-- dump date 20140619_050910 -- class Genbank::misc_feature -- table misc_feature_note -- id note 698967000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698967000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 698967000003 Walker A motif; other site 698967000004 ATP binding site [chemical binding]; other site 698967000005 Walker B motif; other site 698967000006 arginine finger; other site 698967000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 698967000008 DnaA box-binding interface [nucleotide binding]; other site 698967000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 698967000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 698967000011 putative DNA binding surface [nucleotide binding]; other site 698967000012 dimer interface [polypeptide binding]; other site 698967000013 beta-clamp/clamp loader binding surface; other site 698967000014 beta-clamp/translesion DNA polymerase binding surface; other site 698967000015 recombination protein F; Reviewed; Region: recF; PRK00064 698967000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 698967000017 Walker A/P-loop; other site 698967000018 ATP binding site [chemical binding]; other site 698967000019 Q-loop/lid; other site 698967000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967000021 ABC transporter signature motif; other site 698967000022 Walker B; other site 698967000023 D-loop; other site 698967000024 H-loop/switch region; other site 698967000025 hypothetical protein; Provisional; Region: PRK00111 698967000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 698967000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698967000028 ATP binding site [chemical binding]; other site 698967000029 Mg2+ binding site [ion binding]; other site 698967000030 G-X-G motif; other site 698967000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698967000032 anchoring element; other site 698967000033 dimer interface [polypeptide binding]; other site 698967000034 ATP binding site [chemical binding]; other site 698967000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 698967000036 active site 698967000037 putative metal-binding site [ion binding]; other site 698967000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698967000039 DNA gyrase subunit A; Validated; Region: PRK05560 698967000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 698967000041 CAP-like domain; other site 698967000042 active site 698967000043 primary dimer interface [polypeptide binding]; other site 698967000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698967000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698967000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698967000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698967000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698967000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698967000050 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 698967000051 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698967000052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698967000053 DNA-binding site [nucleotide binding]; DNA binding site 698967000054 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698967000055 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698967000056 L-lactate permease; Region: Lactate_perm; cl00701 698967000057 Cadherin repeat-like domain; Region: CA_like; cl15786 698967000058 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698967000059 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698967000060 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 698967000061 Walker A/P-loop; other site 698967000062 ATP binding site [chemical binding]; other site 698967000063 Q-loop/lid; other site 698967000064 ABC transporter signature motif; other site 698967000065 Walker B; other site 698967000066 D-loop; other site 698967000067 H-loop/switch region; other site 698967000068 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698967000069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967000070 Walker A/P-loop; other site 698967000071 ATP binding site [chemical binding]; other site 698967000072 Q-loop/lid; other site 698967000073 ABC transporter signature motif; other site 698967000074 Walker B; other site 698967000075 D-loop; other site 698967000076 H-loop/switch region; other site 698967000077 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698967000078 active site 698967000079 catalytic site [active] 698967000080 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698967000081 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698967000082 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 698967000083 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698967000084 putative ligand binding site [chemical binding]; other site 698967000085 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698967000086 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698967000087 TM-ABC transporter signature motif; other site 698967000088 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698967000089 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698967000090 Walker A/P-loop; other site 698967000091 ATP binding site [chemical binding]; other site 698967000092 Q-loop/lid; other site 698967000093 ABC transporter signature motif; other site 698967000094 Walker B; other site 698967000095 D-loop; other site 698967000096 H-loop/switch region; other site 698967000097 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698967000098 active site 698967000099 Integrase core domain; Region: rve_2; pfam13333 698967000100 Rhomboid family; Region: Rhomboid; pfam01694 698967000101 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 698967000102 ThiC-associated domain; Region: ThiC-associated; pfam13667 698967000103 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 698967000104 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698967000105 thiamine phosphate binding site [chemical binding]; other site 698967000106 active site 698967000107 pyrophosphate binding site [ion binding]; other site 698967000108 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698967000109 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 698967000110 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 698967000111 ThiS interaction site; other site 698967000112 putative active site [active] 698967000113 tetramer interface [polypeptide binding]; other site 698967000114 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 698967000115 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698967000116 ATP binding site [chemical binding]; other site 698967000117 substrate interface [chemical binding]; other site 698967000118 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698967000119 active site residue [active] 698967000120 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 698967000121 dimer interface [polypeptide binding]; other site 698967000122 substrate binding site [chemical binding]; other site 698967000123 ATP binding site [chemical binding]; other site 698967000124 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 698967000125 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 698967000126 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 698967000127 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 698967000128 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 698967000129 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698967000130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 698967000131 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698967000132 MULE transposase domain; Region: MULE; pfam10551 698967000133 putative septation inhibitor protein; Reviewed; Region: PRK00159 698967000134 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698967000135 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698967000136 active site 698967000137 ATP binding site [chemical binding]; other site 698967000138 substrate binding site [chemical binding]; other site 698967000139 activation loop (A-loop); other site 698967000140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698967000141 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698967000142 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698967000143 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698967000144 PASTA domain; Region: PASTA; pfam03793 698967000145 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698967000146 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698967000147 active site 698967000148 ATP binding site [chemical binding]; other site 698967000149 substrate binding site [chemical binding]; other site 698967000150 activation loop (A-loop); other site 698967000151 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698967000152 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698967000153 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698967000154 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 698967000155 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 698967000156 Protein phosphatase 2C; Region: PP2C; pfam00481 698967000157 active site 698967000158 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698967000159 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698967000160 phosphopeptide binding site; other site 698967000161 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 698967000162 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698967000163 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698967000164 phosphopeptide binding site; other site 698967000165 potential frameshift: common BLAST hit: gi|38233854|ref|NP_939621.1| transposase 698967000166 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698967000167 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698967000168 HTH-like domain; Region: HTH_21; pfam13276 698967000169 Integrase core domain; Region: rve; pfam00665 698967000170 Integrase core domain; Region: rve_2; pfam13333 698967000171 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 698967000172 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698967000173 potential frameshift: common BLAST hit: gi|172041642|ref|YP_001801356.1| transposase for insertion sequence 698967000174 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698967000175 Integrase core domain; Region: rve; pfam00665 698967000176 potential frameshift: common BLAST hit: gi|172041642|ref|YP_001801356.1| transposase for insertion sequence 698967000177 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698967000178 potential frameshift: common BLAST hit: gi|256832661|ref|YP_003161388.1| transposase IS204/IS1001/IS1096/IS1165 family protein 698967000179 Transposase; Region: DDE_Tnp_ISL3; pfam01610 698967000180 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 698967000181 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 698967000182 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698967000183 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 698967000184 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698967000185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967000186 Walker A/P-loop; other site 698967000187 ATP binding site [chemical binding]; other site 698967000188 Q-loop/lid; other site 698967000189 ABC transporter signature motif; other site 698967000190 Walker B; other site 698967000191 D-loop; other site 698967000192 H-loop/switch region; other site 698967000193 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698967000194 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698967000195 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967000196 Walker A/P-loop; other site 698967000197 ATP binding site [chemical binding]; other site 698967000198 Q-loop/lid; other site 698967000199 ABC transporter signature motif; other site 698967000200 Walker B; other site 698967000201 D-loop; other site 698967000202 H-loop/switch region; other site 698967000203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698967000204 S-adenosylmethionine binding site [chemical binding]; other site 698967000205 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698967000206 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 698967000207 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 698967000208 DNA-binding interface [nucleotide binding]; DNA binding site 698967000209 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698967000210 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698967000211 catalytic residues [active] 698967000212 catalytic nucleophile [active] 698967000213 Presynaptic Site I dimer interface [polypeptide binding]; other site 698967000214 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698967000215 Synaptic Flat tetramer interface [polypeptide binding]; other site 698967000216 Synaptic Site I dimer interface [polypeptide binding]; other site 698967000217 DNA binding site [nucleotide binding] 698967000218 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698967000219 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 698967000220 catalytic residues [active] 698967000221 catalytic nucleophile [active] 698967000222 Recombinase; Region: Recombinase; pfam07508 698967000223 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 698967000224 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698967000225 HTH-like domain; Region: HTH_21; pfam13276 698967000226 Integrase core domain; Region: rve_2; pfam13333 698967000227 potential frameshift: common BLAST hit: gi|172040624|ref|YP_001800338.1| transposase for insertion sequence 698967000228 potential frameshift: common BLAST hit: gi|172041642|ref|YP_001801356.1| transposase for insertion sequence 698967000229 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698967000230 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698967000231 Integrase core domain; Region: rve; pfam00665 698967000232 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 698967000233 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 698967000234 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698967000235 Walker A/P-loop; other site 698967000236 ATP binding site [chemical binding]; other site 698967000237 Q-loop/lid; other site 698967000238 ABC transporter signature motif; other site 698967000239 Walker B; other site 698967000240 D-loop; other site 698967000241 H-loop/switch region; other site 698967000242 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698967000243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698967000244 active site 698967000245 phosphorylation site [posttranslational modification] 698967000246 intermolecular recognition site; other site 698967000247 dimerization interface [polypeptide binding]; other site 698967000248 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698967000249 DNA binding residues [nucleotide binding] 698967000250 dimerization interface [polypeptide binding]; other site 698967000251 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698967000252 Histidine kinase; Region: HisKA_3; pfam07730 698967000253 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698967000254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698967000255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698967000256 dimer interface [polypeptide binding]; other site 698967000257 conserved gate region; other site 698967000258 putative PBP binding loops; other site 698967000259 ABC-ATPase subunit interface; other site 698967000260 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 698967000261 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 698967000262 Walker A/P-loop; other site 698967000263 ATP binding site [chemical binding]; other site 698967000264 Q-loop/lid; other site 698967000265 ABC transporter signature motif; other site 698967000266 Walker B; other site 698967000267 D-loop; other site 698967000268 H-loop/switch region; other site 698967000269 Anti-sigma-K factor rskA; Region: RskA; pfam10099 698967000270 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 698967000271 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698967000272 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698967000273 DNA binding residues [nucleotide binding] 698967000274 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698967000275 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698967000276 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 698967000277 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698967000278 catalytic residues [active] 698967000279 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 698967000280 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698967000281 DNA binding residues [nucleotide binding] 698967000282 dimer interface [polypeptide binding]; other site 698967000283 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 698967000284 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 698967000285 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 698967000286 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 698967000287 putative metal binding site [ion binding]; other site 698967000288 biotin synthase; Validated; Region: PRK06256 698967000289 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698967000290 FeS/SAM binding site; other site 698967000291 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698967000292 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 698967000293 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 698967000294 putative ligand binding residues [chemical binding]; other site 698967000295 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698967000296 ABC-ATPase subunit interface; other site 698967000297 dimer interface [polypeptide binding]; other site 698967000298 putative PBP binding regions; other site 698967000299 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698967000300 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698967000301 Walker A/P-loop; other site 698967000302 ATP binding site [chemical binding]; other site 698967000303 Q-loop/lid; other site 698967000304 ABC transporter signature motif; other site 698967000305 Walker B; other site 698967000306 D-loop; other site 698967000307 H-loop/switch region; other site 698967000308 Uncharacterized conserved protein [Function unknown]; Region: COG5646 698967000309 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 698967000310 DNA photolyase; Region: DNA_photolyase; pfam00875 698967000311 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 698967000312 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 698967000313 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 698967000314 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 698967000315 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 698967000316 Lipase (class 2); Region: Lipase_2; pfam01674 698967000317 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 698967000318 FMN binding site [chemical binding]; other site 698967000319 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 698967000320 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 698967000321 trimer interface [polypeptide binding]; other site 698967000322 putative metal binding site [ion binding]; other site 698967000323 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698967000324 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 698967000325 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 698967000326 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 698967000327 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698967000328 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698967000329 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 698967000330 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698967000331 MarR family; Region: MarR; pfam01047 698967000332 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 698967000333 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698967000334 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698967000335 hypothetical protein; Provisional; Region: PRK10621 698967000336 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698967000337 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 698967000338 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698967000339 ATP binding site [chemical binding]; other site 698967000340 putative Mg++ binding site [ion binding]; other site 698967000341 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698967000342 nucleotide binding region [chemical binding]; other site 698967000343 Helicase associated domain (HA2); Region: HA2; pfam04408 698967000344 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 698967000345 Maltose acetyltransferase; Region: Mac; pfam12464 698967000346 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 698967000347 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698967000348 putative trimer interface [polypeptide binding]; other site 698967000349 putative CoA binding site [chemical binding]; other site 698967000350 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698967000351 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 698967000352 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698967000353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698967000354 NAD(P) binding site [chemical binding]; other site 698967000355 active site 698967000356 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 698967000357 Helix-turn-helix domain; Region: HTH_28; pfam13518 698967000358 Integrase core domain; Region: rve_2; pfam13333 698967000359 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698967000360 Integrase core domain; Region: rve; pfam00665 698967000361 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 698967000362 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698967000363 RNA binding surface [nucleotide binding]; other site 698967000364 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698967000365 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698967000366 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698967000367 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 698967000368 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 698967000369 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 698967000370 active site 698967000371 Zn binding site [ion binding]; other site 698967000372 Protease prsW family; Region: PrsW-protease; pfam13367 698967000373 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698967000374 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 698967000375 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 698967000376 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 698967000377 short chain dehydrogenase; Provisional; Region: PRK07904 698967000378 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698967000379 NAD(P) binding site [chemical binding]; other site 698967000380 active site 698967000381 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698967000382 FAD binding domain; Region: FAD_binding_4; pfam01565 698967000383 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 698967000384 Predicted membrane protein [Function unknown]; Region: COG2246 698967000385 GtrA-like protein; Region: GtrA; pfam04138 698967000386 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698967000387 putative active site [active] 698967000388 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698967000389 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698967000390 active site 698967000391 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698967000392 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698967000393 intersubunit interface [polypeptide binding]; other site 698967000394 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698967000395 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698967000396 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698967000397 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698967000398 ABC-ATPase subunit interface; other site 698967000399 dimer interface [polypeptide binding]; other site 698967000400 putative PBP binding regions; other site 698967000401 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698967000402 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698967000403 ABC-ATPase subunit interface; other site 698967000404 dimer interface [polypeptide binding]; other site 698967000405 putative PBP binding regions; other site 698967000406 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698967000407 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698967000408 intersubunit interface [polypeptide binding]; other site 698967000409 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 698967000410 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 698967000411 Walker A/P-loop; other site 698967000412 ATP binding site [chemical binding]; other site 698967000413 Q-loop/lid; other site 698967000414 ABC transporter signature motif; other site 698967000415 Walker B; other site 698967000416 D-loop; other site 698967000417 H-loop/switch region; other site 698967000418 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 698967000419 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698967000420 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698967000421 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698967000422 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698967000423 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 698967000424 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 698967000425 NAD(P) binding site [chemical binding]; other site 698967000426 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 698967000427 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698967000428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698967000429 homodimer interface [polypeptide binding]; other site 698967000430 catalytic residue [active] 698967000431 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 698967000432 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 698967000433 transmembrane helices; other site 698967000434 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698967000435 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 698967000436 NodB motif; other site 698967000437 active site 698967000438 catalytic site [active] 698967000439 metal binding site [ion binding]; metal-binding site 698967000440 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698967000441 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698967000442 DNA-binding site [nucleotide binding]; DNA binding site 698967000443 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698967000444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698967000445 homodimer interface [polypeptide binding]; other site 698967000446 catalytic residue [active] 698967000447 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 698967000448 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 698967000449 active site 698967000450 multimer interface [polypeptide binding]; other site 698967000451 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 698967000452 predicted active site [active] 698967000453 catalytic triad [active] 698967000454 potential frameshift: common BLAST hit: gi|68535288|ref|YP_249993.1| transposase IS3510a 698967000455 potential frameshift: common BLAST hit: gi|68535288|ref|YP_249993.1| transposase IS3510a 698967000456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698967000457 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698967000458 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698967000459 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698967000460 active site 698967000461 catalytic site [active] 698967000462 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698967000463 active site 698967000464 catalytic site [active] 698967000465 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698967000466 metal ion-dependent adhesion site (MIDAS); other site 698967000467 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 698967000468 prephenate dehydrogenase; Validated; Region: PRK08507 698967000469 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 698967000470 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 698967000471 nucleoside/Zn binding site; other site 698967000472 dimer interface [polypeptide binding]; other site 698967000473 catalytic motif [active] 698967000474 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 698967000475 DNA binding residues [nucleotide binding] 698967000476 PIN domain; Region: PIN_3; pfam13470 698967000477 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 698967000478 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 698967000479 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 698967000480 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 698967000481 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 698967000482 active site 698967000483 HIGH motif; other site 698967000484 nucleotide binding site [chemical binding]; other site 698967000485 active site 698967000486 KMSKS motif; other site 698967000487 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 698967000488 fructuronate transporter; Provisional; Region: PRK10034; cl15264 698967000489 Shikimate kinase; Region: SKI; pfam01202 698967000490 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 698967000491 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 698967000492 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 698967000493 putative NAD(P) binding site [chemical binding]; other site 698967000494 catalytic Zn binding site [ion binding]; other site 698967000495 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 698967000496 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 698967000497 NADP binding site [chemical binding]; other site 698967000498 homodimer interface [polypeptide binding]; other site 698967000499 active site 698967000500 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 698967000501 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698967000502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698967000503 homodimer interface [polypeptide binding]; other site 698967000504 catalytic residue [active] 698967000505 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 698967000506 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 698967000507 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698967000508 Walker A motif; other site 698967000509 ATP binding site [chemical binding]; other site 698967000510 Walker B motif; other site 698967000511 arginine finger; other site 698967000512 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 698967000513 hypothetical protein; Validated; Region: PRK00153 698967000514 recombination protein RecR; Reviewed; Region: recR; PRK00076 698967000515 RecR protein; Region: RecR; pfam02132 698967000516 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 698967000517 putative active site [active] 698967000518 putative metal-binding site [ion binding]; other site 698967000519 tetramer interface [polypeptide binding]; other site 698967000520 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698967000521 catalytic triad [active] 698967000522 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 698967000523 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698967000524 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 698967000525 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 698967000526 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698967000527 active site 698967000528 catalytic site [active] 698967000529 substrate binding site [chemical binding]; other site 698967000530 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 698967000531 FMN binding site [chemical binding]; other site 698967000532 NADPH bind site [chemical binding]; other site 698967000533 2-isopropylmalate synthase; Validated; Region: PRK03739 698967000534 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 698967000535 active site 698967000536 catalytic residues [active] 698967000537 metal binding site [ion binding]; metal-binding site 698967000538 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 698967000539 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698967000540 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698967000541 DNA binding residues [nucleotide binding] 698967000542 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698967000543 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698967000544 active site 698967000545 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 698967000546 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698967000547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967000548 putative substrate translocation pore; other site 698967000549 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 698967000550 intersubunit interface [polypeptide binding]; other site 698967000551 active site 698967000552 catalytic residue [active] 698967000553 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 698967000554 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 698967000555 active site 698967000556 substrate binding site [chemical binding]; other site 698967000557 metal binding site [ion binding]; metal-binding site 698967000558 aspartate kinase; Reviewed; Region: PRK06635 698967000559 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 698967000560 putative nucleotide binding site [chemical binding]; other site 698967000561 putative catalytic residues [active] 698967000562 putative Mg ion binding site [ion binding]; other site 698967000563 putative aspartate binding site [chemical binding]; other site 698967000564 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 698967000565 putative allosteric regulatory site; other site 698967000566 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 698967000567 putative allosteric regulatory residue; other site 698967000568 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 698967000569 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698967000570 RNA polymerase sigma factor; Provisional; Region: PRK12535 698967000571 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698967000572 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698967000573 DNA binding residues [nucleotide binding] 698967000574 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 698967000575 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 698967000576 heme binding pocket [chemical binding]; other site 698967000577 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698967000578 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 698967000579 Walker A/P-loop; other site 698967000580 ATP binding site [chemical binding]; other site 698967000581 Q-loop/lid; other site 698967000582 ABC transporter signature motif; other site 698967000583 Walker B; other site 698967000584 D-loop; other site 698967000585 H-loop/switch region; other site 698967000586 TOBE domain; Region: TOBE_2; pfam08402 698967000587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698967000588 dimer interface [polypeptide binding]; other site 698967000589 conserved gate region; other site 698967000590 ABC-ATPase subunit interface; other site 698967000591 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698967000592 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 698967000593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967000594 putative substrate translocation pore; other site 698967000595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967000596 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698967000597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698967000598 active site 698967000599 phosphorylation site [posttranslational modification] 698967000600 intermolecular recognition site; other site 698967000601 dimerization interface [polypeptide binding]; other site 698967000602 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698967000603 DNA binding site [nucleotide binding] 698967000604 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698967000605 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698967000606 dimer interface [polypeptide binding]; other site 698967000607 phosphorylation site [posttranslational modification] 698967000608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698967000609 ATP binding site [chemical binding]; other site 698967000610 Mg2+ binding site [ion binding]; other site 698967000611 G-X-G motif; other site 698967000612 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 698967000613 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 698967000614 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 698967000615 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 698967000616 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698967000617 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 698967000618 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 698967000619 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698967000620 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 698967000621 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698967000622 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698967000623 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698967000624 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698967000625 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698967000626 putative active site [active] 698967000627 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 698967000628 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698967000629 putative active site [active] 698967000630 putative metal binding site [ion binding]; other site 698967000631 Yqey-like protein; Region: YqeY; pfam09424 698967000632 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698967000633 Transglycosylase; Region: Transgly; pfam00912 698967000634 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698967000635 PASTA domain; Region: PASTA; pfam03793 698967000636 Transcription factor WhiB; Region: Whib; pfam02467 698967000637 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 698967000638 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 698967000639 homotrimer interaction site [polypeptide binding]; other site 698967000640 putative active site [active] 698967000641 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698967000642 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698967000643 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698967000644 ligand binding site [chemical binding]; other site 698967000645 flexible hinge region; other site 698967000646 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698967000647 putative switch regulator; other site 698967000648 non-specific DNA interactions [nucleotide binding]; other site 698967000649 DNA binding site [nucleotide binding] 698967000650 sequence specific DNA binding site [nucleotide binding]; other site 698967000651 putative cAMP binding site [chemical binding]; other site 698967000652 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 698967000653 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698967000654 minor groove reading motif; other site 698967000655 helix-hairpin-helix signature motif; other site 698967000656 substrate binding pocket [chemical binding]; other site 698967000657 active site 698967000658 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 698967000659 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698967000660 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698967000661 catalytic residues [active] 698967000662 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 698967000663 putative active site [active] 698967000664 putative CoA binding site [chemical binding]; other site 698967000665 nudix motif; other site 698967000666 metal binding site [ion binding]; metal-binding site 698967000667 Colicin V production protein; Region: Colicin_V; pfam02674 698967000668 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 698967000669 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698967000670 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698967000671 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698967000672 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 698967000673 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698967000674 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698967000675 motif II; other site 698967000676 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 698967000677 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 698967000678 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 698967000679 ATP binding site [chemical binding]; other site 698967000680 Walker A motif; other site 698967000681 hexamer interface [polypeptide binding]; other site 698967000682 Walker B motif; other site 698967000683 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 698967000684 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 698967000685 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 698967000686 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 698967000687 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698967000688 ATP binding site [chemical binding]; other site 698967000689 putative Mg++ binding site [ion binding]; other site 698967000690 nucleotide binding region [chemical binding]; other site 698967000691 helicase superfamily c-terminal domain; Region: HELICc; smart00490 698967000692 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 698967000693 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698967000694 DNA-binding site [nucleotide binding]; DNA binding site 698967000695 RNA-binding motif; other site 698967000696 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698967000697 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698967000698 Walker A/P-loop; other site 698967000699 ATP binding site [chemical binding]; other site 698967000700 Q-loop/lid; other site 698967000701 ABC transporter signature motif; other site 698967000702 Walker B; other site 698967000703 D-loop; other site 698967000704 H-loop/switch region; other site 698967000705 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698967000706 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698967000707 Walker A/P-loop; other site 698967000708 ATP binding site [chemical binding]; other site 698967000709 Q-loop/lid; other site 698967000710 ABC transporter signature motif; other site 698967000711 Walker B; other site 698967000712 D-loop; other site 698967000713 H-loop/switch region; other site 698967000714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967000715 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698967000716 putative substrate translocation pore; other site 698967000717 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698967000718 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 698967000719 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698967000720 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 698967000721 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698967000722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698967000723 dimer interface [polypeptide binding]; other site 698967000724 conserved gate region; other site 698967000725 putative PBP binding loops; other site 698967000726 ABC-ATPase subunit interface; other site 698967000727 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698967000728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698967000729 NAD(P) binding site [chemical binding]; other site 698967000730 active site 698967000731 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 698967000732 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 698967000733 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 698967000734 active site 698967000735 interdomain interaction site; other site 698967000736 putative metal-binding site [ion binding]; other site 698967000737 nucleotide binding site [chemical binding]; other site 698967000738 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 698967000739 domain I; other site 698967000740 DNA binding groove [nucleotide binding] 698967000741 phosphate binding site [ion binding]; other site 698967000742 domain II; other site 698967000743 domain III; other site 698967000744 nucleotide binding site [chemical binding]; other site 698967000745 catalytic site [active] 698967000746 domain IV; other site 698967000747 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 698967000748 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698967000749 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698967000750 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698967000751 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698967000752 active site 698967000753 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 698967000754 Predicted membrane protein [Function unknown]; Region: COG1297 698967000755 putative oligopeptide transporter, OPT family; Region: TIGR00733 698967000756 Laminin G domain; Region: Laminin_G_2; pfam02210 698967000757 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698967000758 catalytic site [active] 698967000759 Asp-box motif; other site 698967000760 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698967000761 dimerization interface [polypeptide binding]; other site 698967000762 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698967000763 cyclase homology domain; Region: CHD; cd07302 698967000764 nucleotidyl binding site; other site 698967000765 metal binding site [ion binding]; metal-binding site 698967000766 dimer interface [polypeptide binding]; other site 698967000767 DNA polymerase III subunit delta'; Validated; Region: PRK07940 698967000768 DNA polymerase III subunit delta'; Validated; Region: PRK08485 698967000769 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 698967000770 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698967000771 MULE transposase domain; Region: MULE; pfam10551 698967000772 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698967000773 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698967000774 Fic family protein [Function unknown]; Region: COG3177 698967000775 Fic/DOC family; Region: Fic; pfam02661 698967000776 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698967000777 Trypsin; Region: Trypsin; pfam00089 698967000778 active site 698967000779 HTH-like domain; Region: HTH_21; pfam13276 698967000780 Integrase core domain; Region: rve; pfam00665 698967000781 Transposase; Region: HTH_Tnp_1; cl17663 698967000782 acyl-CoA synthetase; Validated; Region: PRK07788 698967000783 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698967000784 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698967000785 acyl-activating enzyme (AAE) consensus motif; other site 698967000786 acyl-activating enzyme (AAE) consensus motif; other site 698967000787 AMP binding site [chemical binding]; other site 698967000788 active site 698967000789 CoA binding site [chemical binding]; other site 698967000790 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 698967000791 active site 698967000792 catalytic triad [active] 698967000793 oxyanion hole [active] 698967000794 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 698967000795 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 698967000796 substrate binding site; other site 698967000797 tetramer interface; other site 698967000798 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 698967000799 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 698967000800 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 698967000801 NADP binding site [chemical binding]; other site 698967000802 active site 698967000803 putative substrate binding site [chemical binding]; other site 698967000804 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 698967000805 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 698967000806 NAD binding site [chemical binding]; other site 698967000807 substrate binding site [chemical binding]; other site 698967000808 homodimer interface [polypeptide binding]; other site 698967000809 active site 698967000810 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 698967000811 Zn binding site [ion binding]; other site 698967000812 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 698967000813 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698967000814 Putative esterase; Region: Esterase; pfam00756 698967000815 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 698967000816 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 698967000817 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698967000818 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698967000819 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698967000820 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698967000821 non-specific DNA binding site [nucleotide binding]; other site 698967000822 salt bridge; other site 698967000823 sequence-specific DNA binding site [nucleotide binding]; other site 698967000824 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 698967000825 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698967000826 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 698967000827 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 698967000828 putative Iron-sulfur protein interface [polypeptide binding]; other site 698967000829 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 698967000830 proximal heme binding site [chemical binding]; other site 698967000831 distal heme binding site [chemical binding]; other site 698967000832 putative dimer interface [polypeptide binding]; other site 698967000833 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 698967000834 L-aspartate oxidase; Provisional; Region: PRK06175 698967000835 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 698967000836 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 698967000837 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 698967000838 Predicted membrane protein [Function unknown]; Region: COG2733 698967000839 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 698967000840 Class I aldolases; Region: Aldolase_Class_I; cd00945 698967000841 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698967000842 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 698967000843 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698967000844 FeS/SAM binding site; other site 698967000845 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 698967000846 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698967000847 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 698967000848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698967000849 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 698967000850 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 698967000851 FAD binding domain; Region: FAD_binding_4; pfam01565 698967000852 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 698967000853 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698967000854 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698967000855 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698967000856 acyl-activating enzyme (AAE) consensus motif; other site 698967000857 AMP binding site [chemical binding]; other site 698967000858 active site 698967000859 CoA binding site [chemical binding]; other site 698967000860 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698967000861 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698967000862 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698967000863 acyl-activating enzyme (AAE) consensus motif; other site 698967000864 AMP binding site [chemical binding]; other site 698967000865 active site 698967000866 CoA binding site [chemical binding]; other site 698967000867 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 698967000868 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 698967000869 putative ADP-binding pocket [chemical binding]; other site 698967000870 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698967000871 catalytic core [active] 698967000872 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698967000873 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698967000874 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698967000875 dimer interface [polypeptide binding]; other site 698967000876 phosphorylation site [posttranslational modification] 698967000877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698967000878 ATP binding site [chemical binding]; other site 698967000879 Mg2+ binding site [ion binding]; other site 698967000880 G-X-G motif; other site 698967000881 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698967000882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698967000883 active site 698967000884 phosphorylation site [posttranslational modification] 698967000885 intermolecular recognition site; other site 698967000886 dimerization interface [polypeptide binding]; other site 698967000887 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698967000888 DNA binding site [nucleotide binding] 698967000889 exopolyphosphatase; Region: exo_poly_only; TIGR03706 698967000890 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698967000891 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 698967000892 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 698967000893 DNA binding domain, excisionase family; Region: excise; TIGR01764 698967000894 Thioredoxin; Region: Thioredoxin_4; cl17273 698967000895 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698967000896 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698967000897 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 698967000898 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698967000899 motif II; other site 698967000900 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 698967000901 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 698967000902 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 698967000903 tRNA; other site 698967000904 putative tRNA binding site [nucleotide binding]; other site 698967000905 putative NADP binding site [chemical binding]; other site 698967000906 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 698967000907 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 698967000908 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 698967000909 domain interfaces; other site 698967000910 active site 698967000911 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 698967000912 active site 698967000913 homodimer interface [polypeptide binding]; other site 698967000914 SAM binding site [chemical binding]; other site 698967000915 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 698967000916 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 698967000917 active site 698967000918 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 698967000919 dimer interface [polypeptide binding]; other site 698967000920 active site 698967000921 Schiff base residues; other site 698967000922 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 698967000923 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698967000924 Predicted membrane protein [Function unknown]; Region: COG2311 698967000925 Protein of unknown function (DUF418); Region: DUF418; pfam04235 698967000926 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 698967000927 substrate binding site [chemical binding]; other site 698967000928 active site 698967000929 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 698967000930 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 698967000931 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698967000932 inhibitor-cofactor binding pocket; inhibition site 698967000933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698967000934 catalytic residue [active] 698967000935 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698967000936 catalytic core [active] 698967000937 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698967000938 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698967000939 catalytic residues [active] 698967000940 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698967000941 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698967000942 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 698967000943 ResB-like family; Region: ResB; pfam05140 698967000944 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 698967000945 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698967000946 dimerization interface [polypeptide binding]; other site 698967000947 putative DNA binding site [nucleotide binding]; other site 698967000948 putative Zn2+ binding site [ion binding]; other site 698967000949 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 698967000950 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 698967000951 UbiA prenyltransferase family; Region: UbiA; pfam01040 698967000952 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698967000953 active site 698967000954 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698967000955 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 698967000956 acyl-activating enzyme (AAE) consensus motif; other site 698967000957 AMP binding site [chemical binding]; other site 698967000958 active site 698967000959 CoA binding site [chemical binding]; other site 698967000960 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 698967000961 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698967000962 substrate binding site [chemical binding]; other site 698967000963 oxyanion hole (OAH) forming residues; other site 698967000964 trimer interface [polypeptide binding]; other site 698967000965 O-succinylbenzoate synthase; Provisional; Region: PRK02901 698967000966 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 698967000967 active site 698967000968 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 698967000969 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 698967000970 dimer interface [polypeptide binding]; other site 698967000971 tetramer interface [polypeptide binding]; other site 698967000972 PYR/PP interface [polypeptide binding]; other site 698967000973 TPP binding site [chemical binding]; other site 698967000974 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 698967000975 TPP-binding site; other site 698967000976 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 698967000977 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698967000978 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 698967000979 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 698967000980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698967000981 S-adenosylmethionine binding site [chemical binding]; other site 698967000982 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 698967000983 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 698967000984 NAD binding site [chemical binding]; other site 698967000985 dimer interface [polypeptide binding]; other site 698967000986 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698967000987 substrate binding site [chemical binding]; other site 698967000988 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 698967000989 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698967000990 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698967000991 substrate binding pocket [chemical binding]; other site 698967000992 chain length determination region; other site 698967000993 substrate-Mg2+ binding site; other site 698967000994 catalytic residues [active] 698967000995 aspartate-rich region 1; other site 698967000996 active site lid residues [active] 698967000997 aspartate-rich region 2; other site 698967000998 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 698967000999 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 698967001000 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 698967001001 putative homodimer interface [polypeptide binding]; other site 698967001002 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 698967001003 heterodimer interface [polypeptide binding]; other site 698967001004 homodimer interface [polypeptide binding]; other site 698967001005 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 698967001006 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 698967001007 23S rRNA interface [nucleotide binding]; other site 698967001008 L7/L12 interface [polypeptide binding]; other site 698967001009 putative thiostrepton binding site; other site 698967001010 L25 interface [polypeptide binding]; other site 698967001011 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 698967001012 mRNA/rRNA interface [nucleotide binding]; other site 698967001013 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 698967001014 23S rRNA interface [nucleotide binding]; other site 698967001015 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 698967001016 50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157 698967001017 L11 interface [polypeptide binding]; other site 698967001018 putative EF-Tu interaction site [polypeptide binding]; other site 698967001019 putative EF-G interaction site [polypeptide binding]; other site 698967001020 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 698967001021 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698967001022 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698967001023 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698967001024 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698967001025 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698967001026 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 698967001027 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698967001028 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698967001029 ABC-ATPase subunit interface; other site 698967001030 dimer interface [polypeptide binding]; other site 698967001031 putative PBP binding regions; other site 698967001032 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698967001033 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698967001034 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698967001035 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698967001036 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 698967001037 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 698967001038 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 698967001039 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 698967001040 RPB1 interaction site [polypeptide binding]; other site 698967001041 RPB10 interaction site [polypeptide binding]; other site 698967001042 RPB11 interaction site [polypeptide binding]; other site 698967001043 RPB3 interaction site [polypeptide binding]; other site 698967001044 RPB12 interaction site [polypeptide binding]; other site 698967001045 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 698967001046 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 698967001047 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 698967001048 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 698967001049 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 698967001050 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698967001051 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 698967001052 G-loop; other site 698967001053 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698967001054 DNA binding site [nucleotide binding] 698967001055 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 698967001056 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698967001057 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698967001058 Walker A/P-loop; other site 698967001059 ATP binding site [chemical binding]; other site 698967001060 Q-loop/lid; other site 698967001061 ABC transporter signature motif; other site 698967001062 Walker B; other site 698967001063 D-loop; other site 698967001064 H-loop/switch region; other site 698967001065 potential frameshift: common BLAST hit: gi|19554259|ref|NP_602261.1| helicase 698967001066 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 698967001067 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698967001068 ATP binding site [chemical binding]; other site 698967001069 putative Mg++ binding site [ion binding]; other site 698967001070 Predicted helicase [General function prediction only]; Region: COG4889 698967001071 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698967001072 nucleotide binding region [chemical binding]; other site 698967001073 ATP-binding site [chemical binding]; other site 698967001074 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698967001075 Histidine kinase; Region: HisKA_3; pfam07730 698967001076 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698967001077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698967001078 active site 698967001079 phosphorylation site [posttranslational modification] 698967001080 intermolecular recognition site; other site 698967001081 dimerization interface [polypeptide binding]; other site 698967001082 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698967001083 DNA binding residues [nucleotide binding] 698967001084 dimerization interface [polypeptide binding]; other site 698967001085 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698967001086 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698967001087 Walker A/P-loop; other site 698967001088 ATP binding site [chemical binding]; other site 698967001089 Q-loop/lid; other site 698967001090 ABC transporter signature motif; other site 698967001091 Walker B; other site 698967001092 D-loop; other site 698967001093 H-loop/switch region; other site 698967001094 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 698967001095 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698967001096 TIGR03943 family protein; Region: TIGR03943 698967001097 Predicted permeases [General function prediction only]; Region: COG0701 698967001098 Radical SAM superfamily; Region: Radical_SAM; pfam04055 698967001099 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698967001100 FeS/SAM binding site; other site 698967001101 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 698967001102 Class III ribonucleotide reductase; Region: RNR_III; cd01675 698967001103 effector binding site; other site 698967001104 active site 698967001105 Zn binding site [ion binding]; other site 698967001106 glycine loop; other site 698967001107 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 698967001108 S17 interaction site [polypeptide binding]; other site 698967001109 S8 interaction site; other site 698967001110 16S rRNA interaction site [nucleotide binding]; other site 698967001111 streptomycin interaction site [chemical binding]; other site 698967001112 23S rRNA interaction site [nucleotide binding]; other site 698967001113 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 698967001114 30S ribosomal protein S7; Validated; Region: PRK05302 698967001115 elongation factor G; Reviewed; Region: PRK00007 698967001116 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 698967001117 G1 box; other site 698967001118 putative GEF interaction site [polypeptide binding]; other site 698967001119 GTP/Mg2+ binding site [chemical binding]; other site 698967001120 Switch I region; other site 698967001121 G2 box; other site 698967001122 G3 box; other site 698967001123 Switch II region; other site 698967001124 G4 box; other site 698967001125 G5 box; other site 698967001126 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 698967001127 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 698967001128 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 698967001129 elongation factor Tu; Reviewed; Region: PRK00049 698967001130 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 698967001131 G1 box; other site 698967001132 GEF interaction site [polypeptide binding]; other site 698967001133 GTP/Mg2+ binding site [chemical binding]; other site 698967001134 Switch I region; other site 698967001135 G2 box; other site 698967001136 G3 box; other site 698967001137 Switch II region; other site 698967001138 G4 box; other site 698967001139 G5 box; other site 698967001140 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 698967001141 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 698967001142 Antibiotic Binding Site [chemical binding]; other site 698967001143 Predicted membrane protein [Function unknown]; Region: COG2323 698967001144 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 698967001145 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 698967001146 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 698967001147 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 698967001148 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 698967001149 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 698967001150 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 698967001151 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 698967001152 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 698967001153 putative translocon binding site; other site 698967001154 protein-rRNA interface [nucleotide binding]; other site 698967001155 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 698967001156 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 698967001157 G-X-X-G motif; other site 698967001158 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 698967001159 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 698967001160 23S rRNA interface [nucleotide binding]; other site 698967001161 5S rRNA interface [nucleotide binding]; other site 698967001162 putative antibiotic binding site [chemical binding]; other site 698967001163 L25 interface [polypeptide binding]; other site 698967001164 L27 interface [polypeptide binding]; other site 698967001165 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 698967001166 putative translocon interaction site; other site 698967001167 23S rRNA interface [nucleotide binding]; other site 698967001168 signal recognition particle (SRP54) interaction site; other site 698967001169 L23 interface [polypeptide binding]; other site 698967001170 trigger factor interaction site; other site 698967001171 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 698967001172 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698967001173 HlyD family secretion protein; Region: HlyD_3; pfam13437 698967001174 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698967001175 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698967001176 Walker A/P-loop; other site 698967001177 ATP binding site [chemical binding]; other site 698967001178 Q-loop/lid; other site 698967001179 ABC transporter signature motif; other site 698967001180 Walker B; other site 698967001181 D-loop; other site 698967001182 H-loop/switch region; other site 698967001183 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698967001184 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698967001185 FtsX-like permease family; Region: FtsX; pfam02687 698967001186 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 698967001187 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 698967001188 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 698967001189 RNA binding site [nucleotide binding]; other site 698967001190 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 698967001191 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 698967001192 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 698967001193 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 698967001194 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 698967001195 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698967001196 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698967001197 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698967001198 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698967001199 active site 698967001200 homotetramer interface [polypeptide binding]; other site 698967001201 homodimer interface [polypeptide binding]; other site 698967001202 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 698967001203 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698967001204 ATP binding site [chemical binding]; other site 698967001205 substrate interface [chemical binding]; other site 698967001206 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698967001207 active site residue [active] 698967001208 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698967001209 MPT binding site; other site 698967001210 trimer interface [polypeptide binding]; other site 698967001211 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 698967001212 MoaE homodimer interface [polypeptide binding]; other site 698967001213 MoaD interaction [polypeptide binding]; other site 698967001214 active site residues [active] 698967001215 Predicted transcriptional regulator [Transcription]; Region: COG2345 698967001216 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 698967001217 DNA binding residues [nucleotide binding] 698967001218 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698967001219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698967001220 dimer interface [polypeptide binding]; other site 698967001221 conserved gate region; other site 698967001222 putative PBP binding loops; other site 698967001223 ABC-ATPase subunit interface; other site 698967001224 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967001225 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 698967001226 Walker A/P-loop; other site 698967001227 ATP binding site [chemical binding]; other site 698967001228 Q-loop/lid; other site 698967001229 ABC transporter signature motif; other site 698967001230 Walker B; other site 698967001231 D-loop; other site 698967001232 H-loop/switch region; other site 698967001233 TOBE domain; Region: TOBE; cl01440 698967001234 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 698967001235 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698967001236 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 698967001237 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 698967001238 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 698967001239 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 698967001240 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 698967001241 [4Fe-4S] binding site [ion binding]; other site 698967001242 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698967001243 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698967001244 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698967001245 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 698967001246 molybdopterin cofactor binding site; other site 698967001247 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 698967001248 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 698967001249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967001250 putative substrate translocation pore; other site 698967001251 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698967001252 MPT binding site; other site 698967001253 trimer interface [polypeptide binding]; other site 698967001254 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 698967001255 GTP binding site; other site 698967001256 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 698967001257 trimer interface [polypeptide binding]; other site 698967001258 dimer interface [polypeptide binding]; other site 698967001259 putative active site [active] 698967001260 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698967001261 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698967001262 dimer interface [polypeptide binding]; other site 698967001263 putative functional site; other site 698967001264 putative MPT binding site; other site 698967001265 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 698967001266 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698967001267 FeS/SAM binding site; other site 698967001268 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 698967001269 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698967001270 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698967001271 inhibitor site; inhibition site 698967001272 active site 698967001273 dimer interface [polypeptide binding]; other site 698967001274 catalytic residue [active] 698967001275 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698967001276 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698967001277 Walker A/P-loop; other site 698967001278 ATP binding site [chemical binding]; other site 698967001279 Q-loop/lid; other site 698967001280 ABC transporter signature motif; other site 698967001281 Walker B; other site 698967001282 D-loop; other site 698967001283 H-loop/switch region; other site 698967001284 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698967001285 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698967001286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698967001287 dimer interface [polypeptide binding]; other site 698967001288 conserved gate region; other site 698967001289 putative PBP binding loops; other site 698967001290 ABC-ATPase subunit interface; other site 698967001291 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698967001292 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698967001293 Walker A/P-loop; other site 698967001294 ATP binding site [chemical binding]; other site 698967001295 Q-loop/lid; other site 698967001296 ABC transporter signature motif; other site 698967001297 Walker B; other site 698967001298 D-loop; other site 698967001299 H-loop/switch region; other site 698967001300 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698967001301 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698967001302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698967001303 dimer interface [polypeptide binding]; other site 698967001304 conserved gate region; other site 698967001305 putative PBP binding loops; other site 698967001306 ABC-ATPase subunit interface; other site 698967001307 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 698967001308 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698967001309 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698967001310 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698967001311 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698967001312 DNA-binding site [nucleotide binding]; DNA binding site 698967001313 FCD domain; Region: FCD; pfam07729 698967001314 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698967001315 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698967001316 nucleotide binding site [chemical binding]; other site 698967001317 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 698967001318 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 698967001319 putative active site cavity [active] 698967001320 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 698967001321 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 698967001322 active site 698967001323 dimer interface [polypeptide binding]; other site 698967001324 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698967001325 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 698967001326 active site 698967001327 trimer interface [polypeptide binding]; other site 698967001328 allosteric site; other site 698967001329 active site lid [active] 698967001330 hexamer (dimer of trimers) interface [polypeptide binding]; other site 698967001331 Htaa; Region: HtaA; pfam04213 698967001332 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 698967001333 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 698967001334 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698967001335 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698967001336 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 698967001337 5S rRNA interface [nucleotide binding]; other site 698967001338 L27 interface [polypeptide binding]; other site 698967001339 23S rRNA interface [nucleotide binding]; other site 698967001340 L5 interface [polypeptide binding]; other site 698967001341 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 698967001342 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 698967001343 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 698967001344 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 698967001345 23S rRNA binding site [nucleotide binding]; other site 698967001346 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 698967001347 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 698967001348 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 698967001349 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 698967001350 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698967001351 active site 698967001352 catalytic site [active] 698967001353 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698967001354 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698967001355 active site 698967001356 catalytic site [active] 698967001357 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 698967001358 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698967001359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698967001360 dimer interface [polypeptide binding]; other site 698967001361 conserved gate region; other site 698967001362 putative PBP binding loops; other site 698967001363 ABC-ATPase subunit interface; other site 698967001364 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698967001365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698967001366 dimer interface [polypeptide binding]; other site 698967001367 conserved gate region; other site 698967001368 putative PBP binding loops; other site 698967001369 ABC-ATPase subunit interface; other site 698967001370 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 698967001371 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698967001372 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698967001373 Walker A/P-loop; other site 698967001374 ATP binding site [chemical binding]; other site 698967001375 Q-loop/lid; other site 698967001376 ABC transporter signature motif; other site 698967001377 Walker B; other site 698967001378 D-loop; other site 698967001379 H-loop/switch region; other site 698967001380 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 698967001381 SecY translocase; Region: SecY; pfam00344 698967001382 adenylate kinase; Reviewed; Region: adk; PRK00279 698967001383 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 698967001384 AMP-binding site [chemical binding]; other site 698967001385 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 698967001386 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698967001387 active site 698967001388 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698967001389 catalytic site [active] 698967001390 BNR repeat-like domain; Region: BNR_2; pfam13088 698967001391 Asp-box motif; other site 698967001392 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698967001393 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 698967001394 rRNA binding site [nucleotide binding]; other site 698967001395 predicted 30S ribosome binding site; other site 698967001396 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 698967001397 30S ribosomal protein S13; Region: bact_S13; TIGR03631 698967001398 30S ribosomal protein S11; Validated; Region: PRK05309 698967001399 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 698967001400 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 698967001401 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698967001402 RNA binding surface [nucleotide binding]; other site 698967001403 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 698967001404 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 698967001405 alphaNTD - beta interaction site [polypeptide binding]; other site 698967001406 alphaNTD homodimer interface [polypeptide binding]; other site 698967001407 alphaNTD - beta' interaction site [polypeptide binding]; other site 698967001408 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 698967001409 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 698967001410 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 698967001411 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 698967001412 dimerization interface 3.5A [polypeptide binding]; other site 698967001413 active site 698967001414 Protein of unknown function (DUF690); Region: DUF690; cl04939 698967001415 TIGR02611 family protein; Region: TIGR02611 698967001416 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 698967001417 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 698967001418 active site 698967001419 catalytic residues [active] 698967001420 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 698967001421 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 698967001422 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698967001423 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 698967001424 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698967001425 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698967001426 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 698967001427 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 698967001428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 698967001429 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 698967001430 23S rRNA interface [nucleotide binding]; other site 698967001431 L3 interface [polypeptide binding]; other site 698967001432 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 698967001433 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 698967001434 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 698967001435 active site 698967001436 substrate binding site [chemical binding]; other site 698967001437 metal binding site [ion binding]; metal-binding site 698967001438 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 698967001439 alanine racemase; Reviewed; Region: alr; PRK00053 698967001440 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 698967001441 active site 698967001442 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698967001443 dimer interface [polypeptide binding]; other site 698967001444 substrate binding site [chemical binding]; other site 698967001445 catalytic residues [active] 698967001446 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 698967001447 Predicted permease [General function prediction only]; Region: COG2985 698967001448 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698967001449 TrkA-C domain; Region: TrkA_C; pfam02080 698967001450 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698967001451 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698967001452 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 698967001453 Glycoprotease family; Region: Peptidase_M22; pfam00814 698967001454 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698967001455 Coenzyme A binding pocket [chemical binding]; other site 698967001456 UGMP family protein; Validated; Region: PRK09604 698967001457 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 698967001458 oligomerisation interface [polypeptide binding]; other site 698967001459 mobile loop; other site 698967001460 roof hairpin; other site 698967001461 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698967001462 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698967001463 ring oligomerisation interface [polypeptide binding]; other site 698967001464 ATP/Mg binding site [chemical binding]; other site 698967001465 stacking interactions; other site 698967001466 hinge regions; other site 698967001467 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 698967001468 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698967001469 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698967001470 DNA binding residues [nucleotide binding] 698967001471 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 698967001472 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698967001473 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 698967001474 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 698967001475 active site 698967001476 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 698967001477 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698967001478 phosphate binding site [ion binding]; other site 698967001479 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698967001480 siderophore binding site; other site 698967001481 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698967001482 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698967001483 dimer interface [polypeptide binding]; other site 698967001484 putative PBP binding regions; other site 698967001485 ABC-ATPase subunit interface; other site 698967001486 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698967001487 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698967001488 ABC-ATPase subunit interface; other site 698967001489 dimer interface [polypeptide binding]; other site 698967001490 putative PBP binding regions; other site 698967001491 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698967001492 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698967001493 Walker A/P-loop; other site 698967001494 ATP binding site [chemical binding]; other site 698967001495 Q-loop/lid; other site 698967001496 ABC transporter signature motif; other site 698967001497 Walker B; other site 698967001498 D-loop; other site 698967001499 H-loop/switch region; other site 698967001500 IucA / IucC family; Region: IucA_IucC; pfam04183 698967001501 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698967001502 IucA / IucC family; Region: IucA_IucC; pfam04183 698967001503 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698967001504 H+ Antiporter protein; Region: 2A0121; TIGR00900 698967001505 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 698967001506 EamA-like transporter family; Region: EamA; pfam00892 698967001507 GMP synthase; Reviewed; Region: guaA; PRK00074 698967001508 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 698967001509 AMP/PPi binding site [chemical binding]; other site 698967001510 candidate oxyanion hole; other site 698967001511 catalytic triad [active] 698967001512 potential glutamine specificity residues [chemical binding]; other site 698967001513 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 698967001514 ATP Binding subdomain [chemical binding]; other site 698967001515 Ligand Binding sites [chemical binding]; other site 698967001516 Dimerization subdomain; other site 698967001517 PspC domain; Region: PspC; pfam04024 698967001518 PspC domain; Region: PspC; pfam04024 698967001519 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698967001520 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698967001521 ATP binding site [chemical binding]; other site 698967001522 Mg2+ binding site [ion binding]; other site 698967001523 G-X-G motif; other site 698967001524 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698967001525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698967001526 active site 698967001527 phosphorylation site [posttranslational modification] 698967001528 intermolecular recognition site; other site 698967001529 dimerization interface [polypeptide binding]; other site 698967001530 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698967001531 DNA binding residues [nucleotide binding] 698967001532 dimerization interface [polypeptide binding]; other site 698967001533 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698967001534 intersubunit interface [polypeptide binding]; other site 698967001535 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698967001536 DNA Polymerase Y-family; Region: PolY_like; cd03468 698967001537 active site 698967001538 DNA binding site [nucleotide binding] 698967001539 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 698967001540 putative dimer interface [polypeptide binding]; other site 698967001541 putative [2Fe-2S] cluster binding site [ion binding]; other site 698967001542 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698967001543 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698967001544 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698967001545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698967001546 dimer interface [polypeptide binding]; other site 698967001547 conserved gate region; other site 698967001548 ABC-ATPase subunit interface; other site 698967001549 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 698967001550 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 698967001551 Walker A/P-loop; other site 698967001552 ATP binding site [chemical binding]; other site 698967001553 Q-loop/lid; other site 698967001554 ABC transporter signature motif; other site 698967001555 Walker B; other site 698967001556 D-loop; other site 698967001557 H-loop/switch region; other site 698967001558 NIL domain; Region: NIL; cl09633 698967001559 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698967001560 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 698967001561 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698967001562 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 698967001563 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 698967001564 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 698967001565 active site 698967001566 PHP Thumb interface [polypeptide binding]; other site 698967001567 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698967001568 generic binding surface II; other site 698967001569 generic binding surface I; other site 698967001570 Uncharacterized conserved protein [Function unknown]; Region: COG3402 698967001571 Predicted membrane protein [Function unknown]; Region: COG3428 698967001572 Bacterial PH domain; Region: DUF304; pfam03703 698967001573 Bacterial PH domain; Region: DUF304; pfam03703 698967001574 Bacterial PH domain; Region: DUF304; pfam03703 698967001575 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698967001576 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698967001577 intersubunit interface [polypeptide binding]; other site 698967001578 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698967001579 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698967001580 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698967001581 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698967001582 dimer interface [polypeptide binding]; other site 698967001583 putative PBP binding regions; other site 698967001584 ABC-ATPase subunit interface; other site 698967001585 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698967001586 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698967001587 ABC-ATPase subunit interface; other site 698967001588 dimer interface [polypeptide binding]; other site 698967001589 putative PBP binding regions; other site 698967001590 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698967001591 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698967001592 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698967001593 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 698967001594 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 698967001595 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 698967001596 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 698967001597 homodimer interface [polypeptide binding]; other site 698967001598 NADP binding site [chemical binding]; other site 698967001599 substrate binding site [chemical binding]; other site 698967001600 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 698967001601 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698967001602 active site 698967001603 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 698967001604 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 698967001605 Htaa; Region: HtaA; pfam04213 698967001606 Htaa; Region: HtaA; pfam04213 698967001607 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698967001608 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698967001609 intersubunit interface [polypeptide binding]; other site 698967001610 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698967001611 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698967001612 ABC-ATPase subunit interface; other site 698967001613 dimer interface [polypeptide binding]; other site 698967001614 putative PBP binding regions; other site 698967001615 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 698967001616 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698967001617 Walker A/P-loop; other site 698967001618 ATP binding site [chemical binding]; other site 698967001619 Q-loop/lid; other site 698967001620 ABC transporter signature motif; other site 698967001621 Walker B; other site 698967001622 D-loop; other site 698967001623 H-loop/switch region; other site 698967001624 Htaa; Region: HtaA; pfam04213 698967001625 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 698967001626 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698967001627 homodimer interface [polypeptide binding]; other site 698967001628 substrate-cofactor binding pocket; other site 698967001629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698967001630 catalytic residue [active] 698967001631 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 698967001632 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 698967001633 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698967001634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967001635 putative substrate translocation pore; other site 698967001636 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698967001637 putative catalytic site [active] 698967001638 putative metal binding site [ion binding]; other site 698967001639 putative phosphate binding site [ion binding]; other site 698967001640 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 698967001641 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 698967001642 active site 698967001643 HIGH motif; other site 698967001644 dimer interface [polypeptide binding]; other site 698967001645 KMSKS motif; other site 698967001646 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 698967001647 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698967001648 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698967001649 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698967001650 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698967001651 NlpC/P60 family; Region: NLPC_P60; pfam00877 698967001652 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698967001653 active site 698967001654 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698967001655 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698967001656 non-specific DNA binding site [nucleotide binding]; other site 698967001657 salt bridge; other site 698967001658 sequence-specific DNA binding site [nucleotide binding]; other site 698967001659 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698967001660 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 698967001661 metal binding site [ion binding]; metal-binding site 698967001662 putative dimer interface [polypeptide binding]; other site 698967001663 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 698967001664 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698967001665 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698967001666 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698967001667 pyruvate carboxylase; Reviewed; Region: PRK12999 698967001668 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698967001669 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698967001670 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698967001671 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698967001672 active site 698967001673 catalytic residues [active] 698967001674 metal binding site [ion binding]; metal-binding site 698967001675 homodimer binding site [polypeptide binding]; other site 698967001676 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698967001677 carboxyltransferase (CT) interaction site; other site 698967001678 biotinylation site [posttranslational modification]; other site 698967001679 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 698967001680 ADP-ribose binding site [chemical binding]; other site 698967001681 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 698967001682 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698967001683 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 698967001684 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698967001685 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698967001686 carboxyltransferase (CT) interaction site; other site 698967001687 biotinylation site [posttranslational modification]; other site 698967001688 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698967001689 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698967001690 active site residue [active] 698967001691 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 698967001692 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698967001693 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 698967001694 active site 698967001695 dimer interface [polypeptide binding]; other site 698967001696 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 698967001697 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698967001698 substrate binding site [chemical binding]; other site 698967001699 dimer interface [polypeptide binding]; other site 698967001700 ATP binding site [chemical binding]; other site 698967001701 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698967001702 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698967001703 DNA binding site [nucleotide binding] 698967001704 domain linker motif; other site 698967001705 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 698967001706 dimerization interface [polypeptide binding]; other site 698967001707 putative ligand binding site [chemical binding]; other site 698967001708 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 698967001709 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698967001710 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698967001711 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698967001712 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698967001713 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698967001714 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698967001715 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 698967001716 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 698967001717 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 698967001718 ATP-grasp domain; Region: ATP-grasp; pfam02222 698967001719 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 698967001720 Uncharacterized conserved protein [Function unknown]; Region: COG1434 698967001721 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698967001722 putative active site [active] 698967001723 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 698967001724 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 698967001725 HupF/HypC family; Region: HupF_HypC; pfam01455 698967001726 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 698967001727 dimerization interface [polypeptide binding]; other site 698967001728 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 698967001729 ATP binding site [chemical binding]; other site 698967001730 Acylphosphatase; Region: Acylphosphatase; pfam00708 698967001731 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 698967001732 HypF finger; Region: zf-HYPF; pfam07503 698967001733 HypF finger; Region: zf-HYPF; pfam07503 698967001734 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 698967001735 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 698967001736 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698967001737 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 698967001738 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 698967001739 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 698967001740 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 698967001741 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 698967001742 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 698967001743 putative substrate-binding site; other site 698967001744 nickel binding site [ion binding]; other site 698967001745 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 698967001746 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 698967001747 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 698967001748 HupF/HypC family; Region: HupF_HypC; cl00394 698967001749 TIGR03089 family protein; Region: TIGR03089 698967001750 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698967001751 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698967001752 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698967001753 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698967001754 active site 698967001755 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698967001756 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 698967001757 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 698967001758 active site 698967001759 Substrate binding site; other site 698967001760 Mg++ binding site; other site 698967001761 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698967001762 putative trimer interface [polypeptide binding]; other site 698967001763 putative CoA binding site [chemical binding]; other site 698967001764 Transcription factor WhiB; Region: Whib; pfam02467 698967001765 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 698967001766 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 698967001767 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 698967001768 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 698967001769 active site 698967001770 substrate binding site [chemical binding]; other site 698967001771 metal binding site [ion binding]; metal-binding site 698967001772 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 698967001773 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698967001774 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698967001775 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 698967001776 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 698967001777 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 698967001778 homotetramer interface [polypeptide binding]; other site 698967001779 ligand binding site [chemical binding]; other site 698967001780 catalytic site [active] 698967001781 NAD binding site [chemical binding]; other site 698967001782 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 698967001783 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 698967001784 TMP-binding site; other site 698967001785 ATP-binding site [chemical binding]; other site 698967001786 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698967001787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698967001788 active site 698967001789 phosphorylation site [posttranslational modification] 698967001790 intermolecular recognition site; other site 698967001791 dimerization interface [polypeptide binding]; other site 698967001792 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698967001793 DNA binding site [nucleotide binding] 698967001794 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698967001795 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698967001796 dimerization interface [polypeptide binding]; other site 698967001797 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698967001798 dimer interface [polypeptide binding]; other site 698967001799 phosphorylation site [posttranslational modification] 698967001800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698967001801 ATP binding site [chemical binding]; other site 698967001802 Mg2+ binding site [ion binding]; other site 698967001803 G-X-G motif; other site 698967001804 lipoprotein LpqB; Provisional; Region: PRK13616 698967001805 Sporulation and spore germination; Region: Germane; pfam10646 698967001806 comF family protein; Region: comF; TIGR00201 698967001807 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698967001808 active site 698967001809 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 698967001810 30S subunit binding site; other site 698967001811 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 698967001812 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698967001813 ATP binding site [chemical binding]; other site 698967001814 putative Mg++ binding site [ion binding]; other site 698967001815 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 698967001816 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698967001817 nucleotide binding region [chemical binding]; other site 698967001818 ATP-binding site [chemical binding]; other site 698967001819 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 698967001820 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 698967001821 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698967001822 FAD binding pocket [chemical binding]; other site 698967001823 FAD binding motif [chemical binding]; other site 698967001824 phosphate binding motif [ion binding]; other site 698967001825 beta-alpha-beta structure motif; other site 698967001826 NAD binding pocket [chemical binding]; other site 698967001827 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698967001828 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 698967001829 catalytic loop [active] 698967001830 iron binding site [ion binding]; other site 698967001831 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 698967001832 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 698967001833 putative di-iron ligands [ion binding]; other site 698967001834 Predicted GTPases [General function prediction only]; Region: COG1162 698967001835 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 698967001836 GTPase/Zn-binding domain interface [polypeptide binding]; other site 698967001837 GTP/Mg2+ binding site [chemical binding]; other site 698967001838 G4 box; other site 698967001839 G5 box; other site 698967001840 G1 box; other site 698967001841 Switch I region; other site 698967001842 G2 box; other site 698967001843 G3 box; other site 698967001844 Switch II region; other site 698967001845 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 698967001846 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 698967001847 hinge; other site 698967001848 active site 698967001849 Uncharacterized conserved protein [Function unknown]; Region: COG2135 698967001850 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 698967001851 putative deacylase active site [active] 698967001852 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 698967001853 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698967001854 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698967001855 DNA binding residues [nucleotide binding] 698967001856 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 698967001857 Transcription factor WhiB; Region: Whib; pfam02467 698967001858 PQQ-like domain; Region: PQQ_2; pfam13360 698967001859 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698967001860 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698967001861 ATP binding site [chemical binding]; other site 698967001862 putative Mg++ binding site [ion binding]; other site 698967001863 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698967001864 nucleotide binding region [chemical binding]; other site 698967001865 ATP-binding site [chemical binding]; other site 698967001866 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 698967001867 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 698967001868 TIGR02569 family protein; Region: TIGR02569_actnb 698967001869 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698967001870 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698967001871 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698967001872 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698967001873 Part of AAA domain; Region: AAA_19; pfam13245 698967001874 Family description; Region: UvrD_C_2; pfam13538 698967001875 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698967001876 Ion channel; Region: Ion_trans_2; pfam07885 698967001877 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 698967001878 TrkA-N domain; Region: TrkA_N; pfam02254 698967001879 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 698967001880 putative NADH binding site [chemical binding]; other site 698967001881 putative active site [active] 698967001882 nudix motif; other site 698967001883 putative metal binding site [ion binding]; other site 698967001884 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 698967001885 Part of AAA domain; Region: AAA_19; pfam13245 698967001886 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698967001887 Family description; Region: UvrD_C_2; pfam13538 698967001888 HRDC domain; Region: HRDC; pfam00570 698967001889 Protein of unknown function DUF45; Region: DUF45; pfam01863 698967001890 putative hydrolase; Region: TIGR03624 698967001891 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 698967001892 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698967001893 hypothetical protein; Validated; Region: PRK00068 698967001894 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 698967001895 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698967001896 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 698967001897 active site 698967001898 Protein of unknown function (DUF418); Region: DUF418; cl12135 698967001899 oxaloacetate decarboxylase; Provisional; Region: PRK12330 698967001900 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698967001901 active site 698967001902 catalytic residues [active] 698967001903 metal binding site [ion binding]; metal-binding site 698967001904 homodimer binding site [polypeptide binding]; other site 698967001905 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 698967001906 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698967001907 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698967001908 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698967001909 carboxyltransferase (CT) interaction site; other site 698967001910 biotinylation site [posttranslational modification]; other site 698967001911 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698967001912 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 698967001913 active site 698967001914 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698967001915 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698967001916 active site 698967001917 peptide chain release factor 2; Validated; Region: prfB; PRK00578 698967001918 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698967001919 RF-1 domain; Region: RF-1; pfam00472 698967001920 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 698967001921 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 698967001922 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698967001923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967001924 Walker A/P-loop; other site 698967001925 ATP binding site [chemical binding]; other site 698967001926 Q-loop/lid; other site 698967001927 ABC transporter signature motif; other site 698967001928 Walker B; other site 698967001929 D-loop; other site 698967001930 H-loop/switch region; other site 698967001931 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 698967001932 FtsX-like permease family; Region: FtsX; pfam02687 698967001933 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 698967001934 SmpB-tmRNA interface; other site 698967001935 Cupin domain; Region: Cupin_2; cl17218 698967001936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698967001937 S-adenosylmethionine binding site [chemical binding]; other site 698967001938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698967001939 Helix-turn-helix domain; Region: HTH_28; pfam13518 698967001940 putative transposase OrfB; Reviewed; Region: PHA02517 698967001941 HTH-like domain; Region: HTH_21; pfam13276 698967001942 Integrase core domain; Region: rve; pfam00665 698967001943 Integrase core domain; Region: rve_2; pfam13333 698967001944 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698967001945 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698967001946 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698967001947 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698967001948 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698967001949 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698967001950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698967001951 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 698967001952 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698967001953 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698967001954 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698967001955 nucleotide binding region [chemical binding]; other site 698967001956 ATP-binding site [chemical binding]; other site 698967001957 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698967001958 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698967001959 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 698967001960 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698967001961 DNA-binding site [nucleotide binding]; DNA binding site 698967001962 RNA-binding motif; other site 698967001963 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 698967001964 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 698967001965 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 698967001966 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 698967001967 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698967001968 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698967001969 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 698967001970 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698967001971 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698967001972 catalytic residue [active] 698967001973 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 698967001974 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 698967001975 dimer interface [polypeptide binding]; other site 698967001976 active site 698967001977 citrylCoA binding site [chemical binding]; other site 698967001978 NADH binding [chemical binding]; other site 698967001979 cationic pore residues; other site 698967001980 oxalacetate/citrate binding site [chemical binding]; other site 698967001981 coenzyme A binding site [chemical binding]; other site 698967001982 catalytic triad [active] 698967001983 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698967001984 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 698967001985 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698967001986 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698967001987 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698967001988 active site 698967001989 catalytic tetrad [active] 698967001990 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 698967001991 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698967001992 substrate binding site [chemical binding]; other site 698967001993 oxyanion hole (OAH) forming residues; other site 698967001994 trimer interface [polypeptide binding]; other site 698967001995 Protein of unknown function, DUF485; Region: DUF485; pfam04341 698967001996 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698967001997 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 698967001998 Na binding site [ion binding]; other site 698967001999 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 698967002000 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 698967002001 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698967002002 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 698967002003 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 698967002004 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698967002005 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 698967002006 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 698967002007 DNA methylase; Region: N6_N4_Mtase; pfam01555 698967002008 DNA methylase; Region: N6_N4_Mtase; pfam01555 698967002009 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698967002010 active site 698967002011 Int/Topo IB signature motif; other site 698967002012 catalytic residues [active] 698967002013 DNA binding site [nucleotide binding] 698967002014 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 698967002015 active site 698967002016 SAM binding site [chemical binding]; other site 698967002017 homodimer interface [polypeptide binding]; other site 698967002018 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698967002019 catalytic residues [active] 698967002020 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 698967002021 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 698967002022 folate binding site [chemical binding]; other site 698967002023 NADP+ binding site [chemical binding]; other site 698967002024 thymidylate synthase; Reviewed; Region: thyA; PRK01827 698967002025 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 698967002026 dimerization interface [polypeptide binding]; other site 698967002027 active site 698967002028 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 698967002029 active site 698967002030 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698967002031 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 698967002032 ATP binding site [chemical binding]; other site 698967002033 putative Mg++ binding site [ion binding]; other site 698967002034 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698967002035 nucleotide binding region [chemical binding]; other site 698967002036 ATP-binding site [chemical binding]; other site 698967002037 DEAD/H associated; Region: DEAD_assoc; pfam08494 698967002038 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 698967002039 active site 698967002040 SUMO-1 interface [polypeptide binding]; other site 698967002041 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698967002042 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 698967002043 putative DNA binding site [nucleotide binding]; other site 698967002044 catalytic residue [active] 698967002045 putative H2TH interface [polypeptide binding]; other site 698967002046 putative catalytic residues [active] 698967002047 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698967002048 Predicted permease [General function prediction only]; Region: COG2985 698967002049 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698967002050 TrkA-C domain; Region: TrkA_C; pfam02080 698967002051 TrkA-C domain; Region: TrkA_C; pfam02080 698967002052 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698967002053 hypothetical protein; Provisional; Region: PRK11770 698967002054 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698967002055 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698967002056 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 698967002057 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 698967002058 active site 698967002059 dimer interface [polypeptide binding]; other site 698967002060 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 698967002061 dimer interface [polypeptide binding]; other site 698967002062 active site 698967002063 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698967002064 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698967002065 tetramerization interface [polypeptide binding]; other site 698967002066 NAD(P) binding site [chemical binding]; other site 698967002067 catalytic residues [active] 698967002068 hypothetical protein; Provisional; Region: PRK07857 698967002069 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 698967002070 Part of AAA domain; Region: AAA_19; pfam13245 698967002071 Family description; Region: UvrD_C_2; pfam13538 698967002072 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698967002073 Peptidase family M23; Region: Peptidase_M23; pfam01551 698967002074 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 698967002075 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 698967002076 active site 698967002077 substrate binding site [chemical binding]; other site 698967002078 cosubstrate binding site; other site 698967002079 catalytic site [active] 698967002080 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 698967002081 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 698967002082 purine monophosphate binding site [chemical binding]; other site 698967002083 dimer interface [polypeptide binding]; other site 698967002084 putative catalytic residues [active] 698967002085 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 698967002086 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698967002087 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 698967002088 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698967002089 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698967002090 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 698967002091 30S ribosomal protein S18; Provisional; Region: PRK13401 698967002092 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 698967002093 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 698967002094 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 698967002095 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 698967002096 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 698967002097 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698967002098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698967002099 active site 698967002100 phosphorylation site [posttranslational modification] 698967002101 intermolecular recognition site; other site 698967002102 dimerization interface [polypeptide binding]; other site 698967002103 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698967002104 DNA binding site [nucleotide binding] 698967002105 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698967002106 dimerization interface [polypeptide binding]; other site 698967002107 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698967002108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698967002109 dimer interface [polypeptide binding]; other site 698967002110 phosphorylation site [posttranslational modification] 698967002111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698967002112 ATP binding site [chemical binding]; other site 698967002113 Mg2+ binding site [ion binding]; other site 698967002114 G-X-G motif; other site 698967002115 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698967002116 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698967002117 protein binding site [polypeptide binding]; other site 698967002118 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698967002119 MPT binding site; other site 698967002120 trimer interface [polypeptide binding]; other site 698967002121 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 698967002122 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 698967002123 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 698967002124 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 698967002125 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 698967002126 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 698967002127 active site 698967002128 tetramer interface; other site 698967002129 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698967002130 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698967002131 dimer interface [polypeptide binding]; other site 698967002132 putative functional site; other site 698967002133 putative MPT binding site; other site 698967002134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698967002135 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698967002136 Predicted membrane protein [Function unknown]; Region: COG2259 698967002137 Predicted integral membrane protein [Function unknown]; Region: COG5660 698967002138 Putative zinc-finger; Region: zf-HC2; pfam13490 698967002139 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 698967002140 BCCT family transporter; Region: BCCT; pfam02028 698967002141 Uncharacterized membrane protein [Function unknown]; Region: COG3949 698967002142 Predicted methyltransferases [General function prediction only]; Region: COG0313 698967002143 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 698967002144 putative SAM binding site [chemical binding]; other site 698967002145 putative homodimer interface [polypeptide binding]; other site 698967002146 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 698967002147 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 698967002148 active site 698967002149 HIGH motif; other site 698967002150 KMSKS motif; other site 698967002151 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 698967002152 tRNA binding surface [nucleotide binding]; other site 698967002153 anticodon binding site; other site 698967002154 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 698967002155 active site 698967002156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 698967002157 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698967002158 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698967002159 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698967002160 G5 domain; Region: G5; pfam07501 698967002161 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698967002162 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 698967002163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698967002164 S-adenosylmethionine binding site [chemical binding]; other site 698967002165 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 698967002166 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698967002167 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698967002168 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698967002169 ABC transporter; Region: ABC_tran_2; pfam12848 698967002170 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698967002171 Uncharacterized conserved protein [Function unknown]; Region: COG1359 698967002172 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698967002173 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698967002174 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698967002175 DNA binding residues [nucleotide binding] 698967002176 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698967002177 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 698967002178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698967002179 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698967002180 active site 698967002181 motif I; other site 698967002182 motif II; other site 698967002183 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698967002184 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 698967002185 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698967002186 substrate binding site [chemical binding]; other site 698967002187 oxyanion hole (OAH) forming residues; other site 698967002188 trimer interface [polypeptide binding]; other site 698967002189 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 698967002190 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698967002191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698967002192 potential frameshift: common BLAST hit: gi|38233488|ref|NP_939255.1| glyceraldehyde-3-phosphate dehydrogenase 698967002193 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698967002194 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 698967002195 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698967002196 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 698967002197 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 698967002198 G1 box; other site 698967002199 putative GEF interaction site [polypeptide binding]; other site 698967002200 GTP/Mg2+ binding site [chemical binding]; other site 698967002201 Switch I region; other site 698967002202 G2 box; other site 698967002203 G3 box; other site 698967002204 Switch II region; other site 698967002205 G4 box; other site 698967002206 G5 box; other site 698967002207 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 698967002208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698967002209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698967002210 NAD(P) binding site [chemical binding]; other site 698967002211 active site 698967002212 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698967002213 putative active site [active] 698967002214 catalytic residue [active] 698967002215 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698967002216 active site 698967002217 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698967002218 putative active site [active] 698967002219 catalytic residue [active] 698967002220 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 698967002221 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 698967002222 5S rRNA interface [nucleotide binding]; other site 698967002223 CTC domain interface [polypeptide binding]; other site 698967002224 L16 interface [polypeptide binding]; other site 698967002225 pullulanase, type I; Region: pulA_typeI; TIGR02104 698967002226 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 698967002227 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 698967002228 Ca binding site [ion binding]; other site 698967002229 active site 698967002230 catalytic site [active] 698967002231 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 698967002232 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 698967002233 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698967002234 active site 698967002235 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 698967002236 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 698967002237 Substrate binding site; other site 698967002238 Mg++ binding site; other site 698967002239 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 698967002240 active site 698967002241 substrate binding site [chemical binding]; other site 698967002242 CoA binding site [chemical binding]; other site 698967002243 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698967002244 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698967002245 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 698967002246 putative dimerization interface [polypeptide binding]; other site 698967002247 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 698967002248 gating phenylalanine in ion channel; other site 698967002249 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698967002250 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 698967002251 putative ligand binding site [chemical binding]; other site 698967002252 putative NAD binding site [chemical binding]; other site 698967002253 catalytic site [active] 698967002254 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698967002255 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698967002256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967002257 Q-loop/lid; other site 698967002258 ABC transporter signature motif; other site 698967002259 Walker B; other site 698967002260 D-loop; other site 698967002261 H-loop/switch region; other site 698967002262 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698967002263 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698967002264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967002265 Walker A/P-loop; other site 698967002266 ATP binding site [chemical binding]; other site 698967002267 Q-loop/lid; other site 698967002268 ABC transporter signature motif; other site 698967002269 Walker B; other site 698967002270 D-loop; other site 698967002271 H-loop/switch region; other site 698967002272 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698967002273 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698967002274 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 698967002275 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 698967002276 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698967002277 ATP binding site [chemical binding]; other site 698967002278 putative Mg++ binding site [ion binding]; other site 698967002279 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698967002280 nucleotide binding region [chemical binding]; other site 698967002281 ATP-binding site [chemical binding]; other site 698967002282 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 698967002283 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 698967002284 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 698967002285 homodimer interface [polypeptide binding]; other site 698967002286 metal binding site [ion binding]; metal-binding site 698967002287 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 698967002288 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698967002289 enolase; Provisional; Region: eno; PRK00077 698967002290 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 698967002291 dimer interface [polypeptide binding]; other site 698967002292 metal binding site [ion binding]; metal-binding site 698967002293 substrate binding pocket [chemical binding]; other site 698967002294 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 698967002295 Septum formation initiator; Region: DivIC; pfam04977 698967002296 Uncharacterized conserved protein [Function unknown]; Region: COG1507 698967002297 exopolyphosphatase; Region: exo_poly_only; TIGR03706 698967002298 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698967002299 Helix-turn-helix domain; Region: HTH_18; pfam12833 698967002300 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698967002301 Bax inhibitor 1 like; Region: BaxI_1; cl17691 698967002302 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 698967002303 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 698967002304 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 698967002305 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 698967002306 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 698967002307 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 698967002308 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698967002309 catalytic residue [active] 698967002310 putative FPP diphosphate binding site; other site 698967002311 putative FPP binding hydrophobic cleft; other site 698967002312 dimer interface [polypeptide binding]; other site 698967002313 putative IPP diphosphate binding site; other site 698967002314 Flavodoxin domain; Region: Flavodoxin_5; cl17428 698967002315 pantothenate kinase; Provisional; Region: PRK05439 698967002316 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 698967002317 ATP-binding site [chemical binding]; other site 698967002318 CoA-binding site [chemical binding]; other site 698967002319 Mg2+-binding site [ion binding]; other site 698967002320 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 698967002321 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 698967002322 dimer interface [polypeptide binding]; other site 698967002323 active site 698967002324 glycine-pyridoxal phosphate binding site [chemical binding]; other site 698967002325 folate binding site [chemical binding]; other site 698967002326 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698967002327 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 698967002328 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698967002329 Coenzyme A binding pocket [chemical binding]; other site 698967002330 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698967002331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967002332 putative substrate translocation pore; other site 698967002333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967002334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698967002335 fumarate hydratase; Reviewed; Region: fumC; PRK00485 698967002336 Class II fumarases; Region: Fumarase_classII; cd01362 698967002337 active site 698967002338 tetramer interface [polypeptide binding]; other site 698967002339 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 698967002340 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 698967002341 putative active site [active] 698967002342 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 698967002343 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 698967002344 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 698967002345 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 698967002346 generic binding surface II; other site 698967002347 generic binding surface I; other site 698967002348 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 698967002349 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 698967002350 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698967002351 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698967002352 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 698967002353 Na2 binding site [ion binding]; other site 698967002354 putative substrate binding site 1 [chemical binding]; other site 698967002355 Na binding site 1 [ion binding]; other site 698967002356 putative substrate binding site 2 [chemical binding]; other site 698967002357 GTP-binding protein YchF; Reviewed; Region: PRK09601 698967002358 YchF GTPase; Region: YchF; cd01900 698967002359 G1 box; other site 698967002360 GTP/Mg2+ binding site [chemical binding]; other site 698967002361 Switch I region; other site 698967002362 G2 box; other site 698967002363 Switch II region; other site 698967002364 G3 box; other site 698967002365 G4 box; other site 698967002366 G5 box; other site 698967002367 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 698967002368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 698967002369 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 698967002370 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 698967002371 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 698967002372 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 698967002373 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 698967002374 Cl- selectivity filter; other site 698967002375 Cl- binding residues [ion binding]; other site 698967002376 pore gating glutamate residue; other site 698967002377 dimer interface [polypeptide binding]; other site 698967002378 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698967002379 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698967002380 Walker A/P-loop; other site 698967002381 ATP binding site [chemical binding]; other site 698967002382 Q-loop/lid; other site 698967002383 ABC transporter signature motif; other site 698967002384 Walker B; other site 698967002385 D-loop; other site 698967002386 H-loop/switch region; other site 698967002387 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 698967002388 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698967002389 Walker A/P-loop; other site 698967002390 ATP binding site [chemical binding]; other site 698967002391 Q-loop/lid; other site 698967002392 ABC transporter signature motif; other site 698967002393 Walker B; other site 698967002394 D-loop; other site 698967002395 H-loop/switch region; other site 698967002396 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698967002397 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 698967002398 active site 698967002399 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698967002400 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698967002401 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698967002402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698967002403 dimer interface [polypeptide binding]; other site 698967002404 conserved gate region; other site 698967002405 ABC-ATPase subunit interface; other site 698967002406 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698967002407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698967002408 dimer interface [polypeptide binding]; other site 698967002409 conserved gate region; other site 698967002410 putative PBP binding loops; other site 698967002411 ABC-ATPase subunit interface; other site 698967002412 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698967002413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967002414 Walker A/P-loop; other site 698967002415 ATP binding site [chemical binding]; other site 698967002416 ABC transporter signature motif; other site 698967002417 Walker B; other site 698967002418 D-loop; other site 698967002419 H-loop/switch region; other site 698967002420 Integrase core domain; Region: rve; pfam00665 698967002421 Trypsin; Region: Trypsin; pfam00089 698967002422 active site 698967002423 substrate binding sites [chemical binding]; other site 698967002424 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 698967002425 ArsC family; Region: ArsC; pfam03960 698967002426 catalytic residues [active] 698967002427 Protein of unknown function (DUF402); Region: DUF402; cl00979 698967002428 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 698967002429 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 698967002430 G1 box; other site 698967002431 GTP/Mg2+ binding site [chemical binding]; other site 698967002432 G2 box; other site 698967002433 Switch I region; other site 698967002434 G3 box; other site 698967002435 Switch II region; other site 698967002436 G4 box; other site 698967002437 G5 box; other site 698967002438 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 698967002439 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 698967002440 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 698967002441 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698967002442 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 698967002443 Ferredoxin [Energy production and conversion]; Region: COG1146 698967002444 4Fe-4S binding domain; Region: Fer4; pfam00037 698967002445 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 698967002446 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698967002447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698967002448 homodimer interface [polypeptide binding]; other site 698967002449 catalytic residue [active] 698967002450 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698967002451 active site 698967002452 Predicted membrane protein [Function unknown]; Region: COG2246 698967002453 GtrA-like protein; Region: GtrA; pfam04138 698967002454 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698967002455 active site 698967002456 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 698967002457 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698967002458 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 698967002459 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 698967002460 putative trimer interface [polypeptide binding]; other site 698967002461 putative CoA binding site [chemical binding]; other site 698967002462 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 698967002463 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698967002464 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 698967002465 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698967002466 putative trimer interface [polypeptide binding]; other site 698967002467 putative CoA binding site [chemical binding]; other site 698967002468 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 698967002469 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 698967002470 metal binding site [ion binding]; metal-binding site 698967002471 putative dimer interface [polypeptide binding]; other site 698967002472 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698967002473 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698967002474 dihydropteroate synthase; Region: DHPS; TIGR01496 698967002475 substrate binding pocket [chemical binding]; other site 698967002476 dimer interface [polypeptide binding]; other site 698967002477 inhibitor binding site; inhibition site 698967002478 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 698967002479 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 698967002480 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 698967002481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698967002482 S-adenosylmethionine binding site [chemical binding]; other site 698967002483 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 698967002484 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 698967002485 active site 698967002486 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 698967002487 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 698967002488 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 698967002489 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698967002490 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 698967002491 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 698967002492 ligand binding site; other site 698967002493 oligomer interface; other site 698967002494 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 698967002495 dimer interface [polypeptide binding]; other site 698967002496 N-terminal domain interface [polypeptide binding]; other site 698967002497 sulfate 1 binding site; other site 698967002498 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 698967002499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698967002500 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 698967002501 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698967002502 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698967002503 DNA binding residues [nucleotide binding] 698967002504 Putative zinc-finger; Region: zf-HC2; pfam13490 698967002505 sec-independent translocase; Provisional; Region: tatB; PRK00182 698967002506 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 698967002507 Domain of unknown function DUF59; Region: DUF59; pfam01883 698967002508 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 698967002509 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 698967002510 Predicted membrane protein [Function unknown]; Region: COG4420 698967002511 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 698967002512 MgtE intracellular N domain; Region: MgtE_N; smart00924 698967002513 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 698967002514 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 698967002515 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 698967002516 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698967002517 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 698967002518 TPP-binding site [chemical binding]; other site 698967002519 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 698967002520 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698967002521 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698967002522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967002523 Walker A/P-loop; other site 698967002524 ATP binding site [chemical binding]; other site 698967002525 Q-loop/lid; other site 698967002526 ABC transporter signature motif; other site 698967002527 Walker B; other site 698967002528 D-loop; other site 698967002529 H-loop/switch region; other site 698967002530 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698967002531 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698967002532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967002533 Walker A/P-loop; other site 698967002534 ATP binding site [chemical binding]; other site 698967002535 Q-loop/lid; other site 698967002536 ABC transporter signature motif; other site 698967002537 Walker B; other site 698967002538 D-loop; other site 698967002539 H-loop/switch region; other site 698967002540 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 698967002541 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698967002542 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698967002543 shikimate binding site; other site 698967002544 NAD(P) binding site [chemical binding]; other site 698967002545 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698967002546 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698967002547 substrate binding pocket [chemical binding]; other site 698967002548 catalytic triad [active] 698967002549 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 698967002550 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 698967002551 active site 698967002552 catalytic residues [active] 698967002553 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698967002554 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 698967002555 Na binding site [ion binding]; other site 698967002556 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698967002557 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 698967002558 nucleotide binding site/active site [active] 698967002559 HIT family signature motif; other site 698967002560 catalytic residue [active] 698967002561 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 698967002562 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698967002563 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698967002564 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698967002565 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 698967002566 PLD-like domain; Region: PLDc_2; pfam13091 698967002567 putative homodimer interface [polypeptide binding]; other site 698967002568 putative active site [active] 698967002569 catalytic site [active] 698967002570 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698967002571 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698967002572 putative Mg++ binding site [ion binding]; other site 698967002573 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698967002574 nucleotide binding region [chemical binding]; other site 698967002575 ATP-binding site [chemical binding]; other site 698967002576 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 698967002577 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 698967002578 active site 698967002579 8-oxo-dGMP binding site [chemical binding]; other site 698967002580 nudix motif; other site 698967002581 metal binding site [ion binding]; metal-binding site 698967002582 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 698967002583 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698967002584 ATP binding site [chemical binding]; other site 698967002585 Mg++ binding site [ion binding]; other site 698967002586 motif III; other site 698967002587 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698967002588 nucleotide binding region [chemical binding]; other site 698967002589 ATP-binding site [chemical binding]; other site 698967002590 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 698967002591 putative RNA binding site [nucleotide binding]; other site 698967002592 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698967002593 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698967002594 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 698967002595 Na binding site [ion binding]; other site 698967002596 SNF2 Helicase protein; Region: DUF3670; pfam12419 698967002597 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 698967002598 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698967002599 ATP binding site [chemical binding]; other site 698967002600 putative Mg++ binding site [ion binding]; other site 698967002601 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698967002602 nucleotide binding region [chemical binding]; other site 698967002603 ATP-binding site [chemical binding]; other site 698967002604 Uncharacterized conserved protein [Function unknown]; Region: COG4279 698967002605 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 698967002606 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 698967002607 active site 698967002608 metal binding site [ion binding]; metal-binding site 698967002609 DNA binding site [nucleotide binding] 698967002610 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 698967002611 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967002612 Walker A/P-loop; other site 698967002613 ATP binding site [chemical binding]; other site 698967002614 Q-loop/lid; other site 698967002615 Uncharacterized conserved protein [Function unknown]; Region: COG2353 698967002616 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698967002617 MarR family; Region: MarR_2; pfam12802 698967002618 PspC domain; Region: PspC; cl00864 698967002619 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698967002620 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 698967002621 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698967002622 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 698967002623 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698967002624 Cysteine-rich domain; Region: CCG; pfam02754 698967002625 Cysteine-rich domain; Region: CCG; pfam02754 698967002626 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698967002627 L-lactate permease; Region: Lactate_perm; cl00701 698967002628 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 698967002629 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 698967002630 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 698967002631 active site 698967002632 HIGH motif; other site 698967002633 KMSK motif region; other site 698967002634 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 698967002635 tRNA binding surface [nucleotide binding]; other site 698967002636 anticodon binding site; other site 698967002637 diaminopimelate decarboxylase; Region: lysA; TIGR01048 698967002638 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 698967002639 active site 698967002640 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698967002641 substrate binding site [chemical binding]; other site 698967002642 catalytic residues [active] 698967002643 dimer interface [polypeptide binding]; other site 698967002644 homoserine dehydrogenase; Provisional; Region: PRK06349 698967002645 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 698967002646 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 698967002647 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 698967002648 homoserine kinase; Provisional; Region: PRK01212 698967002649 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 698967002650 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698967002651 acyl-activating enzyme (AAE) consensus motif; other site 698967002652 AMP binding site [chemical binding]; other site 698967002653 active site 698967002654 CoA binding site [chemical binding]; other site 698967002655 transcription termination factor Rho; Provisional; Region: PRK12678 698967002656 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 698967002657 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698967002658 RNA binding site [nucleotide binding]; other site 698967002659 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 698967002660 multimer interface [polypeptide binding]; other site 698967002661 Walker A motif; other site 698967002662 ATP binding site [chemical binding]; other site 698967002663 Walker B motif; other site 698967002664 peptide chain release factor 1; Validated; Region: prfA; PRK00591 698967002665 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698967002666 RF-1 domain; Region: RF-1; pfam00472 698967002667 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 698967002668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698967002669 S-adenosylmethionine binding site [chemical binding]; other site 698967002670 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 698967002671 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 698967002672 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 698967002673 Mg++ binding site [ion binding]; other site 698967002674 putative catalytic motif [active] 698967002675 substrate binding site [chemical binding]; other site 698967002676 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 698967002677 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 698967002678 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 698967002679 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 698967002680 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 698967002681 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 698967002682 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 698967002683 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 698967002684 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698967002685 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 698967002686 beta subunit interaction interface [polypeptide binding]; other site 698967002687 Walker A motif; other site 698967002688 ATP binding site [chemical binding]; other site 698967002689 Walker B motif; other site 698967002690 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698967002691 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 698967002692 core domain interface [polypeptide binding]; other site 698967002693 delta subunit interface [polypeptide binding]; other site 698967002694 epsilon subunit interface [polypeptide binding]; other site 698967002695 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 698967002696 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698967002697 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 698967002698 alpha subunit interaction interface [polypeptide binding]; other site 698967002699 Walker A motif; other site 698967002700 ATP binding site [chemical binding]; other site 698967002701 Walker B motif; other site 698967002702 inhibitor binding site; inhibition site 698967002703 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698967002704 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 698967002705 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 698967002706 gamma subunit interface [polypeptide binding]; other site 698967002707 epsilon subunit interface [polypeptide binding]; other site 698967002708 LBP interface [polypeptide binding]; other site 698967002709 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 698967002710 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 698967002711 hypothetical protein; Provisional; Region: PRK03298 698967002712 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 698967002713 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698967002714 dimer interface [polypeptide binding]; other site 698967002715 substrate binding site [chemical binding]; other site 698967002716 metal binding site [ion binding]; metal-binding site 698967002717 Domain of unknown function DUF77; Region: DUF77; pfam01910 698967002718 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698967002719 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698967002720 Walker A/P-loop; other site 698967002721 ATP binding site [chemical binding]; other site 698967002722 Q-loop/lid; other site 698967002723 ABC transporter signature motif; other site 698967002724 Walker B; other site 698967002725 D-loop; other site 698967002726 H-loop/switch region; other site 698967002727 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698967002728 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698967002729 ABC-ATPase subunit interface; other site 698967002730 dimer interface [polypeptide binding]; other site 698967002731 putative PBP binding regions; other site 698967002732 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698967002733 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698967002734 ABC-ATPase subunit interface; other site 698967002735 dimer interface [polypeptide binding]; other site 698967002736 putative PBP binding regions; other site 698967002737 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 698967002738 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698967002739 siderophore binding site; other site 698967002740 TIGR02611 family protein; Region: TIGR02611 698967002741 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 698967002742 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 698967002743 glycogen branching enzyme; Provisional; Region: PRK05402 698967002744 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 698967002745 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 698967002746 active site 698967002747 catalytic site [active] 698967002748 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 698967002749 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 698967002750 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 698967002751 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698967002752 active site 698967002753 homodimer interface [polypeptide binding]; other site 698967002754 catalytic site [active] 698967002755 acceptor binding site [chemical binding]; other site 698967002756 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698967002757 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967002758 Walker A/P-loop; other site 698967002759 ATP binding site [chemical binding]; other site 698967002760 Q-loop/lid; other site 698967002761 ABC transporter signature motif; other site 698967002762 Walker B; other site 698967002763 D-loop; other site 698967002764 H-loop/switch region; other site 698967002765 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 698967002766 Ligand binding site [chemical binding]; other site 698967002767 Electron transfer flavoprotein domain; Region: ETF; pfam01012 698967002768 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 698967002769 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 698967002770 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 698967002771 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 698967002772 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 698967002773 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698967002774 catalytic residue [active] 698967002775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698967002776 S-adenosylmethionine binding site [chemical binding]; other site 698967002777 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 698967002778 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 698967002779 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698967002780 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698967002781 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698967002782 active site 698967002783 catalytic site [active] 698967002784 substrate binding site [chemical binding]; other site 698967002785 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 698967002786 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 698967002787 nucleotide binding pocket [chemical binding]; other site 698967002788 K-X-D-G motif; other site 698967002789 catalytic site [active] 698967002790 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 698967002791 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 698967002792 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 698967002793 Dimer interface [polypeptide binding]; other site 698967002794 BRCT sequence motif; other site 698967002795 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698967002796 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 698967002797 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698967002798 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 698967002799 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 698967002800 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698967002801 Coenzyme A binding pocket [chemical binding]; other site 698967002802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967002803 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698967002804 putative substrate translocation pore; other site 698967002805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967002806 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698967002807 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698967002808 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698967002809 ABC-ATPase subunit interface; other site 698967002810 dimer interface [polypeptide binding]; other site 698967002811 putative PBP binding regions; other site 698967002812 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698967002813 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967002814 Walker A/P-loop; other site 698967002815 ATP binding site [chemical binding]; other site 698967002816 Q-loop/lid; other site 698967002817 ABC transporter signature motif; other site 698967002818 Walker B; other site 698967002819 D-loop; other site 698967002820 H-loop/switch region; other site 698967002821 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 698967002822 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 698967002823 putative ligand binding residues [chemical binding]; other site 698967002824 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 698967002825 phosphofructokinase; Region: PFK_mixed; TIGR02483 698967002826 active site 698967002827 ADP/pyrophosphate binding site [chemical binding]; other site 698967002828 dimerization interface [polypeptide binding]; other site 698967002829 allosteric effector site; other site 698967002830 fructose-1,6-bisphosphate binding site; other site 698967002831 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 698967002832 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 698967002833 GatB domain; Region: GatB_Yqey; smart00845 698967002834 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698967002835 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698967002836 active site 698967002837 catalytic tetrad [active] 698967002838 Lysine efflux permease [General function prediction only]; Region: COG1279 698967002839 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 698967002840 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698967002841 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698967002842 dimerization interface [polypeptide binding]; other site 698967002843 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 698967002844 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 698967002845 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 698967002846 putative dimer interface [polypeptide binding]; other site 698967002847 N-terminal domain interface [polypeptide binding]; other site 698967002848 putative substrate binding pocket (H-site) [chemical binding]; other site 698967002849 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698967002850 Predicted membrane protein [Function unknown]; Region: COG2259 698967002851 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 698967002852 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698967002853 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 698967002854 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698967002855 PYR/PP interface [polypeptide binding]; other site 698967002856 dimer interface [polypeptide binding]; other site 698967002857 TPP binding site [chemical binding]; other site 698967002858 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698967002859 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 698967002860 TPP-binding site [chemical binding]; other site 698967002861 dimer interface [polypeptide binding]; other site 698967002862 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 698967002863 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 698967002864 putative valine binding site [chemical binding]; other site 698967002865 dimer interface [polypeptide binding]; other site 698967002866 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 698967002867 ketol-acid reductoisomerase; Provisional; Region: PRK05479 698967002868 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 698967002869 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 698967002870 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 698967002871 Uncharacterized conserved protein [Function unknown]; Region: COG1479 698967002872 Protein of unknown function DUF262; Region: DUF262; pfam03235 698967002873 Uncharacterized conserved protein [Function unknown]; Region: COG3472 698967002874 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 698967002875 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 698967002876 ligand binding site [chemical binding]; other site 698967002877 NAD binding site [chemical binding]; other site 698967002878 dimerization interface [polypeptide binding]; other site 698967002879 catalytic site [active] 698967002880 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 698967002881 putative L-serine binding site [chemical binding]; other site 698967002882 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 698967002883 tartrate dehydrogenase; Region: TTC; TIGR02089 698967002884 potential frameshift: common BLAST hit: gi|62390174|ref|YP_225576.1| signal transduction protein 698967002885 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698967002886 ligand binding site [chemical binding]; other site 698967002887 flexible hinge region; other site 698967002888 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698967002889 potential frameshift: common BLAST hit: gi|62390174|ref|YP_225576.1| signal transduction protein 698967002890 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698967002891 metal binding triad; other site 698967002892 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 698967002893 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698967002894 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698967002895 catalytic site [active] 698967002896 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 698967002897 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 698967002898 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 698967002899 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698967002900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698967002901 S-adenosylmethionine binding site [chemical binding]; other site 698967002902 isochorismate synthase DhbC; Validated; Region: PRK06923 698967002903 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698967002904 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 698967002905 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698967002906 active site 698967002907 HIGH motif; other site 698967002908 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698967002909 active site 698967002910 KMSKS motif; other site 698967002911 Predicted esterase [General function prediction only]; Region: COG0400 698967002912 MMPL family; Region: MMPL; pfam03176 698967002913 Ethanolamine utilisation protein, EutH; Region: EutH; cl01248 698967002914 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698967002915 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698967002916 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698967002917 Cutinase; Region: Cutinase; pfam01083 698967002918 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 698967002919 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 698967002920 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 698967002921 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 698967002922 PhnA protein; Region: PhnA; pfam03831 698967002923 biotin synthase; Region: bioB; TIGR00433 698967002924 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698967002925 FeS/SAM binding site; other site 698967002926 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698967002927 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698967002928 HD domain; Region: HD_4; pfam13328 698967002929 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698967002930 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698967002931 putative DNA binding site [nucleotide binding]; other site 698967002932 putative Zn2+ binding site [ion binding]; other site 698967002933 Bacterial transcriptional regulator; Region: IclR; pfam01614 698967002934 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 698967002935 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 698967002936 substrate binding site [chemical binding]; other site 698967002937 ligand binding site [chemical binding]; other site 698967002938 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 698967002939 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 698967002940 substrate binding site [chemical binding]; other site 698967002941 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698967002942 active site 698967002943 Ap6A binding site [chemical binding]; other site 698967002944 nudix motif; other site 698967002945 metal binding site [ion binding]; metal-binding site 698967002946 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698967002947 catalytic core [active] 698967002948 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 698967002949 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698967002950 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 698967002951 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 698967002952 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 698967002953 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698967002954 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698967002955 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698967002956 thiamine monophosphate kinase; Provisional; Region: PRK05731 698967002957 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 698967002958 ATP binding site [chemical binding]; other site 698967002959 dimerization interface [polypeptide binding]; other site 698967002960 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 698967002961 ligand binding site [chemical binding]; other site 698967002962 active site 698967002963 UGI interface [polypeptide binding]; other site 698967002964 catalytic site [active] 698967002965 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 698967002966 DAK2 domain; Region: Dak2; pfam02734 698967002967 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 698967002968 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 698967002969 generic binding surface II; other site 698967002970 ssDNA binding site; other site 698967002971 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698967002972 ATP binding site [chemical binding]; other site 698967002973 putative Mg++ binding site [ion binding]; other site 698967002974 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698967002975 nucleotide binding region [chemical binding]; other site 698967002976 ATP-binding site [chemical binding]; other site 698967002977 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 698967002978 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698967002979 carboxyltransferase (CT) interaction site; other site 698967002980 biotinylation site [posttranslational modification]; other site 698967002981 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 698967002982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698967002983 S-adenosylmethionine binding site [chemical binding]; other site 698967002984 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 698967002985 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 698967002986 active site 698967002987 (T/H)XGH motif; other site 698967002988 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698967002989 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698967002990 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698967002991 Walker A/P-loop; other site 698967002992 ATP binding site [chemical binding]; other site 698967002993 Q-loop/lid; other site 698967002994 ABC transporter signature motif; other site 698967002995 Walker B; other site 698967002996 D-loop; other site 698967002997 H-loop/switch region; other site 698967002998 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698967002999 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698967003000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698967003001 dimer interface [polypeptide binding]; other site 698967003002 conserved gate region; other site 698967003003 putative PBP binding loops; other site 698967003004 ABC-ATPase subunit interface; other site 698967003005 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698967003006 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698967003007 substrate binding pocket [chemical binding]; other site 698967003008 membrane-bound complex binding site; other site 698967003009 hinge residues; other site 698967003010 Domain of unknown function (DUF368); Region: DUF368; pfam04018 698967003011 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 698967003012 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698967003013 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698967003014 ATP binding site [chemical binding]; other site 698967003015 putative Mg++ binding site [ion binding]; other site 698967003016 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 698967003017 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698967003018 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698967003019 HsdM N-terminal domain; Region: HsdM_N; pfam12161 698967003020 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 698967003021 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698967003022 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698967003023 active site 698967003024 Int/Topo IB signature motif; other site 698967003025 catalytic residues [active] 698967003026 DNA binding site [nucleotide binding] 698967003027 potential frameshift: common BLAST hit: gi|38233854|ref|NP_939621.1| transposase 698967003028 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698967003029 HTH-like domain; Region: HTH_21; pfam13276 698967003030 Integrase core domain; Region: rve; pfam00665 698967003031 Integrase core domain; Region: rve_2; pfam13333 698967003032 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698967003033 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698967003034 MULE transposase domain; Region: MULE; pfam10551 698967003035 potential frameshift: common BLAST hit: gi|38233854|ref|NP_939621.1| transposase 698967003036 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698967003037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698967003038 HTH-like domain; Region: HTH_21; pfam13276 698967003039 Integrase core domain; Region: rve; pfam00665 698967003040 Integrase core domain; Region: rve_2; pfam13333 698967003041 MULE transposase domain; Region: MULE; pfam10551 698967003042 DNA polymerase I; Provisional; Region: PRK05755 698967003043 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 698967003044 active site 698967003045 metal binding site 1 [ion binding]; metal-binding site 698967003046 putative 5' ssDNA interaction site; other site 698967003047 metal binding site 3; metal-binding site 698967003048 metal binding site 2 [ion binding]; metal-binding site 698967003049 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 698967003050 putative DNA binding site [nucleotide binding]; other site 698967003051 putative metal binding site [ion binding]; other site 698967003052 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 698967003053 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 698967003054 active site 698967003055 DNA binding site [nucleotide binding] 698967003056 catalytic site [active] 698967003057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698967003058 S-adenosylmethionine binding site [chemical binding]; other site 698967003059 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 698967003060 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 698967003061 RNA binding site [nucleotide binding]; other site 698967003062 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 698967003063 RNA binding site [nucleotide binding]; other site 698967003064 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698967003065 RNA binding site [nucleotide binding]; other site 698967003066 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 698967003067 RNA binding site [nucleotide binding]; other site 698967003068 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 698967003069 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 698967003070 transcriptional antiterminator BglG; Provisional; Region: PRK09772 698967003071 CAT RNA binding domain; Region: CAT_RBD; smart01061 698967003072 PRD domain; Region: PRD; pfam00874 698967003073 PRD domain; Region: PRD; pfam00874 698967003074 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 698967003075 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698967003076 active site turn [active] 698967003077 phosphorylation site [posttranslational modification] 698967003078 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698967003079 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 698967003080 HPr interaction site; other site 698967003081 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698967003082 active site 698967003083 phosphorylation site [posttranslational modification] 698967003084 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 698967003085 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 698967003086 CoA-binding site [chemical binding]; other site 698967003087 ATP-binding [chemical binding]; other site 698967003088 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 698967003089 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698967003090 FeS/SAM binding site; other site 698967003091 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 698967003092 excinuclease ABC subunit B; Provisional; Region: PRK05298 698967003093 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698967003094 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698967003095 nucleotide binding region [chemical binding]; other site 698967003096 ATP-binding site [chemical binding]; other site 698967003097 Ultra-violet resistance protein B; Region: UvrB; pfam12344 698967003098 UvrB/uvrC motif; Region: UVR; pfam02151 698967003099 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698967003100 Ligand Binding Site [chemical binding]; other site 698967003101 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 698967003102 Part of AAA domain; Region: AAA_19; pfam13245 698967003103 PhoH-like protein; Region: PhoH; cl17668 698967003104 Family description; Region: UvrD_C_2; pfam13538 698967003105 Predicted membrane protein [Function unknown]; Region: COG2259 698967003106 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698967003107 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 698967003108 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698967003109 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698967003110 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 698967003111 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 698967003112 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 698967003113 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 698967003114 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 698967003115 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 698967003116 23S rRNA binding site [nucleotide binding]; other site 698967003117 L21 binding site [polypeptide binding]; other site 698967003118 L13 binding site [polypeptide binding]; other site 698967003119 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698967003120 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 698967003121 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698967003122 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 698967003123 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 698967003124 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 698967003125 dimer interface [polypeptide binding]; other site 698967003126 motif 1; other site 698967003127 active site 698967003128 motif 2; other site 698967003129 motif 3; other site 698967003130 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 698967003131 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 698967003132 putative tRNA-binding site [nucleotide binding]; other site 698967003133 B3/4 domain; Region: B3_4; pfam03483 698967003134 tRNA synthetase B5 domain; Region: B5; smart00874 698967003135 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 698967003136 dimer interface [polypeptide binding]; other site 698967003137 motif 1; other site 698967003138 motif 3; other site 698967003139 motif 2; other site 698967003140 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 698967003141 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 698967003142 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698967003143 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 698967003144 heterotetramer interface [polypeptide binding]; other site 698967003145 active site pocket [active] 698967003146 cleavage site 698967003147 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 698967003148 feedback inhibition sensing region; other site 698967003149 homohexameric interface [polypeptide binding]; other site 698967003150 nucleotide binding site [chemical binding]; other site 698967003151 N-acetyl-L-glutamate binding site [chemical binding]; other site 698967003152 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 698967003153 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698967003154 inhibitor-cofactor binding pocket; inhibition site 698967003155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698967003156 catalytic residue [active] 698967003157 ornithine carbamoyltransferase; Provisional; Region: PRK00779 698967003158 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698967003159 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698967003160 arginine repressor; Provisional; Region: PRK03341 698967003161 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 698967003162 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 698967003163 argininosuccinate synthase; Provisional; Region: PRK13820 698967003164 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 698967003165 ANP binding site [chemical binding]; other site 698967003166 Substrate Binding Site II [chemical binding]; other site 698967003167 Substrate Binding Site I [chemical binding]; other site 698967003168 argininosuccinate lyase; Provisional; Region: PRK00855 698967003169 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 698967003170 active sites [active] 698967003171 tetramer interface [polypeptide binding]; other site 698967003172 Uncharacterized conserved protein [Function unknown]; Region: COG2835 698967003173 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 698967003174 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 698967003175 active site 698967003176 HIGH motif; other site 698967003177 dimer interface [polypeptide binding]; other site 698967003178 KMSKS motif; other site 698967003179 S4 RNA-binding domain; Region: S4; smart00363 698967003180 RNA binding surface [nucleotide binding]; other site 698967003181 transcription termination factor Rho; Provisional; Region: PRK12678 698967003182 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698967003183 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698967003184 active site 698967003185 motif I; other site 698967003186 motif II; other site 698967003187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698967003188 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 698967003189 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698967003190 RNA binding surface [nucleotide binding]; other site 698967003191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698967003192 S-adenosylmethionine binding site [chemical binding]; other site 698967003193 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 698967003194 ATP-NAD kinase; Region: NAD_kinase; pfam01513 698967003195 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 698967003196 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698967003197 Walker A/P-loop; other site 698967003198 ATP binding site [chemical binding]; other site 698967003199 Q-loop/lid; other site 698967003200 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698967003201 ABC transporter signature motif; other site 698967003202 Walker B; other site 698967003203 D-loop; other site 698967003204 H-loop/switch region; other site 698967003205 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 698967003206 Thiamine pyrophosphokinase; Region: TPK; cl08415 698967003207 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 698967003208 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 698967003209 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 698967003210 dimer interface [polypeptide binding]; other site 698967003211 ADP-ribose binding site [chemical binding]; other site 698967003212 active site 698967003213 nudix motif; other site 698967003214 metal binding site [ion binding]; metal-binding site 698967003215 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 698967003216 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 698967003217 active site 698967003218 Int/Topo IB signature motif; other site 698967003219 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698967003220 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698967003221 P-loop; other site 698967003222 Magnesium ion binding site [ion binding]; other site 698967003223 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698967003224 Magnesium ion binding site [ion binding]; other site 698967003225 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 698967003226 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698967003227 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 698967003228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967003229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967003230 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 698967003231 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698967003232 inhibitor-cofactor binding pocket; inhibition site 698967003233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698967003234 catalytic residue [active] 698967003235 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698967003236 AAA domain; Region: AAA_26; pfam13500 698967003237 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 698967003238 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 698967003239 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698967003240 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698967003241 RNA binding surface [nucleotide binding]; other site 698967003242 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 698967003243 active site 698967003244 cytidylate kinase; Provisional; Region: cmk; PRK00023 698967003245 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 698967003246 CMP-binding site; other site 698967003247 The sites determining sugar specificity; other site 698967003248 GTP-binding protein Der; Reviewed; Region: PRK03003 698967003249 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 698967003250 G1 box; other site 698967003251 GTP/Mg2+ binding site [chemical binding]; other site 698967003252 Switch I region; other site 698967003253 G2 box; other site 698967003254 Switch II region; other site 698967003255 G3 box; other site 698967003256 G4 box; other site 698967003257 G5 box; other site 698967003258 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 698967003259 G1 box; other site 698967003260 GTP/Mg2+ binding site [chemical binding]; other site 698967003261 Switch I region; other site 698967003262 G2 box; other site 698967003263 G3 box; other site 698967003264 Switch II region; other site 698967003265 G4 box; other site 698967003266 G5 box; other site 698967003267 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698967003268 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 698967003269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698967003270 S-adenosylmethionine binding site [chemical binding]; other site 698967003271 Putative esterase; Region: Esterase; pfam00756 698967003272 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698967003273 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 698967003274 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698967003275 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 698967003276 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698967003277 nucleotide binding region [chemical binding]; other site 698967003278 ATP-binding site [chemical binding]; other site 698967003279 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698967003280 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698967003281 phosphopeptide binding site; other site 698967003282 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 698967003283 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698967003284 DNA binding residues [nucleotide binding] 698967003285 Bifunctional nuclease; Region: DNase-RNase; pfam02577 698967003286 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 698967003287 DNA binding residues [nucleotide binding] 698967003288 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698967003289 putative dimer interface [polypeptide binding]; other site 698967003290 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698967003291 metal ion-dependent adhesion site (MIDAS); other site 698967003292 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698967003293 Domain of unknown function DUF21; Region: DUF21; pfam01595 698967003294 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698967003295 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698967003296 Domain of unknown function DUF21; Region: DUF21; pfam01595 698967003297 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698967003298 Transporter associated domain; Region: CorC_HlyC; smart01091 698967003299 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 698967003300 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698967003301 ATP binding site [chemical binding]; other site 698967003302 Mg++ binding site [ion binding]; other site 698967003303 motif III; other site 698967003304 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698967003305 nucleotide binding region [chemical binding]; other site 698967003306 ATP-binding site [chemical binding]; other site 698967003307 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698967003308 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 698967003309 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 698967003310 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 698967003311 CoenzymeA binding site [chemical binding]; other site 698967003312 subunit interaction site [polypeptide binding]; other site 698967003313 PHB binding site; other site 698967003314 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 698967003315 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 698967003316 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 698967003317 oligomer interface [polypeptide binding]; other site 698967003318 metal binding site [ion binding]; metal-binding site 698967003319 metal binding site [ion binding]; metal-binding site 698967003320 putative Cl binding site [ion binding]; other site 698967003321 basic sphincter; other site 698967003322 hydrophobic gate; other site 698967003323 periplasmic entrance; other site 698967003324 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698967003325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698967003326 S-adenosylmethionine binding site [chemical binding]; other site 698967003327 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698967003328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698967003329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698967003330 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 698967003331 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698967003332 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698967003333 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698967003334 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 698967003335 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698967003336 FAD binding domain; Region: FAD_binding_4; pfam01565 698967003337 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698967003338 FAD binding domain; Region: FAD_binding_4; pfam01565 698967003339 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698967003340 Sodium Bile acid symporter family; Region: SBF; pfam01758 698967003341 YceI-like domain; Region: YceI; pfam04264 698967003342 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 698967003343 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 698967003344 Ligand binding site; other site 698967003345 Putative Catalytic site; other site 698967003346 DXD motif; other site 698967003347 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 698967003348 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 698967003349 putative active site [active] 698967003350 catalytic triad [active] 698967003351 putative dimer interface [polypeptide binding]; other site 698967003352 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 698967003353 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 698967003354 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698967003355 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698967003356 precorrin-3B synthase; Region: CobG; TIGR02435 698967003357 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698967003358 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698967003359 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 698967003360 Precorrin-8X methylmutase; Region: CbiC; pfam02570 698967003361 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 698967003362 active site 698967003363 SAM binding site [chemical binding]; other site 698967003364 homodimer interface [polypeptide binding]; other site 698967003365 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 698967003366 active site 698967003367 SAM binding site [chemical binding]; other site 698967003368 homodimer interface [polypeptide binding]; other site 698967003369 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 698967003370 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 698967003371 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 698967003372 active site 698967003373 SAM binding site [chemical binding]; other site 698967003374 homodimer interface [polypeptide binding]; other site 698967003375 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 698967003376 active site 698967003377 putative homodimer interface [polypeptide binding]; other site 698967003378 SAM binding site [chemical binding]; other site 698967003379 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 698967003380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698967003381 S-adenosylmethionine binding site [chemical binding]; other site 698967003382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698967003383 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698967003384 NAD(P) binding site [chemical binding]; other site 698967003385 active site 698967003386 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698967003387 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698967003388 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698967003389 active site 698967003390 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698967003391 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698967003392 ATP binding site [chemical binding]; other site 698967003393 putative Mg++ binding site [ion binding]; other site 698967003394 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698967003395 nucleotide binding region [chemical binding]; other site 698967003396 ATP-binding site [chemical binding]; other site 698967003397 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 698967003398 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 698967003399 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 698967003400 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 698967003401 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 698967003402 Predicted transcriptional regulator [Transcription]; Region: COG2378 698967003403 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 698967003404 WYL domain; Region: WYL; pfam13280 698967003405 WYL domain; Region: WYL; pfam13280 698967003406 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 698967003407 Pup-like protein; Region: Pup; pfam05639 698967003408 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 698967003409 proteasome ATPase; Region: pup_AAA; TIGR03689 698967003410 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698967003411 Walker A motif; other site 698967003412 ATP binding site [chemical binding]; other site 698967003413 Walker B motif; other site 698967003414 arginine finger; other site 698967003415 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 698967003416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698967003417 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 698967003418 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 698967003419 active site 698967003420 metal binding site [ion binding]; metal-binding site 698967003421 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 698967003422 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 698967003423 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 698967003424 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 698967003425 Potassium binding sites [ion binding]; other site 698967003426 Cesium cation binding sites [ion binding]; other site 698967003427 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 698967003428 Aspartase; Region: Aspartase; cd01357 698967003429 active sites [active] 698967003430 tetramer interface [polypeptide binding]; other site 698967003431 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698967003432 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 698967003433 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 698967003434 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 698967003435 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 698967003436 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 698967003437 homodimer interface [polypeptide binding]; other site 698967003438 putative metal binding site [ion binding]; other site 698967003439 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 698967003440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698967003441 motif II; other site 698967003442 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 698967003443 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 698967003444 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 698967003445 substrate binding pocket [chemical binding]; other site 698967003446 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 698967003447 B12 binding site [chemical binding]; other site 698967003448 cobalt ligand [ion binding]; other site 698967003449 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 698967003450 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 698967003451 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698967003452 active site 698967003453 HIGH motif; other site 698967003454 nucleotide binding site [chemical binding]; other site 698967003455 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698967003456 active site 698967003457 KMSKS motif; other site 698967003458 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698967003459 tRNA binding surface [nucleotide binding]; other site 698967003460 anticodon binding site; other site 698967003461 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 698967003462 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 698967003463 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 698967003464 quinone interaction residues [chemical binding]; other site 698967003465 active site 698967003466 catalytic residues [active] 698967003467 FMN binding site [chemical binding]; other site 698967003468 substrate binding site [chemical binding]; other site 698967003469 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 698967003470 substrate binding site [chemical binding]; other site 698967003471 potential frameshift: common BLAST hit: gi|38233854|ref|NP_939621.1| transposase 698967003472 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698967003473 HTH-like domain; Region: HTH_21; pfam13276 698967003474 Integrase core domain; Region: rve; pfam00665 698967003475 Integrase core domain; Region: rve_2; pfam13333 698967003476 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698967003477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698967003478 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698967003479 active site residue [active] 698967003480 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698967003481 active site residue [active] 698967003482 membrane ATPase/protein kinase; Provisional; Region: PRK09435 698967003483 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 698967003484 Walker A; other site 698967003485 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 698967003486 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 698967003487 active site 698967003488 substrate binding site [chemical binding]; other site 698967003489 coenzyme B12 binding site [chemical binding]; other site 698967003490 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 698967003491 B12 binding site [chemical binding]; other site 698967003492 cobalt ligand [ion binding]; other site 698967003493 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 698967003494 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 698967003495 heterodimer interface [polypeptide binding]; other site 698967003496 substrate interaction site [chemical binding]; other site 698967003497 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 698967003498 Uncharacterized conserved protein [Function unknown]; Region: COG0398 698967003499 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 698967003500 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698967003501 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 698967003502 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 698967003503 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 698967003504 ferrochelatase; Reviewed; Region: hemH; PRK00035 698967003505 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 698967003506 C-terminal domain interface [polypeptide binding]; other site 698967003507 active site 698967003508 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 698967003509 active site 698967003510 N-terminal domain interface [polypeptide binding]; other site 698967003511 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698967003512 NlpC/P60 family; Region: NLPC_P60; pfam00877 698967003513 aconitate hydratase; Validated; Region: PRK09277 698967003514 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698967003515 substrate binding site [chemical binding]; other site 698967003516 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698967003517 ligand binding site [chemical binding]; other site 698967003518 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 698967003519 substrate binding site [chemical binding]; other site 698967003520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698967003521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698967003522 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 698967003523 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 698967003524 catalytic triad [active] 698967003525 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 698967003526 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 698967003527 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698967003528 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698967003529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967003530 Walker A/P-loop; other site 698967003531 ATP binding site [chemical binding]; other site 698967003532 Q-loop/lid; other site 698967003533 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698967003534 ABC transporter signature motif; other site 698967003535 Walker B; other site 698967003536 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698967003537 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 698967003538 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 698967003539 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 698967003540 trimerization site [polypeptide binding]; other site 698967003541 active site 698967003542 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698967003543 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 698967003544 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698967003545 catalytic residue [active] 698967003546 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 698967003547 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 698967003548 Walker A/P-loop; other site 698967003549 ATP binding site [chemical binding]; other site 698967003550 Q-loop/lid; other site 698967003551 ABC transporter signature motif; other site 698967003552 Walker B; other site 698967003553 D-loop; other site 698967003554 H-loop/switch region; other site 698967003555 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 698967003556 FeS assembly protein SufD; Region: sufD; TIGR01981 698967003557 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 698967003558 FeS assembly protein SufB; Region: sufB; TIGR01980 698967003559 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698967003560 Predicted transcriptional regulator [Transcription]; Region: COG2345 698967003561 putative DNA binding site [nucleotide binding]; other site 698967003562 putative Zn2+ binding site [ion binding]; other site 698967003563 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698967003564 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698967003565 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698967003566 Walker A/P-loop; other site 698967003567 ATP binding site [chemical binding]; other site 698967003568 Q-loop/lid; other site 698967003569 ABC transporter signature motif; other site 698967003570 Walker B; other site 698967003571 D-loop; other site 698967003572 H-loop/switch region; other site 698967003573 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698967003574 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698967003575 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 698967003576 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 698967003577 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 698967003578 UbiA prenyltransferase family; Region: UbiA; pfam01040 698967003579 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 698967003580 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 698967003581 TPP-binding site [chemical binding]; other site 698967003582 dimer interface [polypeptide binding]; other site 698967003583 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698967003584 PYR/PP interface [polypeptide binding]; other site 698967003585 dimer interface [polypeptide binding]; other site 698967003586 TPP binding site [chemical binding]; other site 698967003587 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698967003588 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 698967003589 putative active site [active] 698967003590 transaldolase; Provisional; Region: PRK03903 698967003591 catalytic residue [active] 698967003592 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 698967003593 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 698967003594 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 698967003595 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 698967003596 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 698967003597 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698967003598 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 698967003599 putative active site [active] 698967003600 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 698967003601 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 698967003602 triosephosphate isomerase; Provisional; Region: PRK14567 698967003603 substrate binding site [chemical binding]; other site 698967003604 dimer interface [polypeptide binding]; other site 698967003605 catalytic triad [active] 698967003606 Phosphoglycerate kinase; Region: PGK; pfam00162 698967003607 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 698967003608 substrate binding site [chemical binding]; other site 698967003609 hinge regions; other site 698967003610 ADP binding site [chemical binding]; other site 698967003611 catalytic site [active] 698967003612 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 698967003613 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 698967003614 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698967003615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 698967003616 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 698967003617 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 698967003618 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 698967003619 phosphate binding site [ion binding]; other site 698967003620 putative substrate binding pocket [chemical binding]; other site 698967003621 dimer interface [polypeptide binding]; other site 698967003622 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 698967003623 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 698967003624 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 698967003625 GIY-YIG motif/motif A; other site 698967003626 active site 698967003627 catalytic site [active] 698967003628 putative DNA binding site [nucleotide binding]; other site 698967003629 metal binding site [ion binding]; metal-binding site 698967003630 UvrB/uvrC motif; Region: UVR; pfam02151 698967003631 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 698967003632 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698967003633 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 698967003634 homopentamer interface [polypeptide binding]; other site 698967003635 active site 698967003636 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 698967003637 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 698967003638 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 698967003639 dimerization interface [polypeptide binding]; other site 698967003640 active site 698967003641 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 698967003642 Lumazine binding domain; Region: Lum_binding; pfam00677 698967003643 Lumazine binding domain; Region: Lum_binding; pfam00677 698967003644 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 698967003645 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 698967003646 catalytic motif [active] 698967003647 Zn binding site [ion binding]; other site 698967003648 RibD C-terminal domain; Region: RibD_C; pfam01872 698967003649 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 698967003650 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 698967003651 substrate binding site [chemical binding]; other site 698967003652 hexamer interface [polypeptide binding]; other site 698967003653 metal binding site [ion binding]; metal-binding site 698967003654 16S rRNA methyltransferase B; Provisional; Region: PRK14902 698967003655 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 698967003656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698967003657 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 698967003658 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 698967003659 putative active site [active] 698967003660 substrate binding site [chemical binding]; other site 698967003661 putative cosubstrate binding site; other site 698967003662 catalytic site [active] 698967003663 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 698967003664 substrate binding site [chemical binding]; other site 698967003665 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698967003666 active site 698967003667 catalytic residues [active] 698967003668 metal binding site [ion binding]; metal-binding site 698967003669 primosome assembly protein PriA; Provisional; Region: PRK14873 698967003670 S-adenosylmethionine synthetase; Validated; Region: PRK05250 698967003671 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 698967003672 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 698967003673 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 698967003674 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 698967003675 Flavoprotein; Region: Flavoprotein; pfam02441 698967003676 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 698967003677 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 698967003678 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 698967003679 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 698967003680 catalytic site [active] 698967003681 G-X2-G-X-G-K; other site 698967003682 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 698967003683 active site 698967003684 dimer interface [polypeptide binding]; other site 698967003685 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 698967003686 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698967003687 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698967003688 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 698967003689 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698967003690 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698967003691 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 698967003692 IMP binding site; other site 698967003693 dimer interface [polypeptide binding]; other site 698967003694 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 698967003695 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 698967003696 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 698967003697 catalytic site [active] 698967003698 subunit interface [polypeptide binding]; other site 698967003699 dihydroorotase; Validated; Region: pyrC; PRK09357 698967003700 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698967003701 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 698967003702 active site 698967003703 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 698967003704 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698967003705 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698967003706 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 698967003707 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698967003708 active site 698967003709 hydrophobic ligand binding site; other site 698967003710 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698967003711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698967003712 TIGR01777 family protein; Region: yfcH 698967003713 NAD(P) binding site [chemical binding]; other site 698967003714 active site 698967003715 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 698967003716 elongation factor P; Validated; Region: PRK00529 698967003717 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 698967003718 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 698967003719 RNA binding site [nucleotide binding]; other site 698967003720 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 698967003721 RNA binding site [nucleotide binding]; other site 698967003722 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698967003723 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698967003724 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698967003725 active site 698967003726 Dehydroquinase class II; Region: DHquinase_II; pfam01220 698967003727 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 698967003728 trimer interface [polypeptide binding]; other site 698967003729 active site 698967003730 dimer interface [polypeptide binding]; other site 698967003731 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 698967003732 active site 698967003733 dimer interface [polypeptide binding]; other site 698967003734 metal binding site [ion binding]; metal-binding site 698967003735 shikimate kinase; Reviewed; Region: aroK; PRK00131 698967003736 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 698967003737 ADP binding site [chemical binding]; other site 698967003738 magnesium binding site [ion binding]; other site 698967003739 putative shikimate binding site; other site 698967003740 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 698967003741 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 698967003742 Tetramer interface [polypeptide binding]; other site 698967003743 active site 698967003744 FMN-binding site [chemical binding]; other site 698967003745 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 698967003746 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698967003747 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698967003748 shikimate binding site; other site 698967003749 NAD(P) binding site [chemical binding]; other site 698967003750 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 698967003751 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 698967003752 dimerization interface [polypeptide binding]; other site 698967003753 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 698967003754 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 698967003755 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 698967003756 motif 1; other site 698967003757 active site 698967003758 motif 2; other site 698967003759 motif 3; other site 698967003760 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698967003761 DHHA1 domain; Region: DHHA1; pfam02272 698967003762 recombination factor protein RarA; Reviewed; Region: PRK13342 698967003763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698967003764 Walker A motif; other site 698967003765 ATP binding site [chemical binding]; other site 698967003766 Walker B motif; other site 698967003767 arginine finger; other site 698967003768 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 698967003769 Phosphotransferase enzyme family; Region: APH; pfam01636 698967003770 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698967003771 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 698967003772 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 698967003773 dimer interface [polypeptide binding]; other site 698967003774 anticodon binding site; other site 698967003775 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 698967003776 homodimer interface [polypeptide binding]; other site 698967003777 motif 1; other site 698967003778 active site 698967003779 motif 2; other site 698967003780 GAD domain; Region: GAD; pfam02938 698967003781 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698967003782 active site 698967003783 motif 3; other site 698967003784 Predicted metalloprotease [General function prediction only]; Region: COG2321 698967003785 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 698967003786 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698967003787 ATP binding site [chemical binding]; other site 698967003788 putative Mg++ binding site [ion binding]; other site 698967003789 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698967003790 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 698967003791 nucleotide binding region [chemical binding]; other site 698967003792 ATP-binding site [chemical binding]; other site 698967003793 Predicted membrane protein [Function unknown]; Region: COG1511 698967003794 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698967003795 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698967003796 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698967003797 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698967003798 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698967003799 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967003800 Q-loop/lid; other site 698967003801 ABC transporter signature motif; other site 698967003802 Walker B; other site 698967003803 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698967003804 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698967003805 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 698967003806 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 698967003807 dimer interface [polypeptide binding]; other site 698967003808 motif 1; other site 698967003809 active site 698967003810 motif 2; other site 698967003811 motif 3; other site 698967003812 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 698967003813 anticodon binding site; other site 698967003814 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698967003815 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 698967003816 dimer interface [polypeptide binding]; other site 698967003817 catalytic triad [active] 698967003818 peroxidatic and resolving cysteines [active] 698967003819 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698967003820 active site 698967003821 MULE transposase domain; Region: MULE; pfam10551 698967003822 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698967003823 MULE transposase domain; Region: MULE; pfam10551 698967003824 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698967003825 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698967003826 Zn2+ binding site [ion binding]; other site 698967003827 Mg2+ binding site [ion binding]; other site 698967003828 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698967003829 synthetase active site [active] 698967003830 NTP binding site [chemical binding]; other site 698967003831 metal binding site [ion binding]; metal-binding site 698967003832 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 698967003833 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 698967003834 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698967003835 active site 698967003836 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 698967003837 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698967003838 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 698967003839 Protein export membrane protein; Region: SecD_SecF; cl14618 698967003840 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 698967003841 Protein export membrane protein; Region: SecD_SecF; cl14618 698967003842 Preprotein translocase subunit; Region: YajC; pfam02699 698967003843 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 698967003844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698967003845 Walker A motif; other site 698967003846 ATP binding site [chemical binding]; other site 698967003847 Walker B motif; other site 698967003848 arginine finger; other site 698967003849 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 698967003850 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 698967003851 RuvA N terminal domain; Region: RuvA_N; pfam01330 698967003852 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 698967003853 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 698967003854 active site 698967003855 putative DNA-binding cleft [nucleotide binding]; other site 698967003856 dimer interface [polypeptide binding]; other site 698967003857 hypothetical protein; Validated; Region: PRK00110 698967003858 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 698967003859 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 698967003860 active site 698967003861 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 698967003862 catalytic triad [active] 698967003863 dimer interface [polypeptide binding]; other site 698967003864 Integrase core domain; Region: rve; pfam00665 698967003865 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698967003866 Helix-turn-helix domain; Region: HTH_38; pfam13936 698967003867 Integrase core domain; Region: rve; pfam00665 698967003868 Integrase core domain; Region: rve_3; cl15866 698967003869 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 698967003870 FMN binding site [chemical binding]; other site 698967003871 substrate binding site [chemical binding]; other site 698967003872 putative catalytic residue [active] 698967003873 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 698967003874 Replicase family; Region: Replicase; pfam03090 698967003875 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 698967003876 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698967003877 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698967003878 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698967003879 catalytic residues [active] 698967003880 catalytic nucleophile [active] 698967003881 Presynaptic Site I dimer interface [polypeptide binding]; other site 698967003882 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698967003883 Synaptic Flat tetramer interface [polypeptide binding]; other site 698967003884 Synaptic Site I dimer interface [polypeptide binding]; other site 698967003885 DNA binding site [nucleotide binding] 698967003886 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698967003887 MULE transposase domain; Region: MULE; pfam10551 698967003888 potential frameshift: common BLAST hit: gi|68536874|ref|YP_251579.1| transposase IS3525 698967003889 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698967003890 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698967003891 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698967003892 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 698967003893 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 698967003894 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698967003895 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698967003896 catalytic residue [active] 698967003897 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698967003898 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698967003899 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 698967003900 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 698967003901 putative acyl-acceptor binding pocket; other site 698967003902 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698967003903 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 698967003904 nucleotide binding site/active site [active] 698967003905 HIT family signature motif; other site 698967003906 catalytic residue [active] 698967003907 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 698967003908 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698967003909 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 698967003910 active site 698967003911 dimer interface [polypeptide binding]; other site 698967003912 motif 1; other site 698967003913 motif 2; other site 698967003914 motif 3; other site 698967003915 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 698967003916 anticodon binding site; other site 698967003917 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 698967003918 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 698967003919 Protein of unknown function (DUF461); Region: DUF461; pfam04314 698967003920 CopC domain; Region: CopC; cl01012 698967003921 potential frameshift: common BLAST hit: gi|38233854|ref|NP_939621.1| transposase 698967003922 HTH-like domain; Region: HTH_21; pfam13276 698967003923 Integrase core domain; Region: rve; pfam00665 698967003924 Integrase core domain; Region: rve_2; pfam13333 698967003925 hypothetical protein; Provisional; Region: PRK14059 698967003926 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 698967003927 SelR domain; Region: SelR; pfam01641 698967003928 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 698967003929 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 698967003930 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 698967003931 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 698967003932 catalytic site [active] 698967003933 putative active site [active] 698967003934 putative substrate binding site [chemical binding]; other site 698967003935 HRDC domain; Region: HRDC; pfam00570 698967003936 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 698967003937 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 698967003938 TPP-binding site; other site 698967003939 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698967003940 PYR/PP interface [polypeptide binding]; other site 698967003941 dimer interface [polypeptide binding]; other site 698967003942 TPP binding site [chemical binding]; other site 698967003943 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698967003944 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 698967003945 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 698967003946 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 698967003947 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698967003948 trimer interface [polypeptide binding]; other site 698967003949 active site 698967003950 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 698967003951 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 698967003952 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698967003953 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 698967003954 active site 698967003955 dimerization interface [polypeptide binding]; other site 698967003956 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698967003957 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698967003958 nucleotide binding site [chemical binding]; other site 698967003959 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698967003960 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698967003961 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698967003962 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698967003963 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698967003964 DNA binding residues [nucleotide binding] 698967003965 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698967003966 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698967003967 ATP binding site [chemical binding]; other site 698967003968 putative Mg++ binding site [ion binding]; other site 698967003969 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 698967003970 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 698967003971 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 698967003972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698967003973 S-adenosylmethionine binding site [chemical binding]; other site 698967003974 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 698967003975 putative active site [active] 698967003976 dimerization interface [polypeptide binding]; other site 698967003977 putative tRNAtyr binding site [nucleotide binding]; other site 698967003978 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698967003979 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698967003980 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698967003981 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698967003982 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698967003983 DNA binding residues [nucleotide binding] 698967003984 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698967003985 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698967003986 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698967003987 FeoA domain; Region: FeoA; cl00838 698967003988 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 698967003989 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 698967003990 NAD binding site [chemical binding]; other site 698967003991 homodimer interface [polypeptide binding]; other site 698967003992 active site 698967003993 substrate binding site [chemical binding]; other site 698967003994 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 698967003995 PAC2 family; Region: PAC2; pfam09754 698967003996 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698967003997 ATP binding site [chemical binding]; other site 698967003998 putative Mg++ binding site [ion binding]; other site 698967003999 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698967004000 nucleotide binding region [chemical binding]; other site 698967004001 ATP-binding site [chemical binding]; other site 698967004002 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 698967004003 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 698967004004 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 698967004005 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698967004006 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 698967004007 dimer interface [polypeptide binding]; other site 698967004008 decamer (pentamer of dimers) interface [polypeptide binding]; other site 698967004009 catalytic triad [active] 698967004010 peroxidatic and resolving cysteines [active] 698967004011 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698967004012 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 698967004013 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 698967004014 dimerization interface [polypeptide binding]; other site 698967004015 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 698967004016 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698967004017 ATP binding site [chemical binding]; other site 698967004018 putative Mg++ binding site [ion binding]; other site 698967004019 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698967004020 nucleotide binding region [chemical binding]; other site 698967004021 ATP-binding site [chemical binding]; other site 698967004022 Helicase associated domain (HA2); Region: HA2; pfam04408 698967004023 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 698967004024 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 698967004025 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 698967004026 ATP cone domain; Region: ATP-cone; pfam03477 698967004027 LexA repressor; Validated; Region: PRK00215 698967004028 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 698967004029 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698967004030 Catalytic site [active] 698967004031 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698967004032 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 698967004033 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698967004034 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 698967004035 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 698967004036 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 698967004037 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 698967004038 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698967004039 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698967004040 DNA-binding site [nucleotide binding]; DNA binding site 698967004041 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698967004042 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 698967004043 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 698967004044 putative substrate binding site [chemical binding]; other site 698967004045 putative ATP binding site [chemical binding]; other site 698967004046 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698967004047 dimerization domain swap beta strand [polypeptide binding]; other site 698967004048 regulatory protein interface [polypeptide binding]; other site 698967004049 active site 698967004050 regulatory phosphorylation site [posttranslational modification]; other site 698967004051 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 698967004052 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698967004053 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 698967004054 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698967004055 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 698967004056 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 698967004057 GTPases [General function prediction only]; Region: HflX; COG2262 698967004058 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 698967004059 HflX GTPase family; Region: HflX; cd01878 698967004060 G1 box; other site 698967004061 GTP/Mg2+ binding site [chemical binding]; other site 698967004062 Switch I region; other site 698967004063 G2 box; other site 698967004064 G3 box; other site 698967004065 Switch II region; other site 698967004066 G4 box; other site 698967004067 G5 box; other site 698967004068 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 698967004069 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698967004070 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698967004071 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 698967004072 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 698967004073 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698967004074 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698967004075 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698967004076 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698967004077 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 698967004078 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 698967004079 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698967004080 FeS/SAM binding site; other site 698967004081 recombination regulator RecX; Reviewed; Region: recX; PRK00117 698967004082 recombinase A; Provisional; Region: recA; PRK09354 698967004083 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 698967004084 hexamer interface [polypeptide binding]; other site 698967004085 Walker A motif; other site 698967004086 ATP binding site [chemical binding]; other site 698967004087 Walker B motif; other site 698967004088 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 698967004089 BioY family; Region: BioY; pfam02632 698967004090 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698967004091 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698967004092 Walker A/P-loop; other site 698967004093 ATP binding site [chemical binding]; other site 698967004094 Q-loop/lid; other site 698967004095 ABC transporter signature motif; other site 698967004096 Walker B; other site 698967004097 D-loop; other site 698967004098 H-loop/switch region; other site 698967004099 Cobalt transport protein; Region: CbiQ; cl00463 698967004100 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698967004101 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698967004102 sequence-specific DNA binding site [nucleotide binding]; other site 698967004103 salt bridge; other site 698967004104 Competence-damaged protein; Region: CinA; pfam02464 698967004105 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698967004106 YCII-related domain; Region: YCII; cl00999 698967004107 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 698967004108 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 698967004109 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698967004110 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 698967004111 TIGR03085 family protein; Region: TIGR03085 698967004112 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 698967004113 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698967004114 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 698967004115 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 698967004116 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698967004117 dimer interface [polypeptide binding]; other site 698967004118 active site 698967004119 catalytic residue [active] 698967004120 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 698967004121 dihydrodipicolinate reductase; Provisional; Region: PRK00048 698967004122 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 698967004123 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 698967004124 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 698967004125 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 698967004126 oligomer interface [polypeptide binding]; other site 698967004127 RNA binding site [nucleotide binding]; other site 698967004128 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 698967004129 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 698967004130 RNase E interface [polypeptide binding]; other site 698967004131 trimer interface [polypeptide binding]; other site 698967004132 active site 698967004133 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 698967004134 putative nucleic acid binding region [nucleotide binding]; other site 698967004135 G-X-X-G motif; other site 698967004136 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 698967004137 RNA binding site [nucleotide binding]; other site 698967004138 domain interface; other site 698967004139 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 698967004140 16S/18S rRNA binding site [nucleotide binding]; other site 698967004141 S13e-L30e interaction site [polypeptide binding]; other site 698967004142 25S rRNA binding site [nucleotide binding]; other site 698967004143 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 698967004144 active site 698967004145 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 698967004146 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 698967004147 active site 698967004148 Riboflavin kinase; Region: Flavokinase; smart00904 698967004149 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 698967004150 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 698967004151 RNA binding site [nucleotide binding]; other site 698967004152 active site 698967004153 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 698967004154 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 698967004155 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 698967004156 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698967004157 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698967004158 active site 698967004159 metal binding site [ion binding]; metal-binding site 698967004160 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698967004161 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 698967004162 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 698967004163 DHH family; Region: DHH; pfam01368 698967004164 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 698967004165 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698967004166 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698967004167 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 698967004168 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 698967004169 G1 box; other site 698967004170 putative GEF interaction site [polypeptide binding]; other site 698967004171 GTP/Mg2+ binding site [chemical binding]; other site 698967004172 Switch I region; other site 698967004173 G2 box; other site 698967004174 G3 box; other site 698967004175 Switch II region; other site 698967004176 G4 box; other site 698967004177 G5 box; other site 698967004178 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 698967004179 Translation-initiation factor 2; Region: IF-2; pfam11987 698967004180 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 698967004181 Protein of unknown function (DUF448); Region: DUF448; pfam04296 698967004182 putative RNA binding cleft [nucleotide binding]; other site 698967004183 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 698967004184 NusA N-terminal domain; Region: NusA_N; pfam08529 698967004185 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 698967004186 RNA binding site [nucleotide binding]; other site 698967004187 homodimer interface [polypeptide binding]; other site 698967004188 NusA-like KH domain; Region: KH_5; pfam13184 698967004189 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 698967004190 G-X-X-G motif; other site 698967004191 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 698967004192 Sm and related proteins; Region: Sm_like; cl00259 698967004193 prolyl-tRNA synthetase; Provisional; Region: PRK09194 698967004194 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 698967004195 dimer interface [polypeptide binding]; other site 698967004196 motif 1; other site 698967004197 active site 698967004198 motif 2; other site 698967004199 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 698967004200 putative deacylase active site [active] 698967004201 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698967004202 active site 698967004203 motif 3; other site 698967004204 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 698967004205 anticodon binding site; other site 698967004206 hypothetical protein; Validated; Region: PRK02101 698967004207 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 698967004208 active site 698967004209 SAM binding site [chemical binding]; other site 698967004210 homodimer interface [polypeptide binding]; other site 698967004211 Uncharacterized conserved protein [Function unknown]; Region: COG0397 698967004212 hypothetical protein; Validated; Region: PRK00029 698967004213 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698967004214 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 698967004215 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 698967004216 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 698967004217 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698967004218 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 698967004219 catalytic triad [active] 698967004220 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 698967004221 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 698967004222 Walker A motif; other site 698967004223 homodimer interface [polypeptide binding]; other site 698967004224 ATP binding site [chemical binding]; other site 698967004225 hydroxycobalamin binding site [chemical binding]; other site 698967004226 Walker B motif; other site 698967004227 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 698967004228 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 698967004229 metal ion-dependent adhesion site (MIDAS); other site 698967004230 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 698967004231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698967004232 Walker A motif; other site 698967004233 ATP binding site [chemical binding]; other site 698967004234 Walker B motif; other site 698967004235 arginine finger; other site 698967004236 malate:quinone oxidoreductase; Validated; Region: PRK05257 698967004237 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 698967004238 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698967004239 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698967004240 mycothione reductase; Region: mycothione_red; TIGR03452 698967004241 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698967004242 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698967004243 cobyric acid synthase; Provisional; Region: PRK00784 698967004244 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 698967004245 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698967004246 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698967004247 catalytic triad [active] 698967004248 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698967004249 active site 698967004250 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 698967004251 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698967004252 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 698967004253 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698967004254 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698967004255 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 698967004256 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698967004257 active site 698967004258 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 698967004259 protein binding site [polypeptide binding]; other site 698967004260 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 698967004261 putative substrate binding region [chemical binding]; other site 698967004262 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 698967004263 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 698967004264 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 698967004265 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 698967004266 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 698967004267 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 698967004268 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698967004269 FeS/SAM binding site; other site 698967004270 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 698967004271 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 698967004272 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 698967004273 ribosome recycling factor; Reviewed; Region: frr; PRK00083 698967004274 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 698967004275 hinge region; other site 698967004276 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 698967004277 putative nucleotide binding site [chemical binding]; other site 698967004278 uridine monophosphate binding site [chemical binding]; other site 698967004279 homohexameric interface [polypeptide binding]; other site 698967004280 elongation factor Ts; Provisional; Region: tsf; PRK09377 698967004281 UBA/TS-N domain; Region: UBA; pfam00627 698967004282 Elongation factor TS; Region: EF_TS; pfam00889 698967004283 Elongation factor TS; Region: EF_TS; pfam00889 698967004284 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 698967004285 rRNA interaction site [nucleotide binding]; other site 698967004286 S8 interaction site; other site 698967004287 putative laminin-1 binding site; other site 698967004288 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698967004289 Peptidase family M23; Region: Peptidase_M23; pfam01551 698967004290 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698967004291 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 698967004292 active site 698967004293 DNA binding site [nucleotide binding] 698967004294 Int/Topo IB signature motif; other site 698967004295 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 698967004296 DNA protecting protein DprA; Region: dprA; TIGR00732 698967004297 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 698967004298 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698967004299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698967004300 Walker A motif; other site 698967004301 ATP binding site [chemical binding]; other site 698967004302 Walker B motif; other site 698967004303 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 698967004304 hypothetical protein; Reviewed; Region: PRK12497 698967004305 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 698967004306 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 698967004307 RNA/DNA hybrid binding site [nucleotide binding]; other site 698967004308 active site 698967004309 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 698967004310 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698967004311 Catalytic site [active] 698967004312 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698967004313 Htaa; Region: HtaA; pfam04213 698967004314 Htaa; Region: HtaA; pfam04213 698967004315 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 698967004316 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 698967004317 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 698967004318 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 698967004319 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698967004320 RNA binding site [nucleotide binding]; other site 698967004321 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 698967004322 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 698967004323 RimM N-terminal domain; Region: RimM; pfam01782 698967004324 PRC-barrel domain; Region: PRC; pfam05239 698967004325 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 698967004326 signal recognition particle protein; Provisional; Region: PRK10867 698967004327 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 698967004328 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 698967004329 P loop; other site 698967004330 GTP binding site [chemical binding]; other site 698967004331 Signal peptide binding domain; Region: SRP_SPB; pfam02978 698967004332 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 698967004333 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698967004334 metal binding triad; other site 698967004335 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698967004336 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 698967004337 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 698967004338 Nitrogen regulatory protein P-II; Region: P-II; smart00938 698967004339 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 698967004340 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 698967004341 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 698967004342 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698967004343 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 698967004344 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698967004345 Walker A/P-loop; other site 698967004346 ATP binding site [chemical binding]; other site 698967004347 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 698967004348 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698967004349 ABC transporter signature motif; other site 698967004350 Walker B; other site 698967004351 D-loop; other site 698967004352 H-loop/switch region; other site 698967004353 Acylphosphatase; Region: Acylphosphatase; cl00551 698967004354 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698967004355 amino acid carrier protein; Region: agcS; TIGR00835 698967004356 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 698967004357 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 698967004358 DNA binding site [nucleotide binding] 698967004359 catalytic residue [active] 698967004360 H2TH interface [polypeptide binding]; other site 698967004361 putative catalytic residues [active] 698967004362 turnover-facilitating residue; other site 698967004363 intercalation triad [nucleotide binding]; other site 698967004364 8OG recognition residue [nucleotide binding]; other site 698967004365 putative reading head residues; other site 698967004366 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698967004367 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698967004368 ribonuclease III; Reviewed; Region: rnc; PRK00102 698967004369 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 698967004370 dimerization interface [polypeptide binding]; other site 698967004371 active site 698967004372 metal binding site [ion binding]; metal-binding site 698967004373 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 698967004374 dsRNA binding site [nucleotide binding]; other site 698967004375 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 698967004376 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698967004377 glutamate dehydrogenase; Provisional; Region: PRK09414 698967004378 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 698967004379 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 698967004380 NAD(P) binding site [chemical binding]; other site 698967004381 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 698967004382 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698967004383 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698967004384 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 698967004385 metal binding site [ion binding]; metal-binding site 698967004386 putative dimer interface [polypeptide binding]; other site 698967004387 pyruvate kinase; Provisional; Region: PRK06247 698967004388 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 698967004389 domain interfaces; other site 698967004390 active site 698967004391 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 698967004392 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698967004393 active site 698967004394 ribulose/triose binding site [chemical binding]; other site 698967004395 phosphate binding site [ion binding]; other site 698967004396 substrate (anthranilate) binding pocket [chemical binding]; other site 698967004397 product (indole) binding pocket [chemical binding]; other site 698967004398 trp region conserved hypothetical membrane protein; Region: trp_oprn_chp; TIGR02234 698967004399 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 698967004400 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 698967004401 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698967004402 substrate binding site [chemical binding]; other site 698967004403 glutamase interaction surface [polypeptide binding]; other site 698967004404 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698967004405 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698967004406 active site 698967004407 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 698967004408 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698967004409 catalytic residues [active] 698967004410 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 698967004411 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 698967004412 putative active site [active] 698967004413 oxyanion strand; other site 698967004414 catalytic triad [active] 698967004415 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698967004416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967004417 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 698967004418 putative active site pocket [active] 698967004419 4-fold oligomerization interface [polypeptide binding]; other site 698967004420 metal binding residues [ion binding]; metal-binding site 698967004421 3-fold/trimer interface [polypeptide binding]; other site 698967004422 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 698967004423 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698967004424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698967004425 homodimer interface [polypeptide binding]; other site 698967004426 catalytic residue [active] 698967004427 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 698967004428 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 698967004429 NAD binding site [chemical binding]; other site 698967004430 dimerization interface [polypeptide binding]; other site 698967004431 product binding site; other site 698967004432 substrate binding site [chemical binding]; other site 698967004433 zinc binding site [ion binding]; other site 698967004434 catalytic residues [active] 698967004435 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 698967004436 tetracycline repressor protein TetR; Provisional; Region: PRK13756 698967004437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698967004438 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 698967004439 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 698967004440 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 698967004441 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 698967004442 active site 698967004443 catalytic site [active] 698967004444 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 698967004445 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 698967004446 active site 698967004447 catalytic site [active] 698967004448 substrate binding site [chemical binding]; other site 698967004449 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698967004450 synthetase active site [active] 698967004451 NTP binding site [chemical binding]; other site 698967004452 metal binding site [ion binding]; metal-binding site 698967004453 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698967004454 RNA binding surface [nucleotide binding]; other site 698967004455 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 698967004456 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 698967004457 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 698967004458 threonine dehydratase; Validated; Region: PRK08639 698967004459 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698967004460 tetramer interface [polypeptide binding]; other site 698967004461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698967004462 catalytic residue [active] 698967004463 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 698967004464 putative Ile/Val binding site [chemical binding]; other site 698967004465 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 698967004466 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 698967004467 active site 698967004468 PHP Thumb interface [polypeptide binding]; other site 698967004469 metal binding site [ion binding]; metal-binding site 698967004470 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698967004471 generic binding surface II; other site 698967004472 generic binding surface I; other site 698967004473 Predicted permeases [General function prediction only]; Region: RarD; COG2962 698967004474 EamA-like transporter family; Region: EamA; cl17759 698967004475 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 698967004476 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698967004477 RNA binding surface [nucleotide binding]; other site 698967004478 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698967004479 active site 698967004480 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 698967004481 lipoprotein signal peptidase; Provisional; Region: PRK14787 698967004482 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698967004483 active site 698967004484 homotetramer interface [polypeptide binding]; other site 698967004485 homodimer interface [polypeptide binding]; other site 698967004486 DNA polymerase IV; Provisional; Region: PRK03348 698967004487 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 698967004488 active site 698967004489 DNA binding site [nucleotide binding] 698967004490 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 698967004491 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698967004492 HIGH motif; other site 698967004493 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698967004494 active site 698967004495 KMSKS motif; other site 698967004496 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 698967004497 tRNA binding surface [nucleotide binding]; other site 698967004498 anticodon binding site; other site 698967004499 DivIVA domain; Region: DivI1A_domain; TIGR03544 698967004500 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698967004501 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 698967004502 YGGT family; Region: YGGT; cl00508 698967004503 Protein of unknown function (DUF552); Region: DUF552; cl00775 698967004504 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 698967004505 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 698967004506 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 698967004507 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 698967004508 nucleotide binding site [chemical binding]; other site 698967004509 SulA interaction site; other site 698967004510 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 698967004511 Cell division protein FtsQ; Region: FtsQ; pfam03799 698967004512 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 698967004513 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698967004514 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698967004515 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698967004516 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 698967004517 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 698967004518 active site 698967004519 homodimer interface [polypeptide binding]; other site 698967004520 cell division protein FtsW; Region: ftsW; TIGR02614 698967004521 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 698967004522 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698967004523 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698967004524 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 698967004525 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 698967004526 Mg++ binding site [ion binding]; other site 698967004527 putative catalytic motif [active] 698967004528 putative substrate binding site [chemical binding]; other site 698967004529 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 698967004530 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698967004531 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698967004532 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698967004533 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 698967004534 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698967004535 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698967004536 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698967004537 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698967004538 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698967004539 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698967004540 MraW methylase family; Region: Methyltransf_5; cl17771 698967004541 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 698967004542 cell division protein MraZ; Reviewed; Region: PRK00326 698967004543 MraZ protein; Region: MraZ; pfam02381 698967004544 MraZ protein; Region: MraZ; pfam02381 698967004545 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 698967004546 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698967004547 Coenzyme A binding pocket [chemical binding]; other site 698967004548 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 698967004549 FAD binding site [chemical binding]; other site 698967004550 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698967004551 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698967004552 substrate binding pocket [chemical binding]; other site 698967004553 chain length determination region; other site 698967004554 substrate-Mg2+ binding site; other site 698967004555 catalytic residues [active] 698967004556 aspartate-rich region 1; other site 698967004557 active site lid residues [active] 698967004558 aspartate-rich region 2; other site 698967004559 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698967004560 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 698967004561 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698967004562 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698967004563 active site 698967004564 ATP binding site [chemical binding]; other site 698967004565 substrate binding site [chemical binding]; other site 698967004566 activation loop (A-loop); other site 698967004567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698967004568 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698967004569 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698967004570 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698967004571 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698967004572 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 698967004573 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698967004574 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698967004575 putative acyl-acceptor binding pocket; other site 698967004576 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698967004577 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698967004578 nucleotide binding site [chemical binding]; other site 698967004579 Tesmin/TSO1-like CXC domain; Region: CXC; pfam03638 698967004580 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698967004581 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698967004582 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698967004583 NlpC/P60 family; Region: NLPC_P60; pfam00877 698967004584 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698967004585 NlpC/P60 family; Region: NLPC_P60; pfam00877 698967004586 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 698967004587 heme bH binding site [chemical binding]; other site 698967004588 intrachain domain interface; other site 698967004589 heme bL binding site [chemical binding]; other site 698967004590 interchain domain interface [polypeptide binding]; other site 698967004591 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 698967004592 Qo binding site; other site 698967004593 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 698967004594 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698967004595 iron-sulfur cluster [ion binding]; other site 698967004596 [2Fe-2S] cluster binding site [ion binding]; other site 698967004597 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698967004598 Cytochrome c; Region: Cytochrom_C; pfam00034 698967004599 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698967004600 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 698967004601 Subunit I/III interface [polypeptide binding]; other site 698967004602 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 698967004603 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 698967004604 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 698967004605 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 698967004606 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 698967004607 active site 698967004608 dimer interface [polypeptide binding]; other site 698967004609 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 698967004610 Ligand Binding Site [chemical binding]; other site 698967004611 Molecular Tunnel; other site 698967004612 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 698967004613 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 698967004614 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 698967004615 homotrimer interface [polypeptide binding]; other site 698967004616 Walker A motif; other site 698967004617 GTP binding site [chemical binding]; other site 698967004618 Walker B motif; other site 698967004619 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 698967004620 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 698967004621 putative dimer interface [polypeptide binding]; other site 698967004622 active site pocket [active] 698967004623 putative cataytic base [active] 698967004624 cobalamin synthase; Reviewed; Region: cobS; PRK00235 698967004625 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 698967004626 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 698967004627 homodimer interface [polypeptide binding]; other site 698967004628 substrate-cofactor binding pocket; other site 698967004629 catalytic residue [active] 698967004630 multifunctional aminopeptidase A; Provisional; Region: PRK00913 698967004631 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 698967004632 interface (dimer of trimers) [polypeptide binding]; other site 698967004633 Substrate-binding/catalytic site; other site 698967004634 Zn-binding sites [ion binding]; other site 698967004635 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 698967004636 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698967004637 E3 interaction surface; other site 698967004638 lipoyl attachment site [posttranslational modification]; other site 698967004639 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698967004640 E3 interaction surface; other site 698967004641 lipoyl attachment site [posttranslational modification]; other site 698967004642 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698967004643 E3 interaction surface; other site 698967004644 lipoyl attachment site [posttranslational modification]; other site 698967004645 e3 binding domain; Region: E3_binding; pfam02817 698967004646 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698967004647 lipoate-protein ligase B; Provisional; Region: PRK14345 698967004648 lipoyl synthase; Provisional; Region: PRK05481 698967004649 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698967004650 FeS/SAM binding site; other site 698967004651 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 698967004652 RDD family; Region: RDD; pfam06271 698967004653 glutamine synthetase, type I; Region: GlnA; TIGR00653 698967004654 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698967004655 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698967004656 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 698967004657 MULE transposase domain; Region: MULE; pfam10551 698967004658 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698967004659 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 698967004660 Short repeats of unknown function; Region: ALF; pfam03752 698967004661 Short repeats of unknown function; Region: ALF; pfam03752 698967004662 Short repeats of unknown function; Region: ALF; pfam03752 698967004663 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 698967004664 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 698967004665 LGFP repeat; Region: LGFP; pfam08310 698967004666 LGFP repeat; Region: LGFP; pfam08310 698967004667 LGFP repeat; Region: LGFP; pfam08310 698967004668 AAA domain; Region: AAA_13; pfam13166 698967004669 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 698967004670 Predicted peptidase [General function prediction only]; Region: COG4099 698967004671 CsbD-like; Region: CsbD; pfam05532 698967004672 Predicted permease [General function prediction only]; Region: COG2056 698967004673 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 698967004674 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698967004675 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698967004676 DNA-binding site [nucleotide binding]; DNA binding site 698967004677 FCD domain; Region: FCD; pfam07729 698967004678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967004679 putative substrate translocation pore; other site 698967004680 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 698967004681 nudix motif; other site 698967004682 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 698967004683 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 698967004684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698967004685 catalytic residue [active] 698967004686 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 698967004687 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 698967004688 heme binding pocket [chemical binding]; other site 698967004689 heme ligand [chemical binding]; other site 698967004690 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 698967004691 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698967004692 metal binding triad; other site 698967004693 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698967004694 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698967004695 metal binding triad; other site 698967004696 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698967004697 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 698967004698 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698967004699 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698967004700 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 698967004701 putative active site; other site 698967004702 putative metal binding residues [ion binding]; other site 698967004703 signature motif; other site 698967004704 putative triphosphate binding site [ion binding]; other site 698967004705 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 698967004706 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 698967004707 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698967004708 RNB domain; Region: RNB; pfam00773 698967004709 Predicted membrane protein [General function prediction only]; Region: COG4194 698967004710 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 698967004711 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 698967004712 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 698967004713 RNA/DNA hybrid binding site [nucleotide binding]; other site 698967004714 active site 698967004715 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698967004716 catalytic core [active] 698967004717 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 698967004718 Putative zinc ribbon domain; Region: DUF164; pfam02591 698967004719 Uncharacterized conserved protein [Function unknown]; Region: COG0327 698967004720 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698967004721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 698967004722 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698967004723 hypothetical protein; Provisional; Region: PRK07908 698967004724 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698967004725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698967004726 homodimer interface [polypeptide binding]; other site 698967004727 catalytic residue [active] 698967004728 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 698967004729 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698967004730 motif II; other site 698967004731 Low molecular weight phosphatase family; Region: LMWPc; cd00115 698967004732 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 698967004733 active site 698967004734 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 698967004735 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 698967004736 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 698967004737 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 698967004738 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 698967004739 dimer interface [polypeptide binding]; other site 698967004740 TPP-binding site [chemical binding]; other site 698967004741 Electron transfer DM13; Region: DM13; pfam10517 698967004742 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698967004743 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698967004744 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698967004745 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 698967004746 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698967004747 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698967004748 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698967004749 active site 698967004750 motif I; other site 698967004751 motif II; other site 698967004752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698967004753 motif II; other site 698967004754 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698967004755 Beta-lactamase; Region: Beta-lactamase; pfam00144 698967004756 Predicted membrane protein [Function unknown]; Region: COG2860 698967004757 UPF0126 domain; Region: UPF0126; pfam03458 698967004758 UPF0126 domain; Region: UPF0126; pfam03458 698967004759 DNA primase; Validated; Region: dnaG; PRK05667 698967004760 CHC2 zinc finger; Region: zf-CHC2; pfam01807 698967004761 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 698967004762 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 698967004763 active site 698967004764 metal binding site [ion binding]; metal-binding site 698967004765 interdomain interaction site; other site 698967004766 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 698967004767 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 698967004768 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 698967004769 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 698967004770 glutaminase active site [active] 698967004771 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698967004772 dimer interface [polypeptide binding]; other site 698967004773 active site 698967004774 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 698967004775 dimer interface [polypeptide binding]; other site 698967004776 active site 698967004777 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 698967004778 active site 698967004779 barstar interaction site; other site 698967004780 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 698967004781 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698967004782 Zn2+ binding site [ion binding]; other site 698967004783 Mg2+ binding site [ion binding]; other site 698967004784 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 698967004785 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698967004786 putative active site [active] 698967004787 Repair protein; Region: Repair_PSII; pfam04536 698967004788 glycyl-tRNA synthetase; Provisional; Region: PRK04173 698967004789 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698967004790 motif 1; other site 698967004791 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 698967004792 active site 698967004793 motif 2; other site 698967004794 motif 3; other site 698967004795 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 698967004796 anticodon binding site; other site 698967004797 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698967004798 putative DNA binding site [nucleotide binding]; other site 698967004799 putative Zn2+ binding site [ion binding]; other site 698967004800 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698967004801 metal binding site 2 [ion binding]; metal-binding site 698967004802 putative DNA binding helix; other site 698967004803 metal binding site 1 [ion binding]; metal-binding site 698967004804 dimer interface [polypeptide binding]; other site 698967004805 structural Zn2+ binding site [ion binding]; other site 698967004806 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 698967004807 diiron binding motif [ion binding]; other site 698967004808 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 698967004809 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698967004810 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 698967004811 catalytic residue [active] 698967004812 putative FPP diphosphate binding site; other site 698967004813 putative FPP binding hydrophobic cleft; other site 698967004814 dimer interface [polypeptide binding]; other site 698967004815 putative IPP diphosphate binding site; other site 698967004816 Recombination protein O N terminal; Region: RecO_N; pfam11967 698967004817 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 698967004818 Recombination protein O C terminal; Region: RecO_C; pfam02565 698967004819 GTPase Era; Reviewed; Region: era; PRK00089 698967004820 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 698967004821 G1 box; other site 698967004822 GTP/Mg2+ binding site [chemical binding]; other site 698967004823 Switch I region; other site 698967004824 G2 box; other site 698967004825 Switch II region; other site 698967004826 G3 box; other site 698967004827 G4 box; other site 698967004828 G5 box; other site 698967004829 KH domain; Region: KH_2; pfam07650 698967004830 pyridoxamine kinase; Validated; Region: PRK05756 698967004831 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 698967004832 dimer interface [polypeptide binding]; other site 698967004833 pyridoxal binding site [chemical binding]; other site 698967004834 ATP binding site [chemical binding]; other site 698967004835 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698967004836 Domain of unknown function DUF21; Region: DUF21; pfam01595 698967004837 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698967004838 Transporter associated domain; Region: CorC_HlyC; smart01091 698967004839 metal-binding heat shock protein; Provisional; Region: PRK00016 698967004840 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 698967004841 PhoH-like protein; Region: PhoH; pfam02562 698967004842 RNA methyltransferase, RsmE family; Region: TIGR00046 698967004843 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 698967004844 chaperone protein DnaJ; Provisional; Region: PRK14278 698967004845 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698967004846 HSP70 interaction site [polypeptide binding]; other site 698967004847 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698967004848 Zn binding sites [ion binding]; other site 698967004849 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698967004850 dimer interface [polypeptide binding]; other site 698967004851 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 698967004852 coproporphyrinogen III oxidase; Validated; Region: PRK05628 698967004853 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698967004854 FeS/SAM binding site; other site 698967004855 HemN C-terminal domain; Region: HemN_C; pfam06969 698967004856 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698967004857 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698967004858 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698967004859 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698967004860 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 698967004861 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 698967004862 acyl-activating enzyme (AAE) consensus motif; other site 698967004863 putative AMP binding site [chemical binding]; other site 698967004864 putative active site [active] 698967004865 putative CoA binding site [chemical binding]; other site 698967004866 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 698967004867 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 698967004868 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 698967004869 active site 698967004870 Zn binding site [ion binding]; other site 698967004871 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698967004872 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698967004873 substrate binding pocket [chemical binding]; other site 698967004874 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 698967004875 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 698967004876 active site 698967004877 metal binding site [ion binding]; metal-binding site 698967004878 nudix motif; other site 698967004879 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698967004880 active site 698967004881 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698967004882 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698967004883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967004884 Walker A/P-loop; other site 698967004885 ATP binding site [chemical binding]; other site 698967004886 Q-loop/lid; other site 698967004887 ABC transporter signature motif; other site 698967004888 Walker B; other site 698967004889 D-loop; other site 698967004890 H-loop/switch region; other site 698967004891 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 698967004892 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698967004893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698967004894 homodimer interface [polypeptide binding]; other site 698967004895 catalytic residue [active] 698967004896 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 698967004897 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698967004898 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 698967004899 BCCT family transporter; Region: BCCT; pfam02028 698967004900 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698967004901 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 698967004902 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698967004903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698967004904 dimer interface [polypeptide binding]; other site 698967004905 conserved gate region; other site 698967004906 putative PBP binding loops; other site 698967004907 ABC-ATPase subunit interface; other site 698967004908 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698967004909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698967004910 dimer interface [polypeptide binding]; other site 698967004911 conserved gate region; other site 698967004912 putative PBP binding loops; other site 698967004913 ABC-ATPase subunit interface; other site 698967004914 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698967004915 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698967004916 Walker A/P-loop; other site 698967004917 ATP binding site [chemical binding]; other site 698967004918 Q-loop/lid; other site 698967004919 ABC transporter signature motif; other site 698967004920 Walker B; other site 698967004921 D-loop; other site 698967004922 H-loop/switch region; other site 698967004923 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698967004924 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698967004925 Walker A/P-loop; other site 698967004926 ATP binding site [chemical binding]; other site 698967004927 Q-loop/lid; other site 698967004928 ABC transporter signature motif; other site 698967004929 Walker B; other site 698967004930 D-loop; other site 698967004931 H-loop/switch region; other site 698967004932 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698967004933 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 698967004934 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 698967004935 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698967004936 catalytic residue [active] 698967004937 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698967004938 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698967004939 nucleotide binding site [chemical binding]; other site 698967004940 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 698967004941 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698967004942 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698967004943 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 698967004944 active site residue [active] 698967004945 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 698967004946 putative homodimer interface [polypeptide binding]; other site 698967004947 putative homotetramer interface [polypeptide binding]; other site 698967004948 putative allosteric switch controlling residues; other site 698967004949 putative metal binding site [ion binding]; other site 698967004950 putative homodimer-homodimer interface [polypeptide binding]; other site 698967004951 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 698967004952 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698967004953 TrkA-N domain; Region: TrkA_N; pfam02254 698967004954 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 698967004955 potential frameshift: common BLAST hit: gi|38234323|ref|NP_940090.1| antibiotic ABC transporter 698967004956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967004957 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698967004958 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 698967004959 active site 698967004960 tetramer interface [polypeptide binding]; other site 698967004961 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698967004962 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 698967004963 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698967004964 Mrr N-terminal domain; Region: Mrr_N; pfam14338 698967004965 Restriction endonuclease; Region: Mrr_cat; pfam04471 698967004966 Abi-like protein; Region: Abi_2; pfam07751 698967004967 GTP-binding protein LepA; Provisional; Region: PRK05433 698967004968 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 698967004969 G1 box; other site 698967004970 putative GEF interaction site [polypeptide binding]; other site 698967004971 GTP/Mg2+ binding site [chemical binding]; other site 698967004972 Switch I region; other site 698967004973 G2 box; other site 698967004974 G3 box; other site 698967004975 Switch II region; other site 698967004976 G4 box; other site 698967004977 G5 box; other site 698967004978 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 698967004979 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 698967004980 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 698967004981 PemK-like protein; Region: PemK; pfam02452 698967004982 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 698967004983 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698967004984 hypothetical protein; Validated; Region: PRK05629 698967004985 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 698967004986 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 698967004987 Competence protein; Region: Competence; pfam03772 698967004988 comEA protein; Region: comE; TIGR01259 698967004989 Helix-hairpin-helix motif; Region: HHH; pfam00633 698967004990 helix-hairpin-helix signature motif; other site 698967004991 EDD domain protein, DegV family; Region: DegV; TIGR00762 698967004992 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 698967004993 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698967004994 catalytic core [active] 698967004995 Oligomerisation domain; Region: Oligomerisation; cl00519 698967004996 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 698967004997 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 698967004998 active site 698967004999 (T/H)XGH motif; other site 698967005000 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 698967005001 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 698967005002 putative catalytic cysteine [active] 698967005003 gamma-glutamyl kinase; Provisional; Region: PRK05429 698967005004 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 698967005005 nucleotide binding site [chemical binding]; other site 698967005006 homotetrameric interface [polypeptide binding]; other site 698967005007 putative phosphate binding site [ion binding]; other site 698967005008 putative allosteric binding site; other site 698967005009 PUA domain; Region: PUA; pfam01472 698967005010 GTPase CgtA; Reviewed; Region: obgE; PRK12296 698967005011 GTP1/OBG; Region: GTP1_OBG; pfam01018 698967005012 Obg GTPase; Region: Obg; cd01898 698967005013 G1 box; other site 698967005014 GTP/Mg2+ binding site [chemical binding]; other site 698967005015 Switch I region; other site 698967005016 G2 box; other site 698967005017 G3 box; other site 698967005018 Switch II region; other site 698967005019 G4 box; other site 698967005020 G5 box; other site 698967005021 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 698967005022 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 698967005023 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 698967005024 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 698967005025 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698967005026 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 698967005027 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 698967005028 homodimer interface [polypeptide binding]; other site 698967005029 oligonucleotide binding site [chemical binding]; other site 698967005030 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 698967005031 active site 698967005032 multimer interface [polypeptide binding]; other site 698967005033 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 698967005034 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 698967005035 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698967005036 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698967005037 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 698967005038 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698967005039 active site 698967005040 HIGH motif; other site 698967005041 nucleotide binding site [chemical binding]; other site 698967005042 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698967005043 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 698967005044 active site 698967005045 KMSKS motif; other site 698967005046 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 698967005047 tRNA binding surface [nucleotide binding]; other site 698967005048 anticodon binding site; other site 698967005049 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 698967005050 malate dehydrogenase; Provisional; Region: PRK05442 698967005051 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 698967005052 NAD(P) binding site [chemical binding]; other site 698967005053 dimer interface [polypeptide binding]; other site 698967005054 malate binding site [chemical binding]; other site 698967005055 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698967005056 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698967005057 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 698967005058 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 698967005059 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 698967005060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698967005061 Walker A motif; other site 698967005062 ATP binding site [chemical binding]; other site 698967005063 Walker B motif; other site 698967005064 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 698967005065 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698967005066 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698967005067 glutamine binding [chemical binding]; other site 698967005068 catalytic triad [active] 698967005069 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 698967005070 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698967005071 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 698967005072 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 698967005073 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698967005074 oligomer interface [polypeptide binding]; other site 698967005075 active site residues [active] 698967005076 Clp protease; Region: CLP_protease; pfam00574 698967005077 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698967005078 oligomer interface [polypeptide binding]; other site 698967005079 active site residues [active] 698967005080 trigger factor; Provisional; Region: tig; PRK01490 698967005081 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698967005082 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 698967005083 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 698967005084 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698967005085 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698967005086 catalytic residues [active] 698967005087 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 698967005088 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 698967005089 Zn binding site [ion binding]; other site 698967005090 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698967005091 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698967005092 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 698967005093 apolar tunnel; other site 698967005094 heme binding site [chemical binding]; other site 698967005095 dimerization interface [polypeptide binding]; other site 698967005096 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698967005097 active site 698967005098 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 698967005099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967005100 Walker A/P-loop; other site 698967005101 ATP binding site [chemical binding]; other site 698967005102 Q-loop/lid; other site 698967005103 ABC transporter signature motif; other site 698967005104 Walker B; other site 698967005105 D-loop; other site 698967005106 H-loop/switch region; other site 698967005107 ABC transporter; Region: ABC_tran_2; pfam12848 698967005108 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698967005109 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698967005110 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698967005111 dimer interface [polypeptide binding]; other site 698967005112 ssDNA binding site [nucleotide binding]; other site 698967005113 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698967005114 Copper resistance protein D; Region: CopD; pfam05425 698967005115 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 698967005116 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 698967005117 Carbon starvation protein CstA; Region: CstA; pfam02554 698967005118 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 698967005119 Protein of unknown function (DUF466); Region: DUF466; pfam04328 698967005120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967005121 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698967005122 putative substrate translocation pore; other site 698967005123 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 698967005124 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 698967005125 NADP binding site [chemical binding]; other site 698967005126 dimer interface [polypeptide binding]; other site 698967005127 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698967005128 classical (c) SDRs; Region: SDR_c; cd05233 698967005129 NAD(P) binding site [chemical binding]; other site 698967005130 active site 698967005131 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 698967005132 catalytic site [active] 698967005133 putative active site [active] 698967005134 putative substrate binding site [chemical binding]; other site 698967005135 dimer interface [polypeptide binding]; other site 698967005136 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698967005137 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698967005138 inhibitor site; inhibition site 698967005139 active site 698967005140 dimer interface [polypeptide binding]; other site 698967005141 catalytic residue [active] 698967005142 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 698967005143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698967005144 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 698967005145 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698967005146 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 698967005147 conserved cis-peptide bond; other site 698967005148 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 698967005149 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 698967005150 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698967005151 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 698967005152 catalytic triad [active] 698967005153 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698967005154 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698967005155 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 698967005156 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698967005157 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 698967005158 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698967005159 phosphate binding site [ion binding]; other site 698967005160 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 698967005161 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 698967005162 active site 2 [active] 698967005163 active site 1 [active] 698967005164 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 698967005165 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698967005166 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 698967005167 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 698967005168 putative NAD(P) binding site [chemical binding]; other site 698967005169 active site 698967005170 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 698967005171 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 698967005172 active site 698967005173 Glucitol operon activator protein (GutM); Region: GutM; cl01890 698967005174 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 698967005175 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 698967005176 active site 698967005177 dimerization interface [polypeptide binding]; other site 698967005178 ribonuclease PH; Reviewed; Region: rph; PRK00173 698967005179 Ribonuclease PH; Region: RNase_PH_bact; cd11362 698967005180 hexamer interface [polypeptide binding]; other site 698967005181 active site 698967005182 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 698967005183 glutamate racemase; Provisional; Region: PRK00865 698967005184 Rhomboid family; Region: Rhomboid; pfam01694 698967005185 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 698967005186 putative active site pocket [active] 698967005187 cleavage site 698967005188 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 698967005189 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 698967005190 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 698967005191 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 698967005192 active site 698967005193 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 698967005194 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698967005195 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698967005196 putative Mg++ binding site [ion binding]; other site 698967005197 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 698967005198 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698967005199 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698967005200 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698967005201 active site 698967005202 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 698967005203 dimer interface [polypeptide binding]; other site 698967005204 putative active site [active] 698967005205 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 698967005206 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 698967005207 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 698967005208 phosphoserine phosphatase SerB; Region: serB; TIGR00338 698967005209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698967005210 motif II; other site 698967005211 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 698967005212 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 698967005213 D-pathway; other site 698967005214 Putative ubiquinol binding site [chemical binding]; other site 698967005215 Low-spin heme (heme b) binding site [chemical binding]; other site 698967005216 Putative water exit pathway; other site 698967005217 Binuclear center (heme o3/CuB) [ion binding]; other site 698967005218 K-pathway; other site 698967005219 Putative proton exit pathway; other site 698967005220 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698967005221 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698967005222 dimer interface [polypeptide binding]; other site 698967005223 putative radical transfer pathway; other site 698967005224 diiron center [ion binding]; other site 698967005225 tyrosyl radical; other site 698967005226 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 698967005227 Ferritin-like domain; Region: Ferritin; pfam00210 698967005228 ferroxidase diiron center [ion binding]; other site 698967005229 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 698967005230 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 698967005231 Class I ribonucleotide reductase; Region: RNR_I; cd01679 698967005232 active site 698967005233 dimer interface [polypeptide binding]; other site 698967005234 catalytic residues [active] 698967005235 effector binding site; other site 698967005236 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698967005237 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698967005238 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698967005239 catalytic residues [active] 698967005240 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 698967005241 active site lid residues [active] 698967005242 substrate binding pocket [chemical binding]; other site 698967005243 catalytic residues [active] 698967005244 substrate-Mg2+ binding site; other site 698967005245 aspartate-rich region 1; other site 698967005246 aspartate-rich region 2; other site 698967005247 phytoene desaturase; Region: crtI_fam; TIGR02734 698967005248 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698967005249 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 698967005250 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 698967005251 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 698967005252 homodimer interface [polypeptide binding]; other site 698967005253 NAD binding pocket [chemical binding]; other site 698967005254 ATP binding pocket [chemical binding]; other site 698967005255 Mg binding site [ion binding]; other site 698967005256 active-site loop [active] 698967005257 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 698967005258 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 698967005259 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 698967005260 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 698967005261 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 698967005262 Predicted transcriptional regulator [Transcription]; Region: COG2345 698967005263 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 698967005264 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698967005265 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 698967005266 catalytic residues [active] 698967005267 Methylamine utilisation protein MauE; Region: MauE; pfam07291 698967005268 phosphoglucomutase; Validated; Region: PRK07564 698967005269 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 698967005270 active site 698967005271 substrate binding site [chemical binding]; other site 698967005272 metal binding site [ion binding]; metal-binding site 698967005273 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698967005274 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698967005275 FtsX-like permease family; Region: FtsX; pfam02687 698967005276 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698967005277 FtsX-like permease family; Region: FtsX; pfam02687 698967005278 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698967005279 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698967005280 Walker A/P-loop; other site 698967005281 ATP binding site [chemical binding]; other site 698967005282 Q-loop/lid; other site 698967005283 ABC transporter signature motif; other site 698967005284 Walker B; other site 698967005285 D-loop; other site 698967005286 H-loop/switch region; other site 698967005287 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698967005288 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698967005289 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698967005290 hinge; other site 698967005291 active site 698967005292 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 698967005293 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 698967005294 GAF domain; Region: GAF_2; pfam13185 698967005295 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698967005296 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698967005297 DNA binding residues [nucleotide binding] 698967005298 dimerization interface [polypeptide binding]; other site 698967005299 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698967005300 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698967005301 dimer interface [polypeptide binding]; other site 698967005302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698967005303 catalytic residue [active] 698967005304 serine O-acetyltransferase; Region: cysE; TIGR01172 698967005305 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 698967005306 trimer interface [polypeptide binding]; other site 698967005307 active site 698967005308 substrate binding site [chemical binding]; other site 698967005309 CoA binding site [chemical binding]; other site 698967005310 Predicted acetyltransferase [General function prediction only]; Region: COG2388 698967005311 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 698967005312 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 698967005313 putative active site [active] 698967005314 metal binding site [ion binding]; metal-binding site 698967005315 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 698967005316 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698967005317 Walker A/P-loop; other site 698967005318 ATP binding site [chemical binding]; other site 698967005319 Q-loop/lid; other site 698967005320 ABC transporter signature motif; other site 698967005321 Walker B; other site 698967005322 D-loop; other site 698967005323 H-loop/switch region; other site 698967005324 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 698967005325 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698967005326 intersubunit interface [polypeptide binding]; other site 698967005327 ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism]; Region: FepD; COG0609 698967005328 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698967005329 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698967005330 ABC-ATPase subunit interface; other site 698967005331 dimer interface [polypeptide binding]; other site 698967005332 putative PBP binding regions; other site 698967005333 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698967005334 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 698967005335 DNA methylase; Region: N6_N4_Mtase; pfam01555 698967005336 DNA methylase; Region: N6_N4_Mtase; pfam01555 698967005337 HTH-like domain; Region: HTH_21; pfam13276 698967005338 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 698967005339 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 698967005340 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698967005341 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698967005342 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 698967005343 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967005344 Walker A/P-loop; other site 698967005345 ATP binding site [chemical binding]; other site 698967005346 Q-loop/lid; other site 698967005347 ABC transporter signature motif; other site 698967005348 Walker B; other site 698967005349 D-loop; other site 698967005350 H-loop/switch region; other site 698967005351 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 698967005352 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967005353 Walker A/P-loop; other site 698967005354 ATP binding site [chemical binding]; other site 698967005355 Q-loop/lid; other site 698967005356 ABC transporter signature motif; other site 698967005357 Walker B; other site 698967005358 D-loop; other site 698967005359 H-loop/switch region; other site 698967005360 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 698967005361 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 698967005362 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 698967005363 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 698967005364 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 698967005365 FMN binding site [chemical binding]; other site 698967005366 active site 698967005367 catalytic residues [active] 698967005368 substrate binding site [chemical binding]; other site 698967005369 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 698967005370 PhoU domain; Region: PhoU; pfam01895 698967005371 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 698967005372 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 698967005373 Walker A/P-loop; other site 698967005374 ATP binding site [chemical binding]; other site 698967005375 Q-loop/lid; other site 698967005376 ABC transporter signature motif; other site 698967005377 Walker B; other site 698967005378 D-loop; other site 698967005379 H-loop/switch region; other site 698967005380 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 698967005381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698967005382 dimer interface [polypeptide binding]; other site 698967005383 conserved gate region; other site 698967005384 putative PBP binding loops; other site 698967005385 ABC-ATPase subunit interface; other site 698967005386 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 698967005387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698967005388 dimer interface [polypeptide binding]; other site 698967005389 conserved gate region; other site 698967005390 putative PBP binding loops; other site 698967005391 ABC-ATPase subunit interface; other site 698967005392 PBP superfamily domain; Region: PBP_like_2; cl17296 698967005393 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 698967005394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698967005395 Coenzyme A binding pocket [chemical binding]; other site 698967005396 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698967005397 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698967005398 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 698967005399 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 698967005400 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 698967005401 heme-binding site [chemical binding]; other site 698967005402 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 698967005403 substrate binding site [chemical binding]; other site 698967005404 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 698967005405 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 698967005406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698967005407 catalytic residue [active] 698967005408 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 698967005409 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 698967005410 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698967005411 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 698967005412 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 698967005413 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 698967005414 dimerization interface [polypeptide binding]; other site 698967005415 putative ATP binding site [chemical binding]; other site 698967005416 amidophosphoribosyltransferase; Provisional; Region: PRK07847 698967005417 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 698967005418 active site 698967005419 tetramer interface [polypeptide binding]; other site 698967005420 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698967005421 active site 698967005422 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 698967005423 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 698967005424 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698967005425 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698967005426 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698967005427 dimer interface [polypeptide binding]; other site 698967005428 putative radical transfer pathway; other site 698967005429 diiron center [ion binding]; other site 698967005430 tyrosyl radical; other site 698967005431 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 698967005432 catalytic residues [active] 698967005433 dimer interface [polypeptide binding]; other site 698967005434 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 698967005435 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698967005436 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 698967005437 ATP binding site [chemical binding]; other site 698967005438 active site 698967005439 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 698967005440 substrate binding site [chemical binding]; other site 698967005441 adenylosuccinate lyase; Region: purB; TIGR00928 698967005442 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 698967005443 tetramer interface [polypeptide binding]; other site 698967005444 potential frameshift: common BLAST hit: gi|38234496|ref|NP_940263.1| aspartate aminotransferase 698967005445 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698967005446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698967005447 homodimer interface [polypeptide binding]; other site 698967005448 catalytic residue [active] 698967005449 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698967005450 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 698967005451 TrkA-N domain; Region: TrkA_N; pfam02254 698967005452 TrkA-C domain; Region: TrkA_C; pfam02080 698967005453 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 698967005454 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 698967005455 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 698967005456 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 698967005457 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 698967005458 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 698967005459 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 698967005460 nucleotide binding site/active site [active] 698967005461 HIT family signature motif; other site 698967005462 catalytic residue [active] 698967005463 PGAP1-like protein; Region: PGAP1; pfam07819 698967005464 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698967005465 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698967005466 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698967005467 dimerization interface [polypeptide binding]; other site 698967005468 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698967005469 dimer interface [polypeptide binding]; other site 698967005470 phosphorylation site [posttranslational modification] 698967005471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698967005472 ATP binding site [chemical binding]; other site 698967005473 Mg2+ binding site [ion binding]; other site 698967005474 G-X-G motif; other site 698967005475 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698967005476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698967005477 active site 698967005478 phosphorylation site [posttranslational modification] 698967005479 intermolecular recognition site; other site 698967005480 dimerization interface [polypeptide binding]; other site 698967005481 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698967005482 DNA binding site [nucleotide binding] 698967005483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967005484 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698967005485 putative substrate translocation pore; other site 698967005486 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698967005487 xanthine permease; Region: pbuX; TIGR03173 698967005488 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 698967005489 pyruvate dehydrogenase; Provisional; Region: PRK06546 698967005490 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 698967005491 PYR/PP interface [polypeptide binding]; other site 698967005492 dimer interface [polypeptide binding]; other site 698967005493 tetramer interface [polypeptide binding]; other site 698967005494 TPP binding site [chemical binding]; other site 698967005495 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698967005496 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 698967005497 TPP-binding site [chemical binding]; other site 698967005498 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698967005499 Uncharacterized conserved protein [Function unknown]; Region: COG3610 698967005500 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698967005501 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698967005502 Uncharacterized conserved protein [Function unknown]; Region: COG3610 698967005503 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 698967005504 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 698967005505 active site 698967005506 homotetramer interface [polypeptide binding]; other site 698967005507 META domain; Region: META; cl01245 698967005508 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 698967005509 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 698967005510 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698967005511 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698967005512 DNA binding site [nucleotide binding] 698967005513 domain linker motif; other site 698967005514 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 698967005515 putative dimerization interface [polypeptide binding]; other site 698967005516 putative ligand binding site [chemical binding]; other site 698967005517 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698967005518 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 698967005519 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698967005520 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 698967005521 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698967005522 active site 698967005523 HIGH motif; other site 698967005524 nucleotide binding site [chemical binding]; other site 698967005525 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698967005526 KMSKS motif; other site 698967005527 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698967005528 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 698967005529 homotrimer interaction site [polypeptide binding]; other site 698967005530 zinc binding site [ion binding]; other site 698967005531 CDP-binding sites; other site 698967005532 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 698967005533 substrate binding site; other site 698967005534 dimer interface; other site 698967005535 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 698967005536 DNA repair protein RadA; Provisional; Region: PRK11823 698967005537 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698967005538 Walker A motif; other site 698967005539 ATP binding site [chemical binding]; other site 698967005540 Walker B motif; other site 698967005541 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698967005542 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 698967005543 active site clefts [active] 698967005544 zinc binding site [ion binding]; other site 698967005545 dimer interface [polypeptide binding]; other site 698967005546 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698967005547 endonuclease III; Region: ENDO3c; smart00478 698967005548 minor groove reading motif; other site 698967005549 helix-hairpin-helix signature motif; other site 698967005550 substrate binding pocket [chemical binding]; other site 698967005551 active site 698967005552 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698967005553 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698967005554 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 698967005555 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 698967005556 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 698967005557 Clp amino terminal domain; Region: Clp_N; pfam02861 698967005558 Clp amino terminal domain; Region: Clp_N; pfam02861 698967005559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698967005560 Walker A motif; other site 698967005561 ATP binding site [chemical binding]; other site 698967005562 Walker B motif; other site 698967005563 arginine finger; other site 698967005564 UvrB/uvrC motif; Region: UVR; pfam02151 698967005565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698967005566 Walker A motif; other site 698967005567 ATP binding site [chemical binding]; other site 698967005568 Walker B motif; other site 698967005569 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698967005570 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 698967005571 oligomer interface [polypeptide binding]; other site 698967005572 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698967005573 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698967005574 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 698967005575 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698967005576 dimer interface [polypeptide binding]; other site 698967005577 putative anticodon binding site; other site 698967005578 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698967005579 motif 1; other site 698967005580 dimer interface [polypeptide binding]; other site 698967005581 active site 698967005582 motif 2; other site 698967005583 motif 3; other site 698967005584 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698967005585 YcaO-like family; Region: YcaO; pfam02624 698967005586 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698967005587 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698967005588 Walker A/P-loop; other site 698967005589 ATP binding site [chemical binding]; other site 698967005590 Q-loop/lid; other site 698967005591 ABC transporter signature motif; other site 698967005592 Walker B; other site 698967005593 D-loop; other site 698967005594 H-loop/switch region; other site 698967005595 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698967005596 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 698967005597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 698967005598 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698967005599 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698967005600 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698967005601 active site 698967005602 KMSKS motif; other site 698967005603 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 698967005604 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 698967005605 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 698967005606 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 698967005607 catalytic center binding site [active] 698967005608 ATP binding site [chemical binding]; other site 698967005609 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 698967005610 homooctamer interface [polypeptide binding]; other site 698967005611 active site 698967005612 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698967005613 dihydropteroate synthase; Region: DHPS; TIGR01496 698967005614 substrate binding pocket [chemical binding]; other site 698967005615 dimer interface [polypeptide binding]; other site 698967005616 inhibitor binding site; inhibition site 698967005617 Protein of unknown function, DUF393; Region: DUF393; pfam04134 698967005618 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 698967005619 homodecamer interface [polypeptide binding]; other site 698967005620 GTP cyclohydrolase I; Provisional; Region: PLN03044 698967005621 active site 698967005622 putative catalytic site residues [active] 698967005623 zinc binding site [ion binding]; other site 698967005624 GTP-CH-I/GFRP interaction surface; other site 698967005625 FtsH Extracellular; Region: FtsH_ext; pfam06480 698967005626 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 698967005627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698967005628 Walker A motif; other site 698967005629 ATP binding site [chemical binding]; other site 698967005630 Walker B motif; other site 698967005631 arginine finger; other site 698967005632 Peptidase family M41; Region: Peptidase_M41; pfam01434 698967005633 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698967005634 active site 698967005635 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 698967005636 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 698967005637 Ligand Binding Site [chemical binding]; other site 698967005638 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 698967005639 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 698967005640 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 698967005641 dimer interface [polypeptide binding]; other site 698967005642 substrate binding site [chemical binding]; other site 698967005643 metal binding sites [ion binding]; metal-binding site 698967005644 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698967005645 active site residue [active] 698967005646 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698967005647 MarR family; Region: MarR_2; pfam12802 698967005648 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698967005649 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 698967005650 acyl-activating enzyme (AAE) consensus motif; other site 698967005651 AMP binding site [chemical binding]; other site 698967005652 active site 698967005653 CoA binding site [chemical binding]; other site 698967005654 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698967005655 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 698967005656 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698967005657 putative trimer interface [polypeptide binding]; other site 698967005658 putative CoA binding site [chemical binding]; other site 698967005659 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698967005660 putative trimer interface [polypeptide binding]; other site 698967005661 putative CoA binding site [chemical binding]; other site 698967005662 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698967005663 metal ion-dependent adhesion site (MIDAS); other site 698967005664 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698967005665 active site 698967005666 catalytic site [active] 698967005667 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698967005668 Secretory lipase; Region: LIP; pfam03583 698967005669 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698967005670 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 698967005671 Helix-turn-helix domain; Region: HTH_28; pfam13518 698967005672 putative transposase OrfB; Reviewed; Region: PHA02517 698967005673 HTH-like domain; Region: HTH_21; pfam13276 698967005674 Integrase core domain; Region: rve; pfam00665 698967005675 Integrase core domain; Region: rve_2; pfam13333 698967005676 putative transposase OrfB; Reviewed; Region: PHA02517 698967005677 HTH-like domain; Region: HTH_21; pfam13276 698967005678 Integrase core domain; Region: rve; pfam00665 698967005679 Integrase core domain; Region: rve_2; pfam13333 698967005680 Homeodomain-like domain; Region: HTH_23; cl17451 698967005681 Helix-turn-helix domain; Region: HTH_28; pfam13518 698967005682 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698967005683 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698967005684 ring oligomerisation interface [polypeptide binding]; other site 698967005685 ATP/Mg binding site [chemical binding]; other site 698967005686 stacking interactions; other site 698967005687 hinge regions; other site 698967005688 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698967005689 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698967005690 MULE transposase domain; Region: MULE; pfam10551 698967005691 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698967005692 Integrase core domain; Region: rve; pfam00665 698967005693 MULE transposase domain; Region: MULE; pfam10551 698967005694 hypothetical protein; Provisional; Region: PRK07907 698967005695 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 698967005696 active site 698967005697 metal binding site [ion binding]; metal-binding site 698967005698 dimer interface [polypeptide binding]; other site 698967005699 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698967005700 carboxylate-amine ligase; Provisional; Region: PRK13517 698967005701 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 698967005702 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698967005703 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698967005704 active site 698967005705 catalytic residues [active] 698967005706 metal binding site [ion binding]; metal-binding site 698967005707 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698967005708 Coenzyme A binding pocket [chemical binding]; other site 698967005709 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698967005710 putative catalytic site [active] 698967005711 putative metal binding site [ion binding]; other site 698967005712 putative phosphate binding site [ion binding]; other site 698967005713 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 698967005714 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 698967005715 putative active site [active] 698967005716 catalytic site [active] 698967005717 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 698967005718 putative active site [active] 698967005719 catalytic site [active] 698967005720 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698967005721 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698967005722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967005723 Walker A/P-loop; other site 698967005724 ATP binding site [chemical binding]; other site 698967005725 Q-loop/lid; other site 698967005726 ABC transporter signature motif; other site 698967005727 Walker B; other site 698967005728 D-loop; other site 698967005729 H-loop/switch region; other site 698967005730 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 698967005731 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698967005732 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698967005733 substrate binding pocket [chemical binding]; other site 698967005734 membrane-bound complex binding site; other site 698967005735 hinge residues; other site 698967005736 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698967005737 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698967005738 active site 698967005739 ATP binding site [chemical binding]; other site 698967005740 substrate binding site [chemical binding]; other site 698967005741 activation loop (A-loop); other site 698967005742 propionate/acetate kinase; Provisional; Region: PRK12379 698967005743 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 698967005744 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 698967005745 ferredoxin-NADP+ reductase; Region: PLN02852 698967005746 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698967005747 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698967005748 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 698967005749 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698967005750 active site 698967005751 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698967005752 putative active site [active] 698967005753 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 698967005754 Cna protein B-type domain; Region: Cna_B; pfam05738 698967005755 Cna protein B-type domain; Region: Cna_B; pfam05738 698967005756 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 698967005757 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 698967005758 GDP-binding site [chemical binding]; other site 698967005759 ACT binding site; other site 698967005760 IMP binding site; other site 698967005761 conserved repeat domain; Region: B_ant_repeat; TIGR01451 698967005762 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 698967005763 Predicted membrane protein [Function unknown]; Region: COG4129 698967005764 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698967005765 chromosome segregation protein; Provisional; Region: PRK03918 698967005766 Predicted membrane protein [Function unknown]; Region: COG4129 698967005767 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698967005768 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 698967005769 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698967005770 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 698967005771 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698967005772 Transposase; Region: HTH_Tnp_1; pfam01527 698967005773 HTH-like domain; Region: HTH_21; pfam13276 698967005774 Integrase core domain; Region: rve; pfam00665 698967005775 putative transporter; Provisional; Region: PRK09821 698967005776 GntP family permease; Region: GntP_permease; pfam02447 698967005777 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698967005778 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698967005779 NAD(P) binding site [chemical binding]; other site 698967005780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 698967005781 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698967005782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698967005783 DNA-binding site [nucleotide binding]; DNA binding site 698967005784 FCD domain; Region: FCD; pfam07729 698967005785 Cna protein B-type domain; Region: Cna_B; pfam05738 698967005786 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 698967005787 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698967005788 MULE transposase domain; Region: MULE; pfam10551 698967005789 TQXA domain; Region: TQXA_dom; TIGR03934 698967005790 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 698967005791 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 698967005792 active site 698967005793 intersubunit interface [polypeptide binding]; other site 698967005794 zinc binding site [ion binding]; other site 698967005795 Na+ binding site [ion binding]; other site 698967005796 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 698967005797 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698967005798 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698967005799 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698967005800 active site 698967005801 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698967005802 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698967005803 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698967005804 active site residue [active] 698967005805 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698967005806 active site residue [active] 698967005807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698967005808 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 698967005809 Clp amino terminal domain; Region: Clp_N; pfam02861 698967005810 Clp amino terminal domain; Region: Clp_N; pfam02861 698967005811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698967005812 Walker A motif; other site 698967005813 ATP binding site [chemical binding]; other site 698967005814 Walker B motif; other site 698967005815 arginine finger; other site 698967005816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698967005817 Walker A motif; other site 698967005818 ATP binding site [chemical binding]; other site 698967005819 Walker B motif; other site 698967005820 arginine finger; other site 698967005821 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698967005822 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698967005823 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 698967005824 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698967005825 Walker A/P-loop; other site 698967005826 ATP binding site [chemical binding]; other site 698967005827 Q-loop/lid; other site 698967005828 ABC transporter signature motif; other site 698967005829 Walker B; other site 698967005830 D-loop; other site 698967005831 H-loop/switch region; other site 698967005832 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698967005833 EamA-like transporter family; Region: EamA; pfam00892 698967005834 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698967005835 EamA-like transporter family; Region: EamA; pfam00892 698967005836 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 698967005837 FAD binding pocket [chemical binding]; other site 698967005838 FAD binding motif [chemical binding]; other site 698967005839 phosphate binding motif [ion binding]; other site 698967005840 beta-alpha-beta structure motif; other site 698967005841 NAD binding pocket [chemical binding]; other site 698967005842 Predicted amidohydrolase [General function prediction only]; Region: COG0388 698967005843 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 698967005844 putative active site [active] 698967005845 catalytic triad [active] 698967005846 putative dimer interface [polypeptide binding]; other site 698967005847 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 698967005848 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 698967005849 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 698967005850 NAD binding site [chemical binding]; other site 698967005851 substrate binding site [chemical binding]; other site 698967005852 catalytic Zn binding site [ion binding]; other site 698967005853 tetramer interface [polypeptide binding]; other site 698967005854 structural Zn binding site [ion binding]; other site 698967005855 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698967005856 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698967005857 NAD(P) binding site [chemical binding]; other site 698967005858 catalytic residues [active] 698967005859 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 698967005860 DNA binding residues [nucleotide binding] 698967005861 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698967005862 putative dimer interface [polypeptide binding]; other site 698967005863 chaperone protein DnaJ; Provisional; Region: PRK14279 698967005864 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698967005865 HSP70 interaction site [polypeptide binding]; other site 698967005866 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698967005867 Zn binding sites [ion binding]; other site 698967005868 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698967005869 dimer interface [polypeptide binding]; other site 698967005870 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 698967005871 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 698967005872 dimer interface [polypeptide binding]; other site 698967005873 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 698967005874 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 698967005875 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 698967005876 nucleotide binding site [chemical binding]; other site 698967005877 NEF interaction site [polypeptide binding]; other site 698967005878 SBD interface [polypeptide binding]; other site 698967005879 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698967005880 PAS domain; Region: PAS_9; pfam13426 698967005881 putative active site [active] 698967005882 heme pocket [chemical binding]; other site 698967005883 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698967005884 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698967005885 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698967005886 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698967005887 Walker A/P-loop; other site 698967005888 ATP binding site [chemical binding]; other site 698967005889 Q-loop/lid; other site 698967005890 ABC transporter signature motif; other site 698967005891 Walker B; other site 698967005892 D-loop; other site 698967005893 H-loop/switch region; other site 698967005894 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698967005895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698967005896 dimer interface [polypeptide binding]; other site 698967005897 conserved gate region; other site 698967005898 putative PBP binding loops; other site 698967005899 ABC-ATPase subunit interface; other site 698967005900 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698967005901 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 698967005902 Walker A/P-loop; other site 698967005903 ATP binding site [chemical binding]; other site 698967005904 Q-loop/lid; other site 698967005905 ABC transporter signature motif; other site 698967005906 Walker B; other site 698967005907 D-loop; other site 698967005908 H-loop/switch region; other site 698967005909 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698967005910 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698967005911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698967005912 dimer interface [polypeptide binding]; other site 698967005913 conserved gate region; other site 698967005914 putative PBP binding loops; other site 698967005915 ABC-ATPase subunit interface; other site 698967005916 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698967005917 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 698967005918 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698967005919 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698967005920 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 698967005921 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 698967005922 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 698967005923 dimerization interface [polypeptide binding]; other site 698967005924 ATP binding site [chemical binding]; other site 698967005925 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 698967005926 dimerization interface [polypeptide binding]; other site 698967005927 ATP binding site [chemical binding]; other site 698967005928 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 698967005929 putative active site [active] 698967005930 catalytic triad [active] 698967005931 potential frameshift: common BLAST hit: gi|32479398|ref|NP_862251.1| Tnp1250a 698967005932 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698967005933 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698967005934 Integrase core domain; Region: rve; pfam00665 698967005935 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 698967005936 FAD binding pocket [chemical binding]; other site 698967005937 FAD binding motif [chemical binding]; other site 698967005938 phosphate binding motif [ion binding]; other site 698967005939 NAD binding pocket [chemical binding]; other site 698967005940 Siderophore-interacting protein; Region: SIP; pfam04954 698967005941 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698967005942 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698967005943 Walker A/P-loop; other site 698967005944 ATP binding site [chemical binding]; other site 698967005945 Q-loop/lid; other site 698967005946 ABC transporter signature motif; other site 698967005947 Walker B; other site 698967005948 D-loop; other site 698967005949 H-loop/switch region; other site 698967005950 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698967005951 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698967005952 ABC-ATPase subunit interface; other site 698967005953 dimer interface [polypeptide binding]; other site 698967005954 putative PBP binding regions; other site 698967005955 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698967005956 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698967005957 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698967005958 ABC-ATPase subunit interface; other site 698967005959 dimer interface [polypeptide binding]; other site 698967005960 putative PBP binding regions; other site 698967005961 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 698967005962 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698967005963 siderophore binding site; other site 698967005964 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 698967005965 ferredoxin-NADP+ reductase; Region: PLN02852 698967005966 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698967005967 4Fe-4S binding domain; Region: Fer4; cl02805 698967005968 Cysteine-rich domain; Region: CCG; pfam02754 698967005969 Cysteine-rich domain; Region: CCG; pfam02754 698967005970 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 698967005971 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698967005972 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 698967005973 putative NAD(P) binding site [chemical binding]; other site 698967005974 catalytic Zn binding site [ion binding]; other site 698967005975 aminotransferase AlaT; Validated; Region: PRK09265 698967005976 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698967005977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698967005978 homodimer interface [polypeptide binding]; other site 698967005979 catalytic residue [active] 698967005980 YibE/F-like protein; Region: YibE_F; pfam07907 698967005981 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 698967005982 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 698967005983 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698967005984 dimer interface [polypeptide binding]; other site 698967005985 putative anticodon binding site; other site 698967005986 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698967005987 motif 1; other site 698967005988 dimer interface [polypeptide binding]; other site 698967005989 active site 698967005990 motif 2; other site 698967005991 motif 3; other site 698967005992 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698967005993 Protein of unknown function (DUF998); Region: DUF998; pfam06197 698967005994 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 698967005995 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 698967005996 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 698967005997 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698967005998 trimer interface [polypeptide binding]; other site 698967005999 active site 698967006000 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698967006001 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967006002 Walker A/P-loop; other site 698967006003 ATP binding site [chemical binding]; other site 698967006004 Q-loop/lid; other site 698967006005 ABC transporter signature motif; other site 698967006006 Walker B; other site 698967006007 D-loop; other site 698967006008 H-loop/switch region; other site 698967006009 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698967006010 MULE transposase domain; Region: MULE; pfam10551 698967006011 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 698967006012 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698967006013 active site 698967006014 BRO family, N-terminal domain; Region: Bro-N; smart01040 698967006015 Abi-like protein; Region: Abi_2; cl01988 698967006016 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 698967006017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967006018 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 698967006019 Walker A/P-loop; other site 698967006020 ATP binding site [chemical binding]; other site 698967006021 Q-loop/lid; other site 698967006022 ABC transporter signature motif; other site 698967006023 Walker B; other site 698967006024 D-loop; other site 698967006025 H-loop/switch region; other site 698967006026 metabolite-proton symporter; Region: 2A0106; TIGR00883 698967006027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967006028 putative substrate translocation pore; other site 698967006029 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698967006030 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698967006031 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 698967006032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967006033 putative substrate translocation pore; other site 698967006034 YwiC-like protein; Region: YwiC; pfam14256 698967006035 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698967006036 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698967006037 VanW like protein; Region: VanW; pfam04294 698967006038 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 698967006039 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 698967006040 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 698967006041 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 698967006042 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698967006043 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698967006044 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698967006045 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698967006046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698967006047 S-adenosylmethionine binding site [chemical binding]; other site 698967006048 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 698967006049 active site 698967006050 substrate-binding site [chemical binding]; other site 698967006051 metal-binding site [ion binding] 698967006052 GTP binding site [chemical binding]; other site 698967006053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698967006054 S-adenosylmethionine binding site [chemical binding]; other site 698967006055 LabA_like proteins; Region: LabA_like; cd06167 698967006056 putative metal binding site [ion binding]; other site 698967006057 MMPL family; Region: MMPL; pfam03176 698967006058 MMPL family; Region: MMPL; pfam03176 698967006059 Predicted integral membrane protein [Function unknown]; Region: COG0392 698967006060 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 698967006061 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 698967006062 TQXA domain; Region: TQXA_dom; TIGR03934 698967006063 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 698967006064 active site 698967006065 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698967006066 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698967006067 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698967006068 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698967006069 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 698967006070 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 698967006071 active site 698967006072 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 698967006073 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698967006074 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 698967006075 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 698967006076 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 698967006077 acyl-activating enzyme (AAE) consensus motif; other site 698967006078 active site 698967006079 Cutinase; Region: Cutinase; pfam01083 698967006080 Putative esterase; Region: Esterase; pfam00756 698967006081 S-formylglutathione hydrolase; Region: PLN02442 698967006082 LGFP repeat; Region: LGFP; pfam08310 698967006083 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698967006084 LGFP repeat; Region: LGFP; pfam08310 698967006085 LGFP repeat; Region: LGFP; pfam08310 698967006086 Predicted esterase [General function prediction only]; Region: COG0627 698967006087 S-formylglutathione hydrolase; Region: PLN02442 698967006088 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 698967006089 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 698967006090 UbiA prenyltransferase family; Region: UbiA; pfam01040 698967006091 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698967006092 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698967006093 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698967006094 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698967006095 active site 698967006096 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698967006097 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698967006098 NAD(P) binding site [chemical binding]; other site 698967006099 catalytic residues [active] 698967006100 BCCT family transporter; Region: BCCT; cl00569 698967006101 choline dehydrogenase; Validated; Region: PRK02106 698967006102 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698967006103 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 698967006104 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698967006105 UDP-galactopyranose mutase; Region: GLF; pfam03275 698967006106 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 698967006107 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698967006108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967006109 ABC transporter signature motif; other site 698967006110 Walker B; other site 698967006111 D-loop; other site 698967006112 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698967006113 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698967006114 amidase catalytic site [active] 698967006115 Zn binding residues [ion binding]; other site 698967006116 substrate binding site [chemical binding]; other site 698967006117 LGFP repeat; Region: LGFP; pfam08310 698967006118 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 698967006119 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 698967006120 CT1975-like protein; Region: Cas_CT1975; pfam09344 698967006121 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 698967006122 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 698967006123 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 698967006124 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698967006125 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 698967006126 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 698967006127 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 698967006128 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698967006129 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698967006130 dimer interface [polypeptide binding]; other site 698967006131 ssDNA binding site [nucleotide binding]; other site 698967006132 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698967006133 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698967006134 active site 698967006135 catalytic site [active] 698967006136 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698967006137 active site 698967006138 catalytic site [active] 698967006139 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698967006140 Cna protein B-type domain; Region: Cna_B; pfam05738 698967006141 Cna protein B-type domain; Region: Cna_B; pfam05738 698967006142 Cna protein B-type domain; Region: Cna_B; pfam05738 698967006143 Cna protein B-type domain; Region: Cna_B; pfam05738 698967006144 Cna protein B-type domain; Region: Cna_B; pfam05738 698967006145 Cna protein B-type domain; Region: Cna_B; pfam05738 698967006146 HTH-like domain; Region: HTH_21; pfam13276 698967006147 potential frameshift: common BLAST hit: gi|227832250|ref|YP_002833957.1| transposase 698967006148 Integrase core domain; Region: rve; pfam00665 698967006149 Integrase core domain; Region: rve_3; cl15866 698967006150 Helix-turn-helix domain; Region: HTH_28; pfam13518 698967006151 putative transposase OrfB; Reviewed; Region: PHA02517 698967006152 HTH-like domain; Region: HTH_21; pfam13276 698967006153 Integrase core domain; Region: rve; pfam00665 698967006154 Integrase core domain; Region: rve_2; pfam13333 698967006155 glycerol kinase; Provisional; Region: glpK; PRK00047 698967006156 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 698967006157 N- and C-terminal domain interface [polypeptide binding]; other site 698967006158 active site 698967006159 MgATP binding site [chemical binding]; other site 698967006160 catalytic site [active] 698967006161 metal binding site [ion binding]; metal-binding site 698967006162 putative homotetramer interface [polypeptide binding]; other site 698967006163 glycerol binding site [chemical binding]; other site 698967006164 homodimer interface [polypeptide binding]; other site 698967006165 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 698967006166 amphipathic channel; other site 698967006167 Asn-Pro-Ala signature motifs; other site 698967006168 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 698967006169 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698967006170 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698967006171 putative acyl-acceptor binding pocket; other site 698967006172 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698967006173 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698967006174 active site 698967006175 motif I; other site 698967006176 motif II; other site 698967006177 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698967006178 seryl-tRNA synthetase; Provisional; Region: PRK05431 698967006179 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 698967006180 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 698967006181 dimer interface [polypeptide binding]; other site 698967006182 active site 698967006183 motif 1; other site 698967006184 motif 2; other site 698967006185 motif 3; other site 698967006186 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698967006187 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698967006188 DNA-binding site [nucleotide binding]; DNA binding site 698967006189 UTRA domain; Region: UTRA; pfam07702 698967006190 Septum formation; Region: Septum_form; pfam13845 698967006191 Septum formation; Region: Septum_form; pfam13845 698967006192 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 698967006193 AAA domain; Region: AAA_14; pfam13173 698967006194 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 698967006195 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698967006196 catalytic core [active] 698967006197 prephenate dehydratase; Provisional; Region: PRK11898 698967006198 Prephenate dehydratase; Region: PDT; pfam00800 698967006199 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 698967006200 putative L-Phe binding site [chemical binding]; other site 698967006201 Amidase; Region: Amidase; cl11426 698967006202 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698967006203 CAAX protease self-immunity; Region: Abi; pfam02517 698967006204 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 698967006205 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698967006206 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698967006207 amino acid carrier protein; Region: agcS; TIGR00835 698967006208 Acyltransferase family; Region: Acyl_transf_3; pfam01757 698967006209 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 698967006210 catalytic triad [active] 698967006211 catalytic triad [active] 698967006212 oxyanion hole [active] 698967006213 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698967006214 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 698967006215 putative active site [active] 698967006216 catalytic site [active] 698967006217 putative metal binding site [ion binding]; other site 698967006218 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 698967006219 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 698967006220 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698967006221 NAD binding site [chemical binding]; other site 698967006222 dimer interface [polypeptide binding]; other site 698967006223 substrate binding site [chemical binding]; other site 698967006224 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 698967006225 nudix motif; other site 698967006226 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 698967006227 quinolinate synthetase; Provisional; Region: PRK09375 698967006228 L-aspartate oxidase; Provisional; Region: PRK06175 698967006229 FAD binding domain; Region: FAD_binding_2; pfam00890 698967006230 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 698967006231 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 698967006232 dimerization interface [polypeptide binding]; other site 698967006233 active site 698967006234 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 698967006235 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 698967006236 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 698967006237 Predicted flavoprotein [General function prediction only]; Region: COG0431 698967006238 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698967006239 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 698967006240 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 698967006241 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698967006242 Lsr2; Region: Lsr2; pfam11774 698967006243 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698967006244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698967006245 active site 698967006246 phosphorylation site [posttranslational modification] 698967006247 intermolecular recognition site; other site 698967006248 dimerization interface [polypeptide binding]; other site 698967006249 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698967006250 DNA binding residues [nucleotide binding] 698967006251 dimerization interface [polypeptide binding]; other site 698967006252 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698967006253 Histidine kinase; Region: HisKA_3; pfam07730 698967006254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698967006255 ATP binding site [chemical binding]; other site 698967006256 Mg2+ binding site [ion binding]; other site 698967006257 G-X-G motif; other site 698967006258 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 698967006259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967006260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967006261 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 698967006262 active site 698967006263 catalytic site [active] 698967006264 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 698967006265 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 698967006266 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698967006267 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698967006268 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698967006269 Ligand Binding Site [chemical binding]; other site 698967006270 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698967006271 Ligand Binding Site [chemical binding]; other site 698967006272 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 698967006273 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698967006274 probable active site [active] 698967006275 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698967006276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967006277 Walker A/P-loop; other site 698967006278 ATP binding site [chemical binding]; other site 698967006279 Q-loop/lid; other site 698967006280 ABC transporter signature motif; other site 698967006281 Walker B; other site 698967006282 D-loop; other site 698967006283 H-loop/switch region; other site 698967006284 Predicted transcriptional regulators [Transcription]; Region: COG1725 698967006285 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698967006286 DNA-binding site [nucleotide binding]; DNA binding site 698967006287 LabA_like proteins; Region: LabA_like; cd06167 698967006288 putative metal binding site [ion binding]; other site 698967006289 Uncharacterized conserved protein [Function unknown]; Region: COG1432 698967006290 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698967006291 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698967006292 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698967006293 catalytic residues [active] 698967006294 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698967006295 metal-binding site [ion binding] 698967006296 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698967006297 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698967006298 metal-binding site [ion binding] 698967006299 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698967006300 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698967006301 benzoate transport; Region: 2A0115; TIGR00895 698967006302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967006303 putative substrate translocation pore; other site 698967006304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698967006305 replicative DNA helicase; Provisional; Region: PRK05636 698967006306 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 698967006307 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 698967006308 Walker A motif; other site 698967006309 ATP binding site [chemical binding]; other site 698967006310 Walker B motif; other site 698967006311 DNA binding loops [nucleotide binding] 698967006312 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 698967006313 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 698967006314 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 698967006315 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698967006316 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698967006317 dimer interface [polypeptide binding]; other site 698967006318 ssDNA binding site [nucleotide binding]; other site 698967006319 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698967006320 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 698967006321 Predicted integral membrane protein [Function unknown]; Region: COG5650 698967006322 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698967006323 Transglycosylase; Region: Transgly; pfam00912 698967006324 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698967006325 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698967006326 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698967006327 Ligand Binding Site [chemical binding]; other site 698967006328 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698967006329 Ligand Binding Site [chemical binding]; other site 698967006330 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698967006331 classical (c) SDRs; Region: SDR_c; cd05233 698967006332 NAD(P) binding site [chemical binding]; other site 698967006333 active site 698967006334 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698967006335 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698967006336 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 698967006337 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 698967006338 active site residue [active] 698967006339 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 698967006340 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698967006341 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 698967006342 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 698967006343 dimerization interface [polypeptide binding]; other site 698967006344 DPS ferroxidase diiron center [ion binding]; other site 698967006345 ion pore; other site 698967006346 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698967006347 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 698967006348 putative DNA binding site [nucleotide binding]; other site 698967006349 catalytic residue [active] 698967006350 putative H2TH interface [polypeptide binding]; other site 698967006351 putative catalytic residues [active] 698967006352 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698967006353 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698967006354 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 698967006355 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 698967006356 putative substrate binding site [chemical binding]; other site 698967006357 putative ATP binding site [chemical binding]; other site 698967006358 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 698967006359 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 698967006360 active site 698967006361 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698967006362 AAA domain; Region: AAA_31; pfam13614 698967006363 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698967006364 P-loop; other site 698967006365 Magnesium ion binding site [ion binding]; other site 698967006366 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698967006367 Magnesium ion binding site [ion binding]; other site 698967006368 MarR family; Region: MarR_2; cl17246 698967006369 Divergent AAA domain; Region: AAA_4; pfam04326 698967006370 Divergent AAA domain; Region: AAA_4; pfam04326 698967006371 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698967006372 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698967006373 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 698967006374 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698967006375 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698967006376 ATP binding site [chemical binding]; other site 698967006377 putative Mg++ binding site [ion binding]; other site 698967006378 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 698967006379 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 698967006380 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698967006381 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698967006382 HsdM N-terminal domain; Region: HsdM_N; pfam12161 698967006383 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 698967006384 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698967006385 Fic family protein [Function unknown]; Region: COG3177 698967006386 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698967006387 Fic/DOC family; Region: Fic; pfam02661 698967006388 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 698967006389 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 698967006390 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 698967006391 E-class dimer interface [polypeptide binding]; other site 698967006392 P-class dimer interface [polypeptide binding]; other site 698967006393 active site 698967006394 Cu2+ binding site [ion binding]; other site 698967006395 Zn2+ binding site [ion binding]; other site 698967006396 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 698967006397 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698967006398 active site 698967006399 HIGH motif; other site 698967006400 nucleotide binding site [chemical binding]; other site 698967006401 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698967006402 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698967006403 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698967006404 active site 698967006405 KMSKS motif; other site 698967006406 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 698967006407 tRNA binding surface [nucleotide binding]; other site 698967006408 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698967006409 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698967006410 Walker A/P-loop; other site 698967006411 ATP binding site [chemical binding]; other site 698967006412 Q-loop/lid; other site 698967006413 ABC transporter signature motif; other site 698967006414 Walker B; other site 698967006415 D-loop; other site 698967006416 H-loop/switch region; other site 698967006417 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698967006418 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698967006419 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698967006420 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698967006421 Histidine kinase; Region: HisKA_3; pfam07730 698967006422 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698967006423 ATP binding site [chemical binding]; other site 698967006424 G-X-G motif; other site 698967006425 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698967006426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698967006427 active site 698967006428 phosphorylation site [posttranslational modification] 698967006429 intermolecular recognition site; other site 698967006430 dimerization interface [polypeptide binding]; other site 698967006431 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698967006432 DNA binding residues [nucleotide binding] 698967006433 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698967006434 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698967006435 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698967006436 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698967006437 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698967006438 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698967006439 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698967006440 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698967006441 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 698967006442 NAD(P) binding site [chemical binding]; other site 698967006443 catalytic residues [active] 698967006444 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698967006445 active site 698967006446 phosphorylation site [posttranslational modification] 698967006447 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 698967006448 active site 698967006449 P-loop; other site 698967006450 phosphorylation site [posttranslational modification] 698967006451 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 698967006452 Putative esterase; Region: Esterase; pfam00756 698967006453 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 698967006454 active site 698967006455 Cobalt transport protein; Region: CbiQ; cl00463 698967006456 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967006457 ABC transporter signature motif; other site 698967006458 Walker B; other site 698967006459 D-loop; other site 698967006460 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698967006461 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698967006462 Walker A/P-loop; other site 698967006463 ATP binding site [chemical binding]; other site 698967006464 Q-loop/lid; other site 698967006465 ABC transporter signature motif; other site 698967006466 Walker B; other site 698967006467 D-loop; other site 698967006468 H-loop/switch region; other site 698967006469 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 698967006470 active site 698967006471 catalytic residues [active] 698967006472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 698967006473 hypothetical protein; Provisional; Region: PRK13663 698967006474 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698967006475 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698967006476 putative active site [active] 698967006477 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698967006478 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698967006479 SdpI/YhfL protein family; Region: SdpI; pfam13630 698967006480 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698967006481 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698967006482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698967006483 catalytic residue [active] 698967006484 anthranilate synthase component I; Provisional; Region: PRK13564 698967006485 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 698967006486 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698967006487 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698967006488 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698967006489 glutamine binding [chemical binding]; other site 698967006490 catalytic triad [active] 698967006491 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 698967006492 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698967006493 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698967006494 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 698967006495 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698967006496 active site 698967006497 ribulose/triose binding site [chemical binding]; other site 698967006498 phosphate binding site [ion binding]; other site 698967006499 substrate (anthranilate) binding pocket [chemical binding]; other site 698967006500 product (indole) binding pocket [chemical binding]; other site 698967006501 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 698967006502 active site 698967006503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 698967006504 pantoate--beta-alanine ligase; Region: panC; TIGR00018 698967006505 Pantoate-beta-alanine ligase; Region: PanC; cd00560 698967006506 active site 698967006507 ATP-binding site [chemical binding]; other site 698967006508 pantoate-binding site; other site 698967006509 HXXH motif; other site 698967006510 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 698967006511 oligomerization interface [polypeptide binding]; other site 698967006512 active site 698967006513 metal binding site [ion binding]; metal-binding site 698967006514 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698967006515 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698967006516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698967006517 catalytic residue [active] 698967006518 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 698967006519 substrate binding site [chemical binding]; other site 698967006520 active site 698967006521 catalytic residues [active] 698967006522 heterodimer interface [polypeptide binding]; other site 698967006523 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698967006524 iron-sulfur cluster [ion binding]; other site 698967006525 [2Fe-2S] cluster binding site [ion binding]; other site 698967006526 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 698967006527 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698967006528 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 698967006529 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 698967006530 hypothetical protein; Validated; Region: PRK00228 698967006531 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 698967006532 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 698967006533 active site 698967006534 NTP binding site [chemical binding]; other site 698967006535 metal binding triad [ion binding]; metal-binding site 698967006536 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 698967006537 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698967006538 Zn2+ binding site [ion binding]; other site 698967006539 Mg2+ binding site [ion binding]; other site 698967006540 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 698967006541 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698967006542 active site 698967006543 Ap6A binding site [chemical binding]; other site 698967006544 nudix motif; other site 698967006545 metal binding site [ion binding]; metal-binding site 698967006546 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 698967006547 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 698967006548 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 698967006549 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698967006550 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698967006551 DNA binding residues [nucleotide binding] 698967006552 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 698967006553 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698967006554 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698967006555 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698967006556 catalytic residues [active] 698967006557 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698967006558 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698967006559 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 698967006560 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 698967006561 active site 698967006562 metal binding site [ion binding]; metal-binding site 698967006563 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 698967006564 ParB-like nuclease domain; Region: ParBc; pfam02195 698967006565 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698967006566 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698967006567 P-loop; other site 698967006568 Magnesium ion binding site [ion binding]; other site 698967006569 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698967006570 Magnesium ion binding site [ion binding]; other site 698967006571 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 698967006572 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 698967006573 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 698967006574 ribonuclease P; Reviewed; Region: rnpA; PRK03459 698967006575 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399