PRK00068 698963001886 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 698963001887 potential frameshift: common BLAST hit: gi|172041460|ref|YP_001801174.1| sodium/glutamate symporter 698963001888 potential frameshift: common BLAST hit: gi|172041460|ref|YP_001801174.1| sodium/glutamate symporter 698963001889 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698963001890 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698963001891 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 698963001892 active site 698963001893 oxaloacetate decarboxylase; Provisional; Region: PRK12330 698963001894 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698963001895 active site 698963001896 catalytic residues [active] 698963001897 metal binding site [ion binding]; metal-binding site 698963001898 homodimer binding site [polypeptide binding]; other site 698963001899 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 698963001900 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698963001901 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698963001902 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698963001903 carboxyltransferase (CT) interaction site; other site 698963001904 biotinylation site [posttranslational modification]; other site 698963001905 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698963001906 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 698963001907 active site 698963001908 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698963001909 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698963001910 active site 698963001911 peptide chain release factor 2; Validated; Region: prfB; PRK00578 698963001912 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698963001913 RF-1 domain; Region: RF-1; pfam00472 698963001914 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 698963001915 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698963001916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963001917 Walker A/P-loop; other site 698963001918 ATP binding site [chemical binding]; other site 698963001919 Q-loop/lid; other site 698963001920 ABC transporter signature motif; other site 698963001921 Walker B; other site 698963001922 D-loop; other site 698963001923 H-loop/switch region; other site 698963001924 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 698963001925 FtsX-like permease family; Region: FtsX; pfam02687 698963001926 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 698963001927 SmpB-tmRNA interface; other site 698963001928 Cupin domain; Region: Cupin_2; cl17218 698963001929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698963001930 S-adenosylmethionine binding site [chemical binding]; other site 698963001931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698963001932 Winged helix-turn helix; Region: HTH_29; pfam13551 698963001933 Helix-turn-helix domain; Region: HTH_28; pfam13518 698963001934 Integrase core domain; Region: rve; pfam00665 698963001935 Integrase core domain; Region: rve_2; pfam13333 698963001936 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698963001937 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698963001938 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698963001939 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698963001940 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698963001941 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698963001942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698963001943 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 698963001944 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698963001945 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698963001946 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698963001947 nucleotide binding region [chemical binding]; other site 698963001948 ATP-binding site [chemical binding]; other site 698963001949 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698963001950 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698963001951 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 698963001952 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698963001953 DNA-binding site [nucleotide binding]; DNA binding site 698963001954 RNA-binding motif; other site 698963001955 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 698963001956 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 698963001957 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 698963001958 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 698963001959 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698963001960 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698963001961 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 698963001962 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698963001963 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698963001964 catalytic residue [active] 698963001965 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 698963001966 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 698963001967 dimer interface [polypeptide binding]; other site 698963001968 active site 698963001969 citrylCoA binding site [chemical binding]; other site 698963001970 NADH binding [chemical binding]; other site 698963001971 cationic pore residues; other site 698963001972 oxalacetate/citrate binding site [chemical binding]; other site 698963001973 coenzyme A binding site [chemical binding]; other site 698963001974 catalytic triad [active] 698963001975 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698963001976 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 698963001977 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698963001978 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698963001979 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698963001980 active site 698963001981 catalytic tetrad [active] 698963001982 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 698963001983 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698963001984 substrate binding site [chemical binding]; other site 698963001985 oxyanion hole (OAH) forming residues; other site 698963001986 trimer interface [polypeptide binding]; other site 698963001987 Protein of unknown function, DUF485; Region: DUF485; pfam04341 698963001988 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698963001989 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 698963001990 Na binding site [ion binding]; other site 698963001991 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 698963001992 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 698963001993 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698963001994 Fic/DOC family; Region: Fic; cl00960 698963001995 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 698963001996 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 698963001997 active site 698963001998 SAM binding site [chemical binding]; other site 698963001999 homodimer interface [polypeptide binding]; other site 698963002000 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698963002001 catalytic residues [active] 698963002002 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 698963002003 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 698963002004 folate binding site [chemical binding]; other site 698963002005 NADP+ binding site [chemical binding]; other site 698963002006 thymidylate synthase; Reviewed; Region: thyA; PRK01827 698963002007 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 698963002008 dimerization interface [polypeptide binding]; other site 698963002009 active site 698963002010 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 698963002011 active site 698963002012 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698963002013 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 698963002014 ATP binding site [chemical binding]; other site 698963002015 putative Mg++ binding site [ion binding]; other site 698963002016 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698963002017 nucleotide binding region [chemical binding]; other site 698963002018 ATP-binding site [chemical binding]; other site 698963002019 DEAD/H associated; Region: DEAD_assoc; pfam08494 698963002020 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 698963002021 active site 698963002022 SUMO-1 interface [polypeptide binding]; other site 698963002023 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698963002024 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 698963002025 putative DNA binding site [nucleotide binding]; other site 698963002026 catalytic residue [active] 698963002027 putative H2TH interface [polypeptide binding]; other site 698963002028 putative catalytic residues [active] 698963002029 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698963002030 Predicted permease [General function prediction only]; Region: COG2985 698963002031 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698963002032 TrkA-C domain; Region: TrkA_C; pfam02080 698963002033 TrkA-C domain; Region: TrkA_C; pfam02080 698963002034 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698963002035 hypothetical protein; Provisional; Region: PRK11770 698963002036 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698963002037 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698963002038 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 698963002039 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 698963002040 active site 698963002041 dimer interface [polypeptide binding]; other site 698963002042 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 698963002043 dimer interface [polypeptide binding]; other site 698963002044 active site 698963002045 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698963002046 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698963002047 tetramerization interface [polypeptide binding]; other site 698963002048 NAD(P) binding site [chemical binding]; other site 698963002049 catalytic residues [active] 698963002050 hypothetical protein; Provisional; Region: PRK07857 698963002051 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 698963002052 Part of AAA domain; Region: AAA_19; pfam13245 698963002053 Family description; Region: UvrD_C_2; pfam13538 698963002054 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698963002055 Peptidase family M23; Region: Peptidase_M23; pfam01551 698963002056 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 698963002057 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 698963002058 active site 698963002059 substrate binding site [chemical binding]; other site 698963002060 cosubstrate binding site; other site 698963002061 catalytic site [active] 698963002062 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 698963002063 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 698963002064 purine monophosphate binding site [chemical binding]; other site 698963002065 dimer interface [polypeptide binding]; other site 698963002066 putative catalytic residues [active] 698963002067 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 698963002068 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 698963002069 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698963002070 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698963002071 Domain of unknown function (DUF2014); Region: DUF2014; pfam09427 698963002072 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 698963002073 30S ribosomal protein S18; Provisional; Region: PRK13401 698963002074 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 698963002075 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 698963002076 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 698963002077 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 698963002078 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 698963002079 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698963002080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698963002081 active site 698963002082 phosphorylation site [posttranslational modification] 698963002083 intermolecular recognition site; other site 698963002084 dimerization interface [polypeptide binding]; other site 698963002085 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698963002086 DNA binding site [nucleotide binding] 698963002087 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698963002088 dimerization interface [polypeptide binding]; other site 698963002089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698963002090 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698963002091 dimer interface [polypeptide binding]; other site 698963002092 phosphorylation site [posttranslational modification] 698963002093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698963002094 ATP binding site [chemical binding]; other site 698963002095 Mg2+ binding site [ion binding]; other site 698963002096 G-X-G motif; other site 698963002097 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698963002098 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698963002099 protein binding site [polypeptide binding]; other site 698963002100 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698963002101 MPT binding site; other site 698963002102 trimer interface [polypeptide binding]; other site 698963002103 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 698963002104 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 698963002105 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 698963002106 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 698963002107 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 698963002108 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 698963002109 active site 698963002110 tetramer interface; other site 698963002111 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698963002112 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698963002113 dimer interface [polypeptide binding]; other site 698963002114 putative functional site; other site 698963002115 putative MPT binding site; other site 698963002116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698963002117 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698963002118 Predicted membrane protein [Function unknown]; Region: COG2259 698963002119 Predicted integral membrane protein [Function unknown]; Region: COG5660 698963002120 Putative zinc-finger; Region: zf-HC2; pfam13490 698963002121 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 698963002122 BCCT family transporter; Region: BCCT; pfam02028 698963002123 Uncharacterized membrane protein [Function unknown]; Region: COG3949 698963002124 Predicted methyltransferases [General function prediction only]; Region: COG0313 698963002125 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 698963002126 putative SAM binding site [chemical binding]; other site 698963002127 putative homodimer interface [polypeptide binding]; other site 698963002128 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 698963002129 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 698963002130 active site 698963002131 HIGH motif; other site 698963002132 KMSKS motif; other site 698963002133 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 698963002134 tRNA binding surface [nucleotide binding]; other site 698963002135 anticodon binding site; other site 698963002136 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 698963002137 active site 698963002138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 698963002139 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698963002140 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698963002141 G5 domain; Region: G5; pfam07501 698963002142 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698963002143 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 698963002144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698963002145 S-adenosylmethionine binding site [chemical binding]; other site 698963002146 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 698963002147 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698963002148 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698963002149 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698963002150 ABC transporter; Region: ABC_tran_2; pfam12848 698963002151 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698963002152 Uncharacterized conserved protein [Function unknown]; Region: COG1359 698963002153 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698963002154 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698963002155 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698963002156 DNA binding residues [nucleotide binding] 698963002157 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698963002158 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 698963002159 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698963002160 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698963002161 active site 698963002162 motif I; other site 698963002163 motif II; other site 698963002164 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698963002165 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 698963002166 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698963002167 substrate binding site [chemical binding]; other site 698963002168 oxyanion hole (OAH) forming residues; other site 698963002169 trimer interface [polypeptide binding]; other site 698963002170 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 698963002171 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698963002172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698963002173 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 698963002174 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 698963002175 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698963002176 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 698963002177 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 698963002178 G1 box; other site 698963002179 putative GEF interaction site [polypeptide binding]; other site 698963002180 GTP/Mg2+ binding site [chemical binding]; other site 698963002181 Switch I region; other site 698963002182 G2 box; other site 698963002183 G3 box; other site 698963002184 Switch II region; other site 698963002185 G4 box; other site 698963002186 G5 box; other site 698963002187 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 698963002188 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 698963002189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698963002190 NAD(P) binding site [chemical binding]; other site 698963002191 active site 698963002192 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698963002193 putative active site [active] 698963002194 catalytic residue [active] 698963002195 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698963002196 active site 698963002197 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698963002198 putative active site [active] 698963002199 catalytic residue [active] 698963002200 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 698963002201 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 698963002202 5S rRNA interface [nucleotide binding]; other site 698963002203 CTC domain interface [polypeptide binding]; other site 698963002204 L16 interface [polypeptide binding]; other site 698963002205 pullulanase, type I; Region: pulA_typeI; TIGR02104 698963002206 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 698963002207 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 698963002208 Ca binding site [ion binding]; other site 698963002209 active site 698963002210 catalytic site [active] 698963002211 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 698963002212 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 698963002213 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698963002214 active site 698963002215 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 698963002216 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 698963002217 Substrate binding site; other site 698963002218 Mg++ binding site; other site 698963002219 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 698963002220 active site 698963002221 substrate binding site [chemical binding]; other site 698963002222 CoA binding site [chemical binding]; other site 698963002223 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698963002224 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698963002225 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 698963002226 putative dimerization interface [polypeptide binding]; other site 698963002227 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 698963002228 gating phenylalanine in ion channel; other site 698963002229 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698963002230 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 698963002231 putative ligand binding site [chemical binding]; other site 698963002232 putative NAD binding site [chemical binding]; other site 698963002233 catalytic site [active] 698963002234 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698963002235 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698963002236 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963002237 Q-loop/lid; other site 698963002238 ABC transporter signature motif; other site 698963002239 Walker B; other site 698963002240 D-loop; other site 698963002241 H-loop/switch region; other site 698963002242 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698963002243 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698963002244 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963002245 Walker A/P-loop; other site 698963002246 ATP binding site [chemical binding]; other site 698963002247 Q-loop/lid; other site 698963002248 ABC transporter signature motif; other site 698963002249 Walker B; other site 698963002250 D-loop; other site 698963002251 H-loop/switch region; other site 698963002252 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698963002253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698963002254 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 698963002255 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 698963002256 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698963002257 ATP binding site [chemical binding]; other site 698963002258 putative Mg++ binding site [ion binding]; other site 698963002259 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698963002260 nucleotide binding region [chemical binding]; other site 698963002261 ATP-binding site [chemical binding]; other site 698963002262 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 698963002263 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 698963002264 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 698963002265 homodimer interface [polypeptide binding]; other site 698963002266 metal binding site [ion binding]; metal-binding site 698963002267 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 698963002268 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698963002269 enolase; Provisional; Region: eno; PRK00077 698963002270 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 698963002271 dimer interface [polypeptide binding]; other site 698963002272 metal binding site [ion binding]; metal-binding site 698963002273 substrate binding pocket [chemical binding]; other site 698963002274 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 698963002275 Septum formation initiator; Region: DivIC; pfam04977 698963002276 Uncharacterized conserved protein [Function unknown]; Region: COG1507 698963002277 exopolyphosphatase; Region: exo_poly_only; TIGR03706 698963002278 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698963002279 potential frameshift: common BLAST hit: gi|38233440|ref|NP_939207.1| transposase 698963002280 Integrase core domain; Region: rve_2; pfam13333 698963002281 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698963002282 HTH-like domain; Region: HTH_21; pfam13276 698963002283 Integrase core domain; Region: rve; pfam00665 698963002284 Helix-turn-helix domain; Region: HTH_18; pfam12833 698963002285 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698963002286 Bax inhibitor 1 like; Region: BaxI_1; cl17691 698963002287 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 698963002288 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 698963002289 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 698963002290 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 698963002291 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 698963002292 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 698963002293 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698963002294 catalytic residue [active] 698963002295 putative FPP diphosphate binding site; other site 698963002296 putative FPP binding hydrophobic cleft; other site 698963002297 dimer interface [polypeptide binding]; other site 698963002298 putative IPP diphosphate binding site; other site 698963002299 Flavodoxin domain; Region: Flavodoxin_5; cl17428 698963002300 pantothenate kinase; Provisional; Region: PRK05439 698963002301 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 698963002302 ATP-binding site [chemical binding]; other site 698963002303 CoA-binding site [chemical binding]; other site 698963002304 Mg2+-binding site [ion binding]; other site 698963002305 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 698963002306 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 698963002307 dimer interface [polypeptide binding]; other site 698963002308 active site 698963002309 glycine-pyridoxal phosphate binding site [chemical binding]; other site 698963002310 folate binding site [chemical binding]; other site 698963002311 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698963002312 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 698963002313 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698963002314 Coenzyme A binding pocket [chemical binding]; other site 698963002315 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698963002316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698963002317 putative substrate translocation pore; other site 698963002318 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698963002319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698963002320 fumarate hydratase; Reviewed; Region: fumC; PRK00485 698963002321 Class II fumarases; Region: Fumarase_classII; cd01362 698963002322 active site 698963002323 tetramer interface [polypeptide binding]; other site 698963002324 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 698963002325 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 698963002326 putative active site [active] 698963002327 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 698963002328 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 698963002329 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 698963002330 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 698963002331 generic binding surface II; other site 698963002332 generic binding surface I; other site 698963002333 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 698963002334 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 698963002335 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698963002336 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698963002337 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 698963002338 Na2 binding site [ion binding]; other site 698963002339 putative substrate binding site 1 [chemical binding]; other site 698963002340 Na binding site 1 [ion binding]; other site 698963002341 putative substrate binding site 2 [chemical binding]; other site 698963002342 GTP-binding protein YchF; Reviewed; Region: PRK09601 698963002343 YchF GTPase; Region: YchF; cd01900 698963002344 G1 box; other site 698963002345 GTP/Mg2+ binding site [chemical binding]; other site 698963002346 Switch I region; other site 698963002347 G2 box; other site 698963002348 Switch II region; other site 698963002349 G3 box; other site 698963002350 G4 box; other site 698963002351 G5 box; other site 698963002352 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 698963002353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 698963002354 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 698963002355 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 698963002356 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 698963002357 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 698963002358 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 698963002359 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 698963002360 Cl- selectivity filter; other site 698963002361 Cl- binding residues [ion binding]; other site 698963002362 pore gating glutamate residue; other site 698963002363 dimer interface [polypeptide binding]; other site 698963002364 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698963002365 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698963002366 Walker A/P-loop; other site 698963002367 ATP binding site [chemical binding]; other site 698963002368 Q-loop/lid; other site 698963002369 ABC transporter signature motif; other site 698963002370 Walker B; other site 698963002371 D-loop; other site 698963002372 H-loop/switch region; other site 698963002373 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 698963002374 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698963002375 Walker A/P-loop; other site 698963002376 ATP binding site [chemical binding]; other site 698963002377 Q-loop/lid; other site 698963002378 ABC transporter signature motif; other site 698963002379 Walker B; other site 698963002380 D-loop; other site 698963002381 H-loop/switch region; other site 698963002382 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698963002383 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 698963002384 active site 698963002385 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698963002386 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698963002387 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698963002388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698963002389 dimer interface [polypeptide binding]; other site 698963002390 conserved gate region; other site 698963002391 ABC-ATPase subunit interface; other site 698963002392 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698963002393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698963002394 dimer interface [polypeptide binding]; other site 698963002395 conserved gate region; other site 698963002396 putative PBP binding loops; other site 698963002397 ABC-ATPase subunit interface; other site 698963002398 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698963002399 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698963002400 Walker A/P-loop; other site 698963002401 ATP binding site [chemical binding]; other site 698963002402 Q-loop/lid; other site 698963002403 ABC transporter signature motif; other site 698963002404 Walker B; other site 698963002405 D-loop; other site 698963002406 H-loop/switch region; other site 698963002407 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698963002408 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698963002409 Walker A/P-loop; other site 698963002410 ATP binding site [chemical binding]; other site 698963002411 Q-loop/lid; other site 698963002412 ABC transporter signature motif; other site 698963002413 Walker B; other site 698963002414 D-loop; other site 698963002415 H-loop/switch region; other site 698963002416 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698963002417 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698963002418 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963002419 Walker A/P-loop; other site 698963002420 ATP binding site [chemical binding]; other site 698963002421 ABC transporter signature motif; other site 698963002422 Walker B; other site 698963002423 D-loop; other site 698963002424 H-loop/switch region; other site 698963002425 Trypsin; Region: Trypsin; pfam00089 698963002426 active site 698963002427 substrate binding sites [chemical binding]; other site 698963002428 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 698963002429 ArsC family; Region: ArsC; pfam03960 698963002430 catalytic residues [active] 698963002431 Protein of unknown function (DUF402); Region: DUF402; cl00979 698963002432 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 698963002433 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 698963002434 G1 box; other site 698963002435 GTP/Mg2+ binding site [chemical binding]; other site 698963002436 G2 box; other site 698963002437 Switch I region; other site 698963002438 G3 box; other site 698963002439 Switch II region; other site 698963002440 G4 box; other site 698963002441 G5 box; other site 698963002442 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 698963002443 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 698963002444 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 698963002445 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698963002446 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 698963002447 Ferredoxin [Energy production and conversion]; Region: COG1146 698963002448 4Fe-4S binding domain; Region: Fer4; pfam00037 698963002449 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 698963002450 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698963002451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698963002452 homodimer interface [polypeptide binding]; other site 698963002453 catalytic residue [active] 698963002454 Predicted membrane protein [Function unknown]; Region: COG2246 698963002455 GtrA-like protein; Region: GtrA; pfam04138 698963002456 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698963002457 active site 698963002458 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 698963002459 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698963002460 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 698963002461 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 698963002462 putative trimer interface [polypeptide binding]; other site 698963002463 putative CoA binding site [chemical binding]; other site 698963002464 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 698963002465 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698963002466 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 698963002467 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698963002468 putative trimer interface [polypeptide binding]; other site 698963002469 putative CoA binding site [chemical binding]; other site 698963002470 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 698963002471 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 698963002472 metal binding site [ion binding]; metal-binding site 698963002473 putative dimer interface [polypeptide binding]; other site 698963002474 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698963002475 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698963002476 dihydropteroate synthase; Region: DHPS; TIGR01496 698963002477 substrate binding pocket [chemical binding]; other site 698963002478 dimer interface [polypeptide binding]; other site 698963002479 inhibitor binding site; inhibition site 698963002480 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 698963002481 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 698963002482 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 698963002483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698963002484 S-adenosylmethionine binding site [chemical binding]; other site 698963002485 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 698963002486 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 698963002487 active site 698963002488 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 698963002489 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 698963002490 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 698963002491 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698963002492 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 698963002493 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 698963002494 ligand binding site; other site 698963002495 oligomer interface; other site 698963002496 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 698963002497 dimer interface [polypeptide binding]; other site 698963002498 N-terminal domain interface [polypeptide binding]; other site 698963002499 sulfate 1 binding site; other site 698963002500 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 698963002501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698963002502 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 698963002503 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698963002504 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698963002505 DNA binding residues [nucleotide binding] 698963002506 Putative zinc-finger; Region: zf-HC2; pfam13490 698963002507 sec-independent translocase; Provisional; Region: tatB; PRK00182 698963002508 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 698963002509 Domain of unknown function DUF59; Region: DUF59; pfam01883 698963002510 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 698963002511 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 698963002512 Predicted membrane protein [Function unknown]; Region: COG4420 698963002513 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 698963002514 MgtE intracellular N domain; Region: MgtE_N; smart00924 698963002515 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 698963002516 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 698963002517 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698963002518 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 698963002519 TPP-binding site [chemical binding]; other site 698963002520 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 698963002521 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698963002522 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698963002523 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963002524 Walker A/P-loop; other site 698963002525 ATP binding site [chemical binding]; other site 698963002526 Q-loop/lid; other site 698963002527 ABC transporter signature motif; other site 698963002528 Walker B; other site 698963002529 D-loop; other site 698963002530 H-loop/switch region; other site 698963002531 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698963002532 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698963002533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963002534 Walker A/P-loop; other site 698963002535 ATP binding site [chemical binding]; other site 698963002536 Q-loop/lid; other site 698963002537 ABC transporter signature motif; other site 698963002538 Walker B; other site 698963002539 D-loop; other site 698963002540 H-loop/switch region; other site 698963002541 Transposase; Region: DDE_Tnp_ISL3; pfam01610 698963002542 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 698963002543 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698963002544 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698963002545 shikimate binding site; other site 698963002546 NAD(P) binding site [chemical binding]; other site 698963002547 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698963002548 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698963002549 substrate binding pocket [chemical binding]; other site 698963002550 catalytic triad [active] 698963002551 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 698963002552 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 698963002553 active site 698963002554 catalytic residues [active] 698963002555 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 698963002556 putative transporter; Provisional; Region: PRK10484 698963002557 Na binding site [ion binding]; other site 698963002558 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698963002559 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 698963002560 nucleotide binding site/active site [active] 698963002561 HIT family signature motif; other site 698963002562 catalytic residue [active] 698963002563 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 698963002564 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698963002565 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698963002566 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698963002567 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 698963002568 PLD-like domain; Region: PLDc_2; pfam13091 698963002569 putative homodimer interface [polypeptide binding]; other site 698963002570 putative active site [active] 698963002571 catalytic site [active] 698963002572 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698963002573 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698963002574 putative Mg++ binding site [ion binding]; other site 698963002575 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698963002576 nucleotide binding region [chemical binding]; other site 698963002577 ATP-binding site [chemical binding]; other site 698963002578 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 698963002579 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 698963002580 active site 698963002581 8-oxo-dGMP binding site [chemical binding]; other site 698963002582 nudix motif; other site 698963002583 metal binding site [ion binding]; metal-binding site 698963002584 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 698963002585 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698963002586 ATP binding site [chemical binding]; other site 698963002587 Mg++ binding site [ion binding]; other site 698963002588 motif III; other site 698963002589 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698963002590 nucleotide binding region [chemical binding]; other site 698963002591 ATP-binding site [chemical binding]; other site 698963002592 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 698963002593 putative RNA binding site [nucleotide binding]; other site 698963002594 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698963002595 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698963002596 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 698963002597 Na binding site [ion binding]; other site 698963002598 SNF2 Helicase protein; Region: DUF3670; pfam12419 698963002599 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 698963002600 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698963002601 ATP binding site [chemical binding]; other site 698963002602 putative Mg++ binding site [ion binding]; other site 698963002603 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698963002604 nucleotide binding region [chemical binding]; other site 698963002605 ATP-binding site [chemical binding]; other site 698963002606 Uncharacterized conserved protein [Function unknown]; Region: COG4279 698963002607 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 698963002608 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 698963002609 active site 698963002610 metal binding site [ion binding]; metal-binding site 698963002611 DNA binding site [nucleotide binding] 698963002612 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 698963002613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963002614 Walker A/P-loop; other site 698963002615 ATP binding site [chemical binding]; other site 698963002616 Q-loop/lid; other site 698963002617 Uncharacterized conserved protein [Function unknown]; Region: COG2353 698963002618 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698963002619 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 698963002620 PspC domain; Region: PspC; cl00864 698963002621 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 698963002622 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698963002623 dimerization interface [polypeptide binding]; other site 698963002624 putative DNA binding site [nucleotide binding]; other site 698963002625 putative Zn2+ binding site [ion binding]; other site 698963002626 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 698963002627 Cadmium resistance transporter; Region: Cad; pfam03596 698963002628 putative transposase OrfB; Reviewed; Region: PHA02517 698963002629 HTH-like domain; Region: HTH_21; pfam13276 698963002630 Integrase core domain; Region: rve; pfam00665 698963002631 Integrase core domain; Region: rve_2; pfam13333 698963002632 Homeodomain-like domain; Region: HTH_23; cl17451 698963002633 Helix-turn-helix domain; Region: HTH_28; pfam13518 698963002634 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698963002635 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 698963002636 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698963002637 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 698963002638 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698963002639 Cysteine-rich domain; Region: CCG; pfam02754 698963002640 Cysteine-rich domain; Region: CCG; pfam02754 698963002641 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698963002642 L-lactate permease; Region: Lactate_perm; cl00701 698963002643 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 698963002644 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 698963002645 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 698963002646 active site 698963002647 HIGH motif; other site 698963002648 KMSK motif region; other site 698963002649 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 698963002650 tRNA binding surface [nucleotide binding]; other site 698963002651 anticodon binding site; other site 698963002652 diaminopimelate decarboxylase; Region: lysA; TIGR01048 698963002653 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 698963002654 active site 698963002655 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698963002656 substrate binding site [chemical binding]; other site 698963002657 catalytic residues [active] 698963002658 dimer interface [polypeptide binding]; other site 698963002659 homoserine dehydrogenase; Provisional; Region: PRK06349 698963002660 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 698963002661 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 698963002662 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 698963002663 homoserine kinase; Provisional; Region: PRK01212 698963002664 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 698963002665 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698963002666 acyl-activating enzyme (AAE) consensus motif; other site 698963002667 AMP binding site [chemical binding]; other site 698963002668 active site 698963002669 CoA binding site [chemical binding]; other site 698963002670 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 698963002671 transcription termination factor Rho; Provisional; Region: PRK12608 698963002672 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698963002673 RNA binding site [nucleotide binding]; other site 698963002674 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 698963002675 multimer interface [polypeptide binding]; other site 698963002676 Walker A motif; other site 698963002677 ATP binding site [chemical binding]; other site 698963002678 Walker B motif; other site 698963002679 peptide chain release factor 1; Validated; Region: prfA; PRK00591 698963002680 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698963002681 RF-1 domain; Region: RF-1; pfam00472 698963002682 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 698963002683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698963002684 S-adenosylmethionine binding site [chemical binding]; other site 698963002685 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 698963002686 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 698963002687 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 698963002688 Mg++ binding site [ion binding]; other site 698963002689 putative catalytic motif [active] 698963002690 substrate binding site [chemical binding]; other site 698963002691 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 698963002692 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 698963002693 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 698963002694 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 698963002695 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 698963002696 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 698963002697 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 698963002698 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 698963002699 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698963002700 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 698963002701 beta subunit interaction interface [polypeptide binding]; other site 698963002702 Walker A motif; other site 698963002703 ATP binding site [chemical binding]; other site 698963002704 Walker B motif; other site 698963002705 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698963002706 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 698963002707 core domain interface [polypeptide binding]; other site 698963002708 delta subunit interface [polypeptide binding]; other site 698963002709 epsilon subunit interface [polypeptide binding]; other site 698963002710 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 698963002711 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698963002712 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 698963002713 alpha subunit interaction interface [polypeptide binding]; other site 698963002714 Walker A motif; other site 698963002715 ATP binding site [chemical binding]; other site 698963002716 Walker B motif; other site 698963002717 inhibitor binding site; inhibition site 698963002718 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698963002719 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 698963002720 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 698963002721 gamma subunit interface [polypeptide binding]; other site 698963002722 epsilon subunit interface [polypeptide binding]; other site 698963002723 LBP interface [polypeptide binding]; other site 698963002724 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 698963002725 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 698963002726 hypothetical protein; Provisional; Region: PRK03298 698963002727 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 698963002728 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698963002729 dimer interface [polypeptide binding]; other site 698963002730 substrate binding site [chemical binding]; other site 698963002731 metal binding site [ion binding]; metal-binding site 698963002732 Domain of unknown function DUF77; Region: DUF77; pfam01910 698963002733 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698963002734 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698963002735 Walker A/P-loop; other site 698963002736 ATP binding site [chemical binding]; other site 698963002737 Q-loop/lid; other site 698963002738 ABC transporter signature motif; other site 698963002739 Walker B; other site 698963002740 D-loop; other site 698963002741 H-loop/switch region; other site 698963002742 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698963002743 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698963002744 ABC-ATPase subunit interface; other site 698963002745 dimer interface [polypeptide binding]; other site 698963002746 putative PBP binding regions; other site 698963002747 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698963002748 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698963002749 ABC-ATPase subunit interface; other site 698963002750 dimer interface [polypeptide binding]; other site 698963002751 putative PBP binding regions; other site 698963002752 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 698963002753 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698963002754 siderophore binding site; other site 698963002755 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 698963002756 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 698963002757 glycogen branching enzyme; Provisional; Region: PRK05402 698963002758 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 698963002759 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 698963002760 active site 698963002761 catalytic site [active] 698963002762 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 698963002763 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 698963002764 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 698963002765 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698963002766 active site 698963002767 homodimer interface [polypeptide binding]; other site 698963002768 catalytic site [active] 698963002769 acceptor binding site [chemical binding]; other site 698963002770 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698963002771 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963002772 Walker A/P-loop; other site 698963002773 ATP binding site [chemical binding]; other site 698963002774 Q-loop/lid; other site 698963002775 ABC transporter signature motif; other site 698963002776 Walker B; other site 698963002777 D-loop; other site 698963002778 H-loop/switch region; other site 698963002779 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 698963002780 Ligand binding site [chemical binding]; other site 698963002781 Electron transfer flavoprotein domain; Region: ETF; pfam01012 698963002782 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 698963002783 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 698963002784 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 698963002785 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 698963002786 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 698963002787 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698963002788 catalytic residue [active] 698963002789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698963002790 S-adenosylmethionine binding site [chemical binding]; other site 698963002791 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 698963002792 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 698963002793 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698963002794 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698963002795 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698963002796 active site 698963002797 catalytic site [active] 698963002798 substrate binding site [chemical binding]; other site 698963002799 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 698963002800 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 698963002801 nucleotide binding pocket [chemical binding]; other site 698963002802 K-X-D-G motif; other site 698963002803 catalytic site [active] 698963002804 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 698963002805 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 698963002806 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 698963002807 Dimer interface [polypeptide binding]; other site 698963002808 BRCT sequence motif; other site 698963002809 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698963002810 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 698963002811 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698963002812 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 698963002813 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 698963002814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698963002815 Coenzyme A binding pocket [chemical binding]; other site 698963002816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698963002817 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698963002818 putative substrate translocation pore; other site 698963002819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698963002820 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698963002821 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698963002822 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698963002823 ABC-ATPase subunit interface; other site 698963002824 dimer interface [polypeptide binding]; other site 698963002825 putative PBP binding regions; other site 698963002826 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698963002827 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963002828 Walker A/P-loop; other site 698963002829 ATP binding site [chemical binding]; other site 698963002830 Q-loop/lid; other site 698963002831 ABC transporter signature motif; other site 698963002832 Walker B; other site 698963002833 D-loop; other site 698963002834 H-loop/switch region; other site 698963002835 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 698963002836 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 698963002837 putative ligand binding residues [chemical binding]; other site 698963002838 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 698963002839 phosphofructokinase; Region: PFK_mixed; TIGR02483 698963002840 active site 698963002841 ADP/pyrophosphate binding site [chemical binding]; other site 698963002842 dimerization interface [polypeptide binding]; other site 698963002843 allosteric effector site; other site 698963002844 fructose-1,6-bisphosphate binding site; other site 698963002845 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 698963002846 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 698963002847 GatB domain; Region: GatB_Yqey; smart00845 698963002848 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698963002849 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698963002850 active site 698963002851 catalytic tetrad [active] 698963002852 Lysine efflux permease [General function prediction only]; Region: COG1279 698963002853 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 698963002854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698963002855 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698963002856 dimerization interface [polypeptide binding]; other site 698963002857 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 698963002858 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 698963002859 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 698963002860 putative dimer interface [polypeptide binding]; other site 698963002861 N-terminal domain interface [polypeptide binding]; other site 698963002862 putative substrate binding pocket (H-site) [chemical binding]; other site 698963002863 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698963002864 Predicted membrane protein [Function unknown]; Region: COG2259 698963002865 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 698963002866 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698963002867 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 698963002868 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698963002869 PYR/PP interface [polypeptide binding]; other site 698963002870 dimer interface [polypeptide binding]; other site 698963002871 TPP binding site [chemical binding]; other site 698963002872 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698963002873 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 698963002874 TPP-binding site [chemical binding]; other site 698963002875 dimer interface [polypeptide binding]; other site 698963002876 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 698963002877 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 698963002878 putative valine binding site [chemical binding]; other site 698963002879 dimer interface [polypeptide binding]; other site 698963002880 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 698963002881 ketol-acid reductoisomerase; Provisional; Region: PRK05479 698963002882 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 698963002883 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 698963002884 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 698963002885 Uncharacterized conserved protein [Function unknown]; Region: COG1479 698963002886 Protein of unknown function DUF262; Region: DUF262; pfam03235 698963002887 Uncharacterized conserved protein [Function unknown]; Region: COG3472 698963002888 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 698963002889 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 698963002890 ligand binding site [chemical binding]; other site 698963002891 NAD binding site [chemical binding]; other site 698963002892 dimerization interface [polypeptide binding]; other site 698963002893 catalytic site [active] 698963002894 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 698963002895 putative L-serine binding site [chemical binding]; other site 698963002896 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 698963002897 tartrate dehydrogenase; Region: TTC; TIGR02089 698963002898 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698963002899 ligand binding site [chemical binding]; other site 698963002900 flexible hinge region; other site 698963002901 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698963002902 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698963002903 metal binding triad; other site 698963002904 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 698963002905 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 698963002906 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698963002907 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698963002908 catalytic site [active] 698963002909 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 698963002910 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 698963002911 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 698963002912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698963002913 isochorismate synthase DhbC; Validated; Region: PRK06923 698963002914 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698963002915 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 698963002916 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698963002917 active site 698963002918 HIGH motif; other site 698963002919 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698963002920 active site 698963002921 KMSKS motif; other site 698963002922 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 698963002923 MMPL family; Region: MMPL; pfam03176 698963002924 Ethanolamine utilisation protein, EutH; Region: EutH; cl01248 698963002925 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 698963002926 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 698963002927 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 698963002928 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 698963002929 PhnA protein; Region: PhnA; pfam03831 698963002930 biotin synthase; Region: bioB; TIGR00433 698963002931 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698963002932 FeS/SAM binding site; other site 698963002933 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698963002934 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698963002935 HD domain; Region: HD_4; pfam13328 698963002936 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698963002937 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698963002938 putative DNA binding site [nucleotide binding]; other site 698963002939 putative Zn2+ binding site [ion binding]; other site 698963002940 Bacterial transcriptional regulator; Region: IclR; pfam01614 698963002941 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 698963002942 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 698963002943 substrate binding site [chemical binding]; other site 698963002944 ligand binding site [chemical binding]; other site 698963002945 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 698963002946 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 698963002947 substrate binding site [chemical binding]; other site 698963002948 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698963002949 active site 698963002950 Ap6A binding site [chemical binding]; other site 698963002951 nudix motif; other site 698963002952 metal binding site [ion binding]; metal-binding site 698963002953 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698963002954 catalytic core [active] 698963002955 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 698963002956 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698963002957 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 698963002958 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 698963002959 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 698963002960 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698963002961 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698963002962 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698963002963 thiamine monophosphate kinase; Provisional; Region: PRK05731 698963002964 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 698963002965 ATP binding site [chemical binding]; other site 698963002966 dimerization interface [polypeptide binding]; other site 698963002967 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 698963002968 ligand binding site [chemical binding]; other site 698963002969 active site 698963002970 UGI interface [polypeptide binding]; other site 698963002971 catalytic site [active] 698963002972 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 698963002973 DAK2 domain; Region: Dak2; pfam02734 698963002974 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 698963002975 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 698963002976 generic binding surface II; other site 698963002977 ssDNA binding site; other site 698963002978 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698963002979 ATP binding site [chemical binding]; other site 698963002980 putative Mg++ binding site [ion binding]; other site 698963002981 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698963002982 nucleotide binding region [chemical binding]; other site 698963002983 ATP-binding site [chemical binding]; other site 698963002984 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 698963002985 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698963002986 carboxyltransferase (CT) interaction site; other site 698963002987 biotinylation site [posttranslational modification]; other site 698963002988 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 698963002989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698963002990 S-adenosylmethionine binding site [chemical binding]; other site 698963002991 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 698963002992 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 698963002993 active site 698963002994 (T/H)XGH motif; other site 698963002995 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698963002996 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698963002997 Walker A/P-loop; other site 698963002998 ATP binding site [chemical binding]; other site 698963002999 Q-loop/lid; other site 698963003000 ABC transporter signature motif; other site 698963003001 Walker B; other site 698963003002 D-loop; other site 698963003003 H-loop/switch region; other site 698963003004 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698963003005 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698963003006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698963003007 dimer interface [polypeptide binding]; other site 698963003008 conserved gate region; other site 698963003009 putative PBP binding loops; other site 698963003010 ABC-ATPase subunit interface; other site 698963003011 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698963003012 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698963003013 substrate binding pocket [chemical binding]; other site 698963003014 membrane-bound complex binding site; other site 698963003015 hinge residues; other site 698963003016 Domain of unknown function (DUF368); Region: DUF368; pfam04018 698963003017 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698963003018 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 698963003019 active site 698963003020 catalytic residues [active] 698963003021 DNA binding site [nucleotide binding] 698963003022 Int/Topo IB signature motif; other site 698963003023 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698963003024 sequence-specific DNA binding site [nucleotide binding]; other site 698963003025 salt bridge; other site 698963003026 Helix-turn-helix domain; Region: HTH_17; pfam12728 698963003027 DNA-binding interface [nucleotide binding]; DNA binding site 698963003028 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 698963003029 Phage terminase large subunit; Region: Terminase_3; cl12054 698963003030 Terminase-like family; Region: Terminase_6; pfam03237 698963003031 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 698963003032 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 698963003033 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 698963003034 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 698963003035 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 698963003036 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 698963003037 Protease specific for SMALL UBIQUITIN-RELATED MODIFIER (SUMO); Provisional; Region: PLN03189 698963003038 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 698963003039 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698963003040 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698963003041 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698963003042 catalytic residue [active] 698963003043 Protein of unknown function (DUF2744); Region: DUF2744; pfam10910 698963003044 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 698963003045 Phage tail repeat like; Region: PTR; pfam12789 698963003046 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 698963003047 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 698963003048 active site 698963003049 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 698963003050 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 698963003051 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698963003052 MULE transposase domain; Region: MULE; pfam10551 698963003053 Thymidylate synthase complementing protein; Region: Thy1; cl03630 698963003054 MULE transposase domain; Region: MULE; pfam10551 698963003055 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 698963003056 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 698963003057 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 698963003058 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 698963003059 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 698963003060 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698963003061 trimer interface [polypeptide binding]; other site 698963003062 active site 698963003063 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698963003064 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698963003065 dimer interface [polypeptide binding]; other site 698963003066 ssDNA binding site [nucleotide binding]; other site 698963003067 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698963003068 RecT family; Region: RecT; pfam03837 698963003069 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 698963003070 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 698963003071 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 698963003072 DNA polymerase I; Provisional; Region: PRK05755 698963003073 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 698963003074 active site 698963003075 metal binding site 1 [ion binding]; metal-binding site 698963003076 putative 5' ssDNA interaction site; other site 698963003077 metal binding site 3; metal-binding site 698963003078 metal binding site 2 [ion binding]; metal-binding site 698963003079 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 698963003080 putative DNA binding site [nucleotide binding]; other site 698963003081 putative metal binding site [ion binding]; other site 698963003082 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 698963003083 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 698963003084 active site 698963003085 DNA binding site [nucleotide binding] 698963003086 catalytic site [active] 698963003087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698963003088 S-adenosylmethionine binding site [chemical binding]; other site 698963003089 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 698963003090 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 698963003091 RNA binding site [nucleotide binding]; other site 698963003092 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 698963003093 RNA binding site [nucleotide binding]; other site 698963003094 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698963003095 RNA binding site [nucleotide binding]; other site 698963003096 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 698963003097 RNA binding site [nucleotide binding]; other site 698963003098 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 698963003099 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 698963003100 transcriptional antiterminator BglG; Provisional; Region: PRK09772 698963003101 CAT RNA binding domain; Region: CAT_RBD; smart01061 698963003102 PRD domain; Region: PRD; pfam00874 698963003103 PRD domain; Region: PRD; pfam00874 698963003104 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 698963003105 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698963003106 active site turn [active] 698963003107 phosphorylation site [posttranslational modification] 698963003108 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698963003109 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 698963003110 HPr interaction site; other site 698963003111 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698963003112 active site 698963003113 phosphorylation site [posttranslational modification] 698963003114 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 698963003115 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 698963003116 CoA-binding site [chemical binding]; other site 698963003117 ATP-binding [chemical binding]; other site 698963003118 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 698963003119 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698963003120 FeS/SAM binding site; other site 698963003121 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 698963003122 excinuclease ABC subunit B; Provisional; Region: PRK05298 698963003123 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698963003124 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698963003125 nucleotide binding region [chemical binding]; other site 698963003126 ATP-binding site [chemical binding]; other site 698963003127 Ultra-violet resistance protein B; Region: UvrB; pfam12344 698963003128 UvrB/uvrC motif; Region: UVR; pfam02151 698963003129 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698963003130 Ligand Binding Site [chemical binding]; other site 698963003131 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 698963003132 Part of AAA domain; Region: AAA_19; pfam13245 698963003133 PhoH-like protein; Region: PhoH; cl17668 698963003134 Family description; Region: UvrD_C_2; pfam13538 698963003135 Predicted membrane protein [Function unknown]; Region: COG2259 698963003136 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698963003137 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 698963003138 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698963003139 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698963003140 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 698963003141 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 698963003142 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 698963003143 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 698963003144 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 698963003145 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 698963003146 23S rRNA binding site [nucleotide binding]; other site 698963003147 L21 binding site [polypeptide binding]; other site 698963003148 L13 binding site [polypeptide binding]; other site 698963003149 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698963003150 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 698963003151 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698963003152 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 698963003153 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 698963003154 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 698963003155 dimer interface [polypeptide binding]; other site 698963003156 motif 1; other site 698963003157 active site 698963003158 motif 2; other site 698963003159 motif 3; other site 698963003160 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 698963003161 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 698963003162 putative tRNA-binding site [nucleotide binding]; other site 698963003163 B3/4 domain; Region: B3_4; pfam03483 698963003164 tRNA synthetase B5 domain; Region: B5; smart00874 698963003165 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 698963003166 dimer interface [polypeptide binding]; other site 698963003167 motif 1; other site 698963003168 motif 3; other site 698963003169 motif 2; other site 698963003170 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 698963003171 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 698963003172 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698963003173 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 698963003174 heterotetramer interface [polypeptide binding]; other site 698963003175 active site pocket [active] 698963003176 cleavage site 698963003177 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 698963003178 feedback inhibition sensing region; other site 698963003179 homohexameric interface [polypeptide binding]; other site 698963003180 nucleotide binding site [chemical binding]; other site 698963003181 N-acetyl-L-glutamate binding site [chemical binding]; other site 698963003182 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 698963003183 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698963003184 inhibitor-cofactor binding pocket; inhibition site 698963003185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698963003186 catalytic residue [active] 698963003187 ornithine carbamoyltransferase; Provisional; Region: PRK00779 698963003188 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698963003189 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698963003190 arginine repressor; Provisional; Region: PRK03341 698963003191 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 698963003192 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 698963003193 argininosuccinate synthase; Provisional; Region: PRK13820 698963003194 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 698963003195 ANP binding site [chemical binding]; other site 698963003196 Substrate Binding Site II [chemical binding]; other site 698963003197 Substrate Binding Site I [chemical binding]; other site 698963003198 argininosuccinate lyase; Provisional; Region: PRK00855 698963003199 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 698963003200 active sites [active] 698963003201 tetramer interface [polypeptide binding]; other site 698963003202 Uncharacterized conserved protein [Function unknown]; Region: COG2835 698963003203 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 698963003204 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 698963003205 active site 698963003206 HIGH motif; other site 698963003207 dimer interface [polypeptide binding]; other site 698963003208 KMSKS motif; other site 698963003209 S4 RNA-binding domain; Region: S4; smart00363 698963003210 transcription termination factor Rho; Provisional; Region: PRK12678 698963003211 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698963003212 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698963003213 active site 698963003214 motif I; other site 698963003215 motif II; other site 698963003216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698963003217 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 698963003218 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698963003219 RNA binding surface [nucleotide binding]; other site 698963003220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698963003221 S-adenosylmethionine binding site [chemical binding]; other site 698963003222 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 698963003223 ATP-NAD kinase; Region: NAD_kinase; pfam01513 698963003224 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 698963003225 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698963003226 Walker A/P-loop; other site 698963003227 ATP binding site [chemical binding]; other site 698963003228 Q-loop/lid; other site 698963003229 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698963003230 ABC transporter signature motif; other site 698963003231 Walker B; other site 698963003232 D-loop; other site 698963003233 H-loop/switch region; other site 698963003234 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 698963003235 Thiamine pyrophosphokinase; Region: TPK; cl08415 698963003236 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 698963003237 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 698963003238 dimer interface [polypeptide binding]; other site 698963003239 ADP-ribose binding site [chemical binding]; other site 698963003240 active site 698963003241 nudix motif; other site 698963003242 metal binding site [ion binding]; metal-binding site 698963003243 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 698963003244 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 698963003245 active site 698963003246 Int/Topo IB signature motif; other site 698963003247 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698963003248 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698963003249 P-loop; other site 698963003250 Magnesium ion binding site [ion binding]; other site 698963003251 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698963003252 Magnesium ion binding site [ion binding]; other site 698963003253 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 698963003254 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698963003255 potential frameshift: common BLAST hit: gi|38233780|ref|NP_939547.1| peptide transport protein 698963003256 POT family; Region: PTR2; cl17359 698963003257 POT family; Region: PTR2; cl17359 698963003258 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 698963003259 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698963003260 inhibitor-cofactor binding pocket; inhibition site 698963003261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698963003262 catalytic residue [active] 698963003263 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698963003264 AAA domain; Region: AAA_26; pfam13500 698963003265 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 698963003266 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 698963003267 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698963003268 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698963003269 RNA binding surface [nucleotide binding]; other site 698963003270 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 698963003271 active site 698963003272 cytidylate kinase; Provisional; Region: cmk; PRK00023 698963003273 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 698963003274 CMP-binding site; other site 698963003275 The sites determining sugar specificity; other site 698963003276 GTP-binding protein Der; Reviewed; Region: PRK03003 698963003277 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 698963003278 G1 box; other site 698963003279 GTP/Mg2+ binding site [chemical binding]; other site 698963003280 Switch I region; other site 698963003281 G2 box; other site 698963003282 Switch II region; other site 698963003283 G3 box; other site 698963003284 G4 box; other site 698963003285 G5 box; other site 698963003286 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 698963003287 G1 box; other site 698963003288 GTP/Mg2+ binding site [chemical binding]; other site 698963003289 Switch I region; other site 698963003290 G2 box; other site 698963003291 G3 box; other site 698963003292 Switch II region; other site 698963003293 G4 box; other site 698963003294 G5 box; other site 698963003295 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698963003296 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 698963003297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698963003298 S-adenosylmethionine binding site [chemical binding]; other site 698963003299 Putative esterase; Region: Esterase; pfam00756 698963003300 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698963003301 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 698963003302 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698963003303 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 698963003304 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698963003305 nucleotide binding region [chemical binding]; other site 698963003306 ATP-binding site [chemical binding]; other site 698963003307 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698963003308 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698963003309 phosphopeptide binding site; other site 698963003310 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 698963003311 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698963003312 DNA binding residues [nucleotide binding] 698963003313 Bifunctional nuclease; Region: DNase-RNase; pfam02577 698963003314 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 698963003315 DNA binding residues [nucleotide binding] 698963003316 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698963003317 putative dimer interface [polypeptide binding]; other site 698963003318 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698963003319 metal ion-dependent adhesion site (MIDAS); other site 698963003320 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698963003321 Domain of unknown function DUF21; Region: DUF21; pfam01595 698963003322 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698963003323 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698963003324 Domain of unknown function DUF21; Region: DUF21; pfam01595 698963003325 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698963003326 Transporter associated domain; Region: CorC_HlyC; smart01091 698963003327 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 698963003328 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698963003329 ATP binding site [chemical binding]; other site 698963003330 Mg++ binding site [ion binding]; other site 698963003331 motif III; other site 698963003332 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698963003333 nucleotide binding region [chemical binding]; other site 698963003334 ATP-binding site [chemical binding]; other site 698963003335 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698963003336 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 698963003337 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 698963003338 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 698963003339 CoenzymeA binding site [chemical binding]; other site 698963003340 subunit interaction site [polypeptide binding]; other site 698963003341 PHB binding site; other site 698963003342 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 698963003343 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 698963003344 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 698963003345 oligomer interface [polypeptide binding]; other site 698963003346 metal binding site [ion binding]; metal-binding site 698963003347 metal binding site [ion binding]; metal-binding site 698963003348 putative Cl binding site [ion binding]; other site 698963003349 basic sphincter; other site 698963003350 hydrophobic gate; other site 698963003351 periplasmic entrance; other site 698963003352 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698963003353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698963003354 S-adenosylmethionine binding site [chemical binding]; other site 698963003355 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698963003356 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698963003357 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698963003358 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 698963003359 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698963003360 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 698963003361 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698963003362 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 698963003363 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698963003364 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698963003365 FAD binding domain; Region: FAD_binding_4; pfam01565 698963003366 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698963003367 Sodium Bile acid symporter family; Region: SBF; pfam01758 698963003368 YceI-like domain; Region: YceI; pfam04264 698963003369 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 698963003370 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 698963003371 Ligand binding site; other site 698963003372 Putative Catalytic site; other site 698963003373 DXD motif; other site 698963003374 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 698963003375 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 698963003376 putative active site [active] 698963003377 catalytic triad [active] 698963003378 putative dimer interface [polypeptide binding]; other site 698963003379 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 698963003380 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 698963003381 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698963003382 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698963003383 precorrin-3B synthase; Region: CobG; TIGR02435 698963003384 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698963003385 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698963003386 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 698963003387 Precorrin-8X methylmutase; Region: CbiC; pfam02570 698963003388 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 698963003389 active site 698963003390 SAM binding site [chemical binding]; other site 698963003391 homodimer interface [polypeptide binding]; other site 698963003392 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 698963003393 active site 698963003394 SAM binding site [chemical binding]; other site 698963003395 homodimer interface [polypeptide binding]; other site 698963003396 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 698963003397 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 698963003398 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 698963003399 active site 698963003400 SAM binding site [chemical binding]; other site 698963003401 homodimer interface [polypeptide binding]; other site 698963003402 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 698963003403 active site 698963003404 putative homodimer interface [polypeptide binding]; other site 698963003405 SAM binding site [chemical binding]; other site 698963003406 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 698963003407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698963003408 S-adenosylmethionine binding site [chemical binding]; other site 698963003409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698963003410 short chain dehydrogenase; Provisional; Region: PRK08251 698963003411 NAD(P) binding site [chemical binding]; other site 698963003412 active site 698963003413 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698963003414 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698963003415 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698963003416 active site 698963003417 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698963003418 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698963003419 ATP binding site [chemical binding]; other site 698963003420 putative Mg++ binding site [ion binding]; other site 698963003421 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698963003422 nucleotide binding region [chemical binding]; other site 698963003423 ATP-binding site [chemical binding]; other site 698963003424 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 698963003425 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 698963003426 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 698963003427 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 698963003428 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 698963003429 Predicted transcriptional regulator [Transcription]; Region: COG2378 698963003430 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 698963003431 WYL domain; Region: WYL; pfam13280 698963003432 WYL domain; Region: WYL; pfam13280 698963003433 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 698963003434 Pup-like protein; Region: Pup; pfam05639 698963003435 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 698963003436 proteasome ATPase; Region: pup_AAA; TIGR03689 698963003437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698963003438 Walker A motif; other site 698963003439 ATP binding site [chemical binding]; other site 698963003440 Walker B motif; other site 698963003441 arginine finger; other site 698963003442 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 698963003443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698963003444 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 698963003445 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 698963003446 active site 698963003447 metal binding site [ion binding]; metal-binding site 698963003448 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 698963003449 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 698963003450 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 698963003451 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 698963003452 Potassium binding sites [ion binding]; other site 698963003453 Cesium cation binding sites [ion binding]; other site 698963003454 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 698963003455 Aspartase; Region: Aspartase; cd01357 698963003456 active sites [active] 698963003457 tetramer interface [polypeptide binding]; other site 698963003458 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698963003459 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 698963003460 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 698963003461 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 698963003462 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 698963003463 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 698963003464 homodimer interface [polypeptide binding]; other site 698963003465 putative metal binding site [ion binding]; other site 698963003466 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 698963003467 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698963003468 motif II; other site 698963003469 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 698963003470 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 698963003471 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 698963003472 substrate binding pocket [chemical binding]; other site 698963003473 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 698963003474 B12 binding site [chemical binding]; other site 698963003475 cobalt ligand [ion binding]; other site 698963003476 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 698963003477 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 698963003478 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698963003479 active site 698963003480 HIGH motif; other site 698963003481 nucleotide binding site [chemical binding]; other site 698963003482 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698963003483 active site 698963003484 KMSKS motif; other site 698963003485 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698963003486 tRNA binding surface [nucleotide binding]; other site 698963003487 anticodon binding site; other site 698963003488 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 698963003489 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 698963003490 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 698963003491 quinone interaction residues [chemical binding]; other site 698963003492 active site 698963003493 catalytic residues [active] 698963003494 FMN binding site [chemical binding]; other site 698963003495 substrate binding site [chemical binding]; other site 698963003496 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 698963003497 substrate binding site [chemical binding]; other site 698963003498 potential frameshift: common BLAST hit: gi|38233440|ref|NP_939207.1| transposase 698963003499 Integrase core domain; Region: rve_2; pfam13333 698963003500 potential frameshift: common BLAST hit: gi|38233854|ref|NP_939621.1| transposase 698963003501 Integrase core domain; Region: rve; pfam00665 698963003502 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698963003503 HTH-like domain; Region: HTH_21; pfam13276 698963003504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698963003505 potential frameshift: common BLAST hit: gi|312139676|ref|YP_004007012.1| short chain dehydrogenase 698963003506 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698963003507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698963003508 active site 698963003509 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698963003510 active site residue [active] 698963003511 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698963003512 active site residue [active] 698963003513 membrane ATPase/protein kinase; Provisional; Region: PRK09435 698963003514 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 698963003515 Walker A; other site 698963003516 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 698963003517 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 698963003518 active site 698963003519 substrate binding site [chemical binding]; other site 698963003520 coenzyme B12 binding site [chemical binding]; other site 698963003521 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 698963003522 B12 binding site [chemical binding]; other site 698963003523 cobalt ligand [ion binding]; other site 698963003524 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 698963003525 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 698963003526 heterodimer interface [polypeptide binding]; other site 698963003527 substrate interaction site [chemical binding]; other site 698963003528 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 698963003529 Uncharacterized conserved protein [Function unknown]; Region: COG0398 698963003530 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 698963003531 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698963003532 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 698963003533 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 698963003534 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 698963003535 ferrochelatase; Reviewed; Region: hemH; PRK00035 698963003536 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 698963003537 C-terminal domain interface [polypeptide binding]; other site 698963003538 active site 698963003539 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 698963003540 active site 698963003541 N-terminal domain interface [polypeptide binding]; other site 698963003542 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698963003543 NlpC/P60 family; Region: NLPC_P60; pfam00877 698963003544 aconitate hydratase; Validated; Region: PRK09277 698963003545 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698963003546 substrate binding site [chemical binding]; other site 698963003547 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698963003548 ligand binding site [chemical binding]; other site 698963003549 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 698963003550 substrate binding site [chemical binding]; other site 698963003551 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698963003552 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698963003553 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 698963003554 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 698963003555 catalytic triad [active] 698963003556 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 698963003557 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 698963003558 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698963003559 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698963003560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963003561 Walker A/P-loop; other site 698963003562 ATP binding site [chemical binding]; other site 698963003563 Q-loop/lid; other site 698963003564 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698963003565 ABC transporter signature motif; other site 698963003566 Walker B; other site 698963003567 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698963003568 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 698963003569 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 698963003570 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 698963003571 trimerization site [polypeptide binding]; other site 698963003572 active site 698963003573 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698963003574 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 698963003575 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698963003576 catalytic residue [active] 698963003577 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 698963003578 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 698963003579 Walker A/P-loop; other site 698963003580 ATP binding site [chemical binding]; other site 698963003581 Q-loop/lid; other site 698963003582 ABC transporter signature motif; other site 698963003583 Walker B; other site 698963003584 D-loop; other site 698963003585 H-loop/switch region; other site 698963003586 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 698963003587 FeS assembly protein SufD; Region: sufD; TIGR01981 698963003588 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 698963003589 FeS assembly protein SufB; Region: sufB; TIGR01980 698963003590 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698963003591 Predicted transcriptional regulator [Transcription]; Region: COG2345 698963003592 putative DNA binding site [nucleotide binding]; other site 698963003593 putative Zn2+ binding site [ion binding]; other site 698963003594 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698963003595 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698963003596 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698963003597 Walker A/P-loop; other site 698963003598 ATP binding site [chemical binding]; other site 698963003599 Q-loop/lid; other site 698963003600 ABC transporter signature motif; other site 698963003601 Walker B; other site 698963003602 D-loop; other site 698963003603 H-loop/switch region; other site 698963003604 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698963003605 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698963003606 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 698963003607 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 698963003608 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 698963003609 UbiA prenyltransferase family; Region: UbiA; pfam01040 698963003610 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 698963003611 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 698963003612 TPP-binding site [chemical binding]; other site 698963003613 dimer interface [polypeptide binding]; other site 698963003614 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698963003615 PYR/PP interface [polypeptide binding]; other site 698963003616 dimer interface [polypeptide binding]; other site 698963003617 TPP binding site [chemical binding]; other site 698963003618 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698963003619 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 698963003620 putative active site [active] 698963003621 transaldolase; Provisional; Region: PRK03903 698963003622 catalytic residue [active] 698963003623 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 698963003624 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 698963003625 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 698963003626 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 698963003627 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 698963003628 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698963003629 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 698963003630 putative active site [active] 698963003631 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 698963003632 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 698963003633 triosephosphate isomerase; Provisional; Region: PRK14567 698963003634 substrate binding site [chemical binding]; other site 698963003635 dimer interface [polypeptide binding]; other site 698963003636 catalytic triad [active] 698963003637 Phosphoglycerate kinase; Region: PGK; pfam00162 698963003638 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 698963003639 substrate binding site [chemical binding]; other site 698963003640 hinge regions; other site 698963003641 ADP binding site [chemical binding]; other site 698963003642 catalytic site [active] 698963003643 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 698963003644 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 698963003645 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698963003646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 698963003647 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 698963003648 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 698963003649 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 698963003650 phosphate binding site [ion binding]; other site 698963003651 putative substrate binding pocket [chemical binding]; other site 698963003652 dimer interface [polypeptide binding]; other site 698963003653 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 698963003654 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 698963003655 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 698963003656 GIY-YIG motif/motif A; other site 698963003657 active site 698963003658 catalytic site [active] 698963003659 putative DNA binding site [nucleotide binding]; other site 698963003660 metal binding site [ion binding]; metal-binding site 698963003661 UvrB/uvrC motif; Region: UVR; pfam02151 698963003662 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 698963003663 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698963003664 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 698963003665 homopentamer interface [polypeptide binding]; other site 698963003666 active site 698963003667 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 698963003668 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 698963003669 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 698963003670 dimerization interface [polypeptide binding]; other site 698963003671 active site 698963003672 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 698963003673 Lumazine binding domain; Region: Lum_binding; pfam00677 698963003674 Lumazine binding domain; Region: Lum_binding; pfam00677 698963003675 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 698963003676 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 698963003677 catalytic motif [active] 698963003678 Zn binding site [ion binding]; other site 698963003679 RibD C-terminal domain; Region: RibD_C; pfam01872 698963003680 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 698963003681 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 698963003682 substrate binding site [chemical binding]; other site 698963003683 hexamer interface [polypeptide binding]; other site 698963003684 metal binding site [ion binding]; metal-binding site 698963003685 16S rRNA methyltransferase B; Provisional; Region: PRK14902 698963003686 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 698963003687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698963003688 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 698963003689 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 698963003690 putative active site [active] 698963003691 substrate binding site [chemical binding]; other site 698963003692 putative cosubstrate binding site; other site 698963003693 catalytic site [active] 698963003694 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 698963003695 substrate binding site [chemical binding]; other site 698963003696 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698963003697 active site 698963003698 catalytic residues [active] 698963003699 metal binding site [ion binding]; metal-binding site 698963003700 primosome assembly protein PriA; Provisional; Region: PRK14873 698963003701 S-adenosylmethionine synthetase; Validated; Region: PRK05250 698963003702 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 698963003703 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 698963003704 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 698963003705 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 698963003706 Flavoprotein; Region: Flavoprotein; pfam02441 698963003707 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 698963003708 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 698963003709 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 698963003710 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 698963003711 catalytic site [active] 698963003712 G-X2-G-X-G-K; other site 698963003713 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 698963003714 active site 698963003715 dimer interface [polypeptide binding]; other site 698963003716 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 698963003717 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698963003718 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698963003719 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 698963003720 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698963003721 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698963003722 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 698963003723 IMP binding site; other site 698963003724 dimer interface [polypeptide binding]; other site 698963003725 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 698963003726 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 698963003727 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 698963003728 catalytic site [active] 698963003729 subunit interface [polypeptide binding]; other site 698963003730 dihydroorotase; Validated; Region: pyrC; PRK09357 698963003731 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698963003732 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 698963003733 active site 698963003734 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 698963003735 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698963003736 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698963003737 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 698963003738 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698963003739 active site 698963003740 hydrophobic ligand binding site; other site 698963003741 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698963003742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698963003743 TIGR01777 family protein; Region: yfcH 698963003744 NAD(P) binding site [chemical binding]; other site 698963003745 active site 698963003746 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 698963003747 elongation factor P; Validated; Region: PRK00529 698963003748 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 698963003749 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 698963003750 RNA binding site [nucleotide binding]; other site 698963003751 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 698963003752 RNA binding site [nucleotide binding]; other site 698963003753 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698963003754 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698963003755 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698963003756 active site 698963003757 Dehydroquinase class II; Region: DHquinase_II; pfam01220 698963003758 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 698963003759 trimer interface [polypeptide binding]; other site 698963003760 active site 698963003761 dimer interface [polypeptide binding]; other site 698963003762 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 698963003763 active site 698963003764 dimer interface [polypeptide binding]; other site 698963003765 metal binding site [ion binding]; metal-binding site 698963003766 shikimate kinase; Reviewed; Region: aroK; PRK00131 698963003767 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 698963003768 ADP binding site [chemical binding]; other site 698963003769 magnesium binding site [ion binding]; other site 698963003770 putative shikimate binding site; other site 698963003771 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 698963003772 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 698963003773 Tetramer interface [polypeptide binding]; other site 698963003774 active site 698963003775 FMN-binding site [chemical binding]; other site 698963003776 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 698963003777 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698963003778 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698963003779 shikimate binding site; other site 698963003780 NAD(P) binding site [chemical binding]; other site 698963003781 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 698963003782 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 698963003783 dimerization interface [polypeptide binding]; other site 698963003784 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 698963003785 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 698963003786 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 698963003787 motif 1; other site 698963003788 active site 698963003789 motif 2; other site 698963003790 motif 3; other site 698963003791 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698963003792 DHHA1 domain; Region: DHHA1; pfam02272 698963003793 recombination factor protein RarA; Reviewed; Region: PRK13342 698963003794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698963003795 Walker A motif; other site 698963003796 ATP binding site [chemical binding]; other site 698963003797 Walker B motif; other site 698963003798 arginine finger; other site 698963003799 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 698963003800 Phosphotransferase enzyme family; Region: APH; pfam01636 698963003801 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698963003802 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 698963003803 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 698963003804 dimer interface [polypeptide binding]; other site 698963003805 anticodon binding site; other site 698963003806 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 698963003807 homodimer interface [polypeptide binding]; other site 698963003808 motif 1; other site 698963003809 active site 698963003810 motif 2; other site 698963003811 GAD domain; Region: GAD; pfam02938 698963003812 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698963003813 active site 698963003814 motif 3; other site 698963003815 Predicted metalloprotease [General function prediction only]; Region: COG2321 698963003816 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 698963003817 potential frameshift: common BLAST hit: gi|62390520|ref|YP_225922.1| SNF2 family DNA/RNA helicase 698963003818 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698963003819 ATP binding site [chemical binding]; other site 698963003820 putative Mg++ binding site [ion binding]; other site 698963003821 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698963003822 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 698963003823 nucleotide binding region [chemical binding]; other site 698963003824 ATP-binding site [chemical binding]; other site 698963003825 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 698963003826 Predicted membrane protein [Function unknown]; Region: COG1511 698963003827 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698963003828 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698963003829 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698963003830 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698963003831 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698963003832 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963003833 Q-loop/lid; other site 698963003834 ABC transporter signature motif; other site 698963003835 Walker B; other site 698963003836 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698963003837 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698963003838 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698963003839 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698963003840 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698963003841 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 698963003842 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 698963003843 dimer interface [polypeptide binding]; other site 698963003844 motif 1; other site 698963003845 active site 698963003846 motif 2; other site 698963003847 motif 3; other site 698963003848 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 698963003849 anticodon binding site; other site 698963003850 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698963003851 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 698963003852 dimer interface [polypeptide binding]; other site 698963003853 catalytic triad [active] 698963003854 peroxidatic and resolving cysteines [active] 698963003855 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698963003856 active site 698963003857 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698963003858 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698963003859 Zn2+ binding site [ion binding]; other site 698963003860 Mg2+ binding site [ion binding]; other site 698963003861 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698963003862 synthetase active site [active] 698963003863 NTP binding site [chemical binding]; other site 698963003864 metal binding site [ion binding]; metal-binding site 698963003865 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 698963003866 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 698963003867 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698963003868 active site 698963003869 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 698963003870 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698963003871 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 698963003872 Protein export membrane protein; Region: SecD_SecF; cl14618 698963003873 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 698963003874 Protein export membrane protein; Region: SecD_SecF; cl14618 698963003875 Preprotein translocase subunit; Region: YajC; pfam02699 698963003876 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 698963003877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698963003878 Walker A motif; other site 698963003879 ATP binding site [chemical binding]; other site 698963003880 Walker B motif; other site 698963003881 arginine finger; other site 698963003882 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 698963003883 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 698963003884 RuvA N terminal domain; Region: RuvA_N; pfam01330 698963003885 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 698963003886 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 698963003887 active site 698963003888 putative DNA-binding cleft [nucleotide binding]; other site 698963003889 dimer interface [polypeptide binding]; other site 698963003890 hypothetical protein; Validated; Region: PRK00110 698963003891 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 698963003892 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 698963003893 active site 698963003894 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 698963003895 catalytic triad [active] 698963003896 dimer interface [polypeptide binding]; other site 698963003897 HTH-like domain; Region: HTH_21; pfam13276 698963003898 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698963003899 Helix-turn-helix domain; Region: HTH_38; pfam13936 698963003900 Integrase core domain; Region: rve; pfam00665 698963003901 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 698963003902 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 698963003903 Nitronate monooxygenase; Region: NMO; pfam03060 698963003904 FMN binding site [chemical binding]; other site 698963003905 substrate binding site [chemical binding]; other site 698963003906 putative catalytic residue [active] 698963003907 Replicase family; Region: Replicase; pfam03090 698963003908 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 698963003909 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698963003910 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698963003911 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698963003912 catalytic residues [active] 698963003913 catalytic nucleophile [active] 698963003914 Presynaptic Site I dimer interface [polypeptide binding]; other site 698963003915 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698963003916 Synaptic Flat tetramer interface [polypeptide binding]; other site 698963003917 Synaptic Site I dimer interface [polypeptide binding]; other site 698963003918 DNA binding site [nucleotide binding] 698963003919 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698963003920 MULE transposase domain; Region: MULE; pfam10551 698963003921 potential frameshift: common BLAST hit: gi|68536874|ref|YP_251579.1| transposase IS3525 698963003922 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698963003923 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698963003924 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698963003925 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 698963003926 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 698963003927 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698963003928 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698963003929 catalytic residue [active] 698963003930 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698963003931 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698963003932 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 698963003933 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 698963003934 putative acyl-acceptor binding pocket; other site 698963003935 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698963003936 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 698963003937 nucleotide binding site/active site [active] 698963003938 HIT family signature motif; other site 698963003939 catalytic residue [active] 698963003940 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 698963003941 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698963003942 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 698963003943 active site 698963003944 dimer interface [polypeptide binding]; other site 698963003945 motif 1; other site 698963003946 motif 2; other site 698963003947 motif 3; other site 698963003948 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 698963003949 anticodon binding site; other site 698963003950 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 698963003951 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 698963003952 Protein of unknown function (DUF461); Region: DUF461; pfam04314 698963003953 CopC domain; Region: CopC; cl01012 698963003954 hypothetical protein; Provisional; Region: PRK14059 698963003955 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 698963003956 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 698963003957 SelR domain; Region: SelR; pfam01641 698963003958 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 698963003959 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 698963003960 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 698963003961 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 698963003962 catalytic site [active] 698963003963 putative active site [active] 698963003964 putative substrate binding site [chemical binding]; other site 698963003965 HRDC domain; Region: HRDC; pfam00570 698963003966 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 698963003967 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 698963003968 TPP-binding site; other site 698963003969 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698963003970 PYR/PP interface [polypeptide binding]; other site 698963003971 dimer interface [polypeptide binding]; other site 698963003972 TPP binding site [chemical binding]; other site 698963003973 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698963003974 TRAM domain; Region: TRAM; cl01282 698963003975 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 698963003976 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 698963003977 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698963003978 trimer interface [polypeptide binding]; other site 698963003979 active site 698963003980 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 698963003981 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 698963003982 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698963003983 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 698963003984 active site 698963003985 dimerization interface [polypeptide binding]; other site 698963003986 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698963003987 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698963003988 nucleotide binding site [chemical binding]; other site 698963003989 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698963003990 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698963003991 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698963003992 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698963003993 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698963003994 DNA binding residues [nucleotide binding] 698963003995 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698963003996 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698963003997 ATP binding site [chemical binding]; other site 698963003998 putative Mg++ binding site [ion binding]; other site 698963003999 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 698963004000 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 698963004001 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 698963004002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698963004003 S-adenosylmethionine binding site [chemical binding]; other site 698963004004 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 698963004005 putative active site [active] 698963004006 dimerization interface [polypeptide binding]; other site 698963004007 putative tRNAtyr binding site [nucleotide binding]; other site 698963004008 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698963004009 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698963004010 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698963004011 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698963004012 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698963004013 DNA binding residues [nucleotide binding] 698963004014 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698963004015 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698963004016 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698963004017 FeoA domain; Region: FeoA; cl00838 698963004018 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 698963004019 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 698963004020 NAD binding site [chemical binding]; other site 698963004021 homodimer interface [polypeptide binding]; other site 698963004022 active site 698963004023 substrate binding site [chemical binding]; other site 698963004024 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 698963004025 PAC2 family; Region: PAC2; pfam09754 698963004026 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698963004027 ATP binding site [chemical binding]; other site 698963004028 putative Mg++ binding site [ion binding]; other site 698963004029 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698963004030 nucleotide binding region [chemical binding]; other site 698963004031 ATP-binding site [chemical binding]; other site 698963004032 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 698963004033 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 698963004034 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 698963004035 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698963004036 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 698963004037 dimer interface [polypeptide binding]; other site 698963004038 decamer (pentamer of dimers) interface [polypeptide binding]; other site 698963004039 catalytic triad [active] 698963004040 peroxidatic and resolving cysteines [active] 698963004041 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698963004042 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 698963004043 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 698963004044 dimerization interface [polypeptide binding]; other site 698963004045 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 698963004046 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698963004047 ATP binding site [chemical binding]; other site 698963004048 putative Mg++ binding site [ion binding]; other site 698963004049 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698963004050 nucleotide binding region [chemical binding]; other site 698963004051 ATP-binding site [chemical binding]; other site 698963004052 Helicase associated domain (HA2); Region: HA2; pfam04408 698963004053 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 698963004054 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 698963004055 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 698963004056 ATP cone domain; Region: ATP-cone; pfam03477 698963004057 LexA repressor; Validated; Region: PRK00215 698963004058 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 698963004059 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698963004060 Catalytic site [active] 698963004061 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698963004062 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 698963004063 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698963004064 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 698963004065 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 698963004066 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 698963004067 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 698963004068 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698963004069 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698963004070 DNA-binding site [nucleotide binding]; DNA binding site 698963004071 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698963004072 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 698963004073 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 698963004074 putative substrate binding site [chemical binding]; other site 698963004075 putative ATP binding site [chemical binding]; other site 698963004076 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698963004077 dimerization domain swap beta strand [polypeptide binding]; other site 698963004078 regulatory protein interface [polypeptide binding]; other site 698963004079 active site 698963004080 regulatory phosphorylation site [posttranslational modification]; other site 698963004081 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 698963004082 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 698963004083 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698963004084 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 698963004085 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 698963004086 GTPases [General function prediction only]; Region: HflX; COG2262 698963004087 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 698963004088 HflX GTPase family; Region: HflX; cd01878 698963004089 G1 box; other site 698963004090 GTP/Mg2+ binding site [chemical binding]; other site 698963004091 Switch I region; other site 698963004092 G2 box; other site 698963004093 G3 box; other site 698963004094 Switch II region; other site 698963004095 G4 box; other site 698963004096 G5 box; other site 698963004097 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 698963004098 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698963004099 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698963004100 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 698963004101 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 698963004102 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698963004103 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698963004104 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698963004105 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698963004106 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 698963004107 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 698963004108 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698963004109 FeS/SAM binding site; other site 698963004110 recombination regulator RecX; Reviewed; Region: recX; PRK00117 698963004111 recombinase A; Provisional; Region: recA; PRK09354 698963004112 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 698963004113 hexamer interface [polypeptide binding]; other site 698963004114 Walker A motif; other site 698963004115 ATP binding site [chemical binding]; other site 698963004116 Walker B motif; other site 698963004117 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 698963004118 BioY family; Region: BioY; pfam02632 698963004119 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698963004120 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698963004121 Walker A/P-loop; other site 698963004122 ATP binding site [chemical binding]; other site 698963004123 Q-loop/lid; other site 698963004124 ABC transporter signature motif; other site 698963004125 Walker B; other site 698963004126 D-loop; other site 698963004127 H-loop/switch region; other site 698963004128 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698963004129 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698963004130 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698963004131 sequence-specific DNA binding site [nucleotide binding]; other site 698963004132 salt bridge; other site 698963004133 Competence-damaged protein; Region: CinA; pfam02464 698963004134 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698963004135 YCII-related domain; Region: YCII; cl00999 698963004136 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 698963004137 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 698963004138 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698963004139 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 698963004140 TIGR03085 family protein; Region: TIGR03085 698963004141 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 698963004142 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698963004143 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 698963004144 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 698963004145 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698963004146 dimer interface [polypeptide binding]; other site 698963004147 active site 698963004148 catalytic residue [active] 698963004149 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 698963004150 dihydrodipicolinate reductase; Provisional; Region: PRK00048 698963004151 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 698963004152 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 698963004153 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 698963004154 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 698963004155 oligomer interface [polypeptide binding]; other site 698963004156 RNA binding site [nucleotide binding]; other site 698963004157 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 698963004158 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 698963004159 RNase E interface [polypeptide binding]; other site 698963004160 trimer interface [polypeptide binding]; other site 698963004161 active site 698963004162 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 698963004163 putative nucleic acid binding region [nucleotide binding]; other site 698963004164 G-X-X-G motif; other site 698963004165 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 698963004166 RNA binding site [nucleotide binding]; other site 698963004167 domain interface; other site 698963004168 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 698963004169 16S/18S rRNA binding site [nucleotide binding]; other site 698963004170 S13e-L30e interaction site [polypeptide binding]; other site 698963004171 25S rRNA binding site [nucleotide binding]; other site 698963004172 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 698963004173 active site 698963004174 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 698963004175 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 698963004176 active site 698963004177 Riboflavin kinase; Region: Flavokinase; smart00904 698963004178 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 698963004179 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 698963004180 RNA binding site [nucleotide binding]; other site 698963004181 active site 698963004182 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 698963004183 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 698963004184 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 698963004185 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698963004186 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698963004187 active site 698963004188 metal binding site [ion binding]; metal-binding site 698963004189 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698963004190 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 698963004191 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 698963004192 DHH family; Region: DHH; pfam01368 698963004193 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 698963004194 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698963004195 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698963004196 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 698963004197 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 698963004198 G1 box; other site 698963004199 putative GEF interaction site [polypeptide binding]; other site 698963004200 GTP/Mg2+ binding site [chemical binding]; other site 698963004201 Switch I region; other site 698963004202 G2 box; other site 698963004203 G3 box; other site 698963004204 Switch II region; other site 698963004205 G4 box; other site 698963004206 G5 box; other site 698963004207 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 698963004208 Translation-initiation factor 2; Region: IF-2; pfam11987 698963004209 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 698963004210 Protein of unknown function (DUF448); Region: DUF448; pfam04296 698963004211 putative RNA binding cleft [nucleotide binding]; other site 698963004212 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 698963004213 NusA N-terminal domain; Region: NusA_N; pfam08529 698963004214 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 698963004215 RNA binding site [nucleotide binding]; other site 698963004216 homodimer interface [polypeptide binding]; other site 698963004217 NusA-like KH domain; Region: KH_5; pfam13184 698963004218 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 698963004219 G-X-X-G motif; other site 698963004220 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 698963004221 Sm and related proteins; Region: Sm_like; cl00259 698963004222 prolyl-tRNA synthetase; Provisional; Region: PRK09194 698963004223 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 698963004224 dimer interface [polypeptide binding]; other site 698963004225 motif 1; other site 698963004226 active site 698963004227 motif 2; other site 698963004228 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 698963004229 putative deacylase active site [active] 698963004230 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698963004231 active site 698963004232 motif 3; other site 698963004233 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 698963004234 anticodon binding site; other site 698963004235 hypothetical protein; Validated; Region: PRK02101 698963004236 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 698963004237 active site 698963004238 SAM binding site [chemical binding]; other site 698963004239 homodimer interface [polypeptide binding]; other site 698963004240 Uncharacterized conserved protein [Function unknown]; Region: COG0397 698963004241 hypothetical protein; Validated; Region: PRK00029 698963004242 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698963004243 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 698963004244 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 698963004245 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 698963004246 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698963004247 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 698963004248 catalytic triad [active] 698963004249 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 698963004250 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 698963004251 Walker A motif; other site 698963004252 homodimer interface [polypeptide binding]; other site 698963004253 ATP binding site [chemical binding]; other site 698963004254 hydroxycobalamin binding site [chemical binding]; other site 698963004255 Walker B motif; other site 698963004256 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 698963004257 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 698963004258 metal ion-dependent adhesion site (MIDAS); other site 698963004259 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 698963004260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698963004261 Walker A motif; other site 698963004262 ATP binding site [chemical binding]; other site 698963004263 Walker B motif; other site 698963004264 arginine finger; other site 698963004265 malate:quinone oxidoreductase; Validated; Region: PRK05257 698963004266 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 698963004267 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698963004268 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698963004269 mycothione reductase; Region: mycothione_red; TIGR03452 698963004270 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698963004271 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698963004272 cobyric acid synthase; Provisional; Region: PRK00784 698963004273 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 698963004274 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698963004275 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698963004276 catalytic triad [active] 698963004277 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698963004278 active site 698963004279 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 698963004280 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698963004281 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 698963004282 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698963004283 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698963004284 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 698963004285 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698963004286 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 698963004287 protein binding site [polypeptide binding]; other site 698963004288 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 698963004289 putative substrate binding region [chemical binding]; other site 698963004290 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 698963004291 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 698963004292 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 698963004293 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 698963004294 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 698963004295 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 698963004296 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698963004297 FeS/SAM binding site; other site 698963004298 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 698963004299 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 698963004300 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 698963004301 ribosome recycling factor; Reviewed; Region: frr; PRK00083 698963004302 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 698963004303 hinge region; other site 698963004304 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 698963004305 putative nucleotide binding site [chemical binding]; other site 698963004306 uridine monophosphate binding site [chemical binding]; other site 698963004307 homohexameric interface [polypeptide binding]; other site 698963004308 elongation factor Ts; Provisional; Region: tsf; PRK09377 698963004309 UBA/TS-N domain; Region: UBA; pfam00627 698963004310 Elongation factor TS; Region: EF_TS; pfam00889 698963004311 Elongation factor TS; Region: EF_TS; pfam00889 698963004312 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 698963004313 rRNA interaction site [nucleotide binding]; other site 698963004314 S8 interaction site; other site 698963004315 putative laminin-1 binding site; other site 698963004316 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698963004317 Peptidase family M23; Region: Peptidase_M23; pfam01551 698963004318 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698963004319 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 698963004320 active site 698963004321 DNA binding site [nucleotide binding] 698963004322 Int/Topo IB signature motif; other site 698963004323 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 698963004324 DNA protecting protein DprA; Region: dprA; TIGR00732 698963004325 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 698963004326 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698963004327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698963004328 Walker A motif; other site 698963004329 ATP binding site [chemical binding]; other site 698963004330 Walker B motif; other site 698963004331 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 698963004332 hypothetical protein; Reviewed; Region: PRK12497 698963004333 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 698963004334 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 698963004335 RNA/DNA hybrid binding site [nucleotide binding]; other site 698963004336 active site 698963004337 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 698963004338 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698963004339 Catalytic site [active] 698963004340 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698963004341 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 698963004342 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 698963004343 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 698963004344 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 698963004345 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698963004346 RNA binding site [nucleotide binding]; other site 698963004347 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 698963004348 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 698963004349 RimM N-terminal domain; Region: RimM; pfam01782 698963004350 PRC-barrel domain; Region: PRC; pfam05239 698963004351 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 698963004352 signal recognition particle protein; Provisional; Region: PRK10867 698963004353 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 698963004354 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 698963004355 P loop; other site 698963004356 GTP binding site [chemical binding]; other site 698963004357 Signal peptide binding domain; Region: SRP_SPB; pfam02978 698963004358 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 698963004359 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698963004360 metal binding triad; other site 698963004361 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698963004362 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 698963004363 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 698963004364 Nitrogen regulatory protein P-II; Region: P-II; smart00938 698963004365 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 698963004366 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 698963004367 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 698963004368 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698963004369 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 698963004370 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698963004371 Walker A/P-loop; other site 698963004372 ATP binding site [chemical binding]; other site 698963004373 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 698963004374 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698963004375 ABC transporter signature motif; other site 698963004376 Walker B; other site 698963004377 D-loop; other site 698963004378 H-loop/switch region; other site 698963004379 Acylphosphatase; Region: Acylphosphatase; cl00551 698963004380 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698963004381 amino acid carrier protein; Region: agcS; TIGR00835 698963004382 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 698963004383 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 698963004384 DNA binding site [nucleotide binding] 698963004385 catalytic residue [active] 698963004386 H2TH interface [polypeptide binding]; other site 698963004387 putative catalytic residues [active] 698963004388 turnover-facilitating residue; other site 698963004389 intercalation triad [nucleotide binding]; other site 698963004390 8OG recognition residue [nucleotide binding]; other site 698963004391 putative reading head residues; other site 698963004392 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698963004393 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698963004394 ribonuclease III; Reviewed; Region: rnc; PRK00102 698963004395 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 698963004396 dimerization interface [polypeptide binding]; other site 698963004397 active site 698963004398 metal binding site [ion binding]; metal-binding site 698963004399 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 698963004400 dsRNA binding site [nucleotide binding]; other site 698963004401 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 698963004402 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698963004403 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 698963004404 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 698963004405 active site 698963004406 catalytic site [active] 698963004407 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 698963004408 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 698963004409 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 698963004410 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 698963004411 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 698963004412 RNA binding site [nucleotide binding]; other site 698963004413 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 698963004414 Integrase core domain; Region: rve; pfam00665 698963004415 Integrase core domain; Region: rve_3; pfam13683 698963004416 glutamate dehydrogenase; Provisional; Region: PRK09414 698963004417 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 698963004418 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 698963004419 NAD(P) binding site [chemical binding]; other site 698963004420 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 698963004421 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698963004422 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698963004423 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 698963004424 metal binding site [ion binding]; metal-binding site 698963004425 putative dimer interface [polypeptide binding]; other site 698963004426 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 698963004427 homodimer interface [polypeptide binding]; other site 698963004428 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 698963004429 active site pocket [active] 698963004430 pyruvate kinase; Provisional; Region: PRK06247 698963004431 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 698963004432 domain interfaces; other site 698963004433 active site 698963004434 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 698963004435 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698963004436 active site 698963004437 ribulose/triose binding site [chemical binding]; other site 698963004438 phosphate binding site [ion binding]; other site 698963004439 substrate (anthranilate) binding pocket [chemical binding]; other site 698963004440 product (indole) binding pocket [chemical binding]; other site 698963004441 trp region conserved hypothetical membrane protein; Region: trp_oprn_chp; TIGR02234 698963004442 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 698963004443 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 698963004444 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698963004445 substrate binding site [chemical binding]; other site 698963004446 glutamase interaction surface [polypeptide binding]; other site 698963004447 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698963004448 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698963004449 active site 698963004450 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 698963004451 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698963004452 catalytic residues [active] 698963004453 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 698963004454 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 698963004455 putative active site [active] 698963004456 oxyanion strand; other site 698963004457 catalytic triad [active] 698963004458 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698963004459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698963004460 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 698963004461 putative active site pocket [active] 698963004462 4-fold oligomerization interface [polypeptide binding]; other site 698963004463 metal binding residues [ion binding]; metal-binding site 698963004464 3-fold/trimer interface [polypeptide binding]; other site 698963004465 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 698963004466 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698963004467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698963004468 homodimer interface [polypeptide binding]; other site 698963004469 catalytic residue [active] 698963004470 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 698963004471 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 698963004472 NAD binding site [chemical binding]; other site 698963004473 dimerization interface [polypeptide binding]; other site 698963004474 product binding site; other site 698963004475 substrate binding site [chemical binding]; other site 698963004476 zinc binding site [ion binding]; other site 698963004477 catalytic residues [active] 698963004478 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 698963004479 tetracycline repressor protein TetR; Provisional; Region: PRK13756 698963004480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698963004481 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 698963004482 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 698963004483 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 698963004484 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 698963004485 active site 698963004486 catalytic site [active] 698963004487 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 698963004488 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 698963004489 active site 698963004490 catalytic site [active] 698963004491 substrate binding site [chemical binding]; other site 698963004492 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698963004493 synthetase active site [active] 698963004494 NTP binding site [chemical binding]; other site 698963004495 metal binding site [ion binding]; metal-binding site 698963004496 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698963004497 RNA binding surface [nucleotide binding]; other site 698963004498 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 698963004499 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 698963004500 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 698963004501 threonine dehydratase; Validated; Region: PRK08639 698963004502 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698963004503 tetramer interface [polypeptide binding]; other site 698963004504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698963004505 catalytic residue [active] 698963004506 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 698963004507 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 698963004508 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 698963004509 active site 698963004510 PHP Thumb interface [polypeptide binding]; other site 698963004511 metal binding site [ion binding]; metal-binding site 698963004512 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698963004513 generic binding surface II; other site 698963004514 generic binding surface I; other site 698963004515 Predicted permeases [General function prediction only]; Region: RarD; COG2962 698963004516 EamA-like transporter family; Region: EamA; cl17759 698963004517 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 698963004518 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698963004519 RNA binding surface [nucleotide binding]; other site 698963004520 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698963004521 active site 698963004522 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 698963004523 lipoprotein signal peptidase; Provisional; Region: PRK14787 698963004524 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698963004525 active site 698963004526 homotetramer interface [polypeptide binding]; other site 698963004527 homodimer interface [polypeptide binding]; other site 698963004528 DNA polymerase IV; Provisional; Region: PRK03348 698963004529 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 698963004530 active site 698963004531 DNA binding site [nucleotide binding] 698963004532 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 698963004533 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698963004534 HIGH motif; other site 698963004535 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698963004536 active site 698963004537 KMSKS motif; other site 698963004538 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 698963004539 tRNA binding surface [nucleotide binding]; other site 698963004540 anticodon binding site; other site 698963004541 DivIVA domain; Region: DivI1A_domain; TIGR03544 698963004542 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698963004543 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 698963004544 YGGT family; Region: YGGT; cl00508 698963004545 Protein of unknown function (DUF552); Region: DUF552; cl00775 698963004546 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 698963004547 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 698963004548 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 698963004549 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 698963004550 nucleotide binding site [chemical binding]; other site 698963004551 SulA interaction site; other site 698963004552 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 698963004553 Cell division protein FtsQ; Region: FtsQ; pfam03799 698963004554 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 698963004555 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698963004556 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698963004557 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698963004558 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 698963004559 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 698963004560 active site 698963004561 homodimer interface [polypeptide binding]; other site 698963004562 cell division protein FtsW; Region: ftsW; TIGR02614 698963004563 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 698963004564 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698963004565 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698963004566 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 698963004567 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 698963004568 Mg++ binding site [ion binding]; other site 698963004569 putative catalytic motif [active] 698963004570 putative substrate binding site [chemical binding]; other site 698963004571 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 698963004572 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698963004573 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698963004574 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698963004575 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 698963004576 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698963004577 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698963004578 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698963004579 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698963004580 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698963004581 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698963004582 MraW methylase family; Region: Methyltransf_5; cl17771 698963004583 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 698963004584 cell division protein MraZ; Reviewed; Region: PRK00326 698963004585 MraZ protein; Region: MraZ; pfam02381 698963004586 MraZ protein; Region: MraZ; pfam02381 698963004587 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698963004588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698963004589 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698963004590 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 698963004591 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698963004592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698963004593 Coenzyme A binding pocket [chemical binding]; other site 698963004594 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 698963004595 FAD binding site [chemical binding]; other site 698963004596 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698963004597 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698963004598 substrate binding pocket [chemical binding]; other site 698963004599 chain length determination region; other site 698963004600 substrate-Mg2+ binding site; other site 698963004601 catalytic residues [active] 698963004602 aspartate-rich region 1; other site 698963004603 active site lid residues [active] 698963004604 aspartate-rich region 2; other site 698963004605 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698963004606 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698963004607 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698963004608 active site 698963004609 ATP binding site [chemical binding]; other site 698963004610 substrate binding site [chemical binding]; other site 698963004611 activation loop (A-loop); other site 698963004612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698963004613 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698963004614 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698963004615 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698963004616 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698963004617 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 698963004618 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698963004619 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698963004620 putative acyl-acceptor binding pocket; other site 698963004621 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698963004622 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698963004623 nucleotide binding site [chemical binding]; other site 698963004624 Tesmin/TSO1-like CXC domain; Region: CXC; pfam03638 698963004625 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698963004626 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698963004627 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698963004628 NlpC/P60 family; Region: NLPC_P60; pfam00877 698963004629 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698963004630 NlpC/P60 family; Region: NLPC_P60; pfam00877 698963004631 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 698963004632 heme bH binding site [chemical binding]; other site 698963004633 intrachain domain interface; other site 698963004634 heme bL binding site [chemical binding]; other site 698963004635 interchain domain interface [polypeptide binding]; other site 698963004636 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 698963004637 Qo binding site; other site 698963004638 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 698963004639 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698963004640 iron-sulfur cluster [ion binding]; other site 698963004641 [2Fe-2S] cluster binding site [ion binding]; other site 698963004642 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698963004643 Cytochrome c; Region: Cytochrom_C; pfam00034 698963004644 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698963004645 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 698963004646 Subunit I/III interface [polypeptide binding]; other site 698963004647 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 698963004648 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 698963004649 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 698963004650 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 698963004651 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 698963004652 active site 698963004653 dimer interface [polypeptide binding]; other site 698963004654 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 698963004655 Ligand Binding Site [chemical binding]; other site 698963004656 Molecular Tunnel; other site 698963004657 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 698963004658 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 698963004659 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 698963004660 homotrimer interface [polypeptide binding]; other site 698963004661 Walker A motif; other site 698963004662 GTP binding site [chemical binding]; other site 698963004663 Walker B motif; other site 698963004664 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 698963004665 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 698963004666 putative dimer interface [polypeptide binding]; other site 698963004667 active site pocket [active] 698963004668 putative cataytic base [active] 698963004669 cobalamin synthase; Reviewed; Region: cobS; PRK00235 698963004670 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 698963004671 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 698963004672 homodimer interface [polypeptide binding]; other site 698963004673 substrate-cofactor binding pocket; other site 698963004674 catalytic residue [active] 698963004675 multifunctional aminopeptidase A; Provisional; Region: PRK00913 698963004676 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 698963004677 interface (dimer of trimers) [polypeptide binding]; other site 698963004678 Substrate-binding/catalytic site; other site 698963004679 Zn-binding sites [ion binding]; other site 698963004680 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 698963004681 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698963004682 E3 interaction surface; other site 698963004683 lipoyl attachment site [posttranslational modification]; other site 698963004684 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698963004685 E3 interaction surface; other site 698963004686 lipoyl attachment site [posttranslational modification]; other site 698963004687 e3 binding domain; Region: E3_binding; pfam02817 698963004688 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698963004689 lipoate-protein ligase B; Provisional; Region: PRK14345 698963004690 lipoyl synthase; Provisional; Region: PRK05481 698963004691 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698963004692 FeS/SAM binding site; other site 698963004693 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 698963004694 RDD family; Region: RDD; pfam06271 698963004695 glutamine synthetase, type I; Region: GlnA; TIGR00653 698963004696 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698963004697 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698963004698 Predicted peptidase [General function prediction only]; Region: COG4099 698963004699 CsbD-like; Region: CsbD; pfam05532 698963004700 Predicted permease [General function prediction only]; Region: COG2056 698963004701 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 698963004702 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698963004703 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698963004704 DNA-binding site [nucleotide binding]; DNA binding site 698963004705 FCD domain; Region: FCD; pfam07729 698963004706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698963004707 putative substrate translocation pore; other site 698963004708 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 698963004709 nudix motif; other site 698963004710 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 698963004711 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 698963004712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698963004713 catalytic residue [active] 698963004714 active site 698963004715 catalytic site [active] 698963004716 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 698963004717 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 698963004718 heme binding pocket [chemical binding]; other site 698963004719 heme ligand [chemical binding]; other site 698963004720 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 698963004721 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698963004722 metal binding triad; other site 698963004723 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698963004724 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698963004725 metal binding triad; other site 698963004726 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698963004727 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 698963004728 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698963004729 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698963004730 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 698963004731 putative active site; other site 698963004732 putative metal binding residues [ion binding]; other site 698963004733 signature motif; other site 698963004734 putative triphosphate binding site [ion binding]; other site 698963004735 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 698963004736 galactokinase; Provisional; Region: PRK00555 698963004737 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698963004738 RNB domain; Region: RNB; pfam00773 698963004739 Predicted membrane protein [General function prediction only]; Region: COG4194 698963004740 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 698963004741 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 698963004742 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 698963004743 RNA/DNA hybrid binding site [nucleotide binding]; other site 698963004744 active site 698963004745 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698963004746 catalytic core [active] 698963004747 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 698963004748 Putative zinc ribbon domain; Region: DUF164; pfam02591 698963004749 Uncharacterized conserved protein [Function unknown]; Region: COG0327 698963004750 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698963004751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 698963004752 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698963004753 hypothetical protein; Provisional; Region: PRK07908 698963004754 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698963004755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698963004756 homodimer interface [polypeptide binding]; other site 698963004757 catalytic residue [active] 698963004758 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 698963004759 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698963004760 motif II; other site 698963004761 Low molecular weight phosphatase family; Region: LMWPc; cd00115 698963004762 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 698963004763 active site 698963004764 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 698963004765 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 698963004766 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 698963004767 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 698963004768 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 698963004769 dimer interface [polypeptide binding]; other site 698963004770 TPP-binding site [chemical binding]; other site 698963004771 Electron transfer DM13; Region: DM13; pfam10517 698963004772 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698963004773 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698963004774 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698963004775 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 698963004776 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698963004777 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698963004778 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698963004779 active site 698963004780 motif I; other site 698963004781 motif II; other site 698963004782 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698963004783 motif II; other site 698963004784 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698963004785 Beta-lactamase; Region: Beta-lactamase; pfam00144 698963004786 Predicted membrane protein [Function unknown]; Region: COG2860 698963004787 UPF0126 domain; Region: UPF0126; pfam03458 698963004788 UPF0126 domain; Region: UPF0126; pfam03458 698963004789 DNA primase; Validated; Region: dnaG; PRK05667 698963004790 CHC2 zinc finger; Region: zf-CHC2; pfam01807 698963004791 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 698963004792 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 698963004793 active site 698963004794 metal binding site [ion binding]; metal-binding site 698963004795 interdomain interaction site; other site 698963004796 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 698963004797 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 698963004798 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 698963004799 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 698963004800 glutaminase active site [active] 698963004801 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698963004802 dimer interface [polypeptide binding]; other site 698963004803 active site 698963004804 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 698963004805 dimer interface [polypeptide binding]; other site 698963004806 active site 698963004807 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 698963004808 active site 698963004809 barstar interaction site; other site 698963004810 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 698963004811 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698963004812 Zn2+ binding site [ion binding]; other site 698963004813 Mg2+ binding site [ion binding]; other site 698963004814 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 698963004815 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698963004816 putative active site [active] 698963004817 Repair protein; Region: Repair_PSII; pfam04536 698963004818 glycyl-tRNA synthetase; Provisional; Region: PRK04173 698963004819 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698963004820 motif 1; other site 698963004821 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 698963004822 active site 698963004823 motif 2; other site 698963004824 motif 3; other site 698963004825 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 698963004826 anticodon binding site; other site 698963004827 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698963004828 MULE transposase domain; Region: MULE; pfam10551 698963004829 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698963004830 putative DNA binding site [nucleotide binding]; other site 698963004831 dimerization interface [polypeptide binding]; other site 698963004832 putative Zn2+ binding site [ion binding]; other site 698963004833 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698963004834 metal binding site 2 [ion binding]; metal-binding site 698963004835 putative DNA binding helix; other site 698963004836 metal binding site 1 [ion binding]; metal-binding site 698963004837 dimer interface [polypeptide binding]; other site 698963004838 structural Zn2+ binding site [ion binding]; other site 698963004839 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 698963004840 diiron binding motif [ion binding]; other site 698963004841 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 698963004842 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698963004843 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 698963004844 catalytic residue [active] 698963004845 putative FPP diphosphate binding site; other site 698963004846 putative FPP binding hydrophobic cleft; other site 698963004847 dimer interface [polypeptide binding]; other site 698963004848 putative IPP diphosphate binding site; other site 698963004849 Recombination protein O N terminal; Region: RecO_N; pfam11967 698963004850 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 698963004851 Recombination protein O C terminal; Region: RecO_C; pfam02565 698963004852 GTPase Era; Reviewed; Region: era; PRK00089 698963004853 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 698963004854 G1 box; other site 698963004855 GTP/Mg2+ binding site [chemical binding]; other site 698963004856 Switch I region; other site 698963004857 G2 box; other site 698963004858 Switch II region; other site 698963004859 G3 box; other site 698963004860 G4 box; other site 698963004861 G5 box; other site 698963004862 KH domain; Region: KH_2; pfam07650 698963004863 pyridoxamine kinase; Validated; Region: PRK05756 698963004864 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 698963004865 dimer interface [polypeptide binding]; other site 698963004866 pyridoxal binding site [chemical binding]; other site 698963004867 ATP binding site [chemical binding]; other site 698963004868 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698963004869 Domain of unknown function DUF21; Region: DUF21; pfam01595 698963004870 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698963004871 Transporter associated domain; Region: CorC_HlyC; smart01091 698963004872 metal-binding heat shock protein; Provisional; Region: PRK00016 698963004873 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 698963004874 PhoH-like protein; Region: PhoH; pfam02562 698963004875 RNA methyltransferase, RsmE family; Region: TIGR00046 698963004876 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 698963004877 chaperone protein DnaJ; Provisional; Region: PRK14278 698963004878 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698963004879 HSP70 interaction site [polypeptide binding]; other site 698963004880 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698963004881 Zn binding sites [ion binding]; other site 698963004882 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698963004883 dimer interface [polypeptide binding]; other site 698963004884 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 698963004885 coproporphyrinogen III oxidase; Validated; Region: PRK05628 698963004886 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698963004887 FeS/SAM binding site; other site 698963004888 HemN C-terminal domain; Region: HemN_C; pfam06969 698963004889 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698963004890 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698963004891 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698963004892 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698963004893 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 698963004894 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 698963004895 acyl-activating enzyme (AAE) consensus motif; other site 698963004896 putative AMP binding site [chemical binding]; other site 698963004897 putative active site [active] 698963004898 putative CoA binding site [chemical binding]; other site 698963004899 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 698963004900 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 698963004901 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 698963004902 active site 698963004903 Zn binding site [ion binding]; other site 698963004904 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698963004905 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698963004906 substrate binding pocket [chemical binding]; other site 698963004907 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 698963004908 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 698963004909 active site 698963004910 metal binding site [ion binding]; metal-binding site 698963004911 nudix motif; other site 698963004912 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698963004913 active site 698963004914 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698963004915 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698963004916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963004917 Walker A/P-loop; other site 698963004918 ATP binding site [chemical binding]; other site 698963004919 Q-loop/lid; other site 698963004920 ABC transporter signature motif; other site 698963004921 Walker B; other site 698963004922 D-loop; other site 698963004923 H-loop/switch region; other site 698963004924 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 698963004925 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698963004926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698963004927 homodimer interface [polypeptide binding]; other site 698963004928 catalytic residue [active] 698963004929 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 698963004930 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698963004931 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 698963004932 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698963004933 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 698963004934 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698963004935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698963004936 dimer interface [polypeptide binding]; other site 698963004937 conserved gate region; other site 698963004938 putative PBP binding loops; other site 698963004939 ABC-ATPase subunit interface; other site 698963004940 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698963004941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698963004942 dimer interface [polypeptide binding]; other site 698963004943 conserved gate region; other site 698963004944 putative PBP binding loops; other site 698963004945 ABC-ATPase subunit interface; other site 698963004946 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698963004947 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698963004948 Walker A/P-loop; other site 698963004949 ATP binding site [chemical binding]; other site 698963004950 Q-loop/lid; other site 698963004951 ABC transporter signature motif; other site 698963004952 Walker B; other site 698963004953 D-loop; other site 698963004954 H-loop/switch region; other site 698963004955 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698963004956 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698963004957 Walker A/P-loop; other site 698963004958 ATP binding site [chemical binding]; other site 698963004959 Q-loop/lid; other site 698963004960 ABC transporter signature motif; other site 698963004961 Walker B; other site 698963004962 D-loop; other site 698963004963 H-loop/switch region; other site 698963004964 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698963004965 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 698963004966 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 698963004967 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698963004968 catalytic residue [active] 698963004969 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698963004970 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698963004971 nucleotide binding site [chemical binding]; other site 698963004972 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 698963004973 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698963004974 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698963004975 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 698963004976 active site residue [active] 698963004977 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 698963004978 putative homodimer interface [polypeptide binding]; other site 698963004979 putative homotetramer interface [polypeptide binding]; other site 698963004980 putative allosteric switch controlling residues; other site 698963004981 putative metal binding site [ion binding]; other site 698963004982 putative homodimer-homodimer interface [polypeptide binding]; other site 698963004983 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 698963004984 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698963004985 TrkA-N domain; Region: TrkA_N; pfam02254 698963004986 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 698963004987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698963004988 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 698963004989 active site 698963004990 tetramer interface [polypeptide binding]; other site 698963004991 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698963004992 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 698963004993 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698963004994 Mrr N-terminal domain; Region: Mrr_N; pfam14338 698963004995 Restriction endonuclease; Region: Mrr_cat; pfam04471 698963004996 Abi-like protein; Region: Abi_2; pfam07751 698963004997 GTP-binding protein LepA; Provisional; Region: PRK05433 698963004998 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 698963004999 G1 box; other site 698963005000 putative GEF interaction site [polypeptide binding]; other site 698963005001 GTP/Mg2+ binding site [chemical binding]; other site 698963005002 Switch I region; other site 698963005003 G2 box; other site 698963005004 G3 box; other site 698963005005 Switch II region; other site 698963005006 G4 box; other site 698963005007 G5 box; other site 698963005008 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 698963005009 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 698963005010 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 698963005011 PemK-like protein; Region: PemK; pfam02452 698963005012 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 698963005013 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698963005014 hypothetical protein; Validated; Region: PRK05629 698963005015 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 698963005016 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 698963005017 Competence protein; Region: Competence; pfam03772 698963005018 comEA protein; Region: comE; TIGR01259 698963005019 Helix-hairpin-helix motif; Region: HHH; pfam00633 698963005020 helix-hairpin-helix signature motif; other site 698963005021 EDD domain protein, DegV family; Region: DegV; TIGR00762 698963005022 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 698963005023 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698963005024 catalytic core [active] 698963005025 Oligomerisation domain; Region: Oligomerisation; cl00519 698963005026 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 698963005027 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 698963005028 active site 698963005029 (T/H)XGH motif; other site 698963005030 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 698963005031 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 698963005032 putative catalytic cysteine [active] 698963005033 gamma-glutamyl kinase; Provisional; Region: PRK05429 698963005034 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 698963005035 nucleotide binding site [chemical binding]; other site 698963005036 homotetrameric interface [polypeptide binding]; other site 698963005037 putative phosphate binding site [ion binding]; other site 698963005038 putative allosteric binding site; other site 698963005039 PUA domain; Region: PUA; pfam01472 698963005040 GTPase CgtA; Reviewed; Region: obgE; PRK12296 698963005041 GTP1/OBG; Region: GTP1_OBG; pfam01018 698963005042 Obg GTPase; Region: Obg; cd01898 698963005043 G1 box; other site 698963005044 GTP/Mg2+ binding site [chemical binding]; other site 698963005045 Switch I region; other site 698963005046 G2 box; other site 698963005047 G3 box; other site 698963005048 Switch II region; other site 698963005049 G4 box; other site 698963005050 G5 box; other site 698963005051 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 698963005052 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 698963005053 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 698963005054 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 698963005055 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698963005056 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 698963005057 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 698963005058 homodimer interface [polypeptide binding]; other site 698963005059 oligonucleotide binding site [chemical binding]; other site 698963005060 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 698963005061 active site 698963005062 multimer interface [polypeptide binding]; other site 698963005063 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 698963005064 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 698963005065 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698963005066 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 698963005067 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698963005068 active site 698963005069 HIGH motif; other site 698963005070 nucleotide binding site [chemical binding]; other site 698963005071 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698963005072 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 698963005073 active site 698963005074 KMSKS motif; other site 698963005075 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 698963005076 tRNA binding surface [nucleotide binding]; other site 698963005077 anticodon binding site; other site 698963005078 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 698963005079 malate dehydrogenase; Provisional; Region: PRK05442 698963005080 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 698963005081 NAD(P) binding site [chemical binding]; other site 698963005082 dimer interface [polypeptide binding]; other site 698963005083 malate binding site [chemical binding]; other site 698963005084 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698963005085 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698963005086 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 698963005087 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 698963005088 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 698963005089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698963005090 Walker A motif; other site 698963005091 ATP binding site [chemical binding]; other site 698963005092 Walker B motif; other site 698963005093 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 698963005094 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698963005095 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698963005096 glutamine binding [chemical binding]; other site 698963005097 catalytic triad [active] 698963005098 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 698963005099 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698963005100 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 698963005101 substrate-cofactor binding pocket; other site 698963005102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698963005103 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 698963005104 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698963005105 oligomer interface [polypeptide binding]; other site 698963005106 active site residues [active] 698963005107 Clp protease; Region: CLP_protease; pfam00574 698963005108 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698963005109 oligomer interface [polypeptide binding]; other site 698963005110 active site residues [active] 698963005111 trigger factor; Provisional; Region: tig; PRK01490 698963005112 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698963005113 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 698963005114 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 698963005115 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698963005116 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698963005117 catalytic residues [active] 698963005118 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 698963005119 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 698963005120 Zn binding site [ion binding]; other site 698963005121 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698963005122 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698963005123 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698963005124 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 698963005125 apolar tunnel; other site 698963005126 heme binding site [chemical binding]; other site 698963005127 dimerization interface [polypeptide binding]; other site 698963005128 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698963005129 active site 698963005130 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 698963005131 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963005132 Walker A/P-loop; other site 698963005133 ATP binding site [chemical binding]; other site 698963005134 Q-loop/lid; other site 698963005135 ABC transporter signature motif; other site 698963005136 Walker B; other site 698963005137 D-loop; other site 698963005138 H-loop/switch region; other site 698963005139 ABC transporter; Region: ABC_tran_2; pfam12848 698963005140 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698963005141 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698963005142 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698963005143 dimer interface [polypeptide binding]; other site 698963005144 ssDNA binding site [nucleotide binding]; other site 698963005145 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698963005146 Copper resistance protein D; Region: CopD; pfam05425 698963005147 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 698963005148 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 698963005149 Carbon starvation protein CstA; Region: CstA; pfam02554 698963005150 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 698963005151 Protein of unknown function (DUF466); Region: DUF466; pfam04328 698963005152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698963005153 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698963005154 putative substrate translocation pore; other site 698963005155 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 698963005156 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 698963005157 NADP binding site [chemical binding]; other site 698963005158 dimer interface [polypeptide binding]; other site 698963005159 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698963005160 classical (c) SDRs; Region: SDR_c; cd05233 698963005161 NAD(P) binding site [chemical binding]; other site 698963005162 active site 698963005163 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 698963005164 catalytic site [active] 698963005165 putative active site [active] 698963005166 putative substrate binding site [chemical binding]; other site 698963005167 dimer interface [polypeptide binding]; other site 698963005168 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698963005169 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698963005170 inhibitor site; inhibition site 698963005171 active site 698963005172 dimer interface [polypeptide binding]; other site 698963005173 catalytic residue [active] 698963005174 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 698963005175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698963005176 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 698963005177 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698963005178 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 698963005179 MULE transposase domain; Region: MULE; pfam10551 698963005180 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 698963005181 conserved cis-peptide bond; other site 698963005182 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 698963005183 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 698963005184 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698963005185 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 698963005186 catalytic triad [active] 698963005187 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698963005188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698963005189 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 698963005190 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698963005191 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 698963005192 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698963005193 phosphate binding site [ion binding]; other site 698963005194 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 698963005195 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 698963005196 active site 2 [active] 698963005197 active site 1 [active] 698963005198 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 698963005199 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698963005200 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 698963005201 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 698963005202 putative NAD(P) binding site [chemical binding]; other site 698963005203 active site 698963005204 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 698963005205 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 698963005206 active site 698963005207 Glucitol operon activator protein (GutM); Region: GutM; cl01890 698963005208 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 698963005209 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 698963005210 active site 698963005211 dimerization interface [polypeptide binding]; other site 698963005212 ribonuclease PH; Reviewed; Region: rph; PRK00173 698963005213 Ribonuclease PH; Region: RNase_PH_bact; cd11362 698963005214 hexamer interface [polypeptide binding]; other site 698963005215 active site 698963005216 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 698963005217 glutamate racemase; Provisional; Region: PRK00865 698963005218 Rhomboid family; Region: Rhomboid; cl11446 698963005219 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 698963005220 putative active site pocket [active] 698963005221 cleavage site 698963005222 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 698963005223 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 698963005224 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 698963005225 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 698963005226 active site 698963005227 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 698963005228 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698963005229 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698963005230 putative Mg++ binding site [ion binding]; other site 698963005231 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 698963005232 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698963005233 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698963005234 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698963005235 active site 698963005236 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 698963005237 dimer interface [polypeptide binding]; other site 698963005238 putative active site [active] 698963005239 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 698963005240 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 698963005241 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 698963005242 phosphoserine phosphatase SerB; Region: serB; TIGR00338 698963005243 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698963005244 motif II; other site 698963005245 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 698963005246 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 698963005247 D-pathway; other site 698963005248 Putative ubiquinol binding site [chemical binding]; other site 698963005249 Low-spin heme (heme b) binding site [chemical binding]; other site 698963005250 Putative water exit pathway; other site 698963005251 Binuclear center (heme o3/CuB) [ion binding]; other site 698963005252 K-pathway; other site 698963005253 Putative proton exit pathway; other site 698963005254 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698963005255 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698963005256 dimer interface [polypeptide binding]; other site 698963005257 putative radical transfer pathway; other site 698963005258 diiron center [ion binding]; other site 698963005259 tyrosyl radical; other site 698963005260 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 698963005261 Ferritin-like domain; Region: Ferritin; pfam00210 698963005262 ferroxidase diiron center [ion binding]; other site 698963005263 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 698963005264 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 698963005265 Class I ribonucleotide reductase; Region: RNR_I; cd01679 698963005266 active site 698963005267 dimer interface [polypeptide binding]; other site 698963005268 catalytic residues [active] 698963005269 effector binding site; other site 698963005270 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698963005271 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698963005272 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698963005273 catalytic residues [active] 698963005274 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 698963005275 active site lid residues [active] 698963005276 substrate binding pocket [chemical binding]; other site 698963005277 catalytic residues [active] 698963005278 substrate-Mg2+ binding site; other site 698963005279 aspartate-rich region 1; other site 698963005280 aspartate-rich region 2; other site 698963005281 phytoene desaturase; Region: crtI_fam; TIGR02734 698963005282 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698963005283 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 698963005284 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 698963005285 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 698963005286 homodimer interface [polypeptide binding]; other site 698963005287 NAD binding pocket [chemical binding]; other site 698963005288 ATP binding pocket [chemical binding]; other site 698963005289 Mg binding site [ion binding]; other site 698963005290 active-site loop [active] 698963005291 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 698963005292 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 698963005293 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 698963005294 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 698963005295 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 698963005296 Predicted transcriptional regulator [Transcription]; Region: COG2345 698963005297 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 698963005298 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 698963005299 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698963005300 catalytic residues [active] 698963005301 Methylamine utilisation protein MauE; Region: MauE; pfam07291 698963005302 phosphoglucomutase; Validated; Region: PRK07564 698963005303 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 698963005304 active site 698963005305 substrate binding site [chemical binding]; other site 698963005306 metal binding site [ion binding]; metal-binding site 698963005307 CrcB-like protein; Region: CRCB; pfam02537 698963005308 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698963005309 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698963005310 FtsX-like permease family; Region: FtsX; pfam02687 698963005311 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698963005312 FtsX-like permease family; Region: FtsX; pfam02687 698963005313 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698963005314 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698963005315 Walker A/P-loop; other site 698963005316 ATP binding site [chemical binding]; other site 698963005317 Q-loop/lid; other site 698963005318 ABC transporter signature motif; other site 698963005319 Walker B; other site 698963005320 D-loop; other site 698963005321 H-loop/switch region; other site 698963005322 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698963005323 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698963005324 hinge; other site 698963005325 active site 698963005326 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 698963005327 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 698963005328 GAF domain; Region: GAF_2; pfam13185 698963005329 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698963005330 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698963005331 DNA binding residues [nucleotide binding] 698963005332 dimerization interface [polypeptide binding]; other site 698963005333 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698963005334 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698963005335 dimer interface [polypeptide binding]; other site 698963005336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698963005337 catalytic residue [active] 698963005338 serine O-acetyltransferase; Region: cysE; TIGR01172 698963005339 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 698963005340 trimer interface [polypeptide binding]; other site 698963005341 active site 698963005342 substrate binding site [chemical binding]; other site 698963005343 CoA binding site [chemical binding]; other site 698963005344 Predicted acetyltransferase [General function prediction only]; Region: COG2388 698963005345 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 698963005346 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 698963005347 putative active site [active] 698963005348 metal binding site [ion binding]; metal-binding site 698963005349 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 698963005350 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698963005351 Walker A/P-loop; other site 698963005352 ATP binding site [chemical binding]; other site 698963005353 Q-loop/lid; other site 698963005354 ABC transporter signature motif; other site 698963005355 Walker B; other site 698963005356 D-loop; other site 698963005357 H-loop/switch region; other site 698963005358 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 698963005359 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698963005360 intersubunit interface [polypeptide binding]; other site 698963005361 ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism]; Region: FepD; COG0609 698963005362 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698963005363 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698963005364 ABC-ATPase subunit interface; other site 698963005365 dimer interface [polypeptide binding]; other site 698963005366 putative PBP binding regions; other site 698963005367 HTH-like domain; Region: HTH_21; pfam13276 698963005368 Integrase core domain; Region: rve; pfam00665 698963005369 potential frameshift: common BLAST hit: gi|38234527|ref|NP_940294.1| transposase 698963005370 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698963005371 HTH-like domain; Region: HTH_21; pfam13276 698963005372 Integrase core domain; Region: rve; pfam00665 698963005373 Integrase core domain; Region: rve_2; pfam13333 698963005374 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 698963005375 Cadmium resistance transporter; Region: Cad; pfam03596 698963005376 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698963005377 dimerization interface [polypeptide binding]; other site 698963005378 putative DNA binding site [nucleotide binding]; other site 698963005379 putative Zn2+ binding site [ion binding]; other site 698963005380 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 698963005381 SdpI/YhfL protein family; Region: SdpI; pfam13630 698963005382 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 698963005383 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 698963005384 HTH-like domain; Region: HTH_21; pfam13276 698963005385 Integrase core domain; Region: rve; pfam00665 698963005386 Integrase core domain; Region: rve_3; cl15866 698963005387 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 698963005388 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 698963005389 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698963005390 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698963005391 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 698963005392 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963005393 Walker A/P-loop; other site 698963005394 ATP binding site [chemical binding]; other site 698963005395 Q-loop/lid; other site 698963005396 ABC transporter signature motif; other site 698963005397 Walker B; other site 698963005398 D-loop; other site 698963005399 H-loop/switch region; other site 698963005400 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 698963005401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963005402 Walker A/P-loop; other site 698963005403 ATP binding site [chemical binding]; other site 698963005404 Q-loop/lid; other site 698963005405 ABC transporter signature motif; other site 698963005406 Walker B; other site 698963005407 D-loop; other site 698963005408 H-loop/switch region; other site 698963005409 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 698963005410 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 698963005411 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 698963005412 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 698963005413 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 698963005414 FMN binding site [chemical binding]; other site 698963005415 active site 698963005416 catalytic residues [active] 698963005417 substrate binding site [chemical binding]; other site 698963005418 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 698963005419 PhoU domain; Region: PhoU; pfam01895 698963005420 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 698963005421 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 698963005422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698963005423 Coenzyme A binding pocket [chemical binding]; other site 698963005424 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698963005425 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698963005426 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 698963005427 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 698963005428 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 698963005429 heme-binding site [chemical binding]; other site 698963005430 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 698963005431 substrate binding site [chemical binding]; other site 698963005432 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 698963005433 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 698963005434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698963005435 catalytic residue [active] 698963005436 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 698963005437 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 698963005438 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698963005439 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 698963005440 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 698963005441 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 698963005442 dimerization interface [polypeptide binding]; other site 698963005443 putative ATP binding site [chemical binding]; other site 698963005444 amidophosphoribosyltransferase; Provisional; Region: PRK07847 698963005445 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 698963005446 active site 698963005447 tetramer interface [polypeptide binding]; other site 698963005448 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698963005449 active site 698963005450 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 698963005451 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 698963005452 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698963005453 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698963005454 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698963005455 dimer interface [polypeptide binding]; other site 698963005456 putative radical transfer pathway; other site 698963005457 diiron center [ion binding]; other site 698963005458 tyrosyl radical; other site 698963005459 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 698963005460 catalytic residues [active] 698963005461 dimer interface [polypeptide binding]; other site 698963005462 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 698963005463 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698963005464 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 698963005465 ATP binding site [chemical binding]; other site 698963005466 active site 698963005467 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 698963005468 substrate binding site [chemical binding]; other site 698963005469 adenylosuccinate lyase; Region: purB; TIGR00928 698963005470 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 698963005471 tetramer interface [polypeptide binding]; other site 698963005472 aspartate aminotransferase; Provisional; Region: PRK05764 698963005473 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698963005474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698963005475 homodimer interface [polypeptide binding]; other site 698963005476 catalytic residue [active] 698963005477 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 698963005478 TrkA-N domain; Region: TrkA_N; pfam02254 698963005479 TrkA-C domain; Region: TrkA_C; pfam02080 698963005480 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 698963005481 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 698963005482 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 698963005483 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 698963005484 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 698963005485 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 698963005486 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 698963005487 nucleotide binding site/active site [active] 698963005488 HIT family signature motif; other site 698963005489 catalytic residue [active] 698963005490 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 698963005491 PGAP1-like protein; Region: PGAP1; pfam07819 698963005492 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698963005493 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698963005494 dimerization interface [polypeptide binding]; other site 698963005495 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698963005496 dimer interface [polypeptide binding]; other site 698963005497 phosphorylation site [posttranslational modification] 698963005498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698963005499 ATP binding site [chemical binding]; other site 698963005500 Mg2+ binding site [ion binding]; other site 698963005501 G-X-G motif; other site 698963005502 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698963005503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698963005504 active site 698963005505 phosphorylation site [posttranslational modification] 698963005506 intermolecular recognition site; other site 698963005507 dimerization interface [polypeptide binding]; other site 698963005508 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698963005509 DNA binding site [nucleotide binding] 698963005510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698963005511 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698963005512 putative substrate translocation pore; other site 698963005513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698963005514 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698963005515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698963005516 xanthine permease; Region: pbuX; TIGR03173 698963005517 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 698963005518 pyruvate dehydrogenase; Provisional; Region: PRK06546 698963005519 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 698963005520 PYR/PP interface [polypeptide binding]; other site 698963005521 dimer interface [polypeptide binding]; other site 698963005522 tetramer interface [polypeptide binding]; other site 698963005523 TPP binding site [chemical binding]; other site 698963005524 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698963005525 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 698963005526 TPP-binding site [chemical binding]; other site 698963005527 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698963005528 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 698963005529 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698963005530 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698963005531 Uncharacterized conserved protein [Function unknown]; Region: COG3610 698963005532 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 698963005533 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 698963005534 active site 698963005535 homotetramer interface [polypeptide binding]; other site 698963005536 META domain; Region: META; cl01245 698963005537 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 698963005538 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 698963005539 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698963005540 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698963005541 DNA binding site [nucleotide binding] 698963005542 domain linker motif; other site 698963005543 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 698963005544 putative dimerization interface [polypeptide binding]; other site 698963005545 putative ligand binding site [chemical binding]; other site 698963005546 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698963005547 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 698963005548 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698963005549 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 698963005550 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698963005551 active site 698963005552 HIGH motif; other site 698963005553 nucleotide binding site [chemical binding]; other site 698963005554 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698963005555 KMSKS motif; other site 698963005556 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698963005557 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 698963005558 homotrimer interaction site [polypeptide binding]; other site 698963005559 zinc binding site [ion binding]; other site 698963005560 CDP-binding sites; other site 698963005561 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 698963005562 substrate binding site; other site 698963005563 dimer interface; other site 698963005564 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 698963005565 DNA repair protein RadA; Provisional; Region: PRK11823 698963005566 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698963005567 Walker A motif; other site 698963005568 ATP binding site [chemical binding]; other site 698963005569 Walker B motif; other site 698963005570 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698963005571 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 698963005572 active site clefts [active] 698963005573 zinc binding site [ion binding]; other site 698963005574 dimer interface [polypeptide binding]; other site 698963005575 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698963005576 endonuclease III; Region: ENDO3c; smart00478 698963005577 minor groove reading motif; other site 698963005578 helix-hairpin-helix signature motif; other site 698963005579 substrate binding pocket [chemical binding]; other site 698963005580 active site 698963005581 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698963005582 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698963005583 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 698963005584 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 698963005585 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 698963005586 Clp amino terminal domain; Region: Clp_N; pfam02861 698963005587 Clp amino terminal domain; Region: Clp_N; pfam02861 698963005588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698963005589 Walker A motif; other site 698963005590 ATP binding site [chemical binding]; other site 698963005591 Walker B motif; other site 698963005592 arginine finger; other site 698963005593 UvrB/uvrC motif; Region: UVR; pfam02151 698963005594 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698963005595 Walker A motif; other site 698963005596 ATP binding site [chemical binding]; other site 698963005597 Walker B motif; other site 698963005598 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698963005599 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 698963005600 oligomer interface [polypeptide binding]; other site 698963005601 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698963005602 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698963005603 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 698963005604 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698963005605 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698963005606 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 698963005607 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 698963005608 active site 698963005609 catalytic motif [active] 698963005610 Zn binding site [ion binding]; other site 698963005611 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 698963005612 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 698963005613 Nucleoside recognition; Region: Gate; pfam07670 698963005614 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 698963005615 Transposase; Region: DDE_Tnp_ISL3; pfam01610 698963005616 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 698963005617 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698963005618 dimer interface [polypeptide binding]; other site 698963005619 putative anticodon binding site; other site 698963005620 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698963005621 motif 1; other site 698963005622 dimer interface [polypeptide binding]; other site 698963005623 active site 698963005624 motif 2; other site 698963005625 motif 3; other site 698963005626 YcaO-like family; Region: YcaO; pfam02624 698963005627 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 698963005628 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 698963005629 NADPH bind site [chemical binding]; other site 698963005630 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 698963005631 dimer interface [polypeptide binding]; other site 698963005632 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 698963005633 SpaB C-terminal domain; Region: SpaB_C; pfam14028 698963005634 YcaO-like family; Region: YcaO; pfam02624 698963005635 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 698963005636 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698963005637 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698963005638 Walker A/P-loop; other site 698963005639 ATP binding site [chemical binding]; other site 698963005640 Q-loop/lid; other site 698963005641 ABC transporter signature motif; other site 698963005642 Walker B; other site 698963005643 D-loop; other site 698963005644 H-loop/switch region; other site 698963005645 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698963005646 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 698963005647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 698963005648 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698963005649 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698963005650 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698963005651 active site 698963005652 KMSKS motif; other site 698963005653 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 698963005654 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 698963005655 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 698963005656 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 698963005657 catalytic center binding site [active] 698963005658 ATP binding site [chemical binding]; other site 698963005659 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 698963005660 homooctamer interface [polypeptide binding]; other site 698963005661 active site 698963005662 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698963005663 dihydropteroate synthase; Region: DHPS; TIGR01496 698963005664 substrate binding pocket [chemical binding]; other site 698963005665 dimer interface [polypeptide binding]; other site 698963005666 inhibitor binding site; inhibition site 698963005667 Protein of unknown function, DUF393; Region: DUF393; pfam04134 698963005668 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 698963005669 homodecamer interface [polypeptide binding]; other site 698963005670 GTP cyclohydrolase I; Provisional; Region: PLN03044 698963005671 active site 698963005672 putative catalytic site residues [active] 698963005673 zinc binding site [ion binding]; other site 698963005674 GTP-CH-I/GFRP interaction surface; other site 698963005675 FtsH Extracellular; Region: FtsH_ext; pfam06480 698963005676 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 698963005677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698963005678 Walker A motif; other site 698963005679 ATP binding site [chemical binding]; other site 698963005680 Walker B motif; other site 698963005681 arginine finger; other site 698963005682 Peptidase family M41; Region: Peptidase_M41; pfam01434 698963005683 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698963005684 active site 698963005685 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 698963005686 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 698963005687 Ligand Binding Site [chemical binding]; other site 698963005688 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 698963005689 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 698963005690 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 698963005691 dimer interface [polypeptide binding]; other site 698963005692 substrate binding site [chemical binding]; other site 698963005693 metal binding sites [ion binding]; metal-binding site 698963005694 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698963005695 active site residue [active] 698963005696 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698963005697 MarR family; Region: MarR_2; pfam12802 698963005698 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698963005699 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 698963005700 acyl-activating enzyme (AAE) consensus motif; other site 698963005701 AMP binding site [chemical binding]; other site 698963005702 active site 698963005703 CoA binding site [chemical binding]; other site 698963005704 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698963005705 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 698963005706 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698963005707 putative trimer interface [polypeptide binding]; other site 698963005708 putative CoA binding site [chemical binding]; other site 698963005709 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698963005710 putative trimer interface [polypeptide binding]; other site 698963005711 putative CoA binding site [chemical binding]; other site 698963005712 potential frameshift: common BLAST hit: gi|38234579|ref|NP_940346.1| exported lipase 698963005713 Secretory lipase; Region: LIP; pfam03583 698963005714 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698963005715 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 698963005716 active site 698963005717 catalytic triad [active] 698963005718 oxyanion hole [active] 698963005719 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698963005720 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698963005721 ring oligomerisation interface [polypeptide binding]; other site 698963005722 ATP/Mg binding site [chemical binding]; other site 698963005723 stacking interactions; other site 698963005724 hinge regions; other site 698963005725 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698963005726 MULE transposase domain; Region: MULE; pfam10551 698963005727 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698963005728 MULE transposase domain; Region: MULE; pfam10551 698963005729 hypothetical protein; Provisional; Region: PRK07907 698963005730 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 698963005731 active site 698963005732 metal binding site [ion binding]; metal-binding site 698963005733 dimer interface [polypeptide binding]; other site 698963005734 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698963005735 carboxylate-amine ligase; Provisional; Region: PRK13517 698963005736 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 698963005737 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698963005738 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698963005739 active site 698963005740 catalytic residues [active] 698963005741 metal binding site [ion binding]; metal-binding site 698963005742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698963005743 Coenzyme A binding pocket [chemical binding]; other site 698963005744 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698963005745 putative catalytic site [active] 698963005746 putative metal binding site [ion binding]; other site 698963005747 putative phosphate binding site [ion binding]; other site 698963005748 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 698963005749 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 698963005750 putative active site [active] 698963005751 catalytic site [active] 698963005752 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 698963005753 putative active site [active] 698963005754 catalytic site [active] 698963005755 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698963005756 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698963005757 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963005758 Walker A/P-loop; other site 698963005759 ATP binding site [chemical binding]; other site 698963005760 Q-loop/lid; other site 698963005761 ABC transporter signature motif; other site 698963005762 Walker B; other site 698963005763 D-loop; other site 698963005764 H-loop/switch region; other site 698963005765 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698963005766 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698963005767 substrate binding pocket [chemical binding]; other site 698963005768 membrane-bound complex binding site; other site 698963005769 hinge residues; other site 698963005770 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698963005771 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698963005772 active site 698963005773 ATP binding site [chemical binding]; other site 698963005774 substrate binding site [chemical binding]; other site 698963005775 activation loop (A-loop); other site 698963005776 propionate/acetate kinase; Provisional; Region: PRK12379 698963005777 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 698963005778 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 698963005779 ferredoxin-NADP+ reductase; Region: PLN02852 698963005780 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698963005781 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698963005782 Coenzyme A binding pocket [chemical binding]; other site 698963005783 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698963005784 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 698963005785 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698963005786 active site 698963005787 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698963005788 putative active site [active] 698963005789 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 698963005790 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 698963005791 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 698963005792 GDP-binding site [chemical binding]; other site 698963005793 ACT binding site; other site 698963005794 IMP binding site; other site 698963005795 Predicted membrane protein [Function unknown]; Region: COG4129 698963005796 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698963005797 chromosome segregation protein; Provisional; Region: PRK03918 698963005798 Predicted membrane protein [Function unknown]; Region: COG4129 698963005799 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698963005800 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 698963005801 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698963005802 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 698963005803 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698963005804 Transposase; Region: HTH_Tnp_1; pfam01527 698963005805 Integrase core domain; Region: rve; pfam00665 698963005806 Integrase core domain; Region: rve_3; cl15866 698963005807 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698963005808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963005809 Walker A/P-loop; other site 698963005810 ATP binding site [chemical binding]; other site 698963005811 Q-loop/lid; other site 698963005812 ABC transporter signature motif; other site 698963005813 Walker B; other site 698963005814 D-loop; other site 698963005815 H-loop/switch region; other site 698963005816 HTH-like domain; Region: HTH_21; pfam13276 698963005817 Integrase core domain; Region: rve; pfam00665 698963005818 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698963005819 Helix-turn-helix domain; Region: HTH_38; pfam13936 698963005820 Integrase core domain; Region: rve; pfam00665 698963005821 HTH-like domain; Region: HTH_21; pfam13276 698963005822 Integrase core domain; Region: rve; pfam00665 698963005823 Transposase; Region: HTH_Tnp_1; cl17663 698963005824 HTH-like domain; Region: HTH_21; pfam13276 698963005825 Integrase core domain; Region: rve; pfam00665 698963005826 Integrase core domain; Region: rve_3; pfam13683 698963005827 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698963005828 NADH(P)-binding; Region: NAD_binding_10; pfam13460 698963005829 NAD(P) binding site [chemical binding]; other site 698963005830 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698963005831 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 698963005832 Condensation domain; Region: Condensation; pfam00668 698963005833 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698963005834 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698963005835 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 698963005836 acyl-activating enzyme (AAE) consensus motif; other site 698963005837 AMP binding site [chemical binding]; other site 698963005838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698963005839 S-adenosylmethionine binding site [chemical binding]; other site 698963005840 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698963005841 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698963005842 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 698963005843 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698963005844 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 698963005845 acyl-activating enzyme (AAE) consensus motif; other site 698963005846 AMP binding site [chemical binding]; other site 698963005847 active site 698963005848 CoA binding site [chemical binding]; other site 698963005849 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698963005850 Condensation domain; Region: Condensation; pfam00668 698963005851 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698963005852 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698963005853 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 698963005854 acyl-activating enzyme (AAE) consensus motif; other site 698963005855 AMP binding site [chemical binding]; other site 698963005856 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698963005857 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698963005858 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698963005859 Condensation domain; Region: Condensation; pfam00668 698963005860 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698963005861 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698963005862 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 698963005863 acyl-activating enzyme (AAE) consensus motif; other site 698963005864 AMP binding site [chemical binding]; other site 698963005865 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698963005866 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 698963005867 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698963005868 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698963005869 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698963005870 Walker A/P-loop; other site 698963005871 ATP binding site [chemical binding]; other site 698963005872 Q-loop/lid; other site 698963005873 ABC transporter signature motif; other site 698963005874 Walker B; other site 698963005875 D-loop; other site 698963005876 H-loop/switch region; other site 698963005877 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698963005878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963005879 Walker A/P-loop; other site 698963005880 ATP binding site [chemical binding]; other site 698963005881 Q-loop/lid; other site 698963005882 ABC transporter signature motif; other site 698963005883 Walker B; other site 698963005884 D-loop; other site 698963005885 H-loop/switch region; other site 698963005886 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698963005887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963005888 Walker A/P-loop; other site 698963005889 ATP binding site [chemical binding]; other site 698963005890 Q-loop/lid; other site 698963005891 ABC transporter signature motif; other site 698963005892 Walker B; other site 698963005893 D-loop; other site 698963005894 H-loop/switch region; other site 698963005895 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698963005896 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963005897 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698963005898 Walker A/P-loop; other site 698963005899 ATP binding site [chemical binding]; other site 698963005900 Q-loop/lid; other site 698963005901 ABC transporter signature motif; other site 698963005902 Walker B; other site 698963005903 D-loop; other site 698963005904 H-loop/switch region; other site 698963005905 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 698963005906 Anticodon binding domain of tRNAs; Region: HGTP_anticodon2; pfam12745 698963005907 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 698963005908 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 698963005909 homodimer interface [polypeptide binding]; other site 698963005910 active site 698963005911 TDP-binding site; other site 698963005912 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 698963005913 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 698963005914 active site 698963005915 substrate binding site [chemical binding]; other site 698963005916 trimer interface [polypeptide binding]; other site 698963005917 CoA binding site [chemical binding]; other site 698963005918 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963005919 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 698963005920 Walker A/P-loop; other site 698963005921 ATP binding site [chemical binding]; other site 698963005922 Q-loop/lid; other site 698963005923 ABC transporter signature motif; other site 698963005924 Walker B; other site 698963005925 D-loop; other site 698963005926 H-loop/switch region; other site 698963005927 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 698963005928 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698963005929 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698963005930 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698963005931 Integrase core domain; Region: rve_3; pfam13683 698963005932 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698963005933 Helix-turn-helix domain; Region: HTH_38; pfam13936 698963005934 Integrase core domain; Region: rve; pfam00665 698963005935 HTH-like domain; Region: HTH_21; pfam13276 698963005936 TQXA domain; Region: TQXA_dom; TIGR03934 698963005937 Integrase core domain; Region: rve; pfam00665 698963005938 Integrase core domain; Region: rve_2; pfam13333 698963005939 Winged helix-turn helix; Region: HTH_29; pfam13551 698963005940 Helix-turn-helix domain; Region: HTH_28; pfam13518 698963005941 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 698963005942 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 698963005943 active site 698963005944 intersubunit interface [polypeptide binding]; other site 698963005945 zinc binding site [ion binding]; other site 698963005946 Na+ binding site [ion binding]; other site 698963005947 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 698963005948 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698963005949 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698963005950 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698963005951 active site 698963005952 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698963005953 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698963005954 active site residue [active] 698963005955 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698963005956 active site residue [active] 698963005957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698963005958 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 698963005959 Clp amino terminal domain; Region: Clp_N; pfam02861 698963005960 Clp amino terminal domain; Region: Clp_N; pfam02861 698963005961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698963005962 Walker A motif; other site 698963005963 ATP binding site [chemical binding]; other site 698963005964 Walker B motif; other site 698963005965 arginine finger; other site 698963005966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698963005967 Walker A motif; other site 698963005968 ATP binding site [chemical binding]; other site 698963005969 Walker B motif; other site 698963005970 arginine finger; other site 698963005971 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698963005972 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698963005973 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 698963005974 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698963005975 Walker A/P-loop; other site 698963005976 ATP binding site [chemical binding]; other site 698963005977 Q-loop/lid; other site 698963005978 ABC transporter signature motif; other site 698963005979 Walker B; other site 698963005980 D-loop; other site 698963005981 H-loop/switch region; other site 698963005982 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698963005983 EamA-like transporter family; Region: EamA; pfam00892 698963005984 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698963005985 EamA-like transporter family; Region: EamA; pfam00892 698963005986 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 698963005987 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 698963005988 FAD binding pocket [chemical binding]; other site 698963005989 FAD binding motif [chemical binding]; other site 698963005990 phosphate binding motif [ion binding]; other site 698963005991 beta-alpha-beta structure motif; other site 698963005992 NAD binding pocket [chemical binding]; other site 698963005993 Predicted amidohydrolase [General function prediction only]; Region: COG0388 698963005994 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 698963005995 putative active site [active] 698963005996 catalytic triad [active] 698963005997 putative dimer interface [polypeptide binding]; other site 698963005998 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 698963005999 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 698963006000 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 698963006001 NAD binding site [chemical binding]; other site 698963006002 substrate binding site [chemical binding]; other site 698963006003 catalytic Zn binding site [ion binding]; other site 698963006004 tetramer interface [polypeptide binding]; other site 698963006005 structural Zn binding site [ion binding]; other site 698963006006 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698963006007 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698963006008 NAD(P) binding site [chemical binding]; other site 698963006009 catalytic residues [active] 698963006010 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 698963006011 DNA binding residues [nucleotide binding] 698963006012 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698963006013 putative dimer interface [polypeptide binding]; other site 698963006014 chaperone protein DnaJ; Provisional; Region: PRK14279 698963006015 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698963006016 HSP70 interaction site [polypeptide binding]; other site 698963006017 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698963006018 Zn binding sites [ion binding]; other site 698963006019 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698963006020 dimer interface [polypeptide binding]; other site 698963006021 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 698963006022 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 698963006023 dimer interface [polypeptide binding]; other site 698963006024 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 698963006025 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 698963006026 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 698963006027 nucleotide binding site [chemical binding]; other site 698963006028 NEF interaction site [polypeptide binding]; other site 698963006029 SBD interface [polypeptide binding]; other site 698963006030 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698963006031 PAS domain; Region: PAS_9; pfam13426 698963006032 putative active site [active] 698963006033 heme pocket [chemical binding]; other site 698963006034 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698963006035 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698963006036 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698963006037 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698963006038 Walker A/P-loop; other site 698963006039 ATP binding site [chemical binding]; other site 698963006040 Q-loop/lid; other site 698963006041 ABC transporter signature motif; other site 698963006042 Walker B; other site 698963006043 D-loop; other site 698963006044 H-loop/switch region; other site 698963006045 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698963006046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698963006047 dimer interface [polypeptide binding]; other site 698963006048 conserved gate region; other site 698963006049 putative PBP binding loops; other site 698963006050 ABC-ATPase subunit interface; other site 698963006051 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698963006052 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 698963006053 Walker A/P-loop; other site 698963006054 ATP binding site [chemical binding]; other site 698963006055 Q-loop/lid; other site 698963006056 ABC transporter signature motif; other site 698963006057 Walker B; other site 698963006058 D-loop; other site 698963006059 H-loop/switch region; other site 698963006060 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698963006061 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698963006062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698963006063 dimer interface [polypeptide binding]; other site 698963006064 conserved gate region; other site 698963006065 putative PBP binding loops; other site 698963006066 ABC-ATPase subunit interface; other site 698963006067 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698963006068 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 698963006069 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698963006070 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698963006071 ferredoxin-NADP+ reductase; Region: PLN02852 698963006072 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698963006073 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 698963006074 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 698963006075 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 698963006076 dimerization interface [polypeptide binding]; other site 698963006077 ATP binding site [chemical binding]; other site 698963006078 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 698963006079 dimerization interface [polypeptide binding]; other site 698963006080 ATP binding site [chemical binding]; other site 698963006081 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 698963006082 putative active site [active] 698963006083 catalytic triad [active] 698963006084 potential frameshift: common BLAST hit: gi|68535225|ref|YP_249930.1| acetyl-CoA acetyltransferase 698963006085 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 698963006086 active site 698963006087 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698963006088 substrate binding site [chemical binding]; other site 698963006089 oxyanion hole (OAH) forming residues; other site 698963006090 trimer interface [polypeptide binding]; other site 698963006091 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 698963006092 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 698963006093 active site 698963006094 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 698963006095 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 698963006096 FAD binding pocket [chemical binding]; other site 698963006097 FAD binding motif [chemical binding]; other site 698963006098 phosphate binding motif [ion binding]; other site 698963006099 NAD binding pocket [chemical binding]; other site 698963006100 Siderophore-interacting protein; Region: SIP; pfam04954 698963006101 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698963006102 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698963006103 Walker A/P-loop; other site 698963006104 ATP binding site [chemical binding]; other site 698963006105 Q-loop/lid; other site 698963006106 ABC transporter signature motif; other site 698963006107 Walker B; other site 698963006108 D-loop; other site 698963006109 H-loop/switch region; other site 698963006110 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698963006111 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698963006112 ABC-ATPase subunit interface; other site 698963006113 dimer interface [polypeptide binding]; other site 698963006114 putative PBP binding regions; other site 698963006115 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698963006116 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698963006117 ABC-ATPase subunit interface; other site 698963006118 dimer interface [polypeptide binding]; other site 698963006119 putative PBP binding regions; other site 698963006120 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 698963006121 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698963006122 siderophore binding site; other site 698963006123 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 698963006124 ferredoxin-NADP+ reductase; Region: PLN02852 698963006125 Permease; Region: Permease; cl00510 698963006126 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698963006127 4Fe-4S binding domain; Region: Fer4; cl02805 698963006128 Cysteine-rich domain; Region: CCG; pfam02754 698963006129 Cysteine-rich domain; Region: CCG; pfam02754 698963006130 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 698963006131 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698963006132 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 698963006133 putative NAD(P) binding site [chemical binding]; other site 698963006134 catalytic Zn binding site [ion binding]; other site 698963006135 aminotransferase AlaT; Validated; Region: PRK09265 698963006136 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698963006137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698963006138 homodimer interface [polypeptide binding]; other site 698963006139 catalytic residue [active] 698963006140 YibE/F-like protein; Region: YibE_F; pfam07907 698963006141 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 698963006142 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 698963006143 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698963006144 dimer interface [polypeptide binding]; other site 698963006145 putative anticodon binding site; other site 698963006146 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698963006147 motif 1; other site 698963006148 dimer interface [polypeptide binding]; other site 698963006149 active site 698963006150 motif 2; other site 698963006151 motif 3; other site 698963006152 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698963006153 Protein of unknown function (DUF998); Region: DUF998; pfam06197 698963006154 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 698963006155 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 698963006156 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 698963006157 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698963006158 trimer interface [polypeptide binding]; other site 698963006159 active site 698963006160 Prophage antirepressor [Transcription]; Region: COG3617 698963006161 BRO family, N-terminal domain; Region: Bro-N; smart01040 698963006162 Abi-like protein; Region: Abi_2; cl01988 698963006163 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 698963006164 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698963006165 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698963006166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963006167 Walker A/P-loop; other site 698963006168 ATP binding site [chemical binding]; other site 698963006169 Q-loop/lid; other site 698963006170 ABC transporter signature motif; other site 698963006171 Walker B; other site 698963006172 D-loop; other site 698963006173 H-loop/switch region; other site 698963006174 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698963006175 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963006176 Walker A/P-loop; other site 698963006177 ATP binding site [chemical binding]; other site 698963006178 Q-loop/lid; other site 698963006179 ABC transporter signature motif; other site 698963006180 Walker B; other site 698963006181 D-loop; other site 698963006182 H-loop/switch region; other site 698963006183 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698963006184 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 698963006185 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698963006186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698963006187 dimer interface [polypeptide binding]; other site 698963006188 conserved gate region; other site 698963006189 putative PBP binding loops; other site 698963006190 ABC-ATPase subunit interface; other site 698963006191 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698963006192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698963006193 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698963006194 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 698963006195 Walker A/P-loop; other site 698963006196 ATP binding site [chemical binding]; other site 698963006197 Q-loop/lid; other site 698963006198 ABC transporter signature motif; other site 698963006199 Walker B; other site 698963006200 D-loop; other site 698963006201 H-loop/switch region; other site 698963006202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963006203 Walker A/P-loop; other site 698963006204 ATP binding site [chemical binding]; other site 698963006205 Q-loop/lid; other site 698963006206 ABC transporter signature motif; other site 698963006207 Walker B; other site 698963006208 D-loop; other site 698963006209 H-loop/switch region; other site 698963006210 metabolite-proton symporter; Region: 2A0106; TIGR00883 698963006211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698963006212 putative substrate translocation pore; other site 698963006213 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698963006214 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698963006215 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 698963006216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698963006217 putative substrate translocation pore; other site 698963006218 YwiC-like protein; Region: YwiC; pfam14256 698963006219 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698963006220 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698963006221 VanW like protein; Region: VanW; pfam04294 698963006222 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 698963006223 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 698963006224 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 698963006225 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698963006226 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698963006227 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698963006228 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698963006229 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698963006230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698963006231 S-adenosylmethionine binding site [chemical binding]; other site 698963006232 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 698963006233 active site 698963006234 substrate-binding site [chemical binding]; other site 698963006235 metal-binding site [ion binding] 698963006236 GTP binding site [chemical binding]; other site 698963006237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698963006238 S-adenosylmethionine binding site [chemical binding]; other site 698963006239 LabA_like proteins; Region: LabA_like; cd06167 698963006240 putative metal binding site [ion binding]; other site 698963006241 MMPL family; Region: MMPL; pfam03176 698963006242 MMPL family; Region: MMPL; pfam03176 698963006243 Predicted integral membrane protein [Function unknown]; Region: COG0392 698963006244 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 698963006245 TQXA domain; Region: TQXA_dom; TIGR03934 698963006246 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 698963006247 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 698963006248 active site 698963006249 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698963006250 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698963006251 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698963006252 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698963006253 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 698963006254 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 698963006255 active site 698963006256 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 698963006257 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 698963006258 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698963006259 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 698963006260 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 698963006261 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 698963006262 acyl-activating enzyme (AAE) consensus motif; other site 698963006263 active site 698963006264 Cutinase; Region: Cutinase; pfam01083 698963006265 Putative esterase; Region: Esterase; pfam00756 698963006266 S-formylglutathione hydrolase; Region: PLN02442 698963006267 LGFP repeat; Region: LGFP; pfam08310 698963006268 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698963006269 LGFP repeat; Region: LGFP; pfam08310 698963006270 LGFP repeat; Region: LGFP; pfam08310 698963006271 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698963006272 Predicted esterase [General function prediction only]; Region: COG0627 698963006273 S-formylglutathione hydrolase; Region: PLN02442 698963006274 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 698963006275 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 698963006276 UbiA prenyltransferase family; Region: UbiA; pfam01040 698963006277 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698963006278 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698963006279 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698963006280 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698963006281 active site 698963006282 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698963006283 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698963006284 NAD(P) binding site [chemical binding]; other site 698963006285 catalytic residues [active] 698963006286 BCCT family transporter; Region: BCCT; cl00569 698963006287 choline dehydrogenase; Validated; Region: PRK02106 698963006288 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698963006289 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 698963006290 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698963006291 UDP-galactopyranose mutase; Region: GLF; pfam03275 698963006292 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 698963006293 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 698963006294 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963006295 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698963006296 ABC transporter signature motif; other site 698963006297 Walker B; other site 698963006298 D-loop; other site 698963006299 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 698963006300 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 698963006301 DNA-binding interface [nucleotide binding]; DNA binding site 698963006302 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 698963006303 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 698963006304 Integrase core domain; Region: rve; pfam00665 698963006305 SdpI/YhfL protein family; Region: SdpI; pfam13630 698963006306 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 698963006307 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 698963006308 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012 698963006309 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698963006310 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698963006311 active site 698963006312 catalytic tetrad [active] 698963006313 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698963006314 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698963006315 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698963006316 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698963006317 amidase catalytic site [active] 698963006318 Zn binding residues [ion binding]; other site 698963006319 substrate binding site [chemical binding]; other site 698963006320 LGFP repeat; Region: LGFP; pfam08310 698963006321 RloB-like protein; Region: RloB; pfam13707 698963006322 Predicted ATPases [General function prediction only]; Region: COG1106 698963006323 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963006324 Walker A/P-loop; other site 698963006325 ATP binding site [chemical binding]; other site 698963006326 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963006327 Q-loop/lid; other site 698963006328 ABC transporter signature motif; other site 698963006329 Walker B; other site 698963006330 D-loop; other site 698963006331 H-loop/switch region; other site 698963006332 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698963006333 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 698963006334 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698963006335 HsdM N-terminal domain; Region: HsdM_N; pfam12161 698963006336 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 698963006337 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698963006338 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 698963006339 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 698963006340 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698963006341 ATP binding site [chemical binding]; other site 698963006342 putative Mg++ binding site [ion binding]; other site 698963006343 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 698963006344 ATP-binding site [chemical binding]; other site 698963006345 glycerol kinase; Provisional; Region: glpK; PRK00047 698963006346 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 698963006347 N- and C-terminal domain interface [polypeptide binding]; other site 698963006348 active site 698963006349 MgATP binding site [chemical binding]; other site 698963006350 catalytic site [active] 698963006351 metal binding site [ion binding]; metal-binding site 698963006352 putative homotetramer interface [polypeptide binding]; other site 698963006353 glycerol binding site [chemical binding]; other site 698963006354 homodimer interface [polypeptide binding]; other site 698963006355 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 698963006356 amphipathic channel; other site 698963006357 Asn-Pro-Ala signature motifs; other site 698963006358 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 698963006359 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698963006360 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698963006361 putative acyl-acceptor binding pocket; other site 698963006362 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698963006363 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698963006364 active site 698963006365 motif I; other site 698963006366 motif II; other site 698963006367 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698963006368 seryl-tRNA synthetase; Provisional; Region: PRK05431 698963006369 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 698963006370 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 698963006371 dimer interface [polypeptide binding]; other site 698963006372 active site 698963006373 motif 1; other site 698963006374 motif 2; other site 698963006375 motif 3; other site 698963006376 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698963006377 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698963006378 DNA-binding site [nucleotide binding]; DNA binding site 698963006379 UTRA domain; Region: UTRA; pfam07702 698963006380 Septum formation; Region: Septum_form; pfam13845 698963006381 Septum formation; Region: Septum_form; pfam13845 698963006382 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 698963006383 AAA domain; Region: AAA_14; pfam13173 698963006384 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 698963006385 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698963006386 catalytic core [active] 698963006387 prephenate dehydratase; Provisional; Region: PRK11898 698963006388 Prephenate dehydratase; Region: PDT; pfam00800 698963006389 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 698963006390 putative L-Phe binding site [chemical binding]; other site 698963006391 Amidase; Region: Amidase; cl11426 698963006392 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698963006393 CAAX protease self-immunity; Region: Abi; pfam02517 698963006394 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 698963006395 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698963006396 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698963006397 amino acid carrier protein; Region: agcS; TIGR00835 698963006398 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698963006399 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 698963006400 catalytic triad [active] 698963006401 catalytic triad [active] 698963006402 oxyanion hole [active] 698963006403 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698963006404 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 698963006405 putative active site [active] 698963006406 catalytic site [active] 698963006407 putative metal binding site [ion binding]; other site 698963006408 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 698963006409 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 698963006410 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698963006411 NAD binding site [chemical binding]; other site 698963006412 dimer interface [polypeptide binding]; other site 698963006413 substrate binding site [chemical binding]; other site 698963006414 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 698963006415 nudix motif; other site 698963006416 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 698963006417 quinolinate synthetase; Provisional; Region: PRK09375 698963006418 L-aspartate oxidase; Provisional; Region: PRK06175 698963006419 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 698963006420 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 698963006421 dimerization interface [polypeptide binding]; other site 698963006422 active site 698963006423 methionine sulfoxide reductase A; Provisional; Region: PRK00058 698963006424 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 698963006425 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 698963006426 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 698963006427 Predicted flavoprotein [General function prediction only]; Region: COG0431 698963006428 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698963006429 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 698963006430 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 698963006431 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698963006432 Lsr2; Region: Lsr2; pfam11774 698963006433 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698963006434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698963006435 active site 698963006436 phosphorylation site [posttranslational modification] 698963006437 intermolecular recognition site; other site 698963006438 dimerization interface [polypeptide binding]; other site 698963006439 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698963006440 DNA binding residues [nucleotide binding] 698963006441 dimerization interface [polypeptide binding]; other site 698963006442 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698963006443 Histidine kinase; Region: HisKA_3; pfam07730 698963006444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698963006445 ATP binding site [chemical binding]; other site 698963006446 Mg2+ binding site [ion binding]; other site 698963006447 G-X-G motif; other site 698963006448 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 698963006449 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 698963006450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698963006451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698963006452 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 698963006453 active site 698963006454 catalytic site [active] 698963006455 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 698963006456 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 698963006457 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698963006458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698963006459 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698963006460 Ligand Binding Site [chemical binding]; other site 698963006461 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698963006462 Ligand Binding Site [chemical binding]; other site 698963006463 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 698963006464 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698963006465 probable active site [active] 698963006466 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698963006467 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963006468 Walker A/P-loop; other site 698963006469 ATP binding site [chemical binding]; other site 698963006470 Q-loop/lid; other site 698963006471 ABC transporter signature motif; other site 698963006472 Walker B; other site 698963006473 D-loop; other site 698963006474 H-loop/switch region; other site 698963006475 Predicted transcriptional regulators [Transcription]; Region: COG1725 698963006476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698963006477 DNA-binding site [nucleotide binding]; DNA binding site 698963006478 LabA_like proteins; Region: LabA_like; cd06167 698963006479 putative metal binding site [ion binding]; other site 698963006480 Uncharacterized conserved protein [Function unknown]; Region: COG1432 698963006481 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698963006482 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698963006483 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698963006484 catalytic residues [active] 698963006485 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698963006486 metal-binding site [ion binding] 698963006487 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698963006488 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698963006489 metal-binding site [ion binding] 698963006490 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698963006491 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698963006492 benzoate transport; Region: 2A0115; TIGR00895 698963006493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698963006494 putative substrate translocation pore; other site 698963006495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698963006496 replicative DNA helicase; Provisional; Region: PRK05636 698963006497 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 698963006498 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 698963006499 Walker A motif; other site 698963006500 ATP binding site [chemical binding]; other site 698963006501 Walker B motif; other site 698963006502 DNA binding loops [nucleotide binding] 698963006503 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 698963006504 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 698963006505 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 698963006506 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698963006507 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698963006508 dimer interface [polypeptide binding]; other site 698963006509 ssDNA binding site [nucleotide binding]; other site 698963006510 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698963006511 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 698963006512 Predicted integral membrane protein [Function unknown]; Region: COG5650 698963006513 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698963006514 Transglycosylase; Region: Transgly; pfam00912 698963006515 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698963006516 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 698963006517 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698963006518 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698963006519 Ligand Binding Site [chemical binding]; other site 698963006520 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698963006521 Ligand Binding Site [chemical binding]; other site 698963006522 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698963006523 classical (c) SDRs; Region: SDR_c; cd05233 698963006524 NAD(P) binding site [chemical binding]; other site 698963006525 active site 698963006526 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 698963006527 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 698963006528 active site residue [active] 698963006529 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 698963006530 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698963006531 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 698963006532 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 698963006533 dimerization interface [polypeptide binding]; other site 698963006534 DPS ferroxidase diiron center [ion binding]; other site 698963006535 ion pore; other site 698963006536 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698963006537 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 698963006538 putative DNA binding site [nucleotide binding]; other site 698963006539 catalytic residue [active] 698963006540 putative H2TH interface [polypeptide binding]; other site 698963006541 putative catalytic residues [active] 698963006542 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698963006543 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698963006544 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 698963006545 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 698963006546 putative substrate binding site [chemical binding]; other site 698963006547 putative ATP binding site [chemical binding]; other site 698963006548 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 698963006549 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 698963006550 active site 698963006551 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698963006552 AAA domain; Region: AAA_31; pfam13614 698963006553 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698963006554 P-loop; other site 698963006555 Magnesium ion binding site [ion binding]; other site 698963006556 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698963006557 Magnesium ion binding site [ion binding]; other site 698963006558 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 698963006559 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 698963006560 putative ligand binding residues [chemical binding]; other site 698963006561 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698963006562 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698963006563 ABC-ATPase subunit interface; other site 698963006564 dimer interface [polypeptide binding]; other site 698963006565 putative PBP binding regions; other site 698963006566 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698963006567 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698963006568 Walker A/P-loop; other site 698963006569 ATP binding site [chemical binding]; other site 698963006570 Q-loop/lid; other site 698963006571 ABC transporter signature motif; other site 698963006572 Walker B; other site 698963006573 D-loop; other site 698963006574 H-loop/switch region; other site 698963006575 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 698963006576 dimer interface [polypeptide binding]; other site 698963006577 [2Fe-2S] cluster binding site [ion binding]; other site 698963006578 Divergent AAA domain; Region: AAA_4; pfam04326 698963006579 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698963006580 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698963006581 Divergent AAA domain; Region: AAA_4; pfam04326 698963006582 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698963006583 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698963006584 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 698963006585 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698963006586 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698963006587 ATP binding site [chemical binding]; other site 698963006588 putative Mg++ binding site [ion binding]; other site 698963006589 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 698963006590 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698963006591 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 698963006592 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698963006593 HsdM N-terminal domain; Region: HsdM_N; pfam12161 698963006594 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 698963006595 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698963006596 Fic family protein [Function unknown]; Region: COG3177 698963006597 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698963006598 Fic/DOC family; Region: Fic; pfam02661 698963006599 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 698963006600 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 698963006601 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 698963006602 E-class dimer interface [polypeptide binding]; other site 698963006603 P-class dimer interface [polypeptide binding]; other site 698963006604 active site 698963006605 Cu2+ binding site [ion binding]; other site 698963006606 Zn2+ binding site [ion binding]; other site 698963006607 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 698963006608 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698963006609 active site 698963006610 HIGH motif; other site 698963006611 nucleotide binding site [chemical binding]; other site 698963006612 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698963006613 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698963006614 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698963006615 active site 698963006616 KMSKS motif; other site 698963006617 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 698963006618 tRNA binding surface [nucleotide binding]; other site 698963006619 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698963006620 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698963006621 Walker A/P-loop; other site 698963006622 ATP binding site [chemical binding]; other site 698963006623 Q-loop/lid; other site 698963006624 ABC transporter signature motif; other site 698963006625 Walker B; other site 698963006626 D-loop; other site 698963006627 H-loop/switch region; other site 698963006628 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698963006629 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698963006630 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698963006631 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698963006632 Histidine kinase; Region: HisKA_3; pfam07730 698963006633 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698963006634 ATP binding site [chemical binding]; other site 698963006635 G-X-G motif; other site 698963006636 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698963006637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698963006638 active site 698963006639 phosphorylation site [posttranslational modification] 698963006640 intermolecular recognition site; other site 698963006641 dimerization interface [polypeptide binding]; other site 698963006642 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698963006643 DNA binding residues [nucleotide binding] 698963006644 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698963006645 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698963006646 Predicted membrane protein [Function unknown]; Region: COG1511 698963006647 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698963006648 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698963006649 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698963006650 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698963006651 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698963006652 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698963006653 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 698963006654 NAD(P) binding site [chemical binding]; other site 698963006655 catalytic residues [active] 698963006656 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698963006657 active site 698963006658 phosphorylation site [posttranslational modification] 698963006659 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 698963006660 active site 698963006661 P-loop; other site 698963006662 phosphorylation site [posttranslational modification] 698963006663 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 698963006664 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 698963006665 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 698963006666 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 698963006667 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 698963006668 active site 698963006669 active pocket/dimerization site; other site 698963006670 phosphorylation site [posttranslational modification] 698963006671 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698963006672 dimerization domain swap beta strand [polypeptide binding]; other site 698963006673 regulatory protein interface [polypeptide binding]; other site 698963006674 active site 698963006675 regulatory phosphorylation site [posttranslational modification]; other site 698963006676 Predicted ATPases [General function prediction only]; Region: COG1106 698963006677 Herpesvirus UL46 protein; Region: Herpes_UL46; cl17368 698963006678 Putative esterase; Region: Esterase; pfam00756 698963006679 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 698963006680 active site 698963006681 Cobalt transport protein; Region: CbiQ; cl00463 698963006682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963006683 ABC transporter signature motif; other site 698963006684 Walker B; other site 698963006685 D-loop; other site 698963006686 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698963006687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698963006688 Walker A/P-loop; other site 698963006689 ATP binding site [chemical binding]; other site 698963006690 Q-loop/lid; other site 698963006691 ABC transporter signature motif; other site 698963006692 Walker B; other site 698963006693 D-loop; other site 698963006694 H-loop/switch region; other site 698963006695 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 698963006696 active site 698963006697 catalytic residues [active] 698963006698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 698963006699 hypothetical protein; Provisional; Region: PRK13663 698963006700 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698963006701 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698963006702 putative active site [active] 698963006703 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698963006704 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698963006705 SdpI/YhfL protein family; Region: SdpI; pfam13630 698963006706 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698963006707 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698963006708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698963006709 catalytic residue [active] 698963006710 potential frameshift: common BLAST hit: gi|38234886|ref|NP_940653.1| anthranilate synthase component I 698963006711 anthranilate synthase component I; Provisional; Region: PRK13564 698963006712 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 698963006713 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 698963006714 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698963006715 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698963006716 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698963006717 glutamine binding [chemical binding]; other site 698963006718 catalytic triad [active] 698963006719 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 698963006720 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698963006721 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698963006722 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 698963006723 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698963006724 active site 698963006725 ribulose/triose binding site [chemical binding]; other site 698963006726 phosphate binding site [ion binding]; other site 698963006727 substrate (anthranilate) binding pocket [chemical binding]; other site 698963006728 product (indole) binding pocket [chemical binding]; other site 698963006729 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 698963006730 active site 698963006731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 698963006732 pantoate--beta-alanine ligase; Region: panC; TIGR00018 698963006733 Pantoate-beta-alanine ligase; Region: PanC; cd00560 698963006734 active site 698963006735 ATP-binding site [chemical binding]; other site 698963006736 pantoate-binding site; other site 698963006737 HXXH motif; other site 698963006738 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 698963006739 oligomerization interface [polypeptide binding]; other site 698963006740 active site 698963006741 metal binding site [ion binding]; metal-binding site 698963006742 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698963006743 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698963006744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698963006745 catalytic residue [active] 698963006746 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 698963006747 substrate binding site [chemical binding]; other site 698963006748 active site 698963006749 catalytic residues [active] 698963006750 heterodimer interface [polypeptide binding]; other site 698963006751 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 698963006752 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698963006753 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 698963006754 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 698963006755 hypothetical protein; Validated; Region: PRK00228 698963006756 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 698963006757 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 698963006758 active site 698963006759 NTP binding site [chemical binding]; other site 698963006760 metal binding triad [ion binding]; metal-binding site 698963006761 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 698963006762 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698963006763 Zn2+ binding site [ion binding]; other site 698963006764 Mg2+ binding site [ion binding]; other site 698963006765 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 698963006766 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698963006767 active site 698963006768 Ap6A binding site [chemical binding]; other site 698963006769 nudix motif; other site 698963006770 metal binding site [ion binding]; metal-binding site 698963006771 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 698963006772 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 698963006773 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 698963006774 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698963006775 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698963006776 DNA binding residues [nucleotide binding] 698963006777 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 698963006778 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698963006779 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698963006780 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698963006781 catalytic residues [active] 698963006782 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698963006783 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698963006784 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 698963006785 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 698963006786 active site 698963006787 metal binding site [ion binding]; metal-binding site 698963006788 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 698963006789 ParB-like nuclease domain; Region: ParBc; pfam02195 698963006790 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698963006791 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698963006792 P-loop; other site 698963006793 Magnesium ion binding site [ion binding]; other site 698963006794 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698963006795 Magnesium ion binding site [ion binding]; other site 698963006796 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 698963006797 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 698963006798 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 698963006799 Haemolytic domain; Region: Haemolytic; pfam01809 698963006800 ribonuclease P; Reviewed; Region: rnpA; PRK03459 698963006801 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399