-- dump date 20140619_050838 -- class Genbank::misc_feature -- table misc_feature_note -- id note 698965000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 698965000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698965000003 Walker A motif; other site 698965000004 ATP binding site [chemical binding]; other site 698965000005 Walker B motif; other site 698965000006 arginine finger; other site 698965000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 698965000008 DnaA box-binding interface [nucleotide binding]; other site 698965000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 698965000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 698965000011 putative DNA binding surface [nucleotide binding]; other site 698965000012 dimer interface [polypeptide binding]; other site 698965000013 beta-clamp/clamp loader binding surface; other site 698965000014 beta-clamp/translesion DNA polymerase binding surface; other site 698965000015 recombination protein F; Reviewed; Region: recF; PRK00064 698965000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 698965000017 Walker A/P-loop; other site 698965000018 ATP binding site [chemical binding]; other site 698965000019 Q-loop/lid; other site 698965000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965000021 ABC transporter signature motif; other site 698965000022 Walker B; other site 698965000023 D-loop; other site 698965000024 H-loop/switch region; other site 698965000025 hypothetical protein; Provisional; Region: PRK00111 698965000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 698965000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698965000028 ATP binding site [chemical binding]; other site 698965000029 Mg2+ binding site [ion binding]; other site 698965000030 G-X-G motif; other site 698965000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698965000032 anchoring element; other site 698965000033 dimer interface [polypeptide binding]; other site 698965000034 ATP binding site [chemical binding]; other site 698965000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 698965000036 active site 698965000037 putative metal-binding site [ion binding]; other site 698965000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698965000039 DNA gyrase subunit A; Validated; Region: PRK05560 698965000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 698965000041 CAP-like domain; other site 698965000042 active site 698965000043 primary dimer interface [polypeptide binding]; other site 698965000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698965000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698965000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698965000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698965000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698965000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698965000050 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 698965000051 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698965000052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698965000053 DNA-binding site [nucleotide binding]; DNA binding site 698965000054 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698965000055 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698965000056 L-lactate permease; Region: Lactate_perm; cl00701 698965000057 Cadherin repeat-like domain; Region: CA_like; cl15786 698965000058 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698965000059 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698965000060 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 698965000061 Walker A/P-loop; other site 698965000062 ATP binding site [chemical binding]; other site 698965000063 Q-loop/lid; other site 698965000064 ABC transporter signature motif; other site 698965000065 Walker B; other site 698965000066 D-loop; other site 698965000067 H-loop/switch region; other site 698965000068 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698965000069 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698965000070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965000071 Walker A/P-loop; other site 698965000072 ATP binding site [chemical binding]; other site 698965000073 Q-loop/lid; other site 698965000074 ABC transporter signature motif; other site 698965000075 Walker B; other site 698965000076 D-loop; other site 698965000077 H-loop/switch region; other site 698965000078 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698965000079 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 698965000080 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698965000081 putative ligand binding site [chemical binding]; other site 698965000082 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698965000083 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698965000084 TM-ABC transporter signature motif; other site 698965000085 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698965000086 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698965000087 Walker A/P-loop; other site 698965000088 ATP binding site [chemical binding]; other site 698965000089 Q-loop/lid; other site 698965000090 ABC transporter signature motif; other site 698965000091 Walker B; other site 698965000092 D-loop; other site 698965000093 H-loop/switch region; other site 698965000094 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698965000095 active site 698965000096 Integrase core domain; Region: rve_2; pfam13333 698965000097 Rhomboid family; Region: Rhomboid; pfam01694 698965000098 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 698965000099 ThiC-associated domain; Region: ThiC-associated; pfam13667 698965000100 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 698965000101 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698965000102 thiamine phosphate binding site [chemical binding]; other site 698965000103 active site 698965000104 pyrophosphate binding site [ion binding]; other site 698965000105 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698965000106 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 698965000107 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 698965000108 ThiS interaction site; other site 698965000109 putative active site [active] 698965000110 tetramer interface [polypeptide binding]; other site 698965000111 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 698965000112 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698965000113 ATP binding site [chemical binding]; other site 698965000114 substrate interface [chemical binding]; other site 698965000115 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698965000116 active site residue [active] 698965000117 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 698965000118 dimer interface [polypeptide binding]; other site 698965000119 substrate binding site [chemical binding]; other site 698965000120 ATP binding site [chemical binding]; other site 698965000121 helicase Cas3; Provisional; Region: PRK09694 698965000122 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 698965000123 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698965000124 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 698965000125 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 698965000126 CT1975-like protein; Region: Cas_CT1975; pfam09344 698965000127 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 698965000128 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 698965000129 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 698965000130 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 698965000131 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 698965000132 putative septation inhibitor protein; Reviewed; Region: PRK00159 698965000133 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698965000134 Protein kinase domain; Region: Pkinase; pfam00069 698965000135 active site 698965000136 ATP binding site [chemical binding]; other site 698965000137 substrate binding site [chemical binding]; other site 698965000138 activation loop (A-loop); other site 698965000139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698965000140 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698965000141 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698965000142 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698965000143 PASTA domain; Region: PASTA; pfam03793 698965000144 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698965000145 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698965000146 active site 698965000147 ATP binding site [chemical binding]; other site 698965000148 substrate binding site [chemical binding]; other site 698965000149 activation loop (A-loop); other site 698965000150 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698965000151 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698965000152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698965000153 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 698965000154 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 698965000155 Protein phosphatase 2C; Region: PP2C; pfam00481 698965000156 active site 698965000157 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698965000158 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698965000159 phosphopeptide binding site; other site 698965000160 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 698965000161 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698965000162 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698965000163 phosphopeptide binding site; other site 698965000164 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698965000165 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698965000166 non-specific DNA binding site [nucleotide binding]; other site 698965000167 salt bridge; other site 698965000168 sequence-specific DNA binding site [nucleotide binding]; other site 698965000169 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 698965000170 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 698965000171 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 698965000172 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 698965000173 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 698965000174 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698965000175 Walker A/P-loop; other site 698965000176 ATP binding site [chemical binding]; other site 698965000177 Q-loop/lid; other site 698965000178 ABC transporter signature motif; other site 698965000179 Walker B; other site 698965000180 D-loop; other site 698965000181 H-loop/switch region; other site 698965000182 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698965000183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698965000184 active site 698965000185 phosphorylation site [posttranslational modification] 698965000186 intermolecular recognition site; other site 698965000187 dimerization interface [polypeptide binding]; other site 698965000188 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698965000189 DNA binding residues [nucleotide binding] 698965000190 dimerization interface [polypeptide binding]; other site 698965000191 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698965000192 Histidine kinase; Region: HisKA_3; pfam07730 698965000193 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698965000194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698965000195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698965000196 dimer interface [polypeptide binding]; other site 698965000197 conserved gate region; other site 698965000198 putative PBP binding loops; other site 698965000199 ABC-ATPase subunit interface; other site 698965000200 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698965000201 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 698965000202 Walker A/P-loop; other site 698965000203 ATP binding site [chemical binding]; other site 698965000204 Q-loop/lid; other site 698965000205 ABC transporter signature motif; other site 698965000206 Walker B; other site 698965000207 D-loop; other site 698965000208 H-loop/switch region; other site 698965000209 Anti-sigma-K factor rskA; Region: RskA; pfam10099 698965000210 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 698965000211 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698965000212 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698965000213 DNA binding residues [nucleotide binding] 698965000214 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698965000215 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698965000216 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 698965000217 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698965000218 catalytic residues [active] 698965000219 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 698965000220 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698965000221 DNA binding residues [nucleotide binding] 698965000222 dimer interface [polypeptide binding]; other site 698965000223 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 698965000224 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 698965000225 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 698965000226 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 698965000227 putative metal binding site [ion binding]; other site 698965000228 biotin synthase; Validated; Region: PRK06256 698965000229 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698965000230 FeS/SAM binding site; other site 698965000231 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698965000232 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 698965000233 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 698965000234 putative ligand binding residues [chemical binding]; other site 698965000235 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698965000236 ABC-ATPase subunit interface; other site 698965000237 dimer interface [polypeptide binding]; other site 698965000238 putative PBP binding regions; other site 698965000239 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698965000240 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698965000241 Walker A/P-loop; other site 698965000242 ATP binding site [chemical binding]; other site 698965000243 Q-loop/lid; other site 698965000244 ABC transporter signature motif; other site 698965000245 Walker B; other site 698965000246 D-loop; other site 698965000247 H-loop/switch region; other site 698965000248 Uncharacterized conserved protein [Function unknown]; Region: COG5646 698965000249 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 698965000250 DNA photolyase; Region: DNA_photolyase; pfam00875 698965000251 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 698965000252 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 698965000253 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 698965000254 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 698965000255 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 698965000256 Lipase (class 2); Region: Lipase_2; pfam01674 698965000257 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 698965000258 dimer interface [polypeptide binding]; other site 698965000259 FMN binding site [chemical binding]; other site 698965000260 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698965000261 Divergent AAA domain; Region: AAA_4; pfam04326 698965000262 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698965000263 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698965000264 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 698965000265 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 698965000266 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 698965000267 trimer interface [polypeptide binding]; other site 698965000268 putative metal binding site [ion binding]; other site 698965000269 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698965000270 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 698965000271 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 698965000272 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 698965000273 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698965000274 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698965000275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 698965000276 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698965000277 MarR family; Region: MarR; pfam01047 698965000278 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 698965000279 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698965000280 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698965000281 hypothetical protein; Provisional; Region: PRK10621 698965000282 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698965000283 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 698965000284 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698965000285 ATP binding site [chemical binding]; other site 698965000286 putative Mg++ binding site [ion binding]; other site 698965000287 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698965000288 nucleotide binding region [chemical binding]; other site 698965000289 Helicase associated domain (HA2); Region: HA2; pfam04408 698965000290 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 698965000291 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 698965000292 maltose O-acetyltransferase; Provisional; Region: PRK10092 698965000293 active site 698965000294 substrate binding site [chemical binding]; other site 698965000295 trimer interface [polypeptide binding]; other site 698965000296 CoA binding site [chemical binding]; other site 698965000297 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698965000298 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 698965000299 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698965000300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698965000301 NAD(P) binding site [chemical binding]; other site 698965000302 active site 698965000303 potential frameshift: common BLAST hit: gi|336325819|ref|YP_004605785.1| transposase for insertion sequence element 698965000304 potential frameshift: common BLAST hit: gi|336325819|ref|YP_004605785.1| transposase for insertion sequence element 698965000305 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698965000306 Integrase core domain; Region: rve; pfam00665 698965000307 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698965000308 Integrase core domain; Region: rve; pfam00665 698965000309 SdpI/YhfL protein family; Region: SdpI; pfam13630 698965000310 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698965000311 RNA binding surface [nucleotide binding]; other site 698965000312 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698965000313 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698965000314 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698965000315 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 698965000316 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 698965000317 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 698965000318 active site 698965000319 Zn binding site [ion binding]; other site 698965000320 Protease prsW family; Region: PrsW-protease; pfam13367 698965000321 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698965000322 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 698965000323 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 698965000324 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 698965000325 short chain dehydrogenase; Provisional; Region: PRK07904 698965000326 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698965000327 NAD(P) binding site [chemical binding]; other site 698965000328 active site 698965000329 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698965000330 FAD binding domain; Region: FAD_binding_4; pfam01565 698965000331 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 698965000332 Predicted membrane protein [Function unknown]; Region: COG2246 698965000333 GtrA-like protein; Region: GtrA; pfam04138 698965000334 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698965000335 putative active site [active] 698965000336 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698965000337 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698965000338 active site 698965000339 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698965000340 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698965000341 intersubunit interface [polypeptide binding]; other site 698965000342 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698965000343 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698965000344 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698965000345 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698965000346 ABC-ATPase subunit interface; other site 698965000347 dimer interface [polypeptide binding]; other site 698965000348 putative PBP binding regions; other site 698965000349 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698965000350 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698965000351 ABC-ATPase subunit interface; other site 698965000352 dimer interface [polypeptide binding]; other site 698965000353 putative PBP binding regions; other site 698965000354 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698965000355 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698965000356 intersubunit interface [polypeptide binding]; other site 698965000357 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 698965000358 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 698965000359 Walker A/P-loop; other site 698965000360 ATP binding site [chemical binding]; other site 698965000361 Q-loop/lid; other site 698965000362 ABC transporter signature motif; other site 698965000363 Walker B; other site 698965000364 D-loop; other site 698965000365 H-loop/switch region; other site 698965000366 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 698965000367 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698965000368 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698965000369 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698965000370 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698965000371 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 698965000372 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 698965000373 NAD(P) binding site [chemical binding]; other site 698965000374 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 698965000375 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698965000376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698965000377 homodimer interface [polypeptide binding]; other site 698965000378 catalytic residue [active] 698965000379 potential frameshift: common BLAST hit: gi|62389123|ref|YP_224525.1| Sodium:sulfate symporter transmembrane component 698965000380 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 698965000381 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 698965000382 transmembrane helices; other site 698965000383 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 698965000384 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 698965000385 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 698965000386 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 698965000387 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698965000388 active site 698965000389 catalytic residues [active] 698965000390 DNA binding site [nucleotide binding] 698965000391 Int/Topo IB signature motif; other site 698965000392 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698965000393 sequence-specific DNA binding site [nucleotide binding]; other site 698965000394 salt bridge; other site 698965000395 Domain of unknown function (DUF955); Region: DUF955; cl01076 698965000396 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698965000397 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698965000398 non-specific DNA binding site [nucleotide binding]; other site 698965000399 salt bridge; other site 698965000400 sequence-specific DNA binding site [nucleotide binding]; other site 698965000401 Prophage antirepressor [Transcription]; Region: COG3617 698965000402 BRO family, N-terminal domain; Region: Bro-N; smart01040 698965000403 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 698965000404 Helix-turn-helix domain; Region: HTH_17; pfam12728 698965000405 Phage Terminase; Region: Terminase_1; pfam03354 698965000406 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698965000407 Phage-related protein [Function unknown]; Region: COG4695; cl01923 698965000408 Phage portal protein; Region: Phage_portal; pfam04860 698965000409 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 698965000410 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 698965000411 Phage capsid family; Region: Phage_capsid; pfam05065 698965000412 Phage-related minor tail protein [Function unknown]; Region: COG5280 698965000413 MAEBL; Provisional; Region: PTZ00121 698965000414 potential frameshift: common BLAST hit: gi|337291538|ref|YP_004630559.1| immunity-specific protein beta371 698965000415 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698965000416 amidase catalytic site [active] 698965000417 Zn binding residues [ion binding]; other site 698965000418 substrate binding site [chemical binding]; other site 698965000419 ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; Region: ADP_ribosyl; cd01341 698965000420 nad+ binding pocket [chemical binding]; other site 698965000421 Diphtheria toxin, T domain; Region: Diphtheria_T; pfam02764 698965000422 Diphtheria toxin, R domain; Region: Diphtheria_R; pfam01324 698965000423 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698965000424 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 698965000425 NodB motif; other site 698965000426 active site 698965000427 catalytic site [active] 698965000428 metal binding site [ion binding]; metal-binding site 698965000429 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698965000430 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698965000431 DNA-binding site [nucleotide binding]; DNA binding site 698965000432 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698965000433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698965000434 homodimer interface [polypeptide binding]; other site 698965000435 catalytic residue [active] 698965000436 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 698965000437 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 698965000438 active site 698965000439 multimer interface [polypeptide binding]; other site 698965000440 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 698965000441 predicted active site [active] 698965000442 catalytic triad [active] 698965000443 potential frameshift: common BLAST hit: gi|68535552|ref|YP_250257.1| transposase IS3510c 698965000444 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698965000445 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698965000446 potential frameshift: common BLAST hit: gi|68535408|ref|YP_250113.1| transposase IS3510b 698965000447 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698965000448 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698965000449 active site 698965000450 catalytic site [active] 698965000451 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698965000452 active site 698965000453 catalytic site [active] 698965000454 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698965000455 metal ion-dependent adhesion site (MIDAS); other site 698965000456 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 698965000457 prephenate dehydrogenase; Validated; Region: PRK08507 698965000458 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 698965000459 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 698965000460 nucleoside/Zn binding site; other site 698965000461 dimer interface [polypeptide binding]; other site 698965000462 catalytic motif [active] 698965000463 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 698965000464 DNA binding residues [nucleotide binding] 698965000465 PIN domain; Region: PIN_3; pfam13470 698965000466 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 698965000467 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 698965000468 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 698965000469 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 698965000470 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 698965000471 active site 698965000472 HIGH motif; other site 698965000473 nucleotide binding site [chemical binding]; other site 698965000474 active site 698965000475 KMSKS motif; other site 698965000476 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 698965000477 fructuronate transporter; Provisional; Region: PRK10034; cl15264 698965000478 Shikimate kinase; Region: SKI; pfam01202 698965000479 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 698965000480 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 698965000481 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 698965000482 NADP binding site [chemical binding]; other site 698965000483 homodimer interface [polypeptide binding]; other site 698965000484 active site 698965000485 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 698965000486 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698965000487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698965000488 homodimer interface [polypeptide binding]; other site 698965000489 catalytic residue [active] 698965000490 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 698965000491 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 698965000492 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698965000493 Walker A motif; other site 698965000494 ATP binding site [chemical binding]; other site 698965000495 Walker B motif; other site 698965000496 arginine finger; other site 698965000497 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 698965000498 hypothetical protein; Validated; Region: PRK00153 698965000499 recombination protein RecR; Reviewed; Region: recR; PRK00076 698965000500 RecR protein; Region: RecR; pfam02132 698965000501 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 698965000502 putative active site [active] 698965000503 putative metal-binding site [ion binding]; other site 698965000504 tetramer interface [polypeptide binding]; other site 698965000505 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698965000506 catalytic triad [active] 698965000507 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 698965000508 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698965000509 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 698965000510 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 698965000511 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698965000512 active site 698965000513 catalytic site [active] 698965000514 substrate binding site [chemical binding]; other site 698965000515 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 698965000516 dimer interface [polypeptide binding]; other site 698965000517 FMN binding site [chemical binding]; other site 698965000518 NADPH bind site [chemical binding]; other site 698965000519 2-isopropylmalate synthase; Validated; Region: PRK03739 698965000520 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 698965000521 active site 698965000522 catalytic residues [active] 698965000523 metal binding site [ion binding]; metal-binding site 698965000524 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 698965000525 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698965000526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698965000527 DNA binding residues [nucleotide binding] 698965000528 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698965000529 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698965000530 active site 698965000531 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 698965000532 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698965000533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965000534 putative substrate translocation pore; other site 698965000535 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 698965000536 intersubunit interface [polypeptide binding]; other site 698965000537 active site 698965000538 catalytic residue [active] 698965000539 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 698965000540 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 698965000541 active site 698965000542 substrate binding site [chemical binding]; other site 698965000543 metal binding site [ion binding]; metal-binding site 698965000544 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 698965000545 aspartate kinase; Reviewed; Region: PRK06635 698965000546 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 698965000547 putative nucleotide binding site [chemical binding]; other site 698965000548 putative catalytic residues [active] 698965000549 putative Mg ion binding site [ion binding]; other site 698965000550 putative aspartate binding site [chemical binding]; other site 698965000551 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 698965000552 putative allosteric regulatory site; other site 698965000553 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 698965000554 putative allosteric regulatory residue; other site 698965000555 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 698965000556 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698965000557 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698965000558 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698965000559 DNA binding residues [nucleotide binding] 698965000560 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 698965000561 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 698965000562 heme binding pocket [chemical binding]; other site 698965000563 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698965000564 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 698965000565 Walker A/P-loop; other site 698965000566 ATP binding site [chemical binding]; other site 698965000567 Q-loop/lid; other site 698965000568 ABC transporter signature motif; other site 698965000569 Walker B; other site 698965000570 D-loop; other site 698965000571 H-loop/switch region; other site 698965000572 TOBE domain; Region: TOBE_2; pfam08402 698965000573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698965000574 dimer interface [polypeptide binding]; other site 698965000575 conserved gate region; other site 698965000576 ABC-ATPase subunit interface; other site 698965000577 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698965000578 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 698965000579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965000580 putative substrate translocation pore; other site 698965000581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965000582 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698965000583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698965000584 active site 698965000585 phosphorylation site [posttranslational modification] 698965000586 intermolecular recognition site; other site 698965000587 dimerization interface [polypeptide binding]; other site 698965000588 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698965000589 DNA binding site [nucleotide binding] 698965000590 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698965000591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698965000592 dimer interface [polypeptide binding]; other site 698965000593 phosphorylation site [posttranslational modification] 698965000594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698965000595 ATP binding site [chemical binding]; other site 698965000596 Mg2+ binding site [ion binding]; other site 698965000597 G-X-G motif; other site 698965000598 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 698965000599 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 698965000600 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 698965000601 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 698965000602 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698965000603 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 698965000604 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 698965000605 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698965000606 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 698965000607 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698965000608 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698965000609 Predicted membrane protein [Function unknown]; Region: COG1511 698965000610 Predicted membrane protein [Function unknown]; Region: COG1511 698965000611 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698965000612 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698965000613 putative active site [active] 698965000614 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 698965000615 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698965000616 putative active site [active] 698965000617 putative metal binding site [ion binding]; other site 698965000618 Yqey-like protein; Region: YqeY; pfam09424 698965000619 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698965000620 Transglycosylase; Region: Transgly; pfam00912 698965000621 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698965000622 PASTA domain; Region: PASTA; pfam03793 698965000623 Transcription factor WhiB; Region: Whib; pfam02467 698965000624 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 698965000625 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 698965000626 homotrimer interaction site [polypeptide binding]; other site 698965000627 putative active site [active] 698965000628 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698965000629 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698965000630 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698965000631 ligand binding site [chemical binding]; other site 698965000632 flexible hinge region; other site 698965000633 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698965000634 putative switch regulator; other site 698965000635 non-specific DNA interactions [nucleotide binding]; other site 698965000636 DNA binding site [nucleotide binding] 698965000637 sequence specific DNA binding site [nucleotide binding]; other site 698965000638 putative cAMP binding site [chemical binding]; other site 698965000639 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 698965000640 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698965000641 minor groove reading motif; other site 698965000642 helix-hairpin-helix signature motif; other site 698965000643 substrate binding pocket [chemical binding]; other site 698965000644 active site 698965000645 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 698965000646 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698965000647 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698965000648 catalytic residues [active] 698965000649 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 698965000650 putative active site [active] 698965000651 putative CoA binding site [chemical binding]; other site 698965000652 nudix motif; other site 698965000653 metal binding site [ion binding]; metal-binding site 698965000654 Colicin V production protein; Region: Colicin_V; pfam02674 698965000655 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 698965000656 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698965000657 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698965000658 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698965000659 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 698965000660 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698965000661 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698965000662 motif II; other site 698965000663 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 698965000664 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 698965000665 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 698965000666 ATP binding site [chemical binding]; other site 698965000667 Walker A motif; other site 698965000668 hexamer interface [polypeptide binding]; other site 698965000669 Walker B motif; other site 698965000670 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 698965000671 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 698965000672 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 698965000673 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 698965000674 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698965000675 ATP binding site [chemical binding]; other site 698965000676 putative Mg++ binding site [ion binding]; other site 698965000677 nucleotide binding region [chemical binding]; other site 698965000678 helicase superfamily c-terminal domain; Region: HELICc; smart00490 698965000679 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 698965000680 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698965000681 DNA-binding site [nucleotide binding]; DNA binding site 698965000682 RNA-binding motif; other site 698965000683 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698965000684 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698965000685 Walker A/P-loop; other site 698965000686 ATP binding site [chemical binding]; other site 698965000687 Q-loop/lid; other site 698965000688 ABC transporter signature motif; other site 698965000689 Walker B; other site 698965000690 D-loop; other site 698965000691 H-loop/switch region; other site 698965000692 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698965000693 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698965000694 Walker A/P-loop; other site 698965000695 ATP binding site [chemical binding]; other site 698965000696 Q-loop/lid; other site 698965000697 ABC transporter signature motif; other site 698965000698 Walker B; other site 698965000699 D-loop; other site 698965000700 H-loop/switch region; other site 698965000701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965000702 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698965000703 putative substrate translocation pore; other site 698965000704 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698965000705 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 698965000706 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698965000707 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 698965000708 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698965000709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698965000710 dimer interface [polypeptide binding]; other site 698965000711 conserved gate region; other site 698965000712 putative PBP binding loops; other site 698965000713 ABC-ATPase subunit interface; other site 698965000714 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698965000715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698965000716 NAD(P) binding site [chemical binding]; other site 698965000717 active site 698965000718 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 698965000719 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 698965000720 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 698965000721 active site 698965000722 interdomain interaction site; other site 698965000723 putative metal-binding site [ion binding]; other site 698965000724 nucleotide binding site [chemical binding]; other site 698965000725 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 698965000726 domain I; other site 698965000727 DNA binding groove [nucleotide binding] 698965000728 phosphate binding site [ion binding]; other site 698965000729 domain II; other site 698965000730 domain III; other site 698965000731 nucleotide binding site [chemical binding]; other site 698965000732 catalytic site [active] 698965000733 domain IV; other site 698965000734 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 698965000735 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698965000736 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698965000737 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698965000738 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698965000739 active site 698965000740 Predicted membrane protein [Function unknown]; Region: COG1297 698965000741 putative oligopeptide transporter, OPT family; Region: TIGR00733 698965000742 Laminin G domain; Region: Laminin_G_2; pfam02210 698965000743 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698965000744 catalytic site [active] 698965000745 Asp-box motif; other site 698965000746 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698965000747 dimerization interface [polypeptide binding]; other site 698965000748 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698965000749 cyclase homology domain; Region: CHD; cd07302 698965000750 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698965000751 dimer interface [polypeptide binding]; other site 698965000752 DNA polymerase III subunit delta'; Validated; Region: PRK07940 698965000753 DNA polymerase III subunit delta'; Validated; Region: PRK08485 698965000754 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 698965000755 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698965000756 active site 698965000757 catalytic residues [active] 698965000758 DNA binding site [nucleotide binding] 698965000759 Int/Topo IB signature motif; other site 698965000760 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 698965000761 Winged helix-turn helix; Region: HTH_29; pfam13551 698965000762 Helix-turn-helix domain; Region: HTH_28; pfam13518 698965000763 putative transposase OrfB; Reviewed; Region: PHA02517 698965000764 HTH-like domain; Region: HTH_21; pfam13276 698965000765 Integrase core domain; Region: rve; pfam00665 698965000766 Integrase core domain; Region: rve_2; pfam13333 698965000767 Homeodomain-like domain; Region: HTH_23; cl17451 698965000768 Helix-turn-helix domain; Region: HTH_38; pfam13936 698965000769 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698965000770 Integrase core domain; Region: rve; pfam00665 698965000771 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698965000772 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698965000773 Fic family protein [Function unknown]; Region: COG3177 698965000774 Fic/DOC family; Region: Fic; pfam02661 698965000775 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698965000776 Trypsin; Region: Trypsin; pfam00089 698965000777 active site 698965000778 potential frameshift: common BLAST hit: gi|296285263|ref|YP_003657305.1| transposase B 698965000779 Integrase core domain; Region: rve_3; cl15866 698965000780 putative transposase OrfB; Reviewed; Region: PHA02517 698965000781 HTH-like domain; Region: HTH_21; pfam13276 698965000782 acyl-CoA synthetase; Validated; Region: PRK07788 698965000783 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698965000784 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698965000785 acyl-activating enzyme (AAE) consensus motif; other site 698965000786 acyl-activating enzyme (AAE) consensus motif; other site 698965000787 AMP binding site [chemical binding]; other site 698965000788 active site 698965000789 CoA binding site [chemical binding]; other site 698965000790 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 698965000791 active site 698965000792 catalytic triad [active] 698965000793 oxyanion hole [active] 698965000794 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 698965000795 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 698965000796 substrate binding site; other site 698965000797 tetramer interface; other site 698965000798 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 698965000799 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 698965000800 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 698965000801 NADP binding site [chemical binding]; other site 698965000802 active site 698965000803 putative substrate binding site [chemical binding]; other site 698965000804 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 698965000805 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 698965000806 NAD binding site [chemical binding]; other site 698965000807 substrate binding site [chemical binding]; other site 698965000808 homodimer interface [polypeptide binding]; other site 698965000809 active site 698965000810 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 698965000811 Zn binding site [ion binding]; other site 698965000812 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 698965000813 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698965000814 Putative esterase; Region: Esterase; pfam00756 698965000815 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 698965000816 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 698965000817 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698965000818 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698965000819 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698965000820 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698965000821 non-specific DNA binding site [nucleotide binding]; other site 698965000822 salt bridge; other site 698965000823 sequence-specific DNA binding site [nucleotide binding]; other site 698965000824 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 698965000825 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698965000826 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 698965000827 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 698965000828 putative Iron-sulfur protein interface [polypeptide binding]; other site 698965000829 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 698965000830 proximal heme binding site [chemical binding]; other site 698965000831 distal heme binding site [chemical binding]; other site 698965000832 putative dimer interface [polypeptide binding]; other site 698965000833 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 698965000834 L-aspartate oxidase; Provisional; Region: PRK06175 698965000835 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 698965000836 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 698965000837 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 698965000838 Predicted membrane protein [Function unknown]; Region: COG2733 698965000839 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 698965000840 Class I aldolases; Region: Aldolase_Class_I; cd00945 698965000841 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698965000842 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 698965000843 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698965000844 FeS/SAM binding site; other site 698965000845 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 698965000846 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698965000847 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 698965000848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698965000849 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 698965000850 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 698965000851 FAD binding domain; Region: FAD_binding_4; pfam01565 698965000852 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 698965000853 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 698965000854 pentamer interface [polypeptide binding]; other site 698965000855 dodecaamer interface [polypeptide binding]; other site 698965000856 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698965000857 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698965000858 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698965000859 acyl-activating enzyme (AAE) consensus motif; other site 698965000860 AMP binding site [chemical binding]; other site 698965000861 active site 698965000862 CoA binding site [chemical binding]; other site 698965000863 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698965000864 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698965000865 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698965000866 acyl-activating enzyme (AAE) consensus motif; other site 698965000867 AMP binding site [chemical binding]; other site 698965000868 active site 698965000869 CoA binding site [chemical binding]; other site 698965000870 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 698965000871 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 698965000872 putative ADP-binding pocket [chemical binding]; other site 698965000873 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698965000874 catalytic core [active] 698965000875 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698965000876 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698965000877 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698965000878 dimer interface [polypeptide binding]; other site 698965000879 phosphorylation site [posttranslational modification] 698965000880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698965000881 ATP binding site [chemical binding]; other site 698965000882 Mg2+ binding site [ion binding]; other site 698965000883 G-X-G motif; other site 698965000884 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698965000885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698965000886 active site 698965000887 phosphorylation site [posttranslational modification] 698965000888 intermolecular recognition site; other site 698965000889 dimerization interface [polypeptide binding]; other site 698965000890 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698965000891 DNA binding site [nucleotide binding] 698965000892 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698965000893 DNA binding domain, excisionase family; Region: excise; TIGR01764 698965000894 Thioredoxin; Region: Thioredoxin_4; cl17273 698965000895 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698965000896 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698965000897 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 698965000898 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698965000899 motif II; other site 698965000900 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 698965000901 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 698965000902 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 698965000903 tRNA; other site 698965000904 putative tRNA binding site [nucleotide binding]; other site 698965000905 putative NADP binding site [chemical binding]; other site 698965000906 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 698965000907 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 698965000908 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 698965000909 domain interfaces; other site 698965000910 active site 698965000911 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 698965000912 active site 698965000913 homodimer interface [polypeptide binding]; other site 698965000914 SAM binding site [chemical binding]; other site 698965000915 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 698965000916 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 698965000917 active site 698965000918 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 698965000919 dimer interface [polypeptide binding]; other site 698965000920 active site 698965000921 Schiff base residues; other site 698965000922 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 698965000923 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698965000924 Predicted membrane protein [Function unknown]; Region: COG2311 698965000925 Protein of unknown function (DUF418); Region: DUF418; pfam04235 698965000926 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 698965000927 substrate binding site [chemical binding]; other site 698965000928 active site 698965000929 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 698965000930 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 698965000931 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698965000932 inhibitor-cofactor binding pocket; inhibition site 698965000933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698965000934 catalytic residue [active] 698965000935 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698965000936 catalytic core [active] 698965000937 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698965000938 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698965000939 catalytic residues [active] 698965000940 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698965000941 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698965000942 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 698965000943 ResB-like family; Region: ResB; pfam05140 698965000944 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 698965000945 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698965000946 dimerization interface [polypeptide binding]; other site 698965000947 putative DNA binding site [nucleotide binding]; other site 698965000948 putative Zn2+ binding site [ion binding]; other site 698965000949 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 698965000950 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 698965000951 UbiA prenyltransferase family; Region: UbiA; pfam01040 698965000952 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698965000953 active site 698965000954 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698965000955 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 698965000956 acyl-activating enzyme (AAE) consensus motif; other site 698965000957 AMP binding site [chemical binding]; other site 698965000958 active site 698965000959 CoA binding site [chemical binding]; other site 698965000960 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 698965000961 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698965000962 substrate binding site [chemical binding]; other site 698965000963 oxyanion hole (OAH) forming residues; other site 698965000964 trimer interface [polypeptide binding]; other site 698965000965 O-succinylbenzoate synthase; Provisional; Region: PRK02901 698965000966 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 698965000967 active site 698965000968 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 698965000969 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 698965000970 dimer interface [polypeptide binding]; other site 698965000971 tetramer interface [polypeptide binding]; other site 698965000972 PYR/PP interface [polypeptide binding]; other site 698965000973 TPP binding site [chemical binding]; other site 698965000974 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 698965000975 TPP-binding site; other site 698965000976 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698965000977 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 698965000978 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 698965000979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698965000980 S-adenosylmethionine binding site [chemical binding]; other site 698965000981 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 698965000982 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 698965000983 NAD binding site [chemical binding]; other site 698965000984 dimer interface [polypeptide binding]; other site 698965000985 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698965000986 substrate binding site [chemical binding]; other site 698965000987 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 698965000988 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698965000989 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698965000990 substrate binding pocket [chemical binding]; other site 698965000991 chain length determination region; other site 698965000992 substrate-Mg2+ binding site; other site 698965000993 catalytic residues [active] 698965000994 aspartate-rich region 1; other site 698965000995 active site lid residues [active] 698965000996 aspartate-rich region 2; other site 698965000997 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 698965000998 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 698965000999 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 698965001000 putative homodimer interface [polypeptide binding]; other site 698965001001 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 698965001002 heterodimer interface [polypeptide binding]; other site 698965001003 homodimer interface [polypeptide binding]; other site 698965001004 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 698965001005 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 698965001006 23S rRNA interface [nucleotide binding]; other site 698965001007 L7/L12 interface [polypeptide binding]; other site 698965001008 putative thiostrepton binding site; other site 698965001009 L25 interface [polypeptide binding]; other site 698965001010 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 698965001011 mRNA/rRNA interface [nucleotide binding]; other site 698965001012 Homeodomain-like domain; Region: HTH_23; cl17451 698965001013 Helix-turn-helix domain; Region: HTH_28; pfam13518 698965001014 putative transposase OrfB; Reviewed; Region: PHA02517 698965001015 HTH-like domain; Region: HTH_21; pfam13276 698965001016 Integrase core domain; Region: rve; pfam00665 698965001017 Integrase core domain; Region: rve_2; pfam13333 698965001018 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 698965001019 23S rRNA interface [nucleotide binding]; other site 698965001020 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 698965001021 50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157 698965001022 L11 interface [polypeptide binding]; other site 698965001023 putative EF-Tu interaction site [polypeptide binding]; other site 698965001024 putative EF-G interaction site [polypeptide binding]; other site 698965001025 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 698965001026 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698965001027 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698965001028 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698965001029 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698965001030 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698965001031 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 698965001032 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698965001033 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698965001034 ABC-ATPase subunit interface; other site 698965001035 dimer interface [polypeptide binding]; other site 698965001036 putative PBP binding regions; other site 698965001037 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698965001038 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698965001039 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698965001040 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698965001041 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 698965001042 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 698965001043 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 698965001044 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 698965001045 RPB1 interaction site [polypeptide binding]; other site 698965001046 RPB10 interaction site [polypeptide binding]; other site 698965001047 RPB11 interaction site [polypeptide binding]; other site 698965001048 RPB3 interaction site [polypeptide binding]; other site 698965001049 RPB12 interaction site [polypeptide binding]; other site 698965001050 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 698965001051 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 698965001052 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 698965001053 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 698965001054 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 698965001055 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698965001056 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 698965001057 G-loop; other site 698965001058 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698965001059 DNA binding site [nucleotide binding] 698965001060 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 698965001061 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 698965001062 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 698965001063 HTH-like domain; Region: HTH_21; pfam13276 698965001064 Integrase core domain; Region: rve; pfam00665 698965001065 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698965001066 Histidine kinase; Region: HisKA_3; pfam07730 698965001067 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698965001068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698965001069 active site 698965001070 phosphorylation site [posttranslational modification] 698965001071 intermolecular recognition site; other site 698965001072 dimerization interface [polypeptide binding]; other site 698965001073 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698965001074 DNA binding residues [nucleotide binding] 698965001075 dimerization interface [polypeptide binding]; other site 698965001076 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698965001077 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698965001078 Walker A/P-loop; other site 698965001079 ATP binding site [chemical binding]; other site 698965001080 Q-loop/lid; other site 698965001081 ABC transporter signature motif; other site 698965001082 Walker B; other site 698965001083 D-loop; other site 698965001084 H-loop/switch region; other site 698965001085 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 698965001086 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 698965001087 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698965001088 TIGR03943 family protein; Region: TIGR03943 698965001089 Predicted permeases [General function prediction only]; Region: COG0701 698965001090 Radical SAM superfamily; Region: Radical_SAM; pfam04055 698965001091 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698965001092 FeS/SAM binding site; other site 698965001093 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 698965001094 Class III ribonucleotide reductase; Region: RNR_III; cd01675 698965001095 effector binding site; other site 698965001096 active site 698965001097 Zn binding site [ion binding]; other site 698965001098 glycine loop; other site 698965001099 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 698965001100 S17 interaction site [polypeptide binding]; other site 698965001101 S8 interaction site; other site 698965001102 16S rRNA interaction site [nucleotide binding]; other site 698965001103 streptomycin interaction site [chemical binding]; other site 698965001104 23S rRNA interaction site [nucleotide binding]; other site 698965001105 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 698965001106 30S ribosomal protein S7; Validated; Region: PRK05302 698965001107 elongation factor G; Reviewed; Region: PRK00007 698965001108 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 698965001109 G1 box; other site 698965001110 putative GEF interaction site [polypeptide binding]; other site 698965001111 GTP/Mg2+ binding site [chemical binding]; other site 698965001112 Switch I region; other site 698965001113 G2 box; other site 698965001114 G3 box; other site 698965001115 Switch II region; other site 698965001116 G4 box; other site 698965001117 G5 box; other site 698965001118 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 698965001119 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 698965001120 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 698965001121 elongation factor Tu; Reviewed; Region: PRK00049 698965001122 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 698965001123 G1 box; other site 698965001124 GEF interaction site [polypeptide binding]; other site 698965001125 GTP/Mg2+ binding site [chemical binding]; other site 698965001126 Switch I region; other site 698965001127 G2 box; other site 698965001128 G3 box; other site 698965001129 Switch II region; other site 698965001130 G4 box; other site 698965001131 G5 box; other site 698965001132 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 698965001133 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 698965001134 Antibiotic Binding Site [chemical binding]; other site 698965001135 Predicted membrane protein [Function unknown]; Region: COG2323 698965001136 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 698965001137 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 698965001138 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 698965001139 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 698965001140 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 698965001141 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 698965001142 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 698965001143 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 698965001144 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 698965001145 putative translocon binding site; other site 698965001146 protein-rRNA interface [nucleotide binding]; other site 698965001147 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 698965001148 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 698965001149 G-X-X-G motif; other site 698965001150 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 698965001151 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 698965001152 23S rRNA interface [nucleotide binding]; other site 698965001153 5S rRNA interface [nucleotide binding]; other site 698965001154 putative antibiotic binding site [chemical binding]; other site 698965001155 L25 interface [polypeptide binding]; other site 698965001156 L27 interface [polypeptide binding]; other site 698965001157 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 698965001158 putative translocon interaction site; other site 698965001159 23S rRNA interface [nucleotide binding]; other site 698965001160 signal recognition particle (SRP54) interaction site; other site 698965001161 L23 interface [polypeptide binding]; other site 698965001162 trigger factor interaction site; other site 698965001163 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 698965001164 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698965001165 HlyD family secretion protein; Region: HlyD_3; pfam13437 698965001166 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698965001167 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698965001168 Walker A/P-loop; other site 698965001169 ATP binding site [chemical binding]; other site 698965001170 Q-loop/lid; other site 698965001171 ABC transporter signature motif; other site 698965001172 Walker B; other site 698965001173 D-loop; other site 698965001174 H-loop/switch region; other site 698965001175 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698965001176 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698965001177 FtsX-like permease family; Region: FtsX; pfam02687 698965001178 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 698965001179 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 698965001180 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 698965001181 RNA binding site [nucleotide binding]; other site 698965001182 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 698965001183 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 698965001184 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 698965001185 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 698965001186 serine transporter; Region: stp; TIGR00814 698965001187 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698965001188 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698965001189 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698965001190 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698965001191 active site 698965001192 homotetramer interface [polypeptide binding]; other site 698965001193 homodimer interface [polypeptide binding]; other site 698965001194 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 698965001195 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698965001196 ATP binding site [chemical binding]; other site 698965001197 substrate interface [chemical binding]; other site 698965001198 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698965001199 active site residue [active] 698965001200 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698965001201 MPT binding site; other site 698965001202 trimer interface [polypeptide binding]; other site 698965001203 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 698965001204 MoaE homodimer interface [polypeptide binding]; other site 698965001205 MoaD interaction [polypeptide binding]; other site 698965001206 active site residues [active] 698965001207 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 698965001208 MoaE interaction surface [polypeptide binding]; other site 698965001209 MoeB interaction surface [polypeptide binding]; other site 698965001210 thiocarboxylated glycine; other site 698965001211 Predicted transcriptional regulator [Transcription]; Region: COG2345 698965001212 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 698965001213 DNA binding residues [nucleotide binding] 698965001214 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698965001215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698965001216 dimer interface [polypeptide binding]; other site 698965001217 conserved gate region; other site 698965001218 putative PBP binding loops; other site 698965001219 ABC-ATPase subunit interface; other site 698965001220 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965001221 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 698965001222 Walker A/P-loop; other site 698965001223 ATP binding site [chemical binding]; other site 698965001224 Q-loop/lid; other site 698965001225 ABC transporter signature motif; other site 698965001226 Walker B; other site 698965001227 D-loop; other site 698965001228 H-loop/switch region; other site 698965001229 TOBE domain; Region: TOBE; cl01440 698965001230 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 698965001231 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698965001232 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 698965001233 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 698965001234 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 698965001235 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 698965001236 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 698965001237 [4Fe-4S] binding site [ion binding]; other site 698965001238 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698965001239 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698965001240 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698965001241 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 698965001242 molybdopterin cofactor binding site; other site 698965001243 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 698965001244 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 698965001245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965001246 putative substrate translocation pore; other site 698965001247 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698965001248 MPT binding site; other site 698965001249 trimer interface [polypeptide binding]; other site 698965001250 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 698965001251 GTP binding site; other site 698965001252 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 698965001253 trimer interface [polypeptide binding]; other site 698965001254 dimer interface [polypeptide binding]; other site 698965001255 putative active site [active] 698965001256 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698965001257 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698965001258 dimer interface [polypeptide binding]; other site 698965001259 putative functional site; other site 698965001260 putative MPT binding site; other site 698965001261 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 698965001262 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698965001263 FeS/SAM binding site; other site 698965001264 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 698965001265 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698965001266 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698965001267 inhibitor site; inhibition site 698965001268 active site 698965001269 dimer interface [polypeptide binding]; other site 698965001270 catalytic residue [active] 698965001271 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698965001272 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698965001273 Walker A/P-loop; other site 698965001274 ATP binding site [chemical binding]; other site 698965001275 Q-loop/lid; other site 698965001276 ABC transporter signature motif; other site 698965001277 Walker B; other site 698965001278 D-loop; other site 698965001279 H-loop/switch region; other site 698965001280 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698965001281 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698965001282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698965001283 dimer interface [polypeptide binding]; other site 698965001284 conserved gate region; other site 698965001285 putative PBP binding loops; other site 698965001286 ABC-ATPase subunit interface; other site 698965001287 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698965001288 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698965001289 Walker A/P-loop; other site 698965001290 ATP binding site [chemical binding]; other site 698965001291 Q-loop/lid; other site 698965001292 ABC transporter signature motif; other site 698965001293 Walker B; other site 698965001294 D-loop; other site 698965001295 H-loop/switch region; other site 698965001296 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698965001297 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698965001298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698965001299 dimer interface [polypeptide binding]; other site 698965001300 conserved gate region; other site 698965001301 putative PBP binding loops; other site 698965001302 ABC-ATPase subunit interface; other site 698965001303 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 698965001304 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698965001305 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698965001306 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698965001307 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698965001308 DNA-binding site [nucleotide binding]; DNA binding site 698965001309 FCD domain; Region: FCD; pfam07729 698965001310 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698965001311 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698965001312 nucleotide binding site [chemical binding]; other site 698965001313 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 698965001314 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 698965001315 putative active site cavity [active] 698965001316 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 698965001317 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 698965001318 active site 698965001319 dimer interface [polypeptide binding]; other site 698965001320 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698965001321 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 698965001322 active site 698965001323 trimer interface [polypeptide binding]; other site 698965001324 allosteric site; other site 698965001325 active site lid [active] 698965001326 hexamer (dimer of trimers) interface [polypeptide binding]; other site 698965001327 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 698965001328 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 698965001329 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698965001330 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698965001331 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 698965001332 5S rRNA interface [nucleotide binding]; other site 698965001333 L27 interface [polypeptide binding]; other site 698965001334 23S rRNA interface [nucleotide binding]; other site 698965001335 L5 interface [polypeptide binding]; other site 698965001336 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 698965001337 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 698965001338 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 698965001339 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 698965001340 23S rRNA binding site [nucleotide binding]; other site 698965001341 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 698965001342 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 698965001343 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 698965001344 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 698965001345 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698965001346 active site 698965001347 catalytic site [active] 698965001348 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698965001349 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698965001350 active site 698965001351 catalytic site [active] 698965001352 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 698965001353 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698965001354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698965001355 dimer interface [polypeptide binding]; other site 698965001356 conserved gate region; other site 698965001357 putative PBP binding loops; other site 698965001358 ABC-ATPase subunit interface; other site 698965001359 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698965001360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698965001361 dimer interface [polypeptide binding]; other site 698965001362 conserved gate region; other site 698965001363 putative PBP binding loops; other site 698965001364 ABC-ATPase subunit interface; other site 698965001365 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 698965001366 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698965001367 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698965001368 Walker A/P-loop; other site 698965001369 ATP binding site [chemical binding]; other site 698965001370 Q-loop/lid; other site 698965001371 ABC transporter signature motif; other site 698965001372 Walker B; other site 698965001373 D-loop; other site 698965001374 H-loop/switch region; other site 698965001375 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 698965001376 SecY translocase; Region: SecY; pfam00344 698965001377 adenylate kinase; Reviewed; Region: adk; PRK00279 698965001378 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 698965001379 AMP-binding site [chemical binding]; other site 698965001380 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 698965001381 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698965001382 active site 698965001383 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698965001384 catalytic site [active] 698965001385 BNR repeat-like domain; Region: BNR_2; pfam13088 698965001386 Asp-box motif; other site 698965001387 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698965001388 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 698965001389 rRNA binding site [nucleotide binding]; other site 698965001390 predicted 30S ribosome binding site; other site 698965001391 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 698965001392 30S ribosomal protein S13; Region: bact_S13; TIGR03631 698965001393 30S ribosomal protein S11; Validated; Region: PRK05309 698965001394 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 698965001395 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 698965001396 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698965001397 RNA binding surface [nucleotide binding]; other site 698965001398 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 698965001399 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 698965001400 alphaNTD - beta interaction site [polypeptide binding]; other site 698965001401 alphaNTD homodimer interface [polypeptide binding]; other site 698965001402 alphaNTD - beta' interaction site [polypeptide binding]; other site 698965001403 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 698965001404 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 698965001405 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 698965001406 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 698965001407 dimerization interface 3.5A [polypeptide binding]; other site 698965001408 active site 698965001409 Protein of unknown function (DUF690); Region: DUF690; cl04939 698965001410 TIGR02611 family protein; Region: TIGR02611 698965001411 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 698965001412 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 698965001413 active site 698965001414 catalytic residues [active] 698965001415 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 698965001416 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 698965001417 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698965001418 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 698965001419 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698965001420 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698965001421 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 698965001422 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 698965001423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 698965001424 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 698965001425 23S rRNA interface [nucleotide binding]; other site 698965001426 L3 interface [polypeptide binding]; other site 698965001427 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 698965001428 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 698965001429 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 698965001430 active site 698965001431 substrate binding site [chemical binding]; other site 698965001432 metal binding site [ion binding]; metal-binding site 698965001433 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 698965001434 alanine racemase; Reviewed; Region: alr; PRK00053 698965001435 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 698965001436 active site 698965001437 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698965001438 dimer interface [polypeptide binding]; other site 698965001439 substrate binding site [chemical binding]; other site 698965001440 catalytic residues [active] 698965001441 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 698965001442 Predicted permease [General function prediction only]; Region: COG2985 698965001443 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698965001444 TrkA-C domain; Region: TrkA_C; pfam02080 698965001445 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698965001446 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698965001447 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 698965001448 Glycoprotease family; Region: Peptidase_M22; pfam00814 698965001449 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698965001450 Coenzyme A binding pocket [chemical binding]; other site 698965001451 UGMP family protein; Validated; Region: PRK09604 698965001452 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 698965001453 oligomerisation interface [polypeptide binding]; other site 698965001454 mobile loop; other site 698965001455 roof hairpin; other site 698965001456 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698965001457 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698965001458 ring oligomerisation interface [polypeptide binding]; other site 698965001459 ATP/Mg binding site [chemical binding]; other site 698965001460 stacking interactions; other site 698965001461 hinge regions; other site 698965001462 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 698965001463 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698965001464 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698965001465 DNA binding residues [nucleotide binding] 698965001466 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 698965001467 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698965001468 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 698965001469 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 698965001470 active site 698965001471 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 698965001472 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698965001473 phosphate binding site [ion binding]; other site 698965001474 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698965001475 siderophore binding site; other site 698965001476 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698965001477 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698965001478 dimer interface [polypeptide binding]; other site 698965001479 putative PBP binding regions; other site 698965001480 ABC-ATPase subunit interface; other site 698965001481 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698965001482 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698965001483 ABC-ATPase subunit interface; other site 698965001484 dimer interface [polypeptide binding]; other site 698965001485 putative PBP binding regions; other site 698965001486 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698965001487 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698965001488 Walker A/P-loop; other site 698965001489 ATP binding site [chemical binding]; other site 698965001490 Q-loop/lid; other site 698965001491 ABC transporter signature motif; other site 698965001492 Walker B; other site 698965001493 D-loop; other site 698965001494 H-loop/switch region; other site 698965001495 IucA / IucC family; Region: IucA_IucC; pfam04183 698965001496 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698965001497 IucA / IucC family; Region: IucA_IucC; pfam04183 698965001498 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698965001499 H+ Antiporter protein; Region: 2A0121; TIGR00900 698965001500 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 698965001501 EamA-like transporter family; Region: EamA; pfam00892 698965001502 GMP synthase; Reviewed; Region: guaA; PRK00074 698965001503 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 698965001504 AMP/PPi binding site [chemical binding]; other site 698965001505 candidate oxyanion hole; other site 698965001506 catalytic triad [active] 698965001507 potential glutamine specificity residues [chemical binding]; other site 698965001508 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 698965001509 ATP Binding subdomain [chemical binding]; other site 698965001510 Ligand Binding sites [chemical binding]; other site 698965001511 Dimerization subdomain; other site 698965001512 PspC domain; Region: PspC; pfam04024 698965001513 PspC domain; Region: PspC; pfam04024 698965001514 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698965001515 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698965001516 ATP binding site [chemical binding]; other site 698965001517 Mg2+ binding site [ion binding]; other site 698965001518 G-X-G motif; other site 698965001519 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698965001520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698965001521 active site 698965001522 phosphorylation site [posttranslational modification] 698965001523 intermolecular recognition site; other site 698965001524 dimerization interface [polypeptide binding]; other site 698965001525 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698965001526 DNA binding residues [nucleotide binding] 698965001527 dimerization interface [polypeptide binding]; other site 698965001528 potential frameshift: common BLAST hit: gi|38233680|ref|NP_939447.1| iron transport system exported solute-binding component 698965001529 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698965001530 intersubunit interface [polypeptide binding]; other site 698965001531 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698965001532 DNA Polymerase Y-family; Region: PolY_like; cd03468 698965001533 active site 698965001534 DNA binding site [nucleotide binding] 698965001535 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 698965001536 putative dimer interface [polypeptide binding]; other site 698965001537 putative [2Fe-2S] cluster binding site [ion binding]; other site 698965001538 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698965001539 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698965001540 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698965001541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698965001542 dimer interface [polypeptide binding]; other site 698965001543 conserved gate region; other site 698965001544 ABC-ATPase subunit interface; other site 698965001545 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 698965001546 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 698965001547 Walker A/P-loop; other site 698965001548 ATP binding site [chemical binding]; other site 698965001549 Q-loop/lid; other site 698965001550 ABC transporter signature motif; other site 698965001551 Walker B; other site 698965001552 D-loop; other site 698965001553 H-loop/switch region; other site 698965001554 NIL domain; Region: NIL; cl09633 698965001555 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698965001556 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 698965001557 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698965001558 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 698965001559 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 698965001560 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 698965001561 active site 698965001562 PHP Thumb interface [polypeptide binding]; other site 698965001563 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698965001564 generic binding surface II; other site 698965001565 generic binding surface I; other site 698965001566 Uncharacterized conserved protein [Function unknown]; Region: COG3402 698965001567 Predicted membrane protein [Function unknown]; Region: COG3428 698965001568 Bacterial PH domain; Region: DUF304; pfam03703 698965001569 Bacterial PH domain; Region: DUF304; pfam03703 698965001570 Bacterial PH domain; Region: DUF304; pfam03703 698965001571 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698965001572 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698965001573 intersubunit interface [polypeptide binding]; other site 698965001574 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698965001575 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698965001576 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698965001577 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698965001578 dimer interface [polypeptide binding]; other site 698965001579 putative PBP binding regions; other site 698965001580 ABC-ATPase subunit interface; other site 698965001581 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698965001582 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698965001583 ABC-ATPase subunit interface; other site 698965001584 dimer interface [polypeptide binding]; other site 698965001585 putative PBP binding regions; other site 698965001586 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698965001587 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698965001588 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698965001589 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 698965001590 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 698965001591 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 698965001592 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 698965001593 homodimer interface [polypeptide binding]; other site 698965001594 NADP binding site [chemical binding]; other site 698965001595 substrate binding site [chemical binding]; other site 698965001596 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 698965001597 putative transposase OrfB; Reviewed; Region: PHA02517 698965001598 HTH-like domain; Region: HTH_21; pfam13276 698965001599 Integrase core domain; Region: rve; pfam00665 698965001600 Integrase core domain; Region: rve_2; pfam13333 698965001601 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698965001602 active site 698965001603 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 698965001604 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 698965001605 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698965001606 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698965001607 intersubunit interface [polypeptide binding]; other site 698965001608 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698965001609 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698965001610 ABC-ATPase subunit interface; other site 698965001611 dimer interface [polypeptide binding]; other site 698965001612 putative PBP binding regions; other site 698965001613 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 698965001614 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698965001615 Walker A/P-loop; other site 698965001616 ATP binding site [chemical binding]; other site 698965001617 Q-loop/lid; other site 698965001618 ABC transporter signature motif; other site 698965001619 Walker B; other site 698965001620 D-loop; other site 698965001621 H-loop/switch region; other site 698965001622 Htaa; Region: HtaA; pfam04213 698965001623 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 698965001624 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698965001625 homodimer interface [polypeptide binding]; other site 698965001626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698965001627 substrate-cofactor binding pocket; other site 698965001628 catalytic residue [active] 698965001629 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 698965001630 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 698965001631 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698965001632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965001633 putative substrate translocation pore; other site 698965001634 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698965001635 putative catalytic site [active] 698965001636 putative metal binding site [ion binding]; other site 698965001637 putative phosphate binding site [ion binding]; other site 698965001638 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 698965001639 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 698965001640 active site 698965001641 HIGH motif; other site 698965001642 dimer interface [polypeptide binding]; other site 698965001643 KMSKS motif; other site 698965001644 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 698965001645 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698965001646 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698965001647 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698965001648 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698965001649 NlpC/P60 family; Region: NLPC_P60; pfam00877 698965001650 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698965001651 active site 698965001652 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698965001653 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698965001654 non-specific DNA binding site [nucleotide binding]; other site 698965001655 salt bridge; other site 698965001656 sequence-specific DNA binding site [nucleotide binding]; other site 698965001657 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698965001658 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 698965001659 metal binding site [ion binding]; metal-binding site 698965001660 putative dimer interface [polypeptide binding]; other site 698965001661 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 698965001662 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698965001663 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698965001664 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698965001665 pyruvate carboxylase; Reviewed; Region: PRK12999 698965001666 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698965001667 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698965001668 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698965001669 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698965001670 active site 698965001671 catalytic residues [active] 698965001672 metal binding site [ion binding]; metal-binding site 698965001673 homodimer binding site [polypeptide binding]; other site 698965001674 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698965001675 carboxyltransferase (CT) interaction site; other site 698965001676 biotinylation site [posttranslational modification]; other site 698965001677 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 698965001678 ADP-ribose binding site [chemical binding]; other site 698965001679 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 698965001680 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698965001681 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 698965001682 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698965001683 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698965001684 carboxyltransferase (CT) interaction site; other site 698965001685 biotinylation site [posttranslational modification]; other site 698965001686 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698965001687 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698965001688 active site residue [active] 698965001689 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698965001690 active site residue [active] 698965001691 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698965001692 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 698965001693 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 698965001694 active site 698965001695 dimer interface [polypeptide binding]; other site 698965001696 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 698965001697 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698965001698 substrate binding site [chemical binding]; other site 698965001699 dimer interface [polypeptide binding]; other site 698965001700 ATP binding site [chemical binding]; other site 698965001701 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698965001702 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698965001703 DNA binding site [nucleotide binding] 698965001704 domain linker motif; other site 698965001705 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 698965001706 dimerization interface [polypeptide binding]; other site 698965001707 putative ligand binding site [chemical binding]; other site 698965001708 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 698965001709 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698965001710 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698965001711 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698965001712 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698965001713 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698965001714 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698965001715 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 698965001716 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 698965001717 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 698965001718 ATP-grasp domain; Region: ATP-grasp; pfam02222 698965001719 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 698965001720 Uncharacterized conserved protein [Function unknown]; Region: COG1434 698965001721 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698965001722 putative active site [active] 698965001723 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 698965001724 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 698965001725 HupF/HypC family; Region: HupF_HypC; pfam01455 698965001726 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 698965001727 dimerization interface [polypeptide binding]; other site 698965001728 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 698965001729 ATP binding site [chemical binding]; other site 698965001730 Acylphosphatase; Region: Acylphosphatase; pfam00708 698965001731 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 698965001732 HypF finger; Region: zf-HYPF; pfam07503 698965001733 HypF finger; Region: zf-HYPF; pfam07503 698965001734 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 698965001735 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 698965001736 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 698965001737 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698965001738 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 698965001739 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 698965001740 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 698965001741 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 698965001742 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 698965001743 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 698965001744 putative substrate-binding site; other site 698965001745 nickel binding site [ion binding]; other site 698965001746 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 698965001747 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 698965001748 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 698965001749 HupF/HypC family; Region: HupF_HypC; pfam01455 698965001750 TIGR03089 family protein; Region: TIGR03089 698965001751 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698965001752 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698965001753 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698965001754 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698965001755 active site 698965001756 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698965001757 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 698965001758 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 698965001759 active site 698965001760 Substrate binding site; other site 698965001761 Mg++ binding site; other site 698965001762 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698965001763 putative trimer interface [polypeptide binding]; other site 698965001764 putative CoA binding site [chemical binding]; other site 698965001765 Transcription factor WhiB; Region: Whib; pfam02467 698965001766 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 698965001767 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 698965001768 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 698965001769 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 698965001770 active site 698965001771 substrate binding site [chemical binding]; other site 698965001772 metal binding site [ion binding]; metal-binding site 698965001773 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 698965001774 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698965001775 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698965001776 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 698965001777 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 698965001778 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 698965001779 homotetramer interface [polypeptide binding]; other site 698965001780 ligand binding site [chemical binding]; other site 698965001781 catalytic site [active] 698965001782 NAD binding site [chemical binding]; other site 698965001783 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 698965001784 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 698965001785 TMP-binding site; other site 698965001786 ATP-binding site [chemical binding]; other site 698965001787 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698965001788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698965001789 active site 698965001790 phosphorylation site [posttranslational modification] 698965001791 intermolecular recognition site; other site 698965001792 dimerization interface [polypeptide binding]; other site 698965001793 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698965001794 DNA binding site [nucleotide binding] 698965001795 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698965001796 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698965001797 dimerization interface [polypeptide binding]; other site 698965001798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698965001799 dimer interface [polypeptide binding]; other site 698965001800 phosphorylation site [posttranslational modification] 698965001801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698965001802 ATP binding site [chemical binding]; other site 698965001803 Mg2+ binding site [ion binding]; other site 698965001804 G-X-G motif; other site 698965001805 lipoprotein LpqB; Provisional; Region: PRK13616 698965001806 Sporulation and spore germination; Region: Germane; pfam10646 698965001807 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 698965001808 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698965001809 active site 698965001810 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 698965001811 30S subunit binding site; other site 698965001812 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 698965001813 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698965001814 ATP binding site [chemical binding]; other site 698965001815 putative Mg++ binding site [ion binding]; other site 698965001816 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 698965001817 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698965001818 nucleotide binding region [chemical binding]; other site 698965001819 ATP-binding site [chemical binding]; other site 698965001820 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 698965001821 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 698965001822 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698965001823 FAD binding pocket [chemical binding]; other site 698965001824 FAD binding motif [chemical binding]; other site 698965001825 phosphate binding motif [ion binding]; other site 698965001826 beta-alpha-beta structure motif; other site 698965001827 NAD binding pocket [chemical binding]; other site 698965001828 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698965001829 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 698965001830 catalytic loop [active] 698965001831 iron binding site [ion binding]; other site 698965001832 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 698965001833 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 698965001834 putative di-iron ligands [ion binding]; other site 698965001835 Predicted GTPases [General function prediction only]; Region: COG1162 698965001836 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 698965001837 GTPase/Zn-binding domain interface [polypeptide binding]; other site 698965001838 GTP/Mg2+ binding site [chemical binding]; other site 698965001839 G4 box; other site 698965001840 G5 box; other site 698965001841 G1 box; other site 698965001842 Switch I region; other site 698965001843 G2 box; other site 698965001844 G3 box; other site 698965001845 Switch II region; other site 698965001846 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 698965001847 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 698965001848 hinge; other site 698965001849 active site 698965001850 Uncharacterized conserved protein [Function unknown]; Region: COG2135 698965001851 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 698965001852 putative deacylase active site [active] 698965001853 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 698965001854 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698965001855 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698965001856 DNA binding residues [nucleotide binding] 698965001857 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 698965001858 Transcription factor WhiB; Region: Whib; pfam02467 698965001859 PQQ-like domain; Region: PQQ_2; pfam13360 698965001860 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698965001861 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698965001862 ATP binding site [chemical binding]; other site 698965001863 putative Mg++ binding site [ion binding]; other site 698965001864 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698965001865 nucleotide binding region [chemical binding]; other site 698965001866 ATP-binding site [chemical binding]; other site 698965001867 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 698965001868 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 698965001869 TIGR02569 family protein; Region: TIGR02569_actnb 698965001870 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698965001871 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698965001872 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698965001873 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698965001874 Part of AAA domain; Region: AAA_19; pfam13245 698965001875 Family description; Region: UvrD_C_2; pfam13538 698965001876 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698965001877 Ion channel; Region: Ion_trans_2; pfam07885 698965001878 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 698965001879 TrkA-N domain; Region: TrkA_N; pfam02254 698965001880 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 698965001881 putative NADH binding site [chemical binding]; other site 698965001882 putative active site [active] 698965001883 nudix motif; other site 698965001884 putative metal binding site [ion binding]; other site 698965001885 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698965001886 Part of AAA domain; Region: AAA_19; pfam13245 698965001887 Family description; Region: UvrD_C_2; pfam13538 698965001888 HRDC domain; Region: HRDC; pfam00570 698965001889 Protein of unknown function DUF45; Region: DUF45; cl00636 698965001890 putative hydrolase; Region: TIGR03624 698965001891 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 698965001892 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698965001893 hypothetical protein; Validated; Region: PRK00068 698965001894 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 698965001895 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 698965001896 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698965001897 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698965001898 ATP binding site [chemical binding]; other site 698965001899 putative Mg++ binding site [ion binding]; other site 698965001900 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 698965001901 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698965001902 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698965001903 Presynaptic Site I dimer interface [polypeptide binding]; other site 698965001904 catalytic residues [active] 698965001905 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698965001906 Synaptic Flat tetramer interface [polypeptide binding]; other site 698965001907 Synaptic Site I dimer interface [polypeptide binding]; other site 698965001908 DNA binding site [nucleotide binding] 698965001909 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 698965001910 active site 698965001911 Protein of unknown function (DUF418); Region: DUF418; cl12135 698965001912 oxaloacetate decarboxylase; Provisional; Region: PRK12330 698965001913 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698965001914 active site 698965001915 catalytic residues [active] 698965001916 metal binding site [ion binding]; metal-binding site 698965001917 homodimer binding site [polypeptide binding]; other site 698965001918 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 698965001919 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698965001920 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698965001921 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698965001922 carboxyltransferase (CT) interaction site; other site 698965001923 biotinylation site [posttranslational modification]; other site 698965001924 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698965001925 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 698965001926 active site 698965001927 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698965001928 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698965001929 active site 698965001930 peptide chain release factor 2; Validated; Region: prfB; PRK00578 698965001931 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698965001932 RF-1 domain; Region: RF-1; pfam00472 698965001933 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 698965001934 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698965001935 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965001936 Walker A/P-loop; other site 698965001937 ATP binding site [chemical binding]; other site 698965001938 Q-loop/lid; other site 698965001939 ABC transporter signature motif; other site 698965001940 Walker B; other site 698965001941 D-loop; other site 698965001942 H-loop/switch region; other site 698965001943 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 698965001944 FtsX-like permease family; Region: FtsX; pfam02687 698965001945 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 698965001946 SmpB-tmRNA interface; other site 698965001947 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698965001948 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698965001949 HTH-like domain; Region: HTH_21; pfam13276 698965001950 Integrase core domain; Region: rve; pfam00665 698965001951 Integrase core domain; Region: rve_2; pfam13333 698965001952 Cupin domain; Region: Cupin_2; cl17218 698965001953 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 698965001954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698965001955 S-adenosylmethionine binding site [chemical binding]; other site 698965001956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698965001957 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698965001958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698965001959 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 698965001960 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698965001961 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698965001962 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698965001963 nucleotide binding region [chemical binding]; other site 698965001964 ATP-binding site [chemical binding]; other site 698965001965 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698965001966 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698965001967 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 698965001968 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698965001969 DNA-binding site [nucleotide binding]; DNA binding site 698965001970 RNA-binding motif; other site 698965001971 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 698965001972 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 698965001973 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 698965001974 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 698965001975 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698965001976 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698965001977 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 698965001978 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698965001979 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698965001980 catalytic residue [active] 698965001981 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 698965001982 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 698965001983 dimer interface [polypeptide binding]; other site 698965001984 active site 698965001985 citrylCoA binding site [chemical binding]; other site 698965001986 NADH binding [chemical binding]; other site 698965001987 cationic pore residues; other site 698965001988 oxalacetate/citrate binding site [chemical binding]; other site 698965001989 coenzyme A binding site [chemical binding]; other site 698965001990 catalytic triad [active] 698965001991 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698965001992 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 698965001993 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698965001994 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698965001995 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698965001996 active site 698965001997 catalytic tetrad [active] 698965001998 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 698965001999 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698965002000 substrate binding site [chemical binding]; other site 698965002001 oxyanion hole (OAH) forming residues; other site 698965002002 trimer interface [polypeptide binding]; other site 698965002003 Protein of unknown function, DUF485; Region: DUF485; pfam04341 698965002004 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698965002005 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 698965002006 Na binding site [ion binding]; other site 698965002007 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 698965002008 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 698965002009 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698965002010 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 698965002011 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 698965002012 active site 698965002013 SAM binding site [chemical binding]; other site 698965002014 homodimer interface [polypeptide binding]; other site 698965002015 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698965002016 catalytic residues [active] 698965002017 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 698965002018 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 698965002019 folate binding site [chemical binding]; other site 698965002020 NADP+ binding site [chemical binding]; other site 698965002021 thymidylate synthase; Reviewed; Region: thyA; PRK01827 698965002022 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 698965002023 dimerization interface [polypeptide binding]; other site 698965002024 active site 698965002025 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 698965002026 active site 698965002027 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698965002028 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 698965002029 ATP binding site [chemical binding]; other site 698965002030 putative Mg++ binding site [ion binding]; other site 698965002031 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698965002032 nucleotide binding region [chemical binding]; other site 698965002033 ATP-binding site [chemical binding]; other site 698965002034 DEAD/H associated; Region: DEAD_assoc; pfam08494 698965002035 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 698965002036 active site 698965002037 SUMO-1 interface [polypeptide binding]; other site 698965002038 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698965002039 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 698965002040 putative DNA binding site [nucleotide binding]; other site 698965002041 catalytic residue [active] 698965002042 putative H2TH interface [polypeptide binding]; other site 698965002043 putative catalytic residues [active] 698965002044 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698965002045 Predicted permease [General function prediction only]; Region: COG2985 698965002046 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698965002047 TrkA-C domain; Region: TrkA_C; pfam02080 698965002048 TrkA-C domain; Region: TrkA_C; pfam02080 698965002049 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698965002050 hypothetical protein; Provisional; Region: PRK11770 698965002051 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698965002052 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698965002053 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 698965002054 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 698965002055 active site 698965002056 dimer interface [polypeptide binding]; other site 698965002057 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 698965002058 dimer interface [polypeptide binding]; other site 698965002059 active site 698965002060 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698965002061 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698965002062 tetramerization interface [polypeptide binding]; other site 698965002063 NAD(P) binding site [chemical binding]; other site 698965002064 catalytic residues [active] 698965002065 hypothetical protein; Provisional; Region: PRK07857 698965002066 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 698965002067 Part of AAA domain; Region: AAA_19; pfam13245 698965002068 Family description; Region: UvrD_C_2; pfam13538 698965002069 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698965002070 Peptidase family M23; Region: Peptidase_M23; pfam01551 698965002071 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 698965002072 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 698965002073 active site 698965002074 substrate binding site [chemical binding]; other site 698965002075 cosubstrate binding site; other site 698965002076 catalytic site [active] 698965002077 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 698965002078 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 698965002079 purine monophosphate binding site [chemical binding]; other site 698965002080 dimer interface [polypeptide binding]; other site 698965002081 putative catalytic residues [active] 698965002082 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 698965002083 Late expression factor 8 (LEF-8); Region: LEF-8; pfam04941 698965002084 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 698965002085 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698965002086 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698965002087 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 698965002088 30S ribosomal protein S18; Provisional; Region: PRK13401 698965002089 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 698965002090 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 698965002091 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 698965002092 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 698965002093 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 698965002094 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698965002095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698965002096 active site 698965002097 phosphorylation site [posttranslational modification] 698965002098 intermolecular recognition site; other site 698965002099 dimerization interface [polypeptide binding]; other site 698965002100 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698965002101 DNA binding site [nucleotide binding] 698965002102 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698965002103 dimerization interface [polypeptide binding]; other site 698965002104 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698965002105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698965002106 dimer interface [polypeptide binding]; other site 698965002107 phosphorylation site [posttranslational modification] 698965002108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698965002109 ATP binding site [chemical binding]; other site 698965002110 Mg2+ binding site [ion binding]; other site 698965002111 G-X-G motif; other site 698965002112 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698965002113 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698965002114 protein binding site [polypeptide binding]; other site 698965002115 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698965002116 MPT binding site; other site 698965002117 trimer interface [polypeptide binding]; other site 698965002118 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 698965002119 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 698965002120 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 698965002121 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 698965002122 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 698965002123 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 698965002124 active site 698965002125 tetramer interface; other site 698965002126 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698965002127 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698965002128 dimer interface [polypeptide binding]; other site 698965002129 putative functional site; other site 698965002130 putative MPT binding site; other site 698965002131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698965002132 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698965002133 Predicted membrane protein [Function unknown]; Region: COG2259 698965002134 Predicted integral membrane protein [Function unknown]; Region: COG5660 698965002135 Putative zinc-finger; Region: zf-HC2; pfam13490 698965002136 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 698965002137 BCCT family transporter; Region: BCCT; pfam02028 698965002138 Uncharacterized membrane protein [Function unknown]; Region: COG3949 698965002139 Predicted methyltransferases [General function prediction only]; Region: COG0313 698965002140 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 698965002141 putative SAM binding site [chemical binding]; other site 698965002142 putative homodimer interface [polypeptide binding]; other site 698965002143 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 698965002144 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 698965002145 active site 698965002146 HIGH motif; other site 698965002147 KMSKS motif; other site 698965002148 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 698965002149 tRNA binding surface [nucleotide binding]; other site 698965002150 anticodon binding site; other site 698965002151 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 698965002152 active site 698965002153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 698965002154 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698965002155 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698965002156 G5 domain; Region: G5; pfam07501 698965002157 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698965002158 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 698965002159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698965002160 S-adenosylmethionine binding site [chemical binding]; other site 698965002161 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 698965002162 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698965002163 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698965002164 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698965002165 ABC transporter; Region: ABC_tran_2; pfam12848 698965002166 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698965002167 Uncharacterized conserved protein [Function unknown]; Region: COG1359 698965002168 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698965002169 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698965002170 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698965002171 DNA binding residues [nucleotide binding] 698965002172 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698965002173 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 698965002174 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698965002175 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698965002176 active site 698965002177 motif I; other site 698965002178 motif II; other site 698965002179 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698965002180 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 698965002181 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698965002182 substrate binding site [chemical binding]; other site 698965002183 oxyanion hole (OAH) forming residues; other site 698965002184 trimer interface [polypeptide binding]; other site 698965002185 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 698965002186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698965002187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698965002188 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 698965002189 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 698965002190 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698965002191 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698965002192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698965002193 NAD(P) binding site [chemical binding]; other site 698965002194 active site 698965002195 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698965002196 putative active site [active] 698965002197 catalytic residue [active] 698965002198 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698965002199 active site 698965002200 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698965002201 putative active site [active] 698965002202 catalytic residue [active] 698965002203 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 698965002204 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 698965002205 5S rRNA interface [nucleotide binding]; other site 698965002206 CTC domain interface [polypeptide binding]; other site 698965002207 L16 interface [polypeptide binding]; other site 698965002208 pullulanase, type I; Region: pulA_typeI; TIGR02104 698965002209 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 698965002210 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 698965002211 Ca binding site [ion binding]; other site 698965002212 active site 698965002213 catalytic site [active] 698965002214 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 698965002215 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 698965002216 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698965002217 active site 698965002218 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 698965002219 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 698965002220 Substrate binding site; other site 698965002221 Mg++ binding site; other site 698965002222 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 698965002223 active site 698965002224 substrate binding site [chemical binding]; other site 698965002225 CoA binding site [chemical binding]; other site 698965002226 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698965002227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698965002228 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 698965002229 putative dimerization interface [polypeptide binding]; other site 698965002230 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 698965002231 gating phenylalanine in ion channel; other site 698965002232 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698965002233 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 698965002234 putative ligand binding site [chemical binding]; other site 698965002235 putative NAD binding site [chemical binding]; other site 698965002236 catalytic site [active] 698965002237 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698965002238 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698965002239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965002240 Q-loop/lid; other site 698965002241 ABC transporter signature motif; other site 698965002242 Walker B; other site 698965002243 D-loop; other site 698965002244 H-loop/switch region; other site 698965002245 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698965002246 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698965002247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965002248 Walker A/P-loop; other site 698965002249 ATP binding site [chemical binding]; other site 698965002250 Q-loop/lid; other site 698965002251 ABC transporter signature motif; other site 698965002252 Walker B; other site 698965002253 D-loop; other site 698965002254 H-loop/switch region; other site 698965002255 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698965002256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698965002257 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 698965002258 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 698965002259 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698965002260 ATP binding site [chemical binding]; other site 698965002261 putative Mg++ binding site [ion binding]; other site 698965002262 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698965002263 nucleotide binding region [chemical binding]; other site 698965002264 ATP-binding site [chemical binding]; other site 698965002265 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 698965002266 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 698965002267 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 698965002268 homodimer interface [polypeptide binding]; other site 698965002269 metal binding site [ion binding]; metal-binding site 698965002270 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 698965002271 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698965002272 enolase; Provisional; Region: eno; PRK00077 698965002273 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 698965002274 dimer interface [polypeptide binding]; other site 698965002275 metal binding site [ion binding]; metal-binding site 698965002276 substrate binding pocket [chemical binding]; other site 698965002277 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 698965002278 Septum formation initiator; Region: DivIC; pfam04977 698965002279 Uncharacterized conserved protein [Function unknown]; Region: COG1507 698965002280 exopolyphosphatase; Region: exo_poly_only; TIGR03706 698965002281 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698965002282 Excalibur calcium-binding domain; Region: Excalibur; smart00894 698965002283 Helix-turn-helix domain; Region: HTH_18; pfam12833 698965002284 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698965002285 Bax inhibitor 1 like; Region: BaxI_1; cl17691 698965002286 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 698965002287 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 698965002288 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 698965002289 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 698965002290 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 698965002291 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 698965002292 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698965002293 catalytic residue [active] 698965002294 putative FPP diphosphate binding site; other site 698965002295 putative FPP binding hydrophobic cleft; other site 698965002296 dimer interface [polypeptide binding]; other site 698965002297 putative IPP diphosphate binding site; other site 698965002298 Flavodoxin domain; Region: Flavodoxin_5; cl17428 698965002299 pantothenate kinase; Provisional; Region: PRK05439 698965002300 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 698965002301 ATP-binding site [chemical binding]; other site 698965002302 CoA-binding site [chemical binding]; other site 698965002303 Mg2+-binding site [ion binding]; other site 698965002304 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 698965002305 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 698965002306 dimer interface [polypeptide binding]; other site 698965002307 active site 698965002308 glycine-pyridoxal phosphate binding site [chemical binding]; other site 698965002309 folate binding site [chemical binding]; other site 698965002310 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698965002311 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 698965002312 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698965002313 Coenzyme A binding pocket [chemical binding]; other site 698965002314 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698965002315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965002316 putative substrate translocation pore; other site 698965002317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965002318 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698965002319 fumarate hydratase; Reviewed; Region: fumC; PRK00485 698965002320 Class II fumarases; Region: Fumarase_classII; cd01362 698965002321 active site 698965002322 tetramer interface [polypeptide binding]; other site 698965002323 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 698965002324 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 698965002325 putative active site [active] 698965002326 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 698965002327 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 698965002328 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 698965002329 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 698965002330 generic binding surface II; other site 698965002331 generic binding surface I; other site 698965002332 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 698965002333 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 698965002334 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698965002335 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698965002336 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 698965002337 Na2 binding site [ion binding]; other site 698965002338 putative substrate binding site 1 [chemical binding]; other site 698965002339 Na binding site 1 [ion binding]; other site 698965002340 putative substrate binding site 2 [chemical binding]; other site 698965002341 GTP-binding protein YchF; Reviewed; Region: PRK09601 698965002342 YchF GTPase; Region: YchF; cd01900 698965002343 G1 box; other site 698965002344 GTP/Mg2+ binding site [chemical binding]; other site 698965002345 Switch I region; other site 698965002346 G2 box; other site 698965002347 Switch II region; other site 698965002348 G3 box; other site 698965002349 G4 box; other site 698965002350 G5 box; other site 698965002351 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 698965002352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 698965002353 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 698965002354 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 698965002355 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 698965002356 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 698965002357 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 698965002358 Cl- selectivity filter; other site 698965002359 Cl- binding residues [ion binding]; other site 698965002360 pore gating glutamate residue; other site 698965002361 dimer interface [polypeptide binding]; other site 698965002362 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698965002363 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698965002364 Walker A/P-loop; other site 698965002365 ATP binding site [chemical binding]; other site 698965002366 Q-loop/lid; other site 698965002367 ABC transporter signature motif; other site 698965002368 Walker B; other site 698965002369 D-loop; other site 698965002370 H-loop/switch region; other site 698965002371 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 698965002372 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698965002373 Walker A/P-loop; other site 698965002374 ATP binding site [chemical binding]; other site 698965002375 Q-loop/lid; other site 698965002376 ABC transporter signature motif; other site 698965002377 Walker B; other site 698965002378 D-loop; other site 698965002379 H-loop/switch region; other site 698965002380 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698965002381 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 698965002382 active site 698965002383 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698965002384 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698965002385 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698965002386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698965002387 dimer interface [polypeptide binding]; other site 698965002388 conserved gate region; other site 698965002389 ABC-ATPase subunit interface; other site 698965002390 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698965002391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698965002392 dimer interface [polypeptide binding]; other site 698965002393 conserved gate region; other site 698965002394 putative PBP binding loops; other site 698965002395 ABC-ATPase subunit interface; other site 698965002396 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698965002397 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698965002398 Walker A/P-loop; other site 698965002399 ATP binding site [chemical binding]; other site 698965002400 Q-loop/lid; other site 698965002401 ABC transporter signature motif; other site 698965002402 Walker B; other site 698965002403 D-loop; other site 698965002404 H-loop/switch region; other site 698965002405 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698965002406 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698965002407 Walker A/P-loop; other site 698965002408 ATP binding site [chemical binding]; other site 698965002409 Q-loop/lid; other site 698965002410 ABC transporter signature motif; other site 698965002411 Walker B; other site 698965002412 D-loop; other site 698965002413 H-loop/switch region; other site 698965002414 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698965002415 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698965002416 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965002417 Walker A/P-loop; other site 698965002418 ATP binding site [chemical binding]; other site 698965002419 ABC transporter signature motif; other site 698965002420 Walker B; other site 698965002421 D-loop; other site 698965002422 H-loop/switch region; other site 698965002423 Trypsin; Region: Trypsin; pfam00089 698965002424 active site 698965002425 substrate binding sites [chemical binding]; other site 698965002426 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 698965002427 ArsC family; Region: ArsC; pfam03960 698965002428 catalytic residues [active] 698965002429 Protein of unknown function (DUF402); Region: DUF402; cl00979 698965002430 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 698965002431 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 698965002432 G1 box; other site 698965002433 GTP/Mg2+ binding site [chemical binding]; other site 698965002434 G2 box; other site 698965002435 Switch I region; other site 698965002436 G3 box; other site 698965002437 Switch II region; other site 698965002438 G4 box; other site 698965002439 G5 box; other site 698965002440 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 698965002441 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 698965002442 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 698965002443 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698965002444 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 698965002445 Ferredoxin [Energy production and conversion]; Region: COG1146 698965002446 4Fe-4S binding domain; Region: Fer4; pfam00037 698965002447 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 698965002448 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698965002449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698965002450 homodimer interface [polypeptide binding]; other site 698965002451 catalytic residue [active] 698965002452 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698965002453 active site 698965002454 Predicted membrane protein [Function unknown]; Region: COG2246 698965002455 GtrA-like protein; Region: GtrA; pfam04138 698965002456 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698965002457 active site 698965002458 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 698965002459 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698965002460 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 698965002461 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 698965002462 putative trimer interface [polypeptide binding]; other site 698965002463 putative CoA binding site [chemical binding]; other site 698965002464 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 698965002465 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698965002466 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 698965002467 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698965002468 putative trimer interface [polypeptide binding]; other site 698965002469 putative CoA binding site [chemical binding]; other site 698965002470 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 698965002471 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 698965002472 metal binding site [ion binding]; metal-binding site 698965002473 putative dimer interface [polypeptide binding]; other site 698965002474 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698965002475 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698965002476 dihydropteroate synthase; Region: DHPS; TIGR01496 698965002477 substrate binding pocket [chemical binding]; other site 698965002478 dimer interface [polypeptide binding]; other site 698965002479 inhibitor binding site; inhibition site 698965002480 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 698965002481 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 698965002482 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 698965002483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698965002484 S-adenosylmethionine binding site [chemical binding]; other site 698965002485 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 698965002486 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 698965002487 active site 698965002488 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 698965002489 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 698965002490 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 698965002491 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698965002492 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 698965002493 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 698965002494 ligand binding site; other site 698965002495 oligomer interface; other site 698965002496 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 698965002497 dimer interface [polypeptide binding]; other site 698965002498 N-terminal domain interface [polypeptide binding]; other site 698965002499 sulfate 1 binding site; other site 698965002500 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 698965002501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698965002502 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 698965002503 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698965002504 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698965002505 DNA binding residues [nucleotide binding] 698965002506 Putative zinc-finger; Region: zf-HC2; pfam13490 698965002507 sec-independent translocase; Provisional; Region: tatB; PRK00182 698965002508 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 698965002509 Domain of unknown function DUF59; Region: DUF59; pfam01883 698965002510 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 698965002511 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 698965002512 Predicted membrane protein [Function unknown]; Region: COG4420 698965002513 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 698965002514 MgtE intracellular N domain; Region: MgtE_N; smart00924 698965002515 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 698965002516 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 698965002517 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 698965002518 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698965002519 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 698965002520 TPP-binding site [chemical binding]; other site 698965002521 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 698965002522 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698965002523 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698965002524 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965002525 Walker A/P-loop; other site 698965002526 ATP binding site [chemical binding]; other site 698965002527 Q-loop/lid; other site 698965002528 ABC transporter signature motif; other site 698965002529 Walker B; other site 698965002530 D-loop; other site 698965002531 H-loop/switch region; other site 698965002532 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698965002533 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698965002534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965002535 Walker A/P-loop; other site 698965002536 ATP binding site [chemical binding]; other site 698965002537 Q-loop/lid; other site 698965002538 ABC transporter signature motif; other site 698965002539 Walker B; other site 698965002540 D-loop; other site 698965002541 H-loop/switch region; other site 698965002542 Transposase; Region: DDE_Tnp_ISL3; pfam01610 698965002543 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 698965002544 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698965002545 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698965002546 shikimate binding site; other site 698965002547 NAD(P) binding site [chemical binding]; other site 698965002548 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698965002549 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698965002550 substrate binding pocket [chemical binding]; other site 698965002551 catalytic triad [active] 698965002552 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 698965002553 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 698965002554 active site 698965002555 catalytic residues [active] 698965002556 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 698965002557 putative transporter; Provisional; Region: PRK10484 698965002558 Na binding site [ion binding]; other site 698965002559 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698965002560 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 698965002561 nucleotide binding site/active site [active] 698965002562 HIT family signature motif; other site 698965002563 catalytic residue [active] 698965002564 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 698965002565 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698965002566 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698965002567 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698965002568 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 698965002569 PLD-like domain; Region: PLDc_2; pfam13091 698965002570 putative homodimer interface [polypeptide binding]; other site 698965002571 putative active site [active] 698965002572 catalytic site [active] 698965002573 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698965002574 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698965002575 putative Mg++ binding site [ion binding]; other site 698965002576 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698965002577 nucleotide binding region [chemical binding]; other site 698965002578 ATP-binding site [chemical binding]; other site 698965002579 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 698965002580 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 698965002581 active site 698965002582 8-oxo-dGMP binding site [chemical binding]; other site 698965002583 nudix motif; other site 698965002584 metal binding site [ion binding]; metal-binding site 698965002585 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 698965002586 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698965002587 ATP binding site [chemical binding]; other site 698965002588 Mg++ binding site [ion binding]; other site 698965002589 motif III; other site 698965002590 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698965002591 nucleotide binding region [chemical binding]; other site 698965002592 ATP-binding site [chemical binding]; other site 698965002593 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 698965002594 putative RNA binding site [nucleotide binding]; other site 698965002595 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698965002596 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698965002597 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 698965002598 Na binding site [ion binding]; other site 698965002599 SNF2 Helicase protein; Region: DUF3670; pfam12419 698965002600 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 698965002601 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698965002602 ATP binding site [chemical binding]; other site 698965002603 putative Mg++ binding site [ion binding]; other site 698965002604 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698965002605 nucleotide binding region [chemical binding]; other site 698965002606 ATP-binding site [chemical binding]; other site 698965002607 Uncharacterized conserved protein [Function unknown]; Region: COG4279 698965002608 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 698965002609 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 698965002610 active site 698965002611 metal binding site [ion binding]; metal-binding site 698965002612 DNA binding site [nucleotide binding] 698965002613 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 698965002614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965002615 Walker A/P-loop; other site 698965002616 ATP binding site [chemical binding]; other site 698965002617 Q-loop/lid; other site 698965002618 Uncharacterized conserved protein [Function unknown]; Region: COG2353 698965002619 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698965002620 MarR family; Region: MarR_2; pfam12802 698965002621 PspC domain; Region: PspC; cl00864 698965002622 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698965002623 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 698965002624 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698965002625 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 698965002626 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698965002627 Cysteine-rich domain; Region: CCG; pfam02754 698965002628 Cysteine-rich domain; Region: CCG; pfam02754 698965002629 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698965002630 L-lactate permease; Region: Lactate_perm; cl00701 698965002631 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 698965002632 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 698965002633 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 698965002634 active site 698965002635 HIGH motif; other site 698965002636 KMSK motif region; other site 698965002637 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 698965002638 tRNA binding surface [nucleotide binding]; other site 698965002639 anticodon binding site; other site 698965002640 diaminopimelate decarboxylase; Region: lysA; TIGR01048 698965002641 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 698965002642 active site 698965002643 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698965002644 substrate binding site [chemical binding]; other site 698965002645 catalytic residues [active] 698965002646 dimer interface [polypeptide binding]; other site 698965002647 homoserine dehydrogenase; Provisional; Region: PRK06349 698965002648 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 698965002649 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 698965002650 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 698965002651 homoserine kinase; Provisional; Region: PRK01212 698965002652 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 698965002653 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698965002654 acyl-activating enzyme (AAE) consensus motif; other site 698965002655 AMP binding site [chemical binding]; other site 698965002656 active site 698965002657 CoA binding site [chemical binding]; other site 698965002658 transcription termination factor Rho; Provisional; Region: PRK12678 698965002659 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 698965002660 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698965002661 RNA binding site [nucleotide binding]; other site 698965002662 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 698965002663 multimer interface [polypeptide binding]; other site 698965002664 Walker A motif; other site 698965002665 ATP binding site [chemical binding]; other site 698965002666 Walker B motif; other site 698965002667 peptide chain release factor 1; Validated; Region: prfA; PRK00591 698965002668 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698965002669 RF-1 domain; Region: RF-1; pfam00472 698965002670 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 698965002671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698965002672 S-adenosylmethionine binding site [chemical binding]; other site 698965002673 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 698965002674 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 698965002675 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 698965002676 Mg++ binding site [ion binding]; other site 698965002677 putative catalytic motif [active] 698965002678 substrate binding site [chemical binding]; other site 698965002679 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 698965002680 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 698965002681 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 698965002682 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 698965002683 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 698965002684 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 698965002685 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 698965002686 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 698965002687 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698965002688 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 698965002689 beta subunit interaction interface [polypeptide binding]; other site 698965002690 Walker A motif; other site 698965002691 ATP binding site [chemical binding]; other site 698965002692 Walker B motif; other site 698965002693 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698965002694 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 698965002695 core domain interface [polypeptide binding]; other site 698965002696 delta subunit interface [polypeptide binding]; other site 698965002697 epsilon subunit interface [polypeptide binding]; other site 698965002698 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 698965002699 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698965002700 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 698965002701 alpha subunit interaction interface [polypeptide binding]; other site 698965002702 Walker A motif; other site 698965002703 ATP binding site [chemical binding]; other site 698965002704 Walker B motif; other site 698965002705 inhibitor binding site; inhibition site 698965002706 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698965002707 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 698965002708 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 698965002709 gamma subunit interface [polypeptide binding]; other site 698965002710 epsilon subunit interface [polypeptide binding]; other site 698965002711 LBP interface [polypeptide binding]; other site 698965002712 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 698965002713 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 698965002714 hypothetical protein; Provisional; Region: PRK03298 698965002715 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 698965002716 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698965002717 dimer interface [polypeptide binding]; other site 698965002718 substrate binding site [chemical binding]; other site 698965002719 metal binding site [ion binding]; metal-binding site 698965002720 Domain of unknown function DUF77; Region: DUF77; pfam01910 698965002721 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698965002722 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698965002723 Walker A/P-loop; other site 698965002724 ATP binding site [chemical binding]; other site 698965002725 Q-loop/lid; other site 698965002726 ABC transporter signature motif; other site 698965002727 Walker B; other site 698965002728 D-loop; other site 698965002729 H-loop/switch region; other site 698965002730 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698965002731 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698965002732 ABC-ATPase subunit interface; other site 698965002733 dimer interface [polypeptide binding]; other site 698965002734 putative PBP binding regions; other site 698965002735 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698965002736 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698965002737 ABC-ATPase subunit interface; other site 698965002738 dimer interface [polypeptide binding]; other site 698965002739 putative PBP binding regions; other site 698965002740 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698965002741 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698965002742 siderophore binding site; other site 698965002743 TIGR02611 family protein; Region: TIGR02611 698965002744 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 698965002745 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 698965002746 glycogen branching enzyme; Provisional; Region: PRK05402 698965002747 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 698965002748 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 698965002749 active site 698965002750 catalytic site [active] 698965002751 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 698965002752 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 698965002753 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 698965002754 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698965002755 active site 698965002756 homodimer interface [polypeptide binding]; other site 698965002757 catalytic site [active] 698965002758 acceptor binding site [chemical binding]; other site 698965002759 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698965002760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965002761 Walker A/P-loop; other site 698965002762 ATP binding site [chemical binding]; other site 698965002763 Q-loop/lid; other site 698965002764 ABC transporter signature motif; other site 698965002765 Walker B; other site 698965002766 D-loop; other site 698965002767 H-loop/switch region; other site 698965002768 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 698965002769 Ligand binding site [chemical binding]; other site 698965002770 Electron transfer flavoprotein domain; Region: ETF; pfam01012 698965002771 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 698965002772 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 698965002773 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 698965002774 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 698965002775 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 698965002776 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698965002777 catalytic residue [active] 698965002778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698965002779 S-adenosylmethionine binding site [chemical binding]; other site 698965002780 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 698965002781 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 698965002782 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698965002783 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698965002784 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698965002785 active site 698965002786 catalytic site [active] 698965002787 substrate binding site [chemical binding]; other site 698965002788 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 698965002789 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 698965002790 nucleotide binding pocket [chemical binding]; other site 698965002791 K-X-D-G motif; other site 698965002792 catalytic site [active] 698965002793 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 698965002794 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 698965002795 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 698965002796 Dimer interface [polypeptide binding]; other site 698965002797 BRCT sequence motif; other site 698965002798 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698965002799 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 698965002800 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698965002801 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 698965002802 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 698965002803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698965002804 Coenzyme A binding pocket [chemical binding]; other site 698965002805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965002806 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698965002807 putative substrate translocation pore; other site 698965002808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965002809 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698965002810 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698965002811 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698965002812 ABC-ATPase subunit interface; other site 698965002813 dimer interface [polypeptide binding]; other site 698965002814 putative PBP binding regions; other site 698965002815 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698965002816 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965002817 Walker A/P-loop; other site 698965002818 ATP binding site [chemical binding]; other site 698965002819 Q-loop/lid; other site 698965002820 ABC transporter signature motif; other site 698965002821 Walker B; other site 698965002822 D-loop; other site 698965002823 H-loop/switch region; other site 698965002824 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 698965002825 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 698965002826 putative ligand binding residues [chemical binding]; other site 698965002827 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 698965002828 phosphofructokinase; Region: PFK_mixed; TIGR02483 698965002829 active site 698965002830 ADP/pyrophosphate binding site [chemical binding]; other site 698965002831 dimerization interface [polypeptide binding]; other site 698965002832 allosteric effector site; other site 698965002833 fructose-1,6-bisphosphate binding site; other site 698965002834 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 698965002835 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 698965002836 GatB domain; Region: GatB_Yqey; smart00845 698965002837 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698965002838 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698965002839 active site 698965002840 catalytic tetrad [active] 698965002841 Lysine efflux permease [General function prediction only]; Region: COG1279 698965002842 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 698965002843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698965002844 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698965002845 dimerization interface [polypeptide binding]; other site 698965002846 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 698965002847 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 698965002848 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 698965002849 putative dimer interface [polypeptide binding]; other site 698965002850 N-terminal domain interface [polypeptide binding]; other site 698965002851 putative substrate binding pocket (H-site) [chemical binding]; other site 698965002852 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698965002853 Predicted membrane protein [Function unknown]; Region: COG2259 698965002854 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 698965002855 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698965002856 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 698965002857 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698965002858 PYR/PP interface [polypeptide binding]; other site 698965002859 dimer interface [polypeptide binding]; other site 698965002860 TPP binding site [chemical binding]; other site 698965002861 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698965002862 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 698965002863 TPP-binding site [chemical binding]; other site 698965002864 dimer interface [polypeptide binding]; other site 698965002865 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 698965002866 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 698965002867 putative valine binding site [chemical binding]; other site 698965002868 dimer interface [polypeptide binding]; other site 698965002869 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 698965002870 ketol-acid reductoisomerase; Provisional; Region: PRK05479 698965002871 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 698965002872 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 698965002873 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 698965002874 Uncharacterized conserved protein [Function unknown]; Region: COG1479 698965002875 Protein of unknown function DUF262; Region: DUF262; pfam03235 698965002876 Uncharacterized conserved protein [Function unknown]; Region: COG3472 698965002877 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 698965002878 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 698965002879 ligand binding site [chemical binding]; other site 698965002880 NAD binding site [chemical binding]; other site 698965002881 dimerization interface [polypeptide binding]; other site 698965002882 catalytic site [active] 698965002883 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 698965002884 putative L-serine binding site [chemical binding]; other site 698965002885 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 698965002886 tartrate dehydrogenase; Region: TTC; TIGR02089 698965002887 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698965002888 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698965002889 active site 698965002890 catalytic site [active] 698965002891 substrate binding site [chemical binding]; other site 698965002892 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 698965002893 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 698965002894 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 698965002895 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 698965002896 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698965002897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698965002898 S-adenosylmethionine binding site [chemical binding]; other site 698965002899 isochorismate synthase DhbC; Validated; Region: PRK06923 698965002900 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698965002901 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 698965002902 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698965002903 active site 698965002904 HIGH motif; other site 698965002905 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698965002906 active site 698965002907 KMSKS motif; other site 698965002908 Helix-turn-helix domain; Region: HTH_38; pfam13936 698965002909 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698965002910 Integrase core domain; Region: rve; pfam00665 698965002911 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 698965002912 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698965002913 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698965002914 MMPL family; Region: MMPL; pfam03176 698965002915 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 698965002916 MMPL family; Region: MMPL; pfam03176 698965002917 Cutinase; Region: Cutinase; pfam01083 698965002918 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 698965002919 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 698965002920 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 698965002921 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 698965002922 PhnA protein; Region: PhnA; pfam03831 698965002923 biotin synthase; Region: bioB; TIGR00433 698965002924 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698965002925 FeS/SAM binding site; other site 698965002926 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698965002927 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698965002928 HD domain; Region: HD_4; pfam13328 698965002929 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698965002930 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698965002931 putative DNA binding site [nucleotide binding]; other site 698965002932 putative Zn2+ binding site [ion binding]; other site 698965002933 Bacterial transcriptional regulator; Region: IclR; pfam01614 698965002934 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 698965002935 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 698965002936 substrate binding site [chemical binding]; other site 698965002937 ligand binding site [chemical binding]; other site 698965002938 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 698965002939 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 698965002940 substrate binding site [chemical binding]; other site 698965002941 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698965002942 active site 698965002943 Ap6A binding site [chemical binding]; other site 698965002944 nudix motif; other site 698965002945 metal binding site [ion binding]; metal-binding site 698965002946 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698965002947 catalytic core [active] 698965002948 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 698965002949 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698965002950 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 698965002951 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 698965002952 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 698965002953 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698965002954 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698965002955 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698965002956 thiamine monophosphate kinase; Provisional; Region: PRK05731 698965002957 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 698965002958 ATP binding site [chemical binding]; other site 698965002959 dimerization interface [polypeptide binding]; other site 698965002960 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 698965002961 ligand binding site [chemical binding]; other site 698965002962 active site 698965002963 UGI interface [polypeptide binding]; other site 698965002964 catalytic site [active] 698965002965 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 698965002966 DAK2 domain; Region: Dak2; pfam02734 698965002967 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 698965002968 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 698965002969 generic binding surface II; other site 698965002970 ssDNA binding site; other site 698965002971 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698965002972 ATP binding site [chemical binding]; other site 698965002973 putative Mg++ binding site [ion binding]; other site 698965002974 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698965002975 nucleotide binding region [chemical binding]; other site 698965002976 ATP-binding site [chemical binding]; other site 698965002977 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 698965002978 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698965002979 carboxyltransferase (CT) interaction site; other site 698965002980 biotinylation site [posttranslational modification]; other site 698965002981 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 698965002982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698965002983 S-adenosylmethionine binding site [chemical binding]; other site 698965002984 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 698965002985 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 698965002986 active site 698965002987 (T/H)XGH motif; other site 698965002988 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698965002989 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698965002990 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698965002991 Walker A/P-loop; other site 698965002992 ATP binding site [chemical binding]; other site 698965002993 Q-loop/lid; other site 698965002994 ABC transporter signature motif; other site 698965002995 Walker B; other site 698965002996 D-loop; other site 698965002997 H-loop/switch region; other site 698965002998 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698965002999 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698965003000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698965003001 dimer interface [polypeptide binding]; other site 698965003002 conserved gate region; other site 698965003003 putative PBP binding loops; other site 698965003004 ABC-ATPase subunit interface; other site 698965003005 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698965003006 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698965003007 substrate binding pocket [chemical binding]; other site 698965003008 membrane-bound complex binding site; other site 698965003009 hinge residues; other site 698965003010 Domain of unknown function (DUF368); Region: DUF368; pfam04018 698965003011 Helix-turn-helix domain; Region: HTH_38; pfam13936 698965003012 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698965003013 Integrase core domain; Region: rve; pfam00665 698965003014 DNA polymerase I; Provisional; Region: PRK05755 698965003015 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 698965003016 active site 698965003017 metal binding site 1 [ion binding]; metal-binding site 698965003018 putative 5' ssDNA interaction site; other site 698965003019 metal binding site 3; metal-binding site 698965003020 metal binding site 2 [ion binding]; metal-binding site 698965003021 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 698965003022 putative DNA binding site [nucleotide binding]; other site 698965003023 putative metal binding site [ion binding]; other site 698965003024 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 698965003025 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 698965003026 active site 698965003027 DNA binding site [nucleotide binding] 698965003028 catalytic site [active] 698965003029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698965003030 S-adenosylmethionine binding site [chemical binding]; other site 698965003031 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 698965003032 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 698965003033 RNA binding site [nucleotide binding]; other site 698965003034 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 698965003035 RNA binding site [nucleotide binding]; other site 698965003036 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698965003037 RNA binding site [nucleotide binding]; other site 698965003038 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 698965003039 RNA binding site [nucleotide binding]; other site 698965003040 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 698965003041 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 698965003042 transcriptional antiterminator BglG; Provisional; Region: PRK09772 698965003043 CAT RNA binding domain; Region: CAT_RBD; smart01061 698965003044 PRD domain; Region: PRD; pfam00874 698965003045 PRD domain; Region: PRD; pfam00874 698965003046 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 698965003047 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698965003048 active site turn [active] 698965003049 phosphorylation site [posttranslational modification] 698965003050 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698965003051 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 698965003052 HPr interaction site; other site 698965003053 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698965003054 active site 698965003055 phosphorylation site [posttranslational modification] 698965003056 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 698965003057 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 698965003058 CoA-binding site [chemical binding]; other site 698965003059 ATP-binding [chemical binding]; other site 698965003060 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 698965003061 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698965003062 FeS/SAM binding site; other site 698965003063 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 698965003064 excinuclease ABC subunit B; Provisional; Region: PRK05298 698965003065 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698965003066 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698965003067 nucleotide binding region [chemical binding]; other site 698965003068 ATP-binding site [chemical binding]; other site 698965003069 Ultra-violet resistance protein B; Region: UvrB; pfam12344 698965003070 UvrB/uvrC motif; Region: UVR; pfam02151 698965003071 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698965003072 Ligand Binding Site [chemical binding]; other site 698965003073 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 698965003074 Part of AAA domain; Region: AAA_19; pfam13245 698965003075 PhoH-like protein; Region: PhoH; cl17668 698965003076 Family description; Region: UvrD_C_2; pfam13538 698965003077 Predicted membrane protein [Function unknown]; Region: COG2259 698965003078 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698965003079 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 698965003080 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698965003081 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698965003082 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 698965003083 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 698965003084 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 698965003085 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 698965003086 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 698965003087 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 698965003088 23S rRNA binding site [nucleotide binding]; other site 698965003089 L21 binding site [polypeptide binding]; other site 698965003090 L13 binding site [polypeptide binding]; other site 698965003091 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698965003092 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 698965003093 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698965003094 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 698965003095 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 698965003096 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 698965003097 dimer interface [polypeptide binding]; other site 698965003098 motif 1; other site 698965003099 active site 698965003100 motif 2; other site 698965003101 motif 3; other site 698965003102 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 698965003103 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 698965003104 putative tRNA-binding site [nucleotide binding]; other site 698965003105 B3/4 domain; Region: B3_4; pfam03483 698965003106 tRNA synthetase B5 domain; Region: B5; smart00874 698965003107 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 698965003108 dimer interface [polypeptide binding]; other site 698965003109 motif 1; other site 698965003110 motif 3; other site 698965003111 motif 2; other site 698965003112 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 698965003113 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 698965003114 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698965003115 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 698965003116 heterotetramer interface [polypeptide binding]; other site 698965003117 active site pocket [active] 698965003118 cleavage site 698965003119 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 698965003120 feedback inhibition sensing region; other site 698965003121 homohexameric interface [polypeptide binding]; other site 698965003122 nucleotide binding site [chemical binding]; other site 698965003123 N-acetyl-L-glutamate binding site [chemical binding]; other site 698965003124 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 698965003125 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698965003126 inhibitor-cofactor binding pocket; inhibition site 698965003127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698965003128 catalytic residue [active] 698965003129 ornithine carbamoyltransferase; Provisional; Region: PRK00779 698965003130 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698965003131 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698965003132 arginine repressor; Provisional; Region: PRK03341 698965003133 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 698965003134 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 698965003135 argininosuccinate synthase; Provisional; Region: PRK13820 698965003136 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 698965003137 ANP binding site [chemical binding]; other site 698965003138 Substrate Binding Site II [chemical binding]; other site 698965003139 Substrate Binding Site I [chemical binding]; other site 698965003140 argininosuccinate lyase; Provisional; Region: PRK00855 698965003141 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 698965003142 active sites [active] 698965003143 tetramer interface [polypeptide binding]; other site 698965003144 Uncharacterized conserved protein [Function unknown]; Region: COG2835 698965003145 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 698965003146 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 698965003147 active site 698965003148 HIGH motif; other site 698965003149 dimer interface [polypeptide binding]; other site 698965003150 KMSKS motif; other site 698965003151 S4 RNA-binding domain; Region: S4; smart00363 698965003152 transcription termination factor Rho; Provisional; Region: PRK12678 698965003153 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698965003154 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698965003155 active site 698965003156 motif I; other site 698965003157 motif II; other site 698965003158 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698965003159 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 698965003160 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698965003161 RNA binding surface [nucleotide binding]; other site 698965003162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698965003163 S-adenosylmethionine binding site [chemical binding]; other site 698965003164 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 698965003165 ATP-NAD kinase; Region: NAD_kinase; pfam01513 698965003166 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 698965003167 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698965003168 Walker A/P-loop; other site 698965003169 ATP binding site [chemical binding]; other site 698965003170 Q-loop/lid; other site 698965003171 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698965003172 ABC transporter signature motif; other site 698965003173 Walker B; other site 698965003174 D-loop; other site 698965003175 H-loop/switch region; other site 698965003176 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 698965003177 Thiamine pyrophosphokinase; Region: TPK; cl08415 698965003178 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 698965003179 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 698965003180 dimer interface [polypeptide binding]; other site 698965003181 ADP-ribose binding site [chemical binding]; other site 698965003182 active site 698965003183 nudix motif; other site 698965003184 metal binding site [ion binding]; metal-binding site 698965003185 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 698965003186 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 698965003187 active site 698965003188 Int/Topo IB signature motif; other site 698965003189 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698965003190 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698965003191 P-loop; other site 698965003192 Magnesium ion binding site [ion binding]; other site 698965003193 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698965003194 Magnesium ion binding site [ion binding]; other site 698965003195 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 698965003196 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698965003197 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 698965003198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965003199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965003200 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 698965003201 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698965003202 inhibitor-cofactor binding pocket; inhibition site 698965003203 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698965003204 catalytic residue [active] 698965003205 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698965003206 AAA domain; Region: AAA_26; pfam13500 698965003207 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 698965003208 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 698965003209 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698965003210 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698965003211 RNA binding surface [nucleotide binding]; other site 698965003212 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 698965003213 active site 698965003214 cytidylate kinase; Provisional; Region: cmk; PRK00023 698965003215 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 698965003216 CMP-binding site; other site 698965003217 The sites determining sugar specificity; other site 698965003218 GTP-binding protein Der; Reviewed; Region: PRK03003 698965003219 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 698965003220 G1 box; other site 698965003221 GTP/Mg2+ binding site [chemical binding]; other site 698965003222 Switch I region; other site 698965003223 G2 box; other site 698965003224 Switch II region; other site 698965003225 G3 box; other site 698965003226 G4 box; other site 698965003227 G5 box; other site 698965003228 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 698965003229 G1 box; other site 698965003230 GTP/Mg2+ binding site [chemical binding]; other site 698965003231 Switch I region; other site 698965003232 G2 box; other site 698965003233 G3 box; other site 698965003234 Switch II region; other site 698965003235 G4 box; other site 698965003236 G5 box; other site 698965003237 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698965003238 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 698965003239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698965003240 S-adenosylmethionine binding site [chemical binding]; other site 698965003241 Putative esterase; Region: Esterase; pfam00756 698965003242 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698965003243 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 698965003244 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698965003245 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 698965003246 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698965003247 nucleotide binding region [chemical binding]; other site 698965003248 ATP-binding site [chemical binding]; other site 698965003249 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698965003250 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698965003251 phosphopeptide binding site; other site 698965003252 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 698965003253 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698965003254 DNA binding residues [nucleotide binding] 698965003255 Bifunctional nuclease; Region: DNase-RNase; pfam02577 698965003256 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 698965003257 DNA binding residues [nucleotide binding] 698965003258 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698965003259 putative dimer interface [polypeptide binding]; other site 698965003260 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698965003261 metal ion-dependent adhesion site (MIDAS); other site 698965003262 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698965003263 Domain of unknown function DUF21; Region: DUF21; pfam01595 698965003264 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698965003265 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698965003266 Domain of unknown function DUF21; Region: DUF21; pfam01595 698965003267 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698965003268 Transporter associated domain; Region: CorC_HlyC; smart01091 698965003269 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 698965003270 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698965003271 ATP binding site [chemical binding]; other site 698965003272 Mg++ binding site [ion binding]; other site 698965003273 motif III; other site 698965003274 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698965003275 nucleotide binding region [chemical binding]; other site 698965003276 ATP-binding site [chemical binding]; other site 698965003277 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698965003278 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 698965003279 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 698965003280 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 698965003281 CoenzymeA binding site [chemical binding]; other site 698965003282 subunit interaction site [polypeptide binding]; other site 698965003283 PHB binding site; other site 698965003284 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 698965003285 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 698965003286 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 698965003287 oligomer interface [polypeptide binding]; other site 698965003288 metal binding site [ion binding]; metal-binding site 698965003289 metal binding site [ion binding]; metal-binding site 698965003290 putative Cl binding site [ion binding]; other site 698965003291 basic sphincter; other site 698965003292 hydrophobic gate; other site 698965003293 periplasmic entrance; other site 698965003294 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698965003295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698965003296 S-adenosylmethionine binding site [chemical binding]; other site 698965003297 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698965003298 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698965003299 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698965003300 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 698965003301 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698965003302 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 698965003303 potential frameshift: common BLAST hit: gi|227833113|ref|YP_002834820.1| oxidoreductase 698965003304 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698965003305 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698965003306 FAD binding domain; Region: FAD_binding_4; pfam01565 698965003307 potential frameshift: common BLAST hit: gi|38233809|ref|NP_939576.1| sodium-dependent transport membrane protein 698965003308 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698965003309 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698965003310 Sodium Bile acid symporter family; Region: SBF; cl17470 698965003311 YceI-like domain; Region: YceI; pfam04264 698965003312 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 698965003313 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 698965003314 Ligand binding site; other site 698965003315 Putative Catalytic site; other site 698965003316 DXD motif; other site 698965003317 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 698965003318 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 698965003319 putative active site [active] 698965003320 catalytic triad [active] 698965003321 putative dimer interface [polypeptide binding]; other site 698965003322 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 698965003323 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 698965003324 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698965003325 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698965003326 precorrin-3B synthase; Region: CobG; TIGR02435 698965003327 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698965003328 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698965003329 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 698965003330 Precorrin-8X methylmutase; Region: CbiC; pfam02570 698965003331 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 698965003332 active site 698965003333 SAM binding site [chemical binding]; other site 698965003334 homodimer interface [polypeptide binding]; other site 698965003335 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 698965003336 active site 698965003337 SAM binding site [chemical binding]; other site 698965003338 homodimer interface [polypeptide binding]; other site 698965003339 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 698965003340 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 698965003341 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 698965003342 active site 698965003343 SAM binding site [chemical binding]; other site 698965003344 homodimer interface [polypeptide binding]; other site 698965003345 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 698965003346 active site 698965003347 putative homodimer interface [polypeptide binding]; other site 698965003348 SAM binding site [chemical binding]; other site 698965003349 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 698965003350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698965003351 S-adenosylmethionine binding site [chemical binding]; other site 698965003352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698965003353 short chain dehydrogenase; Provisional; Region: PRK08251 698965003354 NAD(P) binding site [chemical binding]; other site 698965003355 active site 698965003356 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698965003357 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698965003358 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698965003359 active site 698965003360 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698965003361 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698965003362 ATP binding site [chemical binding]; other site 698965003363 putative Mg++ binding site [ion binding]; other site 698965003364 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698965003365 nucleotide binding region [chemical binding]; other site 698965003366 ATP-binding site [chemical binding]; other site 698965003367 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 698965003368 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 698965003369 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 698965003370 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 698965003371 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 698965003372 Predicted transcriptional regulator [Transcription]; Region: COG2378 698965003373 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 698965003374 WYL domain; Region: WYL; pfam13280 698965003375 WYL domain; Region: WYL; pfam13280 698965003376 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 698965003377 Pup-like protein; Region: Pup; pfam05639 698965003378 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 698965003379 proteasome ATPase; Region: pup_AAA; TIGR03689 698965003380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698965003381 Walker A motif; other site 698965003382 ATP binding site [chemical binding]; other site 698965003383 Walker B motif; other site 698965003384 arginine finger; other site 698965003385 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 698965003386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698965003387 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 698965003388 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 698965003389 active site 698965003390 metal binding site [ion binding]; metal-binding site 698965003391 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 698965003392 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 698965003393 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 698965003394 Potassium binding sites [ion binding]; other site 698965003395 Cesium cation binding sites [ion binding]; other site 698965003396 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 698965003397 Aspartase; Region: Aspartase; cd01357 698965003398 active sites [active] 698965003399 tetramer interface [polypeptide binding]; other site 698965003400 potential frameshift: common BLAST hit: gi|38233843|ref|NP_939610.1| anaerobic C4-dicarboxylate transporter 698965003401 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 698965003402 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 698965003403 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 698965003404 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 698965003405 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 698965003406 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 698965003407 homodimer interface [polypeptide binding]; other site 698965003408 putative metal binding site [ion binding]; other site 698965003409 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 698965003410 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698965003411 motif II; other site 698965003412 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 698965003413 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 698965003414 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 698965003415 substrate binding pocket [chemical binding]; other site 698965003416 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 698965003417 B12 binding site [chemical binding]; other site 698965003418 cobalt ligand [ion binding]; other site 698965003419 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 698965003420 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 698965003421 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698965003422 active site 698965003423 HIGH motif; other site 698965003424 nucleotide binding site [chemical binding]; other site 698965003425 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698965003426 active site 698965003427 KMSKS motif; other site 698965003428 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698965003429 tRNA binding surface [nucleotide binding]; other site 698965003430 anticodon binding site; other site 698965003431 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 698965003432 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 698965003433 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 698965003434 quinone interaction residues [chemical binding]; other site 698965003435 active site 698965003436 catalytic residues [active] 698965003437 FMN binding site [chemical binding]; other site 698965003438 substrate binding site [chemical binding]; other site 698965003439 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 698965003440 substrate binding site [chemical binding]; other site 698965003441 potential frameshift: common BLAST hit: gi|172041171|ref|YP_001800885.1| transposase for insertion sequence 698965003442 MULE transposase domain; Region: MULE; pfam10551 698965003443 potential frameshift: common BLAST hit: gi|38233440|ref|NP_939207.1| transposase 698965003444 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698965003445 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698965003446 HTH-like domain; Region: HTH_21; pfam13276 698965003447 Integrase core domain; Region: rve; pfam00665 698965003448 Integrase core domain; Region: rve_2; pfam13333 698965003449 potential frameshift: common BLAST hit: gi|256379310|ref|YP_003102970.1| oxidoreductase 698965003450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698965003451 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698965003452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698965003453 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698965003454 active site residue [active] 698965003455 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698965003456 active site residue [active] 698965003457 membrane ATPase/protein kinase; Provisional; Region: PRK09435 698965003458 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 698965003459 Walker A; other site 698965003460 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 698965003461 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 698965003462 active site 698965003463 substrate binding site [chemical binding]; other site 698965003464 coenzyme B12 binding site [chemical binding]; other site 698965003465 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 698965003466 B12 binding site [chemical binding]; other site 698965003467 cobalt ligand [ion binding]; other site 698965003468 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 698965003469 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 698965003470 heterodimer interface [polypeptide binding]; other site 698965003471 substrate interaction site [chemical binding]; other site 698965003472 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 698965003473 Uncharacterized conserved protein [Function unknown]; Region: COG0398 698965003474 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 698965003475 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698965003476 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 698965003477 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 698965003478 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 698965003479 ferrochelatase; Reviewed; Region: hemH; PRK00035 698965003480 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 698965003481 C-terminal domain interface [polypeptide binding]; other site 698965003482 active site 698965003483 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 698965003484 active site 698965003485 N-terminal domain interface [polypeptide binding]; other site 698965003486 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698965003487 NlpC/P60 family; Region: NLPC_P60; pfam00877 698965003488 aconitate hydratase; Validated; Region: PRK09277 698965003489 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698965003490 substrate binding site [chemical binding]; other site 698965003491 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698965003492 ligand binding site [chemical binding]; other site 698965003493 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 698965003494 substrate binding site [chemical binding]; other site 698965003495 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698965003496 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698965003497 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 698965003498 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 698965003499 catalytic triad [active] 698965003500 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 698965003501 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 698965003502 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698965003503 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698965003504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965003505 Walker A/P-loop; other site 698965003506 ATP binding site [chemical binding]; other site 698965003507 Q-loop/lid; other site 698965003508 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698965003509 ABC transporter signature motif; other site 698965003510 Walker B; other site 698965003511 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698965003512 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 698965003513 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 698965003514 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 698965003515 trimerization site [polypeptide binding]; other site 698965003516 active site 698965003517 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698965003518 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 698965003519 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698965003520 catalytic residue [active] 698965003521 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 698965003522 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 698965003523 Walker A/P-loop; other site 698965003524 ATP binding site [chemical binding]; other site 698965003525 Q-loop/lid; other site 698965003526 ABC transporter signature motif; other site 698965003527 Walker B; other site 698965003528 D-loop; other site 698965003529 H-loop/switch region; other site 698965003530 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 698965003531 FeS assembly protein SufD; Region: sufD; TIGR01981 698965003532 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 698965003533 FeS assembly protein SufB; Region: sufB; TIGR01980 698965003534 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698965003535 Predicted transcriptional regulator [Transcription]; Region: COG2345 698965003536 putative DNA binding site [nucleotide binding]; other site 698965003537 putative Zn2+ binding site [ion binding]; other site 698965003538 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698965003539 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698965003540 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698965003541 Walker A/P-loop; other site 698965003542 ATP binding site [chemical binding]; other site 698965003543 Q-loop/lid; other site 698965003544 ABC transporter signature motif; other site 698965003545 Walker B; other site 698965003546 D-loop; other site 698965003547 H-loop/switch region; other site 698965003548 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698965003549 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698965003550 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 698965003551 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 698965003552 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 698965003553 UbiA prenyltransferase family; Region: UbiA; pfam01040 698965003554 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 698965003555 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 698965003556 TPP-binding site [chemical binding]; other site 698965003557 dimer interface [polypeptide binding]; other site 698965003558 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698965003559 PYR/PP interface [polypeptide binding]; other site 698965003560 dimer interface [polypeptide binding]; other site 698965003561 TPP binding site [chemical binding]; other site 698965003562 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 698965003563 putative active site [active] 698965003564 transaldolase; Provisional; Region: PRK03903 698965003565 catalytic residue [active] 698965003566 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 698965003567 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 698965003568 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 698965003569 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 698965003570 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 698965003571 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698965003572 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 698965003573 putative active site [active] 698965003574 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 698965003575 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 698965003576 triosephosphate isomerase; Provisional; Region: PRK14567 698965003577 substrate binding site [chemical binding]; other site 698965003578 dimer interface [polypeptide binding]; other site 698965003579 catalytic triad [active] 698965003580 Phosphoglycerate kinase; Region: PGK; pfam00162 698965003581 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 698965003582 substrate binding site [chemical binding]; other site 698965003583 hinge regions; other site 698965003584 ADP binding site [chemical binding]; other site 698965003585 catalytic site [active] 698965003586 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 698965003587 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 698965003588 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698965003589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 698965003590 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 698965003591 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 698965003592 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 698965003593 phosphate binding site [ion binding]; other site 698965003594 putative substrate binding pocket [chemical binding]; other site 698965003595 dimer interface [polypeptide binding]; other site 698965003596 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 698965003597 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 698965003598 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 698965003599 GIY-YIG motif/motif A; other site 698965003600 active site 698965003601 catalytic site [active] 698965003602 putative DNA binding site [nucleotide binding]; other site 698965003603 metal binding site [ion binding]; metal-binding site 698965003604 UvrB/uvrC motif; Region: UVR; pfam02151 698965003605 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 698965003606 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698965003607 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 698965003608 homopentamer interface [polypeptide binding]; other site 698965003609 active site 698965003610 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 698965003611 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 698965003612 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 698965003613 dimerization interface [polypeptide binding]; other site 698965003614 active site 698965003615 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 698965003616 Lumazine binding domain; Region: Lum_binding; pfam00677 698965003617 Lumazine binding domain; Region: Lum_binding; pfam00677 698965003618 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 698965003619 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 698965003620 catalytic motif [active] 698965003621 Zn binding site [ion binding]; other site 698965003622 RibD C-terminal domain; Region: RibD_C; pfam01872 698965003623 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 698965003624 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 698965003625 substrate binding site [chemical binding]; other site 698965003626 hexamer interface [polypeptide binding]; other site 698965003627 metal binding site [ion binding]; metal-binding site 698965003628 16S rRNA methyltransferase B; Provisional; Region: PRK14902 698965003629 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 698965003630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698965003631 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 698965003632 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 698965003633 putative active site [active] 698965003634 substrate binding site [chemical binding]; other site 698965003635 putative cosubstrate binding site; other site 698965003636 catalytic site [active] 698965003637 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 698965003638 substrate binding site [chemical binding]; other site 698965003639 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698965003640 active site 698965003641 catalytic residues [active] 698965003642 metal binding site [ion binding]; metal-binding site 698965003643 primosome assembly protein PriA; Provisional; Region: PRK14873 698965003644 S-adenosylmethionine synthetase; Validated; Region: PRK05250 698965003645 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 698965003646 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 698965003647 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 698965003648 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 698965003649 Flavoprotein; Region: Flavoprotein; pfam02441 698965003650 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 698965003651 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 698965003652 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 698965003653 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 698965003654 catalytic site [active] 698965003655 G-X2-G-X-G-K; other site 698965003656 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 698965003657 active site 698965003658 dimer interface [polypeptide binding]; other site 698965003659 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 698965003660 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698965003661 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698965003662 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 698965003663 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698965003664 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698965003665 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 698965003666 IMP binding site; other site 698965003667 dimer interface [polypeptide binding]; other site 698965003668 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 698965003669 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 698965003670 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 698965003671 catalytic site [active] 698965003672 subunit interface [polypeptide binding]; other site 698965003673 dihydroorotase; Validated; Region: pyrC; PRK09357 698965003674 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698965003675 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 698965003676 active site 698965003677 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 698965003678 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698965003679 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698965003680 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 698965003681 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698965003682 active site 698965003683 hydrophobic ligand binding site; other site 698965003684 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698965003685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698965003686 TIGR01777 family protein; Region: yfcH 698965003687 NAD(P) binding site [chemical binding]; other site 698965003688 active site 698965003689 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 698965003690 elongation factor P; Validated; Region: PRK00529 698965003691 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 698965003692 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 698965003693 RNA binding site [nucleotide binding]; other site 698965003694 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 698965003695 RNA binding site [nucleotide binding]; other site 698965003696 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698965003697 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698965003698 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698965003699 active site 698965003700 Dehydroquinase class II; Region: DHquinase_II; pfam01220 698965003701 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 698965003702 trimer interface [polypeptide binding]; other site 698965003703 active site 698965003704 dimer interface [polypeptide binding]; other site 698965003705 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 698965003706 active site 698965003707 dimer interface [polypeptide binding]; other site 698965003708 metal binding site [ion binding]; metal-binding site 698965003709 shikimate kinase; Reviewed; Region: aroK; PRK00131 698965003710 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 698965003711 ADP binding site [chemical binding]; other site 698965003712 magnesium binding site [ion binding]; other site 698965003713 putative shikimate binding site; other site 698965003714 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 698965003715 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 698965003716 Tetramer interface [polypeptide binding]; other site 698965003717 active site 698965003718 FMN-binding site [chemical binding]; other site 698965003719 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 698965003720 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698965003721 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698965003722 shikimate binding site; other site 698965003723 NAD(P) binding site [chemical binding]; other site 698965003724 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 698965003725 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 698965003726 dimerization interface [polypeptide binding]; other site 698965003727 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 698965003728 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 698965003729 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 698965003730 motif 1; other site 698965003731 active site 698965003732 motif 2; other site 698965003733 motif 3; other site 698965003734 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698965003735 DHHA1 domain; Region: DHHA1; pfam02272 698965003736 recombination factor protein RarA; Reviewed; Region: PRK13342 698965003737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698965003738 Walker A motif; other site 698965003739 ATP binding site [chemical binding]; other site 698965003740 Walker B motif; other site 698965003741 arginine finger; other site 698965003742 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 698965003743 Phosphotransferase enzyme family; Region: APH; pfam01636 698965003744 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698965003745 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 698965003746 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 698965003747 dimer interface [polypeptide binding]; other site 698965003748 anticodon binding site; other site 698965003749 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 698965003750 homodimer interface [polypeptide binding]; other site 698965003751 motif 1; other site 698965003752 active site 698965003753 motif 2; other site 698965003754 GAD domain; Region: GAD; pfam02938 698965003755 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698965003756 active site 698965003757 motif 3; other site 698965003758 Predicted metalloprotease [General function prediction only]; Region: COG2321 698965003759 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 698965003760 potential frameshift: common BLAST hit: gi|62390520|ref|YP_225922.1| SNF2 family DNA/RNA helicase 698965003761 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698965003762 ATP binding site [chemical binding]; other site 698965003763 putative Mg++ binding site [ion binding]; other site 698965003764 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698965003765 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 698965003766 nucleotide binding region [chemical binding]; other site 698965003767 ATP-binding site [chemical binding]; other site 698965003768 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 698965003769 Predicted membrane protein [Function unknown]; Region: COG1511 698965003770 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698965003771 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698965003772 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698965003773 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698965003774 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698965003775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965003776 Q-loop/lid; other site 698965003777 ABC transporter signature motif; other site 698965003778 Walker B; other site 698965003779 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698965003780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698965003781 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698965003782 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698965003783 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698965003784 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 698965003785 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 698965003786 dimer interface [polypeptide binding]; other site 698965003787 motif 1; other site 698965003788 active site 698965003789 motif 2; other site 698965003790 motif 3; other site 698965003791 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 698965003792 anticodon binding site; other site 698965003793 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698965003794 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 698965003795 dimer interface [polypeptide binding]; other site 698965003796 catalytic triad [active] 698965003797 peroxidatic and resolving cysteines [active] 698965003798 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698965003799 active site 698965003800 MULE transposase domain; Region: MULE; pfam10551 698965003801 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698965003802 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698965003803 Zn2+ binding site [ion binding]; other site 698965003804 Mg2+ binding site [ion binding]; other site 698965003805 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698965003806 synthetase active site [active] 698965003807 NTP binding site [chemical binding]; other site 698965003808 metal binding site [ion binding]; metal-binding site 698965003809 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 698965003810 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 698965003811 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698965003812 active site 698965003813 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 698965003814 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698965003815 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 698965003816 Protein export membrane protein; Region: SecD_SecF; cl14618 698965003817 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 698965003818 Protein export membrane protein; Region: SecD_SecF; cl14618 698965003819 Preprotein translocase subunit; Region: YajC; pfam02699 698965003820 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 698965003821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698965003822 Walker A motif; other site 698965003823 ATP binding site [chemical binding]; other site 698965003824 Walker B motif; other site 698965003825 arginine finger; other site 698965003826 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 698965003827 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 698965003828 RuvA N terminal domain; Region: RuvA_N; pfam01330 698965003829 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 698965003830 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 698965003831 active site 698965003832 putative DNA-binding cleft [nucleotide binding]; other site 698965003833 dimer interface [polypeptide binding]; other site 698965003834 hypothetical protein; Validated; Region: PRK00110 698965003835 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 698965003836 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 698965003837 active site 698965003838 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 698965003839 catalytic triad [active] 698965003840 dimer interface [polypeptide binding]; other site 698965003841 HTH-like domain; Region: HTH_21; pfam13276 698965003842 potential frameshift: common BLAST hit: gi|68536858|ref|YP_251563.1| transposase IS3504k 698965003843 Integrase core domain; Region: rve; pfam00665 698965003844 Integrase core domain; Region: rve; pfam00665 698965003845 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 698965003846 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 698965003847 Nitronate monooxygenase; Region: NMO; pfam03060 698965003848 FMN binding site [chemical binding]; other site 698965003849 substrate binding site [chemical binding]; other site 698965003850 putative catalytic residue [active] 698965003851 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 698965003852 Replicase family; Region: Replicase; pfam03090 698965003853 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698965003854 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698965003855 catalytic residues [active] 698965003856 catalytic nucleophile [active] 698965003857 Presynaptic Site I dimer interface [polypeptide binding]; other site 698965003858 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698965003859 Synaptic Flat tetramer interface [polypeptide binding]; other site 698965003860 Synaptic Site I dimer interface [polypeptide binding]; other site 698965003861 DNA binding site [nucleotide binding] 698965003862 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698965003863 potential frameshift: common BLAST hit: gi|68536874|ref|YP_251579.1| transposase IS3525 698965003864 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698965003865 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698965003866 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698965003867 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 698965003868 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 698965003869 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698965003870 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698965003871 catalytic residue [active] 698965003872 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698965003873 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698965003874 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 698965003875 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 698965003876 putative acyl-acceptor binding pocket; other site 698965003877 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698965003878 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 698965003879 nucleotide binding site/active site [active] 698965003880 HIT family signature motif; other site 698965003881 catalytic residue [active] 698965003882 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 698965003883 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698965003884 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 698965003885 active site 698965003886 dimer interface [polypeptide binding]; other site 698965003887 motif 1; other site 698965003888 motif 2; other site 698965003889 motif 3; other site 698965003890 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 698965003891 anticodon binding site; other site 698965003892 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 698965003893 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 698965003894 Protein of unknown function (DUF461); Region: DUF461; pfam04314 698965003895 CopC domain; Region: CopC; cl01012 698965003896 putative transposase OrfB; Reviewed; Region: PHA02517 698965003897 hypothetical protein; Provisional; Region: PRK14059 698965003898 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 698965003899 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 698965003900 SelR domain; Region: SelR; pfam01641 698965003901 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 698965003902 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 698965003903 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 698965003904 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 698965003905 catalytic site [active] 698965003906 putative active site [active] 698965003907 putative substrate binding site [chemical binding]; other site 698965003908 HRDC domain; Region: HRDC; pfam00570 698965003909 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 698965003910 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 698965003911 TPP-binding site; other site 698965003912 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698965003913 PYR/PP interface [polypeptide binding]; other site 698965003914 dimer interface [polypeptide binding]; other site 698965003915 TPP binding site [chemical binding]; other site 698965003916 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698965003917 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 698965003918 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 698965003919 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 698965003920 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698965003921 trimer interface [polypeptide binding]; other site 698965003922 active site 698965003923 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 698965003924 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 698965003925 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698965003926 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 698965003927 active site 698965003928 dimerization interface [polypeptide binding]; other site 698965003929 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698965003930 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698965003931 nucleotide binding site [chemical binding]; other site 698965003932 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698965003933 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698965003934 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698965003935 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698965003936 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698965003937 DNA binding residues [nucleotide binding] 698965003938 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698965003939 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698965003940 ATP binding site [chemical binding]; other site 698965003941 putative Mg++ binding site [ion binding]; other site 698965003942 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 698965003943 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 698965003944 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 698965003945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698965003946 S-adenosylmethionine binding site [chemical binding]; other site 698965003947 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 698965003948 putative active site [active] 698965003949 dimerization interface [polypeptide binding]; other site 698965003950 putative tRNAtyr binding site [nucleotide binding]; other site 698965003951 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698965003952 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698965003953 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698965003954 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698965003955 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698965003956 DNA binding residues [nucleotide binding] 698965003957 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698965003958 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698965003959 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698965003960 FeoA domain; Region: FeoA; cl00838 698965003961 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 698965003962 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 698965003963 NAD binding site [chemical binding]; other site 698965003964 homodimer interface [polypeptide binding]; other site 698965003965 active site 698965003966 substrate binding site [chemical binding]; other site 698965003967 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 698965003968 PAC2 family; Region: PAC2; pfam09754 698965003969 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698965003970 ATP binding site [chemical binding]; other site 698965003971 putative Mg++ binding site [ion binding]; other site 698965003972 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698965003973 nucleotide binding region [chemical binding]; other site 698965003974 ATP-binding site [chemical binding]; other site 698965003975 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 698965003976 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 698965003977 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 698965003978 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698965003979 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 698965003980 dimer interface [polypeptide binding]; other site 698965003981 decamer (pentamer of dimers) interface [polypeptide binding]; other site 698965003982 catalytic triad [active] 698965003983 peroxidatic and resolving cysteines [active] 698965003984 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698965003985 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 698965003986 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 698965003987 dimerization interface [polypeptide binding]; other site 698965003988 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 698965003989 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698965003990 ATP binding site [chemical binding]; other site 698965003991 putative Mg++ binding site [ion binding]; other site 698965003992 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698965003993 nucleotide binding region [chemical binding]; other site 698965003994 ATP-binding site [chemical binding]; other site 698965003995 Helicase associated domain (HA2); Region: HA2; pfam04408 698965003996 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 698965003997 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 698965003998 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 698965003999 ATP cone domain; Region: ATP-cone; pfam03477 698965004000 LexA repressor; Validated; Region: PRK00215 698965004001 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 698965004002 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698965004003 Catalytic site [active] 698965004004 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698965004005 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 698965004006 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698965004007 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 698965004008 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 698965004009 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 698965004010 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 698965004011 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698965004012 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698965004013 DNA-binding site [nucleotide binding]; DNA binding site 698965004014 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698965004015 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 698965004016 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 698965004017 putative substrate binding site [chemical binding]; other site 698965004018 putative ATP binding site [chemical binding]; other site 698965004019 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698965004020 dimerization domain swap beta strand [polypeptide binding]; other site 698965004021 regulatory protein interface [polypeptide binding]; other site 698965004022 active site 698965004023 regulatory phosphorylation site [posttranslational modification]; other site 698965004024 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 698965004025 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698965004026 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 698965004027 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698965004028 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 698965004029 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 698965004030 GTPases [General function prediction only]; Region: HflX; COG2262 698965004031 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 698965004032 HflX GTPase family; Region: HflX; cd01878 698965004033 G1 box; other site 698965004034 GTP/Mg2+ binding site [chemical binding]; other site 698965004035 Switch I region; other site 698965004036 G2 box; other site 698965004037 G3 box; other site 698965004038 Switch II region; other site 698965004039 G4 box; other site 698965004040 G5 box; other site 698965004041 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 698965004042 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698965004043 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698965004044 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 698965004045 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 698965004046 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698965004047 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698965004048 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698965004049 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 698965004050 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 698965004051 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698965004052 FeS/SAM binding site; other site 698965004053 recombination regulator RecX; Reviewed; Region: recX; PRK00117 698965004054 recombinase A; Provisional; Region: recA; PRK09354 698965004055 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 698965004056 hexamer interface [polypeptide binding]; other site 698965004057 Walker A motif; other site 698965004058 ATP binding site [chemical binding]; other site 698965004059 Walker B motif; other site 698965004060 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 698965004061 BioY family; Region: BioY; pfam02632 698965004062 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698965004063 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698965004064 Walker A/P-loop; other site 698965004065 ATP binding site [chemical binding]; other site 698965004066 Q-loop/lid; other site 698965004067 ABC transporter signature motif; other site 698965004068 Walker B; other site 698965004069 D-loop; other site 698965004070 H-loop/switch region; other site 698965004071 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698965004072 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698965004073 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698965004074 sequence-specific DNA binding site [nucleotide binding]; other site 698965004075 salt bridge; other site 698965004076 Competence-damaged protein; Region: CinA; pfam02464 698965004077 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698965004078 YCII-related domain; Region: YCII; cl00999 698965004079 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 698965004080 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 698965004081 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698965004082 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 698965004083 TIGR03085 family protein; Region: TIGR03085 698965004084 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 698965004085 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698965004086 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 698965004087 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 698965004088 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698965004089 dimer interface [polypeptide binding]; other site 698965004090 active site 698965004091 catalytic residue [active] 698965004092 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 698965004093 dihydrodipicolinate reductase; Provisional; Region: PRK00048 698965004094 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 698965004095 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 698965004096 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 698965004097 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 698965004098 oligomer interface [polypeptide binding]; other site 698965004099 RNA binding site [nucleotide binding]; other site 698965004100 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 698965004101 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 698965004102 RNase E interface [polypeptide binding]; other site 698965004103 trimer interface [polypeptide binding]; other site 698965004104 active site 698965004105 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 698965004106 putative nucleic acid binding region [nucleotide binding]; other site 698965004107 G-X-X-G motif; other site 698965004108 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 698965004109 RNA binding site [nucleotide binding]; other site 698965004110 domain interface; other site 698965004111 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 698965004112 16S/18S rRNA binding site [nucleotide binding]; other site 698965004113 S13e-L30e interaction site [polypeptide binding]; other site 698965004114 25S rRNA binding site [nucleotide binding]; other site 698965004115 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 698965004116 active site 698965004117 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 698965004118 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 698965004119 active site 698965004120 Riboflavin kinase; Region: Flavokinase; smart00904 698965004121 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 698965004122 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 698965004123 RNA binding site [nucleotide binding]; other site 698965004124 active site 698965004125 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 698965004126 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 698965004127 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 698965004128 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698965004129 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698965004130 active site 698965004131 metal binding site [ion binding]; metal-binding site 698965004132 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698965004133 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 698965004134 potential frameshift: common BLAST hit: gi|25028432|ref|NP_738486.1| exopolyphosphatase 698965004135 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 698965004136 DHH family; Region: DHH; pfam01368 698965004137 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 698965004138 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698965004139 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698965004140 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 698965004141 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 698965004142 G1 box; other site 698965004143 putative GEF interaction site [polypeptide binding]; other site 698965004144 GTP/Mg2+ binding site [chemical binding]; other site 698965004145 Switch I region; other site 698965004146 G2 box; other site 698965004147 G3 box; other site 698965004148 Switch II region; other site 698965004149 G4 box; other site 698965004150 G5 box; other site 698965004151 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 698965004152 Translation-initiation factor 2; Region: IF-2; pfam11987 698965004153 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 698965004154 Protein of unknown function (DUF448); Region: DUF448; pfam04296 698965004155 putative RNA binding cleft [nucleotide binding]; other site 698965004156 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 698965004157 NusA N-terminal domain; Region: NusA_N; pfam08529 698965004158 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 698965004159 RNA binding site [nucleotide binding]; other site 698965004160 homodimer interface [polypeptide binding]; other site 698965004161 NusA-like KH domain; Region: KH_5; pfam13184 698965004162 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 698965004163 G-X-X-G motif; other site 698965004164 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 698965004165 Sm and related proteins; Region: Sm_like; cl00259 698965004166 prolyl-tRNA synthetase; Provisional; Region: PRK09194 698965004167 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 698965004168 dimer interface [polypeptide binding]; other site 698965004169 motif 1; other site 698965004170 active site 698965004171 motif 2; other site 698965004172 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 698965004173 putative deacylase active site [active] 698965004174 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698965004175 active site 698965004176 motif 3; other site 698965004177 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 698965004178 anticodon binding site; other site 698965004179 hypothetical protein; Validated; Region: PRK02101 698965004180 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 698965004181 active site 698965004182 SAM binding site [chemical binding]; other site 698965004183 homodimer interface [polypeptide binding]; other site 698965004184 Uncharacterized conserved protein [Function unknown]; Region: COG0397 698965004185 hypothetical protein; Validated; Region: PRK00029 698965004186 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698965004187 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 698965004188 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 698965004189 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 698965004190 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698965004191 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 698965004192 catalytic triad [active] 698965004193 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 698965004194 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 698965004195 Walker A motif; other site 698965004196 homodimer interface [polypeptide binding]; other site 698965004197 ATP binding site [chemical binding]; other site 698965004198 hydroxycobalamin binding site [chemical binding]; other site 698965004199 Walker B motif; other site 698965004200 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 698965004201 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 698965004202 metal ion-dependent adhesion site (MIDAS); other site 698965004203 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 698965004204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698965004205 Walker A motif; other site 698965004206 ATP binding site [chemical binding]; other site 698965004207 Walker B motif; other site 698965004208 arginine finger; other site 698965004209 malate:quinone oxidoreductase; Validated; Region: PRK05257 698965004210 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 698965004211 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698965004212 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698965004213 mycothione reductase; Region: mycothione_red; TIGR03452 698965004214 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698965004215 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698965004216 cobyric acid synthase; Provisional; Region: PRK00784 698965004217 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 698965004218 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698965004219 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698965004220 catalytic triad [active] 698965004221 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698965004222 active site 698965004223 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 698965004224 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698965004225 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 698965004226 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698965004227 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698965004228 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 698965004229 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698965004230 active site 698965004231 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 698965004232 protein binding site [polypeptide binding]; other site 698965004233 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 698965004234 putative substrate binding region [chemical binding]; other site 698965004235 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 698965004236 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 698965004237 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 698965004238 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 698965004239 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 698965004240 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 698965004241 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698965004242 FeS/SAM binding site; other site 698965004243 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 698965004244 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 698965004245 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 698965004246 ribosome recycling factor; Reviewed; Region: frr; PRK00083 698965004247 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 698965004248 hinge region; other site 698965004249 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 698965004250 putative nucleotide binding site [chemical binding]; other site 698965004251 uridine monophosphate binding site [chemical binding]; other site 698965004252 homohexameric interface [polypeptide binding]; other site 698965004253 elongation factor Ts; Provisional; Region: tsf; PRK09377 698965004254 UBA/TS-N domain; Region: UBA; pfam00627 698965004255 Elongation factor TS; Region: EF_TS; pfam00889 698965004256 Elongation factor TS; Region: EF_TS; pfam00889 698965004257 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 698965004258 rRNA interaction site [nucleotide binding]; other site 698965004259 S8 interaction site; other site 698965004260 putative laminin-1 binding site; other site 698965004261 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698965004262 Peptidase family M23; Region: Peptidase_M23; pfam01551 698965004263 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698965004264 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 698965004265 active site 698965004266 DNA binding site [nucleotide binding] 698965004267 Int/Topo IB signature motif; other site 698965004268 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 698965004269 DNA protecting protein DprA; Region: dprA; TIGR00732 698965004270 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 698965004271 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698965004272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698965004273 Walker A motif; other site 698965004274 ATP binding site [chemical binding]; other site 698965004275 Walker B motif; other site 698965004276 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 698965004277 hypothetical protein; Reviewed; Region: PRK12497 698965004278 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 698965004279 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 698965004280 RNA/DNA hybrid binding site [nucleotide binding]; other site 698965004281 active site 698965004282 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 698965004283 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698965004284 Catalytic site [active] 698965004285 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698965004286 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 698965004287 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 698965004288 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 698965004289 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 698965004290 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698965004291 RNA binding site [nucleotide binding]; other site 698965004292 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 698965004293 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 698965004294 RimM N-terminal domain; Region: RimM; pfam01782 698965004295 PRC-barrel domain; Region: PRC; pfam05239 698965004296 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 698965004297 signal recognition particle protein; Provisional; Region: PRK10867 698965004298 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 698965004299 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 698965004300 P loop; other site 698965004301 GTP binding site [chemical binding]; other site 698965004302 Signal peptide binding domain; Region: SRP_SPB; pfam02978 698965004303 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 698965004304 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698965004305 metal binding triad; other site 698965004306 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698965004307 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 698965004308 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 698965004309 Nitrogen regulatory protein P-II; Region: P-II; smart00938 698965004310 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 698965004311 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 698965004312 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 698965004313 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698965004314 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 698965004315 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698965004316 Walker A/P-loop; other site 698965004317 ATP binding site [chemical binding]; other site 698965004318 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 698965004319 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698965004320 ABC transporter signature motif; other site 698965004321 Walker B; other site 698965004322 D-loop; other site 698965004323 H-loop/switch region; other site 698965004324 Acylphosphatase; Region: Acylphosphatase; cl00551 698965004325 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698965004326 amino acid carrier protein; Region: agcS; TIGR00835 698965004327 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 698965004328 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 698965004329 DNA binding site [nucleotide binding] 698965004330 catalytic residue [active] 698965004331 H2TH interface [polypeptide binding]; other site 698965004332 putative catalytic residues [active] 698965004333 turnover-facilitating residue; other site 698965004334 intercalation triad [nucleotide binding]; other site 698965004335 8OG recognition residue [nucleotide binding]; other site 698965004336 putative reading head residues; other site 698965004337 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698965004338 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698965004339 ribonuclease III; Reviewed; Region: rnc; PRK00102 698965004340 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 698965004341 dimerization interface [polypeptide binding]; other site 698965004342 active site 698965004343 metal binding site [ion binding]; metal-binding site 698965004344 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 698965004345 dsRNA binding site [nucleotide binding]; other site 698965004346 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 698965004347 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698965004348 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 698965004349 glutamate dehydrogenase; Provisional; Region: PRK09414 698965004350 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 698965004351 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 698965004352 NAD(P) binding site [chemical binding]; other site 698965004353 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 698965004354 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698965004355 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698965004356 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 698965004357 metal binding site [ion binding]; metal-binding site 698965004358 putative dimer interface [polypeptide binding]; other site 698965004359 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 698965004360 homodimer interface [polypeptide binding]; other site 698965004361 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 698965004362 active site pocket [active] 698965004363 pyruvate kinase; Provisional; Region: PRK06247 698965004364 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 698965004365 domain interfaces; other site 698965004366 active site 698965004367 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 698965004368 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698965004369 active site 698965004370 ribulose/triose binding site [chemical binding]; other site 698965004371 phosphate binding site [ion binding]; other site 698965004372 substrate (anthranilate) binding pocket [chemical binding]; other site 698965004373 product (indole) binding pocket [chemical binding]; other site 698965004374 trp region conserved hypothetical membrane protein; Region: trp_oprn_chp; TIGR02234 698965004375 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 698965004376 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 698965004377 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698965004378 substrate binding site [chemical binding]; other site 698965004379 glutamase interaction surface [polypeptide binding]; other site 698965004380 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698965004381 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698965004382 active site 698965004383 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 698965004384 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698965004385 catalytic residues [active] 698965004386 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 698965004387 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 698965004388 putative active site [active] 698965004389 oxyanion strand; other site 698965004390 catalytic triad [active] 698965004391 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698965004392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965004393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965004394 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 698965004395 putative active site pocket [active] 698965004396 4-fold oligomerization interface [polypeptide binding]; other site 698965004397 metal binding residues [ion binding]; metal-binding site 698965004398 3-fold/trimer interface [polypeptide binding]; other site 698965004399 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 698965004400 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698965004401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698965004402 homodimer interface [polypeptide binding]; other site 698965004403 catalytic residue [active] 698965004404 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 698965004405 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 698965004406 NAD binding site [chemical binding]; other site 698965004407 dimerization interface [polypeptide binding]; other site 698965004408 product binding site; other site 698965004409 substrate binding site [chemical binding]; other site 698965004410 zinc binding site [ion binding]; other site 698965004411 catalytic residues [active] 698965004412 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 698965004413 tetracycline repressor protein TetR; Provisional; Region: PRK13756 698965004414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698965004415 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 698965004416 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 698965004417 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 698965004418 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 698965004419 active site 698965004420 catalytic site [active] 698965004421 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 698965004422 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 698965004423 active site 698965004424 catalytic site [active] 698965004425 substrate binding site [chemical binding]; other site 698965004426 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698965004427 synthetase active site [active] 698965004428 NTP binding site [chemical binding]; other site 698965004429 metal binding site [ion binding]; metal-binding site 698965004430 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698965004431 RNA binding surface [nucleotide binding]; other site 698965004432 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 698965004433 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 698965004434 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 698965004435 threonine dehydratase; Validated; Region: PRK08639 698965004436 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698965004437 tetramer interface [polypeptide binding]; other site 698965004438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698965004439 catalytic residue [active] 698965004440 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 698965004441 putative Ile/Val binding site [chemical binding]; other site 698965004442 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 698965004443 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 698965004444 active site 698965004445 PHP Thumb interface [polypeptide binding]; other site 698965004446 metal binding site [ion binding]; metal-binding site 698965004447 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698965004448 generic binding surface II; other site 698965004449 generic binding surface I; other site 698965004450 Predicted permeases [General function prediction only]; Region: RarD; COG2962 698965004451 EamA-like transporter family; Region: EamA; cl17759 698965004452 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 698965004453 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698965004454 RNA binding surface [nucleotide binding]; other site 698965004455 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698965004456 active site 698965004457 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 698965004458 lipoprotein signal peptidase; Provisional; Region: PRK14787 698965004459 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698965004460 active site 698965004461 homotetramer interface [polypeptide binding]; other site 698965004462 homodimer interface [polypeptide binding]; other site 698965004463 DNA polymerase IV; Provisional; Region: PRK03348 698965004464 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 698965004465 active site 698965004466 DNA binding site [nucleotide binding] 698965004467 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 698965004468 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698965004469 HIGH motif; other site 698965004470 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698965004471 active site 698965004472 KMSKS motif; other site 698965004473 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 698965004474 tRNA binding surface [nucleotide binding]; other site 698965004475 anticodon binding site; other site 698965004476 DivIVA domain; Region: DivI1A_domain; TIGR03544 698965004477 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698965004478 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 698965004479 YGGT family; Region: YGGT; cl00508 698965004480 Protein of unknown function (DUF552); Region: DUF552; cl00775 698965004481 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 698965004482 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 698965004483 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 698965004484 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 698965004485 nucleotide binding site [chemical binding]; other site 698965004486 SulA interaction site; other site 698965004487 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 698965004488 Cell division protein FtsQ; Region: FtsQ; pfam03799 698965004489 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 698965004490 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698965004491 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698965004492 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698965004493 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 698965004494 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 698965004495 active site 698965004496 homodimer interface [polypeptide binding]; other site 698965004497 cell division protein FtsW; Region: ftsW; TIGR02614 698965004498 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 698965004499 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698965004500 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698965004501 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 698965004502 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 698965004503 Mg++ binding site [ion binding]; other site 698965004504 putative catalytic motif [active] 698965004505 putative substrate binding site [chemical binding]; other site 698965004506 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 698965004507 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698965004508 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698965004509 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698965004510 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 698965004511 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698965004512 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698965004513 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698965004514 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698965004515 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698965004516 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698965004517 MraW methylase family; Region: Methyltransf_5; cl17771 698965004518 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 698965004519 cell division protein MraZ; Reviewed; Region: PRK00326 698965004520 MraZ protein; Region: MraZ; pfam02381 698965004521 MraZ protein; Region: MraZ; pfam02381 698965004522 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 698965004523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698965004524 Coenzyme A binding pocket [chemical binding]; other site 698965004525 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 698965004526 FAD binding site [chemical binding]; other site 698965004527 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698965004528 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698965004529 substrate binding pocket [chemical binding]; other site 698965004530 chain length determination region; other site 698965004531 substrate-Mg2+ binding site; other site 698965004532 catalytic residues [active] 698965004533 aspartate-rich region 1; other site 698965004534 active site lid residues [active] 698965004535 aspartate-rich region 2; other site 698965004536 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698965004537 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698965004538 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698965004539 active site 698965004540 ATP binding site [chemical binding]; other site 698965004541 substrate binding site [chemical binding]; other site 698965004542 activation loop (A-loop); other site 698965004543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698965004544 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698965004545 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698965004546 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698965004547 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698965004548 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 698965004549 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698965004550 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698965004551 putative acyl-acceptor binding pocket; other site 698965004552 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698965004553 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698965004554 nucleotide binding site [chemical binding]; other site 698965004555 Tesmin/TSO1-like CXC domain; Region: CXC; pfam03638 698965004556 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698965004557 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698965004558 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698965004559 NlpC/P60 family; Region: NLPC_P60; pfam00877 698965004560 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698965004561 NlpC/P60 family; Region: NLPC_P60; pfam00877 698965004562 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 698965004563 heme bH binding site [chemical binding]; other site 698965004564 intrachain domain interface; other site 698965004565 heme bL binding site [chemical binding]; other site 698965004566 interchain domain interface [polypeptide binding]; other site 698965004567 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 698965004568 Qo binding site; other site 698965004569 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 698965004570 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698965004571 iron-sulfur cluster [ion binding]; other site 698965004572 [2Fe-2S] cluster binding site [ion binding]; other site 698965004573 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698965004574 Cytochrome c; Region: Cytochrom_C; pfam00034 698965004575 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698965004576 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 698965004577 Subunit I/III interface [polypeptide binding]; other site 698965004578 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 698965004579 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 698965004580 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 698965004581 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 698965004582 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 698965004583 active site 698965004584 dimer interface [polypeptide binding]; other site 698965004585 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 698965004586 Ligand Binding Site [chemical binding]; other site 698965004587 Molecular Tunnel; other site 698965004588 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 698965004589 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 698965004590 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 698965004591 homotrimer interface [polypeptide binding]; other site 698965004592 Walker A motif; other site 698965004593 GTP binding site [chemical binding]; other site 698965004594 Walker B motif; other site 698965004595 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 698965004596 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 698965004597 putative dimer interface [polypeptide binding]; other site 698965004598 active site pocket [active] 698965004599 putative cataytic base [active] 698965004600 cobalamin synthase; Reviewed; Region: cobS; PRK00235 698965004601 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 698965004602 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 698965004603 homodimer interface [polypeptide binding]; other site 698965004604 substrate-cofactor binding pocket; other site 698965004605 catalytic residue [active] 698965004606 multifunctional aminopeptidase A; Provisional; Region: PRK00913 698965004607 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 698965004608 interface (dimer of trimers) [polypeptide binding]; other site 698965004609 Substrate-binding/catalytic site; other site 698965004610 Zn-binding sites [ion binding]; other site 698965004611 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 698965004612 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698965004613 E3 interaction surface; other site 698965004614 lipoyl attachment site [posttranslational modification]; other site 698965004615 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698965004616 E3 interaction surface; other site 698965004617 lipoyl attachment site [posttranslational modification]; other site 698965004618 e3 binding domain; Region: E3_binding; pfam02817 698965004619 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698965004620 lipoate-protein ligase B; Provisional; Region: PRK14345 698965004621 lipoyl synthase; Provisional; Region: PRK05481 698965004622 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698965004623 FeS/SAM binding site; other site 698965004624 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 698965004625 RDD family; Region: RDD; pfam06271 698965004626 glutamine synthetase, type I; Region: GlnA; TIGR00653 698965004627 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698965004628 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698965004629 Predicted peptidase [General function prediction only]; Region: COG4099 698965004630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 698965004631 Predicted permease [General function prediction only]; Region: COG2056 698965004632 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 698965004633 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698965004634 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698965004635 DNA-binding site [nucleotide binding]; DNA binding site 698965004636 FCD domain; Region: FCD; pfam07729 698965004637 potential frameshift: common BLAST hit: gi|38234236|ref|NP_940003.1| MFS family transporter 698965004638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965004639 putative substrate translocation pore; other site 698965004640 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 698965004641 nudix motif; other site 698965004642 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 698965004643 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 698965004644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698965004645 catalytic residue [active] 698965004646 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 698965004647 active site 698965004648 catalytic site [active] 698965004649 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 698965004650 heme binding pocket [chemical binding]; other site 698965004651 heme ligand [chemical binding]; other site 698965004652 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 698965004653 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698965004654 metal binding triad; other site 698965004655 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698965004656 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698965004657 metal binding triad; other site 698965004658 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698965004659 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 698965004660 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698965004661 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698965004662 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 698965004663 putative active site; other site 698965004664 putative metal binding residues [ion binding]; other site 698965004665 signature motif; other site 698965004666 putative triphosphate binding site [ion binding]; other site 698965004667 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 698965004668 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 698965004669 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698965004670 RNB domain; Region: RNB; pfam00773 698965004671 Predicted membrane protein [General function prediction only]; Region: COG4194 698965004672 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 698965004673 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 698965004674 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 698965004675 RNA/DNA hybrid binding site [nucleotide binding]; other site 698965004676 active site 698965004677 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698965004678 catalytic core [active] 698965004679 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 698965004680 Putative zinc ribbon domain; Region: DUF164; pfam02591 698965004681 Uncharacterized conserved protein [Function unknown]; Region: COG0327 698965004682 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698965004683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 698965004684 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698965004685 hypothetical protein; Provisional; Region: PRK07908 698965004686 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698965004687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698965004688 homodimer interface [polypeptide binding]; other site 698965004689 catalytic residue [active] 698965004690 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 698965004691 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698965004692 motif II; other site 698965004693 Low molecular weight phosphatase family; Region: LMWPc; cd00115 698965004694 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 698965004695 active site 698965004696 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 698965004697 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 698965004698 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 698965004699 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 698965004700 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 698965004701 dimer interface [polypeptide binding]; other site 698965004702 TPP-binding site [chemical binding]; other site 698965004703 Electron transfer DM13; Region: DM13; pfam10517 698965004704 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698965004705 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698965004706 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698965004707 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 698965004708 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698965004709 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698965004710 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698965004711 active site 698965004712 motif I; other site 698965004713 motif II; other site 698965004714 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698965004715 motif II; other site 698965004716 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698965004717 Beta-lactamase; Region: Beta-lactamase; pfam00144 698965004718 Predicted membrane protein [Function unknown]; Region: COG2860 698965004719 UPF0126 domain; Region: UPF0126; pfam03458 698965004720 UPF0126 domain; Region: UPF0126; pfam03458 698965004721 DNA primase; Validated; Region: dnaG; PRK05667 698965004722 CHC2 zinc finger; Region: zf-CHC2; pfam01807 698965004723 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 698965004724 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 698965004725 active site 698965004726 metal binding site [ion binding]; metal-binding site 698965004727 interdomain interaction site; other site 698965004728 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 698965004729 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 698965004730 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 698965004731 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 698965004732 glutaminase active site [active] 698965004733 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698965004734 dimer interface [polypeptide binding]; other site 698965004735 active site 698965004736 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 698965004737 dimer interface [polypeptide binding]; other site 698965004738 active site 698965004739 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 698965004740 active site 698965004741 barstar interaction site; other site 698965004742 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 698965004743 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698965004744 Zn2+ binding site [ion binding]; other site 698965004745 Mg2+ binding site [ion binding]; other site 698965004746 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 698965004747 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698965004748 putative active site [active] 698965004749 Repair protein; Region: Repair_PSII; pfam04536 698965004750 glycyl-tRNA synthetase; Provisional; Region: PRK04173 698965004751 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698965004752 motif 1; other site 698965004753 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 698965004754 active site 698965004755 motif 2; other site 698965004756 motif 3; other site 698965004757 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 698965004758 anticodon binding site; other site 698965004759 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698965004760 dimerization interface [polypeptide binding]; other site 698965004761 putative DNA binding site [nucleotide binding]; other site 698965004762 putative Zn2+ binding site [ion binding]; other site 698965004763 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698965004764 metal binding site 2 [ion binding]; metal-binding site 698965004765 putative DNA binding helix; other site 698965004766 metal binding site 1 [ion binding]; metal-binding site 698965004767 dimer interface [polypeptide binding]; other site 698965004768 structural Zn2+ binding site [ion binding]; other site 698965004769 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 698965004770 diiron binding motif [ion binding]; other site 698965004771 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 698965004772 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698965004773 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 698965004774 catalytic residue [active] 698965004775 putative FPP diphosphate binding site; other site 698965004776 putative FPP binding hydrophobic cleft; other site 698965004777 dimer interface [polypeptide binding]; other site 698965004778 putative IPP diphosphate binding site; other site 698965004779 Recombination protein O N terminal; Region: RecO_N; pfam11967 698965004780 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 698965004781 Recombination protein O C terminal; Region: RecO_C; pfam02565 698965004782 GTPase Era; Reviewed; Region: era; PRK00089 698965004783 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 698965004784 G1 box; other site 698965004785 GTP/Mg2+ binding site [chemical binding]; other site 698965004786 Switch I region; other site 698965004787 G2 box; other site 698965004788 Switch II region; other site 698965004789 G3 box; other site 698965004790 G4 box; other site 698965004791 G5 box; other site 698965004792 KH domain; Region: KH_2; pfam07650 698965004793 pyridoxamine kinase; Validated; Region: PRK05756 698965004794 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 698965004795 dimer interface [polypeptide binding]; other site 698965004796 pyridoxal binding site [chemical binding]; other site 698965004797 ATP binding site [chemical binding]; other site 698965004798 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698965004799 Domain of unknown function DUF21; Region: DUF21; pfam01595 698965004800 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698965004801 Transporter associated domain; Region: CorC_HlyC; smart01091 698965004802 metal-binding heat shock protein; Provisional; Region: PRK00016 698965004803 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 698965004804 PhoH-like protein; Region: PhoH; pfam02562 698965004805 RNA methyltransferase, RsmE family; Region: TIGR00046 698965004806 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 698965004807 chaperone protein DnaJ; Provisional; Region: PRK14278 698965004808 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698965004809 HSP70 interaction site [polypeptide binding]; other site 698965004810 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698965004811 Zn binding sites [ion binding]; other site 698965004812 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698965004813 dimer interface [polypeptide binding]; other site 698965004814 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 698965004815 coproporphyrinogen III oxidase; Validated; Region: PRK05628 698965004816 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698965004817 FeS/SAM binding site; other site 698965004818 HemN C-terminal domain; Region: HemN_C; pfam06969 698965004819 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 698965004820 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 698965004821 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 698965004822 active site 698965004823 Zn binding site [ion binding]; other site 698965004824 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698965004825 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698965004826 substrate binding pocket [chemical binding]; other site 698965004827 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 698965004828 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 698965004829 active site 698965004830 metal binding site [ion binding]; metal-binding site 698965004831 nudix motif; other site 698965004832 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698965004833 active site 698965004834 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698965004835 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698965004836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965004837 Walker A/P-loop; other site 698965004838 ATP binding site [chemical binding]; other site 698965004839 Q-loop/lid; other site 698965004840 ABC transporter signature motif; other site 698965004841 Walker B; other site 698965004842 D-loop; other site 698965004843 H-loop/switch region; other site 698965004844 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 698965004845 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698965004846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698965004847 homodimer interface [polypeptide binding]; other site 698965004848 catalytic residue [active] 698965004849 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 698965004850 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698965004851 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 698965004852 BCCT family transporter; Region: BCCT; pfam02028 698965004853 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698965004854 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 698965004855 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698965004856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698965004857 dimer interface [polypeptide binding]; other site 698965004858 conserved gate region; other site 698965004859 putative PBP binding loops; other site 698965004860 ABC-ATPase subunit interface; other site 698965004861 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698965004862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698965004863 dimer interface [polypeptide binding]; other site 698965004864 conserved gate region; other site 698965004865 putative PBP binding loops; other site 698965004866 ABC-ATPase subunit interface; other site 698965004867 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698965004868 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698965004869 Walker A/P-loop; other site 698965004870 ATP binding site [chemical binding]; other site 698965004871 Q-loop/lid; other site 698965004872 ABC transporter signature motif; other site 698965004873 Walker B; other site 698965004874 D-loop; other site 698965004875 H-loop/switch region; other site 698965004876 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698965004877 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698965004878 Walker A/P-loop; other site 698965004879 ATP binding site [chemical binding]; other site 698965004880 Q-loop/lid; other site 698965004881 ABC transporter signature motif; other site 698965004882 Walker B; other site 698965004883 D-loop; other site 698965004884 H-loop/switch region; other site 698965004885 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698965004886 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 698965004887 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 698965004888 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698965004889 catalytic residue [active] 698965004890 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698965004891 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698965004892 nucleotide binding site [chemical binding]; other site 698965004893 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 698965004894 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698965004895 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698965004896 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 698965004897 active site residue [active] 698965004898 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 698965004899 putative homodimer interface [polypeptide binding]; other site 698965004900 putative homotetramer interface [polypeptide binding]; other site 698965004901 putative allosteric switch controlling residues; other site 698965004902 putative metal binding site [ion binding]; other site 698965004903 putative homodimer-homodimer interface [polypeptide binding]; other site 698965004904 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 698965004905 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698965004906 TrkA-N domain; Region: TrkA_N; pfam02254 698965004907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965004908 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 698965004909 active site 698965004910 tetramer interface [polypeptide binding]; other site 698965004911 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698965004912 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 698965004913 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698965004914 Mrr N-terminal domain; Region: Mrr_N; pfam14338 698965004915 Restriction endonuclease; Region: Mrr_cat; pfam04471 698965004916 Abi-like protein; Region: Abi_2; pfam07751 698965004917 AAA ATPase domain; Region: AAA_16; pfam13191 698965004918 GTP-binding protein LepA; Provisional; Region: PRK05433 698965004919 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 698965004920 G1 box; other site 698965004921 putative GEF interaction site [polypeptide binding]; other site 698965004922 GTP/Mg2+ binding site [chemical binding]; other site 698965004923 Switch I region; other site 698965004924 G2 box; other site 698965004925 G3 box; other site 698965004926 Switch II region; other site 698965004927 G4 box; other site 698965004928 G5 box; other site 698965004929 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 698965004930 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 698965004931 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 698965004932 PemK-like protein; Region: PemK; pfam02452 698965004933 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 698965004934 DNA polymerase III, delta subunit; Region: holA; TIGR01128 698965004935 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 698965004936 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 698965004937 Competence protein; Region: Competence; pfam03772 698965004938 comEA protein; Region: comE; TIGR01259 698965004939 Helix-hairpin-helix motif; Region: HHH; pfam00633 698965004940 helix-hairpin-helix signature motif; other site 698965004941 EDD domain protein, DegV family; Region: DegV; TIGR00762 698965004942 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 698965004943 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698965004944 catalytic core [active] 698965004945 Oligomerisation domain; Region: Oligomerisation; cl00519 698965004946 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 698965004947 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 698965004948 active site 698965004949 (T/H)XGH motif; other site 698965004950 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 698965004951 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 698965004952 putative catalytic cysteine [active] 698965004953 gamma-glutamyl kinase; Provisional; Region: PRK05429 698965004954 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 698965004955 nucleotide binding site [chemical binding]; other site 698965004956 homotetrameric interface [polypeptide binding]; other site 698965004957 putative phosphate binding site [ion binding]; other site 698965004958 putative allosteric binding site; other site 698965004959 PUA domain; Region: PUA; pfam01472 698965004960 GTPase CgtA; Reviewed; Region: obgE; PRK12296 698965004961 GTP1/OBG; Region: GTP1_OBG; pfam01018 698965004962 Obg GTPase; Region: Obg; cd01898 698965004963 G1 box; other site 698965004964 GTP/Mg2+ binding site [chemical binding]; other site 698965004965 Switch I region; other site 698965004966 G2 box; other site 698965004967 G3 box; other site 698965004968 Switch II region; other site 698965004969 G4 box; other site 698965004970 G5 box; other site 698965004971 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 698965004972 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 698965004973 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 698965004974 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 698965004975 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698965004976 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 698965004977 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 698965004978 homodimer interface [polypeptide binding]; other site 698965004979 oligonucleotide binding site [chemical binding]; other site 698965004980 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 698965004981 active site 698965004982 multimer interface [polypeptide binding]; other site 698965004983 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 698965004984 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 698965004985 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698965004986 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 698965004987 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698965004988 active site 698965004989 HIGH motif; other site 698965004990 nucleotide binding site [chemical binding]; other site 698965004991 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698965004992 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 698965004993 active site 698965004994 KMSKS motif; other site 698965004995 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 698965004996 tRNA binding surface [nucleotide binding]; other site 698965004997 anticodon binding site; other site 698965004998 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 698965004999 malate dehydrogenase; Provisional; Region: PRK05442 698965005000 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 698965005001 NAD(P) binding site [chemical binding]; other site 698965005002 dimer interface [polypeptide binding]; other site 698965005003 malate binding site [chemical binding]; other site 698965005004 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698965005005 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698965005006 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 698965005007 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 698965005008 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 698965005009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698965005010 Walker A motif; other site 698965005011 ATP binding site [chemical binding]; other site 698965005012 Walker B motif; other site 698965005013 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 698965005014 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698965005015 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698965005016 glutamine binding [chemical binding]; other site 698965005017 catalytic triad [active] 698965005018 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 698965005019 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698965005020 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 698965005021 substrate-cofactor binding pocket; other site 698965005022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698965005023 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 698965005024 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698965005025 oligomer interface [polypeptide binding]; other site 698965005026 active site residues [active] 698965005027 Clp protease; Region: CLP_protease; pfam00574 698965005028 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698965005029 oligomer interface [polypeptide binding]; other site 698965005030 active site residues [active] 698965005031 trigger factor; Provisional; Region: tig; PRK01490 698965005032 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698965005033 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 698965005034 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 698965005035 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698965005036 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698965005037 catalytic residues [active] 698965005038 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 698965005039 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 698965005040 Zn binding site [ion binding]; other site 698965005041 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698965005042 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698965005043 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 698965005044 apolar tunnel; other site 698965005045 heme binding site [chemical binding]; other site 698965005046 dimerization interface [polypeptide binding]; other site 698965005047 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698965005048 active site 698965005049 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 698965005050 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965005051 Walker A/P-loop; other site 698965005052 ATP binding site [chemical binding]; other site 698965005053 Q-loop/lid; other site 698965005054 ABC transporter signature motif; other site 698965005055 Walker B; other site 698965005056 D-loop; other site 698965005057 H-loop/switch region; other site 698965005058 ABC transporter; Region: ABC_tran_2; pfam12848 698965005059 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698965005060 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698965005061 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698965005062 dimer interface [polypeptide binding]; other site 698965005063 ssDNA binding site [nucleotide binding]; other site 698965005064 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698965005065 Copper resistance protein D; Region: CopD; pfam05425 698965005066 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 698965005067 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 698965005068 Carbon starvation protein CstA; Region: CstA; pfam02554 698965005069 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 698965005070 Protein of unknown function (DUF466); Region: DUF466; pfam04328 698965005071 Homeodomain-like domain; Region: HTH_23; cl17451 698965005072 Helix-turn-helix domain; Region: HTH_28; pfam13518 698965005073 putative transposase OrfB; Reviewed; Region: PHA02517 698965005074 HTH-like domain; Region: HTH_21; pfam13276 698965005075 Integrase core domain; Region: rve; pfam00665 698965005076 Integrase core domain; Region: rve_2; pfam13333 698965005077 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698965005078 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 698965005079 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 698965005080 NADP binding site [chemical binding]; other site 698965005081 dimer interface [polypeptide binding]; other site 698965005082 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698965005083 classical (c) SDRs; Region: SDR_c; cd05233 698965005084 NAD(P) binding site [chemical binding]; other site 698965005085 active site 698965005086 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 698965005087 catalytic site [active] 698965005088 putative active site [active] 698965005089 putative substrate binding site [chemical binding]; other site 698965005090 dimer interface [polypeptide binding]; other site 698965005091 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698965005092 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698965005093 inhibitor site; inhibition site 698965005094 active site 698965005095 dimer interface [polypeptide binding]; other site 698965005096 catalytic residue [active] 698965005097 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 698965005098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698965005099 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 698965005100 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698965005101 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 698965005102 conserved cis-peptide bond; other site 698965005103 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 698965005104 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 698965005105 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698965005106 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 698965005107 catalytic triad [active] 698965005108 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698965005109 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698965005110 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 698965005111 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698965005112 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 698965005113 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698965005114 phosphate binding site [ion binding]; other site 698965005115 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 698965005116 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 698965005117 active site 2 [active] 698965005118 active site 1 [active] 698965005119 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 698965005120 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698965005121 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 698965005122 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 698965005123 putative NAD(P) binding site [chemical binding]; other site 698965005124 active site 698965005125 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 698965005126 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 698965005127 active site 698965005128 Glucitol operon activator protein (GutM); Region: GutM; cl01890 698965005129 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 698965005130 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 698965005131 active site 698965005132 dimerization interface [polypeptide binding]; other site 698965005133 ribonuclease PH; Reviewed; Region: rph; PRK00173 698965005134 Ribonuclease PH; Region: RNase_PH_bact; cd11362 698965005135 hexamer interface [polypeptide binding]; other site 698965005136 active site 698965005137 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 698965005138 glutamate racemase; Provisional; Region: PRK00865 698965005139 Rhomboid family; Region: Rhomboid; cl11446 698965005140 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 698965005141 putative active site pocket [active] 698965005142 cleavage site 698965005143 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 698965005144 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 698965005145 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 698965005146 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 698965005147 active site 698965005148 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 698965005149 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698965005150 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698965005151 putative Mg++ binding site [ion binding]; other site 698965005152 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 698965005153 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698965005154 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698965005155 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 698965005156 dimer interface [polypeptide binding]; other site 698965005157 putative active site [active] 698965005158 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 698965005159 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 698965005160 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 698965005161 phosphoserine phosphatase SerB; Region: serB; TIGR00338 698965005162 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698965005163 motif II; other site 698965005164 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 698965005165 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 698965005166 D-pathway; other site 698965005167 Putative ubiquinol binding site [chemical binding]; other site 698965005168 Low-spin heme (heme b) binding site [chemical binding]; other site 698965005169 Putative water exit pathway; other site 698965005170 Binuclear center (heme o3/CuB) [ion binding]; other site 698965005171 K-pathway; other site 698965005172 Putative proton exit pathway; other site 698965005173 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698965005174 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698965005175 dimer interface [polypeptide binding]; other site 698965005176 putative radical transfer pathway; other site 698965005177 diiron center [ion binding]; other site 698965005178 tyrosyl radical; other site 698965005179 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 698965005180 Ferritin-like domain; Region: Ferritin; pfam00210 698965005181 ferroxidase diiron center [ion binding]; other site 698965005182 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 698965005183 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 698965005184 Class I ribonucleotide reductase; Region: RNR_I; cd01679 698965005185 active site 698965005186 dimer interface [polypeptide binding]; other site 698965005187 catalytic residues [active] 698965005188 effector binding site; other site 698965005189 R2 peptide binding site; other site 698965005190 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698965005191 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698965005192 catalytic residues [active] 698965005193 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 698965005194 active site lid residues [active] 698965005195 substrate binding pocket [chemical binding]; other site 698965005196 catalytic residues [active] 698965005197 substrate-Mg2+ binding site; other site 698965005198 aspartate-rich region 1; other site 698965005199 aspartate-rich region 2; other site 698965005200 phytoene desaturase; Region: crtI_fam; TIGR02734 698965005201 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698965005202 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 698965005203 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 698965005204 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 698965005205 homodimer interface [polypeptide binding]; other site 698965005206 NAD binding pocket [chemical binding]; other site 698965005207 ATP binding pocket [chemical binding]; other site 698965005208 Mg binding site [ion binding]; other site 698965005209 active-site loop [active] 698965005210 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 698965005211 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 698965005212 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 698965005213 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 698965005214 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 698965005215 Predicted transcriptional regulator [Transcription]; Region: COG2345 698965005216 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 698965005217 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698965005218 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 698965005219 catalytic residues [active] 698965005220 Methylamine utilisation protein MauE; Region: MauE; pfam07291 698965005221 phosphoglucomutase; Validated; Region: PRK07564 698965005222 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 698965005223 active site 698965005224 substrate binding site [chemical binding]; other site 698965005225 metal binding site [ion binding]; metal-binding site 698965005226 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134 698965005227 CrcB-like protein; Region: CRCB; pfam02537 698965005228 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698965005229 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698965005230 FtsX-like permease family; Region: FtsX; pfam02687 698965005231 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698965005232 FtsX-like permease family; Region: FtsX; pfam02687 698965005233 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698965005234 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698965005235 Walker A/P-loop; other site 698965005236 ATP binding site [chemical binding]; other site 698965005237 Q-loop/lid; other site 698965005238 ABC transporter signature motif; other site 698965005239 Walker B; other site 698965005240 D-loop; other site 698965005241 H-loop/switch region; other site 698965005242 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698965005243 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698965005244 hinge; other site 698965005245 active site 698965005246 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 698965005247 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 698965005248 GAF domain; Region: GAF_2; pfam13185 698965005249 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698965005250 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698965005251 DNA binding residues [nucleotide binding] 698965005252 dimerization interface [polypeptide binding]; other site 698965005253 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698965005254 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698965005255 dimer interface [polypeptide binding]; other site 698965005256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698965005257 catalytic residue [active] 698965005258 serine O-acetyltransferase; Region: cysE; TIGR01172 698965005259 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 698965005260 trimer interface [polypeptide binding]; other site 698965005261 active site 698965005262 substrate binding site [chemical binding]; other site 698965005263 CoA binding site [chemical binding]; other site 698965005264 Predicted acetyltransferase [General function prediction only]; Region: COG2388 698965005265 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 698965005266 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 698965005267 putative active site [active] 698965005268 metal binding site [ion binding]; metal-binding site 698965005269 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 698965005270 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698965005271 Walker A/P-loop; other site 698965005272 ATP binding site [chemical binding]; other site 698965005273 Q-loop/lid; other site 698965005274 ABC transporter signature motif; other site 698965005275 Walker B; other site 698965005276 D-loop; other site 698965005277 H-loop/switch region; other site 698965005278 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 698965005279 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698965005280 intersubunit interface [polypeptide binding]; other site 698965005281 ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism]; Region: FepD; COG0609 698965005282 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698965005283 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698965005284 ABC-ATPase subunit interface; other site 698965005285 dimer interface [polypeptide binding]; other site 698965005286 putative PBP binding regions; other site 698965005287 potential frameshift: common BLAST hit: gi|172041139|ref|YP_001800853.1| transposase for insertion sequence 698965005288 Integrase core domain; Region: rve_3; cl15866 698965005289 HTH-like domain; Region: HTH_21; pfam13276 698965005290 Integrase core domain; Region: rve; pfam00665 698965005291 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 698965005292 Cadmium resistance transporter; Region: Cad; pfam03596 698965005293 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698965005294 dimerization interface [polypeptide binding]; other site 698965005295 putative DNA binding site [nucleotide binding]; other site 698965005296 putative Zn2+ binding site [ion binding]; other site 698965005297 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 698965005298 SdpI/YhfL protein family; Region: SdpI; pfam13630 698965005299 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 698965005300 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 698965005301 TrwC relaxase; Region: TrwC; pfam08751 698965005302 Transposase; Region: HTH_Tnp_1; cl17663 698965005303 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698965005304 HTH-like domain; Region: HTH_21; pfam13276 698965005305 Integrase core domain; Region: rve; pfam00665 698965005306 Integrase core domain; Region: rve_3; cl15866 698965005307 potential frameshift: common BLAST hit: gi|38233952|ref|NP_939719.1| transposase 698965005308 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698965005309 HTH-like domain; Region: HTH_21; pfam13276 698965005310 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 698965005311 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 698965005312 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698965005313 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698965005314 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 698965005315 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965005316 Walker A/P-loop; other site 698965005317 ATP binding site [chemical binding]; other site 698965005318 Q-loop/lid; other site 698965005319 ABC transporter signature motif; other site 698965005320 Walker B; other site 698965005321 D-loop; other site 698965005322 H-loop/switch region; other site 698965005323 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 698965005324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965005325 Walker A/P-loop; other site 698965005326 ATP binding site [chemical binding]; other site 698965005327 Q-loop/lid; other site 698965005328 ABC transporter signature motif; other site 698965005329 Walker B; other site 698965005330 D-loop; other site 698965005331 H-loop/switch region; other site 698965005332 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 698965005333 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 698965005334 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 698965005335 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 698965005336 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 698965005337 FMN binding site [chemical binding]; other site 698965005338 active site 698965005339 catalytic residues [active] 698965005340 substrate binding site [chemical binding]; other site 698965005341 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 698965005342 PhoU domain; Region: PhoU; pfam01895 698965005343 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 698965005344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698965005345 Coenzyme A binding pocket [chemical binding]; other site 698965005346 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698965005347 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698965005348 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 698965005349 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 698965005350 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 698965005351 heme-binding site [chemical binding]; other site 698965005352 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 698965005353 substrate binding site [chemical binding]; other site 698965005354 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 698965005355 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 698965005356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698965005357 catalytic residue [active] 698965005358 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 698965005359 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 698965005360 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698965005361 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 698965005362 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 698965005363 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 698965005364 dimerization interface [polypeptide binding]; other site 698965005365 putative ATP binding site [chemical binding]; other site 698965005366 amidophosphoribosyltransferase; Provisional; Region: PRK07847 698965005367 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 698965005368 active site 698965005369 tetramer interface [polypeptide binding]; other site 698965005370 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698965005371 active site 698965005372 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 698965005373 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 698965005374 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698965005375 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698965005376 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698965005377 dimer interface [polypeptide binding]; other site 698965005378 putative radical transfer pathway; other site 698965005379 diiron center [ion binding]; other site 698965005380 tyrosyl radical; other site 698965005381 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 698965005382 catalytic residues [active] 698965005383 dimer interface [polypeptide binding]; other site 698965005384 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 698965005385 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698965005386 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 698965005387 ATP binding site [chemical binding]; other site 698965005388 active site 698965005389 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 698965005390 substrate binding site [chemical binding]; other site 698965005391 adenylosuccinate lyase; Region: purB; TIGR00928 698965005392 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 698965005393 tetramer interface [polypeptide binding]; other site 698965005394 aspartate aminotransferase; Provisional; Region: PRK05764 698965005395 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698965005396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698965005397 homodimer interface [polypeptide binding]; other site 698965005398 catalytic residue [active] 698965005399 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 698965005400 TrkA-N domain; Region: TrkA_N; pfam02254 698965005401 TrkA-C domain; Region: TrkA_C; pfam02080 698965005402 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 698965005403 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 698965005404 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 698965005405 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 698965005406 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 698965005407 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 698965005408 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 698965005409 nucleotide binding site/active site [active] 698965005410 HIT family signature motif; other site 698965005411 catalytic residue [active] 698965005412 PGAP1-like protein; Region: PGAP1; pfam07819 698965005413 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698965005414 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698965005415 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698965005416 dimerization interface [polypeptide binding]; other site 698965005417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698965005418 dimer interface [polypeptide binding]; other site 698965005419 phosphorylation site [posttranslational modification] 698965005420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698965005421 ATP binding site [chemical binding]; other site 698965005422 Mg2+ binding site [ion binding]; other site 698965005423 G-X-G motif; other site 698965005424 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698965005425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698965005426 active site 698965005427 phosphorylation site [posttranslational modification] 698965005428 intermolecular recognition site; other site 698965005429 dimerization interface [polypeptide binding]; other site 698965005430 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698965005431 DNA binding site [nucleotide binding] 698965005432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965005433 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698965005434 putative substrate translocation pore; other site 698965005435 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698965005436 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698965005437 xanthine permease; Region: pbuX; TIGR03173 698965005438 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 698965005439 pyruvate dehydrogenase; Provisional; Region: PRK06546 698965005440 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 698965005441 PYR/PP interface [polypeptide binding]; other site 698965005442 dimer interface [polypeptide binding]; other site 698965005443 tetramer interface [polypeptide binding]; other site 698965005444 TPP binding site [chemical binding]; other site 698965005445 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698965005446 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 698965005447 TPP-binding site [chemical binding]; other site 698965005448 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698965005449 Uncharacterized conserved protein [Function unknown]; Region: COG3610 698965005450 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698965005451 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698965005452 Uncharacterized conserved protein [Function unknown]; Region: COG3610 698965005453 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 698965005454 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 698965005455 active site 698965005456 homotetramer interface [polypeptide binding]; other site 698965005457 META domain; Region: META; cl01245 698965005458 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 698965005459 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 698965005460 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698965005461 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698965005462 DNA binding site [nucleotide binding] 698965005463 domain linker motif; other site 698965005464 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 698965005465 putative dimerization interface [polypeptide binding]; other site 698965005466 putative ligand binding site [chemical binding]; other site 698965005467 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698965005468 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 698965005469 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698965005470 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 698965005471 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698965005472 active site 698965005473 HIGH motif; other site 698965005474 nucleotide binding site [chemical binding]; other site 698965005475 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698965005476 KMSKS motif; other site 698965005477 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698965005478 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 698965005479 homotrimer interaction site [polypeptide binding]; other site 698965005480 zinc binding site [ion binding]; other site 698965005481 CDP-binding sites; other site 698965005482 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 698965005483 substrate binding site; other site 698965005484 dimer interface; other site 698965005485 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 698965005486 DNA repair protein RadA; Provisional; Region: PRK11823 698965005487 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698965005488 Walker A motif; other site 698965005489 ATP binding site [chemical binding]; other site 698965005490 Walker B motif; other site 698965005491 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698965005492 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 698965005493 active site clefts [active] 698965005494 zinc binding site [ion binding]; other site 698965005495 dimer interface [polypeptide binding]; other site 698965005496 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698965005497 endonuclease III; Region: ENDO3c; smart00478 698965005498 minor groove reading motif; other site 698965005499 helix-hairpin-helix signature motif; other site 698965005500 substrate binding pocket [chemical binding]; other site 698965005501 active site 698965005502 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698965005503 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698965005504 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 698965005505 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 698965005506 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 698965005507 Clp amino terminal domain; Region: Clp_N; pfam02861 698965005508 Clp amino terminal domain; Region: Clp_N; pfam02861 698965005509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698965005510 Walker A motif; other site 698965005511 ATP binding site [chemical binding]; other site 698965005512 Walker B motif; other site 698965005513 arginine finger; other site 698965005514 UvrB/uvrC motif; Region: UVR; pfam02151 698965005515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698965005516 Walker A motif; other site 698965005517 ATP binding site [chemical binding]; other site 698965005518 Walker B motif; other site 698965005519 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698965005520 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 698965005521 oligomer interface [polypeptide binding]; other site 698965005522 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698965005523 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698965005524 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 698965005525 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698965005526 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698965005527 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 698965005528 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 698965005529 active site 698965005530 catalytic motif [active] 698965005531 Zn binding site [ion binding]; other site 698965005532 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 698965005533 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 698965005534 Nucleoside recognition; Region: Gate; pfam07670 698965005535 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 698965005536 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 698965005537 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698965005538 dimer interface [polypeptide binding]; other site 698965005539 putative anticodon binding site; other site 698965005540 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698965005541 motif 1; other site 698965005542 dimer interface [polypeptide binding]; other site 698965005543 active site 698965005544 motif 2; other site 698965005545 motif 3; other site 698965005546 YcaO-like family; Region: YcaO; pfam02624 698965005547 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 698965005548 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 698965005549 NADPH bind site [chemical binding]; other site 698965005550 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 698965005551 dimer interface [polypeptide binding]; other site 698965005552 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 698965005553 SpaB C-terminal domain; Region: SpaB_C; pfam14028 698965005554 YcaO-like family; Region: YcaO; pfam02624 698965005555 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 698965005556 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698965005557 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698965005558 Walker A/P-loop; other site 698965005559 ATP binding site [chemical binding]; other site 698965005560 Q-loop/lid; other site 698965005561 ABC transporter signature motif; other site 698965005562 Walker B; other site 698965005563 D-loop; other site 698965005564 H-loop/switch region; other site 698965005565 potential frameshift: common BLAST hit: gi|62389924|ref|YP_225326.1| transposase 698965005566 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698965005567 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698965005568 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698965005569 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 698965005570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 698965005571 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698965005572 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698965005573 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698965005574 active site 698965005575 KMSKS motif; other site 698965005576 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 698965005577 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 698965005578 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 698965005579 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 698965005580 catalytic center binding site [active] 698965005581 ATP binding site [chemical binding]; other site 698965005582 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 698965005583 homooctamer interface [polypeptide binding]; other site 698965005584 active site 698965005585 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698965005586 dihydropteroate synthase; Region: DHPS; TIGR01496 698965005587 substrate binding pocket [chemical binding]; other site 698965005588 dimer interface [polypeptide binding]; other site 698965005589 inhibitor binding site; inhibition site 698965005590 Protein of unknown function, DUF393; Region: DUF393; cl01136 698965005591 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 698965005592 homodecamer interface [polypeptide binding]; other site 698965005593 GTP cyclohydrolase I; Provisional; Region: PLN03044 698965005594 active site 698965005595 putative catalytic site residues [active] 698965005596 zinc binding site [ion binding]; other site 698965005597 GTP-CH-I/GFRP interaction surface; other site 698965005598 FtsH Extracellular; Region: FtsH_ext; pfam06480 698965005599 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 698965005600 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698965005601 Walker A motif; other site 698965005602 ATP binding site [chemical binding]; other site 698965005603 Walker B motif; other site 698965005604 arginine finger; other site 698965005605 Peptidase family M41; Region: Peptidase_M41; pfam01434 698965005606 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698965005607 active site 698965005608 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 698965005609 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 698965005610 Ligand Binding Site [chemical binding]; other site 698965005611 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 698965005612 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 698965005613 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 698965005614 dimer interface [polypeptide binding]; other site 698965005615 substrate binding site [chemical binding]; other site 698965005616 metal binding sites [ion binding]; metal-binding site 698965005617 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698965005618 active site residue [active] 698965005619 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698965005620 MarR family; Region: MarR_2; pfam12802 698965005621 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698965005622 active site 698965005623 CoA binding site [chemical binding]; other site 698965005624 AMP binding site [chemical binding]; other site 698965005625 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698965005626 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 698965005627 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698965005628 putative trimer interface [polypeptide binding]; other site 698965005629 putative CoA binding site [chemical binding]; other site 698965005630 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698965005631 putative trimer interface [polypeptide binding]; other site 698965005632 putative CoA binding site [chemical binding]; other site 698965005633 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698965005634 metal ion-dependent adhesion site (MIDAS); other site 698965005635 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698965005636 active site 698965005637 catalytic site [active] 698965005638 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698965005639 potential frameshift: common BLAST hit: gi|38234578|ref|NP_940345.1| membrane-anchored protein 698965005640 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698965005641 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 698965005642 active site 698965005643 catalytic triad [active] 698965005644 oxyanion hole [active] 698965005645 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698965005646 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698965005647 ring oligomerisation interface [polypeptide binding]; other site 698965005648 ATP/Mg binding site [chemical binding]; other site 698965005649 stacking interactions; other site 698965005650 hinge regions; other site 698965005651 hypothetical protein; Provisional; Region: PRK07907 698965005652 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 698965005653 active site 698965005654 metal binding site [ion binding]; metal-binding site 698965005655 dimer interface [polypeptide binding]; other site 698965005656 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698965005657 carboxylate-amine ligase; Provisional; Region: PRK13517 698965005658 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 698965005659 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698965005660 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698965005661 active site 698965005662 catalytic residues [active] 698965005663 metal binding site [ion binding]; metal-binding site 698965005664 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698965005665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698965005666 Coenzyme A binding pocket [chemical binding]; other site 698965005667 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698965005668 putative catalytic site [active] 698965005669 putative metal binding site [ion binding]; other site 698965005670 putative phosphate binding site [ion binding]; other site 698965005671 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 698965005672 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 698965005673 putative active site [active] 698965005674 catalytic site [active] 698965005675 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 698965005676 putative active site [active] 698965005677 catalytic site [active] 698965005678 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698965005679 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698965005680 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965005681 Walker A/P-loop; other site 698965005682 ATP binding site [chemical binding]; other site 698965005683 Q-loop/lid; other site 698965005684 ABC transporter signature motif; other site 698965005685 Walker B; other site 698965005686 D-loop; other site 698965005687 H-loop/switch region; other site 698965005688 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698965005689 HTH-like domain; Region: HTH_21; pfam13276 698965005690 Integrase core domain; Region: rve; pfam00665 698965005691 Integrase core domain; Region: rve_2; pfam13333 698965005692 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698965005693 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698965005694 active site 698965005695 ATP binding site [chemical binding]; other site 698965005696 substrate binding site [chemical binding]; other site 698965005697 activation loop (A-loop); other site 698965005698 propionate/acetate kinase; Provisional; Region: PRK12379 698965005699 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 698965005700 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 698965005701 ferredoxin-NADP+ reductase; Region: PLN02852 698965005702 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698965005703 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698965005704 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 698965005705 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698965005706 active site 698965005707 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698965005708 putative active site [active] 698965005709 Helix-turn-helix domain; Region: HTH_38; pfam13936 698965005710 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698965005711 Integrase core domain; Region: rve; pfam00665 698965005712 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 698965005713 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 698965005714 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 698965005715 GDP-binding site [chemical binding]; other site 698965005716 ACT binding site; other site 698965005717 IMP binding site; other site 698965005718 Predicted membrane protein [Function unknown]; Region: COG4129 698965005719 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698965005720 chromosome segregation protein; Provisional; Region: PRK03918 698965005721 Predicted membrane protein [Function unknown]; Region: COG4129 698965005722 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698965005723 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 698965005724 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698965005725 Abi-like protein; Region: Abi_2; pfam07751 698965005726 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 698965005727 YfbU domain; Region: YfbU; cl01137 698965005728 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698965005729 MULE transposase domain; Region: MULE; pfam10551 698965005730 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698965005731 Abi-like protein; Region: Abi_2; cl01988 698965005732 HTH-like domain; Region: HTH_21; pfam13276 698965005733 Integrase core domain; Region: rve; pfam00665 698965005734 Transposase; Region: HTH_Tnp_1; cl17663 698965005735 Integrase core domain; Region: rve; pfam00665 698965005736 Integrase core domain; Region: rve_3; pfam13683 698965005737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698965005738 NADH(P)-binding; Region: NAD_binding_10; pfam13460 698965005739 NAD(P) binding site [chemical binding]; other site 698965005740 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698965005741 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 698965005742 Condensation domain; Region: Condensation; pfam00668 698965005743 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698965005744 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698965005745 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 698965005746 acyl-activating enzyme (AAE) consensus motif; other site 698965005747 AMP binding site [chemical binding]; other site 698965005748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698965005749 S-adenosylmethionine binding site [chemical binding]; other site 698965005750 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698965005751 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698965005752 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 698965005753 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698965005754 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 698965005755 acyl-activating enzyme (AAE) consensus motif; other site 698965005756 AMP binding site [chemical binding]; other site 698965005757 active site 698965005758 CoA binding site [chemical binding]; other site 698965005759 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698965005760 Condensation domain; Region: Condensation; pfam00668 698965005761 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698965005762 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698965005763 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 698965005764 acyl-activating enzyme (AAE) consensus motif; other site 698965005765 AMP binding site [chemical binding]; other site 698965005766 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698965005767 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698965005768 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698965005769 Condensation domain; Region: Condensation; pfam00668 698965005770 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698965005771 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698965005772 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 698965005773 acyl-activating enzyme (AAE) consensus motif; other site 698965005774 AMP binding site [chemical binding]; other site 698965005775 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698965005776 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 698965005777 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698965005778 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698965005779 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698965005780 Walker A/P-loop; other site 698965005781 ATP binding site [chemical binding]; other site 698965005782 Q-loop/lid; other site 698965005783 ABC transporter signature motif; other site 698965005784 Walker B; other site 698965005785 D-loop; other site 698965005786 H-loop/switch region; other site 698965005787 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698965005788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965005789 Walker A/P-loop; other site 698965005790 ATP binding site [chemical binding]; other site 698965005791 Q-loop/lid; other site 698965005792 ABC transporter signature motif; other site 698965005793 Walker B; other site 698965005794 D-loop; other site 698965005795 H-loop/switch region; other site 698965005796 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698965005797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965005798 Walker A/P-loop; other site 698965005799 ATP binding site [chemical binding]; other site 698965005800 Q-loop/lid; other site 698965005801 ABC transporter signature motif; other site 698965005802 Walker B; other site 698965005803 D-loop; other site 698965005804 H-loop/switch region; other site 698965005805 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698965005806 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965005807 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698965005808 Walker A/P-loop; other site 698965005809 ATP binding site [chemical binding]; other site 698965005810 Q-loop/lid; other site 698965005811 ABC transporter signature motif; other site 698965005812 Walker B; other site 698965005813 D-loop; other site 698965005814 H-loop/switch region; other site 698965005815 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 698965005816 Anticodon binding domain of tRNAs; Region: HGTP_anticodon2; pfam12745 698965005817 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 698965005818 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 698965005819 homodimer interface [polypeptide binding]; other site 698965005820 active site 698965005821 TDP-binding site; other site 698965005822 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 698965005823 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 698965005824 active site 698965005825 substrate binding site [chemical binding]; other site 698965005826 trimer interface [polypeptide binding]; other site 698965005827 CoA binding site [chemical binding]; other site 698965005828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965005829 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 698965005830 Walker A/P-loop; other site 698965005831 ATP binding site [chemical binding]; other site 698965005832 Q-loop/lid; other site 698965005833 ABC transporter signature motif; other site 698965005834 Walker B; other site 698965005835 D-loop; other site 698965005836 H-loop/switch region; other site 698965005837 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 698965005838 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698965005839 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698965005840 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698965005841 Integrase core domain; Region: rve_3; pfam13683 698965005842 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698965005843 Integrase core domain; Region: rve; pfam00665 698965005844 putative transposase OrfB; Reviewed; Region: PHA02517 698965005845 HTH-like domain; Region: HTH_21; pfam13276 698965005846 Integrase core domain; Region: rve; pfam00665 698965005847 Integrase core domain; Region: rve_2; pfam13333 698965005848 Helix-turn-helix domain; Region: HTH_28; pfam13518 698965005849 Helix-turn-helix domain; Region: HTH_38; pfam13936 698965005850 HTH-like domain; Region: HTH_21; pfam13276 698965005851 Integrase core domain; Region: rve; pfam00665 698965005852 TQXA domain; Region: TQXA_dom; TIGR03934 698965005853 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 698965005854 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 698965005855 active site 698965005856 intersubunit interface [polypeptide binding]; other site 698965005857 zinc binding site [ion binding]; other site 698965005858 Na+ binding site [ion binding]; other site 698965005859 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 698965005860 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698965005861 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698965005862 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698965005863 active site 698965005864 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698965005865 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698965005866 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698965005867 active site residue [active] 698965005868 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698965005869 active site residue [active] 698965005870 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 698965005871 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 698965005872 Clp amino terminal domain; Region: Clp_N; pfam02861 698965005873 Clp amino terminal domain; Region: Clp_N; pfam02861 698965005874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698965005875 Walker A motif; other site 698965005876 ATP binding site [chemical binding]; other site 698965005877 Walker B motif; other site 698965005878 arginine finger; other site 698965005879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698965005880 Walker A motif; other site 698965005881 ATP binding site [chemical binding]; other site 698965005882 Walker B motif; other site 698965005883 arginine finger; other site 698965005884 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698965005885 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698965005886 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 698965005887 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698965005888 Walker A/P-loop; other site 698965005889 ATP binding site [chemical binding]; other site 698965005890 Q-loop/lid; other site 698965005891 ABC transporter signature motif; other site 698965005892 Walker B; other site 698965005893 D-loop; other site 698965005894 H-loop/switch region; other site 698965005895 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698965005896 EamA-like transporter family; Region: EamA; pfam00892 698965005897 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698965005898 EamA-like transporter family; Region: EamA; pfam00892 698965005899 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 698965005900 FAD binding pocket [chemical binding]; other site 698965005901 FAD binding motif [chemical binding]; other site 698965005902 phosphate binding motif [ion binding]; other site 698965005903 beta-alpha-beta structure motif; other site 698965005904 NAD binding pocket [chemical binding]; other site 698965005905 Predicted amidohydrolase [General function prediction only]; Region: COG0388 698965005906 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 698965005907 putative active site [active] 698965005908 catalytic triad [active] 698965005909 putative dimer interface [polypeptide binding]; other site 698965005910 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 698965005911 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 698965005912 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 698965005913 NAD binding site [chemical binding]; other site 698965005914 substrate binding site [chemical binding]; other site 698965005915 catalytic Zn binding site [ion binding]; other site 698965005916 tetramer interface [polypeptide binding]; other site 698965005917 structural Zn binding site [ion binding]; other site 698965005918 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698965005919 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698965005920 NAD(P) binding site [chemical binding]; other site 698965005921 catalytic residues [active] 698965005922 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698965005923 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698965005924 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698965005925 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 698965005926 DNA binding residues [nucleotide binding] 698965005927 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698965005928 putative dimer interface [polypeptide binding]; other site 698965005929 chaperone protein DnaJ; Provisional; Region: PRK14279 698965005930 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698965005931 HSP70 interaction site [polypeptide binding]; other site 698965005932 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698965005933 Zn binding sites [ion binding]; other site 698965005934 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698965005935 dimer interface [polypeptide binding]; other site 698965005936 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 698965005937 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 698965005938 dimer interface [polypeptide binding]; other site 698965005939 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 698965005940 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 698965005941 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 698965005942 nucleotide binding site [chemical binding]; other site 698965005943 NEF interaction site [polypeptide binding]; other site 698965005944 SBD interface [polypeptide binding]; other site 698965005945 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698965005946 PAS domain; Region: PAS_9; pfam13426 698965005947 putative active site [active] 698965005948 heme pocket [chemical binding]; other site 698965005949 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698965005950 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698965005951 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698965005952 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698965005953 Walker A/P-loop; other site 698965005954 ATP binding site [chemical binding]; other site 698965005955 Q-loop/lid; other site 698965005956 ABC transporter signature motif; other site 698965005957 Walker B; other site 698965005958 D-loop; other site 698965005959 H-loop/switch region; other site 698965005960 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698965005961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698965005962 dimer interface [polypeptide binding]; other site 698965005963 conserved gate region; other site 698965005964 putative PBP binding loops; other site 698965005965 ABC-ATPase subunit interface; other site 698965005966 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698965005967 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 698965005968 Walker A/P-loop; other site 698965005969 ATP binding site [chemical binding]; other site 698965005970 Q-loop/lid; other site 698965005971 ABC transporter signature motif; other site 698965005972 Walker B; other site 698965005973 D-loop; other site 698965005974 H-loop/switch region; other site 698965005975 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698965005976 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698965005977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698965005978 dimer interface [polypeptide binding]; other site 698965005979 conserved gate region; other site 698965005980 putative PBP binding loops; other site 698965005981 ABC-ATPase subunit interface; other site 698965005982 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698965005983 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 698965005984 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698965005985 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698965005986 aminotransferase; Validated; Region: PRK07777 698965005987 ferredoxin-NADP+ reductase; Region: PLN02852 698965005988 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 698965005989 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 698965005990 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 698965005991 dimerization interface [polypeptide binding]; other site 698965005992 ATP binding site [chemical binding]; other site 698965005993 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 698965005994 dimerization interface [polypeptide binding]; other site 698965005995 ATP binding site [chemical binding]; other site 698965005996 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 698965005997 putative active site [active] 698965005998 catalytic triad [active] 698965005999 potential frameshift: common BLAST hit: gi|68535225|ref|YP_249930.1| acetyl-CoA acetyltransferase 698965006000 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 698965006001 active site 698965006002 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698965006003 substrate binding site [chemical binding]; other site 698965006004 oxyanion hole (OAH) forming residues; other site 698965006005 trimer interface [polypeptide binding]; other site 698965006006 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 698965006007 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 698965006008 active site 698965006009 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 698965006010 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 698965006011 FAD binding pocket [chemical binding]; other site 698965006012 FAD binding motif [chemical binding]; other site 698965006013 phosphate binding motif [ion binding]; other site 698965006014 NAD binding pocket [chemical binding]; other site 698965006015 Siderophore-interacting protein; Region: SIP; pfam04954 698965006016 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698965006017 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698965006018 Walker A/P-loop; other site 698965006019 ATP binding site [chemical binding]; other site 698965006020 Q-loop/lid; other site 698965006021 ABC transporter signature motif; other site 698965006022 Walker B; other site 698965006023 D-loop; other site 698965006024 H-loop/switch region; other site 698965006025 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698965006026 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698965006027 ABC-ATPase subunit interface; other site 698965006028 dimer interface [polypeptide binding]; other site 698965006029 putative PBP binding regions; other site 698965006030 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698965006031 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698965006032 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698965006033 ABC-ATPase subunit interface; other site 698965006034 dimer interface [polypeptide binding]; other site 698965006035 putative PBP binding regions; other site 698965006036 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 698965006037 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698965006038 siderophore binding site; other site 698965006039 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 698965006040 ferredoxin-NADP+ reductase; Region: PLN02852 698965006041 Permease; Region: Permease; cl00510 698965006042 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698965006043 4Fe-4S binding domain; Region: Fer4; cl02805 698965006044 Cysteine-rich domain; Region: CCG; pfam02754 698965006045 Cysteine-rich domain; Region: CCG; pfam02754 698965006046 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 698965006047 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698965006048 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 698965006049 putative NAD(P) binding site [chemical binding]; other site 698965006050 catalytic Zn binding site [ion binding]; other site 698965006051 aminotransferase AlaT; Validated; Region: PRK09265 698965006052 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698965006053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698965006054 homodimer interface [polypeptide binding]; other site 698965006055 catalytic residue [active] 698965006056 YibE/F-like protein; Region: YibE_F; pfam07907 698965006057 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 698965006058 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 698965006059 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698965006060 dimer interface [polypeptide binding]; other site 698965006061 putative anticodon binding site; other site 698965006062 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698965006063 motif 1; other site 698965006064 dimer interface [polypeptide binding]; other site 698965006065 active site 698965006066 motif 2; other site 698965006067 motif 3; other site 698965006068 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698965006069 PGAP1-like protein; Region: PGAP1; pfam07819 698965006070 Protein of unknown function (DUF998); Region: DUF998; pfam06197 698965006071 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 698965006072 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 698965006073 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 698965006074 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698965006075 trimer interface [polypeptide binding]; other site 698965006076 active site 698965006077 Prophage antirepressor [Transcription]; Region: COG3617 698965006078 BRO family, N-terminal domain; Region: Bro-N; smart01040 698965006079 Abi-like protein; Region: Abi_2; cl01988 698965006080 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 698965006081 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698965006082 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698965006083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965006084 Walker A/P-loop; other site 698965006085 ATP binding site [chemical binding]; other site 698965006086 Q-loop/lid; other site 698965006087 ABC transporter signature motif; other site 698965006088 Walker B; other site 698965006089 D-loop; other site 698965006090 H-loop/switch region; other site 698965006091 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698965006092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965006093 Walker A/P-loop; other site 698965006094 ATP binding site [chemical binding]; other site 698965006095 Q-loop/lid; other site 698965006096 ABC transporter signature motif; other site 698965006097 Walker B; other site 698965006098 D-loop; other site 698965006099 H-loop/switch region; other site 698965006100 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 698965006101 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 698965006102 active site 698965006103 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 698965006104 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698965006105 Condensation domain; Region: Condensation; pfam00668 698965006106 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698965006107 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698965006108 Condensation domain; Region: Condensation; pfam00668 698965006109 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698965006110 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698965006111 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698965006112 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 698965006113 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698965006114 Condensation domain; Region: Condensation; pfam00668 698965006115 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698965006116 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 698965006117 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 698965006118 acyl-activating enzyme (AAE) consensus motif; other site 698965006119 AMP binding site [chemical binding]; other site 698965006120 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698965006121 Condensation domain; Region: Condensation; pfam00668 698965006122 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698965006123 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698965006124 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698965006125 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 698965006126 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698965006127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698965006128 conserved gate region; other site 698965006129 putative PBP binding loops; other site 698965006130 ABC-ATPase subunit interface; other site 698965006131 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698965006132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698965006133 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698965006134 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 698965006135 Walker A/P-loop; other site 698965006136 ATP binding site [chemical binding]; other site 698965006137 Q-loop/lid; other site 698965006138 ABC transporter signature motif; other site 698965006139 Walker B; other site 698965006140 D-loop; other site 698965006141 H-loop/switch region; other site 698965006142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965006143 Walker A/P-loop; other site 698965006144 ATP binding site [chemical binding]; other site 698965006145 Q-loop/lid; other site 698965006146 ABC transporter signature motif; other site 698965006147 Walker B; other site 698965006148 D-loop; other site 698965006149 H-loop/switch region; other site 698965006150 metabolite-proton symporter; Region: 2A0106; TIGR00883 698965006151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965006152 putative substrate translocation pore; other site 698965006153 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698965006154 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 698965006155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965006156 putative substrate translocation pore; other site 698965006157 YwiC-like protein; Region: YwiC; pfam14256 698965006158 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698965006159 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698965006160 VanW like protein; Region: VanW; pfam04294 698965006161 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 698965006162 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 698965006163 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 698965006164 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698965006165 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698965006166 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698965006167 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698965006168 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698965006169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698965006170 S-adenosylmethionine binding site [chemical binding]; other site 698965006171 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 698965006172 active site 698965006173 substrate-binding site [chemical binding]; other site 698965006174 metal-binding site [ion binding] 698965006175 GTP binding site [chemical binding]; other site 698965006176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698965006177 S-adenosylmethionine binding site [chemical binding]; other site 698965006178 LabA_like proteins; Region: LabA_like; cd06167 698965006179 putative metal binding site [ion binding]; other site 698965006180 MMPL family; Region: MMPL; pfam03176 698965006181 MMPL family; Region: MMPL; pfam03176 698965006182 Predicted integral membrane protein [Function unknown]; Region: COG0392 698965006183 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 698965006184 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 698965006185 TQXA domain; Region: TQXA_dom; TIGR03934 698965006186 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 698965006187 TQXA domain; Region: TQXA_dom; TIGR03934 698965006188 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 698965006189 active site 698965006190 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698965006191 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698965006192 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698965006193 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698965006194 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 698965006195 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 698965006196 active site 698965006197 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 698965006198 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698965006199 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 698965006200 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 698965006201 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 698965006202 acyl-activating enzyme (AAE) consensus motif; other site 698965006203 active site 698965006204 Cutinase; Region: Cutinase; pfam01083 698965006205 Putative esterase; Region: Esterase; pfam00756 698965006206 S-formylglutathione hydrolase; Region: PLN02442 698965006207 LGFP repeat; Region: LGFP; pfam08310 698965006208 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698965006209 LGFP repeat; Region: LGFP; pfam08310 698965006210 LGFP repeat; Region: LGFP; pfam08310 698965006211 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698965006212 putative transposase OrfB; Reviewed; Region: PHA02517 698965006213 HTH-like domain; Region: HTH_21; pfam13276 698965006214 Integrase core domain; Region: rve; pfam00665 698965006215 Integrase core domain; Region: rve_2; pfam13333 698965006216 Homeodomain-like domain; Region: HTH_23; cl17451 698965006217 Helix-turn-helix domain; Region: HTH_28; pfam13518 698965006218 Predicted esterase [General function prediction only]; Region: COG0627 698965006219 S-formylglutathione hydrolase; Region: PLN02442 698965006220 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 698965006221 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 698965006222 UbiA prenyltransferase family; Region: UbiA; pfam01040 698965006223 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698965006224 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698965006225 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698965006226 active site 698965006227 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698965006228 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698965006229 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698965006230 NAD(P) binding site [chemical binding]; other site 698965006231 catalytic residues [active] 698965006232 BCCT family transporter; Region: BCCT; cl00569 698965006233 choline dehydrogenase; Validated; Region: PRK02106 698965006234 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698965006235 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 698965006236 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698965006237 UDP-galactopyranose mutase; Region: GLF; pfam03275 698965006238 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 698965006239 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 698965006240 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698965006241 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965006242 ABC transporter signature motif; other site 698965006243 Walker B; other site 698965006244 D-loop; other site 698965006245 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698965006246 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698965006247 amidase catalytic site [active] 698965006248 Zn binding residues [ion binding]; other site 698965006249 substrate binding site [chemical binding]; other site 698965006250 LGFP repeat; Region: LGFP; pfam08310 698965006251 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 698965006252 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 698965006253 RloB-like protein; Region: RloB; pfam13707 698965006254 Predicted ATPases [General function prediction only]; Region: COG1106 698965006255 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965006256 Walker A/P-loop; other site 698965006257 ATP binding site [chemical binding]; other site 698965006258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965006259 Walker B; other site 698965006260 D-loop; other site 698965006261 H-loop/switch region; other site 698965006262 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698965006263 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698965006264 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698965006265 Walker A/P-loop; other site 698965006266 ATP binding site [chemical binding]; other site 698965006267 Q-loop/lid; other site 698965006268 ABC transporter signature motif; other site 698965006269 Walker B; other site 698965006270 D-loop; other site 698965006271 H-loop/switch region; other site 698965006272 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698965006273 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698965006274 siderophore binding site; other site 698965006275 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698965006276 ABC-ATPase subunit interface; other site 698965006277 dimer interface [polypeptide binding]; other site 698965006278 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698965006279 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698965006280 ABC-ATPase subunit interface; other site 698965006281 putative PBP binding regions; other site 698965006282 glycerol kinase; Provisional; Region: glpK; PRK00047 698965006283 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 698965006284 N- and C-terminal domain interface [polypeptide binding]; other site 698965006285 active site 698965006286 MgATP binding site [chemical binding]; other site 698965006287 catalytic site [active] 698965006288 metal binding site [ion binding]; metal-binding site 698965006289 putative homotetramer interface [polypeptide binding]; other site 698965006290 glycerol binding site [chemical binding]; other site 698965006291 homodimer interface [polypeptide binding]; other site 698965006292 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 698965006293 amphipathic channel; other site 698965006294 Asn-Pro-Ala signature motifs; other site 698965006295 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 698965006296 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698965006297 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698965006298 putative acyl-acceptor binding pocket; other site 698965006299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698965006300 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698965006301 active site 698965006302 motif I; other site 698965006303 motif II; other site 698965006304 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698965006305 seryl-tRNA synthetase; Provisional; Region: PRK05431 698965006306 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 698965006307 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 698965006308 dimer interface [polypeptide binding]; other site 698965006309 active site 698965006310 motif 1; other site 698965006311 motif 2; other site 698965006312 motif 3; other site 698965006313 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698965006314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698965006315 DNA-binding site [nucleotide binding]; DNA binding site 698965006316 UTRA domain; Region: UTRA; pfam07702 698965006317 Septum formation; Region: Septum_form; pfam13845 698965006318 Septum formation; Region: Septum_form; pfam13845 698965006319 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 698965006320 AAA domain; Region: AAA_14; pfam13173 698965006321 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 698965006322 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698965006323 catalytic core [active] 698965006324 prephenate dehydratase; Provisional; Region: PRK11898 698965006325 Prephenate dehydratase; Region: PDT; pfam00800 698965006326 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 698965006327 putative L-Phe binding site [chemical binding]; other site 698965006328 Amidase; Region: Amidase; cl11426 698965006329 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698965006330 CAAX protease self-immunity; Region: Abi; pfam02517 698965006331 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 698965006332 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698965006333 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698965006334 amino acid carrier protein; Region: agcS; TIGR00835 698965006335 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698965006336 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 698965006337 catalytic triad [active] 698965006338 catalytic triad [active] 698965006339 oxyanion hole [active] 698965006340 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698965006341 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 698965006342 putative active site [active] 698965006343 catalytic site [active] 698965006344 putative metal binding site [ion binding]; other site 698965006345 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 698965006346 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 698965006347 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698965006348 NAD binding site [chemical binding]; other site 698965006349 dimer interface [polypeptide binding]; other site 698965006350 substrate binding site [chemical binding]; other site 698965006351 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 698965006352 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 698965006353 motif I; other site 698965006354 active site 698965006355 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698965006356 motif II; other site 698965006357 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698965006358 methionine sulfoxide reductase A; Provisional; Region: PRK00058 698965006359 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 698965006360 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 698965006361 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 698965006362 Predicted flavoprotein [General function prediction only]; Region: COG0431 698965006363 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698965006364 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 698965006365 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 698965006366 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698965006367 Lsr2; Region: Lsr2; pfam11774 698965006368 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698965006369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698965006370 active site 698965006371 phosphorylation site [posttranslational modification] 698965006372 intermolecular recognition site; other site 698965006373 dimerization interface [polypeptide binding]; other site 698965006374 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698965006375 DNA binding residues [nucleotide binding] 698965006376 dimerization interface [polypeptide binding]; other site 698965006377 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698965006378 Histidine kinase; Region: HisKA_3; pfam07730 698965006379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698965006380 ATP binding site [chemical binding]; other site 698965006381 Mg2+ binding site [ion binding]; other site 698965006382 G-X-G motif; other site 698965006383 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 698965006384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965006385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965006386 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 698965006387 active site 698965006388 catalytic site [active] 698965006389 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 698965006390 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 698965006391 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698965006392 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698965006393 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698965006394 Ligand Binding Site [chemical binding]; other site 698965006395 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698965006396 Ligand Binding Site [chemical binding]; other site 698965006397 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 698965006398 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698965006399 probable active site [active] 698965006400 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698965006401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965006402 Walker A/P-loop; other site 698965006403 ATP binding site [chemical binding]; other site 698965006404 Q-loop/lid; other site 698965006405 ABC transporter signature motif; other site 698965006406 Walker B; other site 698965006407 D-loop; other site 698965006408 H-loop/switch region; other site 698965006409 Predicted transcriptional regulators [Transcription]; Region: COG1725 698965006410 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698965006411 DNA-binding site [nucleotide binding]; DNA binding site 698965006412 LabA_like proteins; Region: LabA_like; cd06167 698965006413 putative metal binding site [ion binding]; other site 698965006414 Uncharacterized conserved protein [Function unknown]; Region: COG1432 698965006415 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698965006416 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698965006417 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698965006418 catalytic residues [active] 698965006419 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698965006420 metal-binding site [ion binding] 698965006421 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698965006422 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698965006423 metal-binding site [ion binding] 698965006424 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698965006425 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698965006426 benzoate transport; Region: 2A0115; TIGR00895 698965006427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965006428 putative substrate translocation pore; other site 698965006429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698965006430 replicative DNA helicase; Provisional; Region: PRK05636 698965006431 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 698965006432 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 698965006433 Walker A motif; other site 698965006434 ATP binding site [chemical binding]; other site 698965006435 Walker B motif; other site 698965006436 DNA binding loops [nucleotide binding] 698965006437 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 698965006438 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 698965006439 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 698965006440 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698965006441 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698965006442 dimer interface [polypeptide binding]; other site 698965006443 ssDNA binding site [nucleotide binding]; other site 698965006444 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698965006445 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 698965006446 Predicted integral membrane protein [Function unknown]; Region: COG5650 698965006447 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698965006448 Transglycosylase; Region: Transgly; pfam00912 698965006449 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698965006450 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698965006451 MarR family; Region: MarR_2; cl17246 698965006452 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698965006453 Ligand Binding Site [chemical binding]; other site 698965006454 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698965006455 Ligand Binding Site [chemical binding]; other site 698965006456 classical (c) SDRs; Region: SDR_c; cd05233 698965006457 short chain dehydrogenase; Provisional; Region: PRK08219 698965006458 NAD(P) binding site [chemical binding]; other site 698965006459 active site 698965006460 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698965006461 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698965006462 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 698965006463 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 698965006464 active site residue [active] 698965006465 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 698965006466 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698965006467 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 698965006468 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 698965006469 dimerization interface [polypeptide binding]; other site 698965006470 DPS ferroxidase diiron center [ion binding]; other site 698965006471 ion pore; other site 698965006472 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698965006473 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 698965006474 putative DNA binding site [nucleotide binding]; other site 698965006475 catalytic residue [active] 698965006476 putative H2TH interface [polypeptide binding]; other site 698965006477 putative catalytic residues [active] 698965006478 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698965006479 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698965006480 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 698965006481 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 698965006482 putative substrate binding site [chemical binding]; other site 698965006483 putative ATP binding site [chemical binding]; other site 698965006484 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 698965006485 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 698965006486 active site 698965006487 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698965006488 AAA domain; Region: AAA_31; pfam13614 698965006489 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698965006490 P-loop; other site 698965006491 Magnesium ion binding site [ion binding]; other site 698965006492 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698965006493 Magnesium ion binding site [ion binding]; other site 698965006494 Predicted helicase [General function prediction only]; Region: COG4889 698965006495 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698965006496 Divergent AAA domain; Region: AAA_4; pfam04326 698965006497 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698965006498 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698965006499 Divergent AAA domain; Region: AAA_4; pfam04326 698965006500 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698965006501 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 698965006502 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 698965006503 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698965006504 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698965006505 ATP binding site [chemical binding]; other site 698965006506 putative Mg++ binding site [ion binding]; other site 698965006507 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 698965006508 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698965006509 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 698965006510 HsdM N-terminal domain; Region: HsdM_N; pfam12161 698965006511 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 698965006512 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698965006513 Fic family protein [Function unknown]; Region: COG3177 698965006514 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698965006515 Fic/DOC family; Region: Fic; pfam02661 698965006516 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 698965006517 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 698965006518 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698965006519 active site 698965006520 HIGH motif; other site 698965006521 nucleotide binding site [chemical binding]; other site 698965006522 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698965006523 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698965006524 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698965006525 active site 698965006526 KMSKS motif; other site 698965006527 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 698965006528 tRNA binding surface [nucleotide binding]; other site 698965006529 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698965006530 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698965006531 Walker A/P-loop; other site 698965006532 ATP binding site [chemical binding]; other site 698965006533 Q-loop/lid; other site 698965006534 ABC transporter signature motif; other site 698965006535 Walker B; other site 698965006536 D-loop; other site 698965006537 H-loop/switch region; other site 698965006538 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698965006539 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698965006540 Histidine kinase; Region: HisKA_3; pfam07730 698965006541 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698965006542 ATP binding site [chemical binding]; other site 698965006543 G-X-G motif; other site 698965006544 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698965006545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698965006546 active site 698965006547 phosphorylation site [posttranslational modification] 698965006548 intermolecular recognition site; other site 698965006549 dimerization interface [polypeptide binding]; other site 698965006550 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698965006551 DNA binding residues [nucleotide binding] 698965006552 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698965006553 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698965006554 Predicted membrane protein [Function unknown]; Region: COG1511 698965006555 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698965006556 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698965006557 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698965006558 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698965006559 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698965006560 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698965006561 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 698965006562 NAD(P) binding site [chemical binding]; other site 698965006563 catalytic residues [active] 698965006564 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698965006565 active site 698965006566 phosphorylation site [posttranslational modification] 698965006567 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 698965006568 active site 698965006569 P-loop; other site 698965006570 phosphorylation site [posttranslational modification] 698965006571 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 698965006572 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 698965006573 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 698965006574 DAK2 domain; Region: Dak2; cl03685 698965006575 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 698965006576 active site 698965006577 active pocket/dimerization site; other site 698965006578 phosphorylation site [posttranslational modification] 698965006579 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698965006580 dimerization domain swap beta strand [polypeptide binding]; other site 698965006581 regulatory protein interface [polypeptide binding]; other site 698965006582 active site 698965006583 regulatory phosphorylation site [posttranslational modification]; other site 698965006584 Predicted ATPases [General function prediction only]; Region: COG1106 698965006585 Putative esterase; Region: Esterase; pfam00756 698965006586 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 698965006587 active site 698965006588 Cobalt transport protein; Region: CbiQ; cl00463 698965006589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965006590 ABC transporter signature motif; other site 698965006591 Walker B; other site 698965006592 D-loop; other site 698965006593 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698965006594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698965006595 Walker A/P-loop; other site 698965006596 ATP binding site [chemical binding]; other site 698965006597 Q-loop/lid; other site 698965006598 ABC transporter signature motif; other site 698965006599 Walker B; other site 698965006600 D-loop; other site 698965006601 H-loop/switch region; other site 698965006602 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 698965006603 active site 698965006604 catalytic residues [active] 698965006605 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 698965006606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 698965006607 hypothetical protein; Provisional; Region: PRK13663 698965006608 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698965006609 putative active site [active] 698965006610 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698965006611 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698965006612 SdpI/YhfL protein family; Region: SdpI; pfam13630 698965006613 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698965006614 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698965006615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698965006616 catalytic residue [active] 698965006617 anthranilate synthase component I; Provisional; Region: PRK13564 698965006618 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 698965006619 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698965006620 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698965006621 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698965006622 glutamine binding [chemical binding]; other site 698965006623 catalytic triad [active] 698965006624 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 698965006625 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698965006626 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698965006627 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 698965006628 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698965006629 active site 698965006630 ribulose/triose binding site [chemical binding]; other site 698965006631 phosphate binding site [ion binding]; other site 698965006632 substrate (anthranilate) binding pocket [chemical binding]; other site 698965006633 product (indole) binding pocket [chemical binding]; other site 698965006634 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 698965006635 active site 698965006636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 698965006637 pantoate--beta-alanine ligase; Region: panC; TIGR00018 698965006638 Pantoate-beta-alanine ligase; Region: PanC; cd00560 698965006639 active site 698965006640 ATP-binding site [chemical binding]; other site 698965006641 pantoate-binding site; other site 698965006642 HXXH motif; other site 698965006643 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 698965006644 oligomerization interface [polypeptide binding]; other site 698965006645 active site 698965006646 metal binding site [ion binding]; metal-binding site 698965006647 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698965006648 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698965006649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698965006650 catalytic residue [active] 698965006651 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 698965006652 substrate binding site [chemical binding]; other site 698965006653 active site 698965006654 catalytic residues [active] 698965006655 heterodimer interface [polypeptide binding]; other site 698965006656 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698965006657 iron-sulfur cluster [ion binding]; other site 698965006658 [2Fe-2S] cluster binding site [ion binding]; other site 698965006659 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 698965006660 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698965006661 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 698965006662 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 698965006663 hypothetical protein; Validated; Region: PRK00228 698965006664 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 698965006665 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 698965006666 active site 698965006667 NTP binding site [chemical binding]; other site 698965006668 metal binding triad [ion binding]; metal-binding site 698965006669 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 698965006670 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698965006671 Zn2+ binding site [ion binding]; other site 698965006672 Mg2+ binding site [ion binding]; other site 698965006673 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 698965006674 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698965006675 active site 698965006676 Ap6A binding site [chemical binding]; other site 698965006677 nudix motif; other site 698965006678 metal binding site [ion binding]; metal-binding site 698965006679 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 698965006680 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 698965006681 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 698965006682 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698965006683 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698965006684 DNA binding residues [nucleotide binding] 698965006685 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 698965006686 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698965006687 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698965006688 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698965006689 catalytic residues [active] 698965006690 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698965006691 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698965006692 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 698965006693 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 698965006694 active site 698965006695 metal binding site [ion binding]; metal-binding site 698965006696 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 698965006697 ParB-like nuclease domain; Region: ParBc; pfam02195 698965006698 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698965006699 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698965006700 P-loop; other site 698965006701 Magnesium ion binding site [ion binding]; other site 698965006702 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698965006703 Magnesium ion binding site [ion binding]; other site 698965006704 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 698965006705 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 698965006706 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 698965006707 ribonuclease P; Reviewed; Region: rnpA; PRK03459 698965006708 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399