-- dump date 20140619_050941 -- class Genbank::misc_feature -- table misc_feature_note -- id note 698968000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 698968000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968000003 Walker A motif; other site 698968000004 ATP binding site [chemical binding]; other site 698968000005 Walker B motif; other site 698968000006 arginine finger; other site 698968000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 698968000008 DnaA box-binding interface [nucleotide binding]; other site 698968000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 698968000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 698968000011 putative DNA binding surface [nucleotide binding]; other site 698968000012 dimer interface [polypeptide binding]; other site 698968000013 beta-clamp/clamp loader binding surface; other site 698968000014 beta-clamp/translesion DNA polymerase binding surface; other site 698968000015 recombination protein F; Reviewed; Region: recF; PRK00064 698968000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 698968000017 Walker A/P-loop; other site 698968000018 ATP binding site [chemical binding]; other site 698968000019 Q-loop/lid; other site 698968000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968000021 ABC transporter signature motif; other site 698968000022 Walker B; other site 698968000023 D-loop; other site 698968000024 H-loop/switch region; other site 698968000025 hypothetical protein; Provisional; Region: PRK00111 698968000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 698968000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698968000028 ATP binding site [chemical binding]; other site 698968000029 Mg2+ binding site [ion binding]; other site 698968000030 G-X-G motif; other site 698968000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698968000032 anchoring element; other site 698968000033 dimer interface [polypeptide binding]; other site 698968000034 ATP binding site [chemical binding]; other site 698968000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 698968000036 active site 698968000037 putative metal-binding site [ion binding]; other site 698968000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698968000039 DNA gyrase subunit A; Validated; Region: PRK05560 698968000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 698968000041 CAP-like domain; other site 698968000042 active site 698968000043 primary dimer interface [polypeptide binding]; other site 698968000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698968000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698968000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698968000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698968000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698968000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698968000050 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 698968000051 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698968000052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698968000053 DNA-binding site [nucleotide binding]; DNA binding site 698968000054 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698968000055 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698968000056 L-lactate permease; Region: Lactate_perm; cl00701 698968000057 Cadherin repeat-like domain; Region: CA_like; cl15786 698968000058 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698968000059 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698968000060 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 698968000061 Walker A/P-loop; other site 698968000062 ATP binding site [chemical binding]; other site 698968000063 Q-loop/lid; other site 698968000064 ABC transporter signature motif; other site 698968000065 Walker B; other site 698968000066 D-loop; other site 698968000067 H-loop/switch region; other site 698968000068 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698968000069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968000070 Walker A/P-loop; other site 698968000071 ATP binding site [chemical binding]; other site 698968000072 Q-loop/lid; other site 698968000073 ABC transporter signature motif; other site 698968000074 Walker B; other site 698968000075 D-loop; other site 698968000076 H-loop/switch region; other site 698968000077 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698968000078 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 698968000079 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698968000080 putative ligand binding site [chemical binding]; other site 698968000081 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698968000082 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698968000083 TM-ABC transporter signature motif; other site 698968000084 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698968000085 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698968000086 Walker A/P-loop; other site 698968000087 ATP binding site [chemical binding]; other site 698968000088 Q-loop/lid; other site 698968000089 ABC transporter signature motif; other site 698968000090 Walker B; other site 698968000091 D-loop; other site 698968000092 H-loop/switch region; other site 698968000093 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698968000094 active site 698968000095 Helix-turn-helix domain; Region: HTH_28; pfam13518 698968000096 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698968000097 Integrase core domain; Region: rve_3; cl15866 698968000098 Rhomboid family; Region: Rhomboid; pfam01694 698968000099 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 698968000100 ThiC-associated domain; Region: ThiC-associated; pfam13667 698968000101 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 698968000102 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698968000103 thiamine phosphate binding site [chemical binding]; other site 698968000104 active site 698968000105 pyrophosphate binding site [ion binding]; other site 698968000106 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698968000107 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 698968000108 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 698968000109 ThiS interaction site; other site 698968000110 putative active site [active] 698968000111 tetramer interface [polypeptide binding]; other site 698968000112 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 698968000113 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698968000114 ATP binding site [chemical binding]; other site 698968000115 substrate interface [chemical binding]; other site 698968000116 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698968000117 active site residue [active] 698968000118 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 698968000119 dimer interface [polypeptide binding]; other site 698968000120 substrate binding site [chemical binding]; other site 698968000121 ATP binding site [chemical binding]; other site 698968000122 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 698968000123 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 698968000124 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 698968000125 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 698968000126 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 698968000127 Helix-turn-helix domain; Region: HTH_28; pfam13518 698968000128 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698968000129 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698968000130 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698968000131 MULE transposase domain; Region: MULE; pfam10551 698968000132 putative septation inhibitor protein; Reviewed; Region: PRK00159 698968000133 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698968000134 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698968000135 active site 698968000136 ATP binding site [chemical binding]; other site 698968000137 substrate binding site [chemical binding]; other site 698968000138 activation loop (A-loop); other site 698968000139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698968000140 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698968000141 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698968000142 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698968000143 PASTA domain; Region: PASTA; pfam03793 698968000144 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698968000145 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698968000146 active site 698968000147 ATP binding site [chemical binding]; other site 698968000148 substrate binding site [chemical binding]; other site 698968000149 activation loop (A-loop); other site 698968000150 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698968000151 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698968000152 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 698968000153 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 698968000154 Protein phosphatase 2C; Region: PP2C; pfam00481 698968000155 active site 698968000156 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698968000157 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698968000158 phosphopeptide binding site; other site 698968000159 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 698968000160 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698968000161 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698968000162 phosphopeptide binding site; other site 698968000163 DDE domain; Region: DDE_Tnp_IS240; pfam13610 698968000164 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 698968000165 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698968000166 metal-binding site [ion binding] 698968000167 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698968000168 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698968000169 dimerization interface [polypeptide binding]; other site 698968000170 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698968000171 dimer interface [polypeptide binding]; other site 698968000172 phosphorylation site [posttranslational modification] 698968000173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698968000174 ATP binding site [chemical binding]; other site 698968000175 Mg2+ binding site [ion binding]; other site 698968000176 G-X-G motif; other site 698968000177 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698968000178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968000179 active site 698968000180 phosphorylation site [posttranslational modification] 698968000181 intermolecular recognition site; other site 698968000182 dimerization interface [polypeptide binding]; other site 698968000183 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698968000184 DNA binding site [nucleotide binding] 698968000185 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 698968000186 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 698968000187 Multicopper oxidase; Region: Cu-oxidase; pfam00394 698968000188 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 698968000189 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698968000190 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698968000191 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698968000192 dimerization interface [polypeptide binding]; other site 698968000193 putative DNA binding site [nucleotide binding]; other site 698968000194 putative Zn2+ binding site [ion binding]; other site 698968000195 Cadmium resistance transporter; Region: Cad; pfam03596 698968000196 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 698968000197 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 698968000198 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698968000199 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698968000200 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698968000201 mercuric reductase; Region: MerA; TIGR02053 698968000202 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698968000203 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698968000204 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698968000205 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698968000206 catalytic residues [active] 698968000207 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698968000208 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 698968000209 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 698968000210 DNA binding residues [nucleotide binding] 698968000211 dimer interface [polypeptide binding]; other site 698968000212 metal binding site [ion binding]; metal-binding site 698968000213 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 698968000214 NIPSNAP; Region: NIPSNAP; pfam07978 698968000215 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 698968000216 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 698968000217 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698968000218 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 698968000219 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698968000220 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698968000221 dimerization interface [polypeptide binding]; other site 698968000222 putative DNA binding site [nucleotide binding]; other site 698968000223 putative Zn2+ binding site [ion binding]; other site 698968000224 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 698968000225 arsenical-resistance protein; Region: acr3; TIGR00832 698968000226 Low molecular weight phosphatase family; Region: LMWPc; cl00105 698968000227 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 698968000228 active site 698968000229 Predicted permeases [General function prediction only]; Region: COG0701 698968000230 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698968000231 dimerization interface [polypeptide binding]; other site 698968000232 putative DNA binding site [nucleotide binding]; other site 698968000233 putative Zn2+ binding site [ion binding]; other site 698968000234 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698968000235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698968000236 non-specific DNA binding site [nucleotide binding]; other site 698968000237 salt bridge; other site 698968000238 sequence-specific DNA binding site [nucleotide binding]; other site 698968000239 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 698968000240 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 698968000241 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 698968000242 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698968000243 Walker A/P-loop; other site 698968000244 ATP binding site [chemical binding]; other site 698968000245 Q-loop/lid; other site 698968000246 ABC transporter signature motif; other site 698968000247 Walker B; other site 698968000248 D-loop; other site 698968000249 H-loop/switch region; other site 698968000250 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698968000251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968000252 active site 698968000253 phosphorylation site [posttranslational modification] 698968000254 intermolecular recognition site; other site 698968000255 dimerization interface [polypeptide binding]; other site 698968000256 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698968000257 DNA binding residues [nucleotide binding] 698968000258 dimerization interface [polypeptide binding]; other site 698968000259 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698968000260 Histidine kinase; Region: HisKA_3; pfam07730 698968000261 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698968000262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698968000263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968000264 dimer interface [polypeptide binding]; other site 698968000265 conserved gate region; other site 698968000266 putative PBP binding loops; other site 698968000267 ABC-ATPase subunit interface; other site 698968000268 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 698968000269 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 698968000270 Walker A/P-loop; other site 698968000271 ATP binding site [chemical binding]; other site 698968000272 Q-loop/lid; other site 698968000273 ABC transporter signature motif; other site 698968000274 Walker B; other site 698968000275 D-loop; other site 698968000276 H-loop/switch region; other site 698968000277 Anti-sigma-K factor rskA; Region: RskA; pfam10099 698968000278 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 698968000279 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698968000280 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698968000281 DNA binding residues [nucleotide binding] 698968000282 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698968000283 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698968000284 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 698968000285 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698968000286 catalytic residues [active] 698968000287 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 698968000288 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698968000289 DNA binding residues [nucleotide binding] 698968000290 dimer interface [polypeptide binding]; other site 698968000291 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 698968000292 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 698968000293 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 698968000294 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 698968000295 putative metal binding site [ion binding]; other site 698968000296 biotin synthase; Validated; Region: PRK06256 698968000297 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698968000298 FeS/SAM binding site; other site 698968000299 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698968000300 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 698968000301 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 698968000302 putative ligand binding residues [chemical binding]; other site 698968000303 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698968000304 ABC-ATPase subunit interface; other site 698968000305 dimer interface [polypeptide binding]; other site 698968000306 putative PBP binding regions; other site 698968000307 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698968000308 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698968000309 Walker A/P-loop; other site 698968000310 ATP binding site [chemical binding]; other site 698968000311 Q-loop/lid; other site 698968000312 ABC transporter signature motif; other site 698968000313 Walker B; other site 698968000314 D-loop; other site 698968000315 H-loop/switch region; other site 698968000316 Uncharacterized conserved protein [Function unknown]; Region: COG5646 698968000317 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 698968000318 DNA photolyase; Region: DNA_photolyase; pfam00875 698968000319 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 698968000320 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 698968000321 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 698968000322 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 698968000323 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 698968000324 Lipase (class 2); Region: Lipase_2; pfam01674 698968000325 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 698968000326 dimer interface [polypeptide binding]; other site 698968000327 FMN binding site [chemical binding]; other site 698968000328 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698968000329 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 698968000330 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 698968000331 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 698968000332 trimer interface [polypeptide binding]; other site 698968000333 putative metal binding site [ion binding]; other site 698968000334 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698968000335 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 698968000336 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 698968000337 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 698968000338 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698968000339 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698968000340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 698968000341 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698968000342 MarR family; Region: MarR; pfam01047 698968000343 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 698968000344 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698968000345 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698968000346 hypothetical protein; Provisional; Region: PRK10621 698968000347 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698968000348 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 698968000349 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968000350 ATP binding site [chemical binding]; other site 698968000351 putative Mg++ binding site [ion binding]; other site 698968000352 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968000353 nucleotide binding region [chemical binding]; other site 698968000354 Helicase associated domain (HA2); Region: HA2; pfam04408 698968000355 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 698968000356 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 698968000357 active site 698968000358 substrate binding site [chemical binding]; other site 698968000359 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 698968000360 trimer interface [polypeptide binding]; other site 698968000361 CoA binding site [chemical binding]; other site 698968000362 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698968000363 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 698968000364 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698968000365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968000366 NAD(P) binding site [chemical binding]; other site 698968000367 active site 698968000368 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698968000369 Helix-turn-helix domain; Region: HTH_28; pfam13518 698968000370 Integrase core domain; Region: rve_2; pfam13333 698968000371 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 698968000372 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 698968000373 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698968000374 RNA binding surface [nucleotide binding]; other site 698968000375 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698968000376 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698968000377 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698968000378 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 698968000379 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 698968000380 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 698968000381 active site 698968000382 Zn binding site [ion binding]; other site 698968000383 Protease prsW family; Region: PrsW-protease; pfam13367 698968000384 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698968000385 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 698968000386 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 698968000387 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 698968000388 short chain dehydrogenase; Provisional; Region: PRK07904 698968000389 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698968000390 NAD(P) binding site [chemical binding]; other site 698968000391 active site 698968000392 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698968000393 FAD binding domain; Region: FAD_binding_4; pfam01565 698968000394 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 698968000395 Predicted membrane protein [Function unknown]; Region: COG2246 698968000396 GtrA-like protein; Region: GtrA; pfam04138 698968000397 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698968000398 putative active site [active] 698968000399 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698968000400 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698968000401 active site 698968000402 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698968000403 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698968000404 intersubunit interface [polypeptide binding]; other site 698968000405 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698968000406 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698968000407 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698968000408 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698968000409 ABC-ATPase subunit interface; other site 698968000410 dimer interface [polypeptide binding]; other site 698968000411 putative PBP binding regions; other site 698968000412 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698968000413 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698968000414 ABC-ATPase subunit interface; other site 698968000415 dimer interface [polypeptide binding]; other site 698968000416 putative PBP binding regions; other site 698968000417 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698968000418 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698968000419 intersubunit interface [polypeptide binding]; other site 698968000420 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 698968000421 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 698968000422 Walker A/P-loop; other site 698968000423 ATP binding site [chemical binding]; other site 698968000424 Q-loop/lid; other site 698968000425 ABC transporter signature motif; other site 698968000426 Walker B; other site 698968000427 D-loop; other site 698968000428 H-loop/switch region; other site 698968000429 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 698968000430 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698968000431 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698968000432 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698968000433 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698968000434 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 698968000435 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 698968000436 NAD(P) binding site [chemical binding]; other site 698968000437 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 698968000438 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698968000439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968000440 homodimer interface [polypeptide binding]; other site 698968000441 catalytic residue [active] 698968000442 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 698968000443 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 698968000444 transmembrane helices; other site 698968000445 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698968000446 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 698968000447 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698968000448 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698968000449 DNA-binding site [nucleotide binding]; DNA binding site 698968000450 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698968000451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968000452 homodimer interface [polypeptide binding]; other site 698968000453 catalytic residue [active] 698968000454 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 698968000455 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 698968000456 active site 698968000457 multimer interface [polypeptide binding]; other site 698968000458 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 698968000459 predicted active site [active] 698968000460 catalytic triad [active] 698968000461 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 698968000462 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698968000463 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698968000464 active site 698968000465 catalytic site [active] 698968000466 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698968000467 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698968000468 active site 698968000469 catalytic site [active] 698968000470 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698968000471 metal ion-dependent adhesion site (MIDAS); other site 698968000472 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 698968000473 prephenate dehydrogenase; Validated; Region: PRK08507 698968000474 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 698968000475 nucleoside/Zn binding site; other site 698968000476 dimer interface [polypeptide binding]; other site 698968000477 catalytic motif [active] 698968000478 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 698968000479 DNA binding residues [nucleotide binding] 698968000480 PIN domain; Region: PIN_3; pfam13470 698968000481 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 698968000482 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 698968000483 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 698968000484 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 698968000485 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 698968000486 active site 698968000487 HIGH motif; other site 698968000488 nucleotide binding site [chemical binding]; other site 698968000489 active site 698968000490 KMSKS motif; other site 698968000491 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 698968000492 fructuronate transporter; Provisional; Region: PRK10034; cl15264 698968000493 Shikimate kinase; Region: SKI; pfam01202 698968000494 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 698968000495 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 698968000496 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 698968000497 putative NAD(P) binding site [chemical binding]; other site 698968000498 catalytic Zn binding site [ion binding]; other site 698968000499 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 698968000500 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 698968000501 NADP binding site [chemical binding]; other site 698968000502 homodimer interface [polypeptide binding]; other site 698968000503 active site 698968000504 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 698968000505 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698968000506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968000507 homodimer interface [polypeptide binding]; other site 698968000508 catalytic residue [active] 698968000509 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 698968000510 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 698968000511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968000512 Walker A motif; other site 698968000513 ATP binding site [chemical binding]; other site 698968000514 Walker B motif; other site 698968000515 arginine finger; other site 698968000516 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 698968000517 hypothetical protein; Validated; Region: PRK00153 698968000518 recombination protein RecR; Reviewed; Region: recR; PRK00076 698968000519 RecR protein; Region: RecR; pfam02132 698968000520 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 698968000521 putative active site [active] 698968000522 putative metal-binding site [ion binding]; other site 698968000523 tetramer interface [polypeptide binding]; other site 698968000524 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698968000525 catalytic triad [active] 698968000526 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 698968000527 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698968000528 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 698968000529 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 698968000530 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698968000531 active site 698968000532 catalytic site [active] 698968000533 substrate binding site [chemical binding]; other site 698968000534 potential frameshift: common BLAST hit: gi|38232888|ref|NP_938655.1| nitroreductase 698968000535 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 698968000536 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 698968000537 dimer interface [polypeptide binding]; other site 698968000538 FMN binding site [chemical binding]; other site 698968000539 2-isopropylmalate synthase; Validated; Region: PRK03739 698968000540 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 698968000541 active site 698968000542 catalytic residues [active] 698968000543 metal binding site [ion binding]; metal-binding site 698968000544 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 698968000545 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698968000546 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698968000547 DNA binding residues [nucleotide binding] 698968000548 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698968000549 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698968000550 active site 698968000551 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 698968000552 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698968000553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968000554 putative substrate translocation pore; other site 698968000555 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 698968000556 intersubunit interface [polypeptide binding]; other site 698968000557 active site 698968000558 catalytic residue [active] 698968000559 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 698968000560 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 698968000561 active site 698968000562 substrate binding site [chemical binding]; other site 698968000563 metal binding site [ion binding]; metal-binding site 698968000564 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 698968000565 aspartate kinase; Reviewed; Region: PRK06635 698968000566 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 698968000567 putative nucleotide binding site [chemical binding]; other site 698968000568 putative catalytic residues [active] 698968000569 putative Mg ion binding site [ion binding]; other site 698968000570 putative aspartate binding site [chemical binding]; other site 698968000571 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 698968000572 putative allosteric regulatory site; other site 698968000573 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 698968000574 putative allosteric regulatory residue; other site 698968000575 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 698968000576 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698968000577 potential frameshift: common BLAST hit: gi|172040440|ref|YP_001800154.1| transposase for insertion sequence 698968000578 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698968000579 Helix-turn-helix domain; Region: HTH_28; pfam13518 698968000580 potential frameshift: common BLAST hit: gi|38234519|ref|NP_940286.1| transposase 698968000581 HTH-like domain; Region: HTH_21; pfam13276 698968000582 Integrase core domain; Region: rve; pfam00665 698968000583 Cna protein B-type domain; Region: Cna_B; pfam05738 698968000584 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698968000585 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698968000586 active site 698968000587 catalytic site [active] 698968000588 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698968000589 active site 698968000590 catalytic site [active] 698968000591 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698968000592 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698968000593 DNA binding residues [nucleotide binding] 698968000594 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 698968000595 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 698968000596 heme binding pocket [chemical binding]; other site 698968000597 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698968000598 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 698968000599 Walker A/P-loop; other site 698968000600 ATP binding site [chemical binding]; other site 698968000601 Q-loop/lid; other site 698968000602 ABC transporter signature motif; other site 698968000603 Walker B; other site 698968000604 D-loop; other site 698968000605 H-loop/switch region; other site 698968000606 TOBE domain; Region: TOBE_2; pfam08402 698968000607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968000608 dimer interface [polypeptide binding]; other site 698968000609 conserved gate region; other site 698968000610 ABC-ATPase subunit interface; other site 698968000611 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698968000612 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 698968000613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968000614 putative substrate translocation pore; other site 698968000615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968000616 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698968000617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968000618 active site 698968000619 phosphorylation site [posttranslational modification] 698968000620 intermolecular recognition site; other site 698968000621 dimerization interface [polypeptide binding]; other site 698968000622 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698968000623 DNA binding site [nucleotide binding] 698968000624 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698968000625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698968000626 dimer interface [polypeptide binding]; other site 698968000627 phosphorylation site [posttranslational modification] 698968000628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698968000629 ATP binding site [chemical binding]; other site 698968000630 Mg2+ binding site [ion binding]; other site 698968000631 G-X-G motif; other site 698968000632 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 698968000633 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 698968000634 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 698968000635 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 698968000636 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698968000637 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 698968000638 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 698968000639 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698968000640 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 698968000641 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698968000642 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698968000643 Predicted membrane protein [Function unknown]; Region: COG1511 698968000644 Predicted membrane protein [Function unknown]; Region: COG1511 698968000645 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698968000646 putative active site [active] 698968000647 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698968000648 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 698968000649 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698968000650 putative active site [active] 698968000651 putative metal binding site [ion binding]; other site 698968000652 Yqey-like protein; Region: YqeY; pfam09424 698968000653 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698968000654 Transglycosylase; Region: Transgly; pfam00912 698968000655 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698968000656 PASTA domain; Region: PASTA; pfam03793 698968000657 Transcription factor WhiB; Region: Whib; pfam02467 698968000658 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 698968000659 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 698968000660 homotrimer interaction site [polypeptide binding]; other site 698968000661 putative active site [active] 698968000662 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698968000663 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698968000664 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698968000665 ligand binding site [chemical binding]; other site 698968000666 flexible hinge region; other site 698968000667 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698968000668 putative switch regulator; other site 698968000669 non-specific DNA interactions [nucleotide binding]; other site 698968000670 DNA binding site [nucleotide binding] 698968000671 sequence specific DNA binding site [nucleotide binding]; other site 698968000672 putative cAMP binding site [chemical binding]; other site 698968000673 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 698968000674 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698968000675 minor groove reading motif; other site 698968000676 helix-hairpin-helix signature motif; other site 698968000677 substrate binding pocket [chemical binding]; other site 698968000678 active site 698968000679 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 698968000680 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698968000681 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698968000682 catalytic residues [active] 698968000683 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 698968000684 putative active site [active] 698968000685 putative CoA binding site [chemical binding]; other site 698968000686 nudix motif; other site 698968000687 metal binding site [ion binding]; metal-binding site 698968000688 Colicin V production protein; Region: Colicin_V; pfam02674 698968000689 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 698968000690 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698968000691 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698968000692 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698968000693 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 698968000694 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698968000695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968000696 motif II; other site 698968000697 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 698968000698 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 698968000699 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 698968000700 ATP binding site [chemical binding]; other site 698968000701 Walker A motif; other site 698968000702 hexamer interface [polypeptide binding]; other site 698968000703 Walker B motif; other site 698968000704 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 698968000705 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 698968000706 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 698968000707 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968000708 ATP binding site [chemical binding]; other site 698968000709 putative Mg++ binding site [ion binding]; other site 698968000710 nucleotide binding region [chemical binding]; other site 698968000711 helicase superfamily c-terminal domain; Region: HELICc; smart00490 698968000712 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 698968000713 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698968000714 DNA-binding site [nucleotide binding]; DNA binding site 698968000715 RNA-binding motif; other site 698968000716 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698968000717 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698968000718 Walker A/P-loop; other site 698968000719 ATP binding site [chemical binding]; other site 698968000720 Q-loop/lid; other site 698968000721 ABC transporter signature motif; other site 698968000722 Walker B; other site 698968000723 D-loop; other site 698968000724 H-loop/switch region; other site 698968000725 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698968000726 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698968000727 Walker A/P-loop; other site 698968000728 ATP binding site [chemical binding]; other site 698968000729 Q-loop/lid; other site 698968000730 ABC transporter signature motif; other site 698968000731 Walker B; other site 698968000732 D-loop; other site 698968000733 H-loop/switch region; other site 698968000734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968000735 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698968000736 putative substrate translocation pore; other site 698968000737 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698968000738 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 698968000739 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698968000740 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 698968000741 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698968000742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968000743 dimer interface [polypeptide binding]; other site 698968000744 conserved gate region; other site 698968000745 putative PBP binding loops; other site 698968000746 ABC-ATPase subunit interface; other site 698968000747 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698968000748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968000749 NAD(P) binding site [chemical binding]; other site 698968000750 active site 698968000751 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 698968000752 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 698968000753 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 698968000754 active site 698968000755 interdomain interaction site; other site 698968000756 putative metal-binding site [ion binding]; other site 698968000757 nucleotide binding site [chemical binding]; other site 698968000758 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 698968000759 domain I; other site 698968000760 DNA binding groove [nucleotide binding] 698968000761 phosphate binding site [ion binding]; other site 698968000762 domain II; other site 698968000763 domain III; other site 698968000764 nucleotide binding site [chemical binding]; other site 698968000765 catalytic site [active] 698968000766 domain IV; other site 698968000767 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 698968000768 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698968000769 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698968000770 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698968000771 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698968000772 active site 698968000773 Predicted membrane protein [Function unknown]; Region: COG1297 698968000774 putative oligopeptide transporter, OPT family; Region: TIGR00733 698968000775 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 698968000776 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698968000777 catalytic site [active] 698968000778 Asp-box motif; other site 698968000779 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698968000780 dimerization interface [polypeptide binding]; other site 698968000781 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698968000782 cyclase homology domain; Region: CHD; cd07302 698968000783 nucleotidyl binding site; other site 698968000784 metal binding site [ion binding]; metal-binding site 698968000785 dimer interface [polypeptide binding]; other site 698968000786 DNA polymerase III subunit delta'; Validated; Region: PRK07940 698968000787 DNA polymerase III subunit delta'; Validated; Region: PRK08485 698968000788 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 698968000789 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 698968000790 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698968000791 active site 698968000792 catalytic residues [active] 698968000793 DNA binding site [nucleotide binding] 698968000794 Int/Topo IB signature motif; other site 698968000795 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 698968000796 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698968000797 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698968000798 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698968000799 Fic family protein [Function unknown]; Region: COG3177 698968000800 Fic/DOC family; Region: Fic; pfam02661 698968000801 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698968000802 Trypsin; Region: Trypsin; pfam00089 698968000803 active site 698968000804 putative transposase OrfB; Reviewed; Region: PHA02517 698968000805 HTH-like domain; Region: HTH_21; pfam13276 698968000806 Integrase core domain; Region: rve; pfam00665 698968000807 Integrase core domain; Region: rve_3; pfam13683 698968000808 Transposase; Region: HTH_Tnp_1; cl17663 698968000809 acyl-CoA synthetase; Validated; Region: PRK07788 698968000810 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698968000811 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698968000812 acyl-activating enzyme (AAE) consensus motif; other site 698968000813 acyl-activating enzyme (AAE) consensus motif; other site 698968000814 AMP binding site [chemical binding]; other site 698968000815 active site 698968000816 CoA binding site [chemical binding]; other site 698968000817 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 698968000818 active site 698968000819 catalytic triad [active] 698968000820 oxyanion hole [active] 698968000821 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 698968000822 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 698968000823 substrate binding site; other site 698968000824 tetramer interface; other site 698968000825 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 698968000826 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 698968000827 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 698968000828 NADP binding site [chemical binding]; other site 698968000829 active site 698968000830 putative substrate binding site [chemical binding]; other site 698968000831 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 698968000832 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 698968000833 NAD binding site [chemical binding]; other site 698968000834 substrate binding site [chemical binding]; other site 698968000835 homodimer interface [polypeptide binding]; other site 698968000836 active site 698968000837 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 698968000838 Zn binding site [ion binding]; other site 698968000839 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 698968000840 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698968000841 Putative esterase; Region: Esterase; pfam00756 698968000842 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 698968000843 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 698968000844 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698968000845 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698968000846 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698968000847 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698968000848 non-specific DNA binding site [nucleotide binding]; other site 698968000849 salt bridge; other site 698968000850 sequence-specific DNA binding site [nucleotide binding]; other site 698968000851 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 698968000852 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698968000853 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 698968000854 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 698968000855 putative Iron-sulfur protein interface [polypeptide binding]; other site 698968000856 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 698968000857 proximal heme binding site [chemical binding]; other site 698968000858 distal heme binding site [chemical binding]; other site 698968000859 putative dimer interface [polypeptide binding]; other site 698968000860 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 698968000861 L-aspartate oxidase; Provisional; Region: PRK06175 698968000862 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 698968000863 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 698968000864 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 698968000865 Predicted membrane protein [Function unknown]; Region: COG2733 698968000866 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 698968000867 Class I aldolases; Region: Aldolase_Class_I; cl17187 698968000868 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698968000869 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 698968000870 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698968000871 FeS/SAM binding site; other site 698968000872 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 698968000873 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698968000874 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 698968000875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698968000876 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 698968000877 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 698968000878 FAD binding domain; Region: FAD_binding_4; pfam01565 698968000879 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 698968000880 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698968000881 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698968000882 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698968000883 acyl-activating enzyme (AAE) consensus motif; other site 698968000884 AMP binding site [chemical binding]; other site 698968000885 active site 698968000886 CoA binding site [chemical binding]; other site 698968000887 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698968000888 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698968000889 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698968000890 acyl-activating enzyme (AAE) consensus motif; other site 698968000891 AMP binding site [chemical binding]; other site 698968000892 active site 698968000893 CoA binding site [chemical binding]; other site 698968000894 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 698968000895 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 698968000896 putative ADP-binding pocket [chemical binding]; other site 698968000897 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698968000898 catalytic core [active] 698968000899 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698968000900 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698968000901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698968000902 dimer interface [polypeptide binding]; other site 698968000903 phosphorylation site [posttranslational modification] 698968000904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698968000905 ATP binding site [chemical binding]; other site 698968000906 Mg2+ binding site [ion binding]; other site 698968000907 G-X-G motif; other site 698968000908 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698968000909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968000910 active site 698968000911 phosphorylation site [posttranslational modification] 698968000912 intermolecular recognition site; other site 698968000913 dimerization interface [polypeptide binding]; other site 698968000914 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698968000915 DNA binding site [nucleotide binding] 698968000916 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 698968000917 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 698968000918 DNA binding domain, excisionase family; Region: excise; TIGR01764 698968000919 Thioredoxin; Region: Thioredoxin_4; cl17273 698968000920 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698968000921 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698968000922 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 698968000923 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968000924 motif II; other site 698968000925 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 698968000926 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 698968000927 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 698968000928 tRNA; other site 698968000929 putative tRNA binding site [nucleotide binding]; other site 698968000930 putative NADP binding site [chemical binding]; other site 698968000931 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 698968000932 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 698968000933 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 698968000934 domain interfaces; other site 698968000935 active site 698968000936 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 698968000937 active site 698968000938 homodimer interface [polypeptide binding]; other site 698968000939 SAM binding site [chemical binding]; other site 698968000940 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 698968000941 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 698968000942 active site 698968000943 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 698968000944 dimer interface [polypeptide binding]; other site 698968000945 active site 698968000946 Schiff base residues; other site 698968000947 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 698968000948 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698968000949 Predicted membrane protein [Function unknown]; Region: COG2311 698968000950 Protein of unknown function (DUF418); Region: DUF418; pfam04235 698968000951 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 698968000952 substrate binding site [chemical binding]; other site 698968000953 active site 698968000954 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 698968000955 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 698968000956 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698968000957 inhibitor-cofactor binding pocket; inhibition site 698968000958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968000959 catalytic residue [active] 698968000960 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698968000961 catalytic core [active] 698968000962 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698968000963 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698968000964 catalytic residues [active] 698968000965 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698968000966 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698968000967 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 698968000968 ResB-like family; Region: ResB; pfam05140 698968000969 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 698968000970 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698968000971 dimerization interface [polypeptide binding]; other site 698968000972 putative DNA binding site [nucleotide binding]; other site 698968000973 putative Zn2+ binding site [ion binding]; other site 698968000974 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 698968000975 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 698968000976 UbiA prenyltransferase family; Region: UbiA; pfam01040 698968000977 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698968000978 active site 698968000979 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698968000980 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 698968000981 acyl-activating enzyme (AAE) consensus motif; other site 698968000982 AMP binding site [chemical binding]; other site 698968000983 active site 698968000984 CoA binding site [chemical binding]; other site 698968000985 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 698968000986 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698968000987 substrate binding site [chemical binding]; other site 698968000988 oxyanion hole (OAH) forming residues; other site 698968000989 trimer interface [polypeptide binding]; other site 698968000990 O-succinylbenzoate synthase; Provisional; Region: PRK02901 698968000991 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 698968000992 active site 698968000993 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 698968000994 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 698968000995 dimer interface [polypeptide binding]; other site 698968000996 tetramer interface [polypeptide binding]; other site 698968000997 PYR/PP interface [polypeptide binding]; other site 698968000998 TPP binding site [chemical binding]; other site 698968000999 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 698968001000 TPP-binding site; other site 698968001001 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698968001002 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 698968001003 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 698968001004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968001005 S-adenosylmethionine binding site [chemical binding]; other site 698968001006 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 698968001007 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 698968001008 NAD binding site [chemical binding]; other site 698968001009 dimer interface [polypeptide binding]; other site 698968001010 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698968001011 substrate binding site [chemical binding]; other site 698968001012 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 698968001013 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698968001014 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698968001015 substrate binding pocket [chemical binding]; other site 698968001016 chain length determination region; other site 698968001017 substrate-Mg2+ binding site; other site 698968001018 catalytic residues [active] 698968001019 aspartate-rich region 1; other site 698968001020 active site lid residues [active] 698968001021 aspartate-rich region 2; other site 698968001022 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 698968001023 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 698968001024 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 698968001025 putative homodimer interface [polypeptide binding]; other site 698968001026 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 698968001027 heterodimer interface [polypeptide binding]; other site 698968001028 homodimer interface [polypeptide binding]; other site 698968001029 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 698968001030 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 698968001031 23S rRNA interface [nucleotide binding]; other site 698968001032 L7/L12 interface [polypeptide binding]; other site 698968001033 putative thiostrepton binding site; other site 698968001034 L25 interface [polypeptide binding]; other site 698968001035 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 698968001036 mRNA/rRNA interface [nucleotide binding]; other site 698968001037 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 698968001038 23S rRNA interface [nucleotide binding]; other site 698968001039 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 698968001040 50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157 698968001041 L11 interface [polypeptide binding]; other site 698968001042 putative EF-Tu interaction site [polypeptide binding]; other site 698968001043 putative EF-G interaction site [polypeptide binding]; other site 698968001044 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 698968001045 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698968001046 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698968001047 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698968001048 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698968001049 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698968001050 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 698968001051 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698968001052 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698968001053 ABC-ATPase subunit interface; other site 698968001054 dimer interface [polypeptide binding]; other site 698968001055 putative PBP binding regions; other site 698968001056 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698968001057 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698968001058 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698968001059 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698968001060 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 698968001061 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 698968001062 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 698968001063 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 698968001064 RPB1 interaction site [polypeptide binding]; other site 698968001065 RPB10 interaction site [polypeptide binding]; other site 698968001066 RPB11 interaction site [polypeptide binding]; other site 698968001067 RPB3 interaction site [polypeptide binding]; other site 698968001068 RPB12 interaction site [polypeptide binding]; other site 698968001069 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 698968001070 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 698968001071 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 698968001072 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 698968001073 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 698968001074 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698968001075 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 698968001076 G-loop; other site 698968001077 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698968001078 DNA binding site [nucleotide binding] 698968001079 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 698968001080 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698968001081 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698968001082 Walker A/P-loop; other site 698968001083 ATP binding site [chemical binding]; other site 698968001084 Q-loop/lid; other site 698968001085 ABC transporter signature motif; other site 698968001086 Walker B; other site 698968001087 D-loop; other site 698968001088 H-loop/switch region; other site 698968001089 putative transposase OrfB; Reviewed; Region: PHA02517 698968001090 HTH-like domain; Region: HTH_21; pfam13276 698968001091 Integrase core domain; Region: rve; pfam00665 698968001092 Integrase core domain; Region: rve_2; pfam13333 698968001093 Homeodomain-like domain; Region: HTH_23; cl17451 698968001094 Helix-turn-helix domain; Region: HTH_28; pfam13518 698968001095 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 698968001096 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698968001097 Histidine kinase; Region: HisKA_3; pfam07730 698968001098 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698968001099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968001100 active site 698968001101 phosphorylation site [posttranslational modification] 698968001102 intermolecular recognition site; other site 698968001103 dimerization interface [polypeptide binding]; other site 698968001104 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698968001105 DNA binding residues [nucleotide binding] 698968001106 dimerization interface [polypeptide binding]; other site 698968001107 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698968001108 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698968001109 Walker A/P-loop; other site 698968001110 ATP binding site [chemical binding]; other site 698968001111 Q-loop/lid; other site 698968001112 ABC transporter signature motif; other site 698968001113 Walker B; other site 698968001114 D-loop; other site 698968001115 H-loop/switch region; other site 698968001116 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 698968001117 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698968001118 TIGR03943 family protein; Region: TIGR03943 698968001119 Predicted permeases [General function prediction only]; Region: COG0701 698968001120 Radical SAM superfamily; Region: Radical_SAM; pfam04055 698968001121 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698968001122 FeS/SAM binding site; other site 698968001123 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 698968001124 Class III ribonucleotide reductase; Region: RNR_III; cd01675 698968001125 effector binding site; other site 698968001126 active site 698968001127 Zn binding site [ion binding]; other site 698968001128 glycine loop; other site 698968001129 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 698968001130 S17 interaction site [polypeptide binding]; other site 698968001131 S8 interaction site; other site 698968001132 16S rRNA interaction site [nucleotide binding]; other site 698968001133 streptomycin interaction site [chemical binding]; other site 698968001134 23S rRNA interaction site [nucleotide binding]; other site 698968001135 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 698968001136 30S ribosomal protein S7; Validated; Region: PRK05302 698968001137 elongation factor G; Reviewed; Region: PRK00007 698968001138 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 698968001139 G1 box; other site 698968001140 putative GEF interaction site [polypeptide binding]; other site 698968001141 GTP/Mg2+ binding site [chemical binding]; other site 698968001142 Switch I region; other site 698968001143 G2 box; other site 698968001144 G3 box; other site 698968001145 Switch II region; other site 698968001146 G4 box; other site 698968001147 G5 box; other site 698968001148 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 698968001149 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 698968001150 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 698968001151 elongation factor Tu; Reviewed; Region: PRK00049 698968001152 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 698968001153 G1 box; other site 698968001154 GEF interaction site [polypeptide binding]; other site 698968001155 GTP/Mg2+ binding site [chemical binding]; other site 698968001156 Switch I region; other site 698968001157 G2 box; other site 698968001158 G3 box; other site 698968001159 Switch II region; other site 698968001160 G4 box; other site 698968001161 G5 box; other site 698968001162 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 698968001163 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 698968001164 Antibiotic Binding Site [chemical binding]; other site 698968001165 Predicted membrane protein [Function unknown]; Region: COG2323 698968001166 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 698968001167 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 698968001168 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 698968001169 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 698968001170 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 698968001171 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 698968001172 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 698968001173 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 698968001174 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 698968001175 putative translocon binding site; other site 698968001176 protein-rRNA interface [nucleotide binding]; other site 698968001177 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 698968001178 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 698968001179 G-X-X-G motif; other site 698968001180 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 698968001181 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 698968001182 23S rRNA interface [nucleotide binding]; other site 698968001183 5S rRNA interface [nucleotide binding]; other site 698968001184 putative antibiotic binding site [chemical binding]; other site 698968001185 L25 interface [polypeptide binding]; other site 698968001186 L27 interface [polypeptide binding]; other site 698968001187 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 698968001188 putative translocon interaction site; other site 698968001189 23S rRNA interface [nucleotide binding]; other site 698968001190 signal recognition particle (SRP54) interaction site; other site 698968001191 L23 interface [polypeptide binding]; other site 698968001192 trigger factor interaction site; other site 698968001193 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 698968001194 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698968001195 HlyD family secretion protein; Region: HlyD_3; pfam13437 698968001196 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698968001197 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698968001198 Walker A/P-loop; other site 698968001199 ATP binding site [chemical binding]; other site 698968001200 Q-loop/lid; other site 698968001201 ABC transporter signature motif; other site 698968001202 Walker B; other site 698968001203 D-loop; other site 698968001204 H-loop/switch region; other site 698968001205 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698968001206 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698968001207 FtsX-like permease family; Region: FtsX; pfam02687 698968001208 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 698968001209 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 698968001210 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 698968001211 RNA binding site [nucleotide binding]; other site 698968001212 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 698968001213 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 698968001214 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 698968001215 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 698968001216 serine transporter; Region: stp; TIGR00814 698968001217 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698968001218 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698968001219 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698968001220 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698968001221 active site 698968001222 homotetramer interface [polypeptide binding]; other site 698968001223 homodimer interface [polypeptide binding]; other site 698968001224 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 698968001225 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698968001226 ATP binding site [chemical binding]; other site 698968001227 substrate interface [chemical binding]; other site 698968001228 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698968001229 active site residue [active] 698968001230 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698968001231 MPT binding site; other site 698968001232 trimer interface [polypeptide binding]; other site 698968001233 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 698968001234 MoaE homodimer interface [polypeptide binding]; other site 698968001235 MoaD interaction [polypeptide binding]; other site 698968001236 active site residues [active] 698968001237 Predicted transcriptional regulator [Transcription]; Region: COG2345 698968001238 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 698968001239 DNA binding residues [nucleotide binding] 698968001240 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698968001241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968001242 dimer interface [polypeptide binding]; other site 698968001243 conserved gate region; other site 698968001244 putative PBP binding loops; other site 698968001245 ABC-ATPase subunit interface; other site 698968001246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968001247 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 698968001248 Walker A/P-loop; other site 698968001249 ATP binding site [chemical binding]; other site 698968001250 Q-loop/lid; other site 698968001251 ABC transporter signature motif; other site 698968001252 Walker B; other site 698968001253 D-loop; other site 698968001254 H-loop/switch region; other site 698968001255 TOBE domain; Region: TOBE; cl01440 698968001256 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 698968001257 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698968001258 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 698968001259 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 698968001260 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 698968001261 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 698968001262 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 698968001263 [4Fe-4S] binding site [ion binding]; other site 698968001264 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698968001265 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698968001266 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698968001267 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 698968001268 molybdopterin cofactor binding site; other site 698968001269 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 698968001270 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 698968001271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968001272 putative substrate translocation pore; other site 698968001273 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698968001274 MPT binding site; other site 698968001275 trimer interface [polypeptide binding]; other site 698968001276 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 698968001277 GTP binding site; other site 698968001278 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 698968001279 trimer interface [polypeptide binding]; other site 698968001280 dimer interface [polypeptide binding]; other site 698968001281 putative active site [active] 698968001282 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698968001283 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698968001284 dimer interface [polypeptide binding]; other site 698968001285 putative functional site; other site 698968001286 putative MPT binding site; other site 698968001287 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 698968001288 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698968001289 FeS/SAM binding site; other site 698968001290 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 698968001291 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698968001292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698968001293 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698968001294 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698968001295 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698968001296 inhibitor site; inhibition site 698968001297 active site 698968001298 dimer interface [polypeptide binding]; other site 698968001299 catalytic residue [active] 698968001300 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698968001301 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698968001302 Walker A/P-loop; other site 698968001303 ATP binding site [chemical binding]; other site 698968001304 Q-loop/lid; other site 698968001305 ABC transporter signature motif; other site 698968001306 Walker B; other site 698968001307 D-loop; other site 698968001308 H-loop/switch region; other site 698968001309 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698968001310 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698968001311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968001312 dimer interface [polypeptide binding]; other site 698968001313 conserved gate region; other site 698968001314 putative PBP binding loops; other site 698968001315 ABC-ATPase subunit interface; other site 698968001316 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698968001317 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698968001318 Walker A/P-loop; other site 698968001319 ATP binding site [chemical binding]; other site 698968001320 Q-loop/lid; other site 698968001321 ABC transporter signature motif; other site 698968001322 Walker B; other site 698968001323 D-loop; other site 698968001324 H-loop/switch region; other site 698968001325 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698968001326 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698968001327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968001328 dimer interface [polypeptide binding]; other site 698968001329 conserved gate region; other site 698968001330 putative PBP binding loops; other site 698968001331 ABC-ATPase subunit interface; other site 698968001332 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 698968001333 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698968001334 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698968001335 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698968001336 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698968001337 DNA-binding site [nucleotide binding]; DNA binding site 698968001338 FCD domain; Region: FCD; pfam07729 698968001339 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698968001340 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698968001341 nucleotide binding site [chemical binding]; other site 698968001342 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 698968001343 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 698968001344 putative active site cavity [active] 698968001345 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 698968001346 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 698968001347 active site 698968001348 dimer interface [polypeptide binding]; other site 698968001349 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698968001350 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 698968001351 active site 698968001352 trimer interface [polypeptide binding]; other site 698968001353 allosteric site; other site 698968001354 active site lid [active] 698968001355 hexamer (dimer of trimers) interface [polypeptide binding]; other site 698968001356 Htaa; Region: HtaA; pfam04213 698968001357 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 698968001358 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 698968001359 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698968001360 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698968001361 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 698968001362 5S rRNA interface [nucleotide binding]; other site 698968001363 L27 interface [polypeptide binding]; other site 698968001364 23S rRNA interface [nucleotide binding]; other site 698968001365 L5 interface [polypeptide binding]; other site 698968001366 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 698968001367 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 698968001368 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 698968001369 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 698968001370 23S rRNA binding site [nucleotide binding]; other site 698968001371 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 698968001372 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 698968001373 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 698968001374 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 698968001375 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698968001376 active site 698968001377 catalytic site [active] 698968001378 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698968001379 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698968001380 active site 698968001381 catalytic site [active] 698968001382 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 698968001383 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698968001384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968001385 dimer interface [polypeptide binding]; other site 698968001386 conserved gate region; other site 698968001387 putative PBP binding loops; other site 698968001388 ABC-ATPase subunit interface; other site 698968001389 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698968001390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968001391 dimer interface [polypeptide binding]; other site 698968001392 conserved gate region; other site 698968001393 putative PBP binding loops; other site 698968001394 ABC-ATPase subunit interface; other site 698968001395 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 698968001396 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698968001397 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698968001398 Walker A/P-loop; other site 698968001399 ATP binding site [chemical binding]; other site 698968001400 Q-loop/lid; other site 698968001401 ABC transporter signature motif; other site 698968001402 Walker B; other site 698968001403 D-loop; other site 698968001404 H-loop/switch region; other site 698968001405 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 698968001406 SecY translocase; Region: SecY; pfam00344 698968001407 adenylate kinase; Reviewed; Region: adk; PRK00279 698968001408 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 698968001409 AMP-binding site [chemical binding]; other site 698968001410 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 698968001411 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698968001412 active site 698968001413 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698968001414 catalytic site [active] 698968001415 BNR repeat-like domain; Region: BNR_2; pfam13088 698968001416 Asp-box motif; other site 698968001417 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698968001418 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 698968001419 rRNA binding site [nucleotide binding]; other site 698968001420 predicted 30S ribosome binding site; other site 698968001421 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 698968001422 30S ribosomal protein S13; Region: bact_S13; TIGR03631 698968001423 30S ribosomal protein S11; Validated; Region: PRK05309 698968001424 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 698968001425 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 698968001426 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698968001427 RNA binding surface [nucleotide binding]; other site 698968001428 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 698968001429 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 698968001430 alphaNTD - beta interaction site [polypeptide binding]; other site 698968001431 alphaNTD homodimer interface [polypeptide binding]; other site 698968001432 alphaNTD - beta' interaction site [polypeptide binding]; other site 698968001433 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 698968001434 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 698968001435 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 698968001436 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 698968001437 dimerization interface 3.5A [polypeptide binding]; other site 698968001438 active site 698968001439 Protein of unknown function (DUF690); Region: DUF690; cl04939 698968001440 TIGR02611 family protein; Region: TIGR02611 698968001441 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 698968001442 active site 698968001443 catalytic residues [active] 698968001444 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 698968001445 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 698968001446 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698968001447 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 698968001448 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698968001449 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698968001450 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 698968001451 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 698968001452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 698968001453 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 698968001454 23S rRNA interface [nucleotide binding]; other site 698968001455 L3 interface [polypeptide binding]; other site 698968001456 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 698968001457 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 698968001458 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 698968001459 active site 698968001460 substrate binding site [chemical binding]; other site 698968001461 metal binding site [ion binding]; metal-binding site 698968001462 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 698968001463 alanine racemase; Reviewed; Region: alr; PRK00053 698968001464 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 698968001465 active site 698968001466 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698968001467 dimer interface [polypeptide binding]; other site 698968001468 substrate binding site [chemical binding]; other site 698968001469 catalytic residues [active] 698968001470 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 698968001471 Predicted permease [General function prediction only]; Region: COG2985 698968001472 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698968001473 TrkA-C domain; Region: TrkA_C; pfam02080 698968001474 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698968001475 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698968001476 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 698968001477 Glycoprotease family; Region: Peptidase_M22; pfam00814 698968001478 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698968001479 Coenzyme A binding pocket [chemical binding]; other site 698968001480 UGMP family protein; Validated; Region: PRK09604 698968001481 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 698968001482 oligomerisation interface [polypeptide binding]; other site 698968001483 mobile loop; other site 698968001484 roof hairpin; other site 698968001485 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698968001486 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698968001487 ring oligomerisation interface [polypeptide binding]; other site 698968001488 ATP/Mg binding site [chemical binding]; other site 698968001489 stacking interactions; other site 698968001490 hinge regions; other site 698968001491 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 698968001492 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698968001493 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698968001494 DNA binding residues [nucleotide binding] 698968001495 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 698968001496 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698968001497 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 698968001498 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 698968001499 active site 698968001500 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 698968001501 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698968001502 phosphate binding site [ion binding]; other site 698968001503 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698968001504 siderophore binding site; other site 698968001505 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698968001506 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698968001507 dimer interface [polypeptide binding]; other site 698968001508 putative PBP binding regions; other site 698968001509 ABC-ATPase subunit interface; other site 698968001510 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698968001511 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698968001512 ABC-ATPase subunit interface; other site 698968001513 dimer interface [polypeptide binding]; other site 698968001514 putative PBP binding regions; other site 698968001515 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698968001516 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698968001517 Walker A/P-loop; other site 698968001518 ATP binding site [chemical binding]; other site 698968001519 Q-loop/lid; other site 698968001520 ABC transporter signature motif; other site 698968001521 Walker B; other site 698968001522 D-loop; other site 698968001523 H-loop/switch region; other site 698968001524 IucA / IucC family; Region: IucA_IucC; pfam04183 698968001525 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698968001526 IucA / IucC family; Region: IucA_IucC; pfam04183 698968001527 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698968001528 H+ Antiporter protein; Region: 2A0121; TIGR00900 698968001529 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 698968001530 EamA-like transporter family; Region: EamA; pfam00892 698968001531 GMP synthase; Reviewed; Region: guaA; PRK00074 698968001532 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 698968001533 AMP/PPi binding site [chemical binding]; other site 698968001534 candidate oxyanion hole; other site 698968001535 catalytic triad [active] 698968001536 potential glutamine specificity residues [chemical binding]; other site 698968001537 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 698968001538 ATP Binding subdomain [chemical binding]; other site 698968001539 Ligand Binding sites [chemical binding]; other site 698968001540 Dimerization subdomain; other site 698968001541 PspC domain; Region: PspC; pfam04024 698968001542 PspC domain; Region: PspC; pfam04024 698968001543 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698968001544 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698968001545 ATP binding site [chemical binding]; other site 698968001546 Mg2+ binding site [ion binding]; other site 698968001547 G-X-G motif; other site 698968001548 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698968001549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968001550 active site 698968001551 phosphorylation site [posttranslational modification] 698968001552 intermolecular recognition site; other site 698968001553 dimerization interface [polypeptide binding]; other site 698968001554 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698968001555 DNA binding residues [nucleotide binding] 698968001556 dimerization interface [polypeptide binding]; other site 698968001557 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698968001558 intersubunit interface [polypeptide binding]; other site 698968001559 DNA Polymerase Y-family; Region: PolY_like; cd03468 698968001560 active site 698968001561 DNA binding site [nucleotide binding] 698968001562 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 698968001563 putative dimer interface [polypeptide binding]; other site 698968001564 putative [2Fe-2S] cluster binding site [ion binding]; other site 698968001565 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698968001566 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698968001567 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698968001568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968001569 dimer interface [polypeptide binding]; other site 698968001570 conserved gate region; other site 698968001571 ABC-ATPase subunit interface; other site 698968001572 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 698968001573 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 698968001574 Walker A/P-loop; other site 698968001575 ATP binding site [chemical binding]; other site 698968001576 Q-loop/lid; other site 698968001577 ABC transporter signature motif; other site 698968001578 Walker B; other site 698968001579 D-loop; other site 698968001580 H-loop/switch region; other site 698968001581 NIL domain; Region: NIL; cl09633 698968001582 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698968001583 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 698968001584 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698968001585 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 698968001586 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 698968001587 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 698968001588 active site 698968001589 PHP Thumb interface [polypeptide binding]; other site 698968001590 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698968001591 generic binding surface II; other site 698968001592 generic binding surface I; other site 698968001593 Uncharacterized conserved protein [Function unknown]; Region: COG3402 698968001594 Predicted membrane protein [Function unknown]; Region: COG3428 698968001595 Bacterial PH domain; Region: DUF304; pfam03703 698968001596 Bacterial PH domain; Region: DUF304; pfam03703 698968001597 Bacterial PH domain; Region: DUF304; pfam03703 698968001598 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698968001599 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698968001600 intersubunit interface [polypeptide binding]; other site 698968001601 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698968001602 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698968001603 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698968001604 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698968001605 dimer interface [polypeptide binding]; other site 698968001606 putative PBP binding regions; other site 698968001607 ABC-ATPase subunit interface; other site 698968001608 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698968001609 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698968001610 ABC-ATPase subunit interface; other site 698968001611 dimer interface [polypeptide binding]; other site 698968001612 putative PBP binding regions; other site 698968001613 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698968001614 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698968001615 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698968001616 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 698968001617 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 698968001618 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 698968001619 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 698968001620 homodimer interface [polypeptide binding]; other site 698968001621 NADP binding site [chemical binding]; other site 698968001622 substrate binding site [chemical binding]; other site 698968001623 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 698968001624 Homeodomain-like domain; Region: HTH_23; cl17451 698968001625 Helix-turn-helix domain; Region: HTH_28; pfam13518 698968001626 putative transposase OrfB; Reviewed; Region: PHA02517 698968001627 HTH-like domain; Region: HTH_21; pfam13276 698968001628 Integrase core domain; Region: rve; pfam00665 698968001629 Integrase core domain; Region: rve_2; pfam13333 698968001630 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 698968001631 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698968001632 active site 698968001633 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 698968001634 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 698968001635 Htaa; Region: HtaA; pfam04213 698968001636 Htaa; Region: HtaA; pfam04213 698968001637 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698968001638 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698968001639 intersubunit interface [polypeptide binding]; other site 698968001640 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698968001641 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698968001642 ABC-ATPase subunit interface; other site 698968001643 dimer interface [polypeptide binding]; other site 698968001644 putative PBP binding regions; other site 698968001645 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 698968001646 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698968001647 Walker A/P-loop; other site 698968001648 ATP binding site [chemical binding]; other site 698968001649 Q-loop/lid; other site 698968001650 ABC transporter signature motif; other site 698968001651 Walker B; other site 698968001652 D-loop; other site 698968001653 H-loop/switch region; other site 698968001654 Htaa; Region: HtaA; pfam04213 698968001655 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 698968001656 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698968001657 homodimer interface [polypeptide binding]; other site 698968001658 substrate-cofactor binding pocket; other site 698968001659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968001660 catalytic residue [active] 698968001661 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 698968001662 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 698968001663 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698968001664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968001665 putative substrate translocation pore; other site 698968001666 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698968001667 putative catalytic site [active] 698968001668 putative metal binding site [ion binding]; other site 698968001669 putative phosphate binding site [ion binding]; other site 698968001670 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 698968001671 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 698968001672 active site 698968001673 HIGH motif; other site 698968001674 dimer interface [polypeptide binding]; other site 698968001675 KMSKS motif; other site 698968001676 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 698968001677 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698968001678 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698968001679 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698968001680 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698968001681 NlpC/P60 family; Region: NLPC_P60; pfam00877 698968001682 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698968001683 active site 698968001684 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698968001685 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698968001686 non-specific DNA binding site [nucleotide binding]; other site 698968001687 salt bridge; other site 698968001688 sequence-specific DNA binding site [nucleotide binding]; other site 698968001689 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698968001690 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 698968001691 metal binding site [ion binding]; metal-binding site 698968001692 putative dimer interface [polypeptide binding]; other site 698968001693 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 698968001694 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698968001695 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698968001696 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698968001697 pyruvate carboxylase; Reviewed; Region: PRK12999 698968001698 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698968001699 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698968001700 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698968001701 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698968001702 active site 698968001703 catalytic residues [active] 698968001704 metal binding site [ion binding]; metal-binding site 698968001705 homodimer binding site [polypeptide binding]; other site 698968001706 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698968001707 carboxyltransferase (CT) interaction site; other site 698968001708 biotinylation site [posttranslational modification]; other site 698968001709 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 698968001710 ADP-ribose binding site [chemical binding]; other site 698968001711 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 698968001712 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698968001713 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 698968001714 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698968001715 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698968001716 carboxyltransferase (CT) interaction site; other site 698968001717 biotinylation site [posttranslational modification]; other site 698968001718 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698968001719 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698968001720 active site residue [active] 698968001721 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698968001722 active site residue [active] 698968001723 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698968001724 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 698968001725 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 698968001726 active site 698968001727 dimer interface [polypeptide binding]; other site 698968001728 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 698968001729 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698968001730 substrate binding site [chemical binding]; other site 698968001731 dimer interface [polypeptide binding]; other site 698968001732 ATP binding site [chemical binding]; other site 698968001733 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698968001734 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698968001735 DNA binding site [nucleotide binding] 698968001736 domain linker motif; other site 698968001737 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 698968001738 dimerization interface [polypeptide binding]; other site 698968001739 putative ligand binding site [chemical binding]; other site 698968001740 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 698968001741 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698968001742 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698968001743 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698968001744 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698968001745 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698968001746 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698968001747 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 698968001748 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 698968001749 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 698968001750 ATP-grasp domain; Region: ATP-grasp; pfam02222 698968001751 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 698968001752 Uncharacterized conserved protein [Function unknown]; Region: COG1434 698968001753 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698968001754 putative active site [active] 698968001755 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 698968001756 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 698968001757 HupF/HypC family; Region: HupF_HypC; pfam01455 698968001758 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 698968001759 dimerization interface [polypeptide binding]; other site 698968001760 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 698968001761 ATP binding site [chemical binding]; other site 698968001762 Acylphosphatase; Region: Acylphosphatase; pfam00708 698968001763 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 698968001764 HypF finger; Region: zf-HYPF; pfam07503 698968001765 HypF finger; Region: zf-HYPF; pfam07503 698968001766 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 698968001767 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 698968001768 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698968001769 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 698968001770 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 698968001771 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 698968001772 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 698968001773 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 698968001774 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 698968001775 putative substrate-binding site; other site 698968001776 nickel binding site [ion binding]; other site 698968001777 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 698968001778 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 698968001779 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 698968001780 TIGR03089 family protein; Region: TIGR03089 698968001781 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698968001782 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698968001783 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698968001784 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698968001785 active site 698968001786 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698968001787 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 698968001788 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 698968001789 active site 698968001790 Substrate binding site; other site 698968001791 Mg++ binding site; other site 698968001792 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698968001793 putative trimer interface [polypeptide binding]; other site 698968001794 putative CoA binding site [chemical binding]; other site 698968001795 Transcription factor WhiB; Region: Whib; pfam02467 698968001796 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 698968001797 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 698968001798 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 698968001799 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 698968001800 active site 698968001801 substrate binding site [chemical binding]; other site 698968001802 metal binding site [ion binding]; metal-binding site 698968001803 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 698968001804 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698968001805 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698968001806 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 698968001807 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 698968001808 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 698968001809 homotetramer interface [polypeptide binding]; other site 698968001810 ligand binding site [chemical binding]; other site 698968001811 catalytic site [active] 698968001812 NAD binding site [chemical binding]; other site 698968001813 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 698968001814 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 698968001815 TMP-binding site; other site 698968001816 ATP-binding site [chemical binding]; other site 698968001817 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698968001818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968001819 active site 698968001820 phosphorylation site [posttranslational modification] 698968001821 intermolecular recognition site; other site 698968001822 dimerization interface [polypeptide binding]; other site 698968001823 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698968001824 DNA binding site [nucleotide binding] 698968001825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698968001826 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698968001827 dimerization interface [polypeptide binding]; other site 698968001828 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698968001829 dimer interface [polypeptide binding]; other site 698968001830 phosphorylation site [posttranslational modification] 698968001831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698968001832 ATP binding site [chemical binding]; other site 698968001833 Mg2+ binding site [ion binding]; other site 698968001834 G-X-G motif; other site 698968001835 lipoprotein LpqB; Provisional; Region: PRK13616 698968001836 Sporulation and spore germination; Region: Germane; pfam10646 698968001837 comF family protein; Region: comF; TIGR00201 698968001838 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698968001839 active site 698968001840 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 698968001841 30S subunit binding site; other site 698968001842 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 698968001843 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698968001844 ATP binding site [chemical binding]; other site 698968001845 putative Mg++ binding site [ion binding]; other site 698968001846 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 698968001847 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968001848 nucleotide binding region [chemical binding]; other site 698968001849 ATP-binding site [chemical binding]; other site 698968001850 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 698968001851 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 698968001852 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698968001853 FAD binding pocket [chemical binding]; other site 698968001854 FAD binding motif [chemical binding]; other site 698968001855 phosphate binding motif [ion binding]; other site 698968001856 beta-alpha-beta structure motif; other site 698968001857 NAD binding pocket [chemical binding]; other site 698968001858 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698968001859 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 698968001860 catalytic loop [active] 698968001861 iron binding site [ion binding]; other site 698968001862 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 698968001863 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 698968001864 putative di-iron ligands [ion binding]; other site 698968001865 Predicted GTPases [General function prediction only]; Region: COG1162 698968001866 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 698968001867 GTPase/Zn-binding domain interface [polypeptide binding]; other site 698968001868 GTP/Mg2+ binding site [chemical binding]; other site 698968001869 G4 box; other site 698968001870 G5 box; other site 698968001871 G1 box; other site 698968001872 Switch I region; other site 698968001873 G2 box; other site 698968001874 G3 box; other site 698968001875 Switch II region; other site 698968001876 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 698968001877 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 698968001878 hinge; other site 698968001879 active site 698968001880 Uncharacterized conserved protein [Function unknown]; Region: COG2135 698968001881 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 698968001882 putative deacylase active site [active] 698968001883 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 698968001884 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698968001885 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698968001886 DNA binding residues [nucleotide binding] 698968001887 Transcription factor WhiB; Region: Whib; pfam02467 698968001888 PQQ-like domain; Region: PQQ_2; pfam13360 698968001889 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698968001890 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698968001891 ATP binding site [chemical binding]; other site 698968001892 putative Mg++ binding site [ion binding]; other site 698968001893 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968001894 nucleotide binding region [chemical binding]; other site 698968001895 ATP-binding site [chemical binding]; other site 698968001896 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 698968001897 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 698968001898 TIGR02569 family protein; Region: TIGR02569_actnb 698968001899 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698968001900 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698968001901 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698968001902 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698968001903 Part of AAA domain; Region: AAA_19; pfam13245 698968001904 Family description; Region: UvrD_C_2; pfam13538 698968001905 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698968001906 Ion channel; Region: Ion_trans_2; pfam07885 698968001907 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 698968001908 TrkA-N domain; Region: TrkA_N; pfam02254 698968001909 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 698968001910 putative NADH binding site [chemical binding]; other site 698968001911 putative active site [active] 698968001912 nudix motif; other site 698968001913 putative metal binding site [ion binding]; other site 698968001914 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 698968001915 Part of AAA domain; Region: AAA_19; pfam13245 698968001916 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698968001917 Family description; Region: UvrD_C_2; pfam13538 698968001918 HRDC domain; Region: HRDC; pfam00570 698968001919 Protein of unknown function DUF45; Region: DUF45; pfam01863 698968001920 putative hydrolase; Region: TIGR03624 698968001921 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 698968001922 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698968001923 hypothetical protein; Validated; Region: PRK00068 698968001924 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 698968001925 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698968001926 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 698968001927 active site 698968001928 Protein of unknown function (DUF418); Region: DUF418; cl12135 698968001929 oxaloacetate decarboxylase; Provisional; Region: PRK12330 698968001930 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698968001931 active site 698968001932 catalytic residues [active] 698968001933 metal binding site [ion binding]; metal-binding site 698968001934 homodimer binding site [polypeptide binding]; other site 698968001935 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 698968001936 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698968001937 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698968001938 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698968001939 carboxyltransferase (CT) interaction site; other site 698968001940 biotinylation site [posttranslational modification]; other site 698968001941 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698968001942 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 698968001943 active site 698968001944 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698968001945 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698968001946 active site 698968001947 peptide chain release factor 2; Validated; Region: prfB; PRK00578 698968001948 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698968001949 RF-1 domain; Region: RF-1; pfam00472 698968001950 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 698968001951 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 698968001952 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698968001953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968001954 Walker A/P-loop; other site 698968001955 ATP binding site [chemical binding]; other site 698968001956 Q-loop/lid; other site 698968001957 ABC transporter signature motif; other site 698968001958 Walker B; other site 698968001959 D-loop; other site 698968001960 H-loop/switch region; other site 698968001961 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 698968001962 FtsX-like permease family; Region: FtsX; pfam02687 698968001963 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 698968001964 SmpB-tmRNA interface; other site 698968001965 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698968001966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698968001967 HTH-like domain; Region: HTH_21; pfam13276 698968001968 Integrase core domain; Region: rve; pfam00665 698968001969 Integrase core domain; Region: rve_2; pfam13333 698968001970 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698968001971 MULE transposase domain; Region: MULE; pfam10551 698968001972 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 698968001973 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 698968001974 active site 698968001975 zinc binding site [ion binding]; other site 698968001976 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39F; cd02425 698968001977 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 698968001978 putative active site [active] 698968001979 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698968001980 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 698968001981 Walker A/P-loop; other site 698968001982 ATP binding site [chemical binding]; other site 698968001983 Q-loop/lid; other site 698968001984 ABC transporter signature motif; other site 698968001985 Walker B; other site 698968001986 D-loop; other site 698968001987 H-loop/switch region; other site 698968001988 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698968001989 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698968001990 Walker A/P-loop; other site 698968001991 ATP binding site [chemical binding]; other site 698968001992 Q-loop/lid; other site 698968001993 ABC transporter signature motif; other site 698968001994 Walker B; other site 698968001995 D-loop; other site 698968001996 H-loop/switch region; other site 698968001997 Integrase core domain; Region: rve_3; pfam13683 698968001998 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698968001999 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698968002000 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 698968002001 DNA-binding interface [nucleotide binding]; DNA binding site 698968002002 HTH-like domain; Region: HTH_21; pfam13276 698968002003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698968002004 Integrase core domain; Region: rve; pfam00665 698968002005 Integrase core domain; Region: rve_3; pfam13683 698968002006 Cupin domain; Region: Cupin_2; cl17218 698968002007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968002008 S-adenosylmethionine binding site [chemical binding]; other site 698968002009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698968002010 Integrase core domain; Region: rve_3; cl15866 698968002011 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698968002012 Helix-turn-helix domain; Region: HTH_38; pfam13936 698968002013 Integrase core domain; Region: rve; pfam00665 698968002014 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698968002015 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698968002016 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 698968002017 Bacterial PH domain; Region: DUF304; cl01348 698968002018 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 698968002019 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698968002020 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698968002021 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968002022 nucleotide binding region [chemical binding]; other site 698968002023 ATP-binding site [chemical binding]; other site 698968002024 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698968002025 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698968002026 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 698968002027 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698968002028 DNA-binding site [nucleotide binding]; DNA binding site 698968002029 RNA-binding motif; other site 698968002030 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 698968002031 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 698968002032 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 698968002033 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 698968002034 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698968002035 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698968002036 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 698968002037 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698968002038 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698968002039 catalytic residue [active] 698968002040 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 698968002041 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 698968002042 dimer interface [polypeptide binding]; other site 698968002043 active site 698968002044 citrylCoA binding site [chemical binding]; other site 698968002045 NADH binding [chemical binding]; other site 698968002046 cationic pore residues; other site 698968002047 oxalacetate/citrate binding site [chemical binding]; other site 698968002048 coenzyme A binding site [chemical binding]; other site 698968002049 catalytic triad [active] 698968002050 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698968002051 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 698968002052 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698968002053 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698968002054 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698968002055 active site 698968002056 catalytic tetrad [active] 698968002057 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 698968002058 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698968002059 substrate binding site [chemical binding]; other site 698968002060 oxyanion hole (OAH) forming residues; other site 698968002061 trimer interface [polypeptide binding]; other site 698968002062 Protein of unknown function, DUF485; Region: DUF485; pfam04341 698968002063 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698968002064 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 698968002065 Na binding site [ion binding]; other site 698968002066 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 698968002067 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 698968002068 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698968002069 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 698968002070 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 698968002071 active site 698968002072 SAM binding site [chemical binding]; other site 698968002073 homodimer interface [polypeptide binding]; other site 698968002074 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698968002075 catalytic residues [active] 698968002076 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 698968002077 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 698968002078 folate binding site [chemical binding]; other site 698968002079 NADP+ binding site [chemical binding]; other site 698968002080 thymidylate synthase; Reviewed; Region: thyA; PRK01827 698968002081 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 698968002082 dimerization interface [polypeptide binding]; other site 698968002083 active site 698968002084 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 698968002085 active site 698968002086 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968002087 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 698968002088 ATP binding site [chemical binding]; other site 698968002089 putative Mg++ binding site [ion binding]; other site 698968002090 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968002091 nucleotide binding region [chemical binding]; other site 698968002092 ATP-binding site [chemical binding]; other site 698968002093 DEAD/H associated; Region: DEAD_assoc; pfam08494 698968002094 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 698968002095 active site 698968002096 SUMO-1 interface [polypeptide binding]; other site 698968002097 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698968002098 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 698968002099 putative DNA binding site [nucleotide binding]; other site 698968002100 catalytic residue [active] 698968002101 putative H2TH interface [polypeptide binding]; other site 698968002102 putative catalytic residues [active] 698968002103 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698968002104 Predicted permease [General function prediction only]; Region: COG2985 698968002105 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698968002106 TrkA-C domain; Region: TrkA_C; pfam02080 698968002107 TrkA-C domain; Region: TrkA_C; pfam02080 698968002108 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698968002109 hypothetical protein; Provisional; Region: PRK11770 698968002110 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698968002111 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698968002112 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 698968002113 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 698968002114 active site 698968002115 dimer interface [polypeptide binding]; other site 698968002116 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 698968002117 dimer interface [polypeptide binding]; other site 698968002118 active site 698968002119 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698968002120 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698968002121 tetramerization interface [polypeptide binding]; other site 698968002122 NAD(P) binding site [chemical binding]; other site 698968002123 catalytic residues [active] 698968002124 hypothetical protein; Provisional; Region: PRK07857 698968002125 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 698968002126 Part of AAA domain; Region: AAA_19; pfam13245 698968002127 Family description; Region: UvrD_C_2; pfam13538 698968002128 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698968002129 Peptidase family M23; Region: Peptidase_M23; pfam01551 698968002130 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 698968002131 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 698968002132 active site 698968002133 substrate binding site [chemical binding]; other site 698968002134 cosubstrate binding site; other site 698968002135 catalytic site [active] 698968002136 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 698968002137 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 698968002138 purine monophosphate binding site [chemical binding]; other site 698968002139 dimer interface [polypeptide binding]; other site 698968002140 putative catalytic residues [active] 698968002141 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 698968002142 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698968002143 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 698968002144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698968002145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698968002146 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 698968002147 30S ribosomal protein S18; Provisional; Region: PRK13401 698968002148 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 698968002149 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 698968002150 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 698968002151 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 698968002152 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 698968002153 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698968002154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968002155 active site 698968002156 phosphorylation site [posttranslational modification] 698968002157 intermolecular recognition site; other site 698968002158 dimerization interface [polypeptide binding]; other site 698968002159 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698968002160 DNA binding site [nucleotide binding] 698968002161 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698968002162 dimerization interface [polypeptide binding]; other site 698968002163 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698968002164 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698968002165 dimer interface [polypeptide binding]; other site 698968002166 phosphorylation site [posttranslational modification] 698968002167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698968002168 ATP binding site [chemical binding]; other site 698968002169 Mg2+ binding site [ion binding]; other site 698968002170 G-X-G motif; other site 698968002171 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698968002172 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698968002173 protein binding site [polypeptide binding]; other site 698968002174 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698968002175 MPT binding site; other site 698968002176 trimer interface [polypeptide binding]; other site 698968002177 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 698968002178 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 698968002179 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 698968002180 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 698968002181 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 698968002182 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 698968002183 active site 698968002184 tetramer interface; other site 698968002185 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698968002186 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698968002187 dimer interface [polypeptide binding]; other site 698968002188 putative functional site; other site 698968002189 putative MPT binding site; other site 698968002190 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698968002191 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698968002192 Predicted membrane protein [Function unknown]; Region: COG2259 698968002193 Predicted integral membrane protein [Function unknown]; Region: COG5660 698968002194 Putative zinc-finger; Region: zf-HC2; pfam13490 698968002195 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 698968002196 BCCT family transporter; Region: BCCT; pfam02028 698968002197 Uncharacterized membrane protein [Function unknown]; Region: COG3949 698968002198 Predicted methyltransferases [General function prediction only]; Region: COG0313 698968002199 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 698968002200 putative SAM binding site [chemical binding]; other site 698968002201 putative homodimer interface [polypeptide binding]; other site 698968002202 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 698968002203 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 698968002204 active site 698968002205 HIGH motif; other site 698968002206 KMSKS motif; other site 698968002207 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 698968002208 tRNA binding surface [nucleotide binding]; other site 698968002209 anticodon binding site; other site 698968002210 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 698968002211 active site 698968002212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 698968002213 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698968002214 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698968002215 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698968002216 G5 domain; Region: G5; pfam07501 698968002217 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698968002218 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 698968002219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968002220 S-adenosylmethionine binding site [chemical binding]; other site 698968002221 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 698968002222 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698968002223 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698968002224 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698968002225 ABC transporter; Region: ABC_tran_2; pfam12848 698968002226 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698968002227 Uncharacterized conserved protein [Function unknown]; Region: COG1359 698968002228 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698968002229 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698968002230 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698968002231 DNA binding residues [nucleotide binding] 698968002232 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698968002233 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 698968002234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968002235 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698968002236 active site 698968002237 motif I; other site 698968002238 motif II; other site 698968002239 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698968002240 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 698968002241 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698968002242 substrate binding site [chemical binding]; other site 698968002243 oxyanion hole (OAH) forming residues; other site 698968002244 trimer interface [polypeptide binding]; other site 698968002245 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 698968002246 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698968002247 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698968002248 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 698968002249 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 698968002250 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698968002251 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 698968002252 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 698968002253 G1 box; other site 698968002254 putative GEF interaction site [polypeptide binding]; other site 698968002255 GTP/Mg2+ binding site [chemical binding]; other site 698968002256 Switch I region; other site 698968002257 G2 box; other site 698968002258 G3 box; other site 698968002259 Switch II region; other site 698968002260 G4 box; other site 698968002261 G5 box; other site 698968002262 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 698968002263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968002264 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 698968002265 NAD(P) binding site [chemical binding]; other site 698968002266 active site 698968002267 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698968002268 putative active site [active] 698968002269 catalytic residue [active] 698968002270 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698968002271 active site 698968002272 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698968002273 putative active site [active] 698968002274 catalytic residue [active] 698968002275 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 698968002276 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 698968002277 5S rRNA interface [nucleotide binding]; other site 698968002278 CTC domain interface [polypeptide binding]; other site 698968002279 L16 interface [polypeptide binding]; other site 698968002280 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 698968002281 Ca binding site [ion binding]; other site 698968002282 active site 698968002283 catalytic site [active] 698968002284 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 698968002285 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 698968002286 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 698968002287 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698968002288 active site 698968002289 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 698968002290 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 698968002291 Substrate binding site; other site 698968002292 Mg++ binding site; other site 698968002293 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 698968002294 active site 698968002295 substrate binding site [chemical binding]; other site 698968002296 CoA binding site [chemical binding]; other site 698968002297 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698968002298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698968002299 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 698968002300 putative dimerization interface [polypeptide binding]; other site 698968002301 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 698968002302 gating phenylalanine in ion channel; other site 698968002303 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698968002304 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 698968002305 putative ligand binding site [chemical binding]; other site 698968002306 putative NAD binding site [chemical binding]; other site 698968002307 catalytic site [active] 698968002308 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698968002309 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698968002310 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968002311 Q-loop/lid; other site 698968002312 ABC transporter signature motif; other site 698968002313 Walker B; other site 698968002314 D-loop; other site 698968002315 H-loop/switch region; other site 698968002316 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698968002317 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698968002318 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968002319 Walker A/P-loop; other site 698968002320 ATP binding site [chemical binding]; other site 698968002321 Q-loop/lid; other site 698968002322 ABC transporter signature motif; other site 698968002323 Walker B; other site 698968002324 D-loop; other site 698968002325 H-loop/switch region; other site 698968002326 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698968002327 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698968002328 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 698968002329 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 698968002330 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968002331 ATP binding site [chemical binding]; other site 698968002332 putative Mg++ binding site [ion binding]; other site 698968002333 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968002334 nucleotide binding region [chemical binding]; other site 698968002335 ATP-binding site [chemical binding]; other site 698968002336 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 698968002337 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 698968002338 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 698968002339 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698968002340 enolase; Provisional; Region: eno; PRK00077 698968002341 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 698968002342 dimer interface [polypeptide binding]; other site 698968002343 metal binding site [ion binding]; metal-binding site 698968002344 substrate binding pocket [chemical binding]; other site 698968002345 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 698968002346 Septum formation initiator; Region: DivIC; pfam04977 698968002347 Uncharacterized conserved protein [Function unknown]; Region: COG1507 698968002348 exopolyphosphatase; Region: exo_poly_only; TIGR03706 698968002349 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698968002350 Helix-turn-helix domain; Region: HTH_18; pfam12833 698968002351 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698968002352 Bax inhibitor 1 like; Region: BaxI_1; cl17691 698968002353 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 698968002354 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 698968002355 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 698968002356 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 698968002357 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 698968002358 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 698968002359 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698968002360 catalytic residue [active] 698968002361 putative FPP diphosphate binding site; other site 698968002362 putative FPP binding hydrophobic cleft; other site 698968002363 dimer interface [polypeptide binding]; other site 698968002364 putative IPP diphosphate binding site; other site 698968002365 Flavodoxin domain; Region: Flavodoxin_5; cl17428 698968002366 pantothenate kinase; Provisional; Region: PRK05439 698968002367 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 698968002368 ATP-binding site [chemical binding]; other site 698968002369 CoA-binding site [chemical binding]; other site 698968002370 Mg2+-binding site [ion binding]; other site 698968002371 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 698968002372 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 698968002373 dimer interface [polypeptide binding]; other site 698968002374 active site 698968002375 glycine-pyridoxal phosphate binding site [chemical binding]; other site 698968002376 folate binding site [chemical binding]; other site 698968002377 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698968002378 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 698968002379 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698968002380 Coenzyme A binding pocket [chemical binding]; other site 698968002381 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698968002382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968002383 putative substrate translocation pore; other site 698968002384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968002385 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698968002386 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698968002387 fumarate hydratase; Reviewed; Region: fumC; PRK00485 698968002388 Class II fumarases; Region: Fumarase_classII; cd01362 698968002389 active site 698968002390 tetramer interface [polypeptide binding]; other site 698968002391 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 698968002392 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 698968002393 putative active site [active] 698968002394 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 698968002395 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 698968002396 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 698968002397 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 698968002398 generic binding surface II; other site 698968002399 generic binding surface I; other site 698968002400 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 698968002401 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 698968002402 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698968002403 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698968002404 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 698968002405 Na2 binding site [ion binding]; other site 698968002406 putative substrate binding site 1 [chemical binding]; other site 698968002407 Na binding site 1 [ion binding]; other site 698968002408 putative substrate binding site 2 [chemical binding]; other site 698968002409 GTP-binding protein YchF; Reviewed; Region: PRK09601 698968002410 YchF GTPase; Region: YchF; cd01900 698968002411 G1 box; other site 698968002412 GTP/Mg2+ binding site [chemical binding]; other site 698968002413 Switch I region; other site 698968002414 G2 box; other site 698968002415 Switch II region; other site 698968002416 G3 box; other site 698968002417 G4 box; other site 698968002418 G5 box; other site 698968002419 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 698968002420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 698968002421 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 698968002422 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 698968002423 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 698968002424 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 698968002425 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 698968002426 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 698968002427 Cl- selectivity filter; other site 698968002428 Cl- binding residues [ion binding]; other site 698968002429 pore gating glutamate residue; other site 698968002430 dimer interface [polypeptide binding]; other site 698968002431 Homeodomain-like domain; Region: HTH_23; cl17451 698968002432 Helix-turn-helix domain; Region: HTH_28; pfam13518 698968002433 putative transposase OrfB; Reviewed; Region: PHA02517 698968002434 HTH-like domain; Region: HTH_21; pfam13276 698968002435 Integrase core domain; Region: rve; pfam00665 698968002436 Integrase core domain; Region: rve_2; pfam13333 698968002437 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698968002438 Walker A/P-loop; other site 698968002439 ATP binding site [chemical binding]; other site 698968002440 ABC transporter; Region: ABC_tran; pfam00005 698968002441 Q-loop/lid; other site 698968002442 ABC transporter signature motif; other site 698968002443 Walker B; other site 698968002444 D-loop; other site 698968002445 H-loop/switch region; other site 698968002446 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 698968002447 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698968002448 Walker A/P-loop; other site 698968002449 ATP binding site [chemical binding]; other site 698968002450 Q-loop/lid; other site 698968002451 ABC transporter signature motif; other site 698968002452 Walker B; other site 698968002453 D-loop; other site 698968002454 H-loop/switch region; other site 698968002455 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698968002456 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 698968002457 active site 698968002458 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698968002459 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698968002460 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698968002461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968002462 dimer interface [polypeptide binding]; other site 698968002463 conserved gate region; other site 698968002464 putative PBP binding loops; other site 698968002465 ABC-ATPase subunit interface; other site 698968002466 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698968002467 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698968002468 Walker A/P-loop; other site 698968002469 ATP binding site [chemical binding]; other site 698968002470 Q-loop/lid; other site 698968002471 ABC transporter signature motif; other site 698968002472 Walker B; other site 698968002473 D-loop; other site 698968002474 H-loop/switch region; other site 698968002475 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698968002476 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698968002477 Walker A/P-loop; other site 698968002478 ATP binding site [chemical binding]; other site 698968002479 Q-loop/lid; other site 698968002480 ABC transporter signature motif; other site 698968002481 Walker B; other site 698968002482 D-loop; other site 698968002483 H-loop/switch region; other site 698968002484 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698968002485 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698968002486 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968002487 Walker A/P-loop; other site 698968002488 ATP binding site [chemical binding]; other site 698968002489 Q-loop/lid; other site 698968002490 ABC transporter signature motif; other site 698968002491 Walker B; other site 698968002492 D-loop; other site 698968002493 H-loop/switch region; other site 698968002494 Trypsin; Region: Trypsin; pfam00089 698968002495 active site 698968002496 substrate binding sites [chemical binding]; other site 698968002497 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 698968002498 ArsC family; Region: ArsC; pfam03960 698968002499 catalytic residues [active] 698968002500 Protein of unknown function (DUF402); Region: DUF402; cl00979 698968002501 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 698968002502 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 698968002503 G1 box; other site 698968002504 GTP/Mg2+ binding site [chemical binding]; other site 698968002505 G2 box; other site 698968002506 Switch I region; other site 698968002507 G3 box; other site 698968002508 Switch II region; other site 698968002509 G4 box; other site 698968002510 G5 box; other site 698968002511 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 698968002512 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 698968002513 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 698968002514 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698968002515 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 698968002516 Ferredoxin [Energy production and conversion]; Region: COG1146 698968002517 4Fe-4S binding domain; Region: Fer4; pfam00037 698968002518 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 698968002519 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698968002520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968002521 homodimer interface [polypeptide binding]; other site 698968002522 catalytic residue [active] 698968002523 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698968002524 active site 698968002525 Predicted membrane protein [Function unknown]; Region: COG2246 698968002526 GtrA-like protein; Region: GtrA; pfam04138 698968002527 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698968002528 active site 698968002529 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 698968002530 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698968002531 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 698968002532 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 698968002533 putative trimer interface [polypeptide binding]; other site 698968002534 putative CoA binding site [chemical binding]; other site 698968002535 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 698968002536 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698968002537 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 698968002538 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698968002539 putative trimer interface [polypeptide binding]; other site 698968002540 putative CoA binding site [chemical binding]; other site 698968002541 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 698968002542 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 698968002543 metal binding site [ion binding]; metal-binding site 698968002544 putative dimer interface [polypeptide binding]; other site 698968002545 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698968002546 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698968002547 dihydropteroate synthase; Region: DHPS; TIGR01496 698968002548 substrate binding pocket [chemical binding]; other site 698968002549 dimer interface [polypeptide binding]; other site 698968002550 inhibitor binding site; inhibition site 698968002551 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 698968002552 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 698968002553 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 698968002554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968002555 S-adenosylmethionine binding site [chemical binding]; other site 698968002556 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 698968002557 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 698968002558 active site 698968002559 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 698968002560 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 698968002561 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 698968002562 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698968002563 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 698968002564 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 698968002565 ligand binding site; other site 698968002566 oligomer interface; other site 698968002567 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 698968002568 dimer interface [polypeptide binding]; other site 698968002569 N-terminal domain interface [polypeptide binding]; other site 698968002570 sulfate 1 binding site; other site 698968002571 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 698968002572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698968002573 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 698968002574 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698968002575 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698968002576 DNA binding residues [nucleotide binding] 698968002577 Putative zinc-finger; Region: zf-HC2; pfam13490 698968002578 sec-independent translocase; Provisional; Region: tatB; PRK00182 698968002579 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 698968002580 Domain of unknown function DUF59; Region: DUF59; pfam01883 698968002581 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 698968002582 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 698968002583 Predicted membrane protein [Function unknown]; Region: COG4420 698968002584 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 698968002585 MgtE intracellular N domain; Region: MgtE_N; smart00924 698968002586 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 698968002587 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 698968002588 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698968002589 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 698968002590 TPP-binding site [chemical binding]; other site 698968002591 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 698968002592 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698968002593 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698968002594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968002595 Walker A/P-loop; other site 698968002596 ATP binding site [chemical binding]; other site 698968002597 Q-loop/lid; other site 698968002598 ABC transporter signature motif; other site 698968002599 Walker B; other site 698968002600 D-loop; other site 698968002601 H-loop/switch region; other site 698968002602 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698968002603 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698968002604 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968002605 Walker A/P-loop; other site 698968002606 ATP binding site [chemical binding]; other site 698968002607 Q-loop/lid; other site 698968002608 ABC transporter signature motif; other site 698968002609 Walker B; other site 698968002610 D-loop; other site 698968002611 H-loop/switch region; other site 698968002612 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 698968002613 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698968002614 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698968002615 shikimate binding site; other site 698968002616 NAD(P) binding site [chemical binding]; other site 698968002617 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698968002618 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698968002619 catalytic triad [active] 698968002620 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 698968002621 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 698968002622 active site 698968002623 catalytic residues [active] 698968002624 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 698968002625 putative transporter; Provisional; Region: PRK10484 698968002626 Na binding site [ion binding]; other site 698968002627 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698968002628 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 698968002629 nucleotide binding site/active site [active] 698968002630 HIT family signature motif; other site 698968002631 catalytic residue [active] 698968002632 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 698968002633 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698968002634 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698968002635 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698968002636 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 698968002637 PLD-like domain; Region: PLDc_2; pfam13091 698968002638 putative homodimer interface [polypeptide binding]; other site 698968002639 putative active site [active] 698968002640 catalytic site [active] 698968002641 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698968002642 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 698968002643 putative Mg++ binding site [ion binding]; other site 698968002644 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968002645 nucleotide binding region [chemical binding]; other site 698968002646 ATP-binding site [chemical binding]; other site 698968002647 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 698968002648 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 698968002649 active site 698968002650 8-oxo-dGMP binding site [chemical binding]; other site 698968002651 nudix motif; other site 698968002652 metal binding site [ion binding]; metal-binding site 698968002653 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 698968002654 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698968002655 ATP binding site [chemical binding]; other site 698968002656 Mg++ binding site [ion binding]; other site 698968002657 motif III; other site 698968002658 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968002659 nucleotide binding region [chemical binding]; other site 698968002660 ATP-binding site [chemical binding]; other site 698968002661 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 698968002662 putative RNA binding site [nucleotide binding]; other site 698968002663 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698968002664 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698968002665 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 698968002666 Na binding site [ion binding]; other site 698968002667 SNF2 Helicase protein; Region: DUF3670; pfam12419 698968002668 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 698968002669 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968002670 ATP binding site [chemical binding]; other site 698968002671 putative Mg++ binding site [ion binding]; other site 698968002672 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968002673 nucleotide binding region [chemical binding]; other site 698968002674 ATP-binding site [chemical binding]; other site 698968002675 Uncharacterized conserved protein [Function unknown]; Region: COG4279 698968002676 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 698968002677 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 698968002678 active site 698968002679 metal binding site [ion binding]; metal-binding site 698968002680 DNA binding site [nucleotide binding] 698968002681 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 698968002682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968002683 Walker A/P-loop; other site 698968002684 ATP binding site [chemical binding]; other site 698968002685 Q-loop/lid; other site 698968002686 Uncharacterized conserved protein [Function unknown]; Region: COG2353 698968002687 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698968002688 MarR family; Region: MarR_2; pfam12802 698968002689 PspC domain; Region: PspC; cl00864 698968002690 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698968002691 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 698968002692 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698968002693 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 698968002694 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698968002695 Cysteine-rich domain; Region: CCG; pfam02754 698968002696 Cysteine-rich domain; Region: CCG; pfam02754 698968002697 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698968002698 L-lactate permease; Region: Lactate_perm; cl00701 698968002699 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 698968002700 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 698968002701 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 698968002702 active site 698968002703 HIGH motif; other site 698968002704 KMSK motif region; other site 698968002705 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 698968002706 tRNA binding surface [nucleotide binding]; other site 698968002707 anticodon binding site; other site 698968002708 diaminopimelate decarboxylase; Region: lysA; TIGR01048 698968002709 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 698968002710 active site 698968002711 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698968002712 substrate binding site [chemical binding]; other site 698968002713 catalytic residues [active] 698968002714 dimer interface [polypeptide binding]; other site 698968002715 homoserine dehydrogenase; Provisional; Region: PRK06349 698968002716 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 698968002717 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 698968002718 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 698968002719 homoserine kinase; Provisional; Region: PRK01212 698968002720 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 698968002721 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698968002722 acyl-activating enzyme (AAE) consensus motif; other site 698968002723 AMP binding site [chemical binding]; other site 698968002724 active site 698968002725 CoA binding site [chemical binding]; other site 698968002726 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 698968002727 transcription termination factor Rho; Provisional; Region: PRK12608 698968002728 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698968002729 RNA binding site [nucleotide binding]; other site 698968002730 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 698968002731 multimer interface [polypeptide binding]; other site 698968002732 Walker A motif; other site 698968002733 ATP binding site [chemical binding]; other site 698968002734 Walker B motif; other site 698968002735 peptide chain release factor 1; Validated; Region: prfA; PRK00591 698968002736 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698968002737 RF-1 domain; Region: RF-1; pfam00472 698968002738 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 698968002739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968002740 S-adenosylmethionine binding site [chemical binding]; other site 698968002741 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 698968002742 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 698968002743 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 698968002744 Mg++ binding site [ion binding]; other site 698968002745 putative catalytic motif [active] 698968002746 substrate binding site [chemical binding]; other site 698968002747 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 698968002748 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 698968002749 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 698968002750 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 698968002751 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 698968002752 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 698968002753 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 698968002754 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 698968002755 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698968002756 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 698968002757 beta subunit interaction interface [polypeptide binding]; other site 698968002758 Walker A motif; other site 698968002759 ATP binding site [chemical binding]; other site 698968002760 Walker B motif; other site 698968002761 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698968002762 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 698968002763 core domain interface [polypeptide binding]; other site 698968002764 delta subunit interface [polypeptide binding]; other site 698968002765 epsilon subunit interface [polypeptide binding]; other site 698968002766 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 698968002767 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698968002768 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 698968002769 alpha subunit interaction interface [polypeptide binding]; other site 698968002770 Walker A motif; other site 698968002771 ATP binding site [chemical binding]; other site 698968002772 Walker B motif; other site 698968002773 inhibitor binding site; inhibition site 698968002774 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698968002775 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 698968002776 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 698968002777 gamma subunit interface [polypeptide binding]; other site 698968002778 epsilon subunit interface [polypeptide binding]; other site 698968002779 LBP interface [polypeptide binding]; other site 698968002780 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 698968002781 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 698968002782 hypothetical protein; Provisional; Region: PRK03298 698968002783 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 698968002784 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698968002785 dimer interface [polypeptide binding]; other site 698968002786 substrate binding site [chemical binding]; other site 698968002787 metal binding site [ion binding]; metal-binding site 698968002788 Domain of unknown function DUF77; Region: DUF77; pfam01910 698968002789 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698968002790 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698968002791 Walker A/P-loop; other site 698968002792 ATP binding site [chemical binding]; other site 698968002793 Q-loop/lid; other site 698968002794 ABC transporter signature motif; other site 698968002795 Walker B; other site 698968002796 D-loop; other site 698968002797 H-loop/switch region; other site 698968002798 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698968002799 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698968002800 ABC-ATPase subunit interface; other site 698968002801 dimer interface [polypeptide binding]; other site 698968002802 putative PBP binding regions; other site 698968002803 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698968002804 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698968002805 ABC-ATPase subunit interface; other site 698968002806 dimer interface [polypeptide binding]; other site 698968002807 putative PBP binding regions; other site 698968002808 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698968002809 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698968002810 siderophore binding site; other site 698968002811 TIGR02611 family protein; Region: TIGR02611 698968002812 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 698968002813 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 698968002814 PsiA protein; Region: PsiA; cl11646 698968002815 glycogen branching enzyme; Provisional; Region: PRK05402 698968002816 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 698968002817 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 698968002818 active site 698968002819 catalytic site [active] 698968002820 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 698968002821 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 698968002822 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 698968002823 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698968002824 active site 698968002825 homodimer interface [polypeptide binding]; other site 698968002826 catalytic site [active] 698968002827 acceptor binding site [chemical binding]; other site 698968002828 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698968002829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968002830 Walker A/P-loop; other site 698968002831 ATP binding site [chemical binding]; other site 698968002832 Q-loop/lid; other site 698968002833 ABC transporter signature motif; other site 698968002834 Walker B; other site 698968002835 D-loop; other site 698968002836 H-loop/switch region; other site 698968002837 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 698968002838 Ligand binding site [chemical binding]; other site 698968002839 Electron transfer flavoprotein domain; Region: ETF; pfam01012 698968002840 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 698968002841 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 698968002842 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 698968002843 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 698968002844 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 698968002845 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698968002846 catalytic residue [active] 698968002847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968002848 S-adenosylmethionine binding site [chemical binding]; other site 698968002849 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 698968002850 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 698968002851 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698968002852 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698968002853 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698968002854 active site 698968002855 catalytic site [active] 698968002856 substrate binding site [chemical binding]; other site 698968002857 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 698968002858 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 698968002859 nucleotide binding pocket [chemical binding]; other site 698968002860 K-X-D-G motif; other site 698968002861 catalytic site [active] 698968002862 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 698968002863 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 698968002864 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 698968002865 Dimer interface [polypeptide binding]; other site 698968002866 BRCT sequence motif; other site 698968002867 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698968002868 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 698968002869 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698968002870 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 698968002871 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 698968002872 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698968002873 Coenzyme A binding pocket [chemical binding]; other site 698968002874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968002875 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698968002876 putative substrate translocation pore; other site 698968002877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968002878 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698968002879 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698968002880 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698968002881 ABC-ATPase subunit interface; other site 698968002882 dimer interface [polypeptide binding]; other site 698968002883 putative PBP binding regions; other site 698968002884 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698968002885 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968002886 Walker A/P-loop; other site 698968002887 ATP binding site [chemical binding]; other site 698968002888 Q-loop/lid; other site 698968002889 ABC transporter signature motif; other site 698968002890 Walker B; other site 698968002891 D-loop; other site 698968002892 H-loop/switch region; other site 698968002893 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 698968002894 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 698968002895 putative ligand binding residues [chemical binding]; other site 698968002896 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 698968002897 phosphofructokinase; Region: PFK_mixed; TIGR02483 698968002898 active site 698968002899 ADP/pyrophosphate binding site [chemical binding]; other site 698968002900 dimerization interface [polypeptide binding]; other site 698968002901 allosteric effector site; other site 698968002902 fructose-1,6-bisphosphate binding site; other site 698968002903 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 698968002904 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 698968002905 GatB domain; Region: GatB_Yqey; smart00845 698968002906 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698968002907 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698968002908 active site 698968002909 catalytic tetrad [active] 698968002910 Lysine efflux permease [General function prediction only]; Region: COG1279 698968002911 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 698968002912 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698968002913 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698968002914 dimerization interface [polypeptide binding]; other site 698968002915 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 698968002916 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 698968002917 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 698968002918 putative dimer interface [polypeptide binding]; other site 698968002919 N-terminal domain interface [polypeptide binding]; other site 698968002920 putative substrate binding pocket (H-site) [chemical binding]; other site 698968002921 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698968002922 Predicted membrane protein [Function unknown]; Region: COG2259 698968002923 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 698968002924 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698968002925 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 698968002926 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698968002927 PYR/PP interface [polypeptide binding]; other site 698968002928 dimer interface [polypeptide binding]; other site 698968002929 TPP binding site [chemical binding]; other site 698968002930 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698968002931 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 698968002932 TPP-binding site [chemical binding]; other site 698968002933 dimer interface [polypeptide binding]; other site 698968002934 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 698968002935 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 698968002936 putative valine binding site [chemical binding]; other site 698968002937 dimer interface [polypeptide binding]; other site 698968002938 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 698968002939 ketol-acid reductoisomerase; Provisional; Region: PRK05479 698968002940 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 698968002941 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 698968002942 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 698968002943 Uncharacterized conserved protein [Function unknown]; Region: COG1479 698968002944 Protein of unknown function DUF262; Region: DUF262; pfam03235 698968002945 Uncharacterized conserved protein [Function unknown]; Region: COG3472 698968002946 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 698968002947 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 698968002948 ligand binding site [chemical binding]; other site 698968002949 NAD binding site [chemical binding]; other site 698968002950 dimerization interface [polypeptide binding]; other site 698968002951 catalytic site [active] 698968002952 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 698968002953 putative L-serine binding site [chemical binding]; other site 698968002954 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 698968002955 tartrate dehydrogenase; Region: TTC; TIGR02089 698968002956 potential frameshift: common BLAST hit: gi|62390174|ref|YP_225576.1| signal transduction protein 698968002957 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698968002958 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698968002959 ligand binding site [chemical binding]; other site 698968002960 flexible hinge region; other site 698968002961 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698968002962 FOG: CBS domain [General function prediction only]; Region: COG0517 698968002963 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 698968002964 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698968002965 metal binding triad; other site 698968002966 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 698968002967 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698968002968 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698968002969 catalytic site [active] 698968002970 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 698968002971 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 698968002972 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 698968002973 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698968002974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968002975 S-adenosylmethionine binding site [chemical binding]; other site 698968002976 isochorismate synthase DhbC; Validated; Region: PRK06923 698968002977 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698968002978 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 698968002979 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698968002980 active site 698968002981 HIGH motif; other site 698968002982 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698968002983 active site 698968002984 KMSKS motif; other site 698968002985 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 698968002986 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 698968002987 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 698968002988 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 698968002989 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 698968002990 PhnA protein; Region: PhnA; pfam03831 698968002991 biotin synthase; Region: bioB; TIGR00433 698968002992 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698968002993 FeS/SAM binding site; other site 698968002994 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698968002995 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698968002996 HD domain; Region: HD_4; pfam13328 698968002997 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698968002998 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698968002999 putative DNA binding site [nucleotide binding]; other site 698968003000 putative Zn2+ binding site [ion binding]; other site 698968003001 Bacterial transcriptional regulator; Region: IclR; pfam01614 698968003002 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 698968003003 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 698968003004 substrate binding site [chemical binding]; other site 698968003005 ligand binding site [chemical binding]; other site 698968003006 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 698968003007 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 698968003008 substrate binding site [chemical binding]; other site 698968003009 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698968003010 active site 698968003011 Ap6A binding site [chemical binding]; other site 698968003012 nudix motif; other site 698968003013 metal binding site [ion binding]; metal-binding site 698968003014 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698968003015 catalytic core [active] 698968003016 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 698968003017 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698968003018 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 698968003019 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 698968003020 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 698968003021 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698968003022 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698968003023 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698968003024 thiamine monophosphate kinase; Provisional; Region: PRK05731 698968003025 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 698968003026 ATP binding site [chemical binding]; other site 698968003027 dimerization interface [polypeptide binding]; other site 698968003028 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 698968003029 ligand binding site [chemical binding]; other site 698968003030 active site 698968003031 UGI interface [polypeptide binding]; other site 698968003032 catalytic site [active] 698968003033 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 698968003034 DAK2 domain; Region: Dak2; pfam02734 698968003035 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 698968003036 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 698968003037 generic binding surface II; other site 698968003038 ssDNA binding site; other site 698968003039 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968003040 ATP binding site [chemical binding]; other site 698968003041 putative Mg++ binding site [ion binding]; other site 698968003042 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968003043 nucleotide binding region [chemical binding]; other site 698968003044 ATP-binding site [chemical binding]; other site 698968003045 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 698968003046 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698968003047 carboxyltransferase (CT) interaction site; other site 698968003048 biotinylation site [posttranslational modification]; other site 698968003049 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 698968003050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968003051 S-adenosylmethionine binding site [chemical binding]; other site 698968003052 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 698968003053 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 698968003054 active site 698968003055 (T/H)XGH motif; other site 698968003056 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698968003057 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698968003058 Walker A/P-loop; other site 698968003059 ATP binding site [chemical binding]; other site 698968003060 Q-loop/lid; other site 698968003061 ABC transporter signature motif; other site 698968003062 Walker B; other site 698968003063 D-loop; other site 698968003064 H-loop/switch region; other site 698968003065 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698968003066 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698968003067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968003068 dimer interface [polypeptide binding]; other site 698968003069 conserved gate region; other site 698968003070 putative PBP binding loops; other site 698968003071 ABC-ATPase subunit interface; other site 698968003072 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698968003073 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698968003074 substrate binding pocket [chemical binding]; other site 698968003075 membrane-bound complex binding site; other site 698968003076 hinge residues; other site 698968003077 Domain of unknown function (DUF368); Region: DUF368; pfam04018 698968003078 DNA polymerase I; Provisional; Region: PRK05755 698968003079 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 698968003080 active site 698968003081 metal binding site 1 [ion binding]; metal-binding site 698968003082 putative 5' ssDNA interaction site; other site 698968003083 metal binding site 3; metal-binding site 698968003084 metal binding site 2 [ion binding]; metal-binding site 698968003085 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 698968003086 putative DNA binding site [nucleotide binding]; other site 698968003087 putative metal binding site [ion binding]; other site 698968003088 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 698968003089 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 698968003090 active site 698968003091 DNA binding site [nucleotide binding] 698968003092 catalytic site [active] 698968003093 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698968003094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968003095 S-adenosylmethionine binding site [chemical binding]; other site 698968003096 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 698968003097 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 698968003098 RNA binding site [nucleotide binding]; other site 698968003099 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 698968003100 RNA binding site [nucleotide binding]; other site 698968003101 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698968003102 RNA binding site [nucleotide binding]; other site 698968003103 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 698968003104 RNA binding site [nucleotide binding]; other site 698968003105 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 698968003106 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 698968003107 transcriptional antiterminator BglG; Provisional; Region: PRK09772 698968003108 CAT RNA binding domain; Region: CAT_RBD; smart01061 698968003109 PRD domain; Region: PRD; pfam00874 698968003110 PRD domain; Region: PRD; pfam00874 698968003111 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 698968003112 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698968003113 active site turn [active] 698968003114 phosphorylation site [posttranslational modification] 698968003115 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698968003116 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 698968003117 HPr interaction site; other site 698968003118 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698968003119 active site 698968003120 phosphorylation site [posttranslational modification] 698968003121 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 698968003122 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 698968003123 CoA-binding site [chemical binding]; other site 698968003124 ATP-binding [chemical binding]; other site 698968003125 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 698968003126 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698968003127 FeS/SAM binding site; other site 698968003128 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 698968003129 excinuclease ABC subunit B; Provisional; Region: PRK05298 698968003130 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968003131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968003132 nucleotide binding region [chemical binding]; other site 698968003133 ATP-binding site [chemical binding]; other site 698968003134 Ultra-violet resistance protein B; Region: UvrB; pfam12344 698968003135 UvrB/uvrC motif; Region: UVR; pfam02151 698968003136 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698968003137 Ligand Binding Site [chemical binding]; other site 698968003138 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 698968003139 Part of AAA domain; Region: AAA_19; pfam13245 698968003140 PhoH-like protein; Region: PhoH; cl17668 698968003141 Family description; Region: UvrD_C_2; pfam13538 698968003142 Predicted membrane protein [Function unknown]; Region: COG2259 698968003143 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698968003144 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 698968003145 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698968003146 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698968003147 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 698968003148 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 698968003149 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 698968003150 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 698968003151 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 698968003152 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 698968003153 23S rRNA binding site [nucleotide binding]; other site 698968003154 L21 binding site [polypeptide binding]; other site 698968003155 L13 binding site [polypeptide binding]; other site 698968003156 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698968003157 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 698968003158 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698968003159 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 698968003160 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 698968003161 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 698968003162 dimer interface [polypeptide binding]; other site 698968003163 motif 1; other site 698968003164 active site 698968003165 motif 2; other site 698968003166 motif 3; other site 698968003167 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 698968003168 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 698968003169 putative tRNA-binding site [nucleotide binding]; other site 698968003170 B3/4 domain; Region: B3_4; pfam03483 698968003171 tRNA synthetase B5 domain; Region: B5; smart00874 698968003172 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 698968003173 dimer interface [polypeptide binding]; other site 698968003174 motif 1; other site 698968003175 motif 3; other site 698968003176 motif 2; other site 698968003177 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 698968003178 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 698968003179 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698968003180 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 698968003181 heterotetramer interface [polypeptide binding]; other site 698968003182 active site pocket [active] 698968003183 cleavage site 698968003184 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 698968003185 feedback inhibition sensing region; other site 698968003186 homohexameric interface [polypeptide binding]; other site 698968003187 nucleotide binding site [chemical binding]; other site 698968003188 N-acetyl-L-glutamate binding site [chemical binding]; other site 698968003189 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 698968003190 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698968003191 inhibitor-cofactor binding pocket; inhibition site 698968003192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968003193 catalytic residue [active] 698968003194 ornithine carbamoyltransferase; Provisional; Region: PRK00779 698968003195 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698968003196 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698968003197 arginine repressor; Provisional; Region: PRK03341 698968003198 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 698968003199 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 698968003200 argininosuccinate synthase; Provisional; Region: PRK13820 698968003201 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 698968003202 ANP binding site [chemical binding]; other site 698968003203 Substrate Binding Site II [chemical binding]; other site 698968003204 Substrate Binding Site I [chemical binding]; other site 698968003205 argininosuccinate lyase; Provisional; Region: PRK00855 698968003206 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 698968003207 active sites [active] 698968003208 tetramer interface [polypeptide binding]; other site 698968003209 Uncharacterized conserved protein [Function unknown]; Region: COG2835 698968003210 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 698968003211 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 698968003212 active site 698968003213 HIGH motif; other site 698968003214 dimer interface [polypeptide binding]; other site 698968003215 KMSKS motif; other site 698968003216 S4 RNA-binding domain; Region: S4; smart00363 698968003217 transcription termination factor Rho; Provisional; Region: PRK12678 698968003218 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698968003219 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968003220 active site 698968003221 motif I; other site 698968003222 motif II; other site 698968003223 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968003224 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 698968003225 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698968003226 RNA binding surface [nucleotide binding]; other site 698968003227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968003228 S-adenosylmethionine binding site [chemical binding]; other site 698968003229 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 698968003230 ATP-NAD kinase; Region: NAD_kinase; pfam01513 698968003231 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 698968003232 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698968003233 Walker A/P-loop; other site 698968003234 ATP binding site [chemical binding]; other site 698968003235 Q-loop/lid; other site 698968003236 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698968003237 ABC transporter signature motif; other site 698968003238 Walker B; other site 698968003239 D-loop; other site 698968003240 H-loop/switch region; other site 698968003241 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 698968003242 Thiamine pyrophosphokinase; Region: TPK; cl08415 698968003243 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 698968003244 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 698968003245 dimer interface [polypeptide binding]; other site 698968003246 ADP-ribose binding site [chemical binding]; other site 698968003247 active site 698968003248 nudix motif; other site 698968003249 metal binding site [ion binding]; metal-binding site 698968003250 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 698968003251 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 698968003252 active site 698968003253 Int/Topo IB signature motif; other site 698968003254 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698968003255 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698968003256 P-loop; other site 698968003257 Magnesium ion binding site [ion binding]; other site 698968003258 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698968003259 Magnesium ion binding site [ion binding]; other site 698968003260 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 698968003261 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698968003262 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 698968003263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968003264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968003265 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 698968003266 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698968003267 inhibitor-cofactor binding pocket; inhibition site 698968003268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968003269 catalytic residue [active] 698968003270 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698968003271 AAA domain; Region: AAA_26; pfam13500 698968003272 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 698968003273 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 698968003274 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698968003275 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698968003276 RNA binding surface [nucleotide binding]; other site 698968003277 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 698968003278 active site 698968003279 cytidylate kinase; Provisional; Region: cmk; PRK00023 698968003280 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 698968003281 CMP-binding site; other site 698968003282 The sites determining sugar specificity; other site 698968003283 GTP-binding protein Der; Reviewed; Region: PRK03003 698968003284 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 698968003285 G1 box; other site 698968003286 GTP/Mg2+ binding site [chemical binding]; other site 698968003287 Switch I region; other site 698968003288 G2 box; other site 698968003289 Switch II region; other site 698968003290 G3 box; other site 698968003291 G4 box; other site 698968003292 G5 box; other site 698968003293 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 698968003294 G1 box; other site 698968003295 GTP/Mg2+ binding site [chemical binding]; other site 698968003296 Switch I region; other site 698968003297 G2 box; other site 698968003298 G3 box; other site 698968003299 Switch II region; other site 698968003300 G4 box; other site 698968003301 G5 box; other site 698968003302 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698968003303 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 698968003304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968003305 S-adenosylmethionine binding site [chemical binding]; other site 698968003306 Putative esterase; Region: Esterase; pfam00756 698968003307 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698968003308 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 698968003309 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698968003310 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 698968003311 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968003312 nucleotide binding region [chemical binding]; other site 698968003313 ATP-binding site [chemical binding]; other site 698968003314 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698968003315 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698968003316 phosphopeptide binding site; other site 698968003317 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 698968003318 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698968003319 DNA binding residues [nucleotide binding] 698968003320 Bifunctional nuclease; Region: DNase-RNase; pfam02577 698968003321 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 698968003322 DNA binding residues [nucleotide binding] 698968003323 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698968003324 putative dimer interface [polypeptide binding]; other site 698968003325 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698968003326 metal ion-dependent adhesion site (MIDAS); other site 698968003327 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698968003328 Domain of unknown function DUF21; Region: DUF21; pfam01595 698968003329 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698968003330 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698968003331 Domain of unknown function DUF21; Region: DUF21; pfam01595 698968003332 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698968003333 Transporter associated domain; Region: CorC_HlyC; smart01091 698968003334 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 698968003335 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698968003336 ATP binding site [chemical binding]; other site 698968003337 Mg++ binding site [ion binding]; other site 698968003338 motif III; other site 698968003339 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968003340 nucleotide binding region [chemical binding]; other site 698968003341 ATP-binding site [chemical binding]; other site 698968003342 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698968003343 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 698968003344 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 698968003345 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 698968003346 CoenzymeA binding site [chemical binding]; other site 698968003347 subunit interaction site [polypeptide binding]; other site 698968003348 PHB binding site; other site 698968003349 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 698968003350 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 698968003351 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 698968003352 oligomer interface [polypeptide binding]; other site 698968003353 metal binding site [ion binding]; metal-binding site 698968003354 metal binding site [ion binding]; metal-binding site 698968003355 putative Cl binding site [ion binding]; other site 698968003356 basic sphincter; other site 698968003357 hydrophobic gate; other site 698968003358 periplasmic entrance; other site 698968003359 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698968003360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968003361 S-adenosylmethionine binding site [chemical binding]; other site 698968003362 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698968003363 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698968003364 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698968003365 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 698968003366 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698968003367 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 698968003368 potential frameshift: common BLAST hit: gi|227833113|ref|YP_002834820.1| oxidoreductase 698968003369 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698968003370 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698968003371 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 698968003372 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698968003373 FAD binding domain; Region: FAD_binding_4; pfam01565 698968003374 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698968003375 Sodium Bile acid symporter family; Region: SBF; pfam01758 698968003376 YceI-like domain; Region: YceI; pfam04264 698968003377 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 698968003378 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 698968003379 Ligand binding site; other site 698968003380 Putative Catalytic site; other site 698968003381 DXD motif; other site 698968003382 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 698968003383 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 698968003384 putative active site [active] 698968003385 catalytic triad [active] 698968003386 putative dimer interface [polypeptide binding]; other site 698968003387 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 698968003388 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 698968003389 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698968003390 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698968003391 precorrin-3B synthase; Region: CobG; TIGR02435 698968003392 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698968003393 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698968003394 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 698968003395 Precorrin-8X methylmutase; Region: CbiC; pfam02570 698968003396 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 698968003397 active site 698968003398 SAM binding site [chemical binding]; other site 698968003399 homodimer interface [polypeptide binding]; other site 698968003400 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 698968003401 active site 698968003402 SAM binding site [chemical binding]; other site 698968003403 homodimer interface [polypeptide binding]; other site 698968003404 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 698968003405 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 698968003406 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 698968003407 active site 698968003408 SAM binding site [chemical binding]; other site 698968003409 homodimer interface [polypeptide binding]; other site 698968003410 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 698968003411 active site 698968003412 putative homodimer interface [polypeptide binding]; other site 698968003413 SAM binding site [chemical binding]; other site 698968003414 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 698968003415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968003416 S-adenosylmethionine binding site [chemical binding]; other site 698968003417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968003418 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698968003419 NAD(P) binding site [chemical binding]; other site 698968003420 active site 698968003421 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698968003422 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698968003423 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698968003424 active site 698968003425 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698968003426 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968003427 ATP binding site [chemical binding]; other site 698968003428 putative Mg++ binding site [ion binding]; other site 698968003429 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968003430 nucleotide binding region [chemical binding]; other site 698968003431 ATP-binding site [chemical binding]; other site 698968003432 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 698968003433 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 698968003434 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 698968003435 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 698968003436 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 698968003437 Predicted transcriptional regulator [Transcription]; Region: COG2378 698968003438 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 698968003439 WYL domain; Region: WYL; pfam13280 698968003440 WYL domain; Region: WYL; pfam13280 698968003441 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 698968003442 Pup-like protein; Region: Pup; pfam05639 698968003443 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 698968003444 proteasome ATPase; Region: pup_AAA; TIGR03689 698968003445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968003446 Walker A motif; other site 698968003447 ATP binding site [chemical binding]; other site 698968003448 Walker B motif; other site 698968003449 arginine finger; other site 698968003450 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 698968003451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968003452 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 698968003453 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 698968003454 active site 698968003455 metal binding site [ion binding]; metal-binding site 698968003456 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 698968003457 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 698968003458 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 698968003459 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 698968003460 Potassium binding sites [ion binding]; other site 698968003461 Cesium cation binding sites [ion binding]; other site 698968003462 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 698968003463 Aspartase; Region: Aspartase; cd01357 698968003464 active sites [active] 698968003465 tetramer interface [polypeptide binding]; other site 698968003466 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698968003467 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 698968003468 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 698968003469 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 698968003470 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 698968003471 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 698968003472 homodimer interface [polypeptide binding]; other site 698968003473 putative metal binding site [ion binding]; other site 698968003474 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 698968003475 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968003476 motif II; other site 698968003477 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 698968003478 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 698968003479 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 698968003480 substrate binding pocket [chemical binding]; other site 698968003481 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 698968003482 B12 binding site [chemical binding]; other site 698968003483 cobalt ligand [ion binding]; other site 698968003484 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 698968003485 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 698968003486 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698968003487 active site 698968003488 HIGH motif; other site 698968003489 nucleotide binding site [chemical binding]; other site 698968003490 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698968003491 active site 698968003492 KMSKS motif; other site 698968003493 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698968003494 tRNA binding surface [nucleotide binding]; other site 698968003495 anticodon binding site; other site 698968003496 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 698968003497 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 698968003498 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 698968003499 quinone interaction residues [chemical binding]; other site 698968003500 active site 698968003501 catalytic residues [active] 698968003502 FMN binding site [chemical binding]; other site 698968003503 substrate binding site [chemical binding]; other site 698968003504 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 698968003505 substrate binding site [chemical binding]; other site 698968003506 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698968003507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698968003508 HTH-like domain; Region: HTH_21; pfam13276 698968003509 Integrase core domain; Region: rve; pfam00665 698968003510 Integrase core domain; Region: rve_2; pfam13333 698968003511 potential frameshift: common BLAST hit: gi|256379310|ref|YP_003102970.1| oxidoreductase 698968003512 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968003513 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698968003514 active site residue [active] 698968003515 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698968003516 active site residue [active] 698968003517 membrane ATPase/protein kinase; Provisional; Region: PRK09435 698968003518 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 698968003519 Walker A; other site 698968003520 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 698968003521 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 698968003522 active site 698968003523 substrate binding site [chemical binding]; other site 698968003524 coenzyme B12 binding site [chemical binding]; other site 698968003525 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 698968003526 B12 binding site [chemical binding]; other site 698968003527 cobalt ligand [ion binding]; other site 698968003528 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 698968003529 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 698968003530 heterodimer interface [polypeptide binding]; other site 698968003531 substrate interaction site [chemical binding]; other site 698968003532 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 698968003533 Uncharacterized conserved protein [Function unknown]; Region: COG0398 698968003534 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 698968003535 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 698968003536 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698968003537 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698968003538 MULE transposase domain; Region: MULE; pfam10551 698968003539 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 698968003540 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 698968003541 ferrochelatase; Reviewed; Region: hemH; PRK00035 698968003542 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 698968003543 C-terminal domain interface [polypeptide binding]; other site 698968003544 active site 698968003545 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 698968003546 active site 698968003547 N-terminal domain interface [polypeptide binding]; other site 698968003548 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698968003549 NlpC/P60 family; Region: NLPC_P60; pfam00877 698968003550 aconitate hydratase; Validated; Region: PRK09277 698968003551 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698968003552 substrate binding site [chemical binding]; other site 698968003553 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698968003554 ligand binding site [chemical binding]; other site 698968003555 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 698968003556 substrate binding site [chemical binding]; other site 698968003557 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698968003558 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698968003559 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 698968003560 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 698968003561 catalytic triad [active] 698968003562 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 698968003563 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 698968003564 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698968003565 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698968003566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968003567 Walker A/P-loop; other site 698968003568 ATP binding site [chemical binding]; other site 698968003569 Q-loop/lid; other site 698968003570 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698968003571 ABC transporter signature motif; other site 698968003572 Walker B; other site 698968003573 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698968003574 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 698968003575 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 698968003576 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 698968003577 trimerization site [polypeptide binding]; other site 698968003578 active site 698968003579 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698968003580 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 698968003581 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698968003582 catalytic residue [active] 698968003583 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 698968003584 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 698968003585 Walker A/P-loop; other site 698968003586 ATP binding site [chemical binding]; other site 698968003587 Q-loop/lid; other site 698968003588 ABC transporter signature motif; other site 698968003589 Walker B; other site 698968003590 D-loop; other site 698968003591 H-loop/switch region; other site 698968003592 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 698968003593 FeS assembly protein SufD; Region: sufD; TIGR01981 698968003594 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 698968003595 FeS assembly protein SufB; Region: sufB; TIGR01980 698968003596 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698968003597 Predicted transcriptional regulator [Transcription]; Region: COG2345 698968003598 putative DNA binding site [nucleotide binding]; other site 698968003599 putative Zn2+ binding site [ion binding]; other site 698968003600 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698968003601 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698968003602 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698968003603 Walker A/P-loop; other site 698968003604 ATP binding site [chemical binding]; other site 698968003605 Q-loop/lid; other site 698968003606 ABC transporter signature motif; other site 698968003607 Walker B; other site 698968003608 D-loop; other site 698968003609 H-loop/switch region; other site 698968003610 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698968003611 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698968003612 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 698968003613 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 698968003614 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 698968003615 UbiA prenyltransferase family; Region: UbiA; pfam01040 698968003616 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 698968003617 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 698968003618 TPP-binding site [chemical binding]; other site 698968003619 dimer interface [polypeptide binding]; other site 698968003620 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698968003621 PYR/PP interface [polypeptide binding]; other site 698968003622 dimer interface [polypeptide binding]; other site 698968003623 TPP binding site [chemical binding]; other site 698968003624 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698968003625 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 698968003626 putative active site [active] 698968003627 transaldolase; Provisional; Region: PRK03903 698968003628 catalytic residue [active] 698968003629 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 698968003630 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 698968003631 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 698968003632 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 698968003633 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 698968003634 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698968003635 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 698968003636 putative active site [active] 698968003637 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 698968003638 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 698968003639 triosephosphate isomerase; Provisional; Region: PRK14567 698968003640 substrate binding site [chemical binding]; other site 698968003641 dimer interface [polypeptide binding]; other site 698968003642 catalytic triad [active] 698968003643 Phosphoglycerate kinase; Region: PGK; pfam00162 698968003644 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 698968003645 substrate binding site [chemical binding]; other site 698968003646 hinge regions; other site 698968003647 ADP binding site [chemical binding]; other site 698968003648 catalytic site [active] 698968003649 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 698968003650 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 698968003651 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698968003652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 698968003653 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 698968003654 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 698968003655 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 698968003656 phosphate binding site [ion binding]; other site 698968003657 putative substrate binding pocket [chemical binding]; other site 698968003658 dimer interface [polypeptide binding]; other site 698968003659 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 698968003660 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 698968003661 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 698968003662 GIY-YIG motif/motif A; other site 698968003663 active site 698968003664 catalytic site [active] 698968003665 putative DNA binding site [nucleotide binding]; other site 698968003666 metal binding site [ion binding]; metal-binding site 698968003667 UvrB/uvrC motif; Region: UVR; pfam02151 698968003668 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 698968003669 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698968003670 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 698968003671 homopentamer interface [polypeptide binding]; other site 698968003672 active site 698968003673 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 698968003674 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 698968003675 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 698968003676 dimerization interface [polypeptide binding]; other site 698968003677 active site 698968003678 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 698968003679 Lumazine binding domain; Region: Lum_binding; pfam00677 698968003680 Lumazine binding domain; Region: Lum_binding; pfam00677 698968003681 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 698968003682 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 698968003683 catalytic motif [active] 698968003684 Zn binding site [ion binding]; other site 698968003685 RibD C-terminal domain; Region: RibD_C; pfam01872 698968003686 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 698968003687 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 698968003688 substrate binding site [chemical binding]; other site 698968003689 hexamer interface [polypeptide binding]; other site 698968003690 metal binding site [ion binding]; metal-binding site 698968003691 16S rRNA methyltransferase B; Provisional; Region: PRK14902 698968003692 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 698968003693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968003694 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 698968003695 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 698968003696 putative active site [active] 698968003697 substrate binding site [chemical binding]; other site 698968003698 putative cosubstrate binding site; other site 698968003699 catalytic site [active] 698968003700 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 698968003701 substrate binding site [chemical binding]; other site 698968003702 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698968003703 active site 698968003704 catalytic residues [active] 698968003705 metal binding site [ion binding]; metal-binding site 698968003706 primosome assembly protein PriA; Provisional; Region: PRK14873 698968003707 S-adenosylmethionine synthetase; Validated; Region: PRK05250 698968003708 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 698968003709 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 698968003710 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 698968003711 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 698968003712 Flavoprotein; Region: Flavoprotein; pfam02441 698968003713 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 698968003714 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 698968003715 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 698968003716 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 698968003717 catalytic site [active] 698968003718 G-X2-G-X-G-K; other site 698968003719 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 698968003720 active site 698968003721 dimer interface [polypeptide binding]; other site 698968003722 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 698968003723 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698968003724 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698968003725 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 698968003726 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698968003727 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698968003728 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 698968003729 IMP binding site; other site 698968003730 dimer interface [polypeptide binding]; other site 698968003731 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 698968003732 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 698968003733 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 698968003734 catalytic site [active] 698968003735 subunit interface [polypeptide binding]; other site 698968003736 dihydroorotase; Validated; Region: pyrC; PRK09357 698968003737 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698968003738 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 698968003739 active site 698968003740 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 698968003741 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698968003742 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698968003743 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 698968003744 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698968003745 active site 698968003746 hydrophobic ligand binding site; other site 698968003747 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698968003748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968003749 TIGR01777 family protein; Region: yfcH 698968003750 NAD(P) binding site [chemical binding]; other site 698968003751 active site 698968003752 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 698968003753 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 698968003754 elongation factor P; Validated; Region: PRK00529 698968003755 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 698968003756 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 698968003757 RNA binding site [nucleotide binding]; other site 698968003758 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 698968003759 RNA binding site [nucleotide binding]; other site 698968003760 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698968003761 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698968003762 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698968003763 active site 698968003764 Dehydroquinase class II; Region: DHquinase_II; pfam01220 698968003765 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 698968003766 trimer interface [polypeptide binding]; other site 698968003767 active site 698968003768 dimer interface [polypeptide binding]; other site 698968003769 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 698968003770 active site 698968003771 dimer interface [polypeptide binding]; other site 698968003772 metal binding site [ion binding]; metal-binding site 698968003773 shikimate kinase; Reviewed; Region: aroK; PRK00131 698968003774 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 698968003775 ADP binding site [chemical binding]; other site 698968003776 magnesium binding site [ion binding]; other site 698968003777 putative shikimate binding site; other site 698968003778 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 698968003779 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 698968003780 Tetramer interface [polypeptide binding]; other site 698968003781 active site 698968003782 FMN-binding site [chemical binding]; other site 698968003783 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 698968003784 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698968003785 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698968003786 shikimate binding site; other site 698968003787 NAD(P) binding site [chemical binding]; other site 698968003788 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 698968003789 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 698968003790 dimerization interface [polypeptide binding]; other site 698968003791 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 698968003792 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 698968003793 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 698968003794 motif 1; other site 698968003795 active site 698968003796 motif 2; other site 698968003797 motif 3; other site 698968003798 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698968003799 DHHA1 domain; Region: DHHA1; pfam02272 698968003800 recombination factor protein RarA; Reviewed; Region: PRK13342 698968003801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968003802 Walker A motif; other site 698968003803 ATP binding site [chemical binding]; other site 698968003804 Walker B motif; other site 698968003805 arginine finger; other site 698968003806 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 698968003807 Phosphotransferase enzyme family; Region: APH; pfam01636 698968003808 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698968003809 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 698968003810 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 698968003811 dimer interface [polypeptide binding]; other site 698968003812 anticodon binding site; other site 698968003813 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 698968003814 homodimer interface [polypeptide binding]; other site 698968003815 motif 1; other site 698968003816 active site 698968003817 motif 2; other site 698968003818 GAD domain; Region: GAD; pfam02938 698968003819 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698968003820 active site 698968003821 motif 3; other site 698968003822 Predicted metalloprotease [General function prediction only]; Region: COG2321 698968003823 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 698968003824 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968003825 ATP binding site [chemical binding]; other site 698968003826 putative Mg++ binding site [ion binding]; other site 698968003827 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968003828 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 698968003829 nucleotide binding region [chemical binding]; other site 698968003830 ATP-binding site [chemical binding]; other site 698968003831 Predicted membrane protein [Function unknown]; Region: COG1511 698968003832 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698968003833 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698968003834 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698968003835 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698968003836 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698968003837 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968003838 Q-loop/lid; other site 698968003839 ABC transporter signature motif; other site 698968003840 Walker B; other site 698968003841 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698968003842 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698968003843 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698968003844 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698968003845 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698968003846 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 698968003847 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 698968003848 dimer interface [polypeptide binding]; other site 698968003849 motif 1; other site 698968003850 active site 698968003851 motif 2; other site 698968003852 motif 3; other site 698968003853 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 698968003854 anticodon binding site; other site 698968003855 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698968003856 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 698968003857 dimer interface [polypeptide binding]; other site 698968003858 catalytic triad [active] 698968003859 peroxidatic and resolving cysteines [active] 698968003860 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698968003861 active site 698968003862 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698968003863 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698968003864 Zn2+ binding site [ion binding]; other site 698968003865 Mg2+ binding site [ion binding]; other site 698968003866 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698968003867 synthetase active site [active] 698968003868 NTP binding site [chemical binding]; other site 698968003869 metal binding site [ion binding]; metal-binding site 698968003870 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 698968003871 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 698968003872 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698968003873 active site 698968003874 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 698968003875 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698968003876 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 698968003877 Protein export membrane protein; Region: SecD_SecF; cl14618 698968003878 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 698968003879 Protein export membrane protein; Region: SecD_SecF; cl14618 698968003880 Preprotein translocase subunit; Region: YajC; pfam02699 698968003881 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 698968003882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968003883 Walker A motif; other site 698968003884 ATP binding site [chemical binding]; other site 698968003885 Walker B motif; other site 698968003886 arginine finger; other site 698968003887 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 698968003888 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 698968003889 RuvA N terminal domain; Region: RuvA_N; pfam01330 698968003890 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 698968003891 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 698968003892 active site 698968003893 putative DNA-binding cleft [nucleotide binding]; other site 698968003894 dimer interface [polypeptide binding]; other site 698968003895 hypothetical protein; Validated; Region: PRK00110 698968003896 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 698968003897 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 698968003898 active site 698968003899 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 698968003900 catalytic triad [active] 698968003901 dimer interface [polypeptide binding]; other site 698968003902 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 698968003903 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 698968003904 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698968003905 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698968003906 catalytic residue [active] 698968003907 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698968003908 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698968003909 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 698968003910 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 698968003911 putative acyl-acceptor binding pocket; other site 698968003912 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698968003913 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 698968003914 nucleotide binding site/active site [active] 698968003915 HIT family signature motif; other site 698968003916 catalytic residue [active] 698968003917 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 698968003918 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698968003919 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 698968003920 active site 698968003921 dimer interface [polypeptide binding]; other site 698968003922 motif 1; other site 698968003923 motif 2; other site 698968003924 motif 3; other site 698968003925 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 698968003926 anticodon binding site; other site 698968003927 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 698968003928 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 698968003929 Protein of unknown function (DUF461); Region: DUF461; pfam04314 698968003930 CopC domain; Region: CopC; cl01012 698968003931 hypothetical protein; Provisional; Region: PRK14059 698968003932 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 698968003933 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 698968003934 SelR domain; Region: SelR; pfam01641 698968003935 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 698968003936 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 698968003937 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 698968003938 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 698968003939 catalytic site [active] 698968003940 putative active site [active] 698968003941 putative substrate binding site [chemical binding]; other site 698968003942 HRDC domain; Region: HRDC; pfam00570 698968003943 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 698968003944 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 698968003945 TPP-binding site; other site 698968003946 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698968003947 PYR/PP interface [polypeptide binding]; other site 698968003948 dimer interface [polypeptide binding]; other site 698968003949 TPP binding site [chemical binding]; other site 698968003950 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698968003951 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 698968003952 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 698968003953 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 698968003954 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698968003955 trimer interface [polypeptide binding]; other site 698968003956 active site 698968003957 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 698968003958 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 698968003959 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698968003960 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 698968003961 active site 698968003962 dimerization interface [polypeptide binding]; other site 698968003963 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698968003964 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698968003965 nucleotide binding site [chemical binding]; other site 698968003966 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698968003967 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698968003968 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698968003969 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698968003970 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698968003971 DNA binding residues [nucleotide binding] 698968003972 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698968003973 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968003974 ATP binding site [chemical binding]; other site 698968003975 putative Mg++ binding site [ion binding]; other site 698968003976 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 698968003977 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 698968003978 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 698968003979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968003980 S-adenosylmethionine binding site [chemical binding]; other site 698968003981 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 698968003982 putative active site [active] 698968003983 dimerization interface [polypeptide binding]; other site 698968003984 putative tRNAtyr binding site [nucleotide binding]; other site 698968003985 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698968003986 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698968003987 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698968003988 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698968003989 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698968003990 DNA binding residues [nucleotide binding] 698968003991 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698968003992 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698968003993 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698968003994 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 698968003995 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 698968003996 NAD binding site [chemical binding]; other site 698968003997 homodimer interface [polypeptide binding]; other site 698968003998 active site 698968003999 substrate binding site [chemical binding]; other site 698968004000 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 698968004001 PAC2 family; Region: PAC2; pfam09754 698968004002 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968004003 ATP binding site [chemical binding]; other site 698968004004 putative Mg++ binding site [ion binding]; other site 698968004005 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968004006 nucleotide binding region [chemical binding]; other site 698968004007 ATP-binding site [chemical binding]; other site 698968004008 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 698968004009 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 698968004010 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 698968004011 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698968004012 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 698968004013 dimer interface [polypeptide binding]; other site 698968004014 decamer (pentamer of dimers) interface [polypeptide binding]; other site 698968004015 catalytic triad [active] 698968004016 peroxidatic and resolving cysteines [active] 698968004017 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698968004018 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 698968004019 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 698968004020 dimerization interface [polypeptide binding]; other site 698968004021 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 698968004022 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968004023 ATP binding site [chemical binding]; other site 698968004024 putative Mg++ binding site [ion binding]; other site 698968004025 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968004026 nucleotide binding region [chemical binding]; other site 698968004027 ATP-binding site [chemical binding]; other site 698968004028 Helicase associated domain (HA2); Region: HA2; pfam04408 698968004029 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 698968004030 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 698968004031 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 698968004032 ATP cone domain; Region: ATP-cone; pfam03477 698968004033 LexA repressor; Validated; Region: PRK00215 698968004034 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 698968004035 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698968004036 Catalytic site [active] 698968004037 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698968004038 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 698968004039 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698968004040 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 698968004041 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 698968004042 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 698968004043 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 698968004044 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698968004045 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698968004046 DNA-binding site [nucleotide binding]; DNA binding site 698968004047 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698968004048 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 698968004049 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 698968004050 putative substrate binding site [chemical binding]; other site 698968004051 putative ATP binding site [chemical binding]; other site 698968004052 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698968004053 dimerization domain swap beta strand [polypeptide binding]; other site 698968004054 regulatory protein interface [polypeptide binding]; other site 698968004055 active site 698968004056 regulatory phosphorylation site [posttranslational modification]; other site 698968004057 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 698968004058 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698968004059 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 698968004060 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698968004061 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 698968004062 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 698968004063 GTPases [General function prediction only]; Region: HflX; COG2262 698968004064 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 698968004065 HflX GTPase family; Region: HflX; cd01878 698968004066 G1 box; other site 698968004067 GTP/Mg2+ binding site [chemical binding]; other site 698968004068 Switch I region; other site 698968004069 G2 box; other site 698968004070 G3 box; other site 698968004071 Switch II region; other site 698968004072 G4 box; other site 698968004073 G5 box; other site 698968004074 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 698968004075 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698968004076 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698968004077 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 698968004078 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 698968004079 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698968004080 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698968004081 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698968004082 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698968004083 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 698968004084 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 698968004085 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698968004086 FeS/SAM binding site; other site 698968004087 recombination regulator RecX; Reviewed; Region: recX; PRK00117 698968004088 recombinase A; Provisional; Region: recA; PRK09354 698968004089 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 698968004090 hexamer interface [polypeptide binding]; other site 698968004091 Walker A motif; other site 698968004092 ATP binding site [chemical binding]; other site 698968004093 Walker B motif; other site 698968004094 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 698968004095 BioY family; Region: BioY; pfam02632 698968004096 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698968004097 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698968004098 Walker A/P-loop; other site 698968004099 ATP binding site [chemical binding]; other site 698968004100 Q-loop/lid; other site 698968004101 ABC transporter signature motif; other site 698968004102 Walker B; other site 698968004103 D-loop; other site 698968004104 H-loop/switch region; other site 698968004105 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698968004106 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698968004107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698968004108 sequence-specific DNA binding site [nucleotide binding]; other site 698968004109 salt bridge; other site 698968004110 Competence-damaged protein; Region: CinA; pfam02464 698968004111 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698968004112 YCII-related domain; Region: YCII; cl00999 698968004113 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 698968004114 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 698968004115 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698968004116 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 698968004117 TIGR03085 family protein; Region: TIGR03085 698968004118 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 698968004119 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698968004120 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 698968004121 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 698968004122 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698968004123 dimer interface [polypeptide binding]; other site 698968004124 active site 698968004125 catalytic residue [active] 698968004126 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 698968004127 dihydrodipicolinate reductase; Provisional; Region: PRK00048 698968004128 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 698968004129 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 698968004130 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 698968004131 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 698968004132 oligomer interface [polypeptide binding]; other site 698968004133 RNA binding site [nucleotide binding]; other site 698968004134 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 698968004135 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 698968004136 RNase E interface [polypeptide binding]; other site 698968004137 trimer interface [polypeptide binding]; other site 698968004138 active site 698968004139 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 698968004140 putative nucleic acid binding region [nucleotide binding]; other site 698968004141 G-X-X-G motif; other site 698968004142 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 698968004143 RNA binding site [nucleotide binding]; other site 698968004144 domain interface; other site 698968004145 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 698968004146 16S/18S rRNA binding site [nucleotide binding]; other site 698968004147 S13e-L30e interaction site [polypeptide binding]; other site 698968004148 25S rRNA binding site [nucleotide binding]; other site 698968004149 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 698968004150 active site 698968004151 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 698968004152 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 698968004153 active site 698968004154 Riboflavin kinase; Region: Flavokinase; smart00904 698968004155 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 698968004156 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 698968004157 RNA binding site [nucleotide binding]; other site 698968004158 active site 698968004159 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 698968004160 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 698968004161 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 698968004162 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698968004163 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698968004164 active site 698968004165 metal binding site [ion binding]; metal-binding site 698968004166 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698968004167 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 698968004168 DHH family; Region: DHH; pfam01368 698968004169 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 698968004170 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698968004171 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698968004172 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 698968004173 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 698968004174 G1 box; other site 698968004175 putative GEF interaction site [polypeptide binding]; other site 698968004176 GTP/Mg2+ binding site [chemical binding]; other site 698968004177 Switch I region; other site 698968004178 G2 box; other site 698968004179 G3 box; other site 698968004180 Switch II region; other site 698968004181 G4 box; other site 698968004182 G5 box; other site 698968004183 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 698968004184 Translation-initiation factor 2; Region: IF-2; pfam11987 698968004185 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 698968004186 Protein of unknown function (DUF448); Region: DUF448; pfam04296 698968004187 putative RNA binding cleft [nucleotide binding]; other site 698968004188 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 698968004189 NusA N-terminal domain; Region: NusA_N; pfam08529 698968004190 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 698968004191 RNA binding site [nucleotide binding]; other site 698968004192 homodimer interface [polypeptide binding]; other site 698968004193 NusA-like KH domain; Region: KH_5; pfam13184 698968004194 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 698968004195 G-X-X-G motif; other site 698968004196 ribosome maturation protein RimP; Reviewed; Region: PRK00092 698968004197 Sm and related proteins; Region: Sm_like; cl00259 698968004198 prolyl-tRNA synthetase; Provisional; Region: PRK09194 698968004199 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 698968004200 dimer interface [polypeptide binding]; other site 698968004201 motif 1; other site 698968004202 active site 698968004203 motif 2; other site 698968004204 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 698968004205 putative deacylase active site [active] 698968004206 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698968004207 active site 698968004208 motif 3; other site 698968004209 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 698968004210 anticodon binding site; other site 698968004211 hypothetical protein; Validated; Region: PRK02101 698968004212 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 698968004213 active site 698968004214 SAM binding site [chemical binding]; other site 698968004215 homodimer interface [polypeptide binding]; other site 698968004216 Uncharacterized conserved protein [Function unknown]; Region: COG0397 698968004217 hypothetical protein; Validated; Region: PRK00029 698968004218 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698968004219 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 698968004220 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 698968004221 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 698968004222 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698968004223 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 698968004224 catalytic triad [active] 698968004225 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 698968004226 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 698968004227 Walker A motif; other site 698968004228 homodimer interface [polypeptide binding]; other site 698968004229 ATP binding site [chemical binding]; other site 698968004230 hydroxycobalamin binding site [chemical binding]; other site 698968004231 Walker B motif; other site 698968004232 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 698968004233 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 698968004234 metal ion-dependent adhesion site (MIDAS); other site 698968004235 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 698968004236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968004237 Walker A motif; other site 698968004238 ATP binding site [chemical binding]; other site 698968004239 Walker B motif; other site 698968004240 arginine finger; other site 698968004241 malate:quinone oxidoreductase; Validated; Region: PRK05257 698968004242 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 698968004243 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698968004244 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698968004245 mycothione reductase; Region: mycothione_red; TIGR03452 698968004246 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698968004247 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698968004248 cobyric acid synthase; Provisional; Region: PRK00784 698968004249 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 698968004250 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698968004251 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698968004252 catalytic triad [active] 698968004253 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698968004254 active site 698968004255 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 698968004256 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698968004257 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 698968004258 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698968004259 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698968004260 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 698968004261 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698968004262 active site 698968004263 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 698968004264 protein binding site [polypeptide binding]; other site 698968004265 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 698968004266 putative substrate binding region [chemical binding]; other site 698968004267 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 698968004268 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 698968004269 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 698968004270 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 698968004271 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 698968004272 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 698968004273 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698968004274 FeS/SAM binding site; other site 698968004275 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 698968004276 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 698968004277 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 698968004278 ribosome recycling factor; Reviewed; Region: frr; PRK00083 698968004279 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 698968004280 hinge region; other site 698968004281 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 698968004282 putative nucleotide binding site [chemical binding]; other site 698968004283 uridine monophosphate binding site [chemical binding]; other site 698968004284 homohexameric interface [polypeptide binding]; other site 698968004285 elongation factor Ts; Provisional; Region: tsf; PRK09377 698968004286 UBA/TS-N domain; Region: UBA; pfam00627 698968004287 Elongation factor TS; Region: EF_TS; pfam00889 698968004288 Elongation factor TS; Region: EF_TS; pfam00889 698968004289 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 698968004290 rRNA interaction site [nucleotide binding]; other site 698968004291 S8 interaction site; other site 698968004292 putative laminin-1 binding site; other site 698968004293 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698968004294 Peptidase family M23; Region: Peptidase_M23; pfam01551 698968004295 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698968004296 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 698968004297 active site 698968004298 DNA binding site [nucleotide binding] 698968004299 Int/Topo IB signature motif; other site 698968004300 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 698968004301 DNA protecting protein DprA; Region: dprA; TIGR00732 698968004302 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 698968004303 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 698968004304 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698968004305 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968004306 Walker A motif; other site 698968004307 ATP binding site [chemical binding]; other site 698968004308 Walker B motif; other site 698968004309 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 698968004310 hypothetical protein; Reviewed; Region: PRK12497 698968004311 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 698968004312 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 698968004313 RNA/DNA hybrid binding site [nucleotide binding]; other site 698968004314 active site 698968004315 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 698968004316 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698968004317 Catalytic site [active] 698968004318 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698968004319 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 698968004320 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 698968004321 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 698968004322 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 698968004323 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698968004324 RNA binding site [nucleotide binding]; other site 698968004325 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 698968004326 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 698968004327 RimM N-terminal domain; Region: RimM; pfam01782 698968004328 PRC-barrel domain; Region: PRC; pfam05239 698968004329 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 698968004330 signal recognition particle protein; Provisional; Region: PRK10867 698968004331 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 698968004332 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 698968004333 P loop; other site 698968004334 GTP binding site [chemical binding]; other site 698968004335 Signal peptide binding domain; Region: SRP_SPB; pfam02978 698968004336 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 698968004337 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698968004338 metal binding triad; other site 698968004339 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698968004340 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698968004341 Zn2+ binding site [ion binding]; other site 698968004342 Mg2+ binding site [ion binding]; other site 698968004343 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 698968004344 Nitrogen regulatory protein P-II; Region: P-II; smart00938 698968004345 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 698968004346 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 698968004347 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 698968004348 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698968004349 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 698968004350 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698968004351 Walker A/P-loop; other site 698968004352 ATP binding site [chemical binding]; other site 698968004353 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 698968004354 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698968004355 ABC transporter signature motif; other site 698968004356 Walker B; other site 698968004357 D-loop; other site 698968004358 H-loop/switch region; other site 698968004359 Acylphosphatase; Region: Acylphosphatase; cl00551 698968004360 potential frameshift: common BLAST hit: gi|38234117|ref|NP_939884.1| amino acid carrier protein 698968004361 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698968004362 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 698968004363 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698968004364 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 698968004365 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 698968004366 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 698968004367 DNA binding site [nucleotide binding] 698968004368 catalytic residue [active] 698968004369 H2TH interface [polypeptide binding]; other site 698968004370 putative catalytic residues [active] 698968004371 turnover-facilitating residue; other site 698968004372 intercalation triad [nucleotide binding]; other site 698968004373 8OG recognition residue [nucleotide binding]; other site 698968004374 putative reading head residues; other site 698968004375 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698968004376 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698968004377 ribonuclease III; Reviewed; Region: rnc; PRK00102 698968004378 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 698968004379 dimerization interface [polypeptide binding]; other site 698968004380 active site 698968004381 metal binding site [ion binding]; metal-binding site 698968004382 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 698968004383 dsRNA binding site [nucleotide binding]; other site 698968004384 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 698968004385 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698968004386 glutamate dehydrogenase; Provisional; Region: PRK09414 698968004387 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 698968004388 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 698968004389 NAD(P) binding site [chemical binding]; other site 698968004390 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 698968004391 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698968004392 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698968004393 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 698968004394 metal binding site [ion binding]; metal-binding site 698968004395 putative dimer interface [polypeptide binding]; other site 698968004396 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 698968004397 homodimer interface [polypeptide binding]; other site 698968004398 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 698968004399 active site pocket [active] 698968004400 pyruvate kinase; Provisional; Region: PRK06247 698968004401 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 698968004402 domain interfaces; other site 698968004403 active site 698968004404 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 698968004405 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698968004406 active site 698968004407 ribulose/triose binding site [chemical binding]; other site 698968004408 phosphate binding site [ion binding]; other site 698968004409 substrate (anthranilate) binding pocket [chemical binding]; other site 698968004410 product (indole) binding pocket [chemical binding]; other site 698968004411 trp region conserved hypothetical membrane protein; Region: trp_oprn_chp; TIGR02234 698968004412 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 698968004413 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 698968004414 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698968004415 substrate binding site [chemical binding]; other site 698968004416 glutamase interaction surface [polypeptide binding]; other site 698968004417 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698968004418 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698968004419 active site 698968004420 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 698968004421 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698968004422 catalytic residues [active] 698968004423 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 698968004424 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 698968004425 putative active site [active] 698968004426 oxyanion strand; other site 698968004427 catalytic triad [active] 698968004428 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698968004429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968004430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968004431 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 698968004432 putative active site pocket [active] 698968004433 4-fold oligomerization interface [polypeptide binding]; other site 698968004434 metal binding residues [ion binding]; metal-binding site 698968004435 3-fold/trimer interface [polypeptide binding]; other site 698968004436 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 698968004437 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698968004438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968004439 homodimer interface [polypeptide binding]; other site 698968004440 catalytic residue [active] 698968004441 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 698968004442 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 698968004443 NAD binding site [chemical binding]; other site 698968004444 dimerization interface [polypeptide binding]; other site 698968004445 product binding site; other site 698968004446 substrate binding site [chemical binding]; other site 698968004447 zinc binding site [ion binding]; other site 698968004448 catalytic residues [active] 698968004449 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 698968004450 tetracycline repressor protein TetR; Provisional; Region: PRK13756 698968004451 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698968004452 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 698968004453 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 698968004454 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 698968004455 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 698968004456 active site 698968004457 catalytic site [active] 698968004458 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 698968004459 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 698968004460 active site 698968004461 catalytic site [active] 698968004462 substrate binding site [chemical binding]; other site 698968004463 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698968004464 synthetase active site [active] 698968004465 NTP binding site [chemical binding]; other site 698968004466 metal binding site [ion binding]; metal-binding site 698968004467 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698968004468 RNA binding surface [nucleotide binding]; other site 698968004469 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 698968004470 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 698968004471 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 698968004472 threonine dehydratase; Validated; Region: PRK08639 698968004473 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698968004474 tetramer interface [polypeptide binding]; other site 698968004475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968004476 catalytic residue [active] 698968004477 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 698968004478 putative Ile/Val binding site [chemical binding]; other site 698968004479 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 698968004480 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 698968004481 active site 698968004482 PHP Thumb interface [polypeptide binding]; other site 698968004483 metal binding site [ion binding]; metal-binding site 698968004484 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698968004485 generic binding surface II; other site 698968004486 generic binding surface I; other site 698968004487 Predicted permeases [General function prediction only]; Region: RarD; COG2962 698968004488 EamA-like transporter family; Region: EamA; cl17759 698968004489 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 698968004490 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698968004491 RNA binding surface [nucleotide binding]; other site 698968004492 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698968004493 active site 698968004494 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 698968004495 lipoprotein signal peptidase; Provisional; Region: PRK14787 698968004496 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698968004497 active site 698968004498 homotetramer interface [polypeptide binding]; other site 698968004499 homodimer interface [polypeptide binding]; other site 698968004500 DNA polymerase IV; Provisional; Region: PRK03348 698968004501 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 698968004502 active site 698968004503 DNA binding site [nucleotide binding] 698968004504 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 698968004505 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698968004506 HIGH motif; other site 698968004507 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698968004508 active site 698968004509 KMSKS motif; other site 698968004510 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 698968004511 tRNA binding surface [nucleotide binding]; other site 698968004512 anticodon binding site; other site 698968004513 DivIVA domain; Region: DivI1A_domain; TIGR03544 698968004514 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698968004515 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 698968004516 YGGT family; Region: YGGT; cl00508 698968004517 Protein of unknown function (DUF552); Region: DUF552; cl00775 698968004518 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 698968004519 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 698968004520 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 698968004521 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 698968004522 nucleotide binding site [chemical binding]; other site 698968004523 SulA interaction site; other site 698968004524 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 698968004525 Cell division protein FtsQ; Region: FtsQ; pfam03799 698968004526 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 698968004527 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698968004528 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698968004529 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698968004530 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 698968004531 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 698968004532 active site 698968004533 homodimer interface [polypeptide binding]; other site 698968004534 cell division protein FtsW; Region: ftsW; TIGR02614 698968004535 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 698968004536 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698968004537 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698968004538 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 698968004539 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 698968004540 Mg++ binding site [ion binding]; other site 698968004541 putative catalytic motif [active] 698968004542 putative substrate binding site [chemical binding]; other site 698968004543 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 698968004544 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698968004545 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698968004546 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698968004547 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 698968004548 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698968004549 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698968004550 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698968004551 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698968004552 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698968004553 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698968004554 MraW methylase family; Region: Methyltransf_5; cl17771 698968004555 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 698968004556 cell division protein MraZ; Reviewed; Region: PRK00326 698968004557 MraZ protein; Region: MraZ; pfam02381 698968004558 MraZ protein; Region: MraZ; pfam02381 698968004559 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 698968004560 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698968004561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698968004562 Coenzyme A binding pocket [chemical binding]; other site 698968004563 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 698968004564 FAD binding site [chemical binding]; other site 698968004565 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698968004566 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698968004567 substrate binding pocket [chemical binding]; other site 698968004568 chain length determination region; other site 698968004569 substrate-Mg2+ binding site; other site 698968004570 catalytic residues [active] 698968004571 aspartate-rich region 1; other site 698968004572 active site lid residues [active] 698968004573 aspartate-rich region 2; other site 698968004574 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698968004575 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698968004576 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698968004577 active site 698968004578 ATP binding site [chemical binding]; other site 698968004579 substrate binding site [chemical binding]; other site 698968004580 activation loop (A-loop); other site 698968004581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698968004582 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698968004583 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698968004584 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698968004585 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698968004586 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 698968004587 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698968004588 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698968004589 putative acyl-acceptor binding pocket; other site 698968004590 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698968004591 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698968004592 nucleotide binding site [chemical binding]; other site 698968004593 Tesmin/TSO1-like CXC domain; Region: CXC; pfam03638 698968004594 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698968004595 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698968004596 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698968004597 NlpC/P60 family; Region: NLPC_P60; pfam00877 698968004598 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698968004599 NlpC/P60 family; Region: NLPC_P60; pfam00877 698968004600 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 698968004601 heme bH binding site [chemical binding]; other site 698968004602 intrachain domain interface; other site 698968004603 heme bL binding site [chemical binding]; other site 698968004604 interchain domain interface [polypeptide binding]; other site 698968004605 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 698968004606 Qo binding site; other site 698968004607 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 698968004608 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698968004609 iron-sulfur cluster [ion binding]; other site 698968004610 [2Fe-2S] cluster binding site [ion binding]; other site 698968004611 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698968004612 Cytochrome c; Region: Cytochrom_C; pfam00034 698968004613 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698968004614 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 698968004615 Subunit I/III interface [polypeptide binding]; other site 698968004616 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 698968004617 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 698968004618 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 698968004619 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 698968004620 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 698968004621 active site 698968004622 dimer interface [polypeptide binding]; other site 698968004623 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 698968004624 Ligand Binding Site [chemical binding]; other site 698968004625 Molecular Tunnel; other site 698968004626 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 698968004627 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 698968004628 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 698968004629 homotrimer interface [polypeptide binding]; other site 698968004630 Walker A motif; other site 698968004631 GTP binding site [chemical binding]; other site 698968004632 Walker B motif; other site 698968004633 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 698968004634 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 698968004635 putative dimer interface [polypeptide binding]; other site 698968004636 active site pocket [active] 698968004637 putative cataytic base [active] 698968004638 cobalamin synthase; Reviewed; Region: cobS; PRK00235 698968004639 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 698968004640 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 698968004641 homodimer interface [polypeptide binding]; other site 698968004642 substrate-cofactor binding pocket; other site 698968004643 catalytic residue [active] 698968004644 multifunctional aminopeptidase A; Provisional; Region: PRK00913 698968004645 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 698968004646 interface (dimer of trimers) [polypeptide binding]; other site 698968004647 Substrate-binding/catalytic site; other site 698968004648 Zn-binding sites [ion binding]; other site 698968004649 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 698968004650 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698968004651 E3 interaction surface; other site 698968004652 lipoyl attachment site [posttranslational modification]; other site 698968004653 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698968004654 E3 interaction surface; other site 698968004655 lipoyl attachment site [posttranslational modification]; other site 698968004656 e3 binding domain; Region: E3_binding; pfam02817 698968004657 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698968004658 lipoate-protein ligase B; Provisional; Region: PRK14345 698968004659 lipoyl synthase; Provisional; Region: PRK05481 698968004660 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698968004661 FeS/SAM binding site; other site 698968004662 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 698968004663 RDD family; Region: RDD; pfam06271 698968004664 glutamine synthetase, type I; Region: GlnA; TIGR00653 698968004665 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698968004666 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698968004667 Predicted peptidase [General function prediction only]; Region: COG4099 698968004668 CsbD-like; Region: CsbD; pfam05532 698968004669 Predicted permease [General function prediction only]; Region: COG2056 698968004670 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 698968004671 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698968004672 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698968004673 DNA-binding site [nucleotide binding]; DNA binding site 698968004674 FCD domain; Region: FCD; pfam07729 698968004675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968004676 putative substrate translocation pore; other site 698968004677 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 698968004678 nudix motif; other site 698968004679 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 698968004680 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 698968004681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968004682 catalytic residue [active] 698968004683 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 698968004684 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 698968004685 heme binding pocket [chemical binding]; other site 698968004686 heme ligand [chemical binding]; other site 698968004687 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 698968004688 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698968004689 metal binding triad; other site 698968004690 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698968004691 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698968004692 metal binding triad; other site 698968004693 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698968004694 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 698968004695 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698968004696 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698968004697 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 698968004698 putative active site; other site 698968004699 putative metal binding residues [ion binding]; other site 698968004700 signature motif; other site 698968004701 putative triphosphate binding site [ion binding]; other site 698968004702 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 698968004703 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 698968004704 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698968004705 potential frameshift: common BLAST hit: gi|300858911|ref|YP_003783894.1| ribonuclease R 698968004706 RNB domain; Region: RNB; pfam00773 698968004707 Predicted membrane protein [General function prediction only]; Region: COG4194 698968004708 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 698968004709 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 698968004710 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 698968004711 RNA/DNA hybrid binding site [nucleotide binding]; other site 698968004712 active site 698968004713 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698968004714 catalytic core [active] 698968004715 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 698968004716 Putative zinc ribbon domain; Region: DUF164; pfam02591 698968004717 Uncharacterized conserved protein [Function unknown]; Region: COG0327 698968004718 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698968004719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 698968004720 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698968004721 hypothetical protein; Provisional; Region: PRK07908 698968004722 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698968004723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968004724 homodimer interface [polypeptide binding]; other site 698968004725 catalytic residue [active] 698968004726 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 698968004727 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968004728 motif II; other site 698968004729 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 698968004730 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 698968004731 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 698968004732 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 698968004733 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 698968004734 dimer interface [polypeptide binding]; other site 698968004735 TPP-binding site [chemical binding]; other site 698968004736 Electron transfer DM13; Region: DM13; pfam10517 698968004737 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698968004738 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698968004739 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698968004740 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 698968004741 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698968004742 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698968004743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968004744 active site 698968004745 motif I; other site 698968004746 motif II; other site 698968004747 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968004748 motif II; other site 698968004749 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698968004750 Beta-lactamase; Region: Beta-lactamase; pfam00144 698968004751 Predicted membrane protein [Function unknown]; Region: COG2860 698968004752 UPF0126 domain; Region: UPF0126; pfam03458 698968004753 UPF0126 domain; Region: UPF0126; pfam03458 698968004754 DNA primase; Validated; Region: dnaG; PRK05667 698968004755 CHC2 zinc finger; Region: zf-CHC2; pfam01807 698968004756 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 698968004757 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 698968004758 active site 698968004759 metal binding site [ion binding]; metal-binding site 698968004760 interdomain interaction site; other site 698968004761 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 698968004762 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 698968004763 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 698968004764 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 698968004765 glutaminase active site [active] 698968004766 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698968004767 dimer interface [polypeptide binding]; other site 698968004768 active site 698968004769 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 698968004770 dimer interface [polypeptide binding]; other site 698968004771 active site 698968004772 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 698968004773 active site 698968004774 barstar interaction site; other site 698968004775 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 698968004776 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698968004777 Zn2+ binding site [ion binding]; other site 698968004778 Mg2+ binding site [ion binding]; other site 698968004779 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 698968004780 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698968004781 putative active site [active] 698968004782 Repair protein; Region: Repair_PSII; pfam04536 698968004783 glycyl-tRNA synthetase; Provisional; Region: PRK04173 698968004784 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698968004785 motif 1; other site 698968004786 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 698968004787 active site 698968004788 motif 2; other site 698968004789 motif 3; other site 698968004790 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 698968004791 anticodon binding site; other site 698968004792 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698968004793 putative DNA binding site [nucleotide binding]; other site 698968004794 dimerization interface [polypeptide binding]; other site 698968004795 putative Zn2+ binding site [ion binding]; other site 698968004796 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698968004797 metal binding site 2 [ion binding]; metal-binding site 698968004798 putative DNA binding helix; other site 698968004799 metal binding site 1 [ion binding]; metal-binding site 698968004800 dimer interface [polypeptide binding]; other site 698968004801 structural Zn2+ binding site [ion binding]; other site 698968004802 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 698968004803 diiron binding motif [ion binding]; other site 698968004804 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 698968004805 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698968004806 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 698968004807 catalytic residue [active] 698968004808 putative FPP diphosphate binding site; other site 698968004809 putative FPP binding hydrophobic cleft; other site 698968004810 dimer interface [polypeptide binding]; other site 698968004811 putative IPP diphosphate binding site; other site 698968004812 Recombination protein O N terminal; Region: RecO_N; pfam11967 698968004813 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 698968004814 Recombination protein O C terminal; Region: RecO_C; pfam02565 698968004815 GTPase Era; Reviewed; Region: era; PRK00089 698968004816 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 698968004817 G1 box; other site 698968004818 GTP/Mg2+ binding site [chemical binding]; other site 698968004819 Switch I region; other site 698968004820 G2 box; other site 698968004821 Switch II region; other site 698968004822 G3 box; other site 698968004823 G4 box; other site 698968004824 G5 box; other site 698968004825 KH domain; Region: KH_2; pfam07650 698968004826 pyridoxamine kinase; Validated; Region: PRK05756 698968004827 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 698968004828 dimer interface [polypeptide binding]; other site 698968004829 pyridoxal binding site [chemical binding]; other site 698968004830 ATP binding site [chemical binding]; other site 698968004831 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698968004832 Domain of unknown function DUF21; Region: DUF21; pfam01595 698968004833 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698968004834 Transporter associated domain; Region: CorC_HlyC; smart01091 698968004835 metal-binding heat shock protein; Provisional; Region: PRK00016 698968004836 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 698968004837 PhoH-like protein; Region: PhoH; pfam02562 698968004838 RNA methyltransferase, RsmE family; Region: TIGR00046 698968004839 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 698968004840 chaperone protein DnaJ; Provisional; Region: PRK14278 698968004841 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698968004842 HSP70 interaction site [polypeptide binding]; other site 698968004843 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698968004844 Zn binding sites [ion binding]; other site 698968004845 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698968004846 dimer interface [polypeptide binding]; other site 698968004847 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 698968004848 coproporphyrinogen III oxidase; Validated; Region: PRK05628 698968004849 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698968004850 FeS/SAM binding site; other site 698968004851 HemN C-terminal domain; Region: HemN_C; pfam06969 698968004852 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698968004853 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698968004854 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698968004855 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698968004856 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 698968004857 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 698968004858 acyl-activating enzyme (AAE) consensus motif; other site 698968004859 putative AMP binding site [chemical binding]; other site 698968004860 putative active site [active] 698968004861 putative CoA binding site [chemical binding]; other site 698968004862 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 698968004863 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 698968004864 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 698968004865 active site 698968004866 Zn binding site [ion binding]; other site 698968004867 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698968004868 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698968004869 substrate binding pocket [chemical binding]; other site 698968004870 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 698968004871 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 698968004872 active site 698968004873 metal binding site [ion binding]; metal-binding site 698968004874 nudix motif; other site 698968004875 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698968004876 active site 698968004877 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698968004878 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698968004879 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968004880 Walker A/P-loop; other site 698968004881 ATP binding site [chemical binding]; other site 698968004882 Q-loop/lid; other site 698968004883 ABC transporter signature motif; other site 698968004884 Walker B; other site 698968004885 D-loop; other site 698968004886 H-loop/switch region; other site 698968004887 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 698968004888 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698968004889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968004890 homodimer interface [polypeptide binding]; other site 698968004891 catalytic residue [active] 698968004892 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 698968004893 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698968004894 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 698968004895 BCCT family transporter; Region: BCCT; pfam02028 698968004896 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698968004897 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 698968004898 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698968004899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968004900 dimer interface [polypeptide binding]; other site 698968004901 conserved gate region; other site 698968004902 putative PBP binding loops; other site 698968004903 ABC-ATPase subunit interface; other site 698968004904 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698968004905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968004906 dimer interface [polypeptide binding]; other site 698968004907 conserved gate region; other site 698968004908 putative PBP binding loops; other site 698968004909 ABC-ATPase subunit interface; other site 698968004910 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698968004911 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698968004912 Walker A/P-loop; other site 698968004913 ATP binding site [chemical binding]; other site 698968004914 Q-loop/lid; other site 698968004915 ABC transporter signature motif; other site 698968004916 Walker B; other site 698968004917 D-loop; other site 698968004918 H-loop/switch region; other site 698968004919 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698968004920 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698968004921 Walker A/P-loop; other site 698968004922 ATP binding site [chemical binding]; other site 698968004923 Q-loop/lid; other site 698968004924 ABC transporter signature motif; other site 698968004925 Walker B; other site 698968004926 D-loop; other site 698968004927 H-loop/switch region; other site 698968004928 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698968004929 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 698968004930 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698968004931 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698968004932 nucleotide binding site [chemical binding]; other site 698968004933 potential frameshift: common BLAST hit: gi|38234319|ref|NP_940086.1| oxidase 698968004934 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 698968004935 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698968004936 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698968004937 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 698968004938 active site residue [active] 698968004939 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 698968004940 putative homodimer interface [polypeptide binding]; other site 698968004941 putative homotetramer interface [polypeptide binding]; other site 698968004942 putative allosteric switch controlling residues; other site 698968004943 putative metal binding site [ion binding]; other site 698968004944 putative homodimer-homodimer interface [polypeptide binding]; other site 698968004945 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698968004946 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 698968004947 TrkA-N domain; Region: TrkA_N; pfam02254 698968004948 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 698968004949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968004950 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 698968004951 active site 698968004952 tetramer interface [polypeptide binding]; other site 698968004953 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698968004954 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 698968004955 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698968004956 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 698968004957 catalytic residues [active] 698968004958 catalytic nucleophile [active] 698968004959 Recombinase; Region: Recombinase; pfam07508 698968004960 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 698968004961 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698968004962 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 698968004963 catalytic residues [active] 698968004964 catalytic nucleophile [active] 698968004965 Recombinase; Region: Recombinase; pfam07508 698968004966 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698968004967 amidase catalytic site [active] 698968004968 Zn binding residues [ion binding]; other site 698968004969 substrate binding site [chemical binding]; other site 698968004970 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020 698968004971 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020 698968004972 Holin family; Region: Phage_holin_4; pfam05105 698968004973 Protein of unknown function (DUF1617); Region: DUF1617; pfam07761 698968004974 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 698968004975 Phage-related protein [Function unknown]; Region: COG4722 698968004976 Phage tail protein; Region: Sipho_tail; cl17486 698968004977 Phage-related protein [Function unknown]; Region: COG5412 698968004978 tape measure domain; Region: tape_meas_nterm; TIGR02675 698968004979 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 698968004980 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 698968004981 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 698968004982 oligomerization interface [polypeptide binding]; other site 698968004983 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 698968004984 Phage capsid family; Region: Phage_capsid; pfam05065 698968004985 Clp protease; Region: CLP_protease; pfam00574 698968004986 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 698968004987 oligomer interface [polypeptide binding]; other site 698968004988 active site residues [active] 698968004989 Phage-related protein [Function unknown]; Region: COG4695 698968004990 Phage portal protein; Region: Phage_portal; pfam04860 698968004991 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 698968004992 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 698968004993 ParB-like nuclease domain; Region: ParBc; pfam02195 698968004994 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 698968004995 DNA methylase; Region: N6_N4_Mtase; pfam01555 698968004996 S-adenosylmethionine synthetase; Provisional; Region: PRK12459 698968004997 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 698968004998 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 698968004999 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 698968005000 Phage terminase, small subunit; Region: Terminase_4; cl01525 698968005001 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 698968005002 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698968005003 active site 698968005004 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 698968005005 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968005006 ATP binding site [chemical binding]; other site 698968005007 putative Mg++ binding site [ion binding]; other site 698968005008 VRR-NUC domain; Region: VRR_NUC; cl17748 698968005009 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 698968005010 D5 N terminal like; Region: D5_N; pfam08706 698968005011 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 698968005012 Prophage antirepressor [Transcription]; Region: COG3617 698968005013 BRO family, N-terminal domain; Region: Bro-N; smart01040 698968005014 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 698968005015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 698968005016 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 698968005017 Integrase core domain; Region: rve; pfam00665 698968005018 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 698968005019 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 698968005020 active site 698968005021 DNA binding site [nucleotide binding] 698968005022 catalytic site [active] 698968005023 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 698968005024 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 698968005025 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698968005026 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 698968005027 DNA binding residues [nucleotide binding] 698968005028 Predicted ATPase [General function prediction only]; Region: COG5293 698968005029 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 698968005030 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 698968005031 non-specific DNA binding site [nucleotide binding]; other site 698968005032 salt bridge; other site 698968005033 sequence-specific DNA binding site [nucleotide binding]; other site 698968005034 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 698968005035 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 698968005036 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 698968005037 DNA methylase; Region: N6_N4_Mtase; pfam01555 698968005038 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698968005039 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 698968005040 Mrr N-terminal domain; Region: Mrr_N; pfam14338 698968005041 Restriction endonuclease; Region: Mrr_cat; pfam04471 698968005042 Abi-like protein; Region: Abi_2; pfam07751 698968005043 GTP-binding protein LepA; Provisional; Region: PRK05433 698968005044 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 698968005045 G1 box; other site 698968005046 putative GEF interaction site [polypeptide binding]; other site 698968005047 GTP/Mg2+ binding site [chemical binding]; other site 698968005048 Switch I region; other site 698968005049 G2 box; other site 698968005050 G3 box; other site 698968005051 Switch II region; other site 698968005052 G4 box; other site 698968005053 G5 box; other site 698968005054 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 698968005055 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 698968005056 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 698968005057 PemK-like protein; Region: PemK; pfam02452 698968005058 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 698968005059 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698968005060 hypothetical protein; Validated; Region: PRK05629 698968005061 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 698968005062 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 698968005063 Competence protein; Region: Competence; pfam03772 698968005064 comEA protein; Region: comE; TIGR01259 698968005065 Helix-hairpin-helix motif; Region: HHH; pfam00633 698968005066 helix-hairpin-helix signature motif; other site 698968005067 EDD domain protein, DegV family; Region: DegV; TIGR00762 698968005068 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 698968005069 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698968005070 catalytic core [active] 698968005071 Oligomerisation domain; Region: Oligomerisation; cl00519 698968005072 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 698968005073 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 698968005074 active site 698968005075 (T/H)XGH motif; other site 698968005076 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 698968005077 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 698968005078 putative catalytic cysteine [active] 698968005079 gamma-glutamyl kinase; Provisional; Region: PRK05429 698968005080 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 698968005081 nucleotide binding site [chemical binding]; other site 698968005082 homotetrameric interface [polypeptide binding]; other site 698968005083 putative phosphate binding site [ion binding]; other site 698968005084 putative allosteric binding site; other site 698968005085 PUA domain; Region: PUA; pfam01472 698968005086 GTPase CgtA; Reviewed; Region: obgE; PRK12296 698968005087 GTP1/OBG; Region: GTP1_OBG; pfam01018 698968005088 Obg GTPase; Region: Obg; cd01898 698968005089 G1 box; other site 698968005090 GTP/Mg2+ binding site [chemical binding]; other site 698968005091 Switch I region; other site 698968005092 G2 box; other site 698968005093 G3 box; other site 698968005094 Switch II region; other site 698968005095 G4 box; other site 698968005096 G5 box; other site 698968005097 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 698968005098 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 698968005099 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 698968005100 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 698968005101 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698968005102 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 698968005103 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 698968005104 homodimer interface [polypeptide binding]; other site 698968005105 oligonucleotide binding site [chemical binding]; other site 698968005106 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 698968005107 active site 698968005108 multimer interface [polypeptide binding]; other site 698968005109 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 698968005110 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 698968005111 dimer interface [polypeptide binding]; other site 698968005112 active site 698968005113 CoA binding pocket [chemical binding]; other site 698968005114 hypothetical protein; Provisional; Region: PRK07483 698968005115 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698968005116 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698968005117 catalytic residue [active] 698968005118 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698968005119 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698968005120 active site 698968005121 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698968005122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968005123 putative substrate translocation pore; other site 698968005124 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698968005125 Resolvase, N terminal domain; Region: Resolvase; pfam00239 698968005126 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698968005127 Helix-turn-helix domain; Region: HTH_38; pfam13936 698968005128 Integrase core domain; Region: rve; pfam00665 698968005129 potential frameshift: common BLAST hit: gi|68535288|ref|YP_249993.1| transposase IS3510a 698968005130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698968005131 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698968005132 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 698968005133 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 698968005134 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698968005135 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 698968005136 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698968005137 active site 698968005138 HIGH motif; other site 698968005139 nucleotide binding site [chemical binding]; other site 698968005140 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698968005141 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 698968005142 active site 698968005143 KMSKS motif; other site 698968005144 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 698968005145 tRNA binding surface [nucleotide binding]; other site 698968005146 anticodon binding site; other site 698968005147 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 698968005148 malate dehydrogenase; Provisional; Region: PRK05442 698968005149 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 698968005150 NAD(P) binding site [chemical binding]; other site 698968005151 dimer interface [polypeptide binding]; other site 698968005152 malate binding site [chemical binding]; other site 698968005153 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698968005154 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698968005155 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 698968005156 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 698968005157 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 698968005158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968005159 Walker A motif; other site 698968005160 ATP binding site [chemical binding]; other site 698968005161 Walker B motif; other site 698968005162 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 698968005163 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698968005164 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698968005165 glutamine binding [chemical binding]; other site 698968005166 catalytic triad [active] 698968005167 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 698968005168 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698968005169 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 698968005170 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 698968005171 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698968005172 oligomer interface [polypeptide binding]; other site 698968005173 active site residues [active] 698968005174 Clp protease; Region: CLP_protease; pfam00574 698968005175 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698968005176 oligomer interface [polypeptide binding]; other site 698968005177 active site residues [active] 698968005178 trigger factor; Provisional; Region: tig; PRK01490 698968005179 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698968005180 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 698968005181 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 698968005182 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698968005183 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698968005184 catalytic residues [active] 698968005185 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 698968005186 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 698968005187 Zn binding site [ion binding]; other site 698968005188 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698968005189 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698968005190 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 698968005191 apolar tunnel; other site 698968005192 heme binding site [chemical binding]; other site 698968005193 dimerization interface [polypeptide binding]; other site 698968005194 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698968005195 active site 698968005196 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 698968005197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968005198 Walker A/P-loop; other site 698968005199 ATP binding site [chemical binding]; other site 698968005200 Q-loop/lid; other site 698968005201 ABC transporter signature motif; other site 698968005202 Walker B; other site 698968005203 D-loop; other site 698968005204 H-loop/switch region; other site 698968005205 ABC transporter; Region: ABC_tran_2; pfam12848 698968005206 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698968005207 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698968005208 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698968005209 dimer interface [polypeptide binding]; other site 698968005210 ssDNA binding site [nucleotide binding]; other site 698968005211 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698968005212 Copper resistance protein D; Region: CopD; pfam05425 698968005213 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 698968005214 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 698968005215 Carbon starvation protein CstA; Region: CstA; pfam02554 698968005216 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 698968005217 Protein of unknown function (DUF466); Region: DUF466; pfam04328 698968005218 putative transposase OrfB; Reviewed; Region: PHA02517 698968005219 HTH-like domain; Region: HTH_21; pfam13276 698968005220 Integrase core domain; Region: rve; pfam00665 698968005221 Integrase core domain; Region: rve_2; pfam13333 698968005222 Homeodomain-like domain; Region: HTH_23; cl17451 698968005223 Helix-turn-helix domain; Region: HTH_28; pfam13518 698968005224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968005225 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698968005226 putative substrate translocation pore; other site 698968005227 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 698968005228 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 698968005229 NADP binding site [chemical binding]; other site 698968005230 dimer interface [polypeptide binding]; other site 698968005231 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698968005232 classical (c) SDRs; Region: SDR_c; cd05233 698968005233 NAD(P) binding site [chemical binding]; other site 698968005234 active site 698968005235 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 698968005236 catalytic site [active] 698968005237 putative active site [active] 698968005238 putative substrate binding site [chemical binding]; other site 698968005239 dimer interface [polypeptide binding]; other site 698968005240 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698968005241 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698968005242 inhibitor site; inhibition site 698968005243 active site 698968005244 dimer interface [polypeptide binding]; other site 698968005245 catalytic residue [active] 698968005246 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 698968005247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698968005248 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 698968005249 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698968005250 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 698968005251 conserved cis-peptide bond; other site 698968005252 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 698968005253 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 698968005254 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698968005255 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 698968005256 catalytic triad [active] 698968005257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698968005258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698968005259 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 698968005260 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698968005261 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 698968005262 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698968005263 phosphate binding site [ion binding]; other site 698968005264 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 698968005265 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 698968005266 active site 2 [active] 698968005267 active site 1 [active] 698968005268 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 698968005269 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698968005270 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 698968005271 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 698968005272 putative NAD(P) binding site [chemical binding]; other site 698968005273 active site 698968005274 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 698968005275 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 698968005276 active site 698968005277 Glucitol operon activator protein (GutM); Region: GutM; cl01890 698968005278 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 698968005279 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 698968005280 active site 698968005281 dimerization interface [polypeptide binding]; other site 698968005282 ribonuclease PH; Reviewed; Region: rph; PRK00173 698968005283 Ribonuclease PH; Region: RNase_PH_bact; cd11362 698968005284 hexamer interface [polypeptide binding]; other site 698968005285 active site 698968005286 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 698968005287 glutamate racemase; Provisional; Region: PRK00865 698968005288 Rhomboid family; Region: Rhomboid; cl11446 698968005289 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 698968005290 putative active site pocket [active] 698968005291 cleavage site 698968005292 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 698968005293 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 698968005294 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 698968005295 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 698968005296 active site 698968005297 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 698968005298 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698968005299 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968005300 putative Mg++ binding site [ion binding]; other site 698968005301 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 698968005302 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698968005303 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698968005304 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698968005305 active site 698968005306 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 698968005307 dimer interface [polypeptide binding]; other site 698968005308 putative active site [active] 698968005309 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 698968005310 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 698968005311 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 698968005312 phosphoserine phosphatase SerB; Region: serB; TIGR00338 698968005313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968005314 motif II; other site 698968005315 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 698968005316 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 698968005317 D-pathway; other site 698968005318 Putative ubiquinol binding site [chemical binding]; other site 698968005319 Low-spin heme (heme b) binding site [chemical binding]; other site 698968005320 Putative water exit pathway; other site 698968005321 Binuclear center (heme o3/CuB) [ion binding]; other site 698968005322 K-pathway; other site 698968005323 Putative proton exit pathway; other site 698968005324 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698968005325 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698968005326 dimer interface [polypeptide binding]; other site 698968005327 putative radical transfer pathway; other site 698968005328 diiron center [ion binding]; other site 698968005329 tyrosyl radical; other site 698968005330 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 698968005331 Ferritin-like domain; Region: Ferritin; pfam00210 698968005332 ferroxidase diiron center [ion binding]; other site 698968005333 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 698968005334 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 698968005335 Class I ribonucleotide reductase; Region: RNR_I; cd01679 698968005336 active site 698968005337 dimer interface [polypeptide binding]; other site 698968005338 catalytic residues [active] 698968005339 effector binding site; other site 698968005340 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698968005341 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698968005342 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698968005343 catalytic residues [active] 698968005344 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 698968005345 active site lid residues [active] 698968005346 substrate binding pocket [chemical binding]; other site 698968005347 catalytic residues [active] 698968005348 substrate-Mg2+ binding site; other site 698968005349 aspartate-rich region 1; other site 698968005350 aspartate-rich region 2; other site 698968005351 phytoene desaturase; Region: crtI_fam; TIGR02734 698968005352 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698968005353 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 698968005354 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 698968005355 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 698968005356 homodimer interface [polypeptide binding]; other site 698968005357 NAD binding pocket [chemical binding]; other site 698968005358 ATP binding pocket [chemical binding]; other site 698968005359 Mg binding site [ion binding]; other site 698968005360 active-site loop [active] 698968005361 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 698968005362 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 698968005363 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 698968005364 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 698968005365 Predicted transcriptional regulator [Transcription]; Region: COG2345 698968005366 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 698968005367 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698968005368 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 698968005369 catalytic residues [active] 698968005370 Methylamine utilisation protein MauE; Region: MauE; pfam07291 698968005371 phosphoglucomutase; Validated; Region: PRK07564 698968005372 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 698968005373 active site 698968005374 substrate binding site [chemical binding]; other site 698968005375 metal binding site [ion binding]; metal-binding site 698968005376 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134 698968005377 CrcB-like protein; Region: CRCB; pfam02537 698968005378 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698968005379 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698968005380 FtsX-like permease family; Region: FtsX; pfam02687 698968005381 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698968005382 FtsX-like permease family; Region: FtsX; pfam02687 698968005383 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698968005384 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698968005385 Walker A/P-loop; other site 698968005386 ATP binding site [chemical binding]; other site 698968005387 Q-loop/lid; other site 698968005388 ABC transporter signature motif; other site 698968005389 Walker B; other site 698968005390 D-loop; other site 698968005391 H-loop/switch region; other site 698968005392 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698968005393 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698968005394 hinge; other site 698968005395 active site 698968005396 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 698968005397 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 698968005398 GAF domain; Region: GAF_2; pfam13185 698968005399 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698968005400 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698968005401 DNA binding residues [nucleotide binding] 698968005402 dimerization interface [polypeptide binding]; other site 698968005403 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698968005404 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698968005405 dimer interface [polypeptide binding]; other site 698968005406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968005407 catalytic residue [active] 698968005408 serine O-acetyltransferase; Region: cysE; TIGR01172 698968005409 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 698968005410 trimer interface [polypeptide binding]; other site 698968005411 active site 698968005412 substrate binding site [chemical binding]; other site 698968005413 CoA binding site [chemical binding]; other site 698968005414 Predicted acetyltransferase [General function prediction only]; Region: COG2388 698968005415 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 698968005416 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 698968005417 putative active site [active] 698968005418 metal binding site [ion binding]; metal-binding site 698968005419 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698968005420 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698968005421 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 698968005422 DNA methylase; Region: N6_N4_Mtase; pfam01555 698968005423 DNA methylase; Region: N6_N4_Mtase; pfam01555 698968005424 HTH-like domain; Region: HTH_21; pfam13276 698968005425 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 698968005426 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 698968005427 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698968005428 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698968005429 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 698968005430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968005431 Walker A/P-loop; other site 698968005432 ATP binding site [chemical binding]; other site 698968005433 Q-loop/lid; other site 698968005434 ABC transporter signature motif; other site 698968005435 Walker B; other site 698968005436 D-loop; other site 698968005437 H-loop/switch region; other site 698968005438 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 698968005439 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968005440 Walker A/P-loop; other site 698968005441 ATP binding site [chemical binding]; other site 698968005442 Q-loop/lid; other site 698968005443 ABC transporter signature motif; other site 698968005444 Walker B; other site 698968005445 D-loop; other site 698968005446 H-loop/switch region; other site 698968005447 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 698968005448 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 698968005449 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 698968005450 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 698968005451 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 698968005452 FMN binding site [chemical binding]; other site 698968005453 active site 698968005454 catalytic residues [active] 698968005455 substrate binding site [chemical binding]; other site 698968005456 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 698968005457 PhoU domain; Region: PhoU; pfam01895 698968005458 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 698968005459 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 698968005460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698968005461 Coenzyme A binding pocket [chemical binding]; other site 698968005462 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698968005463 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698968005464 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 698968005465 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 698968005466 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 698968005467 heme-binding site [chemical binding]; other site 698968005468 potential frameshift: common BLAST hit: gi|38234483|ref|NP_940250.1| 4-amino-4-deoxychorismate lyase 698968005469 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 698968005470 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 698968005471 substrate-cofactor binding pocket; other site 698968005472 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 698968005473 homodimer interface [polypeptide binding]; other site 698968005474 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 698968005475 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 698968005476 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698968005477 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 698968005478 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 698968005479 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 698968005480 dimerization interface [polypeptide binding]; other site 698968005481 putative ATP binding site [chemical binding]; other site 698968005482 amidophosphoribosyltransferase; Provisional; Region: PRK07847 698968005483 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 698968005484 active site 698968005485 tetramer interface [polypeptide binding]; other site 698968005486 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698968005487 active site 698968005488 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 698968005489 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 698968005490 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698968005491 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698968005492 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698968005493 dimer interface [polypeptide binding]; other site 698968005494 putative radical transfer pathway; other site 698968005495 diiron center [ion binding]; other site 698968005496 tyrosyl radical; other site 698968005497 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 698968005498 catalytic residues [active] 698968005499 dimer interface [polypeptide binding]; other site 698968005500 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 698968005501 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698968005502 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 698968005503 ATP binding site [chemical binding]; other site 698968005504 active site 698968005505 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 698968005506 substrate binding site [chemical binding]; other site 698968005507 adenylosuccinate lyase; Region: purB; TIGR00928 698968005508 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 698968005509 tetramer interface [polypeptide binding]; other site 698968005510 aspartate aminotransferase; Provisional; Region: PRK05764 698968005511 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698968005512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968005513 homodimer interface [polypeptide binding]; other site 698968005514 catalytic residue [active] 698968005515 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 698968005516 TrkA-N domain; Region: TrkA_N; pfam02254 698968005517 TrkA-C domain; Region: TrkA_C; pfam02080 698968005518 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 698968005519 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 698968005520 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 698968005521 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 698968005522 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 698968005523 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 698968005524 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 698968005525 nucleotide binding site/active site [active] 698968005526 HIT family signature motif; other site 698968005527 catalytic residue [active] 698968005528 PGAP1-like protein; Region: PGAP1; pfam07819 698968005529 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698968005530 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698968005531 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698968005532 dimerization interface [polypeptide binding]; other site 698968005533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698968005534 dimer interface [polypeptide binding]; other site 698968005535 phosphorylation site [posttranslational modification] 698968005536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698968005537 ATP binding site [chemical binding]; other site 698968005538 Mg2+ binding site [ion binding]; other site 698968005539 G-X-G motif; other site 698968005540 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698968005541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968005542 active site 698968005543 phosphorylation site [posttranslational modification] 698968005544 intermolecular recognition site; other site 698968005545 dimerization interface [polypeptide binding]; other site 698968005546 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698968005547 DNA binding site [nucleotide binding] 698968005548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968005549 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698968005550 putative substrate translocation pore; other site 698968005551 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698968005552 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698968005553 xanthine permease; Region: pbuX; TIGR03173 698968005554 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 698968005555 pyruvate dehydrogenase; Provisional; Region: PRK06546 698968005556 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 698968005557 PYR/PP interface [polypeptide binding]; other site 698968005558 dimer interface [polypeptide binding]; other site 698968005559 tetramer interface [polypeptide binding]; other site 698968005560 TPP binding site [chemical binding]; other site 698968005561 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698968005562 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 698968005563 TPP-binding site [chemical binding]; other site 698968005564 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698968005565 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 698968005566 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698968005567 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698968005568 Uncharacterized conserved protein [Function unknown]; Region: COG3610 698968005569 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 698968005570 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 698968005571 active site 698968005572 homotetramer interface [polypeptide binding]; other site 698968005573 META domain; Region: META; cl01245 698968005574 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 698968005575 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 698968005576 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698968005577 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698968005578 DNA binding site [nucleotide binding] 698968005579 domain linker motif; other site 698968005580 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 698968005581 putative dimerization interface [polypeptide binding]; other site 698968005582 putative ligand binding site [chemical binding]; other site 698968005583 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698968005584 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 698968005585 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698968005586 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 698968005587 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698968005588 active site 698968005589 HIGH motif; other site 698968005590 nucleotide binding site [chemical binding]; other site 698968005591 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698968005592 KMSKS motif; other site 698968005593 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698968005594 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 698968005595 homotrimer interaction site [polypeptide binding]; other site 698968005596 zinc binding site [ion binding]; other site 698968005597 CDP-binding sites; other site 698968005598 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 698968005599 substrate binding site; other site 698968005600 dimer interface; other site 698968005601 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 698968005602 DNA repair protein RadA; Provisional; Region: PRK11823 698968005603 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698968005604 Walker A motif; other site 698968005605 ATP binding site [chemical binding]; other site 698968005606 Walker B motif; other site 698968005607 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698968005608 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 698968005609 active site clefts [active] 698968005610 zinc binding site [ion binding]; other site 698968005611 dimer interface [polypeptide binding]; other site 698968005612 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698968005613 endonuclease III; Region: ENDO3c; smart00478 698968005614 minor groove reading motif; other site 698968005615 helix-hairpin-helix signature motif; other site 698968005616 substrate binding pocket [chemical binding]; other site 698968005617 active site 698968005618 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698968005619 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698968005620 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 698968005621 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 698968005622 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 698968005623 Clp amino terminal domain; Region: Clp_N; pfam02861 698968005624 Clp amino terminal domain; Region: Clp_N; pfam02861 698968005625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968005626 Walker A motif; other site 698968005627 ATP binding site [chemical binding]; other site 698968005628 Walker B motif; other site 698968005629 arginine finger; other site 698968005630 UvrB/uvrC motif; Region: UVR; pfam02151 698968005631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968005632 Walker A motif; other site 698968005633 ATP binding site [chemical binding]; other site 698968005634 Walker B motif; other site 698968005635 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698968005636 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 698968005637 oligomer interface [polypeptide binding]; other site 698968005638 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698968005639 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698968005640 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 698968005641 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698968005642 dimer interface [polypeptide binding]; other site 698968005643 putative anticodon binding site; other site 698968005644 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698968005645 motif 1; other site 698968005646 dimer interface [polypeptide binding]; other site 698968005647 active site 698968005648 motif 2; other site 698968005649 motif 3; other site 698968005650 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698968005651 YcaO-like family; Region: YcaO; pfam02624 698968005652 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698968005653 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698968005654 Walker A/P-loop; other site 698968005655 ATP binding site [chemical binding]; other site 698968005656 Q-loop/lid; other site 698968005657 ABC transporter signature motif; other site 698968005658 Walker B; other site 698968005659 D-loop; other site 698968005660 H-loop/switch region; other site 698968005661 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698968005662 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 698968005663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 698968005664 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698968005665 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698968005666 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698968005667 active site 698968005668 KMSKS motif; other site 698968005669 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 698968005670 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 698968005671 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 698968005672 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 698968005673 catalytic center binding site [active] 698968005674 ATP binding site [chemical binding]; other site 698968005675 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 698968005676 homooctamer interface [polypeptide binding]; other site 698968005677 active site 698968005678 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698968005679 dihydropteroate synthase; Region: DHPS; TIGR01496 698968005680 substrate binding pocket [chemical binding]; other site 698968005681 dimer interface [polypeptide binding]; other site 698968005682 inhibitor binding site; inhibition site 698968005683 Protein of unknown function, DUF393; Region: DUF393; pfam04134 698968005684 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 698968005685 homodecamer interface [polypeptide binding]; other site 698968005686 GTP cyclohydrolase I; Provisional; Region: PLN03044 698968005687 active site 698968005688 putative catalytic site residues [active] 698968005689 zinc binding site [ion binding]; other site 698968005690 GTP-CH-I/GFRP interaction surface; other site 698968005691 FtsH Extracellular; Region: FtsH_ext; pfam06480 698968005692 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 698968005693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968005694 Walker A motif; other site 698968005695 ATP binding site [chemical binding]; other site 698968005696 Walker B motif; other site 698968005697 arginine finger; other site 698968005698 Peptidase family M41; Region: Peptidase_M41; pfam01434 698968005699 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698968005700 active site 698968005701 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 698968005702 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 698968005703 Ligand Binding Site [chemical binding]; other site 698968005704 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 698968005705 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 698968005706 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 698968005707 dimer interface [polypeptide binding]; other site 698968005708 substrate binding site [chemical binding]; other site 698968005709 metal binding sites [ion binding]; metal-binding site 698968005710 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698968005711 active site residue [active] 698968005712 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698968005713 MarR family; Region: MarR_2; pfam12802 698968005714 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698968005715 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 698968005716 acyl-activating enzyme (AAE) consensus motif; other site 698968005717 AMP binding site [chemical binding]; other site 698968005718 active site 698968005719 CoA binding site [chemical binding]; other site 698968005720 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698968005721 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 698968005722 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698968005723 putative trimer interface [polypeptide binding]; other site 698968005724 putative CoA binding site [chemical binding]; other site 698968005725 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698968005726 putative trimer interface [polypeptide binding]; other site 698968005727 putative CoA binding site [chemical binding]; other site 698968005728 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698968005729 metal ion-dependent adhesion site (MIDAS); other site 698968005730 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698968005731 active site 698968005732 catalytic site [active] 698968005733 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698968005734 Secretory lipase; Region: LIP; pfam03583 698968005735 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698968005736 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 698968005737 Homeodomain-like domain; Region: HTH_23; cl17451 698968005738 Helix-turn-helix domain; Region: HTH_28; pfam13518 698968005739 putative transposase OrfB; Reviewed; Region: PHA02517 698968005740 HTH-like domain; Region: HTH_21; pfam13276 698968005741 Integrase core domain; Region: rve; pfam00665 698968005742 Integrase core domain; Region: rve_2; pfam13333 698968005743 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698968005744 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698968005745 ring oligomerisation interface [polypeptide binding]; other site 698968005746 ATP/Mg binding site [chemical binding]; other site 698968005747 stacking interactions; other site 698968005748 hinge regions; other site 698968005749 Fic/DOC family; Region: Fic; pfam02661 698968005750 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 698968005751 hypothetical protein; Reviewed; Region: PRK09588 698968005752 potential frameshift: common BLAST hit: gi|172041596|ref|YP_001801310.1| transposase for insertion sequence 698968005753 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698968005754 MULE transposase domain; Region: MULE; pfam10551 698968005755 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 698968005756 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 698968005757 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 698968005758 FMN binding site [chemical binding]; other site 698968005759 active site 698968005760 substrate binding site [chemical binding]; other site 698968005761 catalytic residue [active] 698968005762 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 698968005763 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698968005764 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698968005765 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968005766 Walker A/P-loop; other site 698968005767 ATP binding site [chemical binding]; other site 698968005768 Q-loop/lid; other site 698968005769 ABC transporter signature motif; other site 698968005770 Walker B; other site 698968005771 D-loop; other site 698968005772 H-loop/switch region; other site 698968005773 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698968005774 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 698968005775 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 698968005776 amidohydrolase; Region: amidohydrolases; TIGR01891 698968005777 metal binding site [ion binding]; metal-binding site 698968005778 AAA domain; Region: AAA_21; pfam13304 698968005779 Restriction endonuclease [Defense mechanisms]; Region: COG3587 698968005780 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968005781 ATP binding site [chemical binding]; other site 698968005782 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 698968005783 DNA methylase; Region: N6_N4_Mtase; pfam01555 698968005784 DNA methylase; Region: N6_N4_Mtase; cl17433 698968005785 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698968005786 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698968005787 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698968005788 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698968005789 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698968005790 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968005791 ATP binding site [chemical binding]; other site 698968005792 putative Mg++ binding site [ion binding]; other site 698968005793 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968005794 nucleotide binding region [chemical binding]; other site 698968005795 ATP-binding site [chemical binding]; other site 698968005796 Abi-like protein; Region: Abi_2; cl01988 698968005797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698968005798 Coenzyme A binding pocket [chemical binding]; other site 698968005799 HipA N-terminal domain; Region: Couple_hipA; pfam13657 698968005800 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 698968005801 HipA-like N-terminal domain; Region: HipA_N; pfam07805 698968005802 HipA-like C-terminal domain; Region: HipA_C; pfam07804 698968005803 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 698968005804 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 698968005805 HicB family; Region: HicB; pfam05534 698968005806 putative transposase OrfB; Reviewed; Region: PHA02517 698968005807 HTH-like domain; Region: HTH_21; pfam13276 698968005808 Integrase core domain; Region: rve; pfam00665 698968005809 Integrase core domain; Region: rve_2; pfam13333 698968005810 Helix-turn-helix domain; Region: HTH_28; pfam13518 698968005811 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 698968005812 potential frameshift: common BLAST hit: gi|227832249|ref|YP_002833956.1| transposase 698968005813 MULE transposase domain; Region: MULE; pfam10551 698968005814 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698968005815 MULE transposase domain; Region: MULE; pfam10551 698968005816 hypothetical protein; Provisional; Region: PRK07907 698968005817 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 698968005818 active site 698968005819 metal binding site [ion binding]; metal-binding site 698968005820 dimer interface [polypeptide binding]; other site 698968005821 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698968005822 carboxylate-amine ligase; Provisional; Region: PRK13517 698968005823 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 698968005824 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698968005825 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698968005826 active site 698968005827 catalytic residues [active] 698968005828 metal binding site [ion binding]; metal-binding site 698968005829 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698968005830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698968005831 Coenzyme A binding pocket [chemical binding]; other site 698968005832 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698968005833 putative catalytic site [active] 698968005834 putative metal binding site [ion binding]; other site 698968005835 putative phosphate binding site [ion binding]; other site 698968005836 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 698968005837 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 698968005838 putative active site [active] 698968005839 catalytic site [active] 698968005840 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 698968005841 putative active site [active] 698968005842 catalytic site [active] 698968005843 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698968005844 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698968005845 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968005846 Walker A/P-loop; other site 698968005847 ATP binding site [chemical binding]; other site 698968005848 Q-loop/lid; other site 698968005849 ABC transporter signature motif; other site 698968005850 Walker B; other site 698968005851 D-loop; other site 698968005852 H-loop/switch region; other site 698968005853 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 698968005854 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698968005855 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698968005856 substrate binding pocket [chemical binding]; other site 698968005857 membrane-bound complex binding site; other site 698968005858 hinge residues; other site 698968005859 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698968005860 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698968005861 active site 698968005862 ATP binding site [chemical binding]; other site 698968005863 substrate binding site [chemical binding]; other site 698968005864 activation loop (A-loop); other site 698968005865 propionate/acetate kinase; Provisional; Region: PRK12379 698968005866 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 698968005867 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 698968005868 ferredoxin-NADP+ reductase; Region: PLN02852 698968005869 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698968005870 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698968005871 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 698968005872 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698968005873 active site 698968005874 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698968005875 putative active site [active] 698968005876 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 698968005877 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 698968005878 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 698968005879 GDP-binding site [chemical binding]; other site 698968005880 ACT binding site; other site 698968005881 IMP binding site; other site 698968005882 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698968005883 conserved repeat domain; Region: B_ant_repeat; TIGR01451 698968005884 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 698968005885 Predicted membrane protein [Function unknown]; Region: COG4129 698968005886 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698968005887 chromosome segregation protein; Provisional; Region: PRK03918 698968005888 Predicted membrane protein [Function unknown]; Region: COG4129 698968005889 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698968005890 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698968005891 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698968005892 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698968005893 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 698968005894 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698968005895 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 698968005896 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698968005897 Transposase; Region: HTH_Tnp_1; pfam01527 698968005898 putative transporter; Provisional; Region: PRK09821 698968005899 GntP family permease; Region: GntP_permease; pfam02447 698968005900 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698968005901 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698968005902 NAD(P) binding site [chemical binding]; other site 698968005903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 698968005904 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698968005905 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698968005906 DNA-binding site [nucleotide binding]; DNA binding site 698968005907 FCD domain; Region: FCD; pfam07729 698968005908 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698968005909 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698968005910 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698968005911 potential frameshift: common BLAST hit: gi|68535552|ref|YP_250257.1| transposase IS3510c 698968005912 Cna protein B-type domain; Region: Cna_B; pfam05738 698968005913 Cna protein B-type domain; Region: Cna_B; pfam05738 698968005914 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 698968005915 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 698968005916 active site 698968005917 intersubunit interface [polypeptide binding]; other site 698968005918 zinc binding site [ion binding]; other site 698968005919 Na+ binding site [ion binding]; other site 698968005920 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 698968005921 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698968005922 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698968005923 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698968005924 active site 698968005925 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698968005926 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698968005927 active site residue [active] 698968005928 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698968005929 active site residue [active] 698968005930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698968005931 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 698968005932 Clp amino terminal domain; Region: Clp_N; pfam02861 698968005933 Clp amino terminal domain; Region: Clp_N; pfam02861 698968005934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968005935 Walker A motif; other site 698968005936 ATP binding site [chemical binding]; other site 698968005937 Walker B motif; other site 698968005938 arginine finger; other site 698968005939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968005940 Walker A motif; other site 698968005941 ATP binding site [chemical binding]; other site 698968005942 Walker B motif; other site 698968005943 arginine finger; other site 698968005944 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698968005945 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698968005946 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 698968005947 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698968005948 Walker A/P-loop; other site 698968005949 ATP binding site [chemical binding]; other site 698968005950 Q-loop/lid; other site 698968005951 ABC transporter signature motif; other site 698968005952 Walker B; other site 698968005953 D-loop; other site 698968005954 H-loop/switch region; other site 698968005955 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698968005956 EamA-like transporter family; Region: EamA; pfam00892 698968005957 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698968005958 EamA-like transporter family; Region: EamA; pfam00892 698968005959 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 698968005960 FAD binding pocket [chemical binding]; other site 698968005961 FAD binding motif [chemical binding]; other site 698968005962 phosphate binding motif [ion binding]; other site 698968005963 beta-alpha-beta structure motif; other site 698968005964 NAD binding pocket [chemical binding]; other site 698968005965 Predicted amidohydrolase [General function prediction only]; Region: COG0388 698968005966 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 698968005967 putative active site [active] 698968005968 catalytic triad [active] 698968005969 putative dimer interface [polypeptide binding]; other site 698968005970 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 698968005971 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 698968005972 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 698968005973 NAD binding site [chemical binding]; other site 698968005974 substrate binding site [chemical binding]; other site 698968005975 catalytic Zn binding site [ion binding]; other site 698968005976 tetramer interface [polypeptide binding]; other site 698968005977 structural Zn binding site [ion binding]; other site 698968005978 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698968005979 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698968005980 NAD(P) binding site [chemical binding]; other site 698968005981 catalytic residues [active] 698968005982 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 698968005983 DNA binding residues [nucleotide binding] 698968005984 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698968005985 putative dimer interface [polypeptide binding]; other site 698968005986 chaperone protein DnaJ; Provisional; Region: PRK14279 698968005987 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698968005988 HSP70 interaction site [polypeptide binding]; other site 698968005989 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698968005990 Zn binding sites [ion binding]; other site 698968005991 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698968005992 dimer interface [polypeptide binding]; other site 698968005993 heat shock protein GrpE; Provisional; Region: PRK14140 698968005994 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 698968005995 dimer interface [polypeptide binding]; other site 698968005996 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 698968005997 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 698968005998 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 698968005999 nucleotide binding site [chemical binding]; other site 698968006000 NEF interaction site [polypeptide binding]; other site 698968006001 SBD interface [polypeptide binding]; other site 698968006002 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698968006003 PAS domain; Region: PAS_9; pfam13426 698968006004 putative active site [active] 698968006005 heme pocket [chemical binding]; other site 698968006006 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698968006007 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698968006008 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698968006009 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698968006010 Walker A/P-loop; other site 698968006011 ATP binding site [chemical binding]; other site 698968006012 Q-loop/lid; other site 698968006013 ABC transporter signature motif; other site 698968006014 Walker B; other site 698968006015 D-loop; other site 698968006016 H-loop/switch region; other site 698968006017 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698968006018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968006019 dimer interface [polypeptide binding]; other site 698968006020 conserved gate region; other site 698968006021 putative PBP binding loops; other site 698968006022 ABC-ATPase subunit interface; other site 698968006023 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698968006024 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 698968006025 Walker A/P-loop; other site 698968006026 ATP binding site [chemical binding]; other site 698968006027 Q-loop/lid; other site 698968006028 ABC transporter signature motif; other site 698968006029 Walker B; other site 698968006030 D-loop; other site 698968006031 H-loop/switch region; other site 698968006032 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698968006033 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698968006034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968006035 dimer interface [polypeptide binding]; other site 698968006036 conserved gate region; other site 698968006037 putative PBP binding loops; other site 698968006038 ABC-ATPase subunit interface; other site 698968006039 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698968006040 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 698968006041 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698968006042 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698968006043 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 698968006044 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 698968006045 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 698968006046 dimerization interface [polypeptide binding]; other site 698968006047 ATP binding site [chemical binding]; other site 698968006048 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 698968006049 dimerization interface [polypeptide binding]; other site 698968006050 ATP binding site [chemical binding]; other site 698968006051 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 698968006052 putative active site [active] 698968006053 catalytic triad [active] 698968006054 nucleosidase; Provisional; Region: PRK05634 698968006055 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 698968006056 ferredoxin-NADP+ reductase; Region: PLN02852 698968006057 Permease; Region: Permease; cl00510 698968006058 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698968006059 4Fe-4S binding domain; Region: Fer4; cl02805 698968006060 Cysteine-rich domain; Region: CCG; pfam02754 698968006061 Cysteine-rich domain; Region: CCG; pfam02754 698968006062 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 698968006063 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698968006064 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 698968006065 putative NAD(P) binding site [chemical binding]; other site 698968006066 catalytic Zn binding site [ion binding]; other site 698968006067 aminotransferase AlaT; Validated; Region: PRK09265 698968006068 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698968006069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968006070 homodimer interface [polypeptide binding]; other site 698968006071 catalytic residue [active] 698968006072 YibE/F-like protein; Region: YibE_F; pfam07907 698968006073 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 698968006074 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 698968006075 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698968006076 dimer interface [polypeptide binding]; other site 698968006077 putative anticodon binding site; other site 698968006078 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698968006079 motif 1; other site 698968006080 dimer interface [polypeptide binding]; other site 698968006081 active site 698968006082 motif 2; other site 698968006083 motif 3; other site 698968006084 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698968006085 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 698968006086 Protein of unknown function (DUF998); Region: DUF998; pfam06197 698968006087 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 698968006088 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 698968006089 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 698968006090 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698968006091 trimer interface [polypeptide binding]; other site 698968006092 active site 698968006093 Prophage antirepressor [Transcription]; Region: COG3617 698968006094 BRO family, N-terminal domain; Region: Bro-N; smart01040 698968006095 Abi-like protein; Region: Abi_2; cl01988 698968006096 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 698968006097 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698968006098 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698968006099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968006100 Walker A/P-loop; other site 698968006101 ATP binding site [chemical binding]; other site 698968006102 Q-loop/lid; other site 698968006103 ABC transporter signature motif; other site 698968006104 Walker B; other site 698968006105 D-loop; other site 698968006106 H-loop/switch region; other site 698968006107 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698968006108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968006109 Walker A/P-loop; other site 698968006110 ATP binding site [chemical binding]; other site 698968006111 Q-loop/lid; other site 698968006112 ABC transporter signature motif; other site 698968006113 Walker B; other site 698968006114 D-loop; other site 698968006115 H-loop/switch region; other site 698968006116 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 698968006117 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 698968006118 active site 698968006119 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 698968006120 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698968006121 Condensation domain; Region: Condensation; pfam00668 698968006122 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698968006123 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698968006124 Condensation domain; Region: Condensation; pfam00668 698968006125 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698968006126 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698968006127 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698968006128 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 698968006129 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698968006130 Condensation domain; Region: Condensation; pfam00668 698968006131 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698968006132 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 698968006133 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 698968006134 acyl-activating enzyme (AAE) consensus motif; other site 698968006135 AMP binding site [chemical binding]; other site 698968006136 Condensation domain; Region: Condensation; pfam00668 698968006137 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698968006138 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698968006139 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698968006140 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698968006141 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 698968006142 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698968006143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968006144 conserved gate region; other site 698968006145 putative PBP binding loops; other site 698968006146 ABC-ATPase subunit interface; other site 698968006147 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698968006148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698968006149 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698968006150 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 698968006151 Walker A/P-loop; other site 698968006152 ATP binding site [chemical binding]; other site 698968006153 Q-loop/lid; other site 698968006154 ABC transporter signature motif; other site 698968006155 Walker B; other site 698968006156 D-loop; other site 698968006157 H-loop/switch region; other site 698968006158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968006159 Walker A/P-loop; other site 698968006160 ATP binding site [chemical binding]; other site 698968006161 Q-loop/lid; other site 698968006162 ABC transporter signature motif; other site 698968006163 Walker B; other site 698968006164 D-loop; other site 698968006165 H-loop/switch region; other site 698968006166 metabolite-proton symporter; Region: 2A0106; TIGR00883 698968006167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968006168 putative substrate translocation pore; other site 698968006169 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698968006170 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 698968006171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968006172 putative substrate translocation pore; other site 698968006173 YwiC-like protein; Region: YwiC; pfam14256 698968006174 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698968006175 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698968006176 VanW like protein; Region: VanW; pfam04294 698968006177 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 698968006178 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 698968006179 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 698968006180 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698968006181 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698968006182 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698968006183 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698968006184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968006185 S-adenosylmethionine binding site [chemical binding]; other site 698968006186 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 698968006187 active site 698968006188 substrate-binding site [chemical binding]; other site 698968006189 metal-binding site [ion binding] 698968006190 GTP binding site [chemical binding]; other site 698968006191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968006192 S-adenosylmethionine binding site [chemical binding]; other site 698968006193 LabA_like proteins; Region: LabA_like; cd06167 698968006194 putative metal binding site [ion binding]; other site 698968006195 MMPL family; Region: MMPL; pfam03176 698968006196 Protein of unknown function (DUF496); Region: DUF496; cl09955 698968006197 MMPL family; Region: MMPL; pfam03176 698968006198 Predicted integral membrane protein [Function unknown]; Region: COG0392 698968006199 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 698968006200 Cna protein B-type domain; Region: Cna_B; pfam05738 698968006201 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698968006202 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698968006203 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698968006204 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698968006205 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 698968006206 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 698968006207 active site 698968006208 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 698968006209 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698968006210 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 698968006211 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 698968006212 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 698968006213 acyl-activating enzyme (AAE) consensus motif; other site 698968006214 active site 698968006215 Cutinase; Region: Cutinase; pfam01083 698968006216 Putative esterase; Region: Esterase; pfam00756 698968006217 S-formylglutathione hydrolase; Region: PLN02442 698968006218 LGFP repeat; Region: LGFP; pfam08310 698968006219 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698968006220 LGFP repeat; Region: LGFP; pfam08310 698968006221 LGFP repeat; Region: LGFP; pfam08310 698968006222 Predicted esterase [General function prediction only]; Region: COG0627 698968006223 S-formylglutathione hydrolase; Region: PLN02442 698968006224 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 698968006225 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 698968006226 UbiA prenyltransferase family; Region: UbiA; pfam01040 698968006227 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698968006228 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698968006229 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698968006230 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698968006231 active site 698968006232 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698968006233 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698968006234 NAD(P) binding site [chemical binding]; other site 698968006235 catalytic residues [active] 698968006236 BCCT family transporter; Region: BCCT; cl00569 698968006237 choline dehydrogenase; Validated; Region: PRK02106 698968006238 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698968006239 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 698968006240 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698968006241 UDP-galactopyranose mutase; Region: GLF; pfam03275 698968006242 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 698968006243 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698968006244 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968006245 ABC transporter signature motif; other site 698968006246 Walker B; other site 698968006247 D-loop; other site 698968006248 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698968006249 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698968006250 amidase catalytic site [active] 698968006251 Zn binding residues [ion binding]; other site 698968006252 substrate binding site [chemical binding]; other site 698968006253 LGFP repeat; Region: LGFP; pfam08310 698968006254 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 698968006255 HTH-like domain; Region: HTH_21; pfam13276 698968006256 Integrase core domain; Region: rve; pfam00665 698968006257 Protein P3 of Potyviral polyprotein; Region: Potyvirid-P3; pfam13608 698968006258 glycerol kinase; Provisional; Region: glpK; PRK00047 698968006259 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698968006260 nucleotide binding site [chemical binding]; other site 698968006261 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 698968006262 amphipathic channel; other site 698968006263 Asn-Pro-Ala signature motifs; other site 698968006264 FAD dependent oxidoreductase; Region: DAO; pfam01266 698968006265 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698968006266 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698968006267 putative acyl-acceptor binding pocket; other site 698968006268 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968006269 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698968006270 active site 698968006271 motif I; other site 698968006272 motif II; other site 698968006273 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968006274 seryl-tRNA synthetase; Provisional; Region: PRK05431 698968006275 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 698968006276 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 698968006277 dimer interface [polypeptide binding]; other site 698968006278 active site 698968006279 motif 1; other site 698968006280 motif 2; other site 698968006281 motif 3; other site 698968006282 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698968006283 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698968006284 DNA-binding site [nucleotide binding]; DNA binding site 698968006285 UTRA domain; Region: UTRA; pfam07702 698968006286 Septum formation; Region: Septum_form; pfam13845 698968006287 Septum formation; Region: Septum_form; pfam13845 698968006288 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 698968006289 AAA domain; Region: AAA_14; pfam13173 698968006290 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 698968006291 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698968006292 catalytic core [active] 698968006293 prephenate dehydratase; Provisional; Region: PRK11898 698968006294 Prephenate dehydratase; Region: PDT; pfam00800 698968006295 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 698968006296 putative L-Phe binding site [chemical binding]; other site 698968006297 Amidase; Region: Amidase; cl11426 698968006298 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698968006299 CAAX protease self-immunity; Region: Abi; pfam02517 698968006300 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 698968006301 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698968006302 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698968006303 amino acid carrier protein; Region: agcS; TIGR00835 698968006304 Acyltransferase family; Region: Acyl_transf_3; pfam01757 698968006305 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 698968006306 catalytic triad [active] 698968006307 catalytic triad [active] 698968006308 oxyanion hole [active] 698968006309 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698968006310 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 698968006311 putative active site [active] 698968006312 catalytic site [active] 698968006313 putative metal binding site [ion binding]; other site 698968006314 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 698968006315 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 698968006316 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698968006317 NAD binding site [chemical binding]; other site 698968006318 dimer interface [polypeptide binding]; other site 698968006319 substrate binding site [chemical binding]; other site 698968006320 quinolinate synthetase; Provisional; Region: PRK09375 698968006321 L-aspartate oxidase; Provisional; Region: PRK06175 698968006322 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 698968006323 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 698968006324 dimerization interface [polypeptide binding]; other site 698968006325 active site 698968006326 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 698968006327 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 698968006328 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 698968006329 Predicted flavoprotein [General function prediction only]; Region: COG0431 698968006330 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698968006331 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 698968006332 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 698968006333 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698968006334 Lsr2; Region: Lsr2; pfam11774 698968006335 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698968006336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968006337 active site 698968006338 phosphorylation site [posttranslational modification] 698968006339 intermolecular recognition site; other site 698968006340 dimerization interface [polypeptide binding]; other site 698968006341 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698968006342 DNA binding residues [nucleotide binding] 698968006343 dimerization interface [polypeptide binding]; other site 698968006344 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698968006345 Histidine kinase; Region: HisKA_3; pfam07730 698968006346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698968006347 ATP binding site [chemical binding]; other site 698968006348 Mg2+ binding site [ion binding]; other site 698968006349 G-X-G motif; other site 698968006350 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 698968006351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968006352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968006353 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 698968006354 active site 698968006355 catalytic site [active] 698968006356 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 698968006357 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 698968006358 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698968006359 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698968006360 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698968006361 Ligand Binding Site [chemical binding]; other site 698968006362 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698968006363 Ligand Binding Site [chemical binding]; other site 698968006364 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 698968006365 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698968006366 probable active site [active] 698968006367 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698968006368 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968006369 Walker A/P-loop; other site 698968006370 ATP binding site [chemical binding]; other site 698968006371 Q-loop/lid; other site 698968006372 ABC transporter signature motif; other site 698968006373 Walker B; other site 698968006374 D-loop; other site 698968006375 H-loop/switch region; other site 698968006376 Predicted transcriptional regulators [Transcription]; Region: COG1725 698968006377 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698968006378 DNA-binding site [nucleotide binding]; DNA binding site 698968006379 LabA_like proteins; Region: LabA_like; cd06167 698968006380 putative metal binding site [ion binding]; other site 698968006381 Uncharacterized conserved protein [Function unknown]; Region: COG1432 698968006382 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698968006383 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698968006384 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698968006385 catalytic residues [active] 698968006386 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698968006387 metal-binding site [ion binding] 698968006388 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698968006389 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698968006390 metal-binding site [ion binding] 698968006391 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698968006392 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698968006393 benzoate transport; Region: 2A0115; TIGR00895 698968006394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968006395 putative substrate translocation pore; other site 698968006396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968006397 replicative DNA helicase; Provisional; Region: PRK05636 698968006398 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 698968006399 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 698968006400 Walker A motif; other site 698968006401 ATP binding site [chemical binding]; other site 698968006402 Walker B motif; other site 698968006403 DNA binding loops [nucleotide binding] 698968006404 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 698968006405 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 698968006406 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 698968006407 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698968006408 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698968006409 dimer interface [polypeptide binding]; other site 698968006410 ssDNA binding site [nucleotide binding]; other site 698968006411 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698968006412 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 698968006413 Predicted integral membrane protein [Function unknown]; Region: COG5650 698968006414 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698968006415 Transglycosylase; Region: Transgly; pfam00912 698968006416 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698968006417 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698968006418 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698968006419 Ligand Binding Site [chemical binding]; other site 698968006420 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698968006421 Ligand Binding Site [chemical binding]; other site 698968006422 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698968006423 classical (c) SDRs; Region: SDR_c; cd05233 698968006424 NAD(P) binding site [chemical binding]; other site 698968006425 active site 698968006426 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698968006427 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698968006428 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 698968006429 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 698968006430 active site residue [active] 698968006431 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 698968006432 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698968006433 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 698968006434 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 698968006435 dimerization interface [polypeptide binding]; other site 698968006436 DPS ferroxidase diiron center [ion binding]; other site 698968006437 ion pore; other site 698968006438 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698968006439 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 698968006440 putative DNA binding site [nucleotide binding]; other site 698968006441 catalytic residue [active] 698968006442 putative H2TH interface [polypeptide binding]; other site 698968006443 putative catalytic residues [active] 698968006444 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698968006445 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698968006446 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 698968006447 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 698968006448 putative substrate binding site [chemical binding]; other site 698968006449 putative ATP binding site [chemical binding]; other site 698968006450 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 698968006451 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 698968006452 active site 698968006453 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698968006454 AAA domain; Region: AAA_31; pfam13614 698968006455 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698968006456 P-loop; other site 698968006457 Magnesium ion binding site [ion binding]; other site 698968006458 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698968006459 Magnesium ion binding site [ion binding]; other site 698968006460 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698968006461 Divergent AAA domain; Region: AAA_4; pfam04326 698968006462 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698968006463 Divergent AAA domain; Region: AAA_4; pfam04326 698968006464 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698968006465 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698968006466 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698968006467 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968006468 ATP binding site [chemical binding]; other site 698968006469 putative Mg++ binding site [ion binding]; other site 698968006470 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 698968006471 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698968006472 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698968006473 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698968006474 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698968006475 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698968006476 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 698968006477 HsdM N-terminal domain; Region: HsdM_N; pfam12161 698968006478 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 698968006479 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698968006480 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 698968006481 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698968006482 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 698968006483 DNA binding residues [nucleotide binding] 698968006484 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 698968006485 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 698968006486 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 698968006487 Uncharacterized conserved protein [Function unknown]; Region: COG3410 698968006488 Fic family protein [Function unknown]; Region: COG3177 698968006489 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698968006490 Fic/DOC family; Region: Fic; pfam02661 698968006491 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 698968006492 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 698968006493 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 698968006494 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 698968006495 E-class dimer interface [polypeptide binding]; other site 698968006496 P-class dimer interface [polypeptide binding]; other site 698968006497 active site 698968006498 Cu2+ binding site [ion binding]; other site 698968006499 Zn2+ binding site [ion binding]; other site 698968006500 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 698968006501 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698968006502 active site 698968006503 HIGH motif; other site 698968006504 nucleotide binding site [chemical binding]; other site 698968006505 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698968006506 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698968006507 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698968006508 active site 698968006509 KMSKS motif; other site 698968006510 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 698968006511 tRNA binding surface [nucleotide binding]; other site 698968006512 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698968006513 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698968006514 Walker A/P-loop; other site 698968006515 ATP binding site [chemical binding]; other site 698968006516 Q-loop/lid; other site 698968006517 ABC transporter signature motif; other site 698968006518 Walker B; other site 698968006519 D-loop; other site 698968006520 H-loop/switch region; other site 698968006521 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698968006522 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698968006523 Histidine kinase; Region: HisKA_3; pfam07730 698968006524 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698968006525 ATP binding site [chemical binding]; other site 698968006526 G-X-G motif; other site 698968006527 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698968006528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968006529 active site 698968006530 phosphorylation site [posttranslational modification] 698968006531 intermolecular recognition site; other site 698968006532 dimerization interface [polypeptide binding]; other site 698968006533 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698968006534 DNA binding residues [nucleotide binding] 698968006535 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698968006536 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698968006537 Predicted membrane protein [Function unknown]; Region: COG1511 698968006538 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698968006539 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698968006540 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698968006541 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698968006542 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698968006543 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698968006544 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 698968006545 NAD(P) binding site [chemical binding]; other site 698968006546 catalytic residues [active] 698968006547 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698968006548 active site 698968006549 phosphorylation site [posttranslational modification] 698968006550 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 698968006551 active site 698968006552 P-loop; other site 698968006553 phosphorylation site [posttranslational modification] 698968006554 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 698968006555 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 698968006556 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 698968006557 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 698968006558 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 698968006559 active site 698968006560 active pocket/dimerization site; other site 698968006561 phosphorylation site [posttranslational modification] 698968006562 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698968006563 dimerization domain swap beta strand [polypeptide binding]; other site 698968006564 regulatory protein interface [polypeptide binding]; other site 698968006565 active site 698968006566 regulatory phosphorylation site [posttranslational modification]; other site 698968006567 Predicted ATPases [General function prediction only]; Region: COG1106 698968006568 Putative esterase; Region: Esterase; pfam00756 698968006569 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 698968006570 active site 698968006571 Cobalt transport protein; Region: CbiQ; cl00463 698968006572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968006573 ABC transporter signature motif; other site 698968006574 Walker B; other site 698968006575 D-loop; other site 698968006576 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698968006577 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698968006578 Walker A/P-loop; other site 698968006579 ATP binding site [chemical binding]; other site 698968006580 Q-loop/lid; other site 698968006581 ABC transporter signature motif; other site 698968006582 Walker B; other site 698968006583 D-loop; other site 698968006584 H-loop/switch region; other site 698968006585 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 698968006586 active site 698968006587 catalytic residues [active] 698968006588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 698968006589 hypothetical protein; Provisional; Region: PRK13663 698968006590 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698968006591 putative active site [active] 698968006592 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698968006593 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698968006594 SdpI/YhfL protein family; Region: SdpI; pfam13630 698968006595 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698968006596 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698968006597 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968006598 catalytic residue [active] 698968006599 anthranilate synthase component I; Provisional; Region: PRK13564 698968006600 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 698968006601 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698968006602 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698968006603 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698968006604 glutamine binding [chemical binding]; other site 698968006605 catalytic triad [active] 698968006606 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 698968006607 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698968006608 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698968006609 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 698968006610 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698968006611 active site 698968006612 ribulose/triose binding site [chemical binding]; other site 698968006613 phosphate binding site [ion binding]; other site 698968006614 substrate (anthranilate) binding pocket [chemical binding]; other site 698968006615 product (indole) binding pocket [chemical binding]; other site 698968006616 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 698968006617 active site 698968006618 Protein of unknown function (DUF454); Region: DUF454; cl01063 698968006619 pantoate--beta-alanine ligase; Region: panC; TIGR00018 698968006620 Pantoate-beta-alanine ligase; Region: PanC; cd00560 698968006621 active site 698968006622 ATP-binding site [chemical binding]; other site 698968006623 pantoate-binding site; other site 698968006624 HXXH motif; other site 698968006625 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 698968006626 oligomerization interface [polypeptide binding]; other site 698968006627 active site 698968006628 metal binding site [ion binding]; metal-binding site 698968006629 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698968006630 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698968006631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968006632 catalytic residue [active] 698968006633 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 698968006634 substrate binding site [chemical binding]; other site 698968006635 active site 698968006636 catalytic residues [active] 698968006637 heterodimer interface [polypeptide binding]; other site 698968006638 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698968006639 iron-sulfur cluster [ion binding]; other site 698968006640 [2Fe-2S] cluster binding site [ion binding]; other site 698968006641 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 698968006642 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698968006643 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 698968006644 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 698968006645 hypothetical protein; Validated; Region: PRK00228 698968006646 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 698968006647 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 698968006648 active site 698968006649 NTP binding site [chemical binding]; other site 698968006650 metal binding triad [ion binding]; metal-binding site 698968006651 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 698968006652 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698968006653 Zn2+ binding site [ion binding]; other site 698968006654 Mg2+ binding site [ion binding]; other site 698968006655 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 698968006656 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698968006657 active site 698968006658 Ap6A binding site [chemical binding]; other site 698968006659 nudix motif; other site 698968006660 metal binding site [ion binding]; metal-binding site 698968006661 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 698968006662 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 698968006663 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 698968006664 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698968006665 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698968006666 DNA binding residues [nucleotide binding] 698968006667 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 698968006668 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698968006669 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698968006670 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698968006671 catalytic residues [active] 698968006672 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698968006673 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698968006674 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 698968006675 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 698968006676 active site 698968006677 metal binding site [ion binding]; metal-binding site 698968006678 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 698968006679 ParB-like nuclease domain; Region: ParBc; pfam02195 698968006680 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698968006681 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698968006682 P-loop; other site 698968006683 Magnesium ion binding site [ion binding]; other site 698968006684 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698968006685 Magnesium ion binding site [ion binding]; other site 698968006686 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 698968006687 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 698968006688 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 698968006689 ribonuclease P; Reviewed; Region: rnpA; PRK03459 698968006690 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399