-- dump date 20140619_051013 -- class Genbank::misc_feature -- table misc_feature_note -- id note 698969000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698969000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 698969000003 Walker A motif; other site 698969000004 ATP binding site [chemical binding]; other site 698969000005 Walker B motif; other site 698969000006 arginine finger; other site 698969000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 698969000008 DnaA box-binding interface [nucleotide binding]; other site 698969000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 698969000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 698969000011 putative DNA binding surface [nucleotide binding]; other site 698969000012 dimer interface [polypeptide binding]; other site 698969000013 beta-clamp/clamp loader binding surface; other site 698969000014 beta-clamp/translesion DNA polymerase binding surface; other site 698969000015 recombination protein F; Reviewed; Region: recF; PRK00064 698969000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 698969000017 Walker A/P-loop; other site 698969000018 ATP binding site [chemical binding]; other site 698969000019 Q-loop/lid; other site 698969000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969000021 ABC transporter signature motif; other site 698969000022 Walker B; other site 698969000023 D-loop; other site 698969000024 H-loop/switch region; other site 698969000025 hypothetical protein; Provisional; Region: PRK00111 698969000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 698969000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698969000028 ATP binding site [chemical binding]; other site 698969000029 Mg2+ binding site [ion binding]; other site 698969000030 G-X-G motif; other site 698969000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698969000032 anchoring element; other site 698969000033 dimer interface [polypeptide binding]; other site 698969000034 ATP binding site [chemical binding]; other site 698969000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 698969000036 active site 698969000037 putative metal-binding site [ion binding]; other site 698969000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698969000039 DNA gyrase subunit A; Validated; Region: PRK05560 698969000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 698969000041 CAP-like domain; other site 698969000042 active site 698969000043 primary dimer interface [polypeptide binding]; other site 698969000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698969000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698969000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698969000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698969000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698969000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698969000050 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 698969000051 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698969000052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698969000053 DNA-binding site [nucleotide binding]; DNA binding site 698969000054 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698969000055 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698969000056 L-lactate permease; Region: Lactate_perm; cl00701 698969000057 Cadherin repeat-like domain; Region: CA_like; cl15786 698969000058 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698969000059 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698969000060 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 698969000061 Walker A/P-loop; other site 698969000062 ATP binding site [chemical binding]; other site 698969000063 Q-loop/lid; other site 698969000064 ABC transporter signature motif; other site 698969000065 Walker B; other site 698969000066 D-loop; other site 698969000067 H-loop/switch region; other site 698969000068 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969000069 Walker A/P-loop; other site 698969000070 ATP binding site [chemical binding]; other site 698969000071 ABC transporter; Region: ABC_tran; pfam00005 698969000072 Q-loop/lid; other site 698969000073 ABC transporter signature motif; other site 698969000074 Walker B; other site 698969000075 D-loop; other site 698969000076 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698969000077 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 698969000078 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698969000079 putative ligand binding site [chemical binding]; other site 698969000080 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698969000081 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698969000082 TM-ABC transporter signature motif; other site 698969000083 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698969000084 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698969000085 Walker A/P-loop; other site 698969000086 ATP binding site [chemical binding]; other site 698969000087 Q-loop/lid; other site 698969000088 ABC transporter signature motif; other site 698969000089 Walker B; other site 698969000090 D-loop; other site 698969000091 H-loop/switch region; other site 698969000092 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698969000093 active site 698969000094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698969000095 Helix-turn-helix domain; Region: HTH_28; pfam13518 698969000096 Integrase core domain; Region: rve_3; cl15866 698969000097 Rhomboid family; Region: Rhomboid; pfam01694 698969000098 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 698969000099 ThiC-associated domain; Region: ThiC-associated; pfam13667 698969000100 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 698969000101 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698969000102 thiamine phosphate binding site [chemical binding]; other site 698969000103 active site 698969000104 pyrophosphate binding site [ion binding]; other site 698969000105 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698969000106 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 698969000107 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 698969000108 ThiS interaction site; other site 698969000109 putative active site [active] 698969000110 tetramer interface [polypeptide binding]; other site 698969000111 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 698969000112 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698969000113 ATP binding site [chemical binding]; other site 698969000114 substrate interface [chemical binding]; other site 698969000115 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698969000116 active site residue [active] 698969000117 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 698969000118 dimer interface [polypeptide binding]; other site 698969000119 substrate binding site [chemical binding]; other site 698969000120 ATP binding site [chemical binding]; other site 698969000121 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698969000122 helicase Cas3; Provisional; Region: PRK09694 698969000123 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 698969000124 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698969000125 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 698969000126 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 698969000127 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 698969000128 CT1975-like protein; Region: Cas_CT1975; pfam09344 698969000129 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 698969000130 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 698969000131 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 698969000132 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 698969000133 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 698969000134 putative septation inhibitor protein; Reviewed; Region: PRK00159 698969000135 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698969000136 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698969000137 active site 698969000138 ATP binding site [chemical binding]; other site 698969000139 substrate binding site [chemical binding]; other site 698969000140 activation loop (A-loop); other site 698969000141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698969000142 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698969000143 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698969000144 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698969000145 PASTA domain; Region: PASTA; pfam03793 698969000146 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698969000147 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698969000148 active site 698969000149 ATP binding site [chemical binding]; other site 698969000150 substrate binding site [chemical binding]; other site 698969000151 activation loop (A-loop); other site 698969000152 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698969000153 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698969000154 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698969000155 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 698969000156 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 698969000157 Protein phosphatase 2C; Region: PP2C; pfam00481 698969000158 active site 698969000159 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698969000160 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698969000161 phosphopeptide binding site; other site 698969000162 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 698969000163 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698969000164 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698969000165 phosphopeptide binding site; other site 698969000166 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698969000167 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698969000168 non-specific DNA binding site [nucleotide binding]; other site 698969000169 salt bridge; other site 698969000170 sequence-specific DNA binding site [nucleotide binding]; other site 698969000171 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 698969000172 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 698969000173 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 698969000174 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698969000175 Walker A/P-loop; other site 698969000176 ATP binding site [chemical binding]; other site 698969000177 Q-loop/lid; other site 698969000178 ABC transporter signature motif; other site 698969000179 Walker B; other site 698969000180 D-loop; other site 698969000181 H-loop/switch region; other site 698969000182 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698969000183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698969000184 active site 698969000185 phosphorylation site [posttranslational modification] 698969000186 intermolecular recognition site; other site 698969000187 dimerization interface [polypeptide binding]; other site 698969000188 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698969000189 DNA binding residues [nucleotide binding] 698969000190 dimerization interface [polypeptide binding]; other site 698969000191 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698969000192 Histidine kinase; Region: HisKA_3; pfam07730 698969000193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698969000194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698969000195 dimer interface [polypeptide binding]; other site 698969000196 conserved gate region; other site 698969000197 putative PBP binding loops; other site 698969000198 ABC-ATPase subunit interface; other site 698969000199 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698969000200 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 698969000201 Walker A/P-loop; other site 698969000202 ATP binding site [chemical binding]; other site 698969000203 Q-loop/lid; other site 698969000204 ABC transporter signature motif; other site 698969000205 Walker B; other site 698969000206 D-loop; other site 698969000207 H-loop/switch region; other site 698969000208 Anti-sigma-K factor rskA; Region: RskA; pfam10099 698969000209 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 698969000210 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698969000211 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698969000212 DNA binding residues [nucleotide binding] 698969000213 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698969000214 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698969000215 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 698969000216 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698969000217 catalytic residues [active] 698969000218 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 698969000219 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698969000220 DNA binding residues [nucleotide binding] 698969000221 dimer interface [polypeptide binding]; other site 698969000222 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 698969000223 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 698969000224 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 698969000225 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 698969000226 putative metal binding site [ion binding]; other site 698969000227 biotin synthase; Validated; Region: PRK06256 698969000228 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698969000229 FeS/SAM binding site; other site 698969000230 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698969000231 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 698969000232 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 698969000233 putative ligand binding residues [chemical binding]; other site 698969000234 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698969000235 ABC-ATPase subunit interface; other site 698969000236 dimer interface [polypeptide binding]; other site 698969000237 putative PBP binding regions; other site 698969000238 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698969000239 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698969000240 Walker A/P-loop; other site 698969000241 ATP binding site [chemical binding]; other site 698969000242 Q-loop/lid; other site 698969000243 ABC transporter signature motif; other site 698969000244 Walker B; other site 698969000245 D-loop; other site 698969000246 H-loop/switch region; other site 698969000247 Uncharacterized conserved protein [Function unknown]; Region: COG5646 698969000248 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 698969000249 DNA photolyase; Region: DNA_photolyase; pfam00875 698969000250 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 698969000251 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 698969000252 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 698969000253 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 698969000254 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 698969000255 Lipase (class 2); Region: Lipase_2; pfam01674 698969000256 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 698969000257 dimer interface [polypeptide binding]; other site 698969000258 FMN binding site [chemical binding]; other site 698969000259 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698969000260 Divergent AAA domain; Region: AAA_4; pfam04326 698969000261 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698969000262 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698969000263 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 698969000264 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 698969000265 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 698969000266 trimer interface [polypeptide binding]; other site 698969000267 putative metal binding site [ion binding]; other site 698969000268 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698969000269 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 698969000270 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 698969000271 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 698969000272 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698969000273 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698969000274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 698969000275 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698969000276 MarR family; Region: MarR; pfam01047 698969000277 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 698969000278 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698969000279 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698969000280 hypothetical protein; Provisional; Region: PRK10621 698969000281 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698969000282 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 698969000283 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698969000284 ATP binding site [chemical binding]; other site 698969000285 putative Mg++ binding site [ion binding]; other site 698969000286 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698969000287 nucleotide binding region [chemical binding]; other site 698969000288 Helicase associated domain (HA2); Region: HA2; pfam04408 698969000289 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 698969000290 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 698969000291 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698969000292 putative CoA binding site [chemical binding]; other site 698969000293 putative trimer interface [polypeptide binding]; other site 698969000294 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698969000295 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 698969000296 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698969000297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698969000298 NAD(P) binding site [chemical binding]; other site 698969000299 active site 698969000300 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 698969000301 Helix-turn-helix domain; Region: HTH_28; pfam13518 698969000302 Integrase core domain; Region: rve_2; pfam13333 698969000303 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 698969000304 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698969000305 RNA binding surface [nucleotide binding]; other site 698969000306 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698969000307 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698969000308 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698969000309 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 698969000310 active site 698969000311 DNA binding site [nucleotide binding] 698969000312 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 698969000313 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 698969000314 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 698969000315 active site 698969000316 Zn binding site [ion binding]; other site 698969000317 Protease prsW family; Region: PrsW-protease; pfam13367 698969000318 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698969000319 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 698969000320 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 698969000321 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 698969000322 short chain dehydrogenase; Provisional; Region: PRK07904 698969000323 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698969000324 NAD(P) binding site [chemical binding]; other site 698969000325 active site 698969000326 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698969000327 FAD binding domain; Region: FAD_binding_4; pfam01565 698969000328 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 698969000329 Predicted membrane protein [Function unknown]; Region: COG2246 698969000330 GtrA-like protein; Region: GtrA; pfam04138 698969000331 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698969000332 putative active site [active] 698969000333 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698969000334 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698969000335 active site 698969000336 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698969000337 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698969000338 intersubunit interface [polypeptide binding]; other site 698969000339 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698969000340 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698969000341 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698969000342 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698969000343 ABC-ATPase subunit interface; other site 698969000344 dimer interface [polypeptide binding]; other site 698969000345 putative PBP binding regions; other site 698969000346 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698969000347 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698969000348 ABC-ATPase subunit interface; other site 698969000349 dimer interface [polypeptide binding]; other site 698969000350 putative PBP binding regions; other site 698969000351 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698969000352 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698969000353 intersubunit interface [polypeptide binding]; other site 698969000354 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 698969000355 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 698969000356 Walker A/P-loop; other site 698969000357 ATP binding site [chemical binding]; other site 698969000358 Q-loop/lid; other site 698969000359 ABC transporter signature motif; other site 698969000360 Walker B; other site 698969000361 D-loop; other site 698969000362 H-loop/switch region; other site 698969000363 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 698969000364 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698969000365 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698969000366 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698969000367 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698969000368 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 698969000369 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 698969000370 NAD(P) binding site [chemical binding]; other site 698969000371 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 698969000372 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698969000373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698969000374 homodimer interface [polypeptide binding]; other site 698969000375 catalytic residue [active] 698969000376 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 698969000377 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 698969000378 transmembrane helices; other site 698969000379 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698969000380 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 698969000381 NodB motif; other site 698969000382 active site 698969000383 catalytic site [active] 698969000384 metal binding site [ion binding]; metal-binding site 698969000385 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698969000386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698969000387 DNA-binding site [nucleotide binding]; DNA binding site 698969000388 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698969000389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698969000390 homodimer interface [polypeptide binding]; other site 698969000391 catalytic residue [active] 698969000392 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 698969000393 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 698969000394 active site 698969000395 multimer interface [polypeptide binding]; other site 698969000396 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 698969000397 predicted active site [active] 698969000398 catalytic triad [active] 698969000399 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698969000400 active site 698969000401 catalytic site [active] 698969000402 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698969000403 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698969000404 active site 698969000405 catalytic site [active] 698969000406 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 698969000407 HTH-like domain; Region: HTH_21; pfam13276 698969000408 Integrase core domain; Region: rve; pfam00665 698969000409 Integrase core domain; Region: rve_3; cl15866 698969000410 Transposase; Region: HTH_Tnp_1; cl17663 698969000411 prephenate dehydrogenase; Validated; Region: PRK06545 698969000412 prephenate dehydrogenase; Validated; Region: PRK08507 698969000413 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 698969000414 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 698969000415 nucleoside/Zn binding site; other site 698969000416 dimer interface [polypeptide binding]; other site 698969000417 catalytic motif [active] 698969000418 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698969000419 active site 698969000420 Int/Topo IB signature motif; other site 698969000421 DNA binding site [nucleotide binding] 698969000422 Helix-turn-helix domain; Region: HTH_17; pfam12728 698969000423 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 698969000424 DNA binding residues [nucleotide binding] 698969000425 PIN domain; Region: PIN_3; pfam13470 698969000426 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 698969000427 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 698969000428 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 698969000429 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 698969000430 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 698969000431 active site 698969000432 HIGH motif; other site 698969000433 nucleotide binding site [chemical binding]; other site 698969000434 active site 698969000435 KMSKS motif; other site 698969000436 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 698969000437 fructuronate transporter; Provisional; Region: PRK10034; cl15264 698969000438 Shikimate kinase; Region: SKI; pfam01202 698969000439 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 698969000440 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 698969000441 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 698969000442 putative NAD(P) binding site [chemical binding]; other site 698969000443 catalytic Zn binding site [ion binding]; other site 698969000444 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 698969000445 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 698969000446 NADP binding site [chemical binding]; other site 698969000447 homodimer interface [polypeptide binding]; other site 698969000448 active site 698969000449 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 698969000450 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698969000451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698969000452 homodimer interface [polypeptide binding]; other site 698969000453 catalytic residue [active] 698969000454 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 698969000455 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 698969000456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698969000457 Walker A motif; other site 698969000458 ATP binding site [chemical binding]; other site 698969000459 Walker B motif; other site 698969000460 arginine finger; other site 698969000461 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 698969000462 hypothetical protein; Validated; Region: PRK00153 698969000463 recombination protein RecR; Reviewed; Region: recR; PRK00076 698969000464 RecR protein; Region: RecR; pfam02132 698969000465 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 698969000466 putative active site [active] 698969000467 putative metal-binding site [ion binding]; other site 698969000468 tetramer interface [polypeptide binding]; other site 698969000469 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698969000470 catalytic triad [active] 698969000471 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 698969000472 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698969000473 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 698969000474 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 698969000475 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698969000476 active site 698969000477 catalytic site [active] 698969000478 substrate binding site [chemical binding]; other site 698969000479 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 698969000480 dimer interface [polypeptide binding]; other site 698969000481 FMN binding site [chemical binding]; other site 698969000482 NADPH bind site [chemical binding]; other site 698969000483 2-isopropylmalate synthase; Validated; Region: PRK03739 698969000484 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 698969000485 active site 698969000486 catalytic residues [active] 698969000487 metal binding site [ion binding]; metal-binding site 698969000488 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 698969000489 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698969000490 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698969000491 DNA binding residues [nucleotide binding] 698969000492 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698969000493 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698969000494 active site 698969000495 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 698969000496 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698969000497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969000498 putative substrate translocation pore; other site 698969000499 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 698969000500 intersubunit interface [polypeptide binding]; other site 698969000501 active site 698969000502 catalytic residue [active] 698969000503 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 698969000504 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 698969000505 active site 698969000506 substrate binding site [chemical binding]; other site 698969000507 metal binding site [ion binding]; metal-binding site 698969000508 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 698969000509 aspartate kinase; Reviewed; Region: PRK06635 698969000510 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 698969000511 putative nucleotide binding site [chemical binding]; other site 698969000512 putative catalytic residues [active] 698969000513 putative Mg ion binding site [ion binding]; other site 698969000514 putative aspartate binding site [chemical binding]; other site 698969000515 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 698969000516 putative allosteric regulatory site; other site 698969000517 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 698969000518 putative allosteric regulatory residue; other site 698969000519 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 698969000520 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698969000521 RNA polymerase sigma factor; Provisional; Region: PRK12535 698969000522 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698969000523 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698969000524 DNA binding residues [nucleotide binding] 698969000525 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 698969000526 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 698969000527 heme binding pocket [chemical binding]; other site 698969000528 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698969000529 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 698969000530 Walker A/P-loop; other site 698969000531 ATP binding site [chemical binding]; other site 698969000532 Q-loop/lid; other site 698969000533 ABC transporter signature motif; other site 698969000534 Walker B; other site 698969000535 D-loop; other site 698969000536 H-loop/switch region; other site 698969000537 TOBE domain; Region: TOBE_2; pfam08402 698969000538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698969000539 dimer interface [polypeptide binding]; other site 698969000540 conserved gate region; other site 698969000541 ABC-ATPase subunit interface; other site 698969000542 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698969000543 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 698969000544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969000545 putative substrate translocation pore; other site 698969000546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969000547 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698969000548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698969000549 active site 698969000550 phosphorylation site [posttranslational modification] 698969000551 intermolecular recognition site; other site 698969000552 dimerization interface [polypeptide binding]; other site 698969000553 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698969000554 DNA binding site [nucleotide binding] 698969000555 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698969000556 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698969000557 dimer interface [polypeptide binding]; other site 698969000558 phosphorylation site [posttranslational modification] 698969000559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698969000560 ATP binding site [chemical binding]; other site 698969000561 Mg2+ binding site [ion binding]; other site 698969000562 G-X-G motif; other site 698969000563 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 698969000564 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 698969000565 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 698969000566 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 698969000567 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698969000568 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 698969000569 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 698969000570 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698969000571 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 698969000572 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698969000573 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698969000574 Predicted membrane protein [Function unknown]; Region: COG1511 698969000575 Predicted membrane protein [Function unknown]; Region: COG1511 698969000576 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698969000577 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698969000578 putative active site [active] 698969000579 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 698969000580 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698969000581 putative active site [active] 698969000582 putative metal binding site [ion binding]; other site 698969000583 Yqey-like protein; Region: YqeY; pfam09424 698969000584 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698969000585 Transglycosylase; Region: Transgly; pfam00912 698969000586 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698969000587 PASTA domain; Region: PASTA; pfam03793 698969000588 Transcription factor WhiB; Region: Whib; pfam02467 698969000589 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 698969000590 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 698969000591 homotrimer interaction site [polypeptide binding]; other site 698969000592 putative active site [active] 698969000593 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698969000594 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698969000595 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698969000596 ligand binding site [chemical binding]; other site 698969000597 flexible hinge region; other site 698969000598 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698969000599 putative switch regulator; other site 698969000600 non-specific DNA interactions [nucleotide binding]; other site 698969000601 DNA binding site [nucleotide binding] 698969000602 sequence specific DNA binding site [nucleotide binding]; other site 698969000603 putative cAMP binding site [chemical binding]; other site 698969000604 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 698969000605 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698969000606 minor groove reading motif; other site 698969000607 helix-hairpin-helix signature motif; other site 698969000608 substrate binding pocket [chemical binding]; other site 698969000609 active site 698969000610 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 698969000611 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698969000612 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698969000613 catalytic residues [active] 698969000614 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 698969000615 putative active site [active] 698969000616 putative CoA binding site [chemical binding]; other site 698969000617 nudix motif; other site 698969000618 metal binding site [ion binding]; metal-binding site 698969000619 Colicin V production protein; Region: Colicin_V; pfam02674 698969000620 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 698969000621 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698969000622 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698969000623 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698969000624 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 698969000625 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698969000626 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698969000627 motif II; other site 698969000628 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 698969000629 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 698969000630 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 698969000631 ATP binding site [chemical binding]; other site 698969000632 Walker A motif; other site 698969000633 hexamer interface [polypeptide binding]; other site 698969000634 Walker B motif; other site 698969000635 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 698969000636 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 698969000637 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 698969000638 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698969000639 ATP binding site [chemical binding]; other site 698969000640 putative Mg++ binding site [ion binding]; other site 698969000641 nucleotide binding region [chemical binding]; other site 698969000642 helicase superfamily c-terminal domain; Region: HELICc; smart00490 698969000643 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 698969000644 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698969000645 DNA-binding site [nucleotide binding]; DNA binding site 698969000646 RNA-binding motif; other site 698969000647 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698969000648 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698969000649 Walker A/P-loop; other site 698969000650 ATP binding site [chemical binding]; other site 698969000651 Q-loop/lid; other site 698969000652 ABC transporter signature motif; other site 698969000653 Walker B; other site 698969000654 D-loop; other site 698969000655 H-loop/switch region; other site 698969000656 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698969000657 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698969000658 Walker A/P-loop; other site 698969000659 ATP binding site [chemical binding]; other site 698969000660 Q-loop/lid; other site 698969000661 ABC transporter signature motif; other site 698969000662 Walker B; other site 698969000663 D-loop; other site 698969000664 H-loop/switch region; other site 698969000665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969000666 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698969000667 putative substrate translocation pore; other site 698969000668 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698969000669 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 698969000670 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698969000671 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 698969000672 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698969000673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698969000674 dimer interface [polypeptide binding]; other site 698969000675 conserved gate region; other site 698969000676 putative PBP binding loops; other site 698969000677 ABC-ATPase subunit interface; other site 698969000678 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698969000679 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698969000680 NAD(P) binding site [chemical binding]; other site 698969000681 active site 698969000682 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 698969000683 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 698969000684 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 698969000685 active site 698969000686 interdomain interaction site; other site 698969000687 putative metal-binding site [ion binding]; other site 698969000688 nucleotide binding site [chemical binding]; other site 698969000689 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 698969000690 domain I; other site 698969000691 DNA binding groove [nucleotide binding] 698969000692 phosphate binding site [ion binding]; other site 698969000693 domain II; other site 698969000694 domain III; other site 698969000695 nucleotide binding site [chemical binding]; other site 698969000696 catalytic site [active] 698969000697 domain IV; other site 698969000698 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 698969000699 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698969000700 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698969000701 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698969000702 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698969000703 active site 698969000704 Predicted membrane protein [Function unknown]; Region: COG1297 698969000705 putative oligopeptide transporter, OPT family; Region: TIGR00733 698969000706 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 698969000707 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698969000708 catalytic site [active] 698969000709 Asp-box motif; other site 698969000710 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698969000711 dimerization interface [polypeptide binding]; other site 698969000712 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698969000713 cyclase homology domain; Region: CHD; cd07302 698969000714 nucleotidyl binding site; other site 698969000715 metal binding site [ion binding]; metal-binding site 698969000716 dimer interface [polypeptide binding]; other site 698969000717 DNA polymerase III subunit delta'; Validated; Region: PRK07940 698969000718 DNA polymerase III subunit delta'; Validated; Region: PRK08485 698969000719 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 698969000720 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698969000721 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 698969000722 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698969000723 DNA binding site [nucleotide binding] 698969000724 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 698969000725 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 698969000726 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698969000727 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698969000728 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698969000729 Fic family protein [Function unknown]; Region: COG3177 698969000730 Fic/DOC family; Region: Fic; pfam02661 698969000731 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698969000732 Trypsin; Region: Trypsin; pfam00089 698969000733 active site 698969000734 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 698969000735 putative DNA binding site [nucleotide binding]; other site 698969000736 putative Zn2+ binding site [ion binding]; other site 698969000737 potential frameshift: common BLAST hit: gi|227832949|ref|YP_002834656.1| transposase 698969000738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698969000739 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698969000740 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698969000741 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 698969000742 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698969000743 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698969000744 active site 698969000745 catalytic site [active] 698969000746 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 698969000747 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 698969000748 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 698969000749 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 698969000750 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 698969000751 Ca binding site [ion binding]; other site 698969000752 active site 698969000753 catalytic site [active] 698969000754 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 698969000755 acyl-CoA synthetase; Validated; Region: PRK07788 698969000756 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698969000757 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698969000758 acyl-activating enzyme (AAE) consensus motif; other site 698969000759 acyl-activating enzyme (AAE) consensus motif; other site 698969000760 AMP binding site [chemical binding]; other site 698969000761 active site 698969000762 CoA binding site [chemical binding]; other site 698969000763 potential frameshift: common BLAST hit: gi|38233440|ref|NP_939207.1| transposase 698969000764 Integrase core domain; Region: rve_2; pfam13333 698969000765 potential frameshift: common BLAST hit: gi|38233854|ref|NP_939621.1| transposase 698969000766 HTH-like domain; Region: HTH_21; pfam13276 698969000767 Integrase core domain; Region: rve; pfam00665 698969000768 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698969000769 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 698969000770 active site 698969000771 catalytic triad [active] 698969000772 oxyanion hole [active] 698969000773 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 698969000774 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 698969000775 substrate binding site; other site 698969000776 tetramer interface; other site 698969000777 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 698969000778 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 698969000779 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 698969000780 NADP binding site [chemical binding]; other site 698969000781 active site 698969000782 putative substrate binding site [chemical binding]; other site 698969000783 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 698969000784 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 698969000785 NAD binding site [chemical binding]; other site 698969000786 substrate binding site [chemical binding]; other site 698969000787 homodimer interface [polypeptide binding]; other site 698969000788 active site 698969000789 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 698969000790 Zn binding site [ion binding]; other site 698969000791 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 698969000792 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698969000793 Putative esterase; Region: Esterase; pfam00756 698969000794 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 698969000795 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 698969000796 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698969000797 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698969000798 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698969000799 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698969000800 non-specific DNA binding site [nucleotide binding]; other site 698969000801 salt bridge; other site 698969000802 sequence-specific DNA binding site [nucleotide binding]; other site 698969000803 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 698969000804 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698969000805 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 698969000806 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 698969000807 putative Iron-sulfur protein interface [polypeptide binding]; other site 698969000808 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 698969000809 proximal heme binding site [chemical binding]; other site 698969000810 distal heme binding site [chemical binding]; other site 698969000811 putative dimer interface [polypeptide binding]; other site 698969000812 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 698969000813 L-aspartate oxidase; Provisional; Region: PRK06175 698969000814 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 698969000815 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 698969000816 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 698969000817 Predicted membrane protein [Function unknown]; Region: COG2733 698969000818 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 698969000819 Class I aldolases; Region: Aldolase_Class_I; cl17187 698969000820 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698969000821 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 698969000822 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698969000823 FeS/SAM binding site; other site 698969000824 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 698969000825 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698969000826 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 698969000827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698969000828 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 698969000829 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 698969000830 FAD binding domain; Region: FAD_binding_4; pfam01565 698969000831 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 698969000832 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 698969000833 pentamer interface [polypeptide binding]; other site 698969000834 dodecaamer interface [polypeptide binding]; other site 698969000835 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698969000836 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698969000837 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698969000838 acyl-activating enzyme (AAE) consensus motif; other site 698969000839 AMP binding site [chemical binding]; other site 698969000840 active site 698969000841 CoA binding site [chemical binding]; other site 698969000842 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698969000843 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698969000844 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698969000845 acyl-activating enzyme (AAE) consensus motif; other site 698969000846 AMP binding site [chemical binding]; other site 698969000847 active site 698969000848 CoA binding site [chemical binding]; other site 698969000849 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 698969000850 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 698969000851 putative ADP-binding pocket [chemical binding]; other site 698969000852 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698969000853 catalytic core [active] 698969000854 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698969000855 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698969000856 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698969000857 dimer interface [polypeptide binding]; other site 698969000858 phosphorylation site [posttranslational modification] 698969000859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698969000860 ATP binding site [chemical binding]; other site 698969000861 Mg2+ binding site [ion binding]; other site 698969000862 G-X-G motif; other site 698969000863 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698969000864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698969000865 active site 698969000866 phosphorylation site [posttranslational modification] 698969000867 intermolecular recognition site; other site 698969000868 dimerization interface [polypeptide binding]; other site 698969000869 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698969000870 DNA binding site [nucleotide binding] 698969000871 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698969000872 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 698969000873 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 698969000874 DNA binding domain, excisionase family; Region: excise; TIGR01764 698969000875 Thioredoxin; Region: Thioredoxin_4; cl17273 698969000876 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698969000877 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698969000878 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 698969000879 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698969000880 motif II; other site 698969000881 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 698969000882 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 698969000883 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 698969000884 tRNA; other site 698969000885 putative tRNA binding site [nucleotide binding]; other site 698969000886 putative NADP binding site [chemical binding]; other site 698969000887 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 698969000888 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 698969000889 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 698969000890 domain interfaces; other site 698969000891 active site 698969000892 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 698969000893 active site 698969000894 homodimer interface [polypeptide binding]; other site 698969000895 SAM binding site [chemical binding]; other site 698969000896 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 698969000897 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 698969000898 active site 698969000899 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 698969000900 dimer interface [polypeptide binding]; other site 698969000901 active site 698969000902 Schiff base residues; other site 698969000903 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 698969000904 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698969000905 Predicted membrane protein [Function unknown]; Region: COG2311 698969000906 Protein of unknown function (DUF418); Region: DUF418; pfam04235 698969000907 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 698969000908 substrate binding site [chemical binding]; other site 698969000909 active site 698969000910 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 698969000911 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 698969000912 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698969000913 inhibitor-cofactor binding pocket; inhibition site 698969000914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698969000915 catalytic residue [active] 698969000916 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698969000917 catalytic core [active] 698969000918 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698969000919 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698969000920 catalytic residues [active] 698969000921 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698969000922 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698969000923 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 698969000924 ResB-like family; Region: ResB; pfam05140 698969000925 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 698969000926 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698969000927 dimerization interface [polypeptide binding]; other site 698969000928 putative DNA binding site [nucleotide binding]; other site 698969000929 putative Zn2+ binding site [ion binding]; other site 698969000930 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 698969000931 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 698969000932 UbiA prenyltransferase family; Region: UbiA; pfam01040 698969000933 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698969000934 active site 698969000935 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698969000936 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 698969000937 acyl-activating enzyme (AAE) consensus motif; other site 698969000938 AMP binding site [chemical binding]; other site 698969000939 active site 698969000940 CoA binding site [chemical binding]; other site 698969000941 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 698969000942 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698969000943 substrate binding site [chemical binding]; other site 698969000944 oxyanion hole (OAH) forming residues; other site 698969000945 trimer interface [polypeptide binding]; other site 698969000946 O-succinylbenzoate synthase; Provisional; Region: PRK02901 698969000947 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 698969000948 active site 698969000949 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 698969000950 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 698969000951 dimer interface [polypeptide binding]; other site 698969000952 tetramer interface [polypeptide binding]; other site 698969000953 PYR/PP interface [polypeptide binding]; other site 698969000954 TPP binding site [chemical binding]; other site 698969000955 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 698969000956 TPP-binding site; other site 698969000957 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698969000958 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 698969000959 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 698969000960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698969000961 S-adenosylmethionine binding site [chemical binding]; other site 698969000962 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 698969000963 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 698969000964 NAD binding site [chemical binding]; other site 698969000965 dimer interface [polypeptide binding]; other site 698969000966 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698969000967 substrate binding site [chemical binding]; other site 698969000968 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 698969000969 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698969000970 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698969000971 substrate binding pocket [chemical binding]; other site 698969000972 chain length determination region; other site 698969000973 substrate-Mg2+ binding site; other site 698969000974 catalytic residues [active] 698969000975 aspartate-rich region 1; other site 698969000976 active site lid residues [active] 698969000977 aspartate-rich region 2; other site 698969000978 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 698969000979 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 698969000980 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 698969000981 putative homodimer interface [polypeptide binding]; other site 698969000982 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 698969000983 heterodimer interface [polypeptide binding]; other site 698969000984 homodimer interface [polypeptide binding]; other site 698969000985 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 698969000986 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 698969000987 23S rRNA interface [nucleotide binding]; other site 698969000988 L7/L12 interface [polypeptide binding]; other site 698969000989 putative thiostrepton binding site; other site 698969000990 L25 interface [polypeptide binding]; other site 698969000991 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 698969000992 mRNA/rRNA interface [nucleotide binding]; other site 698969000993 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 698969000994 23S rRNA interface [nucleotide binding]; other site 698969000995 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 698969000996 50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157 698969000997 L11 interface [polypeptide binding]; other site 698969000998 putative EF-Tu interaction site [polypeptide binding]; other site 698969000999 putative EF-G interaction site [polypeptide binding]; other site 698969001000 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 698969001001 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698969001002 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698969001003 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698969001004 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698969001005 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698969001006 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 698969001007 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698969001008 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698969001009 ABC-ATPase subunit interface; other site 698969001010 dimer interface [polypeptide binding]; other site 698969001011 putative PBP binding regions; other site 698969001012 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698969001013 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698969001014 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698969001015 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698969001016 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 698969001017 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 698969001018 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 698969001019 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 698969001020 RPB1 interaction site [polypeptide binding]; other site 698969001021 RPB10 interaction site [polypeptide binding]; other site 698969001022 RPB11 interaction site [polypeptide binding]; other site 698969001023 RPB3 interaction site [polypeptide binding]; other site 698969001024 RPB12 interaction site [polypeptide binding]; other site 698969001025 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 698969001026 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 698969001027 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 698969001028 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 698969001029 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 698969001030 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698969001031 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 698969001032 G-loop; other site 698969001033 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698969001034 DNA binding site [nucleotide binding] 698969001035 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 698969001036 Transposase; Region: DDE_Tnp_ISL3; pfam01610 698969001037 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698969001038 Histidine kinase; Region: HisKA_3; pfam07730 698969001039 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698969001040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698969001041 active site 698969001042 phosphorylation site [posttranslational modification] 698969001043 intermolecular recognition site; other site 698969001044 dimerization interface [polypeptide binding]; other site 698969001045 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698969001046 DNA binding residues [nucleotide binding] 698969001047 dimerization interface [polypeptide binding]; other site 698969001048 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698969001049 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698969001050 Walker A/P-loop; other site 698969001051 ATP binding site [chemical binding]; other site 698969001052 Q-loop/lid; other site 698969001053 ABC transporter signature motif; other site 698969001054 Walker B; other site 698969001055 D-loop; other site 698969001056 H-loop/switch region; other site 698969001057 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 698969001058 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698969001059 TIGR03943 family protein; Region: TIGR03943 698969001060 Predicted permeases [General function prediction only]; Region: COG0701 698969001061 Radical SAM superfamily; Region: Radical_SAM; pfam04055 698969001062 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698969001063 FeS/SAM binding site; other site 698969001064 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 698969001065 Class III ribonucleotide reductase; Region: RNR_III; cd01675 698969001066 effector binding site; other site 698969001067 active site 698969001068 Zn binding site [ion binding]; other site 698969001069 glycine loop; other site 698969001070 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 698969001071 S17 interaction site [polypeptide binding]; other site 698969001072 S8 interaction site; other site 698969001073 16S rRNA interaction site [nucleotide binding]; other site 698969001074 streptomycin interaction site [chemical binding]; other site 698969001075 23S rRNA interaction site [nucleotide binding]; other site 698969001076 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 698969001077 30S ribosomal protein S7; Validated; Region: PRK05302 698969001078 elongation factor G; Reviewed; Region: PRK00007 698969001079 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 698969001080 G1 box; other site 698969001081 putative GEF interaction site [polypeptide binding]; other site 698969001082 GTP/Mg2+ binding site [chemical binding]; other site 698969001083 Switch I region; other site 698969001084 G2 box; other site 698969001085 G3 box; other site 698969001086 Switch II region; other site 698969001087 G4 box; other site 698969001088 G5 box; other site 698969001089 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 698969001090 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 698969001091 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 698969001092 elongation factor Tu; Reviewed; Region: PRK00049 698969001093 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 698969001094 G1 box; other site 698969001095 GEF interaction site [polypeptide binding]; other site 698969001096 GTP/Mg2+ binding site [chemical binding]; other site 698969001097 Switch I region; other site 698969001098 G2 box; other site 698969001099 G3 box; other site 698969001100 Switch II region; other site 698969001101 G4 box; other site 698969001102 G5 box; other site 698969001103 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 698969001104 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 698969001105 Antibiotic Binding Site [chemical binding]; other site 698969001106 Predicted membrane protein [Function unknown]; Region: COG2323 698969001107 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 698969001108 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 698969001109 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 698969001110 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 698969001111 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 698969001112 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 698969001113 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 698969001114 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 698969001115 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 698969001116 putative translocon binding site; other site 698969001117 protein-rRNA interface [nucleotide binding]; other site 698969001118 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 698969001119 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 698969001120 G-X-X-G motif; other site 698969001121 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 698969001122 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 698969001123 23S rRNA interface [nucleotide binding]; other site 698969001124 5S rRNA interface [nucleotide binding]; other site 698969001125 putative antibiotic binding site [chemical binding]; other site 698969001126 L25 interface [polypeptide binding]; other site 698969001127 L27 interface [polypeptide binding]; other site 698969001128 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 698969001129 putative translocon interaction site; other site 698969001130 23S rRNA interface [nucleotide binding]; other site 698969001131 signal recognition particle (SRP54) interaction site; other site 698969001132 L23 interface [polypeptide binding]; other site 698969001133 trigger factor interaction site; other site 698969001134 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 698969001135 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698969001136 HlyD family secretion protein; Region: HlyD_3; pfam13437 698969001137 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698969001138 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698969001139 Walker A/P-loop; other site 698969001140 ATP binding site [chemical binding]; other site 698969001141 Q-loop/lid; other site 698969001142 ABC transporter signature motif; other site 698969001143 Walker B; other site 698969001144 D-loop; other site 698969001145 H-loop/switch region; other site 698969001146 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698969001147 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698969001148 FtsX-like permease family; Region: FtsX; pfam02687 698969001149 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 698969001150 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 698969001151 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 698969001152 RNA binding site [nucleotide binding]; other site 698969001153 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 698969001154 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 698969001155 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 698969001156 putative transposase OrfB; Reviewed; Region: PHA02517 698969001157 HTH-like domain; Region: HTH_21; pfam13276 698969001158 Integrase core domain; Region: rve; pfam00665 698969001159 Integrase core domain; Region: rve_2; pfam13333 698969001160 potential frameshift: common BLAST hit: gi|38234641|ref|NP_940408.1| insertion element 698969001161 Homeodomain-like domain; Region: HTH_23; cl17451 698969001162 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 698969001163 serine transporter; Region: stp; TIGR00814 698969001164 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698969001165 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698969001166 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698969001167 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698969001168 active site 698969001169 homotetramer interface [polypeptide binding]; other site 698969001170 homodimer interface [polypeptide binding]; other site 698969001171 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 698969001172 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698969001173 ATP binding site [chemical binding]; other site 698969001174 substrate interface [chemical binding]; other site 698969001175 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698969001176 active site residue [active] 698969001177 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698969001178 MPT binding site; other site 698969001179 trimer interface [polypeptide binding]; other site 698969001180 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 698969001181 MoaE homodimer interface [polypeptide binding]; other site 698969001182 MoaD interaction [polypeptide binding]; other site 698969001183 active site residues [active] 698969001184 Predicted transcriptional regulator [Transcription]; Region: COG2345 698969001185 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 698969001186 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698969001187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698969001188 dimer interface [polypeptide binding]; other site 698969001189 conserved gate region; other site 698969001190 putative PBP binding loops; other site 698969001191 ABC-ATPase subunit interface; other site 698969001192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969001193 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 698969001194 Walker A/P-loop; other site 698969001195 ATP binding site [chemical binding]; other site 698969001196 Q-loop/lid; other site 698969001197 ABC transporter signature motif; other site 698969001198 Walker B; other site 698969001199 D-loop; other site 698969001200 H-loop/switch region; other site 698969001201 TOBE domain; Region: TOBE; cl01440 698969001202 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 698969001203 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698969001204 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 698969001205 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 698969001206 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 698969001207 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 698969001208 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 698969001209 [4Fe-4S] binding site [ion binding]; other site 698969001210 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698969001211 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698969001212 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698969001213 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 698969001214 molybdopterin cofactor binding site; other site 698969001215 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 698969001216 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 698969001217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969001218 putative substrate translocation pore; other site 698969001219 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698969001220 MPT binding site; other site 698969001221 trimer interface [polypeptide binding]; other site 698969001222 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 698969001223 GTP binding site; other site 698969001224 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 698969001225 trimer interface [polypeptide binding]; other site 698969001226 dimer interface [polypeptide binding]; other site 698969001227 putative active site [active] 698969001228 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698969001229 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698969001230 dimer interface [polypeptide binding]; other site 698969001231 putative functional site; other site 698969001232 putative MPT binding site; other site 698969001233 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 698969001234 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698969001235 FeS/SAM binding site; other site 698969001236 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 698969001237 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698969001238 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698969001239 inhibitor site; inhibition site 698969001240 active site 698969001241 dimer interface [polypeptide binding]; other site 698969001242 catalytic residue [active] 698969001243 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698969001244 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698969001245 Walker A/P-loop; other site 698969001246 ATP binding site [chemical binding]; other site 698969001247 Q-loop/lid; other site 698969001248 ABC transporter signature motif; other site 698969001249 Walker B; other site 698969001250 D-loop; other site 698969001251 H-loop/switch region; other site 698969001252 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698969001253 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698969001254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698969001255 dimer interface [polypeptide binding]; other site 698969001256 conserved gate region; other site 698969001257 putative PBP binding loops; other site 698969001258 ABC-ATPase subunit interface; other site 698969001259 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698969001260 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698969001261 Walker A/P-loop; other site 698969001262 ATP binding site [chemical binding]; other site 698969001263 Q-loop/lid; other site 698969001264 ABC transporter signature motif; other site 698969001265 Walker B; other site 698969001266 D-loop; other site 698969001267 H-loop/switch region; other site 698969001268 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698969001269 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698969001270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698969001271 dimer interface [polypeptide binding]; other site 698969001272 conserved gate region; other site 698969001273 putative PBP binding loops; other site 698969001274 ABC-ATPase subunit interface; other site 698969001275 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 698969001276 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698969001277 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698969001278 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698969001279 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698969001280 DNA-binding site [nucleotide binding]; DNA binding site 698969001281 FCD domain; Region: FCD; pfam07729 698969001282 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698969001283 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698969001284 nucleotide binding site [chemical binding]; other site 698969001285 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 698969001286 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 698969001287 putative active site cavity [active] 698969001288 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 698969001289 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 698969001290 active site 698969001291 dimer interface [polypeptide binding]; other site 698969001292 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698969001293 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 698969001294 active site 698969001295 trimer interface [polypeptide binding]; other site 698969001296 allosteric site; other site 698969001297 active site lid [active] 698969001298 hexamer (dimer of trimers) interface [polypeptide binding]; other site 698969001299 Htaa; Region: HtaA; pfam04213 698969001300 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 698969001301 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 698969001302 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698969001303 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698969001304 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 698969001305 5S rRNA interface [nucleotide binding]; other site 698969001306 L27 interface [polypeptide binding]; other site 698969001307 23S rRNA interface [nucleotide binding]; other site 698969001308 L5 interface [polypeptide binding]; other site 698969001309 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 698969001310 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 698969001311 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 698969001312 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 698969001313 23S rRNA binding site [nucleotide binding]; other site 698969001314 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 698969001315 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 698969001316 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 698969001317 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 698969001318 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698969001319 active site 698969001320 catalytic site [active] 698969001321 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698969001322 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698969001323 active site 698969001324 catalytic site [active] 698969001325 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 698969001326 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698969001327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698969001328 dimer interface [polypeptide binding]; other site 698969001329 conserved gate region; other site 698969001330 putative PBP binding loops; other site 698969001331 ABC-ATPase subunit interface; other site 698969001332 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698969001333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698969001334 dimer interface [polypeptide binding]; other site 698969001335 conserved gate region; other site 698969001336 putative PBP binding loops; other site 698969001337 ABC-ATPase subunit interface; other site 698969001338 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 698969001339 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698969001340 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698969001341 Walker A/P-loop; other site 698969001342 ATP binding site [chemical binding]; other site 698969001343 Q-loop/lid; other site 698969001344 ABC transporter signature motif; other site 698969001345 Walker B; other site 698969001346 D-loop; other site 698969001347 H-loop/switch region; other site 698969001348 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 698969001349 SecY translocase; Region: SecY; pfam00344 698969001350 adenylate kinase; Reviewed; Region: adk; PRK00279 698969001351 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 698969001352 AMP-binding site [chemical binding]; other site 698969001353 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 698969001354 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698969001355 active site 698969001356 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698969001357 catalytic site [active] 698969001358 BNR repeat-like domain; Region: BNR_2; pfam13088 698969001359 Asp-box motif; other site 698969001360 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698969001361 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 698969001362 rRNA binding site [nucleotide binding]; other site 698969001363 predicted 30S ribosome binding site; other site 698969001364 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 698969001365 30S ribosomal protein S13; Region: bact_S13; TIGR03631 698969001366 30S ribosomal protein S11; Validated; Region: PRK05309 698969001367 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 698969001368 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 698969001369 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698969001370 RNA binding surface [nucleotide binding]; other site 698969001371 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 698969001372 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 698969001373 alphaNTD - beta interaction site [polypeptide binding]; other site 698969001374 alphaNTD homodimer interface [polypeptide binding]; other site 698969001375 alphaNTD - beta' interaction site [polypeptide binding]; other site 698969001376 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 698969001377 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 698969001378 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 698969001379 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 698969001380 dimerization interface 3.5A [polypeptide binding]; other site 698969001381 active site 698969001382 Protein of unknown function (DUF690); Region: DUF690; cl04939 698969001383 TIGR02611 family protein; Region: TIGR02611 698969001384 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 698969001385 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 698969001386 active site 698969001387 catalytic residues [active] 698969001388 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 698969001389 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 698969001390 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698969001391 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 698969001392 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698969001393 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698969001394 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 698969001395 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 698969001396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 698969001397 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 698969001398 23S rRNA interface [nucleotide binding]; other site 698969001399 L3 interface [polypeptide binding]; other site 698969001400 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 698969001401 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 698969001402 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 698969001403 active site 698969001404 substrate binding site [chemical binding]; other site 698969001405 metal binding site [ion binding]; metal-binding site 698969001406 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 698969001407 alanine racemase; Reviewed; Region: alr; PRK00053 698969001408 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 698969001409 active site 698969001410 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698969001411 dimer interface [polypeptide binding]; other site 698969001412 substrate binding site [chemical binding]; other site 698969001413 catalytic residues [active] 698969001414 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 698969001415 Predicted permease [General function prediction only]; Region: COG2985 698969001416 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698969001417 TrkA-C domain; Region: TrkA_C; pfam02080 698969001418 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698969001419 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698969001420 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 698969001421 Glycoprotease family; Region: Peptidase_M22; pfam00814 698969001422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698969001423 Coenzyme A binding pocket [chemical binding]; other site 698969001424 UGMP family protein; Validated; Region: PRK09604 698969001425 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 698969001426 oligomerisation interface [polypeptide binding]; other site 698969001427 mobile loop; other site 698969001428 roof hairpin; other site 698969001429 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698969001430 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698969001431 ring oligomerisation interface [polypeptide binding]; other site 698969001432 ATP/Mg binding site [chemical binding]; other site 698969001433 stacking interactions; other site 698969001434 hinge regions; other site 698969001435 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 698969001436 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698969001437 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698969001438 DNA binding residues [nucleotide binding] 698969001439 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 698969001440 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698969001441 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 698969001442 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 698969001443 active site 698969001444 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 698969001445 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698969001446 phosphate binding site [ion binding]; other site 698969001447 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698969001448 siderophore binding site; other site 698969001449 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698969001450 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698969001451 dimer interface [polypeptide binding]; other site 698969001452 putative PBP binding regions; other site 698969001453 ABC-ATPase subunit interface; other site 698969001454 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698969001455 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698969001456 ABC-ATPase subunit interface; other site 698969001457 dimer interface [polypeptide binding]; other site 698969001458 putative PBP binding regions; other site 698969001459 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698969001460 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698969001461 Walker A/P-loop; other site 698969001462 ATP binding site [chemical binding]; other site 698969001463 Q-loop/lid; other site 698969001464 ABC transporter signature motif; other site 698969001465 Walker B; other site 698969001466 D-loop; other site 698969001467 H-loop/switch region; other site 698969001468 IucA / IucC family; Region: IucA_IucC; pfam04183 698969001469 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698969001470 IucA / IucC family; Region: IucA_IucC; pfam04183 698969001471 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698969001472 H+ Antiporter protein; Region: 2A0121; TIGR00900 698969001473 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 698969001474 EamA-like transporter family; Region: EamA; pfam00892 698969001475 GMP synthase; Reviewed; Region: guaA; PRK00074 698969001476 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 698969001477 AMP/PPi binding site [chemical binding]; other site 698969001478 candidate oxyanion hole; other site 698969001479 catalytic triad [active] 698969001480 potential glutamine specificity residues [chemical binding]; other site 698969001481 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 698969001482 ATP Binding subdomain [chemical binding]; other site 698969001483 Ligand Binding sites [chemical binding]; other site 698969001484 Dimerization subdomain; other site 698969001485 PspC domain; Region: PspC; pfam04024 698969001486 PspC domain; Region: PspC; pfam04024 698969001487 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698969001488 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698969001489 ATP binding site [chemical binding]; other site 698969001490 Mg2+ binding site [ion binding]; other site 698969001491 G-X-G motif; other site 698969001492 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698969001493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698969001494 active site 698969001495 phosphorylation site [posttranslational modification] 698969001496 intermolecular recognition site; other site 698969001497 dimerization interface [polypeptide binding]; other site 698969001498 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698969001499 DNA binding residues [nucleotide binding] 698969001500 dimerization interface [polypeptide binding]; other site 698969001501 potential frameshift: common BLAST hit: gi|38233680|ref|NP_939447.1| iron transport system exported solute-binding component 698969001502 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698969001503 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698969001504 DNA Polymerase Y-family; Region: PolY_like; cd03468 698969001505 active site 698969001506 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 698969001507 DNA binding site [nucleotide binding] 698969001508 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 698969001509 putative dimer interface [polypeptide binding]; other site 698969001510 putative [2Fe-2S] cluster binding site [ion binding]; other site 698969001511 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698969001512 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698969001513 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698969001514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698969001515 dimer interface [polypeptide binding]; other site 698969001516 conserved gate region; other site 698969001517 ABC-ATPase subunit interface; other site 698969001518 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 698969001519 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 698969001520 Walker A/P-loop; other site 698969001521 ATP binding site [chemical binding]; other site 698969001522 Q-loop/lid; other site 698969001523 ABC transporter signature motif; other site 698969001524 Walker B; other site 698969001525 D-loop; other site 698969001526 H-loop/switch region; other site 698969001527 NIL domain; Region: NIL; cl09633 698969001528 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698969001529 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 698969001530 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698969001531 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 698969001532 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 698969001533 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 698969001534 active site 698969001535 PHP Thumb interface [polypeptide binding]; other site 698969001536 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698969001537 generic binding surface II; other site 698969001538 generic binding surface I; other site 698969001539 Uncharacterized conserved protein [Function unknown]; Region: COG3402 698969001540 Predicted membrane protein [Function unknown]; Region: COG3428 698969001541 Bacterial PH domain; Region: DUF304; pfam03703 698969001542 Bacterial PH domain; Region: DUF304; pfam03703 698969001543 Bacterial PH domain; Region: DUF304; pfam03703 698969001544 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698969001545 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698969001546 intersubunit interface [polypeptide binding]; other site 698969001547 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698969001548 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698969001549 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698969001550 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698969001551 dimer interface [polypeptide binding]; other site 698969001552 putative PBP binding regions; other site 698969001553 ABC-ATPase subunit interface; other site 698969001554 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698969001555 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698969001556 ABC-ATPase subunit interface; other site 698969001557 dimer interface [polypeptide binding]; other site 698969001558 putative PBP binding regions; other site 698969001559 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698969001560 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698969001561 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698969001562 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 698969001563 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 698969001564 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 698969001565 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 698969001566 homodimer interface [polypeptide binding]; other site 698969001567 NADP binding site [chemical binding]; other site 698969001568 substrate binding site [chemical binding]; other site 698969001569 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 698969001570 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698969001571 active site 698969001572 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 698969001573 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 698969001574 Htaa; Region: HtaA; pfam04213 698969001575 Htaa; Region: HtaA; pfam04213 698969001576 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698969001577 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698969001578 intersubunit interface [polypeptide binding]; other site 698969001579 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698969001580 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698969001581 ABC-ATPase subunit interface; other site 698969001582 dimer interface [polypeptide binding]; other site 698969001583 putative PBP binding regions; other site 698969001584 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 698969001585 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698969001586 Walker A/P-loop; other site 698969001587 ATP binding site [chemical binding]; other site 698969001588 Q-loop/lid; other site 698969001589 ABC transporter signature motif; other site 698969001590 Walker B; other site 698969001591 D-loop; other site 698969001592 H-loop/switch region; other site 698969001593 Htaa; Region: HtaA; pfam04213 698969001594 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 698969001595 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698969001596 homodimer interface [polypeptide binding]; other site 698969001597 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698969001598 substrate-cofactor binding pocket; other site 698969001599 catalytic residue [active] 698969001600 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 698969001601 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 698969001602 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698969001603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969001604 putative substrate translocation pore; other site 698969001605 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698969001606 putative catalytic site [active] 698969001607 putative metal binding site [ion binding]; other site 698969001608 putative phosphate binding site [ion binding]; other site 698969001609 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 698969001610 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 698969001611 active site 698969001612 HIGH motif; other site 698969001613 dimer interface [polypeptide binding]; other site 698969001614 KMSKS motif; other site 698969001615 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 698969001616 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698969001617 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698969001618 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698969001619 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698969001620 NlpC/P60 family; Region: NLPC_P60; pfam00877 698969001621 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698969001622 active site 698969001623 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698969001624 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698969001625 non-specific DNA binding site [nucleotide binding]; other site 698969001626 salt bridge; other site 698969001627 sequence-specific DNA binding site [nucleotide binding]; other site 698969001628 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698969001629 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 698969001630 metal binding site [ion binding]; metal-binding site 698969001631 putative dimer interface [polypeptide binding]; other site 698969001632 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 698969001633 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698969001634 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698969001635 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698969001636 pyruvate carboxylase; Reviewed; Region: PRK12999 698969001637 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698969001638 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698969001639 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698969001640 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698969001641 active site 698969001642 catalytic residues [active] 698969001643 metal binding site [ion binding]; metal-binding site 698969001644 homodimer binding site [polypeptide binding]; other site 698969001645 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698969001646 carboxyltransferase (CT) interaction site; other site 698969001647 biotinylation site [posttranslational modification]; other site 698969001648 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 698969001649 ADP-ribose binding site [chemical binding]; other site 698969001650 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 698969001651 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698969001652 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 698969001653 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698969001654 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698969001655 carboxyltransferase (CT) interaction site; other site 698969001656 biotinylation site [posttranslational modification]; other site 698969001657 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698969001658 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698969001659 active site residue [active] 698969001660 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698969001661 active site residue [active] 698969001662 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698969001663 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 698969001664 active site 698969001665 dimer interface [polypeptide binding]; other site 698969001666 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 698969001667 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698969001668 substrate binding site [chemical binding]; other site 698969001669 dimer interface [polypeptide binding]; other site 698969001670 ATP binding site [chemical binding]; other site 698969001671 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698969001672 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698969001673 DNA binding site [nucleotide binding] 698969001674 domain linker motif; other site 698969001675 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 698969001676 dimerization interface [polypeptide binding]; other site 698969001677 putative ligand binding site [chemical binding]; other site 698969001678 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 698969001679 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698969001680 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698969001681 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698969001682 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698969001683 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698969001684 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698969001685 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 698969001686 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 698969001687 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 698969001688 ATP-grasp domain; Region: ATP-grasp; pfam02222 698969001689 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 698969001690 Uncharacterized conserved protein [Function unknown]; Region: COG1434 698969001691 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698969001692 putative active site [active] 698969001693 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 698969001694 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 698969001695 HupF/HypC family; Region: HupF_HypC; pfam01455 698969001696 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 698969001697 dimerization interface [polypeptide binding]; other site 698969001698 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 698969001699 ATP binding site [chemical binding]; other site 698969001700 Acylphosphatase; Region: Acylphosphatase; pfam00708 698969001701 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 698969001702 HypF finger; Region: zf-HYPF; pfam07503 698969001703 HypF finger; Region: zf-HYPF; pfam07503 698969001704 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 698969001705 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 698969001706 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698969001707 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 698969001708 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 698969001709 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 698969001710 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 698969001711 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 698969001712 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 698969001713 putative substrate-binding site; other site 698969001714 nickel binding site [ion binding]; other site 698969001715 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 698969001716 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 698969001717 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 698969001718 HupF/HypC family; Region: HupF_HypC; cl00394 698969001719 TIGR03089 family protein; Region: TIGR03089 698969001720 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698969001721 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698969001722 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698969001723 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698969001724 active site 698969001725 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698969001726 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 698969001727 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 698969001728 active site 698969001729 Substrate binding site; other site 698969001730 Mg++ binding site; other site 698969001731 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698969001732 putative trimer interface [polypeptide binding]; other site 698969001733 putative CoA binding site [chemical binding]; other site 698969001734 putative transposase OrfB; Reviewed; Region: PHA02517 698969001735 HTH-like domain; Region: HTH_21; pfam13276 698969001736 Integrase core domain; Region: rve; pfam00665 698969001737 Integrase core domain; Region: rve_2; pfam13333 698969001738 potential frameshift: common BLAST hit: gi|38234641|ref|NP_940408.1| insertion element 698969001739 Homeodomain-like domain; Region: HTH_23; cl17451 698969001740 Transcription factor WhiB; Region: Whib; pfam02467 698969001741 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 698969001742 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 698969001743 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 698969001744 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 698969001745 active site 698969001746 substrate binding site [chemical binding]; other site 698969001747 metal binding site [ion binding]; metal-binding site 698969001748 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 698969001749 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698969001750 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698969001751 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 698969001752 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 698969001753 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 698969001754 homotetramer interface [polypeptide binding]; other site 698969001755 ligand binding site [chemical binding]; other site 698969001756 catalytic site [active] 698969001757 NAD binding site [chemical binding]; other site 698969001758 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 698969001759 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 698969001760 TMP-binding site; other site 698969001761 ATP-binding site [chemical binding]; other site 698969001762 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698969001763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698969001764 active site 698969001765 phosphorylation site [posttranslational modification] 698969001766 intermolecular recognition site; other site 698969001767 dimerization interface [polypeptide binding]; other site 698969001768 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698969001769 DNA binding site [nucleotide binding] 698969001770 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698969001771 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698969001772 dimerization interface [polypeptide binding]; other site 698969001773 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698969001774 dimer interface [polypeptide binding]; other site 698969001775 phosphorylation site [posttranslational modification] 698969001776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698969001777 ATP binding site [chemical binding]; other site 698969001778 Mg2+ binding site [ion binding]; other site 698969001779 G-X-G motif; other site 698969001780 lipoprotein LpqB; Provisional; Region: PRK13616 698969001781 Sporulation and spore germination; Region: Germane; pfam10646 698969001782 comF family protein; Region: comF; TIGR00201 698969001783 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698969001784 active site 698969001785 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 698969001786 30S subunit binding site; other site 698969001787 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 698969001788 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698969001789 ATP binding site [chemical binding]; other site 698969001790 putative Mg++ binding site [ion binding]; other site 698969001791 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 698969001792 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 698969001793 nucleotide binding region [chemical binding]; other site 698969001794 ATP-binding site [chemical binding]; other site 698969001795 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 698969001796 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 698969001797 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698969001798 FAD binding pocket [chemical binding]; other site 698969001799 FAD binding motif [chemical binding]; other site 698969001800 phosphate binding motif [ion binding]; other site 698969001801 beta-alpha-beta structure motif; other site 698969001802 NAD binding pocket [chemical binding]; other site 698969001803 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698969001804 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 698969001805 catalytic loop [active] 698969001806 iron binding site [ion binding]; other site 698969001807 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 698969001808 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 698969001809 putative di-iron ligands [ion binding]; other site 698969001810 Predicted GTPases [General function prediction only]; Region: COG1162 698969001811 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 698969001812 GTPase/Zn-binding domain interface [polypeptide binding]; other site 698969001813 GTP/Mg2+ binding site [chemical binding]; other site 698969001814 G4 box; other site 698969001815 G5 box; other site 698969001816 G1 box; other site 698969001817 Switch I region; other site 698969001818 G2 box; other site 698969001819 G3 box; other site 698969001820 Switch II region; other site 698969001821 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 698969001822 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 698969001823 hinge; other site 698969001824 active site 698969001825 Uncharacterized conserved protein [Function unknown]; Region: COG2135 698969001826 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 698969001827 putative deacylase active site [active] 698969001828 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 698969001829 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698969001830 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698969001831 DNA binding residues [nucleotide binding] 698969001832 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 698969001833 Transcription factor WhiB; Region: Whib; pfam02467 698969001834 PQQ-like domain; Region: PQQ_2; pfam13360 698969001835 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698969001836 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698969001837 ATP binding site [chemical binding]; other site 698969001838 putative Mg++ binding site [ion binding]; other site 698969001839 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698969001840 nucleotide binding region [chemical binding]; other site 698969001841 ATP-binding site [chemical binding]; other site 698969001842 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 698969001843 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 698969001844 TIGR02569 family protein; Region: TIGR02569_actnb 698969001845 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698969001846 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698969001847 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698969001848 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698969001849 Part of AAA domain; Region: AAA_19; pfam13245 698969001850 Family description; Region: UvrD_C_2; pfam13538 698969001851 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698969001852 Ion channel; Region: Ion_trans_2; pfam07885 698969001853 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 698969001854 TrkA-N domain; Region: TrkA_N; pfam02254 698969001855 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 698969001856 putative NADH binding site [chemical binding]; other site 698969001857 putative active site [active] 698969001858 nudix motif; other site 698969001859 putative metal binding site [ion binding]; other site 698969001860 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 698969001861 Part of AAA domain; Region: AAA_19; pfam13245 698969001862 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698969001863 Family description; Region: UvrD_C_2; pfam13538 698969001864 HRDC domain; Region: HRDC; pfam00570 698969001865 Protein of unknown function DUF45; Region: DUF45; cl00636 698969001866 putative hydrolase; Region: TIGR03624 698969001867 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 698969001868 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698969001869 hypothetical protein; Validated; Region: PRK00068 698969001870 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 698969001871 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698969001872 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 698969001873 active site 698969001874 Protein of unknown function (DUF418); Region: DUF418; cl12135 698969001875 oxaloacetate decarboxylase; Provisional; Region: PRK12330 698969001876 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698969001877 active site 698969001878 catalytic residues [active] 698969001879 metal binding site [ion binding]; metal-binding site 698969001880 homodimer binding site [polypeptide binding]; other site 698969001881 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 698969001882 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698969001883 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698969001884 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698969001885 carboxyltransferase (CT) interaction site; other site 698969001886 biotinylation site [posttranslational modification]; other site 698969001887 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698969001888 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 698969001889 active site 698969001890 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698969001891 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698969001892 active site 698969001893 peptide chain release factor 2; Validated; Region: prfB; PRK00578 698969001894 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698969001895 RF-1 domain; Region: RF-1; pfam00472 698969001896 potential frameshift: common BLAST hit: gi|68535525|ref|YP_250230.1| aminobenzoyl-glutamate transporter 698969001897 AbgT putative transporter family; Region: ABG_transport; cl17431 698969001898 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 698969001899 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698969001900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969001901 Walker A/P-loop; other site 698969001902 ATP binding site [chemical binding]; other site 698969001903 Q-loop/lid; other site 698969001904 ABC transporter signature motif; other site 698969001905 Walker B; other site 698969001906 D-loop; other site 698969001907 H-loop/switch region; other site 698969001908 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 698969001909 FtsX-like permease family; Region: FtsX; pfam02687 698969001910 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 698969001911 SmpB-tmRNA interface; other site 698969001912 potential frameshift: common BLAST hit: gi|38233440|ref|NP_939207.1| transposase 698969001913 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698969001914 potential frameshift: common BLAST hit: gi|38233854|ref|NP_939621.1| transposase 698969001915 HTH-like domain; Region: HTH_21; pfam13276 698969001916 Integrase core domain; Region: rve; pfam00665 698969001917 Integrase core domain; Region: rve_2; pfam13333 698969001918 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 698969001919 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 698969001920 active site 698969001921 zinc binding site [ion binding]; other site 698969001922 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39F; cd02425 698969001923 putative active site [active] 698969001924 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698969001925 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698969001926 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698969001927 Walker A/P-loop; other site 698969001928 ATP binding site [chemical binding]; other site 698969001929 Q-loop/lid; other site 698969001930 ABC transporter signature motif; other site 698969001931 Walker B; other site 698969001932 D-loop; other site 698969001933 H-loop/switch region; other site 698969001934 Integrase core domain; Region: rve_3; pfam13683 698969001935 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698969001936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698969001937 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 698969001938 DNA-binding interface [nucleotide binding]; DNA binding site 698969001939 HTH-like domain; Region: HTH_21; pfam13276 698969001940 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698969001941 Integrase core domain; Region: rve; pfam00665 698969001942 Integrase core domain; Region: rve_3; pfam13683 698969001943 Cupin domain; Region: Cupin_2; cl17218 698969001944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698969001945 S-adenosylmethionine binding site [chemical binding]; other site 698969001946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698969001947 Integrase core domain; Region: rve_3; pfam13683 698969001948 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698969001949 Helix-turn-helix domain; Region: HTH_38; pfam13936 698969001950 Integrase core domain; Region: rve; pfam00665 698969001951 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698969001952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698969001953 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698969001954 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698969001955 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698969001956 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 698969001957 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698969001958 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698969001959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698969001960 nucleotide binding region [chemical binding]; other site 698969001961 ATP-binding site [chemical binding]; other site 698969001962 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698969001963 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698969001964 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 698969001965 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698969001966 DNA-binding site [nucleotide binding]; DNA binding site 698969001967 RNA-binding motif; other site 698969001968 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 698969001969 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 698969001970 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 698969001971 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 698969001972 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698969001973 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698969001974 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 698969001975 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698969001976 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698969001977 catalytic residue [active] 698969001978 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 698969001979 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 698969001980 dimer interface [polypeptide binding]; other site 698969001981 active site 698969001982 citrylCoA binding site [chemical binding]; other site 698969001983 NADH binding [chemical binding]; other site 698969001984 cationic pore residues; other site 698969001985 oxalacetate/citrate binding site [chemical binding]; other site 698969001986 coenzyme A binding site [chemical binding]; other site 698969001987 catalytic triad [active] 698969001988 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698969001989 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 698969001990 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698969001991 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698969001992 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698969001993 active site 698969001994 catalytic tetrad [active] 698969001995 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 698969001996 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698969001997 substrate binding site [chemical binding]; other site 698969001998 oxyanion hole (OAH) forming residues; other site 698969001999 trimer interface [polypeptide binding]; other site 698969002000 Protein of unknown function, DUF485; Region: DUF485; pfam04341 698969002001 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698969002002 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 698969002003 Na binding site [ion binding]; other site 698969002004 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 698969002005 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 698969002006 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698969002007 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 698969002008 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 698969002009 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698969002010 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 698969002011 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 698969002012 DNA methylase; Region: N6_N4_Mtase; pfam01555 698969002013 DNA methylase; Region: N6_N4_Mtase; pfam01555 698969002014 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698969002015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698969002016 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698969002017 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698969002018 active site 698969002019 Int/Topo IB signature motif; other site 698969002020 catalytic residues [active] 698969002021 DNA binding site [nucleotide binding] 698969002022 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 698969002023 active site 698969002024 SAM binding site [chemical binding]; other site 698969002025 homodimer interface [polypeptide binding]; other site 698969002026 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698969002027 catalytic residues [active] 698969002028 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 698969002029 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 698969002030 folate binding site [chemical binding]; other site 698969002031 NADP+ binding site [chemical binding]; other site 698969002032 thymidylate synthase; Reviewed; Region: thyA; PRK01827 698969002033 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 698969002034 dimerization interface [polypeptide binding]; other site 698969002035 active site 698969002036 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 698969002037 active site 698969002038 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698969002039 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 698969002040 ATP binding site [chemical binding]; other site 698969002041 putative Mg++ binding site [ion binding]; other site 698969002042 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698969002043 nucleotide binding region [chemical binding]; other site 698969002044 ATP-binding site [chemical binding]; other site 698969002045 DEAD/H associated; Region: DEAD_assoc; pfam08494 698969002046 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 698969002047 active site 698969002048 SUMO-1 interface [polypeptide binding]; other site 698969002049 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698969002050 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 698969002051 putative DNA binding site [nucleotide binding]; other site 698969002052 catalytic residue [active] 698969002053 putative H2TH interface [polypeptide binding]; other site 698969002054 putative catalytic residues [active] 698969002055 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698969002056 Predicted permease [General function prediction only]; Region: COG2985 698969002057 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698969002058 TrkA-C domain; Region: TrkA_C; pfam02080 698969002059 TrkA-C domain; Region: TrkA_C; pfam02080 698969002060 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698969002061 hypothetical protein; Provisional; Region: PRK11770 698969002062 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698969002063 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698969002064 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 698969002065 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 698969002066 active site 698969002067 dimer interface [polypeptide binding]; other site 698969002068 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 698969002069 dimer interface [polypeptide binding]; other site 698969002070 active site 698969002071 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698969002072 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698969002073 tetramerization interface [polypeptide binding]; other site 698969002074 NAD(P) binding site [chemical binding]; other site 698969002075 catalytic residues [active] 698969002076 hypothetical protein; Provisional; Region: PRK07857 698969002077 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 698969002078 Part of AAA domain; Region: AAA_19; pfam13245 698969002079 Family description; Region: UvrD_C_2; pfam13538 698969002080 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698969002081 Peptidase family M23; Region: Peptidase_M23; pfam01551 698969002082 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 698969002083 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 698969002084 active site 698969002085 substrate binding site [chemical binding]; other site 698969002086 cosubstrate binding site; other site 698969002087 catalytic site [active] 698969002088 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 698969002089 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 698969002090 purine monophosphate binding site [chemical binding]; other site 698969002091 dimer interface [polypeptide binding]; other site 698969002092 putative catalytic residues [active] 698969002093 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 698969002094 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698969002095 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 698969002096 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698969002097 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698969002098 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 698969002099 30S ribosomal protein S18; Provisional; Region: PRK13401 698969002100 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 698969002101 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 698969002102 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 698969002103 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 698969002104 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 698969002105 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698969002106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698969002107 active site 698969002108 phosphorylation site [posttranslational modification] 698969002109 intermolecular recognition site; other site 698969002110 dimerization interface [polypeptide binding]; other site 698969002111 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698969002112 DNA binding site [nucleotide binding] 698969002113 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698969002114 dimerization interface [polypeptide binding]; other site 698969002115 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698969002116 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698969002117 dimer interface [polypeptide binding]; other site 698969002118 phosphorylation site [posttranslational modification] 698969002119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698969002120 ATP binding site [chemical binding]; other site 698969002121 Mg2+ binding site [ion binding]; other site 698969002122 G-X-G motif; other site 698969002123 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698969002124 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698969002125 protein binding site [polypeptide binding]; other site 698969002126 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698969002127 MPT binding site; other site 698969002128 trimer interface [polypeptide binding]; other site 698969002129 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 698969002130 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 698969002131 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 698969002132 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 698969002133 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 698969002134 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 698969002135 active site 698969002136 tetramer interface; other site 698969002137 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698969002138 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698969002139 dimer interface [polypeptide binding]; other site 698969002140 putative functional site; other site 698969002141 putative MPT binding site; other site 698969002142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698969002143 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698969002144 Predicted membrane protein [Function unknown]; Region: COG2259 698969002145 Predicted integral membrane protein [Function unknown]; Region: COG5660 698969002146 Putative zinc-finger; Region: zf-HC2; pfam13490 698969002147 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 698969002148 BCCT family transporter; Region: BCCT; pfam02028 698969002149 Uncharacterized membrane protein [Function unknown]; Region: COG3949 698969002150 Predicted methyltransferases [General function prediction only]; Region: COG0313 698969002151 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 698969002152 putative SAM binding site [chemical binding]; other site 698969002153 putative homodimer interface [polypeptide binding]; other site 698969002154 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 698969002155 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 698969002156 active site 698969002157 HIGH motif; other site 698969002158 KMSKS motif; other site 698969002159 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 698969002160 tRNA binding surface [nucleotide binding]; other site 698969002161 anticodon binding site; other site 698969002162 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 698969002163 active site 698969002164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 698969002165 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698969002166 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698969002167 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698969002168 G5 domain; Region: G5; pfam07501 698969002169 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698969002170 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 698969002171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698969002172 S-adenosylmethionine binding site [chemical binding]; other site 698969002173 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 698969002174 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698969002175 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698969002176 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698969002177 ABC transporter; Region: ABC_tran_2; pfam12848 698969002178 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698969002179 Uncharacterized conserved protein [Function unknown]; Region: COG1359 698969002180 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698969002181 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698969002182 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698969002183 DNA binding residues [nucleotide binding] 698969002184 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698969002185 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 698969002186 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698969002187 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698969002188 active site 698969002189 motif I; other site 698969002190 motif II; other site 698969002191 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698969002192 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 698969002193 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698969002194 substrate binding site [chemical binding]; other site 698969002195 oxyanion hole (OAH) forming residues; other site 698969002196 trimer interface [polypeptide binding]; other site 698969002197 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 698969002198 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698969002199 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698969002200 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 698969002201 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 698969002202 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698969002203 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 698969002204 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 698969002205 G1 box; other site 698969002206 putative GEF interaction site [polypeptide binding]; other site 698969002207 GTP/Mg2+ binding site [chemical binding]; other site 698969002208 Switch I region; other site 698969002209 G2 box; other site 698969002210 G3 box; other site 698969002211 Switch II region; other site 698969002212 G4 box; other site 698969002213 G5 box; other site 698969002214 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 698969002215 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698969002216 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698969002217 NAD(P) binding site [chemical binding]; other site 698969002218 active site 698969002219 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698969002220 putative active site [active] 698969002221 catalytic residue [active] 698969002222 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698969002223 active site 698969002224 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698969002225 putative active site [active] 698969002226 catalytic residue [active] 698969002227 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 698969002228 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 698969002229 5S rRNA interface [nucleotide binding]; other site 698969002230 CTC domain interface [polypeptide binding]; other site 698969002231 L16 interface [polypeptide binding]; other site 698969002232 pullulanase, type I; Region: pulA_typeI; TIGR02104 698969002233 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 698969002234 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 698969002235 Ca binding site [ion binding]; other site 698969002236 active site 698969002237 catalytic site [active] 698969002238 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 698969002239 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 698969002240 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698969002241 active site 698969002242 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 698969002243 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 698969002244 Substrate binding site; other site 698969002245 Mg++ binding site; other site 698969002246 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 698969002247 active site 698969002248 substrate binding site [chemical binding]; other site 698969002249 CoA binding site [chemical binding]; other site 698969002250 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698969002251 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698969002252 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 698969002253 putative dimerization interface [polypeptide binding]; other site 698969002254 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 698969002255 gating phenylalanine in ion channel; other site 698969002256 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698969002257 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 698969002258 putative ligand binding site [chemical binding]; other site 698969002259 putative NAD binding site [chemical binding]; other site 698969002260 catalytic site [active] 698969002261 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698969002262 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698969002263 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969002264 Q-loop/lid; other site 698969002265 ABC transporter signature motif; other site 698969002266 Walker B; other site 698969002267 D-loop; other site 698969002268 H-loop/switch region; other site 698969002269 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698969002270 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698969002271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969002272 Walker A/P-loop; other site 698969002273 ATP binding site [chemical binding]; other site 698969002274 Q-loop/lid; other site 698969002275 ABC transporter signature motif; other site 698969002276 Walker B; other site 698969002277 D-loop; other site 698969002278 H-loop/switch region; other site 698969002279 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698969002280 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698969002281 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 698969002282 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 698969002283 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698969002284 ATP binding site [chemical binding]; other site 698969002285 putative Mg++ binding site [ion binding]; other site 698969002286 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698969002287 nucleotide binding region [chemical binding]; other site 698969002288 ATP-binding site [chemical binding]; other site 698969002289 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 698969002290 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 698969002291 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 698969002292 homodimer interface [polypeptide binding]; other site 698969002293 metal binding site [ion binding]; metal-binding site 698969002294 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 698969002295 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698969002296 enolase; Provisional; Region: eno; PRK00077 698969002297 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 698969002298 dimer interface [polypeptide binding]; other site 698969002299 metal binding site [ion binding]; metal-binding site 698969002300 substrate binding pocket [chemical binding]; other site 698969002301 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 698969002302 Septum formation initiator; Region: DivIC; pfam04977 698969002303 Uncharacterized conserved protein [Function unknown]; Region: COG1507 698969002304 exopolyphosphatase; Region: exo_poly_only; TIGR03706 698969002305 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698969002306 Helix-turn-helix domain; Region: HTH_18; pfam12833 698969002307 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698969002308 Bax inhibitor 1 like; Region: BaxI_1; cl17691 698969002309 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 698969002310 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 698969002311 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 698969002312 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 698969002313 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 698969002314 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 698969002315 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698969002316 catalytic residue [active] 698969002317 putative FPP diphosphate binding site; other site 698969002318 putative FPP binding hydrophobic cleft; other site 698969002319 dimer interface [polypeptide binding]; other site 698969002320 putative IPP diphosphate binding site; other site 698969002321 Flavodoxin domain; Region: Flavodoxin_5; cl17428 698969002322 pantothenate kinase; Provisional; Region: PRK05439 698969002323 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 698969002324 ATP-binding site [chemical binding]; other site 698969002325 CoA-binding site [chemical binding]; other site 698969002326 Mg2+-binding site [ion binding]; other site 698969002327 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 698969002328 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 698969002329 dimer interface [polypeptide binding]; other site 698969002330 active site 698969002331 glycine-pyridoxal phosphate binding site [chemical binding]; other site 698969002332 folate binding site [chemical binding]; other site 698969002333 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698969002334 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 698969002335 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698969002336 Coenzyme A binding pocket [chemical binding]; other site 698969002337 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698969002338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969002339 putative substrate translocation pore; other site 698969002340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969002341 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698969002342 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698969002343 fumarate hydratase; Reviewed; Region: fumC; PRK00485 698969002344 Class II fumarases; Region: Fumarase_classII; cd01362 698969002345 active site 698969002346 tetramer interface [polypeptide binding]; other site 698969002347 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 698969002348 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 698969002349 putative active site [active] 698969002350 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 698969002351 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 698969002352 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 698969002353 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 698969002354 generic binding surface II; other site 698969002355 generic binding surface I; other site 698969002356 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 698969002357 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 698969002358 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698969002359 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698969002360 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 698969002361 Na2 binding site [ion binding]; other site 698969002362 putative substrate binding site 1 [chemical binding]; other site 698969002363 Na binding site 1 [ion binding]; other site 698969002364 putative substrate binding site 2 [chemical binding]; other site 698969002365 GTP-binding protein YchF; Reviewed; Region: PRK09601 698969002366 YchF GTPase; Region: YchF; cd01900 698969002367 G1 box; other site 698969002368 GTP/Mg2+ binding site [chemical binding]; other site 698969002369 Switch I region; other site 698969002370 G2 box; other site 698969002371 Switch II region; other site 698969002372 G3 box; other site 698969002373 G4 box; other site 698969002374 G5 box; other site 698969002375 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 698969002376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 698969002377 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 698969002378 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 698969002379 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 698969002380 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 698969002381 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 698969002382 Cl- selectivity filter; other site 698969002383 Cl- binding residues [ion binding]; other site 698969002384 pore gating glutamate residue; other site 698969002385 dimer interface [polypeptide binding]; other site 698969002386 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698969002387 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698969002388 Walker A/P-loop; other site 698969002389 ATP binding site [chemical binding]; other site 698969002390 Q-loop/lid; other site 698969002391 ABC transporter signature motif; other site 698969002392 Walker B; other site 698969002393 D-loop; other site 698969002394 H-loop/switch region; other site 698969002395 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 698969002396 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698969002397 Walker A/P-loop; other site 698969002398 ATP binding site [chemical binding]; other site 698969002399 Q-loop/lid; other site 698969002400 ABC transporter signature motif; other site 698969002401 Walker B; other site 698969002402 D-loop; other site 698969002403 H-loop/switch region; other site 698969002404 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698969002405 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 698969002406 active site 698969002407 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698969002408 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698969002409 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698969002410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698969002411 dimer interface [polypeptide binding]; other site 698969002412 conserved gate region; other site 698969002413 ABC-ATPase subunit interface; other site 698969002414 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698969002415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698969002416 dimer interface [polypeptide binding]; other site 698969002417 conserved gate region; other site 698969002418 putative PBP binding loops; other site 698969002419 ABC-ATPase subunit interface; other site 698969002420 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698969002421 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698969002422 Walker A/P-loop; other site 698969002423 ATP binding site [chemical binding]; other site 698969002424 Q-loop/lid; other site 698969002425 ABC transporter signature motif; other site 698969002426 Walker B; other site 698969002427 D-loop; other site 698969002428 H-loop/switch region; other site 698969002429 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698969002430 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698969002431 Walker A/P-loop; other site 698969002432 ATP binding site [chemical binding]; other site 698969002433 Q-loop/lid; other site 698969002434 ABC transporter signature motif; other site 698969002435 Walker B; other site 698969002436 D-loop; other site 698969002437 H-loop/switch region; other site 698969002438 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698969002439 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698969002440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969002441 Walker A/P-loop; other site 698969002442 ATP binding site [chemical binding]; other site 698969002443 ABC transporter signature motif; other site 698969002444 Walker B; other site 698969002445 D-loop; other site 698969002446 H-loop/switch region; other site 698969002447 Trypsin; Region: Trypsin; pfam00089 698969002448 active site 698969002449 substrate binding sites [chemical binding]; other site 698969002450 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 698969002451 ArsC family; Region: ArsC; pfam03960 698969002452 catalytic residues [active] 698969002453 Protein of unknown function (DUF402); Region: DUF402; cl00979 698969002454 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 698969002455 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 698969002456 G1 box; other site 698969002457 GTP/Mg2+ binding site [chemical binding]; other site 698969002458 G2 box; other site 698969002459 Switch I region; other site 698969002460 G3 box; other site 698969002461 Switch II region; other site 698969002462 G4 box; other site 698969002463 G5 box; other site 698969002464 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 698969002465 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 698969002466 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 698969002467 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698969002468 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 698969002469 Ferredoxin [Energy production and conversion]; Region: COG1146 698969002470 4Fe-4S binding domain; Region: Fer4; pfam00037 698969002471 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 698969002472 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698969002473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698969002474 homodimer interface [polypeptide binding]; other site 698969002475 catalytic residue [active] 698969002476 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698969002477 active site 698969002478 Predicted membrane protein [Function unknown]; Region: COG2246 698969002479 GtrA-like protein; Region: GtrA; pfam04138 698969002480 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698969002481 active site 698969002482 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 698969002483 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698969002484 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 698969002485 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 698969002486 putative trimer interface [polypeptide binding]; other site 698969002487 putative CoA binding site [chemical binding]; other site 698969002488 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 698969002489 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698969002490 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 698969002491 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698969002492 putative trimer interface [polypeptide binding]; other site 698969002493 putative CoA binding site [chemical binding]; other site 698969002494 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 698969002495 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 698969002496 metal binding site [ion binding]; metal-binding site 698969002497 putative dimer interface [polypeptide binding]; other site 698969002498 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698969002499 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698969002500 dihydropteroate synthase; Region: DHPS; TIGR01496 698969002501 substrate binding pocket [chemical binding]; other site 698969002502 dimer interface [polypeptide binding]; other site 698969002503 inhibitor binding site; inhibition site 698969002504 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 698969002505 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 698969002506 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 698969002507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698969002508 S-adenosylmethionine binding site [chemical binding]; other site 698969002509 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 698969002510 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 698969002511 active site 698969002512 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 698969002513 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 698969002514 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 698969002515 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698969002516 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 698969002517 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 698969002518 ligand binding site; other site 698969002519 oligomer interface; other site 698969002520 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 698969002521 dimer interface [polypeptide binding]; other site 698969002522 N-terminal domain interface [polypeptide binding]; other site 698969002523 sulfate 1 binding site; other site 698969002524 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 698969002525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698969002526 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 698969002527 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698969002528 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698969002529 DNA binding residues [nucleotide binding] 698969002530 Putative zinc-finger; Region: zf-HC2; pfam13490 698969002531 sec-independent translocase; Provisional; Region: tatB; PRK00182 698969002532 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 698969002533 Domain of unknown function DUF59; Region: DUF59; pfam01883 698969002534 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 698969002535 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 698969002536 Predicted membrane protein [Function unknown]; Region: COG4420 698969002537 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 698969002538 MgtE intracellular N domain; Region: MgtE_N; smart00924 698969002539 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 698969002540 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 698969002541 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698969002542 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 698969002543 TPP-binding site [chemical binding]; other site 698969002544 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 698969002545 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698969002546 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698969002547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969002548 Walker A/P-loop; other site 698969002549 ATP binding site [chemical binding]; other site 698969002550 Q-loop/lid; other site 698969002551 ABC transporter signature motif; other site 698969002552 Walker B; other site 698969002553 D-loop; other site 698969002554 H-loop/switch region; other site 698969002555 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698969002556 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698969002557 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969002558 Walker A/P-loop; other site 698969002559 ATP binding site [chemical binding]; other site 698969002560 Q-loop/lid; other site 698969002561 ABC transporter signature motif; other site 698969002562 Walker B; other site 698969002563 D-loop; other site 698969002564 H-loop/switch region; other site 698969002565 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 698969002566 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698969002567 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698969002568 shikimate binding site; other site 698969002569 NAD(P) binding site [chemical binding]; other site 698969002570 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698969002571 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698969002572 substrate binding pocket [chemical binding]; other site 698969002573 catalytic triad [active] 698969002574 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 698969002575 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 698969002576 active site 698969002577 catalytic residues [active] 698969002578 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698969002579 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 698969002580 Na binding site [ion binding]; other site 698969002581 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698969002582 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 698969002583 nucleotide binding site/active site [active] 698969002584 HIT family signature motif; other site 698969002585 catalytic residue [active] 698969002586 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 698969002587 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698969002588 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698969002589 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698969002590 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 698969002591 PLD-like domain; Region: PLDc_2; pfam13091 698969002592 putative homodimer interface [polypeptide binding]; other site 698969002593 putative active site [active] 698969002594 catalytic site [active] 698969002595 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698969002596 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698969002597 putative Mg++ binding site [ion binding]; other site 698969002598 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698969002599 nucleotide binding region [chemical binding]; other site 698969002600 ATP-binding site [chemical binding]; other site 698969002601 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 698969002602 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 698969002603 active site 698969002604 8-oxo-dGMP binding site [chemical binding]; other site 698969002605 nudix motif; other site 698969002606 metal binding site [ion binding]; metal-binding site 698969002607 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 698969002608 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698969002609 ATP binding site [chemical binding]; other site 698969002610 Mg++ binding site [ion binding]; other site 698969002611 motif III; other site 698969002612 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698969002613 nucleotide binding region [chemical binding]; other site 698969002614 ATP-binding site [chemical binding]; other site 698969002615 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 698969002616 putative RNA binding site [nucleotide binding]; other site 698969002617 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698969002618 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698969002619 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 698969002620 Na binding site [ion binding]; other site 698969002621 SNF2 Helicase protein; Region: DUF3670; pfam12419 698969002622 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 698969002623 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698969002624 ATP binding site [chemical binding]; other site 698969002625 putative Mg++ binding site [ion binding]; other site 698969002626 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698969002627 nucleotide binding region [chemical binding]; other site 698969002628 ATP-binding site [chemical binding]; other site 698969002629 Uncharacterized conserved protein [Function unknown]; Region: COG4279 698969002630 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 698969002631 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 698969002632 active site 698969002633 metal binding site [ion binding]; metal-binding site 698969002634 DNA binding site [nucleotide binding] 698969002635 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 698969002636 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969002637 Walker A/P-loop; other site 698969002638 ATP binding site [chemical binding]; other site 698969002639 Q-loop/lid; other site 698969002640 Uncharacterized conserved protein [Function unknown]; Region: COG2353 698969002641 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698969002642 MarR family; Region: MarR_2; pfam12802 698969002643 PspC domain; Region: PspC; cl00864 698969002644 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698969002645 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 698969002646 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698969002647 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 698969002648 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698969002649 Cysteine-rich domain; Region: CCG; pfam02754 698969002650 Cysteine-rich domain; Region: CCG; pfam02754 698969002651 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698969002652 L-lactate permease; Region: Lactate_perm; cl00701 698969002653 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 698969002654 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 698969002655 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 698969002656 active site 698969002657 HIGH motif; other site 698969002658 KMSK motif region; other site 698969002659 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 698969002660 tRNA binding surface [nucleotide binding]; other site 698969002661 anticodon binding site; other site 698969002662 diaminopimelate decarboxylase; Region: lysA; TIGR01048 698969002663 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 698969002664 active site 698969002665 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698969002666 substrate binding site [chemical binding]; other site 698969002667 catalytic residues [active] 698969002668 dimer interface [polypeptide binding]; other site 698969002669 homoserine dehydrogenase; Provisional; Region: PRK06349 698969002670 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 698969002671 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 698969002672 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 698969002673 homoserine kinase; Provisional; Region: PRK01212 698969002674 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 698969002675 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698969002676 acyl-activating enzyme (AAE) consensus motif; other site 698969002677 AMP binding site [chemical binding]; other site 698969002678 active site 698969002679 CoA binding site [chemical binding]; other site 698969002680 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 698969002681 transcription termination factor Rho; Provisional; Region: PRK12608 698969002682 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698969002683 RNA binding site [nucleotide binding]; other site 698969002684 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 698969002685 multimer interface [polypeptide binding]; other site 698969002686 Walker A motif; other site 698969002687 ATP binding site [chemical binding]; other site 698969002688 Walker B motif; other site 698969002689 peptide chain release factor 1; Validated; Region: prfA; PRK00591 698969002690 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698969002691 RF-1 domain; Region: RF-1; pfam00472 698969002692 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 698969002693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698969002694 S-adenosylmethionine binding site [chemical binding]; other site 698969002695 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 698969002696 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 698969002697 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 698969002698 Mg++ binding site [ion binding]; other site 698969002699 putative catalytic motif [active] 698969002700 substrate binding site [chemical binding]; other site 698969002701 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 698969002702 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 698969002703 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 698969002704 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 698969002705 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 698969002706 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 698969002707 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 698969002708 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 698969002709 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698969002710 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 698969002711 beta subunit interaction interface [polypeptide binding]; other site 698969002712 Walker A motif; other site 698969002713 ATP binding site [chemical binding]; other site 698969002714 Walker B motif; other site 698969002715 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698969002716 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 698969002717 core domain interface [polypeptide binding]; other site 698969002718 delta subunit interface [polypeptide binding]; other site 698969002719 epsilon subunit interface [polypeptide binding]; other site 698969002720 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 698969002721 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698969002722 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 698969002723 alpha subunit interaction interface [polypeptide binding]; other site 698969002724 Walker A motif; other site 698969002725 ATP binding site [chemical binding]; other site 698969002726 Walker B motif; other site 698969002727 inhibitor binding site; inhibition site 698969002728 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698969002729 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 698969002730 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 698969002731 gamma subunit interface [polypeptide binding]; other site 698969002732 epsilon subunit interface [polypeptide binding]; other site 698969002733 LBP interface [polypeptide binding]; other site 698969002734 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 698969002735 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 698969002736 hypothetical protein; Provisional; Region: PRK03298 698969002737 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 698969002738 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698969002739 dimer interface [polypeptide binding]; other site 698969002740 substrate binding site [chemical binding]; other site 698969002741 metal binding site [ion binding]; metal-binding site 698969002742 Domain of unknown function DUF77; Region: DUF77; pfam01910 698969002743 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698969002744 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698969002745 Walker A/P-loop; other site 698969002746 ATP binding site [chemical binding]; other site 698969002747 Q-loop/lid; other site 698969002748 ABC transporter signature motif; other site 698969002749 Walker B; other site 698969002750 D-loop; other site 698969002751 H-loop/switch region; other site 698969002752 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698969002753 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698969002754 ABC-ATPase subunit interface; other site 698969002755 dimer interface [polypeptide binding]; other site 698969002756 putative PBP binding regions; other site 698969002757 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698969002758 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698969002759 ABC-ATPase subunit interface; other site 698969002760 dimer interface [polypeptide binding]; other site 698969002761 putative PBP binding regions; other site 698969002762 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 698969002763 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698969002764 siderophore binding site; other site 698969002765 TIGR02611 family protein; Region: TIGR02611 698969002766 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 698969002767 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 698969002768 glycogen branching enzyme; Provisional; Region: PRK05402 698969002769 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 698969002770 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 698969002771 active site 698969002772 catalytic site [active] 698969002773 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 698969002774 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 698969002775 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 698969002776 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698969002777 active site 698969002778 homodimer interface [polypeptide binding]; other site 698969002779 catalytic site [active] 698969002780 acceptor binding site [chemical binding]; other site 698969002781 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698969002782 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969002783 Walker A/P-loop; other site 698969002784 ATP binding site [chemical binding]; other site 698969002785 Q-loop/lid; other site 698969002786 ABC transporter signature motif; other site 698969002787 Walker B; other site 698969002788 D-loop; other site 698969002789 H-loop/switch region; other site 698969002790 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 698969002791 Ligand binding site [chemical binding]; other site 698969002792 Electron transfer flavoprotein domain; Region: ETF; pfam01012 698969002793 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 698969002794 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 698969002795 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 698969002796 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 698969002797 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 698969002798 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698969002799 catalytic residue [active] 698969002800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698969002801 S-adenosylmethionine binding site [chemical binding]; other site 698969002802 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 698969002803 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 698969002804 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698969002805 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698969002806 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698969002807 active site 698969002808 catalytic site [active] 698969002809 substrate binding site [chemical binding]; other site 698969002810 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 698969002811 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 698969002812 nucleotide binding pocket [chemical binding]; other site 698969002813 K-X-D-G motif; other site 698969002814 catalytic site [active] 698969002815 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 698969002816 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 698969002817 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 698969002818 Dimer interface [polypeptide binding]; other site 698969002819 BRCT sequence motif; other site 698969002820 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698969002821 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 698969002822 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698969002823 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 698969002824 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 698969002825 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698969002826 Coenzyme A binding pocket [chemical binding]; other site 698969002827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969002828 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698969002829 putative substrate translocation pore; other site 698969002830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969002831 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698969002832 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698969002833 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698969002834 ABC-ATPase subunit interface; other site 698969002835 dimer interface [polypeptide binding]; other site 698969002836 putative PBP binding regions; other site 698969002837 proposed F420-0 ABC transporter, ATP-binding protein; Region: F420-0_ABC_ATP; TIGR03873 698969002838 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969002839 Walker A/P-loop; other site 698969002840 ATP binding site [chemical binding]; other site 698969002841 Q-loop/lid; other site 698969002842 ABC transporter signature motif; other site 698969002843 Walker B; other site 698969002844 D-loop; other site 698969002845 H-loop/switch region; other site 698969002846 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 698969002847 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 698969002848 putative ligand binding residues [chemical binding]; other site 698969002849 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 698969002850 phosphofructokinase; Region: PFK_mixed; TIGR02483 698969002851 active site 698969002852 ADP/pyrophosphate binding site [chemical binding]; other site 698969002853 dimerization interface [polypeptide binding]; other site 698969002854 allosteric effector site; other site 698969002855 fructose-1,6-bisphosphate binding site; other site 698969002856 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 698969002857 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 698969002858 GatB domain; Region: GatB_Yqey; smart00845 698969002859 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698969002860 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698969002861 active site 698969002862 catalytic tetrad [active] 698969002863 Lysine efflux permease [General function prediction only]; Region: COG1279 698969002864 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 698969002865 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698969002866 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698969002867 dimerization interface [polypeptide binding]; other site 698969002868 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 698969002869 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 698969002870 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 698969002871 putative dimer interface [polypeptide binding]; other site 698969002872 N-terminal domain interface [polypeptide binding]; other site 698969002873 putative substrate binding pocket (H-site) [chemical binding]; other site 698969002874 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698969002875 Predicted membrane protein [Function unknown]; Region: COG2259 698969002876 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 698969002877 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698969002878 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 698969002879 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698969002880 PYR/PP interface [polypeptide binding]; other site 698969002881 dimer interface [polypeptide binding]; other site 698969002882 TPP binding site [chemical binding]; other site 698969002883 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698969002884 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 698969002885 TPP-binding site [chemical binding]; other site 698969002886 dimer interface [polypeptide binding]; other site 698969002887 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 698969002888 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 698969002889 putative valine binding site [chemical binding]; other site 698969002890 dimer interface [polypeptide binding]; other site 698969002891 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 698969002892 ketol-acid reductoisomerase; Provisional; Region: PRK05479 698969002893 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 698969002894 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 698969002895 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 698969002896 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 698969002897 Uncharacterized conserved protein [Function unknown]; Region: COG1479 698969002898 Protein of unknown function DUF262; Region: DUF262; pfam03235 698969002899 Uncharacterized conserved protein [Function unknown]; Region: COG3472 698969002900 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 698969002901 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 698969002902 ligand binding site [chemical binding]; other site 698969002903 NAD binding site [chemical binding]; other site 698969002904 dimerization interface [polypeptide binding]; other site 698969002905 catalytic site [active] 698969002906 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 698969002907 putative L-serine binding site [chemical binding]; other site 698969002908 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 698969002909 tartrate dehydrogenase; Region: TTC; TIGR02089 698969002910 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698969002911 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698969002912 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698969002913 metal binding triad; other site 698969002914 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 698969002915 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698969002916 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698969002917 catalytic site [active] 698969002918 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 698969002919 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 698969002920 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 698969002921 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 698969002922 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698969002923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698969002924 S-adenosylmethionine binding site [chemical binding]; other site 698969002925 isochorismate synthase DhbC; Validated; Region: PRK06923 698969002926 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698969002927 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 698969002928 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698969002929 active site 698969002930 HIGH motif; other site 698969002931 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698969002932 active site 698969002933 KMSKS motif; other site 698969002934 Predicted esterase [General function prediction only]; Region: COG0400 698969002935 MMPL family; Region: MMPL; pfam03176 698969002936 Ethanolamine utilisation protein, EutH; Region: EutH; cl01248 698969002937 Cutinase; Region: Cutinase; pfam01083 698969002938 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 698969002939 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 698969002940 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 698969002941 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 698969002942 PhnA protein; Region: PhnA; pfam03831 698969002943 biotin synthase; Region: bioB; TIGR00433 698969002944 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698969002945 FeS/SAM binding site; other site 698969002946 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698969002947 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698969002948 HD domain; Region: HD_4; pfam13328 698969002949 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698969002950 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698969002951 putative DNA binding site [nucleotide binding]; other site 698969002952 putative Zn2+ binding site [ion binding]; other site 698969002953 Bacterial transcriptional regulator; Region: IclR; pfam01614 698969002954 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 698969002955 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 698969002956 substrate binding site [chemical binding]; other site 698969002957 ligand binding site [chemical binding]; other site 698969002958 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 698969002959 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 698969002960 substrate binding site [chemical binding]; other site 698969002961 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698969002962 active site 698969002963 Ap6A binding site [chemical binding]; other site 698969002964 nudix motif; other site 698969002965 metal binding site [ion binding]; metal-binding site 698969002966 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698969002967 catalytic core [active] 698969002968 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 698969002969 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698969002970 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 698969002971 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 698969002972 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 698969002973 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698969002974 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698969002975 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698969002976 thiamine monophosphate kinase; Provisional; Region: PRK05731 698969002977 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 698969002978 ATP binding site [chemical binding]; other site 698969002979 dimerization interface [polypeptide binding]; other site 698969002980 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 698969002981 ligand binding site [chemical binding]; other site 698969002982 active site 698969002983 UGI interface [polypeptide binding]; other site 698969002984 catalytic site [active] 698969002985 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 698969002986 DAK2 domain; Region: Dak2; pfam02734 698969002987 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 698969002988 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 698969002989 generic binding surface II; other site 698969002990 ssDNA binding site; other site 698969002991 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698969002992 ATP binding site [chemical binding]; other site 698969002993 putative Mg++ binding site [ion binding]; other site 698969002994 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698969002995 nucleotide binding region [chemical binding]; other site 698969002996 ATP-binding site [chemical binding]; other site 698969002997 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698969002998 carboxyltransferase (CT) interaction site; other site 698969002999 biotinylation site [posttranslational modification]; other site 698969003000 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 698969003001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698969003002 S-adenosylmethionine binding site [chemical binding]; other site 698969003003 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 698969003004 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 698969003005 active site 698969003006 (T/H)XGH motif; other site 698969003007 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698969003008 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698969003009 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698969003010 Walker A/P-loop; other site 698969003011 ATP binding site [chemical binding]; other site 698969003012 Q-loop/lid; other site 698969003013 ABC transporter signature motif; other site 698969003014 Walker B; other site 698969003015 D-loop; other site 698969003016 H-loop/switch region; other site 698969003017 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698969003018 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698969003019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698969003020 dimer interface [polypeptide binding]; other site 698969003021 conserved gate region; other site 698969003022 putative PBP binding loops; other site 698969003023 ABC-ATPase subunit interface; other site 698969003024 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698969003025 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698969003026 substrate binding pocket [chemical binding]; other site 698969003027 membrane-bound complex binding site; other site 698969003028 hinge residues; other site 698969003029 Domain of unknown function (DUF368); Region: DUF368; pfam04018 698969003030 DNA polymerase I; Provisional; Region: PRK05755 698969003031 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 698969003032 active site 698969003033 metal binding site 1 [ion binding]; metal-binding site 698969003034 putative 5' ssDNA interaction site; other site 698969003035 metal binding site 3; metal-binding site 698969003036 metal binding site 2 [ion binding]; metal-binding site 698969003037 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 698969003038 putative DNA binding site [nucleotide binding]; other site 698969003039 putative metal binding site [ion binding]; other site 698969003040 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 698969003041 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 698969003042 active site 698969003043 DNA binding site [nucleotide binding] 698969003044 catalytic site [active] 698969003045 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698969003046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698969003047 S-adenosylmethionine binding site [chemical binding]; other site 698969003048 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 698969003049 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 698969003050 RNA binding site [nucleotide binding]; other site 698969003051 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 698969003052 RNA binding site [nucleotide binding]; other site 698969003053 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698969003054 RNA binding site [nucleotide binding]; other site 698969003055 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 698969003056 RNA binding site [nucleotide binding]; other site 698969003057 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 698969003058 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 698969003059 transcriptional antiterminator BglG; Provisional; Region: PRK09772 698969003060 CAT RNA binding domain; Region: CAT_RBD; smart01061 698969003061 PRD domain; Region: PRD; pfam00874 698969003062 PRD domain; Region: PRD; pfam00874 698969003063 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 698969003064 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698969003065 active site turn [active] 698969003066 phosphorylation site [posttranslational modification] 698969003067 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698969003068 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 698969003069 HPr interaction site; other site 698969003070 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698969003071 active site 698969003072 phosphorylation site [posttranslational modification] 698969003073 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 698969003074 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 698969003075 CoA-binding site [chemical binding]; other site 698969003076 ATP-binding [chemical binding]; other site 698969003077 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 698969003078 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698969003079 FeS/SAM binding site; other site 698969003080 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 698969003081 excinuclease ABC subunit B; Provisional; Region: PRK05298 698969003082 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698969003083 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698969003084 nucleotide binding region [chemical binding]; other site 698969003085 ATP-binding site [chemical binding]; other site 698969003086 Ultra-violet resistance protein B; Region: UvrB; pfam12344 698969003087 UvrB/uvrC motif; Region: UVR; pfam02151 698969003088 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698969003089 Ligand Binding Site [chemical binding]; other site 698969003090 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 698969003091 Part of AAA domain; Region: AAA_19; pfam13245 698969003092 PhoH-like protein; Region: PhoH; cl17668 698969003093 Family description; Region: UvrD_C_2; pfam13538 698969003094 Predicted membrane protein [Function unknown]; Region: COG2259 698969003095 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698969003096 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 698969003097 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698969003098 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698969003099 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 698969003100 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 698969003101 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 698969003102 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 698969003103 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 698969003104 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 698969003105 23S rRNA binding site [nucleotide binding]; other site 698969003106 L21 binding site [polypeptide binding]; other site 698969003107 L13 binding site [polypeptide binding]; other site 698969003108 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698969003109 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 698969003110 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698969003111 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 698969003112 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 698969003113 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 698969003114 dimer interface [polypeptide binding]; other site 698969003115 motif 1; other site 698969003116 active site 698969003117 motif 2; other site 698969003118 motif 3; other site 698969003119 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 698969003120 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 698969003121 putative tRNA-binding site [nucleotide binding]; other site 698969003122 B3/4 domain; Region: B3_4; pfam03483 698969003123 tRNA synthetase B5 domain; Region: B5; smart00874 698969003124 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 698969003125 dimer interface [polypeptide binding]; other site 698969003126 motif 1; other site 698969003127 motif 3; other site 698969003128 motif 2; other site 698969003129 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 698969003130 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 698969003131 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698969003132 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 698969003133 heterotetramer interface [polypeptide binding]; other site 698969003134 active site pocket [active] 698969003135 cleavage site 698969003136 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 698969003137 feedback inhibition sensing region; other site 698969003138 homohexameric interface [polypeptide binding]; other site 698969003139 nucleotide binding site [chemical binding]; other site 698969003140 N-acetyl-L-glutamate binding site [chemical binding]; other site 698969003141 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 698969003142 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698969003143 inhibitor-cofactor binding pocket; inhibition site 698969003144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698969003145 catalytic residue [active] 698969003146 ornithine carbamoyltransferase; Provisional; Region: PRK00779 698969003147 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698969003148 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698969003149 arginine repressor; Provisional; Region: PRK03341 698969003150 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 698969003151 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 698969003152 argininosuccinate synthase; Provisional; Region: PRK13820 698969003153 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 698969003154 ANP binding site [chemical binding]; other site 698969003155 Substrate Binding Site II [chemical binding]; other site 698969003156 Substrate Binding Site I [chemical binding]; other site 698969003157 argininosuccinate lyase; Provisional; Region: PRK00855 698969003158 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 698969003159 active sites [active] 698969003160 tetramer interface [polypeptide binding]; other site 698969003161 Uncharacterized conserved protein [Function unknown]; Region: COG2835 698969003162 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 698969003163 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 698969003164 active site 698969003165 HIGH motif; other site 698969003166 dimer interface [polypeptide binding]; other site 698969003167 KMSKS motif; other site 698969003168 S4 RNA-binding domain; Region: S4; smart00363 698969003169 transcription termination factor Rho; Provisional; Region: PRK12678 698969003170 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 698969003171 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698969003172 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698969003173 active site 698969003174 motif I; other site 698969003175 motif II; other site 698969003176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698969003177 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 698969003178 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698969003179 RNA binding surface [nucleotide binding]; other site 698969003180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698969003181 S-adenosylmethionine binding site [chemical binding]; other site 698969003182 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 698969003183 ATP-NAD kinase; Region: NAD_kinase; pfam01513 698969003184 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 698969003185 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698969003186 Walker A/P-loop; other site 698969003187 ATP binding site [chemical binding]; other site 698969003188 Q-loop/lid; other site 698969003189 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698969003190 ABC transporter signature motif; other site 698969003191 Walker B; other site 698969003192 D-loop; other site 698969003193 H-loop/switch region; other site 698969003194 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 698969003195 Thiamine pyrophosphokinase; Region: TPK; cl08415 698969003196 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 698969003197 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 698969003198 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 698969003199 dimer interface [polypeptide binding]; other site 698969003200 ADP-ribose binding site [chemical binding]; other site 698969003201 active site 698969003202 nudix motif; other site 698969003203 metal binding site [ion binding]; metal-binding site 698969003204 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 698969003205 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 698969003206 active site 698969003207 Int/Topo IB signature motif; other site 698969003208 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698969003209 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698969003210 P-loop; other site 698969003211 Magnesium ion binding site [ion binding]; other site 698969003212 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698969003213 Magnesium ion binding site [ion binding]; other site 698969003214 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 698969003215 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698969003216 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 698969003217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969003218 POT family; Region: PTR2; cl17359 698969003219 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 698969003220 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698969003221 inhibitor-cofactor binding pocket; inhibition site 698969003222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698969003223 catalytic residue [active] 698969003224 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698969003225 AAA domain; Region: AAA_26; pfam13500 698969003226 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 698969003227 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 698969003228 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698969003229 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698969003230 RNA binding surface [nucleotide binding]; other site 698969003231 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 698969003232 active site 698969003233 cytidylate kinase; Provisional; Region: cmk; PRK00023 698969003234 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 698969003235 CMP-binding site; other site 698969003236 The sites determining sugar specificity; other site 698969003237 GTP-binding protein Der; Reviewed; Region: PRK03003 698969003238 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 698969003239 G1 box; other site 698969003240 GTP/Mg2+ binding site [chemical binding]; other site 698969003241 Switch I region; other site 698969003242 G2 box; other site 698969003243 Switch II region; other site 698969003244 G3 box; other site 698969003245 G4 box; other site 698969003246 G5 box; other site 698969003247 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 698969003248 G1 box; other site 698969003249 GTP/Mg2+ binding site [chemical binding]; other site 698969003250 Switch I region; other site 698969003251 G2 box; other site 698969003252 G3 box; other site 698969003253 Switch II region; other site 698969003254 G4 box; other site 698969003255 G5 box; other site 698969003256 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698969003257 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 698969003258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698969003259 S-adenosylmethionine binding site [chemical binding]; other site 698969003260 Putative esterase; Region: Esterase; pfam00756 698969003261 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698969003262 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 698969003263 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698969003264 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 698969003265 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698969003266 nucleotide binding region [chemical binding]; other site 698969003267 ATP-binding site [chemical binding]; other site 698969003268 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698969003269 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698969003270 phosphopeptide binding site; other site 698969003271 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 698969003272 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698969003273 DNA binding residues [nucleotide binding] 698969003274 Bifunctional nuclease; Region: DNase-RNase; pfam02577 698969003275 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 698969003276 DNA binding residues [nucleotide binding] 698969003277 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698969003278 putative dimer interface [polypeptide binding]; other site 698969003279 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698969003280 metal ion-dependent adhesion site (MIDAS); other site 698969003281 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698969003282 Domain of unknown function DUF21; Region: DUF21; pfam01595 698969003283 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698969003284 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698969003285 Domain of unknown function DUF21; Region: DUF21; pfam01595 698969003286 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698969003287 Transporter associated domain; Region: CorC_HlyC; smart01091 698969003288 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 698969003289 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698969003290 ATP binding site [chemical binding]; other site 698969003291 Mg++ binding site [ion binding]; other site 698969003292 motif III; other site 698969003293 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698969003294 nucleotide binding region [chemical binding]; other site 698969003295 ATP-binding site [chemical binding]; other site 698969003296 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698969003297 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 698969003298 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 698969003299 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 698969003300 CoenzymeA binding site [chemical binding]; other site 698969003301 subunit interaction site [polypeptide binding]; other site 698969003302 PHB binding site; other site 698969003303 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 698969003304 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 698969003305 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 698969003306 oligomer interface [polypeptide binding]; other site 698969003307 metal binding site [ion binding]; metal-binding site 698969003308 metal binding site [ion binding]; metal-binding site 698969003309 putative Cl binding site [ion binding]; other site 698969003310 basic sphincter; other site 698969003311 hydrophobic gate; other site 698969003312 periplasmic entrance; other site 698969003313 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698969003314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698969003315 S-adenosylmethionine binding site [chemical binding]; other site 698969003316 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698969003317 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698969003318 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698969003319 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 698969003320 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698969003321 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 698969003322 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698969003323 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 698969003324 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698969003325 FAD binding domain; Region: FAD_binding_4; pfam01565 698969003326 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698969003327 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698969003328 Sodium Bile acid symporter family; Region: SBF; pfam01758 698969003329 YceI-like domain; Region: YceI; pfam04264 698969003330 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 698969003331 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 698969003332 Ligand binding site; other site 698969003333 Putative Catalytic site; other site 698969003334 DXD motif; other site 698969003335 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 698969003336 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 698969003337 putative active site [active] 698969003338 catalytic triad [active] 698969003339 putative dimer interface [polypeptide binding]; other site 698969003340 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 698969003341 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 698969003342 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698969003343 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698969003344 precorrin-3B synthase; Region: CobG; TIGR02435 698969003345 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698969003346 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698969003347 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 698969003348 Precorrin-8X methylmutase; Region: CbiC; pfam02570 698969003349 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 698969003350 active site 698969003351 SAM binding site [chemical binding]; other site 698969003352 homodimer interface [polypeptide binding]; other site 698969003353 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 698969003354 active site 698969003355 SAM binding site [chemical binding]; other site 698969003356 homodimer interface [polypeptide binding]; other site 698969003357 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 698969003358 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 698969003359 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 698969003360 active site 698969003361 SAM binding site [chemical binding]; other site 698969003362 homodimer interface [polypeptide binding]; other site 698969003363 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 698969003364 active site 698969003365 putative homodimer interface [polypeptide binding]; other site 698969003366 SAM binding site [chemical binding]; other site 698969003367 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 698969003368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698969003369 S-adenosylmethionine binding site [chemical binding]; other site 698969003370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698969003371 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698969003372 NAD(P) binding site [chemical binding]; other site 698969003373 active site 698969003374 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698969003375 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698969003376 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698969003377 active site 698969003378 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698969003379 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698969003380 ATP binding site [chemical binding]; other site 698969003381 putative Mg++ binding site [ion binding]; other site 698969003382 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698969003383 nucleotide binding region [chemical binding]; other site 698969003384 ATP-binding site [chemical binding]; other site 698969003385 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 698969003386 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 698969003387 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 698969003388 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 698969003389 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 698969003390 Predicted transcriptional regulator [Transcription]; Region: COG2378 698969003391 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 698969003392 WYL domain; Region: WYL; pfam13280 698969003393 WYL domain; Region: WYL; pfam13280 698969003394 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 698969003395 Pup-like protein; Region: Pup; pfam05639 698969003396 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 698969003397 proteasome ATPase; Region: pup_AAA; TIGR03689 698969003398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698969003399 Walker A motif; other site 698969003400 ATP binding site [chemical binding]; other site 698969003401 Walker B motif; other site 698969003402 arginine finger; other site 698969003403 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 698969003404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698969003405 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 698969003406 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 698969003407 active site 698969003408 metal binding site [ion binding]; metal-binding site 698969003409 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 698969003410 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 698969003411 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 698969003412 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 698969003413 Potassium binding sites [ion binding]; other site 698969003414 Cesium cation binding sites [ion binding]; other site 698969003415 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 698969003416 Aspartase; Region: Aspartase; cd01357 698969003417 active sites [active] 698969003418 tetramer interface [polypeptide binding]; other site 698969003419 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698969003420 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 698969003421 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 698969003422 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 698969003423 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 698969003424 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 698969003425 homodimer interface [polypeptide binding]; other site 698969003426 putative metal binding site [ion binding]; other site 698969003427 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 698969003428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698969003429 motif II; other site 698969003430 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 698969003431 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 698969003432 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 698969003433 substrate binding pocket [chemical binding]; other site 698969003434 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 698969003435 B12 binding site [chemical binding]; other site 698969003436 cobalt ligand [ion binding]; other site 698969003437 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 698969003438 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 698969003439 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698969003440 active site 698969003441 HIGH motif; other site 698969003442 nucleotide binding site [chemical binding]; other site 698969003443 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698969003444 active site 698969003445 KMSKS motif; other site 698969003446 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698969003447 tRNA binding surface [nucleotide binding]; other site 698969003448 anticodon binding site; other site 698969003449 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 698969003450 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 698969003451 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 698969003452 quinone interaction residues [chemical binding]; other site 698969003453 active site 698969003454 catalytic residues [active] 698969003455 FMN binding site [chemical binding]; other site 698969003456 substrate binding site [chemical binding]; other site 698969003457 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 698969003458 substrate binding site [chemical binding]; other site 698969003459 potential frameshift: common BLAST hit: gi|38233440|ref|NP_939207.1| transposase 698969003460 Integrase core domain; Region: rve_2; pfam13333 698969003461 potential frameshift: common BLAST hit: gi|38233854|ref|NP_939621.1| transposase 698969003462 HTH-like domain; Region: HTH_21; pfam13276 698969003463 Integrase core domain; Region: rve; pfam00665 698969003464 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698969003465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698969003466 active site 698969003467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698969003468 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698969003469 active site residue [active] 698969003470 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698969003471 active site residue [active] 698969003472 membrane ATPase/protein kinase; Provisional; Region: PRK09435 698969003473 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 698969003474 Walker A; other site 698969003475 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 698969003476 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 698969003477 active site 698969003478 substrate binding site [chemical binding]; other site 698969003479 coenzyme B12 binding site [chemical binding]; other site 698969003480 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 698969003481 B12 binding site [chemical binding]; other site 698969003482 cobalt ligand [ion binding]; other site 698969003483 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 698969003484 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 698969003485 heterodimer interface [polypeptide binding]; other site 698969003486 substrate interaction site [chemical binding]; other site 698969003487 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 698969003488 Uncharacterized conserved protein [Function unknown]; Region: COG0398 698969003489 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 698969003490 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698969003491 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 698969003492 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 698969003493 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 698969003494 ferrochelatase; Reviewed; Region: hemH; PRK00035 698969003495 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 698969003496 C-terminal domain interface [polypeptide binding]; other site 698969003497 active site 698969003498 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 698969003499 active site 698969003500 N-terminal domain interface [polypeptide binding]; other site 698969003501 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698969003502 NlpC/P60 family; Region: NLPC_P60; pfam00877 698969003503 aconitate hydratase; Validated; Region: PRK09277 698969003504 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698969003505 substrate binding site [chemical binding]; other site 698969003506 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698969003507 ligand binding site [chemical binding]; other site 698969003508 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 698969003509 substrate binding site [chemical binding]; other site 698969003510 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698969003511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698969003512 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 698969003513 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 698969003514 catalytic triad [active] 698969003515 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 698969003516 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 698969003517 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698969003518 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698969003519 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969003520 Walker A/P-loop; other site 698969003521 ATP binding site [chemical binding]; other site 698969003522 Q-loop/lid; other site 698969003523 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698969003524 ABC transporter signature motif; other site 698969003525 Walker B; other site 698969003526 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698969003527 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 698969003528 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 698969003529 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 698969003530 trimerization site [polypeptide binding]; other site 698969003531 active site 698969003532 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698969003533 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 698969003534 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698969003535 catalytic residue [active] 698969003536 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 698969003537 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 698969003538 Walker A/P-loop; other site 698969003539 ATP binding site [chemical binding]; other site 698969003540 Q-loop/lid; other site 698969003541 ABC transporter signature motif; other site 698969003542 Walker B; other site 698969003543 D-loop; other site 698969003544 H-loop/switch region; other site 698969003545 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 698969003546 FeS assembly protein SufD; Region: sufD; TIGR01981 698969003547 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 698969003548 FeS assembly protein SufB; Region: sufB; TIGR01980 698969003549 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698969003550 Predicted transcriptional regulator [Transcription]; Region: COG2345 698969003551 putative DNA binding site [nucleotide binding]; other site 698969003552 putative Zn2+ binding site [ion binding]; other site 698969003553 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698969003554 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698969003555 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698969003556 Walker A/P-loop; other site 698969003557 ATP binding site [chemical binding]; other site 698969003558 Q-loop/lid; other site 698969003559 ABC transporter signature motif; other site 698969003560 Walker B; other site 698969003561 D-loop; other site 698969003562 H-loop/switch region; other site 698969003563 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698969003564 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698969003565 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 698969003566 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 698969003567 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 698969003568 UbiA prenyltransferase family; Region: UbiA; pfam01040 698969003569 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 698969003570 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 698969003571 TPP-binding site [chemical binding]; other site 698969003572 dimer interface [polypeptide binding]; other site 698969003573 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698969003574 PYR/PP interface [polypeptide binding]; other site 698969003575 dimer interface [polypeptide binding]; other site 698969003576 TPP binding site [chemical binding]; other site 698969003577 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698969003578 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 698969003579 putative active site [active] 698969003580 transaldolase; Provisional; Region: PRK03903 698969003581 catalytic residue [active] 698969003582 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 698969003583 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 698969003584 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 698969003585 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 698969003586 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 698969003587 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698969003588 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 698969003589 putative active site [active] 698969003590 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 698969003591 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 698969003592 triosephosphate isomerase; Provisional; Region: PRK14567 698969003593 substrate binding site [chemical binding]; other site 698969003594 dimer interface [polypeptide binding]; other site 698969003595 catalytic triad [active] 698969003596 Phosphoglycerate kinase; Region: PGK; pfam00162 698969003597 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 698969003598 substrate binding site [chemical binding]; other site 698969003599 hinge regions; other site 698969003600 ADP binding site [chemical binding]; other site 698969003601 catalytic site [active] 698969003602 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 698969003603 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 698969003604 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698969003605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 698969003606 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 698969003607 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 698969003608 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 698969003609 phosphate binding site [ion binding]; other site 698969003610 putative substrate binding pocket [chemical binding]; other site 698969003611 dimer interface [polypeptide binding]; other site 698969003612 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 698969003613 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 698969003614 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 698969003615 GIY-YIG motif/motif A; other site 698969003616 active site 698969003617 catalytic site [active] 698969003618 putative DNA binding site [nucleotide binding]; other site 698969003619 metal binding site [ion binding]; metal-binding site 698969003620 UvrB/uvrC motif; Region: UVR; pfam02151 698969003621 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 698969003622 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698969003623 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 698969003624 homopentamer interface [polypeptide binding]; other site 698969003625 active site 698969003626 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 698969003627 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 698969003628 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 698969003629 dimerization interface [polypeptide binding]; other site 698969003630 active site 698969003631 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 698969003632 Lumazine binding domain; Region: Lum_binding; pfam00677 698969003633 Lumazine binding domain; Region: Lum_binding; pfam00677 698969003634 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 698969003635 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 698969003636 catalytic motif [active] 698969003637 Zn binding site [ion binding]; other site 698969003638 RibD C-terminal domain; Region: RibD_C; pfam01872 698969003639 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 698969003640 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 698969003641 substrate binding site [chemical binding]; other site 698969003642 hexamer interface [polypeptide binding]; other site 698969003643 metal binding site [ion binding]; metal-binding site 698969003644 16S rRNA methyltransferase B; Provisional; Region: PRK14902 698969003645 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 698969003646 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698969003647 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 698969003648 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 698969003649 putative active site [active] 698969003650 substrate binding site [chemical binding]; other site 698969003651 putative cosubstrate binding site; other site 698969003652 catalytic site [active] 698969003653 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 698969003654 substrate binding site [chemical binding]; other site 698969003655 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698969003656 active site 698969003657 catalytic residues [active] 698969003658 metal binding site [ion binding]; metal-binding site 698969003659 primosome assembly protein PriA; Provisional; Region: PRK14873 698969003660 S-adenosylmethionine synthetase; Validated; Region: PRK05250 698969003661 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 698969003662 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 698969003663 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 698969003664 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 698969003665 Flavoprotein; Region: Flavoprotein; pfam02441 698969003666 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 698969003667 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 698969003668 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 698969003669 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 698969003670 catalytic site [active] 698969003671 G-X2-G-X-G-K; other site 698969003672 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 698969003673 active site 698969003674 dimer interface [polypeptide binding]; other site 698969003675 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 698969003676 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698969003677 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698969003678 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 698969003679 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698969003680 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698969003681 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 698969003682 IMP binding site; other site 698969003683 dimer interface [polypeptide binding]; other site 698969003684 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 698969003685 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 698969003686 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 698969003687 catalytic site [active] 698969003688 subunit interface [polypeptide binding]; other site 698969003689 dihydroorotase; Validated; Region: pyrC; PRK09357 698969003690 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698969003691 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 698969003692 active site 698969003693 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 698969003694 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698969003695 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698969003696 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 698969003697 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698969003698 active site 698969003699 hydrophobic ligand binding site; other site 698969003700 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698969003701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698969003702 TIGR01777 family protein; Region: yfcH 698969003703 NAD(P) binding site [chemical binding]; other site 698969003704 active site 698969003705 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 698969003706 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 698969003707 elongation factor P; Validated; Region: PRK00529 698969003708 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 698969003709 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 698969003710 RNA binding site [nucleotide binding]; other site 698969003711 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 698969003712 RNA binding site [nucleotide binding]; other site 698969003713 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698969003714 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698969003715 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698969003716 active site 698969003717 Dehydroquinase class II; Region: DHquinase_II; pfam01220 698969003718 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 698969003719 trimer interface [polypeptide binding]; other site 698969003720 active site 698969003721 dimer interface [polypeptide binding]; other site 698969003722 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 698969003723 active site 698969003724 dimer interface [polypeptide binding]; other site 698969003725 metal binding site [ion binding]; metal-binding site 698969003726 shikimate kinase; Reviewed; Region: aroK; PRK00131 698969003727 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 698969003728 ADP binding site [chemical binding]; other site 698969003729 magnesium binding site [ion binding]; other site 698969003730 putative shikimate binding site; other site 698969003731 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 698969003732 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 698969003733 Tetramer interface [polypeptide binding]; other site 698969003734 active site 698969003735 FMN-binding site [chemical binding]; other site 698969003736 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 698969003737 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698969003738 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698969003739 shikimate binding site; other site 698969003740 NAD(P) binding site [chemical binding]; other site 698969003741 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 698969003742 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 698969003743 dimerization interface [polypeptide binding]; other site 698969003744 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 698969003745 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 698969003746 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 698969003747 motif 1; other site 698969003748 active site 698969003749 motif 2; other site 698969003750 motif 3; other site 698969003751 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698969003752 DHHA1 domain; Region: DHHA1; pfam02272 698969003753 recombination factor protein RarA; Reviewed; Region: PRK13342 698969003754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698969003755 Walker A motif; other site 698969003756 ATP binding site [chemical binding]; other site 698969003757 Walker B motif; other site 698969003758 arginine finger; other site 698969003759 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 698969003760 Phosphotransferase enzyme family; Region: APH; pfam01636 698969003761 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698969003762 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 698969003763 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 698969003764 dimer interface [polypeptide binding]; other site 698969003765 anticodon binding site; other site 698969003766 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 698969003767 homodimer interface [polypeptide binding]; other site 698969003768 motif 1; other site 698969003769 active site 698969003770 motif 2; other site 698969003771 GAD domain; Region: GAD; pfam02938 698969003772 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698969003773 active site 698969003774 motif 3; other site 698969003775 Predicted metalloprotease [General function prediction only]; Region: COG2321 698969003776 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 698969003777 potential frameshift: common BLAST hit: gi|62390520|ref|YP_225922.1| SNF2 family DNA/RNA helicase 698969003778 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698969003779 ATP binding site [chemical binding]; other site 698969003780 putative Mg++ binding site [ion binding]; other site 698969003781 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698969003782 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 698969003783 nucleotide binding region [chemical binding]; other site 698969003784 ATP-binding site [chemical binding]; other site 698969003785 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 698969003786 Predicted membrane protein [Function unknown]; Region: COG1511 698969003787 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698969003788 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698969003789 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698969003790 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698969003791 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698969003792 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969003793 Q-loop/lid; other site 698969003794 ABC transporter signature motif; other site 698969003795 Walker B; other site 698969003796 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698969003797 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698969003798 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698969003799 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698969003800 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698969003801 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 698969003802 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 698969003803 dimer interface [polypeptide binding]; other site 698969003804 motif 1; other site 698969003805 active site 698969003806 motif 2; other site 698969003807 motif 3; other site 698969003808 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 698969003809 anticodon binding site; other site 698969003810 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698969003811 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 698969003812 dimer interface [polypeptide binding]; other site 698969003813 catalytic triad [active] 698969003814 peroxidatic and resolving cysteines [active] 698969003815 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698969003816 active site 698969003817 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698969003818 MULE transposase domain; Region: MULE; pfam10551 698969003819 potential frameshift: common BLAST hit: gi|38233440|ref|NP_939207.1| transposase 698969003820 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698969003821 potential frameshift: common BLAST hit: gi|38233854|ref|NP_939621.1| transposase 698969003822 HTH-like domain; Region: HTH_21; pfam13276 698969003823 Integrase core domain; Region: rve; pfam00665 698969003824 Integrase core domain; Region: rve_2; pfam13333 698969003825 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698969003826 MULE transposase domain; Region: MULE; pfam10551 698969003827 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698969003828 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698969003829 Zn2+ binding site [ion binding]; other site 698969003830 Mg2+ binding site [ion binding]; other site 698969003831 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698969003832 synthetase active site [active] 698969003833 NTP binding site [chemical binding]; other site 698969003834 metal binding site [ion binding]; metal-binding site 698969003835 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 698969003836 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 698969003837 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698969003838 active site 698969003839 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 698969003840 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698969003841 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 698969003842 Protein export membrane protein; Region: SecD_SecF; cl14618 698969003843 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 698969003844 Protein export membrane protein; Region: SecD_SecF; cl14618 698969003845 Preprotein translocase subunit; Region: YajC; pfam02699 698969003846 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 698969003847 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698969003848 Walker A motif; other site 698969003849 ATP binding site [chemical binding]; other site 698969003850 Walker B motif; other site 698969003851 arginine finger; other site 698969003852 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 698969003853 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 698969003854 RuvA N terminal domain; Region: RuvA_N; pfam01330 698969003855 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 698969003856 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 698969003857 active site 698969003858 putative DNA-binding cleft [nucleotide binding]; other site 698969003859 dimer interface [polypeptide binding]; other site 698969003860 hypothetical protein; Validated; Region: PRK00110 698969003861 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 698969003862 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 698969003863 active site 698969003864 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 698969003865 catalytic triad [active] 698969003866 dimer interface [polypeptide binding]; other site 698969003867 HTH-like domain; Region: HTH_21; pfam13276 698969003868 Integrase core domain; Region: rve; pfam00665 698969003869 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698969003870 Helix-turn-helix domain; Region: HTH_38; pfam13936 698969003871 Integrase core domain; Region: rve; pfam00665 698969003872 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 698969003873 Nitronate monooxygenase; Region: NMO; pfam03060 698969003874 FMN binding site [chemical binding]; other site 698969003875 substrate binding site [chemical binding]; other site 698969003876 putative catalytic residue [active] 698969003877 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 698969003878 Replicase family; Region: Replicase; pfam03090 698969003879 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 698969003880 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698969003881 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698969003882 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698969003883 catalytic residues [active] 698969003884 catalytic nucleophile [active] 698969003885 Presynaptic Site I dimer interface [polypeptide binding]; other site 698969003886 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698969003887 Synaptic Flat tetramer interface [polypeptide binding]; other site 698969003888 Synaptic Site I dimer interface [polypeptide binding]; other site 698969003889 DNA binding site [nucleotide binding] 698969003890 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698969003891 MULE transposase domain; Region: MULE; pfam10551 698969003892 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698969003893 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698969003894 6-carboxyhexanoate--CoA ligase; Region: BioW; pfam03744 698969003895 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 698969003896 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698969003897 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698969003898 catalytic residue [active] 698969003899 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698969003900 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698969003901 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 698969003902 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 698969003903 putative acyl-acceptor binding pocket; other site 698969003904 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698969003905 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 698969003906 nucleotide binding site/active site [active] 698969003907 HIT family signature motif; other site 698969003908 catalytic residue [active] 698969003909 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 698969003910 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698969003911 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 698969003912 active site 698969003913 dimer interface [polypeptide binding]; other site 698969003914 motif 1; other site 698969003915 motif 2; other site 698969003916 motif 3; other site 698969003917 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 698969003918 anticodon binding site; other site 698969003919 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 698969003920 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 698969003921 CopC domain; Region: CopC; cl01012 698969003922 hypothetical protein; Provisional; Region: PRK14059 698969003923 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 698969003924 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 698969003925 SelR domain; Region: SelR; pfam01641 698969003926 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 698969003927 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 698969003928 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 698969003929 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 698969003930 catalytic site [active] 698969003931 putative active site [active] 698969003932 putative substrate binding site [chemical binding]; other site 698969003933 HRDC domain; Region: HRDC; pfam00570 698969003934 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 698969003935 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 698969003936 TPP-binding site; other site 698969003937 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698969003938 PYR/PP interface [polypeptide binding]; other site 698969003939 dimer interface [polypeptide binding]; other site 698969003940 TPP binding site [chemical binding]; other site 698969003941 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698969003942 TRAM domain; Region: TRAM; cl01282 698969003943 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 698969003944 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 698969003945 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698969003946 trimer interface [polypeptide binding]; other site 698969003947 active site 698969003948 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 698969003949 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 698969003950 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 698969003951 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698969003952 active site 698969003953 dimerization interface [polypeptide binding]; other site 698969003954 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698969003955 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698969003956 nucleotide binding site [chemical binding]; other site 698969003957 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698969003958 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698969003959 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698969003960 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698969003961 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698969003962 DNA binding residues [nucleotide binding] 698969003963 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698969003964 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698969003965 ATP binding site [chemical binding]; other site 698969003966 putative Mg++ binding site [ion binding]; other site 698969003967 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 698969003968 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 698969003969 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 698969003970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698969003971 S-adenosylmethionine binding site [chemical binding]; other site 698969003972 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 698969003973 putative active site [active] 698969003974 dimerization interface [polypeptide binding]; other site 698969003975 putative tRNAtyr binding site [nucleotide binding]; other site 698969003976 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698969003977 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698969003978 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698969003979 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698969003980 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698969003981 DNA binding residues [nucleotide binding] 698969003982 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698969003983 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698969003984 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698969003985 FeoA domain; Region: FeoA; cl00838 698969003986 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 698969003987 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 698969003988 NAD binding site [chemical binding]; other site 698969003989 homodimer interface [polypeptide binding]; other site 698969003990 active site 698969003991 substrate binding site [chemical binding]; other site 698969003992 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 698969003993 PAC2 family; Region: PAC2; pfam09754 698969003994 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698969003995 ATP binding site [chemical binding]; other site 698969003996 putative Mg++ binding site [ion binding]; other site 698969003997 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698969003998 nucleotide binding region [chemical binding]; other site 698969003999 ATP-binding site [chemical binding]; other site 698969004000 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 698969004001 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 698969004002 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 698969004003 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698969004004 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 698969004005 dimer interface [polypeptide binding]; other site 698969004006 decamer (pentamer of dimers) interface [polypeptide binding]; other site 698969004007 catalytic triad [active] 698969004008 peroxidatic and resolving cysteines [active] 698969004009 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698969004010 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 698969004011 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 698969004012 dimerization interface [polypeptide binding]; other site 698969004013 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 698969004014 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698969004015 ATP binding site [chemical binding]; other site 698969004016 putative Mg++ binding site [ion binding]; other site 698969004017 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698969004018 nucleotide binding region [chemical binding]; other site 698969004019 ATP-binding site [chemical binding]; other site 698969004020 Helicase associated domain (HA2); Region: HA2; pfam04408 698969004021 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 698969004022 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 698969004023 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 698969004024 ATP cone domain; Region: ATP-cone; pfam03477 698969004025 LexA repressor; Validated; Region: PRK00215 698969004026 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 698969004027 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698969004028 Catalytic site [active] 698969004029 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698969004030 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 698969004031 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698969004032 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 698969004033 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 698969004034 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 698969004035 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 698969004036 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698969004037 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698969004038 DNA-binding site [nucleotide binding]; DNA binding site 698969004039 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698969004040 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 698969004041 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 698969004042 putative substrate binding site [chemical binding]; other site 698969004043 putative ATP binding site [chemical binding]; other site 698969004044 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698969004045 dimerization domain swap beta strand [polypeptide binding]; other site 698969004046 regulatory protein interface [polypeptide binding]; other site 698969004047 active site 698969004048 regulatory phosphorylation site [posttranslational modification]; other site 698969004049 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 698969004050 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698969004051 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 698969004052 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698969004053 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 698969004054 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 698969004055 GTPases [General function prediction only]; Region: HflX; COG2262 698969004056 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 698969004057 HflX GTPase family; Region: HflX; cd01878 698969004058 G1 box; other site 698969004059 GTP/Mg2+ binding site [chemical binding]; other site 698969004060 Switch I region; other site 698969004061 G2 box; other site 698969004062 G3 box; other site 698969004063 Switch II region; other site 698969004064 G4 box; other site 698969004065 G5 box; other site 698969004066 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 698969004067 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698969004068 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698969004069 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 698969004070 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 698969004071 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698969004072 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698969004073 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698969004074 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698969004075 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 698969004076 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 698969004077 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698969004078 FeS/SAM binding site; other site 698969004079 recombination regulator RecX; Reviewed; Region: recX; PRK00117 698969004080 recombinase A; Provisional; Region: recA; PRK09354 698969004081 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 698969004082 hexamer interface [polypeptide binding]; other site 698969004083 Walker A motif; other site 698969004084 ATP binding site [chemical binding]; other site 698969004085 Walker B motif; other site 698969004086 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 698969004087 BioY family; Region: BioY; pfam02632 698969004088 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698969004089 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698969004090 Walker A/P-loop; other site 698969004091 ATP binding site [chemical binding]; other site 698969004092 Q-loop/lid; other site 698969004093 ABC transporter signature motif; other site 698969004094 Walker B; other site 698969004095 D-loop; other site 698969004096 H-loop/switch region; other site 698969004097 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698969004098 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698969004099 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698969004100 sequence-specific DNA binding site [nucleotide binding]; other site 698969004101 salt bridge; other site 698969004102 Competence-damaged protein; Region: CinA; pfam02464 698969004103 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698969004104 YCII-related domain; Region: YCII; cl00999 698969004105 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 698969004106 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 698969004107 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698969004108 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 698969004109 TIGR03085 family protein; Region: TIGR03085 698969004110 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 698969004111 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698969004112 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 698969004113 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 698969004114 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698969004115 dimer interface [polypeptide binding]; other site 698969004116 active site 698969004117 catalytic residue [active] 698969004118 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 698969004119 dihydrodipicolinate reductase; Provisional; Region: PRK00048 698969004120 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 698969004121 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 698969004122 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 698969004123 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 698969004124 oligomer interface [polypeptide binding]; other site 698969004125 RNA binding site [nucleotide binding]; other site 698969004126 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 698969004127 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 698969004128 RNase E interface [polypeptide binding]; other site 698969004129 trimer interface [polypeptide binding]; other site 698969004130 active site 698969004131 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 698969004132 putative nucleic acid binding region [nucleotide binding]; other site 698969004133 G-X-X-G motif; other site 698969004134 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 698969004135 RNA binding site [nucleotide binding]; other site 698969004136 domain interface; other site 698969004137 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 698969004138 16S/18S rRNA binding site [nucleotide binding]; other site 698969004139 S13e-L30e interaction site [polypeptide binding]; other site 698969004140 25S rRNA binding site [nucleotide binding]; other site 698969004141 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 698969004142 active site 698969004143 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 698969004144 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 698969004145 active site 698969004146 Riboflavin kinase; Region: Flavokinase; smart00904 698969004147 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 698969004148 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 698969004149 RNA binding site [nucleotide binding]; other site 698969004150 active site 698969004151 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 698969004152 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 698969004153 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 698969004154 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698969004155 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698969004156 active site 698969004157 metal binding site [ion binding]; metal-binding site 698969004158 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698969004159 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 698969004160 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 698969004161 DHH family; Region: DHH; pfam01368 698969004162 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 698969004163 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698969004164 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698969004165 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 698969004166 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 698969004167 G1 box; other site 698969004168 putative GEF interaction site [polypeptide binding]; other site 698969004169 GTP/Mg2+ binding site [chemical binding]; other site 698969004170 Switch I region; other site 698969004171 G2 box; other site 698969004172 G3 box; other site 698969004173 Switch II region; other site 698969004174 G4 box; other site 698969004175 G5 box; other site 698969004176 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 698969004177 Translation-initiation factor 2; Region: IF-2; pfam11987 698969004178 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 698969004179 Protein of unknown function (DUF448); Region: DUF448; pfam04296 698969004180 putative RNA binding cleft [nucleotide binding]; other site 698969004181 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 698969004182 NusA N-terminal domain; Region: NusA_N; pfam08529 698969004183 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 698969004184 RNA binding site [nucleotide binding]; other site 698969004185 homodimer interface [polypeptide binding]; other site 698969004186 NusA-like KH domain; Region: KH_5; pfam13184 698969004187 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 698969004188 G-X-X-G motif; other site 698969004189 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 698969004190 Sm and related proteins; Region: Sm_like; cl00259 698969004191 prolyl-tRNA synthetase; Provisional; Region: PRK09194 698969004192 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 698969004193 dimer interface [polypeptide binding]; other site 698969004194 motif 1; other site 698969004195 active site 698969004196 motif 2; other site 698969004197 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 698969004198 putative deacylase active site [active] 698969004199 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698969004200 active site 698969004201 motif 3; other site 698969004202 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 698969004203 anticodon binding site; other site 698969004204 hypothetical protein; Validated; Region: PRK02101 698969004205 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 698969004206 active site 698969004207 SAM binding site [chemical binding]; other site 698969004208 homodimer interface [polypeptide binding]; other site 698969004209 Uncharacterized conserved protein [Function unknown]; Region: COG0397 698969004210 hypothetical protein; Validated; Region: PRK00029 698969004211 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698969004212 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 698969004213 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 698969004214 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 698969004215 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 698969004216 DNA binding site [nucleotide binding] 698969004217 active site 698969004218 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 698969004219 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 698969004220 catalytic triad [active] 698969004221 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 698969004222 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 698969004223 Walker A motif; other site 698969004224 homodimer interface [polypeptide binding]; other site 698969004225 ATP binding site [chemical binding]; other site 698969004226 hydroxycobalamin binding site [chemical binding]; other site 698969004227 Walker B motif; other site 698969004228 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 698969004229 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 698969004230 metal ion-dependent adhesion site (MIDAS); other site 698969004231 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 698969004232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698969004233 Walker A motif; other site 698969004234 ATP binding site [chemical binding]; other site 698969004235 Walker B motif; other site 698969004236 arginine finger; other site 698969004237 malate:quinone oxidoreductase; Validated; Region: PRK05257 698969004238 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 698969004239 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698969004240 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698969004241 mycothione reductase; Region: mycothione_red; TIGR03452 698969004242 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698969004243 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698969004244 cobyric acid synthase; Provisional; Region: PRK00784 698969004245 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 698969004246 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698969004247 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698969004248 catalytic triad [active] 698969004249 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698969004250 active site 698969004251 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 698969004252 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698969004253 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 698969004254 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698969004255 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698969004256 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 698969004257 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698969004258 active site 698969004259 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 698969004260 protein binding site [polypeptide binding]; other site 698969004261 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 698969004262 putative substrate binding region [chemical binding]; other site 698969004263 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 698969004264 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 698969004265 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 698969004266 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 698969004267 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 698969004268 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 698969004269 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698969004270 FeS/SAM binding site; other site 698969004271 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 698969004272 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 698969004273 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 698969004274 ribosome recycling factor; Reviewed; Region: frr; PRK00083 698969004275 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 698969004276 hinge region; other site 698969004277 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 698969004278 putative nucleotide binding site [chemical binding]; other site 698969004279 uridine monophosphate binding site [chemical binding]; other site 698969004280 homohexameric interface [polypeptide binding]; other site 698969004281 elongation factor Ts; Provisional; Region: tsf; PRK09377 698969004282 UBA/TS-N domain; Region: UBA; pfam00627 698969004283 Elongation factor TS; Region: EF_TS; pfam00889 698969004284 Elongation factor TS; Region: EF_TS; pfam00889 698969004285 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 698969004286 rRNA interaction site [nucleotide binding]; other site 698969004287 S8 interaction site; other site 698969004288 putative laminin-1 binding site; other site 698969004289 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698969004290 Peptidase family M23; Region: Peptidase_M23; pfam01551 698969004291 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698969004292 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 698969004293 active site 698969004294 DNA binding site [nucleotide binding] 698969004295 Int/Topo IB signature motif; other site 698969004296 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 698969004297 DNA protecting protein DprA; Region: dprA; TIGR00732 698969004298 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 698969004299 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 698969004300 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698969004301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698969004302 Walker A motif; other site 698969004303 ATP binding site [chemical binding]; other site 698969004304 Walker B motif; other site 698969004305 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 698969004306 hypothetical protein; Reviewed; Region: PRK12497 698969004307 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 698969004308 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 698969004309 RNA/DNA hybrid binding site [nucleotide binding]; other site 698969004310 active site 698969004311 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 698969004312 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698969004313 Catalytic site [active] 698969004314 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698969004315 Htaa; Region: HtaA; pfam04213 698969004316 Htaa; Region: HtaA; pfam04213 698969004317 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 698969004318 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 698969004319 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 698969004320 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 698969004321 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698969004322 RNA binding site [nucleotide binding]; other site 698969004323 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 698969004324 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 698969004325 RimM N-terminal domain; Region: RimM; pfam01782 698969004326 PRC-barrel domain; Region: PRC; pfam05239 698969004327 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 698969004328 signal recognition particle protein; Provisional; Region: PRK10867 698969004329 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 698969004330 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 698969004331 P loop; other site 698969004332 GTP binding site [chemical binding]; other site 698969004333 Signal peptide binding domain; Region: SRP_SPB; pfam02978 698969004334 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 698969004335 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698969004336 metal binding triad; other site 698969004337 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698969004338 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 698969004339 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 698969004340 Nitrogen regulatory protein P-II; Region: P-II; smart00938 698969004341 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 698969004342 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 698969004343 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 698969004344 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698969004345 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 698969004346 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698969004347 Walker A/P-loop; other site 698969004348 ATP binding site [chemical binding]; other site 698969004349 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 698969004350 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698969004351 ABC transporter signature motif; other site 698969004352 Walker B; other site 698969004353 D-loop; other site 698969004354 H-loop/switch region; other site 698969004355 Acylphosphatase; Region: Acylphosphatase; cl00551 698969004356 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698969004357 amino acid carrier protein; Region: agcS; TIGR00835 698969004358 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 698969004359 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 698969004360 DNA binding site [nucleotide binding] 698969004361 catalytic residue [active] 698969004362 H2TH interface [polypeptide binding]; other site 698969004363 putative catalytic residues [active] 698969004364 turnover-facilitating residue; other site 698969004365 intercalation triad [nucleotide binding]; other site 698969004366 8OG recognition residue [nucleotide binding]; other site 698969004367 putative reading head residues; other site 698969004368 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698969004369 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698969004370 ribonuclease III; Reviewed; Region: rnc; PRK00102 698969004371 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 698969004372 dimerization interface [polypeptide binding]; other site 698969004373 active site 698969004374 metal binding site [ion binding]; metal-binding site 698969004375 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 698969004376 dsRNA binding site [nucleotide binding]; other site 698969004377 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 698969004378 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698969004379 glutamate dehydrogenase; Provisional; Region: PRK09414 698969004380 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 698969004381 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 698969004382 NAD(P) binding site [chemical binding]; other site 698969004383 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 698969004384 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698969004385 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698969004386 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 698969004387 metal binding site [ion binding]; metal-binding site 698969004388 putative dimer interface [polypeptide binding]; other site 698969004389 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 698969004390 homodimer interface [polypeptide binding]; other site 698969004391 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 698969004392 active site pocket [active] 698969004393 pyruvate kinase; Provisional; Region: PRK06247 698969004394 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 698969004395 domain interfaces; other site 698969004396 active site 698969004397 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 698969004398 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698969004399 active site 698969004400 ribulose/triose binding site [chemical binding]; other site 698969004401 phosphate binding site [ion binding]; other site 698969004402 substrate (anthranilate) binding pocket [chemical binding]; other site 698969004403 product (indole) binding pocket [chemical binding]; other site 698969004404 trp region conserved hypothetical membrane protein; Region: trp_oprn_chp; TIGR02234 698969004405 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 698969004406 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 698969004407 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698969004408 substrate binding site [chemical binding]; other site 698969004409 glutamase interaction surface [polypeptide binding]; other site 698969004410 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698969004411 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698969004412 active site 698969004413 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 698969004414 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698969004415 catalytic residues [active] 698969004416 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 698969004417 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 698969004418 putative active site [active] 698969004419 oxyanion strand; other site 698969004420 catalytic triad [active] 698969004421 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698969004422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969004423 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 698969004424 putative active site pocket [active] 698969004425 4-fold oligomerization interface [polypeptide binding]; other site 698969004426 metal binding residues [ion binding]; metal-binding site 698969004427 3-fold/trimer interface [polypeptide binding]; other site 698969004428 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 698969004429 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698969004430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698969004431 homodimer interface [polypeptide binding]; other site 698969004432 catalytic residue [active] 698969004433 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 698969004434 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 698969004435 NAD binding site [chemical binding]; other site 698969004436 dimerization interface [polypeptide binding]; other site 698969004437 product binding site; other site 698969004438 substrate binding site [chemical binding]; other site 698969004439 zinc binding site [ion binding]; other site 698969004440 catalytic residues [active] 698969004441 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 698969004442 tetracycline repressor protein TetR; Provisional; Region: PRK13756 698969004443 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698969004444 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 698969004445 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 698969004446 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 698969004447 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 698969004448 active site 698969004449 catalytic site [active] 698969004450 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 698969004451 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 698969004452 active site 698969004453 catalytic site [active] 698969004454 substrate binding site [chemical binding]; other site 698969004455 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698969004456 synthetase active site [active] 698969004457 NTP binding site [chemical binding]; other site 698969004458 metal binding site [ion binding]; metal-binding site 698969004459 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698969004460 RNA binding surface [nucleotide binding]; other site 698969004461 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 698969004462 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 698969004463 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 698969004464 threonine dehydratase; Validated; Region: PRK08639 698969004465 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698969004466 tetramer interface [polypeptide binding]; other site 698969004467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698969004468 catalytic residue [active] 698969004469 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 698969004470 putative Ile/Val binding site [chemical binding]; other site 698969004471 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 698969004472 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 698969004473 active site 698969004474 PHP Thumb interface [polypeptide binding]; other site 698969004475 metal binding site [ion binding]; metal-binding site 698969004476 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698969004477 generic binding surface II; other site 698969004478 generic binding surface I; other site 698969004479 Predicted permeases [General function prediction only]; Region: RarD; COG2962 698969004480 EamA-like transporter family; Region: EamA; cl17759 698969004481 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698969004482 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698969004483 RNA binding surface [nucleotide binding]; other site 698969004484 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698969004485 active site 698969004486 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 698969004487 lipoprotein signal peptidase; Provisional; Region: PRK14787 698969004488 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698969004489 active site 698969004490 homotetramer interface [polypeptide binding]; other site 698969004491 homodimer interface [polypeptide binding]; other site 698969004492 DNA polymerase IV; Provisional; Region: PRK03348 698969004493 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 698969004494 active site 698969004495 DNA binding site [nucleotide binding] 698969004496 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 698969004497 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698969004498 HIGH motif; other site 698969004499 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698969004500 active site 698969004501 KMSKS motif; other site 698969004502 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 698969004503 tRNA binding surface [nucleotide binding]; other site 698969004504 anticodon binding site; other site 698969004505 DivIVA domain; Region: DivI1A_domain; TIGR03544 698969004506 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698969004507 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 698969004508 YGGT family; Region: YGGT; cl00508 698969004509 Protein of unknown function (DUF552); Region: DUF552; cl00775 698969004510 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 698969004511 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 698969004512 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 698969004513 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 698969004514 nucleotide binding site [chemical binding]; other site 698969004515 SulA interaction site; other site 698969004516 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 698969004517 Cell division protein FtsQ; Region: FtsQ; pfam03799 698969004518 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 698969004519 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698969004520 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698969004521 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698969004522 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 698969004523 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 698969004524 active site 698969004525 homodimer interface [polypeptide binding]; other site 698969004526 cell division protein FtsW; Region: ftsW; TIGR02614 698969004527 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 698969004528 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698969004529 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698969004530 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 698969004531 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 698969004532 Mg++ binding site [ion binding]; other site 698969004533 putative catalytic motif [active] 698969004534 putative substrate binding site [chemical binding]; other site 698969004535 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 698969004536 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698969004537 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698969004538 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698969004539 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 698969004540 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698969004541 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698969004542 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698969004543 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698969004544 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698969004545 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698969004546 MraW methylase family; Region: Methyltransf_5; cl17771 698969004547 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 698969004548 cell division protein MraZ; Reviewed; Region: PRK00326 698969004549 MraZ protein; Region: MraZ; pfam02381 698969004550 MraZ protein; Region: MraZ; pfam02381 698969004551 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 698969004552 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698969004553 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698969004554 Coenzyme A binding pocket [chemical binding]; other site 698969004555 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 698969004556 FAD binding site [chemical binding]; other site 698969004557 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698969004558 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698969004559 substrate binding pocket [chemical binding]; other site 698969004560 chain length determination region; other site 698969004561 substrate-Mg2+ binding site; other site 698969004562 catalytic residues [active] 698969004563 aspartate-rich region 1; other site 698969004564 active site lid residues [active] 698969004565 aspartate-rich region 2; other site 698969004566 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698969004567 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698969004568 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698969004569 active site 698969004570 ATP binding site [chemical binding]; other site 698969004571 substrate binding site [chemical binding]; other site 698969004572 activation loop (A-loop); other site 698969004573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698969004574 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698969004575 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698969004576 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698969004577 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698969004578 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 698969004579 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698969004580 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698969004581 putative acyl-acceptor binding pocket; other site 698969004582 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698969004583 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698969004584 nucleotide binding site [chemical binding]; other site 698969004585 Tesmin/TSO1-like CXC domain; Region: CXC; pfam03638 698969004586 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698969004587 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698969004588 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698969004589 NlpC/P60 family; Region: NLPC_P60; pfam00877 698969004590 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698969004591 NlpC/P60 family; Region: NLPC_P60; pfam00877 698969004592 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 698969004593 heme bH binding site [chemical binding]; other site 698969004594 intrachain domain interface; other site 698969004595 heme bL binding site [chemical binding]; other site 698969004596 interchain domain interface [polypeptide binding]; other site 698969004597 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 698969004598 Qo binding site; other site 698969004599 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 698969004600 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698969004601 iron-sulfur cluster [ion binding]; other site 698969004602 [2Fe-2S] cluster binding site [ion binding]; other site 698969004603 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698969004604 Cytochrome c; Region: Cytochrom_C; pfam00034 698969004605 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698969004606 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 698969004607 Subunit I/III interface [polypeptide binding]; other site 698969004608 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 698969004609 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 698969004610 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 698969004611 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 698969004612 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 698969004613 active site 698969004614 dimer interface [polypeptide binding]; other site 698969004615 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 698969004616 Ligand Binding Site [chemical binding]; other site 698969004617 Molecular Tunnel; other site 698969004618 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 698969004619 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 698969004620 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 698969004621 homotrimer interface [polypeptide binding]; other site 698969004622 Walker A motif; other site 698969004623 GTP binding site [chemical binding]; other site 698969004624 Walker B motif; other site 698969004625 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 698969004626 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 698969004627 putative dimer interface [polypeptide binding]; other site 698969004628 active site pocket [active] 698969004629 putative cataytic base [active] 698969004630 cobalamin synthase; Reviewed; Region: cobS; PRK00235 698969004631 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 698969004632 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 698969004633 homodimer interface [polypeptide binding]; other site 698969004634 substrate-cofactor binding pocket; other site 698969004635 catalytic residue [active] 698969004636 multifunctional aminopeptidase A; Provisional; Region: PRK00913 698969004637 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 698969004638 interface (dimer of trimers) [polypeptide binding]; other site 698969004639 Substrate-binding/catalytic site; other site 698969004640 Zn-binding sites [ion binding]; other site 698969004641 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 698969004642 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698969004643 E3 interaction surface; other site 698969004644 lipoyl attachment site [posttranslational modification]; other site 698969004645 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698969004646 E3 interaction surface; other site 698969004647 lipoyl attachment site [posttranslational modification]; other site 698969004648 e3 binding domain; Region: E3_binding; pfam02817 698969004649 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698969004650 lipoate-protein ligase B; Provisional; Region: PRK14345 698969004651 lipoyl synthase; Provisional; Region: PRK05481 698969004652 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698969004653 FeS/SAM binding site; other site 698969004654 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 698969004655 RDD family; Region: RDD; pfam06271 698969004656 glutamine synthetase, type I; Region: GlnA; TIGR00653 698969004657 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698969004658 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698969004659 Predicted peptidase [General function prediction only]; Region: COG4099 698969004660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 698969004661 Predicted permease [General function prediction only]; Region: COG2056 698969004662 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 698969004663 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698969004664 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698969004665 DNA-binding site [nucleotide binding]; DNA binding site 698969004666 FCD domain; Region: FCD; pfam07729 698969004667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969004668 putative substrate translocation pore; other site 698969004669 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 698969004670 nudix motif; other site 698969004671 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 698969004672 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 698969004673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698969004674 catalytic residue [active] 698969004675 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 698969004676 heme binding pocket [chemical binding]; other site 698969004677 heme ligand [chemical binding]; other site 698969004678 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 698969004679 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698969004680 metal binding triad; other site 698969004681 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698969004682 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698969004683 metal binding triad; other site 698969004684 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698969004685 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 698969004686 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698969004687 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698969004688 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 698969004689 putative active site; other site 698969004690 putative metal binding residues [ion binding]; other site 698969004691 signature motif; other site 698969004692 putative triphosphate binding site [ion binding]; other site 698969004693 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 698969004694 galactokinase; Provisional; Region: PRK00555 698969004695 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698969004696 RNB domain; Region: RNB; pfam00773 698969004697 Predicted membrane protein [General function prediction only]; Region: COG4194 698969004698 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 698969004699 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 698969004700 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 698969004701 RNA/DNA hybrid binding site [nucleotide binding]; other site 698969004702 active site 698969004703 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698969004704 catalytic core [active] 698969004705 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 698969004706 Putative zinc ribbon domain; Region: DUF164; pfam02591 698969004707 Uncharacterized conserved protein [Function unknown]; Region: COG0327 698969004708 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698969004709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 698969004710 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698969004711 hypothetical protein; Provisional; Region: PRK07908 698969004712 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698969004713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698969004714 homodimer interface [polypeptide binding]; other site 698969004715 catalytic residue [active] 698969004716 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 698969004717 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698969004718 motif II; other site 698969004719 Low molecular weight phosphatase family; Region: LMWPc; cd00115 698969004720 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 698969004721 active site 698969004722 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 698969004723 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 698969004724 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 698969004725 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 698969004726 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 698969004727 dimer interface [polypeptide binding]; other site 698969004728 TPP-binding site [chemical binding]; other site 698969004729 Electron transfer DM13; Region: DM13; pfam10517 698969004730 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698969004731 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698969004732 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698969004733 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 698969004734 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698969004735 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698969004736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698969004737 active site 698969004738 motif I; other site 698969004739 motif II; other site 698969004740 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698969004741 motif II; other site 698969004742 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698969004743 Beta-lactamase; Region: Beta-lactamase; pfam00144 698969004744 Predicted membrane protein [Function unknown]; Region: COG2860 698969004745 UPF0126 domain; Region: UPF0126; pfam03458 698969004746 UPF0126 domain; Region: UPF0126; pfam03458 698969004747 DNA primase; Validated; Region: dnaG; PRK05667 698969004748 CHC2 zinc finger; Region: zf-CHC2; pfam01807 698969004749 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 698969004750 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 698969004751 active site 698969004752 metal binding site [ion binding]; metal-binding site 698969004753 interdomain interaction site; other site 698969004754 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 698969004755 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 698969004756 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 698969004757 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 698969004758 glutaminase active site [active] 698969004759 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698969004760 dimer interface [polypeptide binding]; other site 698969004761 active site 698969004762 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 698969004763 dimer interface [polypeptide binding]; other site 698969004764 active site 698969004765 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 698969004766 active site 698969004767 barstar interaction site; other site 698969004768 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 698969004769 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698969004770 Zn2+ binding site [ion binding]; other site 698969004771 Mg2+ binding site [ion binding]; other site 698969004772 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 698969004773 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698969004774 putative active site [active] 698969004775 Repair protein; Region: Repair_PSII; pfam04536 698969004776 glycyl-tRNA synthetase; Provisional; Region: PRK04173 698969004777 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698969004778 motif 1; other site 698969004779 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 698969004780 active site 698969004781 motif 2; other site 698969004782 motif 3; other site 698969004783 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 698969004784 anticodon binding site; other site 698969004785 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698969004786 dimerization interface [polypeptide binding]; other site 698969004787 putative DNA binding site [nucleotide binding]; other site 698969004788 putative Zn2+ binding site [ion binding]; other site 698969004789 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698969004790 metal binding site 2 [ion binding]; metal-binding site 698969004791 putative DNA binding helix; other site 698969004792 metal binding site 1 [ion binding]; metal-binding site 698969004793 dimer interface [polypeptide binding]; other site 698969004794 structural Zn2+ binding site [ion binding]; other site 698969004795 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 698969004796 diiron binding motif [ion binding]; other site 698969004797 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 698969004798 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698969004799 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 698969004800 catalytic residue [active] 698969004801 putative FPP diphosphate binding site; other site 698969004802 putative FPP binding hydrophobic cleft; other site 698969004803 dimer interface [polypeptide binding]; other site 698969004804 putative IPP diphosphate binding site; other site 698969004805 Recombination protein O N terminal; Region: RecO_N; pfam11967 698969004806 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 698969004807 Recombination protein O C terminal; Region: RecO_C; pfam02565 698969004808 GTPase Era; Reviewed; Region: era; PRK00089 698969004809 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 698969004810 G1 box; other site 698969004811 GTP/Mg2+ binding site [chemical binding]; other site 698969004812 Switch I region; other site 698969004813 G2 box; other site 698969004814 Switch II region; other site 698969004815 G3 box; other site 698969004816 G4 box; other site 698969004817 G5 box; other site 698969004818 KH domain; Region: KH_2; pfam07650 698969004819 pyridoxamine kinase; Validated; Region: PRK05756 698969004820 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 698969004821 dimer interface [polypeptide binding]; other site 698969004822 pyridoxal binding site [chemical binding]; other site 698969004823 ATP binding site [chemical binding]; other site 698969004824 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698969004825 Domain of unknown function DUF21; Region: DUF21; pfam01595 698969004826 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698969004827 Transporter associated domain; Region: CorC_HlyC; smart01091 698969004828 metal-binding heat shock protein; Provisional; Region: PRK00016 698969004829 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 698969004830 PhoH-like protein; Region: PhoH; pfam02562 698969004831 RNA methyltransferase, RsmE family; Region: TIGR00046 698969004832 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 698969004833 chaperone protein DnaJ; Provisional; Region: PRK14278 698969004834 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698969004835 HSP70 interaction site [polypeptide binding]; other site 698969004836 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698969004837 Zn binding sites [ion binding]; other site 698969004838 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698969004839 dimer interface [polypeptide binding]; other site 698969004840 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 698969004841 coproporphyrinogen III oxidase; Validated; Region: PRK05628 698969004842 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698969004843 FeS/SAM binding site; other site 698969004844 HemN C-terminal domain; Region: HemN_C; pfam06969 698969004845 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698969004846 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698969004847 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698969004848 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698969004849 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 698969004850 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 698969004851 acyl-activating enzyme (AAE) consensus motif; other site 698969004852 putative AMP binding site [chemical binding]; other site 698969004853 putative active site [active] 698969004854 putative CoA binding site [chemical binding]; other site 698969004855 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 698969004856 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 698969004857 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 698969004858 active site 698969004859 Zn binding site [ion binding]; other site 698969004860 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698969004861 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698969004862 substrate binding pocket [chemical binding]; other site 698969004863 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 698969004864 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 698969004865 active site 698969004866 metal binding site [ion binding]; metal-binding site 698969004867 nudix motif; other site 698969004868 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698969004869 active site 698969004870 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698969004871 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698969004872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969004873 Walker A/P-loop; other site 698969004874 ATP binding site [chemical binding]; other site 698969004875 Q-loop/lid; other site 698969004876 ABC transporter signature motif; other site 698969004877 Walker B; other site 698969004878 D-loop; other site 698969004879 H-loop/switch region; other site 698969004880 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 698969004881 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698969004882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698969004883 homodimer interface [polypeptide binding]; other site 698969004884 catalytic residue [active] 698969004885 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 698969004886 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698969004887 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 698969004888 BCCT family transporter; Region: BCCT; pfam02028 698969004889 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698969004890 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 698969004891 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698969004892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698969004893 dimer interface [polypeptide binding]; other site 698969004894 conserved gate region; other site 698969004895 putative PBP binding loops; other site 698969004896 ABC-ATPase subunit interface; other site 698969004897 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698969004898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698969004899 dimer interface [polypeptide binding]; other site 698969004900 conserved gate region; other site 698969004901 putative PBP binding loops; other site 698969004902 ABC-ATPase subunit interface; other site 698969004903 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698969004904 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698969004905 Walker A/P-loop; other site 698969004906 ATP binding site [chemical binding]; other site 698969004907 Q-loop/lid; other site 698969004908 ABC transporter signature motif; other site 698969004909 Walker B; other site 698969004910 D-loop; other site 698969004911 H-loop/switch region; other site 698969004912 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698969004913 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698969004914 Walker A/P-loop; other site 698969004915 ATP binding site [chemical binding]; other site 698969004916 Q-loop/lid; other site 698969004917 ABC transporter signature motif; other site 698969004918 Walker B; other site 698969004919 D-loop; other site 698969004920 H-loop/switch region; other site 698969004921 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698969004922 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 698969004923 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 698969004924 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698969004925 catalytic residue [active] 698969004926 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698969004927 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698969004928 nucleotide binding site [chemical binding]; other site 698969004929 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 698969004930 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698969004931 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698969004932 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 698969004933 active site residue [active] 698969004934 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 698969004935 putative homodimer interface [polypeptide binding]; other site 698969004936 putative homotetramer interface [polypeptide binding]; other site 698969004937 putative allosteric switch controlling residues; other site 698969004938 putative metal binding site [ion binding]; other site 698969004939 putative homodimer-homodimer interface [polypeptide binding]; other site 698969004940 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 698969004941 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698969004942 TrkA-N domain; Region: TrkA_N; pfam02254 698969004943 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 698969004944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969004945 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 698969004946 active site 698969004947 tetramer interface [polypeptide binding]; other site 698969004948 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698969004949 MULE transposase domain; Region: MULE; pfam10551 698969004950 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 698969004951 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698969004952 Mrr N-terminal domain; Region: Mrr_N; pfam14338 698969004953 Restriction endonuclease; Region: Mrr_cat; pfam04471 698969004954 Abi-like protein; Region: Abi_2; pfam07751 698969004955 GTP-binding protein LepA; Provisional; Region: PRK05433 698969004956 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 698969004957 G1 box; other site 698969004958 putative GEF interaction site [polypeptide binding]; other site 698969004959 GTP/Mg2+ binding site [chemical binding]; other site 698969004960 Switch I region; other site 698969004961 G2 box; other site 698969004962 G3 box; other site 698969004963 Switch II region; other site 698969004964 G4 box; other site 698969004965 G5 box; other site 698969004966 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 698969004967 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 698969004968 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 698969004969 PemK-like protein; Region: PemK; pfam02452 698969004970 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 698969004971 LysE type translocator; Region: LysE; cl00565 698969004972 hypothetical protein; Validated; Region: PRK05629 698969004973 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 698969004974 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 698969004975 Competence protein; Region: Competence; pfam03772 698969004976 comEA protein; Region: comE; TIGR01259 698969004977 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 698969004978 helix-hairpin-helix signature motif; other site 698969004979 EDD domain protein, DegV family; Region: DegV; TIGR00762 698969004980 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 698969004981 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698969004982 catalytic core [active] 698969004983 Oligomerisation domain; Region: Oligomerisation; cl00519 698969004984 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 698969004985 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 698969004986 active site 698969004987 (T/H)XGH motif; other site 698969004988 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 698969004989 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 698969004990 putative catalytic cysteine [active] 698969004991 gamma-glutamyl kinase; Provisional; Region: PRK05429 698969004992 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 698969004993 nucleotide binding site [chemical binding]; other site 698969004994 homotetrameric interface [polypeptide binding]; other site 698969004995 putative phosphate binding site [ion binding]; other site 698969004996 putative allosteric binding site; other site 698969004997 PUA domain; Region: PUA; pfam01472 698969004998 GTPase CgtA; Reviewed; Region: obgE; PRK12296 698969004999 GTP1/OBG; Region: GTP1_OBG; pfam01018 698969005000 Obg GTPase; Region: Obg; cd01898 698969005001 G1 box; other site 698969005002 GTP/Mg2+ binding site [chemical binding]; other site 698969005003 Switch I region; other site 698969005004 G2 box; other site 698969005005 G3 box; other site 698969005006 Switch II region; other site 698969005007 G4 box; other site 698969005008 G5 box; other site 698969005009 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 698969005010 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 698969005011 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 698969005012 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 698969005013 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698969005014 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 698969005015 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 698969005016 homodimer interface [polypeptide binding]; other site 698969005017 oligonucleotide binding site [chemical binding]; other site 698969005018 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 698969005019 active site 698969005020 multimer interface [polypeptide binding]; other site 698969005021 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 698969005022 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 698969005023 dimer interface [polypeptide binding]; other site 698969005024 active site 698969005025 CoA binding pocket [chemical binding]; other site 698969005026 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698969005027 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 698969005028 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698969005029 catalytic residue [active] 698969005030 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698969005031 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698969005032 active site 698969005033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969005034 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698969005035 Resolvase, N terminal domain; Region: Resolvase; pfam00239 698969005036 catalytic residues [active] 698969005037 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698969005038 Helix-turn-helix domain; Region: HTH_38; pfam13936 698969005039 Integrase core domain; Region: rve; pfam00665 698969005040 Integrase core domain; Region: rve_3; pfam13683 698969005041 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698969005042 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 698969005043 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 698969005044 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698969005045 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 698969005046 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698969005047 active site 698969005048 HIGH motif; other site 698969005049 nucleotide binding site [chemical binding]; other site 698969005050 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698969005051 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 698969005052 active site 698969005053 KMSKS motif; other site 698969005054 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 698969005055 tRNA binding surface [nucleotide binding]; other site 698969005056 anticodon binding site; other site 698969005057 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 698969005058 malate dehydrogenase; Provisional; Region: PRK05442 698969005059 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 698969005060 NAD(P) binding site [chemical binding]; other site 698969005061 dimer interface [polypeptide binding]; other site 698969005062 malate binding site [chemical binding]; other site 698969005063 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698969005064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698969005065 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 698969005066 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 698969005067 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 698969005068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698969005069 Walker A motif; other site 698969005070 ATP binding site [chemical binding]; other site 698969005071 Walker B motif; other site 698969005072 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 698969005073 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698969005074 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698969005075 glutamine binding [chemical binding]; other site 698969005076 catalytic triad [active] 698969005077 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 698969005078 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698969005079 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 698969005080 substrate-cofactor binding pocket; other site 698969005081 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698969005082 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 698969005083 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698969005084 oligomer interface [polypeptide binding]; other site 698969005085 active site residues [active] 698969005086 Clp protease; Region: CLP_protease; pfam00574 698969005087 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698969005088 oligomer interface [polypeptide binding]; other site 698969005089 active site residues [active] 698969005090 trigger factor; Provisional; Region: tig; PRK01490 698969005091 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698969005092 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 698969005093 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 698969005094 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698969005095 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698969005096 catalytic residues [active] 698969005097 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 698969005098 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 698969005099 Zn binding site [ion binding]; other site 698969005100 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698969005101 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698969005102 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 698969005103 apolar tunnel; other site 698969005104 heme binding site [chemical binding]; other site 698969005105 dimerization interface [polypeptide binding]; other site 698969005106 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698969005107 active site 698969005108 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 698969005109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969005110 Walker A/P-loop; other site 698969005111 ATP binding site [chemical binding]; other site 698969005112 Q-loop/lid; other site 698969005113 ABC transporter signature motif; other site 698969005114 Walker B; other site 698969005115 D-loop; other site 698969005116 H-loop/switch region; other site 698969005117 ABC transporter; Region: ABC_tran_2; pfam12848 698969005118 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698969005119 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698969005120 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698969005121 dimer interface [polypeptide binding]; other site 698969005122 ssDNA binding site [nucleotide binding]; other site 698969005123 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698969005124 Copper resistance protein D; Region: CopD; pfam05425 698969005125 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 698969005126 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 698969005127 Carbon starvation protein CstA; Region: CstA; pfam02554 698969005128 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 698969005129 Protein of unknown function (DUF466); Region: DUF466; pfam04328 698969005130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969005131 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698969005132 putative substrate translocation pore; other site 698969005133 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 698969005134 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 698969005135 NADP binding site [chemical binding]; other site 698969005136 dimer interface [polypeptide binding]; other site 698969005137 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698969005138 classical (c) SDRs; Region: SDR_c; cd05233 698969005139 NAD(P) binding site [chemical binding]; other site 698969005140 active site 698969005141 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 698969005142 catalytic site [active] 698969005143 putative active site [active] 698969005144 putative substrate binding site [chemical binding]; other site 698969005145 dimer interface [polypeptide binding]; other site 698969005146 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698969005147 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698969005148 inhibitor site; inhibition site 698969005149 active site 698969005150 dimer interface [polypeptide binding]; other site 698969005151 catalytic residue [active] 698969005152 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 698969005153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698969005154 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 698969005155 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698969005156 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 698969005157 conserved cis-peptide bond; other site 698969005158 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 698969005159 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 698969005160 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698969005161 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 698969005162 catalytic triad [active] 698969005163 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698969005164 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698969005165 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 698969005166 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698969005167 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 698969005168 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698969005169 phosphate binding site [ion binding]; other site 698969005170 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 698969005171 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 698969005172 active site 2 [active] 698969005173 active site 1 [active] 698969005174 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 698969005175 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698969005176 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 698969005177 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 698969005178 putative NAD(P) binding site [chemical binding]; other site 698969005179 active site 698969005180 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 698969005181 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 698969005182 active site 698969005183 Glucitol operon activator protein (GutM); Region: GutM; cl01890 698969005184 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 698969005185 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 698969005186 active site 698969005187 dimerization interface [polypeptide binding]; other site 698969005188 ribonuclease PH; Reviewed; Region: rph; PRK00173 698969005189 Ribonuclease PH; Region: RNase_PH_bact; cd11362 698969005190 hexamer interface [polypeptide binding]; other site 698969005191 active site 698969005192 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 698969005193 glutamate racemase; Provisional; Region: PRK00865 698969005194 Rhomboid family; Region: Rhomboid; cl11446 698969005195 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 698969005196 putative active site pocket [active] 698969005197 cleavage site 698969005198 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 698969005199 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 698969005200 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 698969005201 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 698969005202 active site 698969005203 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 698969005204 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698969005205 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698969005206 putative Mg++ binding site [ion binding]; other site 698969005207 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 698969005208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698969005209 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698969005210 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698969005211 active site 698969005212 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 698969005213 dimer interface [polypeptide binding]; other site 698969005214 putative active site [active] 698969005215 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 698969005216 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 698969005217 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 698969005218 phosphoserine phosphatase SerB; Region: serB; TIGR00338 698969005219 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698969005220 motif II; other site 698969005221 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 698969005222 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 698969005223 D-pathway; other site 698969005224 Putative ubiquinol binding site [chemical binding]; other site 698969005225 Low-spin heme (heme b) binding site [chemical binding]; other site 698969005226 Putative water exit pathway; other site 698969005227 Binuclear center (heme o3/CuB) [ion binding]; other site 698969005228 K-pathway; other site 698969005229 Putative proton exit pathway; other site 698969005230 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698969005231 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698969005232 dimer interface [polypeptide binding]; other site 698969005233 putative radical transfer pathway; other site 698969005234 diiron center [ion binding]; other site 698969005235 tyrosyl radical; other site 698969005236 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 698969005237 Ferritin-like domain; Region: Ferritin; pfam00210 698969005238 ferroxidase diiron center [ion binding]; other site 698969005239 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 698969005240 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 698969005241 Class I ribonucleotide reductase; Region: RNR_I; cd01679 698969005242 active site 698969005243 dimer interface [polypeptide binding]; other site 698969005244 catalytic residues [active] 698969005245 effector binding site; other site 698969005246 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698969005247 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698969005248 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698969005249 catalytic residues [active] 698969005250 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 698969005251 active site lid residues [active] 698969005252 substrate binding pocket [chemical binding]; other site 698969005253 catalytic residues [active] 698969005254 substrate-Mg2+ binding site; other site 698969005255 aspartate-rich region 1; other site 698969005256 aspartate-rich region 2; other site 698969005257 phytoene desaturase; Region: crtI_fam; TIGR02734 698969005258 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698969005259 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 698969005260 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 698969005261 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 698969005262 homodimer interface [polypeptide binding]; other site 698969005263 NAD binding pocket [chemical binding]; other site 698969005264 ATP binding pocket [chemical binding]; other site 698969005265 Mg binding site [ion binding]; other site 698969005266 active-site loop [active] 698969005267 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 698969005268 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698969005269 metal ion-dependent adhesion site (MIDAS); other site 698969005270 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 698969005271 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698969005272 catalytic residues [active] 698969005273 Methylamine utilisation protein MauE; Region: MauE; pfam07291 698969005274 phosphoglucomutase; Validated; Region: PRK07564 698969005275 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 698969005276 active site 698969005277 substrate binding site [chemical binding]; other site 698969005278 metal binding site [ion binding]; metal-binding site 698969005279 CrcB-like protein; Region: CRCB; pfam02537 698969005280 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698969005281 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698969005282 FtsX-like permease family; Region: FtsX; pfam02687 698969005283 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698969005284 FtsX-like permease family; Region: FtsX; pfam02687 698969005285 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698969005286 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698969005287 Walker A/P-loop; other site 698969005288 ATP binding site [chemical binding]; other site 698969005289 Q-loop/lid; other site 698969005290 ABC transporter signature motif; other site 698969005291 Walker B; other site 698969005292 D-loop; other site 698969005293 H-loop/switch region; other site 698969005294 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698969005295 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698969005296 hinge; other site 698969005297 active site 698969005298 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 698969005299 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 698969005300 GAF domain; Region: GAF_2; pfam13185 698969005301 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698969005302 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698969005303 DNA binding residues [nucleotide binding] 698969005304 dimerization interface [polypeptide binding]; other site 698969005305 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698969005306 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698969005307 dimer interface [polypeptide binding]; other site 698969005308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698969005309 catalytic residue [active] 698969005310 serine O-acetyltransferase; Region: cysE; TIGR01172 698969005311 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 698969005312 trimer interface [polypeptide binding]; other site 698969005313 active site 698969005314 substrate binding site [chemical binding]; other site 698969005315 CoA binding site [chemical binding]; other site 698969005316 Predicted acetyltransferase [General function prediction only]; Region: COG2388 698969005317 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 698969005318 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 698969005319 putative active site [active] 698969005320 metal binding site [ion binding]; metal-binding site 698969005321 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698969005322 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 698969005323 DNA methylase; Region: N6_N4_Mtase; pfam01555 698969005324 DNA methylase; Region: N6_N4_Mtase; pfam01555 698969005325 potential frameshift: common BLAST hit: gi|172041140|ref|YP_001800854.1| transposase for insertion sequence 698969005326 HTH-like domain; Region: HTH_21; pfam13276 698969005327 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 698969005328 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 698969005329 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698969005330 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698969005331 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 698969005332 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 698969005333 Walker A/P-loop; other site 698969005334 ATP binding site [chemical binding]; other site 698969005335 Q-loop/lid; other site 698969005336 ABC transporter signature motif; other site 698969005337 Walker B; other site 698969005338 D-loop; other site 698969005339 H-loop/switch region; other site 698969005340 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 698969005341 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969005342 Walker A/P-loop; other site 698969005343 ATP binding site [chemical binding]; other site 698969005344 Q-loop/lid; other site 698969005345 ABC transporter signature motif; other site 698969005346 Walker B; other site 698969005347 D-loop; other site 698969005348 H-loop/switch region; other site 698969005349 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 698969005350 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 698969005351 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 698969005352 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 698969005353 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 698969005354 FMN binding site [chemical binding]; other site 698969005355 active site 698969005356 catalytic residues [active] 698969005357 substrate binding site [chemical binding]; other site 698969005358 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 698969005359 PhoU domain; Region: PhoU; pfam01895 698969005360 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 698969005361 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 698969005362 Walker A/P-loop; other site 698969005363 ATP binding site [chemical binding]; other site 698969005364 Q-loop/lid; other site 698969005365 ABC transporter signature motif; other site 698969005366 Walker B; other site 698969005367 D-loop; other site 698969005368 H-loop/switch region; other site 698969005369 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 698969005370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698969005371 dimer interface [polypeptide binding]; other site 698969005372 conserved gate region; other site 698969005373 putative PBP binding loops; other site 698969005374 ABC-ATPase subunit interface; other site 698969005375 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 698969005376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698969005377 dimer interface [polypeptide binding]; other site 698969005378 conserved gate region; other site 698969005379 putative PBP binding loops; other site 698969005380 ABC-ATPase subunit interface; other site 698969005381 PBP superfamily domain; Region: PBP_like_2; cl17296 698969005382 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 698969005383 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698969005384 Coenzyme A binding pocket [chemical binding]; other site 698969005385 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698969005386 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698969005387 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 698969005388 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 698969005389 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 698969005390 heme-binding site [chemical binding]; other site 698969005391 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 698969005392 substrate binding site [chemical binding]; other site 698969005393 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 698969005394 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 698969005395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698969005396 catalytic residue [active] 698969005397 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 698969005398 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 698969005399 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698969005400 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 698969005401 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 698969005402 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 698969005403 dimerization interface [polypeptide binding]; other site 698969005404 putative ATP binding site [chemical binding]; other site 698969005405 amidophosphoribosyltransferase; Provisional; Region: PRK07847 698969005406 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 698969005407 active site 698969005408 tetramer interface [polypeptide binding]; other site 698969005409 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698969005410 active site 698969005411 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 698969005412 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 698969005413 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698969005414 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698969005415 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698969005416 dimer interface [polypeptide binding]; other site 698969005417 putative radical transfer pathway; other site 698969005418 diiron center [ion binding]; other site 698969005419 tyrosyl radical; other site 698969005420 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 698969005421 catalytic residues [active] 698969005422 dimer interface [polypeptide binding]; other site 698969005423 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 698969005424 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698969005425 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 698969005426 ATP binding site [chemical binding]; other site 698969005427 active site 698969005428 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 698969005429 substrate binding site [chemical binding]; other site 698969005430 adenylosuccinate lyase; Region: purB; TIGR00928 698969005431 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 698969005432 tetramer interface [polypeptide binding]; other site 698969005433 aspartate aminotransferase; Provisional; Region: PRK05764 698969005434 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698969005435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698969005436 homodimer interface [polypeptide binding]; other site 698969005437 catalytic residue [active] 698969005438 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 698969005439 TrkA-N domain; Region: TrkA_N; pfam02254 698969005440 TrkA-C domain; Region: TrkA_C; pfam02080 698969005441 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 698969005442 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 698969005443 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 698969005444 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 698969005445 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 698969005446 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 698969005447 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 698969005448 nucleotide binding site/active site [active] 698969005449 HIT family signature motif; other site 698969005450 catalytic residue [active] 698969005451 PGAP1-like protein; Region: PGAP1; pfam07819 698969005452 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698969005453 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698969005454 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698969005455 dimerization interface [polypeptide binding]; other site 698969005456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698969005457 dimer interface [polypeptide binding]; other site 698969005458 phosphorylation site [posttranslational modification] 698969005459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698969005460 ATP binding site [chemical binding]; other site 698969005461 Mg2+ binding site [ion binding]; other site 698969005462 G-X-G motif; other site 698969005463 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698969005464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698969005465 active site 698969005466 phosphorylation site [posttranslational modification] 698969005467 intermolecular recognition site; other site 698969005468 dimerization interface [polypeptide binding]; other site 698969005469 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698969005470 DNA binding site [nucleotide binding] 698969005471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969005472 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698969005473 putative substrate translocation pore; other site 698969005474 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698969005475 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698969005476 xanthine permease; Region: pbuX; TIGR03173 698969005477 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 698969005478 pyruvate dehydrogenase; Provisional; Region: PRK06546 698969005479 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 698969005480 PYR/PP interface [polypeptide binding]; other site 698969005481 dimer interface [polypeptide binding]; other site 698969005482 tetramer interface [polypeptide binding]; other site 698969005483 TPP binding site [chemical binding]; other site 698969005484 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698969005485 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 698969005486 TPP-binding site [chemical binding]; other site 698969005487 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698969005488 Uncharacterized conserved protein [Function unknown]; Region: COG3610 698969005489 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698969005490 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698969005491 Uncharacterized conserved protein [Function unknown]; Region: COG3610 698969005492 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 698969005493 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 698969005494 active site 698969005495 homotetramer interface [polypeptide binding]; other site 698969005496 META domain; Region: META; cl01245 698969005497 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 698969005498 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 698969005499 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698969005500 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698969005501 DNA binding site [nucleotide binding] 698969005502 domain linker motif; other site 698969005503 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 698969005504 putative dimerization interface [polypeptide binding]; other site 698969005505 putative ligand binding site [chemical binding]; other site 698969005506 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698969005507 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 698969005508 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698969005509 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 698969005510 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698969005511 active site 698969005512 HIGH motif; other site 698969005513 nucleotide binding site [chemical binding]; other site 698969005514 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698969005515 KMSKS motif; other site 698969005516 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698969005517 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 698969005518 homotrimer interaction site [polypeptide binding]; other site 698969005519 zinc binding site [ion binding]; other site 698969005520 CDP-binding sites; other site 698969005521 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 698969005522 substrate binding site; other site 698969005523 dimer interface; other site 698969005524 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 698969005525 DNA repair protein RadA; Provisional; Region: PRK11823 698969005526 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698969005527 Walker A motif; other site 698969005528 ATP binding site [chemical binding]; other site 698969005529 Walker B motif; other site 698969005530 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698969005531 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 698969005532 active site clefts [active] 698969005533 zinc binding site [ion binding]; other site 698969005534 dimer interface [polypeptide binding]; other site 698969005535 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698969005536 endonuclease III; Region: ENDO3c; smart00478 698969005537 minor groove reading motif; other site 698969005538 helix-hairpin-helix signature motif; other site 698969005539 substrate binding pocket [chemical binding]; other site 698969005540 active site 698969005541 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698969005542 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698969005543 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 698969005544 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 698969005545 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 698969005546 Clp amino terminal domain; Region: Clp_N; pfam02861 698969005547 Clp amino terminal domain; Region: Clp_N; pfam02861 698969005548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698969005549 Walker A motif; other site 698969005550 ATP binding site [chemical binding]; other site 698969005551 Walker B motif; other site 698969005552 arginine finger; other site 698969005553 UvrB/uvrC motif; Region: UVR; pfam02151 698969005554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698969005555 Walker A motif; other site 698969005556 ATP binding site [chemical binding]; other site 698969005557 Walker B motif; other site 698969005558 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698969005559 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 698969005560 oligomer interface [polypeptide binding]; other site 698969005561 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698969005562 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698969005563 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 698969005564 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698969005565 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698969005566 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 698969005567 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 698969005568 active site 698969005569 catalytic motif [active] 698969005570 Zn binding site [ion binding]; other site 698969005571 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 698969005572 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 698969005573 Nucleoside recognition; Region: Gate; pfam07670 698969005574 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 698969005575 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 698969005576 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698969005577 dimer interface [polypeptide binding]; other site 698969005578 putative anticodon binding site; other site 698969005579 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698969005580 motif 1; other site 698969005581 dimer interface [polypeptide binding]; other site 698969005582 active site 698969005583 motif 2; other site 698969005584 motif 3; other site 698969005585 YcaO-like family; Region: YcaO; pfam02624 698969005586 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 698969005587 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 698969005588 NADPH bind site [chemical binding]; other site 698969005589 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 698969005590 dimer interface [polypeptide binding]; other site 698969005591 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 698969005592 SpaB C-terminal domain; Region: SpaB_C; pfam14028 698969005593 YcaO-like family; Region: YcaO; pfam02624 698969005594 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 698969005595 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698969005596 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698969005597 Walker A/P-loop; other site 698969005598 ATP binding site [chemical binding]; other site 698969005599 Q-loop/lid; other site 698969005600 ABC transporter signature motif; other site 698969005601 Walker B; other site 698969005602 D-loop; other site 698969005603 H-loop/switch region; other site 698969005604 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698969005605 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 698969005606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 698969005607 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698969005608 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698969005609 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698969005610 active site 698969005611 KMSKS motif; other site 698969005612 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 698969005613 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 698969005614 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 698969005615 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 698969005616 catalytic center binding site [active] 698969005617 ATP binding site [chemical binding]; other site 698969005618 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 698969005619 homooctamer interface [polypeptide binding]; other site 698969005620 active site 698969005621 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698969005622 dihydropteroate synthase; Region: DHPS; TIGR01496 698969005623 substrate binding pocket [chemical binding]; other site 698969005624 dimer interface [polypeptide binding]; other site 698969005625 inhibitor binding site; inhibition site 698969005626 Protein of unknown function, DUF393; Region: DUF393; pfam04134 698969005627 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 698969005628 homodecamer interface [polypeptide binding]; other site 698969005629 GTP cyclohydrolase I; Provisional; Region: PLN03044 698969005630 active site 698969005631 putative catalytic site residues [active] 698969005632 zinc binding site [ion binding]; other site 698969005633 GTP-CH-I/GFRP interaction surface; other site 698969005634 FtsH Extracellular; Region: FtsH_ext; pfam06480 698969005635 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 698969005636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698969005637 Walker A motif; other site 698969005638 ATP binding site [chemical binding]; other site 698969005639 Walker B motif; other site 698969005640 arginine finger; other site 698969005641 Peptidase family M41; Region: Peptidase_M41; pfam01434 698969005642 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698969005643 active site 698969005644 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 698969005645 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 698969005646 Ligand Binding Site [chemical binding]; other site 698969005647 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 698969005648 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 698969005649 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 698969005650 dimer interface [polypeptide binding]; other site 698969005651 substrate binding site [chemical binding]; other site 698969005652 metal binding sites [ion binding]; metal-binding site 698969005653 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698969005654 active site residue [active] 698969005655 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698969005656 MarR family; Region: MarR_2; cl17246 698969005657 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698969005658 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 698969005659 acyl-activating enzyme (AAE) consensus motif; other site 698969005660 AMP binding site [chemical binding]; other site 698969005661 active site 698969005662 CoA binding site [chemical binding]; other site 698969005663 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698969005664 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 698969005665 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698969005666 putative trimer interface [polypeptide binding]; other site 698969005667 putative CoA binding site [chemical binding]; other site 698969005668 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698969005669 putative trimer interface [polypeptide binding]; other site 698969005670 putative CoA binding site [chemical binding]; other site 698969005671 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698969005672 metal ion-dependent adhesion site (MIDAS); other site 698969005673 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698969005674 active site 698969005675 catalytic site [active] 698969005676 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698969005677 Secretory lipase; Region: LIP; pfam03583 698969005678 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698969005679 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 698969005680 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698969005681 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698969005682 ring oligomerisation interface [polypeptide binding]; other site 698969005683 ATP/Mg binding site [chemical binding]; other site 698969005684 stacking interactions; other site 698969005685 hinge regions; other site 698969005686 Fic family protein [Function unknown]; Region: COG3177 698969005687 Fic/DOC family; Region: Fic; pfam02661 698969005688 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 698969005689 hypothetical protein; Reviewed; Region: PRK09588 698969005690 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 698969005691 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 698969005692 FMN binding site [chemical binding]; other site 698969005693 active site 698969005694 substrate binding site [chemical binding]; other site 698969005695 catalytic residue [active] 698969005696 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 698969005697 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698969005698 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698969005699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969005700 Walker A/P-loop; other site 698969005701 ATP binding site [chemical binding]; other site 698969005702 Q-loop/lid; other site 698969005703 ABC transporter signature motif; other site 698969005704 Walker B; other site 698969005705 D-loop; other site 698969005706 H-loop/switch region; other site 698969005707 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698969005708 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 698969005709 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 698969005710 amidohydrolase; Region: amidohydrolases; TIGR01891 698969005711 metal binding site [ion binding]; metal-binding site 698969005712 AAA domain; Region: AAA_21; pfam13304 698969005713 Restriction endonuclease [Defense mechanisms]; Region: COG3587 698969005714 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698969005715 ATP binding site [chemical binding]; other site 698969005716 potential frameshift: common BLAST hit: gi|297571356|ref|YP_003697130.1| adenine-specific DNA-methyltransferase 698969005717 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 698969005718 DNA methylase; Region: N6_N4_Mtase; pfam01555 698969005719 DNA methylase; Region: N6_N4_Mtase; cl17433 698969005720 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698969005721 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698969005722 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698969005723 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698969005724 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698969005725 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698969005726 ATP binding site [chemical binding]; other site 698969005727 putative Mg++ binding site [ion binding]; other site 698969005728 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698969005729 nucleotide binding region [chemical binding]; other site 698969005730 ATP-binding site [chemical binding]; other site 698969005731 Abi-like protein; Region: Abi_2; cl01988 698969005732 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698969005733 Coenzyme A binding pocket [chemical binding]; other site 698969005734 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698969005735 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698969005736 non-specific DNA binding site [nucleotide binding]; other site 698969005737 salt bridge; other site 698969005738 sequence-specific DNA binding site [nucleotide binding]; other site 698969005739 HipA N-terminal domain; Region: Couple_hipA; cl11853 698969005740 HipA-like N-terminal domain; Region: HipA_N; pfam07805 698969005741 HipA-like C-terminal domain; Region: HipA_C; pfam07804 698969005742 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 698969005743 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 698969005744 HicB family; Region: HicB; pfam05534 698969005745 putative transposase OrfB; Reviewed; Region: PHA02517 698969005746 HTH-like domain; Region: HTH_21; pfam13276 698969005747 Integrase core domain; Region: rve; pfam00665 698969005748 Integrase core domain; Region: rve_2; pfam13333 698969005749 Homeodomain-like domain; Region: HTH_23; cl17451 698969005750 peptide chain release factor 2; Validated; Region: prfB; PRK00578 698969005751 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 698969005752 hypothetical protein; Provisional; Region: PRK07907 698969005753 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 698969005754 active site 698969005755 metal binding site [ion binding]; metal-binding site 698969005756 dimer interface [polypeptide binding]; other site 698969005757 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698969005758 carboxylate-amine ligase; Provisional; Region: PRK13517 698969005759 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 698969005760 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698969005761 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698969005762 active site 698969005763 catalytic residues [active] 698969005764 metal binding site [ion binding]; metal-binding site 698969005765 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698969005766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698969005767 Coenzyme A binding pocket [chemical binding]; other site 698969005768 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698969005769 putative catalytic site [active] 698969005770 putative metal binding site [ion binding]; other site 698969005771 putative phosphate binding site [ion binding]; other site 698969005772 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 698969005773 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 698969005774 putative active site [active] 698969005775 catalytic site [active] 698969005776 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 698969005777 putative active site [active] 698969005778 catalytic site [active] 698969005779 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698969005780 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698969005781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969005782 Walker A/P-loop; other site 698969005783 ATP binding site [chemical binding]; other site 698969005784 Q-loop/lid; other site 698969005785 ABC transporter signature motif; other site 698969005786 Walker B; other site 698969005787 D-loop; other site 698969005788 H-loop/switch region; other site 698969005789 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 698969005790 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698969005791 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698969005792 substrate binding pocket [chemical binding]; other site 698969005793 membrane-bound complex binding site; other site 698969005794 hinge residues; other site 698969005795 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698969005796 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698969005797 active site 698969005798 ATP binding site [chemical binding]; other site 698969005799 substrate binding site [chemical binding]; other site 698969005800 activation loop (A-loop); other site 698969005801 propionate/acetate kinase; Provisional; Region: PRK12379 698969005802 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 698969005803 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 698969005804 ferredoxin-NADP+ reductase; Region: PLN02852 698969005805 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698969005806 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698969005807 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 698969005808 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698969005809 active site 698969005810 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698969005811 putative active site [active] 698969005812 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 698969005813 Cna protein B-type domain; Region: Cna_B; pfam05738 698969005814 Cna protein B-type domain; Region: Cna_B; pfam05738 698969005815 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 698969005816 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 698969005817 GDP-binding site [chemical binding]; other site 698969005818 ACT binding site; other site 698969005819 IMP binding site; other site 698969005820 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 698969005821 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 698969005822 active site 698969005823 metal binding site [ion binding]; metal-binding site 698969005824 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 698969005825 acetaldehyde dehydrogenase; Validated; Region: PRK08300 698969005826 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698969005827 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 698969005828 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 698969005829 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 698969005830 active site 698969005831 catalytic residues [active] 698969005832 metal binding site [ion binding]; metal-binding site 698969005833 DmpG-like communication domain; Region: DmpG_comm; pfam07836 698969005834 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698969005835 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 698969005836 Bacterial transcriptional regulator; Region: IclR; pfam01614 698969005837 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 698969005838 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 698969005839 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 698969005840 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 698969005841 iron-sulfur cluster [ion binding]; other site 698969005842 [2Fe-2S] cluster binding site [ion binding]; other site 698969005843 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 698969005844 beta subunit interface [polypeptide binding]; other site 698969005845 alpha subunit interface [polypeptide binding]; other site 698969005846 active site 698969005847 substrate binding site [chemical binding]; other site 698969005848 Fe binding site [ion binding]; other site 698969005849 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 698969005850 [2Fe-2S] cluster binding site [ion binding]; other site 698969005851 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 698969005852 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698969005853 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 698969005854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698969005855 NAD(P) binding site [chemical binding]; other site 698969005856 active site 698969005857 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 698969005858 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698969005859 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 698969005860 acyl-activating enzyme (AAE) consensus motif; other site 698969005861 acyl-activating enzyme (AAE) consensus motif; other site 698969005862 putative AMP binding site [chemical binding]; other site 698969005863 putative active site [active] 698969005864 putative CoA binding site [chemical binding]; other site 698969005865 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 698969005866 CoenzymeA binding site [chemical binding]; other site 698969005867 subunit interaction site [polypeptide binding]; other site 698969005868 PHB binding site; other site 698969005869 Predicted membrane protein [Function unknown]; Region: COG4129 698969005870 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698969005871 chromosome segregation protein; Provisional; Region: PRK03918 698969005872 Predicted membrane protein [Function unknown]; Region: COG4129 698969005873 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698969005874 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 698969005875 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698969005876 Integrase core domain; Region: rve; pfam00665 698969005877 Abi-like protein; Region: Abi_2; cl01988 698969005878 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698969005879 putative transporter; Provisional; Region: PRK09821 698969005880 GntP family permease; Region: GntP_permease; pfam02447 698969005881 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698969005882 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698969005883 NAD(P) binding site [chemical binding]; other site 698969005884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 698969005885 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698969005886 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698969005887 DNA-binding site [nucleotide binding]; DNA binding site 698969005888 FCD domain; Region: FCD; pfam07729 698969005889 Abi-like protein; Region: Abi_2; pfam07751 698969005890 potential frameshift: common BLAST hit: gi|172041139|ref|YP_001800853.1| transposase for insertion sequence 698969005891 Integrase core domain; Region: rve; pfam00665 698969005892 HTH-like domain; Region: HTH_21; pfam13276 698969005893 Cna protein B-type domain; Region: Cna_B; pfam05738 698969005894 Cna protein B-type domain; Region: Cna_B; pfam05738 698969005895 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 698969005896 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 698969005897 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 698969005898 Integrase core domain; Region: rve; pfam00665 698969005899 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698969005900 Helix-turn-helix domain; Region: HTH_38; pfam13936 698969005901 Integrase core domain; Region: rve; pfam00665 698969005902 putative transposase OrfB; Reviewed; Region: PHA02517 698969005903 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 698969005904 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 698969005905 active site 698969005906 intersubunit interface [polypeptide binding]; other site 698969005907 zinc binding site [ion binding]; other site 698969005908 Na+ binding site [ion binding]; other site 698969005909 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 698969005910 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698969005911 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698969005912 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698969005913 active site 698969005914 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698969005915 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698969005916 active site residue [active] 698969005917 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698969005918 active site residue [active] 698969005919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698969005920 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 698969005921 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 698969005922 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 698969005923 Clp amino terminal domain; Region: Clp_N; pfam02861 698969005924 Clp amino terminal domain; Region: Clp_N; pfam02861 698969005925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698969005926 Walker A motif; other site 698969005927 ATP binding site [chemical binding]; other site 698969005928 Walker B motif; other site 698969005929 arginine finger; other site 698969005930 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698969005931 Walker A motif; other site 698969005932 ATP binding site [chemical binding]; other site 698969005933 Walker B motif; other site 698969005934 arginine finger; other site 698969005935 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698969005936 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698969005937 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 698969005938 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698969005939 Walker A/P-loop; other site 698969005940 ATP binding site [chemical binding]; other site 698969005941 Q-loop/lid; other site 698969005942 ABC transporter signature motif; other site 698969005943 Walker B; other site 698969005944 D-loop; other site 698969005945 H-loop/switch region; other site 698969005946 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698969005947 EamA-like transporter family; Region: EamA; pfam00892 698969005948 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698969005949 EamA-like transporter family; Region: EamA; pfam00892 698969005950 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 698969005951 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 698969005952 FAD binding pocket [chemical binding]; other site 698969005953 FAD binding motif [chemical binding]; other site 698969005954 phosphate binding motif [ion binding]; other site 698969005955 beta-alpha-beta structure motif; other site 698969005956 NAD binding pocket [chemical binding]; other site 698969005957 Predicted amidohydrolase [General function prediction only]; Region: COG0388 698969005958 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 698969005959 putative active site [active] 698969005960 catalytic triad [active] 698969005961 putative dimer interface [polypeptide binding]; other site 698969005962 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 698969005963 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 698969005964 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 698969005965 NAD binding site [chemical binding]; other site 698969005966 substrate binding site [chemical binding]; other site 698969005967 catalytic Zn binding site [ion binding]; other site 698969005968 tetramer interface [polypeptide binding]; other site 698969005969 structural Zn binding site [ion binding]; other site 698969005970 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698969005971 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698969005972 NAD(P) binding site [chemical binding]; other site 698969005973 catalytic residues [active] 698969005974 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 698969005975 DNA binding residues [nucleotide binding] 698969005976 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698969005977 putative dimer interface [polypeptide binding]; other site 698969005978 chaperone protein DnaJ; Provisional; Region: PRK14279 698969005979 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698969005980 HSP70 interaction site [polypeptide binding]; other site 698969005981 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698969005982 Zn binding sites [ion binding]; other site 698969005983 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698969005984 dimer interface [polypeptide binding]; other site 698969005985 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 698969005986 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 698969005987 dimer interface [polypeptide binding]; other site 698969005988 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 698969005989 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 698969005990 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 698969005991 nucleotide binding site [chemical binding]; other site 698969005992 NEF interaction site [polypeptide binding]; other site 698969005993 SBD interface [polypeptide binding]; other site 698969005994 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698969005995 PAS domain; Region: PAS_9; pfam13426 698969005996 putative active site [active] 698969005997 heme pocket [chemical binding]; other site 698969005998 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698969005999 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698969006000 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698969006001 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698969006002 Walker A/P-loop; other site 698969006003 ATP binding site [chemical binding]; other site 698969006004 Q-loop/lid; other site 698969006005 ABC transporter signature motif; other site 698969006006 Walker B; other site 698969006007 D-loop; other site 698969006008 H-loop/switch region; other site 698969006009 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698969006010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698969006011 dimer interface [polypeptide binding]; other site 698969006012 conserved gate region; other site 698969006013 putative PBP binding loops; other site 698969006014 ABC-ATPase subunit interface; other site 698969006015 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698969006016 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 698969006017 Walker A/P-loop; other site 698969006018 ATP binding site [chemical binding]; other site 698969006019 Q-loop/lid; other site 698969006020 ABC transporter signature motif; other site 698969006021 Walker B; other site 698969006022 D-loop; other site 698969006023 H-loop/switch region; other site 698969006024 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698969006025 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698969006026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698969006027 dimer interface [polypeptide binding]; other site 698969006028 conserved gate region; other site 698969006029 putative PBP binding loops; other site 698969006030 ABC-ATPase subunit interface; other site 698969006031 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698969006032 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 698969006033 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698969006034 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698969006035 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 698969006036 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 698969006037 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 698969006038 dimerization interface [polypeptide binding]; other site 698969006039 ATP binding site [chemical binding]; other site 698969006040 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 698969006041 dimerization interface [polypeptide binding]; other site 698969006042 ATP binding site [chemical binding]; other site 698969006043 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 698969006044 putative active site [active] 698969006045 catalytic triad [active] 698969006046 nucleosidase; Provisional; Region: PRK05634 698969006047 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 698969006048 Permease; Region: Permease; cl00510 698969006049 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698969006050 4Fe-4S binding domain; Region: Fer4; cl02805 698969006051 Cysteine-rich domain; Region: CCG; pfam02754 698969006052 Cysteine-rich domain; Region: CCG; pfam02754 698969006053 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 698969006054 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698969006055 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 698969006056 putative NAD(P) binding site [chemical binding]; other site 698969006057 catalytic Zn binding site [ion binding]; other site 698969006058 aminotransferase AlaT; Validated; Region: PRK09265 698969006059 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698969006060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698969006061 homodimer interface [polypeptide binding]; other site 698969006062 catalytic residue [active] 698969006063 YibE/F-like protein; Region: YibE_F; pfam07907 698969006064 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 698969006065 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 698969006066 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698969006067 dimer interface [polypeptide binding]; other site 698969006068 putative anticodon binding site; other site 698969006069 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698969006070 motif 1; other site 698969006071 dimer interface [polypeptide binding]; other site 698969006072 active site 698969006073 motif 2; other site 698969006074 motif 3; other site 698969006075 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698969006076 Protein of unknown function (DUF998); Region: DUF998; pfam06197 698969006077 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 698969006078 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 698969006079 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 698969006080 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698969006081 trimer interface [polypeptide binding]; other site 698969006082 active site 698969006083 BRO family, N-terminal domain; Region: Bro-N; smart01040 698969006084 Abi-like protein; Region: Abi_2; cl01988 698969006085 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 698969006086 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698969006087 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698969006088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969006089 Walker A/P-loop; other site 698969006090 ATP binding site [chemical binding]; other site 698969006091 Q-loop/lid; other site 698969006092 ABC transporter signature motif; other site 698969006093 Walker B; other site 698969006094 D-loop; other site 698969006095 H-loop/switch region; other site 698969006096 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698969006097 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969006098 Walker A/P-loop; other site 698969006099 ATP binding site [chemical binding]; other site 698969006100 Q-loop/lid; other site 698969006101 ABC transporter signature motif; other site 698969006102 Walker B; other site 698969006103 D-loop; other site 698969006104 H-loop/switch region; other site 698969006105 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 698969006106 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 698969006107 active site 698969006108 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 698969006109 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698969006110 Condensation domain; Region: Condensation; pfam00668 698969006111 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698969006112 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698969006113 Condensation domain; Region: Condensation; pfam00668 698969006114 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698969006115 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698969006116 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698969006117 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 698969006118 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698969006119 Condensation domain; Region: Condensation; pfam00668 698969006120 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698969006121 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 698969006122 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 698969006123 acyl-activating enzyme (AAE) consensus motif; other site 698969006124 AMP binding site [chemical binding]; other site 698969006125 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698969006126 Condensation domain; Region: Condensation; pfam00668 698969006127 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698969006128 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698969006129 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698969006130 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 698969006131 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698969006132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698969006133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698969006134 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698969006135 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698969006136 Walker A/P-loop; other site 698969006137 ATP binding site [chemical binding]; other site 698969006138 Q-loop/lid; other site 698969006139 ABC transporter signature motif; other site 698969006140 Walker B; other site 698969006141 D-loop; other site 698969006142 H-loop/switch region; other site 698969006143 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969006144 Walker A/P-loop; other site 698969006145 ATP binding site [chemical binding]; other site 698969006146 Q-loop/lid; other site 698969006147 ABC transporter signature motif; other site 698969006148 Walker B; other site 698969006149 D-loop; other site 698969006150 H-loop/switch region; other site 698969006151 metabolite-proton symporter; Region: 2A0106; TIGR00883 698969006152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969006153 putative substrate translocation pore; other site 698969006154 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698969006155 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 698969006156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969006157 putative substrate translocation pore; other site 698969006158 YwiC-like protein; Region: YwiC; pfam14256 698969006159 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698969006160 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698969006161 VanW like protein; Region: VanW; pfam04294 698969006162 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 698969006163 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 698969006164 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 698969006165 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 698969006166 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698969006167 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698969006168 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698969006169 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698969006170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698969006171 S-adenosylmethionine binding site [chemical binding]; other site 698969006172 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 698969006173 active site 698969006174 substrate-binding site [chemical binding]; other site 698969006175 metal-binding site [ion binding] 698969006176 GTP binding site [chemical binding]; other site 698969006177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698969006178 S-adenosylmethionine binding site [chemical binding]; other site 698969006179 LabA_like proteins; Region: LabA_like; cd06167 698969006180 putative metal binding site [ion binding]; other site 698969006181 MMPL family; Region: MMPL; pfam03176 698969006182 Protein of unknown function (DUF496); Region: DUF496; cl09955 698969006183 MMPL family; Region: MMPL; pfam03176 698969006184 Predicted integral membrane protein [Function unknown]; Region: COG0392 698969006185 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 698969006186 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 698969006187 TQXA domain; Region: TQXA_dom; TIGR03934 698969006188 potential frameshift: common BLAST hit: gi|337291728|ref|YP_004630749.1| protease CP40 698969006189 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 698969006190 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 698969006191 potential frameshift: common BLAST hit: gi|38234729|ref|NP_940496.1| propionyl-CoA carboxylase subunit beta 698969006192 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698969006193 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698969006194 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698969006195 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698969006196 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698969006197 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 698969006198 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 698969006199 active site 698969006200 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 698969006201 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698969006202 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 698969006203 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 698969006204 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 698969006205 acyl-activating enzyme (AAE) consensus motif; other site 698969006206 active site 698969006207 Cutinase; Region: Cutinase; pfam01083 698969006208 Putative esterase; Region: Esterase; pfam00756 698969006209 S-formylglutathione hydrolase; Region: PLN02442 698969006210 LGFP repeat; Region: LGFP; pfam08310 698969006211 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698969006212 LGFP repeat; Region: LGFP; pfam08310 698969006213 LGFP repeat; Region: LGFP; pfam08310 698969006214 Predicted esterase [General function prediction only]; Region: COG0627 698969006215 S-formylglutathione hydrolase; Region: PLN02442 698969006216 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 698969006217 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 698969006218 UbiA prenyltransferase family; Region: UbiA; pfam01040 698969006219 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698969006220 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698969006221 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698969006222 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698969006223 active site 698969006224 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698969006225 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698969006226 NAD(P) binding site [chemical binding]; other site 698969006227 catalytic residues [active] 698969006228 BCCT family transporter; Region: BCCT; cl00569 698969006229 choline dehydrogenase; Validated; Region: PRK02106 698969006230 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698969006231 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 698969006232 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698969006233 UDP-galactopyranose mutase; Region: GLF; pfam03275 698969006234 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 698969006235 Firmicute plasmid replication protein (RepL); Region: RepL; pfam05732 698969006236 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 698969006237 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698969006238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969006239 ABC transporter signature motif; other site 698969006240 Walker B; other site 698969006241 D-loop; other site 698969006242 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698969006243 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698969006244 amidase catalytic site [active] 698969006245 Zn binding residues [ion binding]; other site 698969006246 substrate binding site [chemical binding]; other site 698969006247 LGFP repeat; Region: LGFP; pfam08310 698969006248 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 698969006249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698969006250 Integrase core domain; Region: rve; pfam00665 698969006251 Protein P3 of Potyviral polyprotein; Region: Potyvirid-P3; pfam13608 698969006252 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698969006253 MULE transposase domain; Region: MULE; pfam10551 698969006254 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698969006255 active site 698969006256 catalytic site [active] 698969006257 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698969006258 active site 698969006259 catalytic site [active] 698969006260 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698969006261 Cna protein B-type domain; Region: Cna_B; pfam05738 698969006262 Cna protein B-type domain; Region: Cna_B; pfam05738 698969006263 Cna protein B-type domain; Region: Cna_B; pfam05738 698969006264 Cna protein B-type domain; Region: Cna_B; pfam05738 698969006265 Cna protein B-type domain; Region: Cna_B; pfam05738 698969006266 Cna protein B-type domain; Region: Cna_B; pfam05738 698969006267 HTH-like domain; Region: HTH_21; pfam13276 698969006268 potential frameshift: common BLAST hit: gi|172041139|ref|YP_001800853.1| transposase for insertion sequence 698969006269 Integrase core domain; Region: rve; pfam00665 698969006270 Integrase core domain; Region: rve_3; cl15866 698969006271 glycerol kinase; Provisional; Region: glpK; PRK00047 698969006272 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 698969006273 N- and C-terminal domain interface [polypeptide binding]; other site 698969006274 active site 698969006275 MgATP binding site [chemical binding]; other site 698969006276 catalytic site [active] 698969006277 metal binding site [ion binding]; metal-binding site 698969006278 putative homotetramer interface [polypeptide binding]; other site 698969006279 glycerol binding site [chemical binding]; other site 698969006280 homodimer interface [polypeptide binding]; other site 698969006281 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 698969006282 amphipathic channel; other site 698969006283 Asn-Pro-Ala signature motifs; other site 698969006284 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 698969006285 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698969006286 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698969006287 putative acyl-acceptor binding pocket; other site 698969006288 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698969006289 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698969006290 active site 698969006291 motif I; other site 698969006292 motif II; other site 698969006293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698969006294 seryl-tRNA synthetase; Provisional; Region: PRK05431 698969006295 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 698969006296 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 698969006297 dimer interface [polypeptide binding]; other site 698969006298 active site 698969006299 motif 1; other site 698969006300 motif 2; other site 698969006301 motif 3; other site 698969006302 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698969006303 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698969006304 DNA-binding site [nucleotide binding]; DNA binding site 698969006305 UTRA domain; Region: UTRA; pfam07702 698969006306 Septum formation; Region: Septum_form; pfam13845 698969006307 Septum formation; Region: Septum_form; pfam13845 698969006308 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 698969006309 AAA domain; Region: AAA_14; pfam13173 698969006310 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 698969006311 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698969006312 catalytic core [active] 698969006313 prephenate dehydratase; Provisional; Region: PRK11898 698969006314 Prephenate dehydratase; Region: PDT; pfam00800 698969006315 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 698969006316 putative L-Phe binding site [chemical binding]; other site 698969006317 Amidase; Region: Amidase; cl11426 698969006318 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698969006319 CAAX protease self-immunity; Region: Abi; pfam02517 698969006320 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 698969006321 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698969006322 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698969006323 amino acid carrier protein; Region: agcS; TIGR00835 698969006324 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698969006325 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 698969006326 catalytic triad [active] 698969006327 catalytic triad [active] 698969006328 oxyanion hole [active] 698969006329 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698969006330 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 698969006331 putative active site [active] 698969006332 catalytic site [active] 698969006333 putative metal binding site [ion binding]; other site 698969006334 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 698969006335 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 698969006336 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698969006337 NAD binding site [chemical binding]; other site 698969006338 dimer interface [polypeptide binding]; other site 698969006339 substrate binding site [chemical binding]; other site 698969006340 quinolinate synthetase; Provisional; Region: PRK09375 698969006341 L-aspartate oxidase; Provisional; Region: PRK06175 698969006342 FAD binding domain; Region: FAD_binding_2; pfam00890 698969006343 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 698969006344 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 698969006345 dimerization interface [polypeptide binding]; other site 698969006346 active site 698969006347 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 698969006348 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 698969006349 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 698969006350 Predicted flavoprotein [General function prediction only]; Region: COG0431 698969006351 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698969006352 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 698969006353 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 698969006354 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698969006355 Lsr2; Region: Lsr2; pfam11774 698969006356 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698969006357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698969006358 active site 698969006359 phosphorylation site [posttranslational modification] 698969006360 intermolecular recognition site; other site 698969006361 dimerization interface [polypeptide binding]; other site 698969006362 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698969006363 DNA binding residues [nucleotide binding] 698969006364 dimerization interface [polypeptide binding]; other site 698969006365 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698969006366 Histidine kinase; Region: HisKA_3; pfam07730 698969006367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698969006368 ATP binding site [chemical binding]; other site 698969006369 Mg2+ binding site [ion binding]; other site 698969006370 G-X-G motif; other site 698969006371 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 698969006372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969006373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969006374 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 698969006375 active site 698969006376 catalytic site [active] 698969006377 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 698969006378 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 698969006379 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698969006380 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698969006381 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698969006382 Ligand Binding Site [chemical binding]; other site 698969006383 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698969006384 Ligand Binding Site [chemical binding]; other site 698969006385 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 698969006386 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698969006387 probable active site [active] 698969006388 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698969006389 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698969006390 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698969006391 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698969006392 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969006393 Walker A/P-loop; other site 698969006394 ATP binding site [chemical binding]; other site 698969006395 Q-loop/lid; other site 698969006396 ABC transporter signature motif; other site 698969006397 Walker B; other site 698969006398 D-loop; other site 698969006399 H-loop/switch region; other site 698969006400 Predicted transcriptional regulators [Transcription]; Region: COG1725 698969006401 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698969006402 DNA-binding site [nucleotide binding]; DNA binding site 698969006403 LabA_like proteins; Region: LabA_like; cd06167 698969006404 putative metal binding site [ion binding]; other site 698969006405 Uncharacterized conserved protein [Function unknown]; Region: COG1432 698969006406 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698969006407 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698969006408 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698969006409 catalytic residues [active] 698969006410 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698969006411 metal-binding site [ion binding] 698969006412 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698969006413 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698969006414 metal-binding site [ion binding] 698969006415 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698969006416 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698969006417 benzoate transport; Region: 2A0115; TIGR00895 698969006418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969006419 putative substrate translocation pore; other site 698969006420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698969006421 replicative DNA helicase; Provisional; Region: PRK05636 698969006422 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 698969006423 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 698969006424 Walker A motif; other site 698969006425 ATP binding site [chemical binding]; other site 698969006426 Walker B motif; other site 698969006427 DNA binding loops [nucleotide binding] 698969006428 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 698969006429 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 698969006430 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 698969006431 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698969006432 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698969006433 dimer interface [polypeptide binding]; other site 698969006434 ssDNA binding site [nucleotide binding]; other site 698969006435 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698969006436 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 698969006437 Predicted integral membrane protein [Function unknown]; Region: COG5650 698969006438 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698969006439 Transglycosylase; Region: Transgly; pfam00912 698969006440 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698969006441 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698969006442 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698969006443 Ligand Binding Site [chemical binding]; other site 698969006444 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698969006445 Ligand Binding Site [chemical binding]; other site 698969006446 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698969006447 classical (c) SDRs; Region: SDR_c; cd05233 698969006448 NAD(P) binding site [chemical binding]; other site 698969006449 active site 698969006450 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698969006451 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698969006452 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 698969006453 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 698969006454 active site residue [active] 698969006455 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 698969006456 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698969006457 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 698969006458 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 698969006459 dimerization interface [polypeptide binding]; other site 698969006460 DPS ferroxidase diiron center [ion binding]; other site 698969006461 ion pore; other site 698969006462 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698969006463 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 698969006464 putative DNA binding site [nucleotide binding]; other site 698969006465 catalytic residue [active] 698969006466 putative H2TH interface [polypeptide binding]; other site 698969006467 putative catalytic residues [active] 698969006468 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698969006469 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698969006470 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 698969006471 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 698969006472 putative substrate binding site [chemical binding]; other site 698969006473 putative ATP binding site [chemical binding]; other site 698969006474 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 698969006475 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 698969006476 active site 698969006477 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698969006478 AAA domain; Region: AAA_31; pfam13614 698969006479 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698969006480 P-loop; other site 698969006481 Magnesium ion binding site [ion binding]; other site 698969006482 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698969006483 Magnesium ion binding site [ion binding]; other site 698969006484 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698969006485 Divergent AAA domain; Region: AAA_4; pfam04326 698969006486 Divergent AAA domain; Region: AAA_4; pfam04326 698969006487 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698969006488 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698969006489 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698969006490 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698969006491 ATP binding site [chemical binding]; other site 698969006492 putative Mg++ binding site [ion binding]; other site 698969006493 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 698969006494 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698969006495 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 698969006496 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 698969006497 nucleotide binding site/active site [active] 698969006498 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 698969006499 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 698969006500 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698969006501 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698969006502 ATP binding site [chemical binding]; other site 698969006503 putative Mg++ binding site [ion binding]; other site 698969006504 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 698969006505 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 698969006506 HsdM N-terminal domain; Region: HsdM_N; pfam12161 698969006507 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 698969006508 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698969006509 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698969006510 non-specific DNA binding site [nucleotide binding]; other site 698969006511 salt bridge; other site 698969006512 sequence-specific DNA binding site [nucleotide binding]; other site 698969006513 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 698969006514 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698969006515 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 698969006516 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 698969006517 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 698969006518 Uncharacterized conserved protein [Function unknown]; Region: COG3410 698969006519 Fic family protein [Function unknown]; Region: COG3177 698969006520 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698969006521 Fic/DOC family; Region: Fic; pfam02661 698969006522 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 698969006523 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 698969006524 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 698969006525 E-class dimer interface [polypeptide binding]; other site 698969006526 P-class dimer interface [polypeptide binding]; other site 698969006527 active site 698969006528 Cu2+ binding site [ion binding]; other site 698969006529 Zn2+ binding site [ion binding]; other site 698969006530 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 698969006531 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698969006532 active site 698969006533 HIGH motif; other site 698969006534 nucleotide binding site [chemical binding]; other site 698969006535 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698969006536 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698969006537 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698969006538 active site 698969006539 KMSKS motif; other site 698969006540 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 698969006541 tRNA binding surface [nucleotide binding]; other site 698969006542 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698969006543 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698969006544 Walker A/P-loop; other site 698969006545 ATP binding site [chemical binding]; other site 698969006546 Q-loop/lid; other site 698969006547 ABC transporter signature motif; other site 698969006548 Walker B; other site 698969006549 D-loop; other site 698969006550 H-loop/switch region; other site 698969006551 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698969006552 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698969006553 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698969006554 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698969006555 Histidine kinase; Region: HisKA_3; pfam07730 698969006556 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698969006557 ATP binding site [chemical binding]; other site 698969006558 G-X-G motif; other site 698969006559 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698969006560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698969006561 active site 698969006562 phosphorylation site [posttranslational modification] 698969006563 intermolecular recognition site; other site 698969006564 dimerization interface [polypeptide binding]; other site 698969006565 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698969006566 DNA binding residues [nucleotide binding] 698969006567 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698969006568 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698969006569 Predicted membrane protein [Function unknown]; Region: COG1511 698969006570 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698969006571 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698969006572 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698969006573 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698969006574 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698969006575 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698969006576 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 698969006577 NAD(P) binding site [chemical binding]; other site 698969006578 catalytic residues [active] 698969006579 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698969006580 active site 698969006581 phosphorylation site [posttranslational modification] 698969006582 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 698969006583 active site 698969006584 P-loop; other site 698969006585 phosphorylation site [posttranslational modification] 698969006586 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 698969006587 potential frameshift: common BLAST hit: gi|38234873|ref|NP_940640.1| major secreted protein 698969006588 Predicted esterase [General function prediction only]; Region: COG0627 698969006589 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 698969006590 active site 698969006591 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698969006592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969006593 ABC transporter signature motif; other site 698969006594 Walker B; other site 698969006595 D-loop; other site 698969006596 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698969006597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698969006598 Walker A/P-loop; other site 698969006599 ATP binding site [chemical binding]; other site 698969006600 Q-loop/lid; other site 698969006601 ABC transporter signature motif; other site 698969006602 Walker B; other site 698969006603 D-loop; other site 698969006604 H-loop/switch region; other site 698969006605 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 698969006606 active site 698969006607 catalytic residues [active] 698969006608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 698969006609 hypothetical protein; Provisional; Region: PRK13663 698969006610 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698969006611 putative active site [active] 698969006612 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698969006613 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698969006614 SdpI/YhfL protein family; Region: SdpI; pfam13630 698969006615 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698969006616 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698969006617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698969006618 catalytic residue [active] 698969006619 anthranilate synthase component I; Provisional; Region: PRK13564 698969006620 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 698969006621 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698969006622 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698969006623 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698969006624 glutamine binding [chemical binding]; other site 698969006625 catalytic triad [active] 698969006626 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 698969006627 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698969006628 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698969006629 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 698969006630 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698969006631 active site 698969006632 ribulose/triose binding site [chemical binding]; other site 698969006633 phosphate binding site [ion binding]; other site 698969006634 substrate (anthranilate) binding pocket [chemical binding]; other site 698969006635 product (indole) binding pocket [chemical binding]; other site 698969006636 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 698969006637 active site 698969006638 Protein of unknown function (DUF454); Region: DUF454; cl01063 698969006639 pantoate--beta-alanine ligase; Region: panC; TIGR00018 698969006640 Pantoate-beta-alanine ligase; Region: PanC; cd00560 698969006641 active site 698969006642 ATP-binding site [chemical binding]; other site 698969006643 pantoate-binding site; other site 698969006644 HXXH motif; other site 698969006645 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 698969006646 oligomerization interface [polypeptide binding]; other site 698969006647 active site 698969006648 metal binding site [ion binding]; metal-binding site 698969006649 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698969006650 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698969006651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698969006652 catalytic residue [active] 698969006653 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 698969006654 substrate binding site [chemical binding]; other site 698969006655 active site 698969006656 catalytic residues [active] 698969006657 heterodimer interface [polypeptide binding]; other site 698969006658 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698969006659 iron-sulfur cluster [ion binding]; other site 698969006660 [2Fe-2S] cluster binding site [ion binding]; other site 698969006661 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 698969006662 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698969006663 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 698969006664 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 698969006665 hypothetical protein; Validated; Region: PRK00228 698969006666 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 698969006667 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 698969006668 active site 698969006669 NTP binding site [chemical binding]; other site 698969006670 metal binding triad [ion binding]; metal-binding site 698969006671 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 698969006672 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698969006673 Zn2+ binding site [ion binding]; other site 698969006674 Mg2+ binding site [ion binding]; other site 698969006675 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 698969006676 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698969006677 active site 698969006678 Ap6A binding site [chemical binding]; other site 698969006679 nudix motif; other site 698969006680 metal binding site [ion binding]; metal-binding site 698969006681 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 698969006682 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 698969006683 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 698969006684 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698969006685 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698969006686 DNA binding residues [nucleotide binding] 698969006687 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 698969006688 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698969006689 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698969006690 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698969006691 catalytic residues [active] 698969006692 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698969006693 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698969006694 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 698969006695 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 698969006696 active site 698969006697 metal binding site [ion binding]; metal-binding site 698969006698 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 698969006699 ParB-like nuclease domain; Region: ParBc; pfam02195 698969006700 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698969006701 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698969006702 P-loop; other site 698969006703 Magnesium ion binding site [ion binding]; other site 698969006704 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698969006705 Magnesium ion binding site [ion binding]; other site 698969006706 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 698969006707 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 698969006708 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 698969006709 ribonuclease P; Reviewed; Region: rnpA; PRK03459 698969006710 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399