-- dump date 20140619_051043 -- class Genbank::misc_feature -- table misc_feature_note -- id note 698970000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 698970000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698970000003 Walker A motif; other site 698970000004 ATP binding site [chemical binding]; other site 698970000005 Walker B motif; other site 698970000006 arginine finger; other site 698970000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 698970000008 DnaA box-binding interface [nucleotide binding]; other site 698970000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 698970000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 698970000011 putative DNA binding surface [nucleotide binding]; other site 698970000012 dimer interface [polypeptide binding]; other site 698970000013 beta-clamp/clamp loader binding surface; other site 698970000014 beta-clamp/translesion DNA polymerase binding surface; other site 698970000015 recombination protein F; Reviewed; Region: recF; PRK00064 698970000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 698970000017 Walker A/P-loop; other site 698970000018 ATP binding site [chemical binding]; other site 698970000019 Q-loop/lid; other site 698970000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970000021 ABC transporter signature motif; other site 698970000022 Walker B; other site 698970000023 D-loop; other site 698970000024 H-loop/switch region; other site 698970000025 hypothetical protein; Provisional; Region: PRK00111 698970000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 698970000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698970000028 ATP binding site [chemical binding]; other site 698970000029 Mg2+ binding site [ion binding]; other site 698970000030 G-X-G motif; other site 698970000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698970000032 anchoring element; other site 698970000033 dimer interface [polypeptide binding]; other site 698970000034 ATP binding site [chemical binding]; other site 698970000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 698970000036 active site 698970000037 putative metal-binding site [ion binding]; other site 698970000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698970000039 DNA gyrase subunit A; Validated; Region: PRK05560 698970000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 698970000041 CAP-like domain; other site 698970000042 active site 698970000043 primary dimer interface [polypeptide binding]; other site 698970000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698970000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698970000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698970000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698970000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698970000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698970000050 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 698970000051 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698970000052 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698970000053 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698970000054 L-lactate permease; Region: Lactate_perm; cl00701 698970000055 Cadherin repeat-like domain; Region: CA_like; cl15786 698970000056 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698970000057 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698970000058 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 698970000059 Walker A/P-loop; other site 698970000060 ATP binding site [chemical binding]; other site 698970000061 Q-loop/lid; other site 698970000062 ABC transporter signature motif; other site 698970000063 Walker B; other site 698970000064 D-loop; other site 698970000065 H-loop/switch region; other site 698970000066 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698970000067 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970000068 Walker A/P-loop; other site 698970000069 ATP binding site [chemical binding]; other site 698970000070 Q-loop/lid; other site 698970000071 ABC transporter signature motif; other site 698970000072 Walker B; other site 698970000073 D-loop; other site 698970000074 H-loop/switch region; other site 698970000075 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698970000076 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698970000077 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 698970000078 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698970000079 putative ligand binding site [chemical binding]; other site 698970000080 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698970000081 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698970000082 TM-ABC transporter signature motif; other site 698970000083 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698970000084 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698970000085 Walker A/P-loop; other site 698970000086 ATP binding site [chemical binding]; other site 698970000087 Q-loop/lid; other site 698970000088 ABC transporter signature motif; other site 698970000089 Walker B; other site 698970000090 D-loop; other site 698970000091 H-loop/switch region; other site 698970000092 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698970000093 active site 698970000094 Integrase core domain; Region: rve_2; pfam13333 698970000095 Rhomboid family; Region: Rhomboid; pfam01694 698970000096 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 698970000097 ThiC-associated domain; Region: ThiC-associated; pfam13667 698970000098 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 698970000099 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698970000100 thiamine phosphate binding site [chemical binding]; other site 698970000101 active site 698970000102 pyrophosphate binding site [ion binding]; other site 698970000103 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698970000104 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 698970000105 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 698970000106 ThiS interaction site; other site 698970000107 putative active site [active] 698970000108 tetramer interface [polypeptide binding]; other site 698970000109 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 698970000110 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698970000111 ATP binding site [chemical binding]; other site 698970000112 substrate interface [chemical binding]; other site 698970000113 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698970000114 active site residue [active] 698970000115 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 698970000116 dimer interface [polypeptide binding]; other site 698970000117 substrate binding site [chemical binding]; other site 698970000118 ATP binding site [chemical binding]; other site 698970000119 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698970000120 helicase Cas3; Provisional; Region: PRK09694 698970000121 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 698970000122 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698970000123 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 698970000124 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 698970000125 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 698970000126 CT1975-like protein; Region: Cas_CT1975; pfam09344 698970000127 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 698970000128 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 698970000129 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 698970000130 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 698970000131 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 698970000132 putative septation inhibitor protein; Reviewed; Region: PRK00159 698970000133 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698970000134 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698970000135 active site 698970000136 ATP binding site [chemical binding]; other site 698970000137 substrate binding site [chemical binding]; other site 698970000138 activation loop (A-loop); other site 698970000139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698970000140 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698970000141 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698970000142 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698970000143 PASTA domain; Region: PASTA; pfam03793 698970000144 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698970000145 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698970000146 active site 698970000147 ATP binding site [chemical binding]; other site 698970000148 substrate binding site [chemical binding]; other site 698970000149 activation loop (A-loop); other site 698970000150 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698970000151 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698970000152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698970000153 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 698970000154 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 698970000155 Protein phosphatase 2C; Region: PP2C; pfam00481 698970000156 active site 698970000157 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698970000158 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698970000159 phosphopeptide binding site; other site 698970000160 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 698970000161 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698970000162 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698970000163 phosphopeptide binding site; other site 698970000164 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698970000165 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698970000166 non-specific DNA binding site [nucleotide binding]; other site 698970000167 salt bridge; other site 698970000168 sequence-specific DNA binding site [nucleotide binding]; other site 698970000169 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 698970000170 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 698970000171 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 698970000172 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698970000173 Walker A/P-loop; other site 698970000174 ATP binding site [chemical binding]; other site 698970000175 Q-loop/lid; other site 698970000176 ABC transporter signature motif; other site 698970000177 Walker B; other site 698970000178 D-loop; other site 698970000179 H-loop/switch region; other site 698970000180 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698970000181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698970000182 active site 698970000183 phosphorylation site [posttranslational modification] 698970000184 intermolecular recognition site; other site 698970000185 dimerization interface [polypeptide binding]; other site 698970000186 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698970000187 DNA binding residues [nucleotide binding] 698970000188 dimerization interface [polypeptide binding]; other site 698970000189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698970000190 Histidine kinase; Region: HisKA_3; pfam07730 698970000191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698970000192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698970000193 dimer interface [polypeptide binding]; other site 698970000194 conserved gate region; other site 698970000195 putative PBP binding loops; other site 698970000196 ABC-ATPase subunit interface; other site 698970000197 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698970000198 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 698970000199 Walker A/P-loop; other site 698970000200 ATP binding site [chemical binding]; other site 698970000201 Q-loop/lid; other site 698970000202 ABC transporter signature motif; other site 698970000203 Walker B; other site 698970000204 D-loop; other site 698970000205 H-loop/switch region; other site 698970000206 Anti-sigma-K factor rskA; Region: RskA; pfam10099 698970000207 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 698970000208 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698970000209 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698970000210 DNA binding residues [nucleotide binding] 698970000211 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698970000212 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698970000213 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 698970000214 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698970000215 catalytic residues [active] 698970000216 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 698970000217 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698970000218 DNA binding residues [nucleotide binding] 698970000219 dimer interface [polypeptide binding]; other site 698970000220 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 698970000221 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 698970000222 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 698970000223 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 698970000224 putative metal binding site [ion binding]; other site 698970000225 biotin synthase; Validated; Region: PRK06256 698970000226 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698970000227 FeS/SAM binding site; other site 698970000228 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698970000229 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 698970000230 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 698970000231 putative ligand binding residues [chemical binding]; other site 698970000232 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698970000233 ABC-ATPase subunit interface; other site 698970000234 dimer interface [polypeptide binding]; other site 698970000235 putative PBP binding regions; other site 698970000236 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698970000237 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698970000238 Walker A/P-loop; other site 698970000239 ATP binding site [chemical binding]; other site 698970000240 Q-loop/lid; other site 698970000241 ABC transporter signature motif; other site 698970000242 Walker B; other site 698970000243 D-loop; other site 698970000244 H-loop/switch region; other site 698970000245 Uncharacterized conserved protein [Function unknown]; Region: COG5646 698970000246 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 698970000247 DNA photolyase; Region: DNA_photolyase; pfam00875 698970000248 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 698970000249 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 698970000250 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 698970000251 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 698970000252 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 698970000253 Lipase (class 2); Region: Lipase_2; pfam01674 698970000254 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 698970000255 dimer interface [polypeptide binding]; other site 698970000256 FMN binding site [chemical binding]; other site 698970000257 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698970000258 Divergent AAA domain; Region: AAA_4; pfam04326 698970000259 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698970000260 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698970000261 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 698970000262 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 698970000263 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 698970000264 trimer interface [polypeptide binding]; other site 698970000265 putative metal binding site [ion binding]; other site 698970000266 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698970000267 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 698970000268 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 698970000269 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 698970000270 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698970000271 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698970000272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 698970000273 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698970000274 MarR family; Region: MarR; pfam01047 698970000275 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 698970000276 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698970000277 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698970000278 hypothetical protein; Provisional; Region: PRK10621 698970000279 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698970000280 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 698970000281 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698970000282 ATP binding site [chemical binding]; other site 698970000283 putative Mg++ binding site [ion binding]; other site 698970000284 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698970000285 nucleotide binding region [chemical binding]; other site 698970000286 Helicase associated domain (HA2); Region: HA2; pfam04408 698970000287 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 698970000288 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 698970000289 maltose O-acetyltransferase; Provisional; Region: PRK10092 698970000290 active site 698970000291 substrate binding site [chemical binding]; other site 698970000292 trimer interface [polypeptide binding]; other site 698970000293 CoA binding site [chemical binding]; other site 698970000294 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698970000295 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 698970000296 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698970000297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698970000298 NAD(P) binding site [chemical binding]; other site 698970000299 active site 698970000300 potential frameshift: common BLAST hit: gi|336325819|ref|YP_004605785.1| transposase for insertion sequence element 698970000301 potential frameshift: common BLAST hit: gi|336325819|ref|YP_004605785.1| transposase for insertion sequence element 698970000302 Helix-turn-helix domain; Region: HTH_38; pfam13936 698970000303 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698970000304 Integrase core domain; Region: rve; pfam00665 698970000305 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698970000306 Integrase core domain; Region: rve; pfam00665 698970000307 SdpI/YhfL protein family; Region: SdpI; pfam13630 698970000308 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698970000309 RNA binding surface [nucleotide binding]; other site 698970000310 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698970000311 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698970000312 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698970000313 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 698970000314 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 698970000315 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 698970000316 active site 698970000317 Zn binding site [ion binding]; other site 698970000318 Protease prsW family; Region: PrsW-protease; pfam13367 698970000319 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698970000320 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 698970000321 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 698970000322 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 698970000323 short chain dehydrogenase; Provisional; Region: PRK07904 698970000324 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698970000325 NAD(P) binding site [chemical binding]; other site 698970000326 active site 698970000327 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698970000328 FAD binding domain; Region: FAD_binding_4; pfam01565 698970000329 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 698970000330 Predicted membrane protein [Function unknown]; Region: COG2246 698970000331 GtrA-like protein; Region: GtrA; pfam04138 698970000332 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698970000333 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698970000334 active site 698970000335 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698970000336 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698970000337 intersubunit interface [polypeptide binding]; other site 698970000338 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698970000339 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698970000340 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698970000341 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698970000342 ABC-ATPase subunit interface; other site 698970000343 dimer interface [polypeptide binding]; other site 698970000344 putative PBP binding regions; other site 698970000345 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698970000346 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698970000347 ABC-ATPase subunit interface; other site 698970000348 dimer interface [polypeptide binding]; other site 698970000349 putative PBP binding regions; other site 698970000350 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698970000351 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698970000352 intersubunit interface [polypeptide binding]; other site 698970000353 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 698970000354 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 698970000355 Walker A/P-loop; other site 698970000356 ATP binding site [chemical binding]; other site 698970000357 Q-loop/lid; other site 698970000358 ABC transporter signature motif; other site 698970000359 Walker B; other site 698970000360 D-loop; other site 698970000361 H-loop/switch region; other site 698970000362 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 698970000363 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698970000364 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698970000365 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698970000366 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698970000367 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 698970000368 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 698970000369 NAD(P) binding site [chemical binding]; other site 698970000370 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 698970000371 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698970000372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698970000373 homodimer interface [polypeptide binding]; other site 698970000374 catalytic residue [active] 698970000375 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 698970000376 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 698970000377 transmembrane helices; other site 698970000378 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698970000379 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 698970000380 NodB motif; other site 698970000381 active site 698970000382 catalytic site [active] 698970000383 metal binding site [ion binding]; metal-binding site 698970000384 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698970000385 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698970000386 DNA-binding site [nucleotide binding]; DNA binding site 698970000387 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698970000388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698970000389 homodimer interface [polypeptide binding]; other site 698970000390 catalytic residue [active] 698970000391 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 698970000392 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 698970000393 active site 698970000394 multimer interface [polypeptide binding]; other site 698970000395 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 698970000396 predicted active site [active] 698970000397 catalytic triad [active] 698970000398 potential frameshift: common BLAST hit: gi|68535552|ref|YP_250257.1| transposase IS3510c 698970000399 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698970000400 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698970000401 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698970000402 active site 698970000403 catalytic site [active] 698970000404 Cna protein B-type domain; Region: Cna_B; pfam05738 698970000405 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698970000406 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698970000407 active site 698970000408 catalytic site [active] 698970000409 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698970000410 metal ion-dependent adhesion site (MIDAS); other site 698970000411 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 698970000412 prephenate dehydrogenase; Validated; Region: PRK08507 698970000413 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 698970000414 nucleoside/Zn binding site; other site 698970000415 dimer interface [polypeptide binding]; other site 698970000416 catalytic motif [active] 698970000417 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698970000418 active site 698970000419 Int/Topo IB signature motif; other site 698970000420 DNA binding site [nucleotide binding] 698970000421 Helix-turn-helix domain; Region: HTH_17; pfam12728 698970000422 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 698970000423 DNA binding residues [nucleotide binding] 698970000424 PIN domain; Region: PIN_3; pfam13470 698970000425 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 698970000426 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 698970000427 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 698970000428 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 698970000429 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 698970000430 active site 698970000431 HIGH motif; other site 698970000432 nucleotide binding site [chemical binding]; other site 698970000433 active site 698970000434 KMSKS motif; other site 698970000435 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 698970000436 fructuronate transporter; Provisional; Region: PRK10034; cl15264 698970000437 Shikimate kinase; Region: SKI; pfam01202 698970000438 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 698970000439 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 698970000440 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 698970000441 putative NAD(P) binding site [chemical binding]; other site 698970000442 catalytic Zn binding site [ion binding]; other site 698970000443 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 698970000444 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 698970000445 NADP binding site [chemical binding]; other site 698970000446 homodimer interface [polypeptide binding]; other site 698970000447 active site 698970000448 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 698970000449 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698970000450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698970000451 homodimer interface [polypeptide binding]; other site 698970000452 catalytic residue [active] 698970000453 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 698970000454 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 698970000455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698970000456 Walker A motif; other site 698970000457 ATP binding site [chemical binding]; other site 698970000458 Walker B motif; other site 698970000459 arginine finger; other site 698970000460 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 698970000461 hypothetical protein; Validated; Region: PRK00153 698970000462 recombination protein RecR; Reviewed; Region: recR; PRK00076 698970000463 RecR protein; Region: RecR; pfam02132 698970000464 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 698970000465 putative active site [active] 698970000466 putative metal-binding site [ion binding]; other site 698970000467 tetramer interface [polypeptide binding]; other site 698970000468 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698970000469 catalytic triad [active] 698970000470 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 698970000471 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698970000472 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 698970000473 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 698970000474 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698970000475 active site 698970000476 catalytic site [active] 698970000477 substrate binding site [chemical binding]; other site 698970000478 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 698970000479 dimer interface [polypeptide binding]; other site 698970000480 FMN binding site [chemical binding]; other site 698970000481 NADPH bind site [chemical binding]; other site 698970000482 2-isopropylmalate synthase; Validated; Region: PRK03739 698970000483 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 698970000484 active site 698970000485 catalytic residues [active] 698970000486 metal binding site [ion binding]; metal-binding site 698970000487 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 698970000488 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698970000489 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698970000490 DNA binding residues [nucleotide binding] 698970000491 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698970000492 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698970000493 active site 698970000494 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 698970000495 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698970000496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970000497 putative substrate translocation pore; other site 698970000498 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 698970000499 intersubunit interface [polypeptide binding]; other site 698970000500 active site 698970000501 catalytic residue [active] 698970000502 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 698970000503 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 698970000504 active site 698970000505 substrate binding site [chemical binding]; other site 698970000506 metal binding site [ion binding]; metal-binding site 698970000507 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 698970000508 aspartate kinase; Reviewed; Region: PRK06635 698970000509 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 698970000510 putative nucleotide binding site [chemical binding]; other site 698970000511 putative catalytic residues [active] 698970000512 putative Mg ion binding site [ion binding]; other site 698970000513 putative aspartate binding site [chemical binding]; other site 698970000514 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 698970000515 putative allosteric regulatory site; other site 698970000516 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 698970000517 putative allosteric regulatory residue; other site 698970000518 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 698970000519 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698970000520 RNA polymerase sigma factor; Provisional; Region: PRK12535 698970000521 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698970000522 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698970000523 DNA binding residues [nucleotide binding] 698970000524 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 698970000525 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 698970000526 heme binding pocket [chemical binding]; other site 698970000527 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698970000528 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 698970000529 Walker A/P-loop; other site 698970000530 ATP binding site [chemical binding]; other site 698970000531 Q-loop/lid; other site 698970000532 ABC transporter signature motif; other site 698970000533 Walker B; other site 698970000534 D-loop; other site 698970000535 H-loop/switch region; other site 698970000536 TOBE domain; Region: TOBE_2; pfam08402 698970000537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698970000538 dimer interface [polypeptide binding]; other site 698970000539 conserved gate region; other site 698970000540 ABC-ATPase subunit interface; other site 698970000541 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698970000542 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 698970000543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970000544 putative substrate translocation pore; other site 698970000545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970000546 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698970000547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698970000548 active site 698970000549 phosphorylation site [posttranslational modification] 698970000550 intermolecular recognition site; other site 698970000551 dimerization interface [polypeptide binding]; other site 698970000552 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698970000553 DNA binding site [nucleotide binding] 698970000554 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698970000555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698970000556 dimer interface [polypeptide binding]; other site 698970000557 phosphorylation site [posttranslational modification] 698970000558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698970000559 ATP binding site [chemical binding]; other site 698970000560 Mg2+ binding site [ion binding]; other site 698970000561 G-X-G motif; other site 698970000562 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 698970000563 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 698970000564 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 698970000565 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 698970000566 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698970000567 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 698970000568 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 698970000569 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698970000570 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 698970000571 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698970000572 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698970000573 Predicted membrane protein [Function unknown]; Region: COG1511 698970000574 Predicted membrane protein [Function unknown]; Region: COG1511 698970000575 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698970000576 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698970000577 putative active site [active] 698970000578 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 698970000579 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698970000580 putative active site [active] 698970000581 putative metal binding site [ion binding]; other site 698970000582 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698970000583 Transglycosylase; Region: Transgly; pfam00912 698970000584 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698970000585 PASTA domain; Region: PASTA; pfam03793 698970000586 Transcription factor WhiB; Region: Whib; pfam02467 698970000587 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 698970000588 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 698970000589 homotrimer interaction site [polypeptide binding]; other site 698970000590 putative active site [active] 698970000591 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698970000592 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698970000593 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698970000594 ligand binding site [chemical binding]; other site 698970000595 flexible hinge region; other site 698970000596 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698970000597 putative switch regulator; other site 698970000598 non-specific DNA interactions [nucleotide binding]; other site 698970000599 DNA binding site [nucleotide binding] 698970000600 sequence specific DNA binding site [nucleotide binding]; other site 698970000601 putative cAMP binding site [chemical binding]; other site 698970000602 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 698970000603 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698970000604 minor groove reading motif; other site 698970000605 helix-hairpin-helix signature motif; other site 698970000606 substrate binding pocket [chemical binding]; other site 698970000607 active site 698970000608 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 698970000609 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698970000610 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698970000611 catalytic residues [active] 698970000612 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 698970000613 putative active site [active] 698970000614 putative CoA binding site [chemical binding]; other site 698970000615 nudix motif; other site 698970000616 metal binding site [ion binding]; metal-binding site 698970000617 Colicin V production protein; Region: Colicin_V; pfam02674 698970000618 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 698970000619 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698970000620 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698970000621 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698970000622 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 698970000623 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698970000624 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698970000625 motif II; other site 698970000626 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 698970000627 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 698970000628 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 698970000629 ATP binding site [chemical binding]; other site 698970000630 Walker A motif; other site 698970000631 hexamer interface [polypeptide binding]; other site 698970000632 Walker B motif; other site 698970000633 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 698970000634 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 698970000635 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 698970000636 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698970000637 ATP binding site [chemical binding]; other site 698970000638 putative Mg++ binding site [ion binding]; other site 698970000639 nucleotide binding region [chemical binding]; other site 698970000640 helicase superfamily c-terminal domain; Region: HELICc; smart00490 698970000641 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 698970000642 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698970000643 DNA-binding site [nucleotide binding]; DNA binding site 698970000644 RNA-binding motif; other site 698970000645 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698970000646 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698970000647 Walker A/P-loop; other site 698970000648 ATP binding site [chemical binding]; other site 698970000649 Q-loop/lid; other site 698970000650 ABC transporter signature motif; other site 698970000651 Walker B; other site 698970000652 D-loop; other site 698970000653 H-loop/switch region; other site 698970000654 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698970000655 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698970000656 Walker A/P-loop; other site 698970000657 ATP binding site [chemical binding]; other site 698970000658 Q-loop/lid; other site 698970000659 ABC transporter signature motif; other site 698970000660 Walker B; other site 698970000661 D-loop; other site 698970000662 H-loop/switch region; other site 698970000663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970000664 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698970000665 putative substrate translocation pore; other site 698970000666 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698970000667 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 698970000668 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698970000669 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 698970000670 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698970000671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698970000672 dimer interface [polypeptide binding]; other site 698970000673 conserved gate region; other site 698970000674 putative PBP binding loops; other site 698970000675 ABC-ATPase subunit interface; other site 698970000676 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698970000677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698970000678 NAD(P) binding site [chemical binding]; other site 698970000679 active site 698970000680 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 698970000681 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 698970000682 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 698970000683 active site 698970000684 interdomain interaction site; other site 698970000685 putative metal-binding site [ion binding]; other site 698970000686 nucleotide binding site [chemical binding]; other site 698970000687 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 698970000688 domain I; other site 698970000689 DNA binding groove [nucleotide binding] 698970000690 phosphate binding site [ion binding]; other site 698970000691 domain II; other site 698970000692 domain III; other site 698970000693 nucleotide binding site [chemical binding]; other site 698970000694 catalytic site [active] 698970000695 domain IV; other site 698970000696 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 698970000697 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698970000698 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698970000699 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698970000700 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698970000701 active site 698970000702 Predicted membrane protein [Function unknown]; Region: COG1297 698970000703 putative oligopeptide transporter, OPT family; Region: TIGR00733 698970000704 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 698970000705 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698970000706 catalytic site [active] 698970000707 Asp-box motif; other site 698970000708 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698970000709 dimerization interface [polypeptide binding]; other site 698970000710 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698970000711 cyclase homology domain; Region: CHD; cd07302 698970000712 nucleotidyl binding site; other site 698970000713 metal binding site [ion binding]; metal-binding site 698970000714 dimer interface [polypeptide binding]; other site 698970000715 DNA polymerase III subunit delta'; Validated; Region: PRK07940 698970000716 DNA polymerase III subunit delta'; Validated; Region: PRK08485 698970000717 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 698970000718 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 698970000719 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698970000720 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 698970000721 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698970000722 DNA binding site [nucleotide binding] 698970000723 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 698970000724 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 698970000725 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698970000726 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698970000727 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698970000728 Fic family protein [Function unknown]; Region: COG3177 698970000729 Fic/DOC family; Region: Fic; pfam02661 698970000730 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698970000731 Trypsin; Region: Trypsin; pfam00089 698970000732 active site 698970000733 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 698970000734 putative DNA binding site [nucleotide binding]; other site 698970000735 putative Zn2+ binding site [ion binding]; other site 698970000736 potential frameshift: common BLAST hit: gi|227832949|ref|YP_002834656.1| transposase 698970000737 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698970000738 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698970000739 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698970000740 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 698970000741 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698970000742 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698970000743 active site 698970000744 catalytic site [active] 698970000745 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 698970000746 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 698970000747 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 698970000748 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 698970000749 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 698970000750 Ca binding site [ion binding]; other site 698970000751 active site 698970000752 catalytic site [active] 698970000753 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 698970000754 acyl-CoA synthetase; Validated; Region: PRK07788 698970000755 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698970000756 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698970000757 acyl-activating enzyme (AAE) consensus motif; other site 698970000758 acyl-activating enzyme (AAE) consensus motif; other site 698970000759 AMP binding site [chemical binding]; other site 698970000760 active site 698970000761 CoA binding site [chemical binding]; other site 698970000762 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 698970000763 active site 698970000764 catalytic triad [active] 698970000765 oxyanion hole [active] 698970000766 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 698970000767 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 698970000768 substrate binding site; other site 698970000769 tetramer interface; other site 698970000770 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 698970000771 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 698970000772 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 698970000773 NADP binding site [chemical binding]; other site 698970000774 active site 698970000775 putative substrate binding site [chemical binding]; other site 698970000776 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 698970000777 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 698970000778 NAD binding site [chemical binding]; other site 698970000779 substrate binding site [chemical binding]; other site 698970000780 homodimer interface [polypeptide binding]; other site 698970000781 active site 698970000782 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 698970000783 Zn binding site [ion binding]; other site 698970000784 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 698970000785 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698970000786 Putative esterase; Region: Esterase; pfam00756 698970000787 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 698970000788 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 698970000789 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698970000790 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698970000791 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698970000792 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698970000793 non-specific DNA binding site [nucleotide binding]; other site 698970000794 salt bridge; other site 698970000795 sequence-specific DNA binding site [nucleotide binding]; other site 698970000796 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 698970000797 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698970000798 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 698970000799 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 698970000800 putative Iron-sulfur protein interface [polypeptide binding]; other site 698970000801 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 698970000802 proximal heme binding site [chemical binding]; other site 698970000803 distal heme binding site [chemical binding]; other site 698970000804 putative dimer interface [polypeptide binding]; other site 698970000805 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 698970000806 L-aspartate oxidase; Provisional; Region: PRK06175 698970000807 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 698970000808 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 698970000809 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 698970000810 Predicted membrane protein [Function unknown]; Region: COG2733 698970000811 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 698970000812 Class I aldolases; Region: Aldolase_Class_I; cd00945 698970000813 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698970000814 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 698970000815 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698970000816 FeS/SAM binding site; other site 698970000817 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 698970000818 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698970000819 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 698970000820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698970000821 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 698970000822 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 698970000823 FAD binding domain; Region: FAD_binding_4; pfam01565 698970000824 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 698970000825 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 698970000826 pentamer interface [polypeptide binding]; other site 698970000827 dodecaamer interface [polypeptide binding]; other site 698970000828 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698970000829 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698970000830 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698970000831 acyl-activating enzyme (AAE) consensus motif; other site 698970000832 AMP binding site [chemical binding]; other site 698970000833 active site 698970000834 CoA binding site [chemical binding]; other site 698970000835 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698970000836 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 698970000837 acyl-activating enzyme (AAE) consensus motif; other site 698970000838 putative AMP binding site [chemical binding]; other site 698970000839 putative active site [active] 698970000840 putative CoA binding site [chemical binding]; other site 698970000841 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 698970000842 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 698970000843 putative ADP-binding pocket [chemical binding]; other site 698970000844 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698970000845 catalytic core [active] 698970000846 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698970000847 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698970000848 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698970000849 dimer interface [polypeptide binding]; other site 698970000850 phosphorylation site [posttranslational modification] 698970000851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698970000852 ATP binding site [chemical binding]; other site 698970000853 Mg2+ binding site [ion binding]; other site 698970000854 G-X-G motif; other site 698970000855 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698970000856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698970000857 active site 698970000858 phosphorylation site [posttranslational modification] 698970000859 intermolecular recognition site; other site 698970000860 dimerization interface [polypeptide binding]; other site 698970000861 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698970000862 DNA binding site [nucleotide binding] 698970000863 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698970000864 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 698970000865 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 698970000866 DNA binding domain, excisionase family; Region: excise; TIGR01764 698970000867 Thioredoxin; Region: Thioredoxin_4; cl17273 698970000868 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698970000869 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698970000870 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 698970000871 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698970000872 motif II; other site 698970000873 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 698970000874 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 698970000875 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 698970000876 tRNA; other site 698970000877 putative tRNA binding site [nucleotide binding]; other site 698970000878 putative NADP binding site [chemical binding]; other site 698970000879 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 698970000880 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 698970000881 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 698970000882 domain interfaces; other site 698970000883 active site 698970000884 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 698970000885 active site 698970000886 homodimer interface [polypeptide binding]; other site 698970000887 SAM binding site [chemical binding]; other site 698970000888 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 698970000889 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 698970000890 active site 698970000891 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 698970000892 dimer interface [polypeptide binding]; other site 698970000893 active site 698970000894 Schiff base residues; other site 698970000895 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 698970000896 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698970000897 Predicted membrane protein [Function unknown]; Region: COG2311 698970000898 Protein of unknown function (DUF418); Region: DUF418; pfam04235 698970000899 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 698970000900 substrate binding site [chemical binding]; other site 698970000901 active site 698970000902 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 698970000903 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 698970000904 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698970000905 inhibitor-cofactor binding pocket; inhibition site 698970000906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698970000907 catalytic residue [active] 698970000908 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698970000909 catalytic core [active] 698970000910 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698970000911 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698970000912 catalytic residues [active] 698970000913 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698970000914 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698970000915 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 698970000916 ResB-like family; Region: ResB; pfam05140 698970000917 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 698970000918 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698970000919 dimerization interface [polypeptide binding]; other site 698970000920 putative DNA binding site [nucleotide binding]; other site 698970000921 putative Zn2+ binding site [ion binding]; other site 698970000922 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 698970000923 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 698970000924 UbiA prenyltransferase family; Region: UbiA; pfam01040 698970000925 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698970000926 active site 698970000927 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698970000928 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 698970000929 acyl-activating enzyme (AAE) consensus motif; other site 698970000930 AMP binding site [chemical binding]; other site 698970000931 active site 698970000932 CoA binding site [chemical binding]; other site 698970000933 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 698970000934 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698970000935 substrate binding site [chemical binding]; other site 698970000936 oxyanion hole (OAH) forming residues; other site 698970000937 trimer interface [polypeptide binding]; other site 698970000938 O-succinylbenzoate synthase; Provisional; Region: PRK02901 698970000939 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 698970000940 active site 698970000941 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 698970000942 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 698970000943 dimer interface [polypeptide binding]; other site 698970000944 tetramer interface [polypeptide binding]; other site 698970000945 PYR/PP interface [polypeptide binding]; other site 698970000946 TPP binding site [chemical binding]; other site 698970000947 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 698970000948 TPP-binding site; other site 698970000949 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 698970000950 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698970000951 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 698970000952 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 698970000953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698970000954 S-adenosylmethionine binding site [chemical binding]; other site 698970000955 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 698970000956 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 698970000957 NAD binding site [chemical binding]; other site 698970000958 dimer interface [polypeptide binding]; other site 698970000959 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698970000960 substrate binding site [chemical binding]; other site 698970000961 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 698970000962 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698970000963 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698970000964 substrate binding pocket [chemical binding]; other site 698970000965 chain length determination region; other site 698970000966 substrate-Mg2+ binding site; other site 698970000967 catalytic residues [active] 698970000968 aspartate-rich region 1; other site 698970000969 active site lid residues [active] 698970000970 aspartate-rich region 2; other site 698970000971 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 698970000972 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 698970000973 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 698970000974 putative homodimer interface [polypeptide binding]; other site 698970000975 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 698970000976 heterodimer interface [polypeptide binding]; other site 698970000977 homodimer interface [polypeptide binding]; other site 698970000978 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 698970000979 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 698970000980 23S rRNA interface [nucleotide binding]; other site 698970000981 L7/L12 interface [polypeptide binding]; other site 698970000982 putative thiostrepton binding site; other site 698970000983 L25 interface [polypeptide binding]; other site 698970000984 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 698970000985 mRNA/rRNA interface [nucleotide binding]; other site 698970000986 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 698970000987 23S rRNA interface [nucleotide binding]; other site 698970000988 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 698970000989 50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157 698970000990 L11 interface [polypeptide binding]; other site 698970000991 putative EF-Tu interaction site [polypeptide binding]; other site 698970000992 putative EF-G interaction site [polypeptide binding]; other site 698970000993 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 698970000994 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698970000995 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698970000996 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698970000997 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698970000998 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698970000999 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 698970001000 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698970001001 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698970001002 ABC-ATPase subunit interface; other site 698970001003 dimer interface [polypeptide binding]; other site 698970001004 putative PBP binding regions; other site 698970001005 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698970001006 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698970001007 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698970001008 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698970001009 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 698970001010 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 698970001011 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 698970001012 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 698970001013 RPB1 interaction site [polypeptide binding]; other site 698970001014 RPB10 interaction site [polypeptide binding]; other site 698970001015 RPB11 interaction site [polypeptide binding]; other site 698970001016 RPB3 interaction site [polypeptide binding]; other site 698970001017 RPB12 interaction site [polypeptide binding]; other site 698970001018 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 698970001019 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 698970001020 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 698970001021 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 698970001022 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 698970001023 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698970001024 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 698970001025 G-loop; other site 698970001026 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698970001027 DNA binding site [nucleotide binding] 698970001028 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 698970001029 Transposase; Region: DDE_Tnp_ISL3; pfam01610 698970001030 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698970001031 Histidine kinase; Region: HisKA_3; pfam07730 698970001032 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698970001033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698970001034 active site 698970001035 phosphorylation site [posttranslational modification] 698970001036 intermolecular recognition site; other site 698970001037 dimerization interface [polypeptide binding]; other site 698970001038 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698970001039 DNA binding residues [nucleotide binding] 698970001040 dimerization interface [polypeptide binding]; other site 698970001041 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698970001042 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698970001043 Walker A/P-loop; other site 698970001044 ATP binding site [chemical binding]; other site 698970001045 Q-loop/lid; other site 698970001046 ABC transporter signature motif; other site 698970001047 Walker B; other site 698970001048 D-loop; other site 698970001049 H-loop/switch region; other site 698970001050 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 698970001051 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 698970001052 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698970001053 TIGR03943 family protein; Region: TIGR03943 698970001054 Predicted permeases [General function prediction only]; Region: COG0701 698970001055 Radical SAM superfamily; Region: Radical_SAM; pfam04055 698970001056 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698970001057 FeS/SAM binding site; other site 698970001058 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 698970001059 Class III ribonucleotide reductase; Region: RNR_III; cd01675 698970001060 effector binding site; other site 698970001061 active site 698970001062 Zn binding site [ion binding]; other site 698970001063 glycine loop; other site 698970001064 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 698970001065 S17 interaction site [polypeptide binding]; other site 698970001066 S8 interaction site; other site 698970001067 16S rRNA interaction site [nucleotide binding]; other site 698970001068 streptomycin interaction site [chemical binding]; other site 698970001069 23S rRNA interaction site [nucleotide binding]; other site 698970001070 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 698970001071 30S ribosomal protein S7; Validated; Region: PRK05302 698970001072 elongation factor G; Reviewed; Region: PRK00007 698970001073 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 698970001074 G1 box; other site 698970001075 putative GEF interaction site [polypeptide binding]; other site 698970001076 GTP/Mg2+ binding site [chemical binding]; other site 698970001077 Switch I region; other site 698970001078 G2 box; other site 698970001079 G3 box; other site 698970001080 Switch II region; other site 698970001081 G4 box; other site 698970001082 G5 box; other site 698970001083 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 698970001084 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 698970001085 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 698970001086 elongation factor Tu; Reviewed; Region: PRK00049 698970001087 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 698970001088 G1 box; other site 698970001089 GEF interaction site [polypeptide binding]; other site 698970001090 GTP/Mg2+ binding site [chemical binding]; other site 698970001091 Switch I region; other site 698970001092 G2 box; other site 698970001093 G3 box; other site 698970001094 Switch II region; other site 698970001095 G4 box; other site 698970001096 G5 box; other site 698970001097 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 698970001098 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 698970001099 Antibiotic Binding Site [chemical binding]; other site 698970001100 Predicted membrane protein [Function unknown]; Region: COG2323 698970001101 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 698970001102 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 698970001103 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 698970001104 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 698970001105 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 698970001106 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 698970001107 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 698970001108 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 698970001109 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 698970001110 putative translocon binding site; other site 698970001111 protein-rRNA interface [nucleotide binding]; other site 698970001112 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 698970001113 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 698970001114 G-X-X-G motif; other site 698970001115 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 698970001116 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 698970001117 23S rRNA interface [nucleotide binding]; other site 698970001118 5S rRNA interface [nucleotide binding]; other site 698970001119 putative antibiotic binding site [chemical binding]; other site 698970001120 L25 interface [polypeptide binding]; other site 698970001121 L27 interface [polypeptide binding]; other site 698970001122 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 698970001123 putative translocon interaction site; other site 698970001124 23S rRNA interface [nucleotide binding]; other site 698970001125 signal recognition particle (SRP54) interaction site; other site 698970001126 L23 interface [polypeptide binding]; other site 698970001127 trigger factor interaction site; other site 698970001128 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 698970001129 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698970001130 HlyD family secretion protein; Region: HlyD_3; pfam13437 698970001131 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698970001132 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698970001133 Walker A/P-loop; other site 698970001134 ATP binding site [chemical binding]; other site 698970001135 Q-loop/lid; other site 698970001136 ABC transporter signature motif; other site 698970001137 Walker B; other site 698970001138 D-loop; other site 698970001139 H-loop/switch region; other site 698970001140 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698970001141 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698970001142 FtsX-like permease family; Region: FtsX; pfam02687 698970001143 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 698970001144 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 698970001145 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 698970001146 RNA binding site [nucleotide binding]; other site 698970001147 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 698970001148 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 698970001149 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 698970001150 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 698970001151 serine transporter; Region: stp; TIGR00814 698970001152 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698970001153 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698970001154 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698970001155 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698970001156 active site 698970001157 homotetramer interface [polypeptide binding]; other site 698970001158 homodimer interface [polypeptide binding]; other site 698970001159 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 698970001160 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698970001161 ATP binding site [chemical binding]; other site 698970001162 substrate interface [chemical binding]; other site 698970001163 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698970001164 active site residue [active] 698970001165 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698970001166 MPT binding site; other site 698970001167 trimer interface [polypeptide binding]; other site 698970001168 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 698970001169 MoaE homodimer interface [polypeptide binding]; other site 698970001170 MoaD interaction [polypeptide binding]; other site 698970001171 active site residues [active] 698970001172 Predicted transcriptional regulator [Transcription]; Region: COG2345 698970001173 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 698970001174 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698970001175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698970001176 dimer interface [polypeptide binding]; other site 698970001177 conserved gate region; other site 698970001178 putative PBP binding loops; other site 698970001179 ABC-ATPase subunit interface; other site 698970001180 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970001181 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 698970001182 Walker A/P-loop; other site 698970001183 ATP binding site [chemical binding]; other site 698970001184 Q-loop/lid; other site 698970001185 ABC transporter signature motif; other site 698970001186 Walker B; other site 698970001187 D-loop; other site 698970001188 H-loop/switch region; other site 698970001189 TOBE domain; Region: TOBE; cl01440 698970001190 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 698970001191 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698970001192 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 698970001193 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 698970001194 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 698970001195 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 698970001196 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 698970001197 [4Fe-4S] binding site [ion binding]; other site 698970001198 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698970001199 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698970001200 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698970001201 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 698970001202 molybdopterin cofactor binding site; other site 698970001203 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 698970001204 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 698970001205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970001206 putative substrate translocation pore; other site 698970001207 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698970001208 MPT binding site; other site 698970001209 trimer interface [polypeptide binding]; other site 698970001210 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 698970001211 GTP binding site; other site 698970001212 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 698970001213 trimer interface [polypeptide binding]; other site 698970001214 dimer interface [polypeptide binding]; other site 698970001215 putative active site [active] 698970001216 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698970001217 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698970001218 dimer interface [polypeptide binding]; other site 698970001219 putative functional site; other site 698970001220 putative MPT binding site; other site 698970001221 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 698970001222 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698970001223 FeS/SAM binding site; other site 698970001224 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 698970001225 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698970001226 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698970001227 inhibitor site; inhibition site 698970001228 active site 698970001229 dimer interface [polypeptide binding]; other site 698970001230 catalytic residue [active] 698970001231 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698970001232 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698970001233 Walker A/P-loop; other site 698970001234 ATP binding site [chemical binding]; other site 698970001235 Q-loop/lid; other site 698970001236 ABC transporter signature motif; other site 698970001237 Walker B; other site 698970001238 D-loop; other site 698970001239 H-loop/switch region; other site 698970001240 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698970001241 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698970001242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698970001243 dimer interface [polypeptide binding]; other site 698970001244 conserved gate region; other site 698970001245 putative PBP binding loops; other site 698970001246 ABC-ATPase subunit interface; other site 698970001247 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698970001248 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698970001249 Walker A/P-loop; other site 698970001250 ATP binding site [chemical binding]; other site 698970001251 Q-loop/lid; other site 698970001252 ABC transporter signature motif; other site 698970001253 Walker B; other site 698970001254 D-loop; other site 698970001255 H-loop/switch region; other site 698970001256 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698970001257 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698970001258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698970001259 dimer interface [polypeptide binding]; other site 698970001260 conserved gate region; other site 698970001261 putative PBP binding loops; other site 698970001262 ABC-ATPase subunit interface; other site 698970001263 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 698970001264 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698970001265 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698970001266 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698970001267 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698970001268 DNA-binding site [nucleotide binding]; DNA binding site 698970001269 FCD domain; Region: FCD; pfam07729 698970001270 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698970001271 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698970001272 nucleotide binding site [chemical binding]; other site 698970001273 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 698970001274 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 698970001275 putative active site cavity [active] 698970001276 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 698970001277 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 698970001278 active site 698970001279 dimer interface [polypeptide binding]; other site 698970001280 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698970001281 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 698970001282 active site 698970001283 trimer interface [polypeptide binding]; other site 698970001284 allosteric site; other site 698970001285 active site lid [active] 698970001286 hexamer (dimer of trimers) interface [polypeptide binding]; other site 698970001287 Htaa; Region: HtaA; pfam04213 698970001288 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 698970001289 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 698970001290 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698970001291 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698970001292 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 698970001293 5S rRNA interface [nucleotide binding]; other site 698970001294 L27 interface [polypeptide binding]; other site 698970001295 23S rRNA interface [nucleotide binding]; other site 698970001296 L5 interface [polypeptide binding]; other site 698970001297 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 698970001298 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 698970001299 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 698970001300 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 698970001301 23S rRNA binding site [nucleotide binding]; other site 698970001302 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 698970001303 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 698970001304 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 698970001305 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 698970001306 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698970001307 active site 698970001308 catalytic site [active] 698970001309 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698970001310 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698970001311 active site 698970001312 catalytic site [active] 698970001313 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 698970001314 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698970001315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698970001316 dimer interface [polypeptide binding]; other site 698970001317 conserved gate region; other site 698970001318 putative PBP binding loops; other site 698970001319 ABC-ATPase subunit interface; other site 698970001320 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698970001321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698970001322 dimer interface [polypeptide binding]; other site 698970001323 conserved gate region; other site 698970001324 putative PBP binding loops; other site 698970001325 ABC-ATPase subunit interface; other site 698970001326 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 698970001327 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698970001328 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698970001329 Walker A/P-loop; other site 698970001330 ATP binding site [chemical binding]; other site 698970001331 Q-loop/lid; other site 698970001332 ABC transporter signature motif; other site 698970001333 Walker B; other site 698970001334 D-loop; other site 698970001335 H-loop/switch region; other site 698970001336 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 698970001337 SecY translocase; Region: SecY; pfam00344 698970001338 adenylate kinase; Reviewed; Region: adk; PRK00279 698970001339 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 698970001340 AMP-binding site [chemical binding]; other site 698970001341 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 698970001342 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698970001343 active site 698970001344 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698970001345 catalytic site [active] 698970001346 BNR repeat-like domain; Region: BNR_2; pfam13088 698970001347 Asp-box motif; other site 698970001348 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698970001349 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 698970001350 rRNA binding site [nucleotide binding]; other site 698970001351 predicted 30S ribosome binding site; other site 698970001352 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 698970001353 30S ribosomal protein S13; Region: bact_S13; TIGR03631 698970001354 30S ribosomal protein S11; Validated; Region: PRK05309 698970001355 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 698970001356 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 698970001357 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698970001358 RNA binding surface [nucleotide binding]; other site 698970001359 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 698970001360 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 698970001361 alphaNTD - beta interaction site [polypeptide binding]; other site 698970001362 alphaNTD homodimer interface [polypeptide binding]; other site 698970001363 alphaNTD - beta' interaction site [polypeptide binding]; other site 698970001364 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 698970001365 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 698970001366 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 698970001367 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 698970001368 dimerization interface 3.5A [polypeptide binding]; other site 698970001369 active site 698970001370 Protein of unknown function (DUF690); Region: DUF690; cl04939 698970001371 TIGR02611 family protein; Region: TIGR02611 698970001372 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 698970001373 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 698970001374 active site 698970001375 catalytic residues [active] 698970001376 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 698970001377 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 698970001378 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698970001379 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 698970001380 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698970001381 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698970001382 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 698970001383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 698970001384 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 698970001385 Integrase core domain; Region: rve; pfam00665 698970001386 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 698970001387 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 698970001388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 698970001389 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 698970001390 23S rRNA interface [nucleotide binding]; other site 698970001391 L3 interface [polypeptide binding]; other site 698970001392 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 698970001393 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 698970001394 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 698970001395 active site 698970001396 substrate binding site [chemical binding]; other site 698970001397 metal binding site [ion binding]; metal-binding site 698970001398 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 698970001399 alanine racemase; Reviewed; Region: alr; PRK00053 698970001400 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 698970001401 active site 698970001402 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698970001403 dimer interface [polypeptide binding]; other site 698970001404 substrate binding site [chemical binding]; other site 698970001405 catalytic residues [active] 698970001406 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 698970001407 Predicted permease [General function prediction only]; Region: COG2985 698970001408 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698970001409 TrkA-C domain; Region: TrkA_C; pfam02080 698970001410 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698970001411 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698970001412 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 698970001413 Glycoprotease family; Region: Peptidase_M22; pfam00814 698970001414 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698970001415 Coenzyme A binding pocket [chemical binding]; other site 698970001416 UGMP family protein; Validated; Region: PRK09604 698970001417 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 698970001418 oligomerisation interface [polypeptide binding]; other site 698970001419 mobile loop; other site 698970001420 roof hairpin; other site 698970001421 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698970001422 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698970001423 ring oligomerisation interface [polypeptide binding]; other site 698970001424 ATP/Mg binding site [chemical binding]; other site 698970001425 stacking interactions; other site 698970001426 hinge regions; other site 698970001427 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 698970001428 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698970001429 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698970001430 DNA binding residues [nucleotide binding] 698970001431 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 698970001432 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698970001433 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 698970001434 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 698970001435 active site 698970001436 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 698970001437 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698970001438 phosphate binding site [ion binding]; other site 698970001439 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698970001440 siderophore binding site; other site 698970001441 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698970001442 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698970001443 dimer interface [polypeptide binding]; other site 698970001444 putative PBP binding regions; other site 698970001445 ABC-ATPase subunit interface; other site 698970001446 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698970001447 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698970001448 ABC-ATPase subunit interface; other site 698970001449 dimer interface [polypeptide binding]; other site 698970001450 putative PBP binding regions; other site 698970001451 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698970001452 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698970001453 Walker A/P-loop; other site 698970001454 ATP binding site [chemical binding]; other site 698970001455 Q-loop/lid; other site 698970001456 ABC transporter signature motif; other site 698970001457 Walker B; other site 698970001458 D-loop; other site 698970001459 H-loop/switch region; other site 698970001460 IucA / IucC family; Region: IucA_IucC; pfam04183 698970001461 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698970001462 IucA / IucC family; Region: IucA_IucC; pfam04183 698970001463 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698970001464 H+ Antiporter protein; Region: 2A0121; TIGR00900 698970001465 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 698970001466 EamA-like transporter family; Region: EamA; pfam00892 698970001467 GMP synthase; Reviewed; Region: guaA; PRK00074 698970001468 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 698970001469 AMP/PPi binding site [chemical binding]; other site 698970001470 candidate oxyanion hole; other site 698970001471 catalytic triad [active] 698970001472 potential glutamine specificity residues [chemical binding]; other site 698970001473 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 698970001474 ATP Binding subdomain [chemical binding]; other site 698970001475 Ligand Binding sites [chemical binding]; other site 698970001476 Dimerization subdomain; other site 698970001477 PspC domain; Region: PspC; pfam04024 698970001478 PspC domain; Region: PspC; pfam04024 698970001479 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698970001480 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698970001481 ATP binding site [chemical binding]; other site 698970001482 Mg2+ binding site [ion binding]; other site 698970001483 G-X-G motif; other site 698970001484 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698970001485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698970001486 active site 698970001487 phosphorylation site [posttranslational modification] 698970001488 intermolecular recognition site; other site 698970001489 dimerization interface [polypeptide binding]; other site 698970001490 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698970001491 DNA binding residues [nucleotide binding] 698970001492 dimerization interface [polypeptide binding]; other site 698970001493 potential frameshift: common BLAST hit: gi|38233680|ref|NP_939447.1| iron transport system exported solute-binding component 698970001494 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698970001495 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698970001496 DNA Polymerase Y-family; Region: PolY_like; cd03468 698970001497 active site 698970001498 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 698970001499 DNA binding site [nucleotide binding] 698970001500 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 698970001501 putative dimer interface [polypeptide binding]; other site 698970001502 putative [2Fe-2S] cluster binding site [ion binding]; other site 698970001503 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698970001504 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698970001505 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698970001506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698970001507 dimer interface [polypeptide binding]; other site 698970001508 conserved gate region; other site 698970001509 ABC-ATPase subunit interface; other site 698970001510 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 698970001511 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 698970001512 Walker A/P-loop; other site 698970001513 ATP binding site [chemical binding]; other site 698970001514 Q-loop/lid; other site 698970001515 ABC transporter signature motif; other site 698970001516 Walker B; other site 698970001517 D-loop; other site 698970001518 H-loop/switch region; other site 698970001519 NIL domain; Region: NIL; cl09633 698970001520 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698970001521 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 698970001522 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698970001523 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 698970001524 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 698970001525 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 698970001526 active site 698970001527 PHP Thumb interface [polypeptide binding]; other site 698970001528 Uncharacterized conserved protein [Function unknown]; Region: COG3402 698970001529 Predicted membrane protein [Function unknown]; Region: COG3428 698970001530 Bacterial PH domain; Region: DUF304; pfam03703 698970001531 Bacterial PH domain; Region: DUF304; pfam03703 698970001532 Bacterial PH domain; Region: DUF304; pfam03703 698970001533 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698970001534 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698970001535 intersubunit interface [polypeptide binding]; other site 698970001536 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698970001537 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698970001538 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698970001539 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698970001540 dimer interface [polypeptide binding]; other site 698970001541 putative PBP binding regions; other site 698970001542 ABC-ATPase subunit interface; other site 698970001543 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698970001544 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698970001545 ABC-ATPase subunit interface; other site 698970001546 dimer interface [polypeptide binding]; other site 698970001547 putative PBP binding regions; other site 698970001548 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698970001549 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698970001550 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698970001551 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 698970001552 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 698970001553 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 698970001554 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 698970001555 homodimer interface [polypeptide binding]; other site 698970001556 NADP binding site [chemical binding]; other site 698970001557 substrate binding site [chemical binding]; other site 698970001558 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 698970001559 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698970001560 active site 698970001561 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 698970001562 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 698970001563 Htaa; Region: HtaA; pfam04213 698970001564 Htaa; Region: HtaA; pfam04213 698970001565 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698970001566 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698970001567 intersubunit interface [polypeptide binding]; other site 698970001568 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698970001569 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698970001570 ABC-ATPase subunit interface; other site 698970001571 dimer interface [polypeptide binding]; other site 698970001572 putative PBP binding regions; other site 698970001573 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 698970001574 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698970001575 Walker A/P-loop; other site 698970001576 ATP binding site [chemical binding]; other site 698970001577 Q-loop/lid; other site 698970001578 ABC transporter signature motif; other site 698970001579 Walker B; other site 698970001580 D-loop; other site 698970001581 H-loop/switch region; other site 698970001582 Htaa; Region: HtaA; pfam04213 698970001583 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 698970001584 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698970001585 homodimer interface [polypeptide binding]; other site 698970001586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698970001587 substrate-cofactor binding pocket; other site 698970001588 catalytic residue [active] 698970001589 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 698970001590 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 698970001591 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698970001592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970001593 putative substrate translocation pore; other site 698970001594 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698970001595 putative catalytic site [active] 698970001596 putative metal binding site [ion binding]; other site 698970001597 putative phosphate binding site [ion binding]; other site 698970001598 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 698970001599 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 698970001600 active site 698970001601 HIGH motif; other site 698970001602 dimer interface [polypeptide binding]; other site 698970001603 KMSKS motif; other site 698970001604 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 698970001605 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698970001606 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698970001607 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698970001608 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698970001609 NlpC/P60 family; Region: NLPC_P60; pfam00877 698970001610 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698970001611 active site 698970001612 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698970001613 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698970001614 non-specific DNA binding site [nucleotide binding]; other site 698970001615 salt bridge; other site 698970001616 sequence-specific DNA binding site [nucleotide binding]; other site 698970001617 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698970001618 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 698970001619 metal binding site [ion binding]; metal-binding site 698970001620 putative dimer interface [polypeptide binding]; other site 698970001621 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 698970001622 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698970001623 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698970001624 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698970001625 pyruvate carboxylase; Reviewed; Region: PRK12999 698970001626 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698970001627 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698970001628 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698970001629 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698970001630 active site 698970001631 catalytic residues [active] 698970001632 metal binding site [ion binding]; metal-binding site 698970001633 homodimer binding site [polypeptide binding]; other site 698970001634 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698970001635 carboxyltransferase (CT) interaction site; other site 698970001636 biotinylation site [posttranslational modification]; other site 698970001637 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 698970001638 ADP-ribose binding site [chemical binding]; other site 698970001639 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 698970001640 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698970001641 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 698970001642 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 698970001643 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698970001644 carboxyltransferase (CT) interaction site; other site 698970001645 biotinylation site [posttranslational modification]; other site 698970001646 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698970001647 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698970001648 active site residue [active] 698970001649 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698970001650 active site residue [active] 698970001651 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698970001652 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 698970001653 active site 698970001654 dimer interface [polypeptide binding]; other site 698970001655 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 698970001656 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698970001657 substrate binding site [chemical binding]; other site 698970001658 dimer interface [polypeptide binding]; other site 698970001659 ATP binding site [chemical binding]; other site 698970001660 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698970001661 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698970001662 DNA binding site [nucleotide binding] 698970001663 domain linker motif; other site 698970001664 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 698970001665 dimerization interface [polypeptide binding]; other site 698970001666 putative ligand binding site [chemical binding]; other site 698970001667 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 698970001668 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698970001669 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698970001670 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698970001671 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698970001672 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698970001673 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698970001674 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 698970001675 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 698970001676 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 698970001677 ATP-grasp domain; Region: ATP-grasp; pfam02222 698970001678 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 698970001679 Uncharacterized conserved protein [Function unknown]; Region: COG1434 698970001680 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698970001681 putative active site [active] 698970001682 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 698970001683 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 698970001684 HupF/HypC family; Region: HupF_HypC; pfam01455 698970001685 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 698970001686 dimerization interface [polypeptide binding]; other site 698970001687 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 698970001688 ATP binding site [chemical binding]; other site 698970001689 Acylphosphatase; Region: Acylphosphatase; pfam00708 698970001690 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 698970001691 HypF finger; Region: zf-HYPF; pfam07503 698970001692 HypF finger; Region: zf-HYPF; pfam07503 698970001693 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 698970001694 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 698970001695 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698970001696 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 698970001697 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 698970001698 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 698970001699 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 698970001700 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 698970001701 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 698970001702 putative substrate-binding site; other site 698970001703 nickel binding site [ion binding]; other site 698970001704 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 698970001705 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 698970001706 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 698970001707 HupF/HypC family; Region: HupF_HypC; pfam01455 698970001708 TIGR03089 family protein; Region: TIGR03089 698970001709 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698970001710 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698970001711 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698970001712 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698970001713 active site 698970001714 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698970001715 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 698970001716 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 698970001717 active site 698970001718 Substrate binding site; other site 698970001719 Mg++ binding site; other site 698970001720 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698970001721 putative trimer interface [polypeptide binding]; other site 698970001722 putative CoA binding site [chemical binding]; other site 698970001723 Transcription factor WhiB; Region: Whib; pfam02467 698970001724 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 698970001725 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 698970001726 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 698970001727 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 698970001728 active site 698970001729 substrate binding site [chemical binding]; other site 698970001730 metal binding site [ion binding]; metal-binding site 698970001731 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 698970001732 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698970001733 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698970001734 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 698970001735 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 698970001736 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 698970001737 homotetramer interface [polypeptide binding]; other site 698970001738 ligand binding site [chemical binding]; other site 698970001739 catalytic site [active] 698970001740 NAD binding site [chemical binding]; other site 698970001741 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 698970001742 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 698970001743 TMP-binding site; other site 698970001744 ATP-binding site [chemical binding]; other site 698970001745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698970001746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698970001747 active site 698970001748 phosphorylation site [posttranslational modification] 698970001749 intermolecular recognition site; other site 698970001750 dimerization interface [polypeptide binding]; other site 698970001751 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698970001752 DNA binding site [nucleotide binding] 698970001753 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698970001754 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698970001755 dimerization interface [polypeptide binding]; other site 698970001756 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698970001757 dimer interface [polypeptide binding]; other site 698970001758 phosphorylation site [posttranslational modification] 698970001759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698970001760 ATP binding site [chemical binding]; other site 698970001761 Mg2+ binding site [ion binding]; other site 698970001762 G-X-G motif; other site 698970001763 lipoprotein LpqB; Provisional; Region: PRK13616 698970001764 Sporulation and spore germination; Region: Germane; pfam10646 698970001765 comF family protein; Region: comF; TIGR00201 698970001766 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698970001767 active site 698970001768 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 698970001769 30S subunit binding site; other site 698970001770 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 698970001771 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698970001772 ATP binding site [chemical binding]; other site 698970001773 putative Mg++ binding site [ion binding]; other site 698970001774 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 698970001775 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698970001776 nucleotide binding region [chemical binding]; other site 698970001777 ATP-binding site [chemical binding]; other site 698970001778 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 698970001779 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 698970001780 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698970001781 FAD binding pocket [chemical binding]; other site 698970001782 FAD binding motif [chemical binding]; other site 698970001783 phosphate binding motif [ion binding]; other site 698970001784 beta-alpha-beta structure motif; other site 698970001785 NAD binding pocket [chemical binding]; other site 698970001786 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698970001787 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 698970001788 catalytic loop [active] 698970001789 iron binding site [ion binding]; other site 698970001790 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 698970001791 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 698970001792 putative di-iron ligands [ion binding]; other site 698970001793 Predicted GTPases [General function prediction only]; Region: COG1162 698970001794 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 698970001795 GTPase/Zn-binding domain interface [polypeptide binding]; other site 698970001796 GTP/Mg2+ binding site [chemical binding]; other site 698970001797 G4 box; other site 698970001798 G5 box; other site 698970001799 G1 box; other site 698970001800 Switch I region; other site 698970001801 G2 box; other site 698970001802 G3 box; other site 698970001803 Switch II region; other site 698970001804 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 698970001805 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 698970001806 hinge; other site 698970001807 active site 698970001808 Uncharacterized conserved protein [Function unknown]; Region: COG2135 698970001809 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 698970001810 putative deacylase active site [active] 698970001811 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 698970001812 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698970001813 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698970001814 DNA binding residues [nucleotide binding] 698970001815 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 698970001816 Transcription factor WhiB; Region: Whib; pfam02467 698970001817 PQQ-like domain; Region: PQQ_2; pfam13360 698970001818 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698970001819 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698970001820 ATP binding site [chemical binding]; other site 698970001821 putative Mg++ binding site [ion binding]; other site 698970001822 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698970001823 nucleotide binding region [chemical binding]; other site 698970001824 ATP-binding site [chemical binding]; other site 698970001825 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 698970001826 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 698970001827 TIGR02569 family protein; Region: TIGR02569_actnb 698970001828 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698970001829 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698970001830 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698970001831 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698970001832 Part of AAA domain; Region: AAA_19; pfam13245 698970001833 Family description; Region: UvrD_C_2; pfam13538 698970001834 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698970001835 Ion channel; Region: Ion_trans_2; pfam07885 698970001836 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 698970001837 TrkA-N domain; Region: TrkA_N; pfam02254 698970001838 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 698970001839 putative NADH binding site [chemical binding]; other site 698970001840 putative active site [active] 698970001841 nudix motif; other site 698970001842 putative metal binding site [ion binding]; other site 698970001843 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 698970001844 Part of AAA domain; Region: AAA_19; pfam13245 698970001845 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698970001846 Family description; Region: UvrD_C_2; pfam13538 698970001847 HRDC domain; Region: HRDC; pfam00570 698970001848 Protein of unknown function DUF45; Region: DUF45; pfam01863 698970001849 putative hydrolase; Region: TIGR03624 698970001850 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 698970001851 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698970001852 hypothetical protein; Validated; Region: PRK00068 698970001853 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 698970001854 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698970001855 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698970001856 HTH-like domain; Region: HTH_21; pfam13276 698970001857 Integrase core domain; Region: rve; pfam00665 698970001858 Integrase core domain; Region: rve_2; pfam13333 698970001859 potential frameshift: common BLAST hit: gi|172041642|ref|YP_001801356.1| transposase for insertion sequence 698970001860 Helix-turn-helix domain; Region: HTH_38; pfam13936 698970001861 Integrase core domain; Region: rve; pfam00665 698970001862 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698970001863 Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731 698970001864 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 698970001865 FIC domain binding interface [polypeptide binding]; other site 698970001866 Fic/DOC family; Region: Fic; cl00960 698970001867 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698970001868 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698970001869 P-loop; other site 698970001870 Magnesium ion binding site [ion binding]; other site 698970001871 Winged helix-turn helix; Region: HTH_29; pfam13551 698970001872 Helix-turn-helix domain; Region: HTH_28; pfam13518 698970001873 putative transposase OrfB; Reviewed; Region: PHA02517 698970001874 HTH-like domain; Region: HTH_21; pfam13276 698970001875 Integrase core domain; Region: rve; pfam00665 698970001876 Integrase core domain; Region: rve_2; pfam13333 698970001877 potential frameshift: common BLAST hit: gi|172041279|ref|YP_001800993.1| transposase for insertion sequence 698970001878 HTH-like domain; Region: HTH_21; pfam13276 698970001879 Integrase core domain; Region: rve; pfam00665 698970001880 Integrase core domain; Region: rve_2; pfam13333 698970001881 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698970001882 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 698970001883 active site 698970001884 oxaloacetate decarboxylase; Provisional; Region: PRK12330 698970001885 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698970001886 active site 698970001887 catalytic residues [active] 698970001888 metal binding site [ion binding]; metal-binding site 698970001889 homodimer binding site [polypeptide binding]; other site 698970001890 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 698970001891 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698970001892 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698970001893 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698970001894 carboxyltransferase (CT) interaction site; other site 698970001895 biotinylation site [posttranslational modification]; other site 698970001896 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698970001897 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 698970001898 active site 698970001899 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698970001900 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698970001901 active site 698970001902 peptide chain release factor 2; Validated; Region: prfB; PRK00578 698970001903 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698970001904 RF-1 domain; Region: RF-1; pfam00472 698970001905 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 698970001906 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698970001907 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970001908 Walker A/P-loop; other site 698970001909 ATP binding site [chemical binding]; other site 698970001910 Q-loop/lid; other site 698970001911 ABC transporter signature motif; other site 698970001912 Walker B; other site 698970001913 D-loop; other site 698970001914 H-loop/switch region; other site 698970001915 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 698970001916 FtsX-like permease family; Region: FtsX; pfam02687 698970001917 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 698970001918 SmpB-tmRNA interface; other site 698970001919 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698970001920 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698970001921 HTH-like domain; Region: HTH_21; pfam13276 698970001922 Integrase core domain; Region: rve; pfam00665 698970001923 Integrase core domain; Region: rve_2; pfam13333 698970001924 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 698970001925 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 698970001926 active site 698970001927 zinc binding site [ion binding]; other site 698970001928 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39F; cd02425 698970001929 putative active site [active] 698970001930 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698970001931 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698970001932 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 698970001933 Walker A/P-loop; other site 698970001934 ATP binding site [chemical binding]; other site 698970001935 Q-loop/lid; other site 698970001936 ABC transporter signature motif; other site 698970001937 Walker B; other site 698970001938 D-loop; other site 698970001939 H-loop/switch region; other site 698970001940 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698970001941 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698970001942 Walker A/P-loop; other site 698970001943 ATP binding site [chemical binding]; other site 698970001944 Q-loop/lid; other site 698970001945 ABC transporter signature motif; other site 698970001946 Walker B; other site 698970001947 D-loop; other site 698970001948 H-loop/switch region; other site 698970001949 Integrase core domain; Region: rve_3; pfam13683 698970001950 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698970001951 HTH-like domain; Region: HTH_21; pfam13276 698970001952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698970001953 Integrase core domain; Region: rve; pfam00665 698970001954 Integrase core domain; Region: rve_3; pfam13683 698970001955 Cupin domain; Region: Cupin_2; cl17218 698970001956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698970001957 S-adenosylmethionine binding site [chemical binding]; other site 698970001958 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698970001959 Integrase core domain; Region: rve_3; pfam13683 698970001960 potential frameshift: common BLAST hit: gi|38233368|ref|NP_939135.1| transposase 698970001961 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698970001962 Integrase core domain; Region: rve; pfam00665 698970001963 Helix-turn-helix domain; Region: HTH_38; pfam13936 698970001964 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698970001965 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698970001966 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698970001967 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698970001968 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698970001969 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 698970001970 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698970001971 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698970001972 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698970001973 nucleotide binding region [chemical binding]; other site 698970001974 ATP-binding site [chemical binding]; other site 698970001975 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698970001976 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698970001977 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 698970001978 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698970001979 DNA-binding site [nucleotide binding]; DNA binding site 698970001980 RNA-binding motif; other site 698970001981 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 698970001982 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 698970001983 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 698970001984 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 698970001985 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698970001986 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698970001987 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 698970001988 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698970001989 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698970001990 catalytic residue [active] 698970001991 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 698970001992 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 698970001993 dimer interface [polypeptide binding]; other site 698970001994 active site 698970001995 citrylCoA binding site [chemical binding]; other site 698970001996 NADH binding [chemical binding]; other site 698970001997 cationic pore residues; other site 698970001998 oxalacetate/citrate binding site [chemical binding]; other site 698970001999 coenzyme A binding site [chemical binding]; other site 698970002000 catalytic triad [active] 698970002001 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698970002002 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 698970002003 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698970002004 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698970002005 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698970002006 active site 698970002007 catalytic tetrad [active] 698970002008 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 698970002009 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698970002010 substrate binding site [chemical binding]; other site 698970002011 oxyanion hole (OAH) forming residues; other site 698970002012 trimer interface [polypeptide binding]; other site 698970002013 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698970002014 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698970002015 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698970002016 Protein of unknown function, DUF485; Region: DUF485; pfam04341 698970002017 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698970002018 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 698970002019 Na binding site [ion binding]; other site 698970002020 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 698970002021 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 698970002022 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698970002023 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 698970002024 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698970002025 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698970002026 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698970002027 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698970002028 active site 698970002029 catalytic residues [active] 698970002030 DNA binding site [nucleotide binding] 698970002031 Int/Topo IB signature motif; other site 698970002032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698970002033 sequence-specific DNA binding site [nucleotide binding]; other site 698970002034 salt bridge; other site 698970002035 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698970002036 active site 698970002037 catalytic residues [active] 698970002038 DNA binding site [nucleotide binding] 698970002039 Int/Topo IB signature motif; other site 698970002040 Homeodomain-like domain; Region: HTH_23; cl17451 698970002041 Helix-turn-helix domain; Region: HTH_28; pfam13518 698970002042 putative transposase OrfB; Reviewed; Region: PHA02517 698970002043 HTH-like domain; Region: HTH_21; pfam13276 698970002044 Integrase core domain; Region: rve; pfam00665 698970002045 Integrase core domain; Region: rve_2; pfam13333 698970002046 XamI restriction endonuclease; Region: RE_XamI; pfam09572 698970002047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698970002048 S-adenosylmethionine binding site [chemical binding]; other site 698970002049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 698970002050 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698970002051 MULE transposase domain; Region: MULE; pfam10551 698970002052 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 698970002053 active site 698970002054 SAM binding site [chemical binding]; other site 698970002055 homodimer interface [polypeptide binding]; other site 698970002056 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698970002057 catalytic residues [active] 698970002058 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 698970002059 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 698970002060 folate binding site [chemical binding]; other site 698970002061 NADP+ binding site [chemical binding]; other site 698970002062 thymidylate synthase; Reviewed; Region: thyA; PRK01827 698970002063 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 698970002064 dimerization interface [polypeptide binding]; other site 698970002065 active site 698970002066 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 698970002067 active site 698970002068 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698970002069 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 698970002070 ATP binding site [chemical binding]; other site 698970002071 putative Mg++ binding site [ion binding]; other site 698970002072 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698970002073 nucleotide binding region [chemical binding]; other site 698970002074 ATP-binding site [chemical binding]; other site 698970002075 DEAD/H associated; Region: DEAD_assoc; pfam08494 698970002076 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 698970002077 active site 698970002078 SUMO-1 interface [polypeptide binding]; other site 698970002079 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698970002080 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 698970002081 putative DNA binding site [nucleotide binding]; other site 698970002082 catalytic residue [active] 698970002083 putative H2TH interface [polypeptide binding]; other site 698970002084 putative catalytic residues [active] 698970002085 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698970002086 Predicted permease [General function prediction only]; Region: COG2985 698970002087 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698970002088 TrkA-C domain; Region: TrkA_C; pfam02080 698970002089 TrkA-C domain; Region: TrkA_C; pfam02080 698970002090 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698970002091 hypothetical protein; Provisional; Region: PRK11770 698970002092 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698970002093 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698970002094 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 698970002095 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 698970002096 active site 698970002097 dimer interface [polypeptide binding]; other site 698970002098 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 698970002099 dimer interface [polypeptide binding]; other site 698970002100 active site 698970002101 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698970002102 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698970002103 tetramerization interface [polypeptide binding]; other site 698970002104 NAD(P) binding site [chemical binding]; other site 698970002105 catalytic residues [active] 698970002106 hypothetical protein; Provisional; Region: PRK07857 698970002107 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 698970002108 Part of AAA domain; Region: AAA_19; pfam13245 698970002109 Family description; Region: UvrD_C_2; pfam13538 698970002110 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698970002111 Peptidase family M23; Region: Peptidase_M23; pfam01551 698970002112 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 698970002113 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 698970002114 active site 698970002115 substrate binding site [chemical binding]; other site 698970002116 cosubstrate binding site; other site 698970002117 catalytic site [active] 698970002118 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 698970002119 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 698970002120 purine monophosphate binding site [chemical binding]; other site 698970002121 dimer interface [polypeptide binding]; other site 698970002122 putative catalytic residues [active] 698970002123 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 698970002124 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698970002125 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 698970002126 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698970002127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698970002128 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 698970002129 30S ribosomal protein S18; Provisional; Region: PRK13401 698970002130 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 698970002131 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 698970002132 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 698970002133 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 698970002134 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 698970002135 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698970002136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698970002137 active site 698970002138 phosphorylation site [posttranslational modification] 698970002139 intermolecular recognition site; other site 698970002140 dimerization interface [polypeptide binding]; other site 698970002141 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698970002142 DNA binding site [nucleotide binding] 698970002143 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698970002144 dimerization interface [polypeptide binding]; other site 698970002145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698970002146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698970002147 dimer interface [polypeptide binding]; other site 698970002148 phosphorylation site [posttranslational modification] 698970002149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698970002150 ATP binding site [chemical binding]; other site 698970002151 Mg2+ binding site [ion binding]; other site 698970002152 G-X-G motif; other site 698970002153 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698970002154 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698970002155 protein binding site [polypeptide binding]; other site 698970002156 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698970002157 MPT binding site; other site 698970002158 trimer interface [polypeptide binding]; other site 698970002159 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 698970002160 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 698970002161 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 698970002162 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 698970002163 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 698970002164 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 698970002165 active site 698970002166 tetramer interface; other site 698970002167 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698970002168 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698970002169 dimer interface [polypeptide binding]; other site 698970002170 putative functional site; other site 698970002171 putative MPT binding site; other site 698970002172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698970002173 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698970002174 Predicted membrane protein [Function unknown]; Region: COG2259 698970002175 Predicted integral membrane protein [Function unknown]; Region: COG5660 698970002176 Putative zinc-finger; Region: zf-HC2; pfam13490 698970002177 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 698970002178 BCCT family transporter; Region: BCCT; pfam02028 698970002179 Uncharacterized membrane protein [Function unknown]; Region: COG3949 698970002180 Predicted methyltransferases [General function prediction only]; Region: COG0313 698970002181 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 698970002182 putative SAM binding site [chemical binding]; other site 698970002183 putative homodimer interface [polypeptide binding]; other site 698970002184 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 698970002185 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 698970002186 active site 698970002187 HIGH motif; other site 698970002188 KMSKS motif; other site 698970002189 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 698970002190 tRNA binding surface [nucleotide binding]; other site 698970002191 anticodon binding site; other site 698970002192 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 698970002193 active site 698970002194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 698970002195 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698970002196 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698970002197 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698970002198 G5 domain; Region: G5; pfam07501 698970002199 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698970002200 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 698970002201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698970002202 S-adenosylmethionine binding site [chemical binding]; other site 698970002203 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 698970002204 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698970002205 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698970002206 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698970002207 ABC transporter; Region: ABC_tran_2; pfam12848 698970002208 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698970002209 Uncharacterized conserved protein [Function unknown]; Region: COG1359 698970002210 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698970002211 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698970002212 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698970002213 DNA binding residues [nucleotide binding] 698970002214 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698970002215 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 698970002216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698970002217 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698970002218 active site 698970002219 motif I; other site 698970002220 motif II; other site 698970002221 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698970002222 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 698970002223 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698970002224 substrate binding site [chemical binding]; other site 698970002225 oxyanion hole (OAH) forming residues; other site 698970002226 trimer interface [polypeptide binding]; other site 698970002227 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 698970002228 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698970002229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698970002230 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 698970002231 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 698970002232 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698970002233 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 698970002234 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 698970002235 G1 box; other site 698970002236 putative GEF interaction site [polypeptide binding]; other site 698970002237 GTP/Mg2+ binding site [chemical binding]; other site 698970002238 Switch I region; other site 698970002239 G2 box; other site 698970002240 G3 box; other site 698970002241 Switch II region; other site 698970002242 G4 box; other site 698970002243 G5 box; other site 698970002244 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 698970002245 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698970002246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698970002247 NAD(P) binding site [chemical binding]; other site 698970002248 active site 698970002249 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698970002250 putative active site [active] 698970002251 catalytic residue [active] 698970002252 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698970002253 active site 698970002254 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698970002255 putative active site [active] 698970002256 catalytic residue [active] 698970002257 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 698970002258 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 698970002259 5S rRNA interface [nucleotide binding]; other site 698970002260 CTC domain interface [polypeptide binding]; other site 698970002261 L16 interface [polypeptide binding]; other site 698970002262 pullulanase, type I; Region: pulA_typeI; TIGR02104 698970002263 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 698970002264 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 698970002265 Ca binding site [ion binding]; other site 698970002266 active site 698970002267 catalytic site [active] 698970002268 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 698970002269 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 698970002270 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698970002271 active site 698970002272 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 698970002273 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 698970002274 Substrate binding site; other site 698970002275 Mg++ binding site; other site 698970002276 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 698970002277 active site 698970002278 substrate binding site [chemical binding]; other site 698970002279 CoA binding site [chemical binding]; other site 698970002280 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698970002281 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698970002282 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 698970002283 putative dimerization interface [polypeptide binding]; other site 698970002284 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 698970002285 gating phenylalanine in ion channel; other site 698970002286 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698970002287 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 698970002288 putative ligand binding site [chemical binding]; other site 698970002289 putative NAD binding site [chemical binding]; other site 698970002290 catalytic site [active] 698970002291 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698970002292 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698970002293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970002294 Q-loop/lid; other site 698970002295 ABC transporter signature motif; other site 698970002296 Walker B; other site 698970002297 D-loop; other site 698970002298 H-loop/switch region; other site 698970002299 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698970002300 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698970002301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970002302 Walker A/P-loop; other site 698970002303 ATP binding site [chemical binding]; other site 698970002304 Q-loop/lid; other site 698970002305 ABC transporter signature motif; other site 698970002306 Walker B; other site 698970002307 D-loop; other site 698970002308 H-loop/switch region; other site 698970002309 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698970002310 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698970002311 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 698970002312 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 698970002313 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698970002314 ATP binding site [chemical binding]; other site 698970002315 putative Mg++ binding site [ion binding]; other site 698970002316 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698970002317 nucleotide binding region [chemical binding]; other site 698970002318 ATP-binding site [chemical binding]; other site 698970002319 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 698970002320 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 698970002321 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 698970002322 homodimer interface [polypeptide binding]; other site 698970002323 metal binding site [ion binding]; metal-binding site 698970002324 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698970002325 enolase; Provisional; Region: eno; PRK00077 698970002326 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 698970002327 dimer interface [polypeptide binding]; other site 698970002328 metal binding site [ion binding]; metal-binding site 698970002329 substrate binding pocket [chemical binding]; other site 698970002330 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 698970002331 Septum formation initiator; Region: DivIC; pfam04977 698970002332 Uncharacterized conserved protein [Function unknown]; Region: COG1507 698970002333 exopolyphosphatase; Region: exo_poly_only; TIGR03706 698970002334 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698970002335 Helix-turn-helix domain; Region: HTH_18; pfam12833 698970002336 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698970002337 Bax inhibitor 1 like; Region: BaxI_1; cl17691 698970002338 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 698970002339 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 698970002340 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 698970002341 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 698970002342 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 698970002343 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 698970002344 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698970002345 catalytic residue [active] 698970002346 putative FPP diphosphate binding site; other site 698970002347 putative FPP binding hydrophobic cleft; other site 698970002348 dimer interface [polypeptide binding]; other site 698970002349 putative IPP diphosphate binding site; other site 698970002350 Flavodoxin domain; Region: Flavodoxin_5; cl17428 698970002351 pantothenate kinase; Provisional; Region: PRK05439 698970002352 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 698970002353 ATP-binding site [chemical binding]; other site 698970002354 CoA-binding site [chemical binding]; other site 698970002355 Mg2+-binding site [ion binding]; other site 698970002356 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 698970002357 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 698970002358 dimer interface [polypeptide binding]; other site 698970002359 active site 698970002360 glycine-pyridoxal phosphate binding site [chemical binding]; other site 698970002361 folate binding site [chemical binding]; other site 698970002362 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698970002363 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 698970002364 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698970002365 Coenzyme A binding pocket [chemical binding]; other site 698970002366 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698970002367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970002368 putative substrate translocation pore; other site 698970002369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970002370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698970002371 fumarate hydratase; Reviewed; Region: fumC; PRK00485 698970002372 Class II fumarases; Region: Fumarase_classII; cd01362 698970002373 active site 698970002374 tetramer interface [polypeptide binding]; other site 698970002375 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 698970002376 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 698970002377 putative active site [active] 698970002378 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 698970002379 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 698970002380 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 698970002381 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 698970002382 generic binding surface II; other site 698970002383 generic binding surface I; other site 698970002384 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 698970002385 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 698970002386 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 698970002387 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698970002388 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698970002389 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 698970002390 Na2 binding site [ion binding]; other site 698970002391 putative substrate binding site 1 [chemical binding]; other site 698970002392 Na binding site 1 [ion binding]; other site 698970002393 putative substrate binding site 2 [chemical binding]; other site 698970002394 GTP-binding protein YchF; Reviewed; Region: PRK09601 698970002395 YchF GTPase; Region: YchF; cd01900 698970002396 G1 box; other site 698970002397 GTP/Mg2+ binding site [chemical binding]; other site 698970002398 Switch I region; other site 698970002399 G2 box; other site 698970002400 Switch II region; other site 698970002401 G3 box; other site 698970002402 G4 box; other site 698970002403 G5 box; other site 698970002404 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 698970002405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 698970002406 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 698970002407 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 698970002408 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 698970002409 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 698970002410 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 698970002411 Cl- selectivity filter; other site 698970002412 Cl- binding residues [ion binding]; other site 698970002413 pore gating glutamate residue; other site 698970002414 dimer interface [polypeptide binding]; other site 698970002415 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698970002416 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698970002417 Walker A/P-loop; other site 698970002418 ATP binding site [chemical binding]; other site 698970002419 Q-loop/lid; other site 698970002420 ABC transporter signature motif; other site 698970002421 Walker B; other site 698970002422 D-loop; other site 698970002423 H-loop/switch region; other site 698970002424 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 698970002425 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698970002426 Walker A/P-loop; other site 698970002427 ATP binding site [chemical binding]; other site 698970002428 Q-loop/lid; other site 698970002429 ABC transporter signature motif; other site 698970002430 Walker B; other site 698970002431 D-loop; other site 698970002432 H-loop/switch region; other site 698970002433 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698970002434 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 698970002435 active site 698970002436 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698970002437 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698970002438 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698970002439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698970002440 dimer interface [polypeptide binding]; other site 698970002441 conserved gate region; other site 698970002442 ABC-ATPase subunit interface; other site 698970002443 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698970002444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698970002445 dimer interface [polypeptide binding]; other site 698970002446 conserved gate region; other site 698970002447 putative PBP binding loops; other site 698970002448 ABC-ATPase subunit interface; other site 698970002449 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698970002450 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698970002451 Walker A/P-loop; other site 698970002452 ATP binding site [chemical binding]; other site 698970002453 Q-loop/lid; other site 698970002454 ABC transporter signature motif; other site 698970002455 Walker B; other site 698970002456 D-loop; other site 698970002457 H-loop/switch region; other site 698970002458 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698970002459 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698970002460 Walker A/P-loop; other site 698970002461 ATP binding site [chemical binding]; other site 698970002462 Q-loop/lid; other site 698970002463 ABC transporter signature motif; other site 698970002464 Walker B; other site 698970002465 D-loop; other site 698970002466 H-loop/switch region; other site 698970002467 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698970002468 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698970002469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970002470 Walker A/P-loop; other site 698970002471 ATP binding site [chemical binding]; other site 698970002472 ABC transporter signature motif; other site 698970002473 Walker B; other site 698970002474 D-loop; other site 698970002475 H-loop/switch region; other site 698970002476 Trypsin; Region: Trypsin; pfam00089 698970002477 active site 698970002478 substrate binding sites [chemical binding]; other site 698970002479 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 698970002480 ArsC family; Region: ArsC; pfam03960 698970002481 catalytic residues [active] 698970002482 Protein of unknown function (DUF402); Region: DUF402; cl00979 698970002483 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 698970002484 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 698970002485 G1 box; other site 698970002486 GTP/Mg2+ binding site [chemical binding]; other site 698970002487 G2 box; other site 698970002488 Switch I region; other site 698970002489 G3 box; other site 698970002490 Switch II region; other site 698970002491 G4 box; other site 698970002492 G5 box; other site 698970002493 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 698970002494 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 698970002495 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 698970002496 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698970002497 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 698970002498 Ferredoxin [Energy production and conversion]; Region: COG1146 698970002499 4Fe-4S binding domain; Region: Fer4; pfam00037 698970002500 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 698970002501 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698970002502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698970002503 homodimer interface [polypeptide binding]; other site 698970002504 catalytic residue [active] 698970002505 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698970002506 active site 698970002507 Predicted membrane protein [Function unknown]; Region: COG2246 698970002508 GtrA-like protein; Region: GtrA; pfam04138 698970002509 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698970002510 active site 698970002511 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 698970002512 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698970002513 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 698970002514 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 698970002515 putative trimer interface [polypeptide binding]; other site 698970002516 putative CoA binding site [chemical binding]; other site 698970002517 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 698970002518 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698970002519 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 698970002520 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698970002521 putative trimer interface [polypeptide binding]; other site 698970002522 putative CoA binding site [chemical binding]; other site 698970002523 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 698970002524 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 698970002525 metal binding site [ion binding]; metal-binding site 698970002526 putative dimer interface [polypeptide binding]; other site 698970002527 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698970002528 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698970002529 dihydropteroate synthase; Region: DHPS; TIGR01496 698970002530 substrate binding pocket [chemical binding]; other site 698970002531 dimer interface [polypeptide binding]; other site 698970002532 inhibitor binding site; inhibition site 698970002533 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 698970002534 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 698970002535 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 698970002536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698970002537 S-adenosylmethionine binding site [chemical binding]; other site 698970002538 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 698970002539 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 698970002540 active site 698970002541 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 698970002542 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 698970002543 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 698970002544 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698970002545 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 698970002546 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 698970002547 ligand binding site; other site 698970002548 oligomer interface; other site 698970002549 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 698970002550 dimer interface [polypeptide binding]; other site 698970002551 N-terminal domain interface [polypeptide binding]; other site 698970002552 sulfate 1 binding site; other site 698970002553 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 698970002554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698970002555 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 698970002556 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698970002557 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698970002558 DNA binding residues [nucleotide binding] 698970002559 Putative zinc-finger; Region: zf-HC2; pfam13490 698970002560 sec-independent translocase; Provisional; Region: tatB; PRK00182 698970002561 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 698970002562 Domain of unknown function DUF59; Region: DUF59; pfam01883 698970002563 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 698970002564 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 698970002565 Predicted membrane protein [Function unknown]; Region: COG4420 698970002566 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 698970002567 MgtE intracellular N domain; Region: MgtE_N; smart00924 698970002568 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 698970002569 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 698970002570 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 698970002571 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698970002572 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 698970002573 TPP-binding site [chemical binding]; other site 698970002574 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 698970002575 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698970002576 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698970002577 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970002578 Walker A/P-loop; other site 698970002579 ATP binding site [chemical binding]; other site 698970002580 Q-loop/lid; other site 698970002581 ABC transporter signature motif; other site 698970002582 Walker B; other site 698970002583 D-loop; other site 698970002584 H-loop/switch region; other site 698970002585 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698970002586 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698970002587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970002588 Walker A/P-loop; other site 698970002589 ATP binding site [chemical binding]; other site 698970002590 Q-loop/lid; other site 698970002591 ABC transporter signature motif; other site 698970002592 Walker B; other site 698970002593 D-loop; other site 698970002594 H-loop/switch region; other site 698970002595 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 698970002596 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698970002597 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698970002598 shikimate binding site; other site 698970002599 NAD(P) binding site [chemical binding]; other site 698970002600 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698970002601 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698970002602 substrate binding pocket [chemical binding]; other site 698970002603 catalytic triad [active] 698970002604 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 698970002605 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 698970002606 active site 698970002607 catalytic residues [active] 698970002608 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698970002609 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 698970002610 Na binding site [ion binding]; other site 698970002611 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698970002612 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 698970002613 nucleotide binding site/active site [active] 698970002614 HIT family signature motif; other site 698970002615 catalytic residue [active] 698970002616 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 698970002617 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698970002618 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698970002619 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698970002620 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 698970002621 PLD-like domain; Region: PLDc_2; pfam13091 698970002622 putative homodimer interface [polypeptide binding]; other site 698970002623 putative active site [active] 698970002624 catalytic site [active] 698970002625 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698970002626 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698970002627 putative Mg++ binding site [ion binding]; other site 698970002628 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698970002629 nucleotide binding region [chemical binding]; other site 698970002630 ATP-binding site [chemical binding]; other site 698970002631 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 698970002632 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 698970002633 active site 698970002634 8-oxo-dGMP binding site [chemical binding]; other site 698970002635 nudix motif; other site 698970002636 metal binding site [ion binding]; metal-binding site 698970002637 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 698970002638 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698970002639 ATP binding site [chemical binding]; other site 698970002640 Mg++ binding site [ion binding]; other site 698970002641 motif III; other site 698970002642 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698970002643 nucleotide binding region [chemical binding]; other site 698970002644 ATP-binding site [chemical binding]; other site 698970002645 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 698970002646 putative RNA binding site [nucleotide binding]; other site 698970002647 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698970002648 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698970002649 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 698970002650 Na binding site [ion binding]; other site 698970002651 SNF2 Helicase protein; Region: DUF3670; pfam12419 698970002652 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 698970002653 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698970002654 ATP binding site [chemical binding]; other site 698970002655 putative Mg++ binding site [ion binding]; other site 698970002656 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698970002657 nucleotide binding region [chemical binding]; other site 698970002658 ATP-binding site [chemical binding]; other site 698970002659 Uncharacterized conserved protein [Function unknown]; Region: COG4279 698970002660 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 698970002661 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 698970002662 active site 698970002663 metal binding site [ion binding]; metal-binding site 698970002664 DNA binding site [nucleotide binding] 698970002665 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 698970002666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970002667 Walker A/P-loop; other site 698970002668 ATP binding site [chemical binding]; other site 698970002669 Q-loop/lid; other site 698970002670 Uncharacterized conserved protein [Function unknown]; Region: COG2353 698970002671 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698970002672 MarR family; Region: MarR_2; pfam12802 698970002673 PspC domain; Region: PspC; cl00864 698970002674 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698970002675 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 698970002676 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698970002677 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 698970002678 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698970002679 Cysteine-rich domain; Region: CCG; pfam02754 698970002680 Cysteine-rich domain; Region: CCG; pfam02754 698970002681 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698970002682 L-lactate permease; Region: Lactate_perm; cl00701 698970002683 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 698970002684 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 698970002685 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 698970002686 active site 698970002687 HIGH motif; other site 698970002688 KMSK motif region; other site 698970002689 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 698970002690 tRNA binding surface [nucleotide binding]; other site 698970002691 anticodon binding site; other site 698970002692 diaminopimelate decarboxylase; Region: lysA; TIGR01048 698970002693 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 698970002694 active site 698970002695 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698970002696 substrate binding site [chemical binding]; other site 698970002697 catalytic residues [active] 698970002698 dimer interface [polypeptide binding]; other site 698970002699 homoserine dehydrogenase; Provisional; Region: PRK06349 698970002700 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 698970002701 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 698970002702 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 698970002703 homoserine kinase; Provisional; Region: PRK01212 698970002704 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 698970002705 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698970002706 acyl-activating enzyme (AAE) consensus motif; other site 698970002707 AMP binding site [chemical binding]; other site 698970002708 active site 698970002709 CoA binding site [chemical binding]; other site 698970002710 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 698970002711 transcription termination factor Rho; Provisional; Region: PRK12608 698970002712 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698970002713 RNA binding site [nucleotide binding]; other site 698970002714 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 698970002715 multimer interface [polypeptide binding]; other site 698970002716 Walker A motif; other site 698970002717 ATP binding site [chemical binding]; other site 698970002718 Walker B motif; other site 698970002719 peptide chain release factor 1; Validated; Region: prfA; PRK00591 698970002720 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698970002721 RF-1 domain; Region: RF-1; pfam00472 698970002722 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 698970002723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698970002724 S-adenosylmethionine binding site [chemical binding]; other site 698970002725 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 698970002726 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 698970002727 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 698970002728 Mg++ binding site [ion binding]; other site 698970002729 putative catalytic motif [active] 698970002730 substrate binding site [chemical binding]; other site 698970002731 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 698970002732 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 698970002733 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 698970002734 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 698970002735 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 698970002736 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 698970002737 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 698970002738 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 698970002739 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698970002740 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 698970002741 beta subunit interaction interface [polypeptide binding]; other site 698970002742 Walker A motif; other site 698970002743 ATP binding site [chemical binding]; other site 698970002744 Walker B motif; other site 698970002745 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698970002746 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 698970002747 core domain interface [polypeptide binding]; other site 698970002748 delta subunit interface [polypeptide binding]; other site 698970002749 epsilon subunit interface [polypeptide binding]; other site 698970002750 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 698970002751 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698970002752 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 698970002753 alpha subunit interaction interface [polypeptide binding]; other site 698970002754 Walker A motif; other site 698970002755 ATP binding site [chemical binding]; other site 698970002756 Walker B motif; other site 698970002757 inhibitor binding site; inhibition site 698970002758 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698970002759 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 698970002760 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 698970002761 gamma subunit interface [polypeptide binding]; other site 698970002762 epsilon subunit interface [polypeptide binding]; other site 698970002763 LBP interface [polypeptide binding]; other site 698970002764 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 698970002765 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 698970002766 hypothetical protein; Provisional; Region: PRK03298 698970002767 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 698970002768 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698970002769 dimer interface [polypeptide binding]; other site 698970002770 substrate binding site [chemical binding]; other site 698970002771 metal binding site [ion binding]; metal-binding site 698970002772 Domain of unknown function DUF77; Region: DUF77; pfam01910 698970002773 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698970002774 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698970002775 Walker A/P-loop; other site 698970002776 ATP binding site [chemical binding]; other site 698970002777 Q-loop/lid; other site 698970002778 ABC transporter signature motif; other site 698970002779 Walker B; other site 698970002780 D-loop; other site 698970002781 H-loop/switch region; other site 698970002782 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698970002783 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698970002784 ABC-ATPase subunit interface; other site 698970002785 dimer interface [polypeptide binding]; other site 698970002786 putative PBP binding regions; other site 698970002787 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698970002788 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698970002789 ABC-ATPase subunit interface; other site 698970002790 dimer interface [polypeptide binding]; other site 698970002791 putative PBP binding regions; other site 698970002792 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 698970002793 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698970002794 siderophore binding site; other site 698970002795 TIGR02611 family protein; Region: TIGR02611 698970002796 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 698970002797 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 698970002798 glycogen branching enzyme; Provisional; Region: PRK05402 698970002799 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 698970002800 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 698970002801 active site 698970002802 catalytic site [active] 698970002803 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 698970002804 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 698970002805 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 698970002806 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698970002807 active site 698970002808 homodimer interface [polypeptide binding]; other site 698970002809 catalytic site [active] 698970002810 acceptor binding site [chemical binding]; other site 698970002811 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698970002812 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970002813 Walker A/P-loop; other site 698970002814 ATP binding site [chemical binding]; other site 698970002815 Q-loop/lid; other site 698970002816 ABC transporter signature motif; other site 698970002817 Walker B; other site 698970002818 D-loop; other site 698970002819 H-loop/switch region; other site 698970002820 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 698970002821 Ligand binding site [chemical binding]; other site 698970002822 Electron transfer flavoprotein domain; Region: ETF; pfam01012 698970002823 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 698970002824 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 698970002825 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 698970002826 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 698970002827 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 698970002828 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698970002829 catalytic residue [active] 698970002830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698970002831 S-adenosylmethionine binding site [chemical binding]; other site 698970002832 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 698970002833 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 698970002834 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698970002835 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698970002836 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698970002837 active site 698970002838 catalytic site [active] 698970002839 substrate binding site [chemical binding]; other site 698970002840 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 698970002841 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 698970002842 nucleotide binding pocket [chemical binding]; other site 698970002843 K-X-D-G motif; other site 698970002844 catalytic site [active] 698970002845 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 698970002846 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 698970002847 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 698970002848 Dimer interface [polypeptide binding]; other site 698970002849 BRCT sequence motif; other site 698970002850 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698970002851 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 698970002852 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698970002853 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 698970002854 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 698970002855 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698970002856 Coenzyme A binding pocket [chemical binding]; other site 698970002857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970002858 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698970002859 putative substrate translocation pore; other site 698970002860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970002861 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698970002862 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698970002863 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698970002864 ABC-ATPase subunit interface; other site 698970002865 dimer interface [polypeptide binding]; other site 698970002866 putative PBP binding regions; other site 698970002867 proposed F420-0 ABC transporter, ATP-binding protein; Region: F420-0_ABC_ATP; TIGR03873 698970002868 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970002869 Walker A/P-loop; other site 698970002870 ATP binding site [chemical binding]; other site 698970002871 Q-loop/lid; other site 698970002872 ABC transporter signature motif; other site 698970002873 Walker B; other site 698970002874 D-loop; other site 698970002875 H-loop/switch region; other site 698970002876 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 698970002877 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 698970002878 putative ligand binding residues [chemical binding]; other site 698970002879 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 698970002880 phosphofructokinase; Region: PFK_mixed; TIGR02483 698970002881 active site 698970002882 ADP/pyrophosphate binding site [chemical binding]; other site 698970002883 dimerization interface [polypeptide binding]; other site 698970002884 allosteric effector site; other site 698970002885 fructose-1,6-bisphosphate binding site; other site 698970002886 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 698970002887 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 698970002888 GatB domain; Region: GatB_Yqey; smart00845 698970002889 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698970002890 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698970002891 active site 698970002892 catalytic tetrad [active] 698970002893 Lysine efflux permease [General function prediction only]; Region: COG1279 698970002894 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 698970002895 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698970002896 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698970002897 dimerization interface [polypeptide binding]; other site 698970002898 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 698970002899 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 698970002900 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 698970002901 putative dimer interface [polypeptide binding]; other site 698970002902 N-terminal domain interface [polypeptide binding]; other site 698970002903 putative substrate binding pocket (H-site) [chemical binding]; other site 698970002904 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698970002905 Predicted membrane protein [Function unknown]; Region: COG2259 698970002906 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 698970002907 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698970002908 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 698970002909 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698970002910 PYR/PP interface [polypeptide binding]; other site 698970002911 dimer interface [polypeptide binding]; other site 698970002912 TPP binding site [chemical binding]; other site 698970002913 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698970002914 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 698970002915 TPP-binding site [chemical binding]; other site 698970002916 dimer interface [polypeptide binding]; other site 698970002917 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 698970002918 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 698970002919 putative valine binding site [chemical binding]; other site 698970002920 dimer interface [polypeptide binding]; other site 698970002921 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 698970002922 ketol-acid reductoisomerase; Provisional; Region: PRK05479 698970002923 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 698970002924 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 698970002925 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 698970002926 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 698970002927 Uncharacterized conserved protein [Function unknown]; Region: COG1479 698970002928 Protein of unknown function DUF262; Region: DUF262; pfam03235 698970002929 Uncharacterized conserved protein [Function unknown]; Region: COG3472 698970002930 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 698970002931 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 698970002932 ligand binding site [chemical binding]; other site 698970002933 NAD binding site [chemical binding]; other site 698970002934 dimerization interface [polypeptide binding]; other site 698970002935 catalytic site [active] 698970002936 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 698970002937 putative L-serine binding site [chemical binding]; other site 698970002938 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 698970002939 tartrate dehydrogenase; Region: TTC; TIGR02089 698970002940 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698970002941 ligand binding site [chemical binding]; other site 698970002942 flexible hinge region; other site 698970002943 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698970002944 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698970002945 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698970002946 metal binding triad; other site 698970002947 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 698970002948 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698970002949 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698970002950 catalytic site [active] 698970002951 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 698970002952 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 698970002953 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 698970002954 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 698970002955 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698970002956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698970002957 S-adenosylmethionine binding site [chemical binding]; other site 698970002958 isochorismate synthase DhbC; Validated; Region: PRK06923 698970002959 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698970002960 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 698970002961 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698970002962 active site 698970002963 HIGH motif; other site 698970002964 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698970002965 active site 698970002966 KMSKS motif; other site 698970002967 Predicted esterase [General function prediction only]; Region: COG0400 698970002968 MMPL family; Region: MMPL; pfam03176 698970002969 Ethanolamine utilisation protein, EutH; Region: EutH; cl01248 698970002970 Cutinase; Region: Cutinase; pfam01083 698970002971 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 698970002972 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 698970002973 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 698970002974 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 698970002975 PhnA protein; Region: PhnA; pfam03831 698970002976 biotin synthase; Region: bioB; TIGR00433 698970002977 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698970002978 FeS/SAM binding site; other site 698970002979 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698970002980 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698970002981 HD domain; Region: HD_4; pfam13328 698970002982 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698970002983 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698970002984 putative DNA binding site [nucleotide binding]; other site 698970002985 putative Zn2+ binding site [ion binding]; other site 698970002986 Bacterial transcriptional regulator; Region: IclR; pfam01614 698970002987 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 698970002988 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 698970002989 substrate binding site [chemical binding]; other site 698970002990 ligand binding site [chemical binding]; other site 698970002991 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 698970002992 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 698970002993 substrate binding site [chemical binding]; other site 698970002994 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698970002995 active site 698970002996 Ap6A binding site [chemical binding]; other site 698970002997 nudix motif; other site 698970002998 metal binding site [ion binding]; metal-binding site 698970002999 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698970003000 catalytic core [active] 698970003001 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 698970003002 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698970003003 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 698970003004 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 698970003005 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 698970003006 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698970003007 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698970003008 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698970003009 thiamine monophosphate kinase; Provisional; Region: PRK05731 698970003010 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 698970003011 ATP binding site [chemical binding]; other site 698970003012 dimerization interface [polypeptide binding]; other site 698970003013 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 698970003014 ligand binding site [chemical binding]; other site 698970003015 active site 698970003016 UGI interface [polypeptide binding]; other site 698970003017 catalytic site [active] 698970003018 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 698970003019 DAK2 domain; Region: Dak2; pfam02734 698970003020 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 698970003021 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 698970003022 generic binding surface II; other site 698970003023 ssDNA binding site; other site 698970003024 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698970003025 ATP binding site [chemical binding]; other site 698970003026 putative Mg++ binding site [ion binding]; other site 698970003027 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698970003028 nucleotide binding region [chemical binding]; other site 698970003029 ATP-binding site [chemical binding]; other site 698970003030 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698970003031 carboxyltransferase (CT) interaction site; other site 698970003032 biotinylation site [posttranslational modification]; other site 698970003033 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 698970003034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698970003035 S-adenosylmethionine binding site [chemical binding]; other site 698970003036 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 698970003037 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 698970003038 active site 698970003039 (T/H)XGH motif; other site 698970003040 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698970003041 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698970003042 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698970003043 Walker A/P-loop; other site 698970003044 ATP binding site [chemical binding]; other site 698970003045 Q-loop/lid; other site 698970003046 ABC transporter signature motif; other site 698970003047 Walker B; other site 698970003048 D-loop; other site 698970003049 H-loop/switch region; other site 698970003050 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698970003051 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698970003052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698970003053 dimer interface [polypeptide binding]; other site 698970003054 conserved gate region; other site 698970003055 putative PBP binding loops; other site 698970003056 ABC-ATPase subunit interface; other site 698970003057 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698970003058 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698970003059 substrate binding pocket [chemical binding]; other site 698970003060 membrane-bound complex binding site; other site 698970003061 hinge residues; other site 698970003062 Domain of unknown function (DUF368); Region: DUF368; pfam04018 698970003063 DNA polymerase I; Provisional; Region: PRK05755 698970003064 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 698970003065 active site 698970003066 metal binding site 1 [ion binding]; metal-binding site 698970003067 putative 5' ssDNA interaction site; other site 698970003068 metal binding site 3; metal-binding site 698970003069 metal binding site 2 [ion binding]; metal-binding site 698970003070 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 698970003071 putative DNA binding site [nucleotide binding]; other site 698970003072 putative metal binding site [ion binding]; other site 698970003073 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 698970003074 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 698970003075 active site 698970003076 DNA binding site [nucleotide binding] 698970003077 catalytic site [active] 698970003078 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698970003079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698970003080 S-adenosylmethionine binding site [chemical binding]; other site 698970003081 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 698970003082 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 698970003083 RNA binding site [nucleotide binding]; other site 698970003084 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 698970003085 RNA binding site [nucleotide binding]; other site 698970003086 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698970003087 RNA binding site [nucleotide binding]; other site 698970003088 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 698970003089 RNA binding site [nucleotide binding]; other site 698970003090 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 698970003091 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 698970003092 transcriptional antiterminator BglG; Provisional; Region: PRK09772 698970003093 CAT RNA binding domain; Region: CAT_RBD; smart01061 698970003094 PRD domain; Region: PRD; pfam00874 698970003095 PRD domain; Region: PRD; pfam00874 698970003096 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 698970003097 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698970003098 active site turn [active] 698970003099 phosphorylation site [posttranslational modification] 698970003100 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698970003101 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 698970003102 HPr interaction site; other site 698970003103 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698970003104 active site 698970003105 phosphorylation site [posttranslational modification] 698970003106 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 698970003107 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 698970003108 CoA-binding site [chemical binding]; other site 698970003109 ATP-binding [chemical binding]; other site 698970003110 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 698970003111 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698970003112 FeS/SAM binding site; other site 698970003113 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 698970003114 excinuclease ABC subunit B; Provisional; Region: PRK05298 698970003115 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698970003116 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698970003117 nucleotide binding region [chemical binding]; other site 698970003118 ATP-binding site [chemical binding]; other site 698970003119 Ultra-violet resistance protein B; Region: UvrB; pfam12344 698970003120 UvrB/uvrC motif; Region: UVR; pfam02151 698970003121 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698970003122 Ligand Binding Site [chemical binding]; other site 698970003123 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 698970003124 Part of AAA domain; Region: AAA_19; pfam13245 698970003125 PhoH-like protein; Region: PhoH; cl17668 698970003126 Family description; Region: UvrD_C_2; pfam13538 698970003127 Predicted membrane protein [Function unknown]; Region: COG2259 698970003128 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698970003129 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 698970003130 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698970003131 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698970003132 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 698970003133 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 698970003134 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 698970003135 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 698970003136 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 698970003137 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 698970003138 23S rRNA binding site [nucleotide binding]; other site 698970003139 L21 binding site [polypeptide binding]; other site 698970003140 L13 binding site [polypeptide binding]; other site 698970003141 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698970003142 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 698970003143 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698970003144 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 698970003145 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 698970003146 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 698970003147 dimer interface [polypeptide binding]; other site 698970003148 motif 1; other site 698970003149 active site 698970003150 motif 2; other site 698970003151 motif 3; other site 698970003152 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 698970003153 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 698970003154 putative tRNA-binding site [nucleotide binding]; other site 698970003155 B3/4 domain; Region: B3_4; pfam03483 698970003156 tRNA synthetase B5 domain; Region: B5; smart00874 698970003157 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 698970003158 dimer interface [polypeptide binding]; other site 698970003159 motif 1; other site 698970003160 motif 3; other site 698970003161 motif 2; other site 698970003162 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 698970003163 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 698970003164 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698970003165 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 698970003166 heterotetramer interface [polypeptide binding]; other site 698970003167 active site pocket [active] 698970003168 cleavage site 698970003169 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 698970003170 feedback inhibition sensing region; other site 698970003171 homohexameric interface [polypeptide binding]; other site 698970003172 nucleotide binding site [chemical binding]; other site 698970003173 N-acetyl-L-glutamate binding site [chemical binding]; other site 698970003174 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 698970003175 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698970003176 inhibitor-cofactor binding pocket; inhibition site 698970003177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698970003178 catalytic residue [active] 698970003179 ornithine carbamoyltransferase; Provisional; Region: PRK00779 698970003180 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698970003181 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698970003182 arginine repressor; Provisional; Region: PRK03341 698970003183 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 698970003184 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 698970003185 argininosuccinate synthase; Provisional; Region: PRK13820 698970003186 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 698970003187 ANP binding site [chemical binding]; other site 698970003188 Substrate Binding Site II [chemical binding]; other site 698970003189 Substrate Binding Site I [chemical binding]; other site 698970003190 argininosuccinate lyase; Provisional; Region: PRK00855 698970003191 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 698970003192 active sites [active] 698970003193 tetramer interface [polypeptide binding]; other site 698970003194 Uncharacterized conserved protein [Function unknown]; Region: COG2835 698970003195 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 698970003196 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 698970003197 active site 698970003198 HIGH motif; other site 698970003199 dimer interface [polypeptide binding]; other site 698970003200 KMSKS motif; other site 698970003201 S4 RNA-binding domain; Region: S4; smart00363 698970003202 transcription termination factor Rho; Provisional; Region: PRK12678 698970003203 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 698970003204 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698970003205 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698970003206 active site 698970003207 motif I; other site 698970003208 motif II; other site 698970003209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698970003210 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 698970003211 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698970003212 RNA binding surface [nucleotide binding]; other site 698970003213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698970003214 S-adenosylmethionine binding site [chemical binding]; other site 698970003215 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 698970003216 ATP-NAD kinase; Region: NAD_kinase; pfam01513 698970003217 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 698970003218 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698970003219 Walker A/P-loop; other site 698970003220 ATP binding site [chemical binding]; other site 698970003221 Q-loop/lid; other site 698970003222 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698970003223 ABC transporter signature motif; other site 698970003224 Walker B; other site 698970003225 D-loop; other site 698970003226 H-loop/switch region; other site 698970003227 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 698970003228 Thiamine pyrophosphokinase; Region: TPK; cl08415 698970003229 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 698970003230 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 698970003231 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 698970003232 dimer interface [polypeptide binding]; other site 698970003233 ADP-ribose binding site [chemical binding]; other site 698970003234 active site 698970003235 nudix motif; other site 698970003236 metal binding site [ion binding]; metal-binding site 698970003237 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 698970003238 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 698970003239 active site 698970003240 Int/Topo IB signature motif; other site 698970003241 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698970003242 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698970003243 P-loop; other site 698970003244 Magnesium ion binding site [ion binding]; other site 698970003245 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698970003246 Magnesium ion binding site [ion binding]; other site 698970003247 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 698970003248 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698970003249 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 698970003250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970003251 POT family; Region: PTR2; cl17359 698970003252 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 698970003253 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698970003254 inhibitor-cofactor binding pocket; inhibition site 698970003255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698970003256 catalytic residue [active] 698970003257 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698970003258 AAA domain; Region: AAA_26; pfam13500 698970003259 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 698970003260 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 698970003261 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698970003262 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698970003263 RNA binding surface [nucleotide binding]; other site 698970003264 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 698970003265 active site 698970003266 cytidylate kinase; Provisional; Region: cmk; PRK00023 698970003267 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 698970003268 CMP-binding site; other site 698970003269 The sites determining sugar specificity; other site 698970003270 GTP-binding protein Der; Reviewed; Region: PRK03003 698970003271 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 698970003272 G1 box; other site 698970003273 GTP/Mg2+ binding site [chemical binding]; other site 698970003274 Switch I region; other site 698970003275 G2 box; other site 698970003276 Switch II region; other site 698970003277 G3 box; other site 698970003278 G4 box; other site 698970003279 G5 box; other site 698970003280 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 698970003281 G1 box; other site 698970003282 GTP/Mg2+ binding site [chemical binding]; other site 698970003283 Switch I region; other site 698970003284 G2 box; other site 698970003285 G3 box; other site 698970003286 Switch II region; other site 698970003287 G4 box; other site 698970003288 G5 box; other site 698970003289 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698970003290 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 698970003291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698970003292 S-adenosylmethionine binding site [chemical binding]; other site 698970003293 Putative esterase; Region: Esterase; pfam00756 698970003294 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698970003295 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 698970003296 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698970003297 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 698970003298 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698970003299 nucleotide binding region [chemical binding]; other site 698970003300 ATP-binding site [chemical binding]; other site 698970003301 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698970003302 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698970003303 phosphopeptide binding site; other site 698970003304 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 698970003305 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698970003306 DNA binding residues [nucleotide binding] 698970003307 Bifunctional nuclease; Region: DNase-RNase; pfam02577 698970003308 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 698970003309 DNA binding residues [nucleotide binding] 698970003310 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698970003311 putative dimer interface [polypeptide binding]; other site 698970003312 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698970003313 metal ion-dependent adhesion site (MIDAS); other site 698970003314 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698970003315 Domain of unknown function DUF21; Region: DUF21; pfam01595 698970003316 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698970003317 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698970003318 Domain of unknown function DUF21; Region: DUF21; pfam01595 698970003319 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698970003320 Transporter associated domain; Region: CorC_HlyC; smart01091 698970003321 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 698970003322 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698970003323 ATP binding site [chemical binding]; other site 698970003324 Mg++ binding site [ion binding]; other site 698970003325 motif III; other site 698970003326 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698970003327 nucleotide binding region [chemical binding]; other site 698970003328 ATP-binding site [chemical binding]; other site 698970003329 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698970003330 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 698970003331 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 698970003332 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 698970003333 CoenzymeA binding site [chemical binding]; other site 698970003334 subunit interaction site [polypeptide binding]; other site 698970003335 PHB binding site; other site 698970003336 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 698970003337 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 698970003338 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 698970003339 oligomer interface [polypeptide binding]; other site 698970003340 metal binding site [ion binding]; metal-binding site 698970003341 metal binding site [ion binding]; metal-binding site 698970003342 putative Cl binding site [ion binding]; other site 698970003343 basic sphincter; other site 698970003344 hydrophobic gate; other site 698970003345 periplasmic entrance; other site 698970003346 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698970003347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698970003348 S-adenosylmethionine binding site [chemical binding]; other site 698970003349 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698970003350 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698970003351 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698970003352 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 698970003353 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698970003354 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698970003355 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698970003356 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 698970003357 FAD binding domain; Region: FAD_binding_4; pfam01565 698970003358 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698970003359 Sodium Bile acid symporter family; Region: SBF; pfam01758 698970003360 YceI-like domain; Region: YceI; pfam04264 698970003361 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 698970003362 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 698970003363 Ligand binding site; other site 698970003364 Putative Catalytic site; other site 698970003365 DXD motif; other site 698970003366 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 698970003367 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 698970003368 putative active site [active] 698970003369 catalytic triad [active] 698970003370 putative dimer interface [polypeptide binding]; other site 698970003371 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 698970003372 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 698970003373 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698970003374 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698970003375 precorrin-3B synthase; Region: CobG; TIGR02435 698970003376 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698970003377 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698970003378 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 698970003379 Precorrin-8X methylmutase; Region: CbiC; pfam02570 698970003380 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 698970003381 active site 698970003382 SAM binding site [chemical binding]; other site 698970003383 homodimer interface [polypeptide binding]; other site 698970003384 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 698970003385 active site 698970003386 SAM binding site [chemical binding]; other site 698970003387 homodimer interface [polypeptide binding]; other site 698970003388 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 698970003389 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 698970003390 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 698970003391 active site 698970003392 SAM binding site [chemical binding]; other site 698970003393 homodimer interface [polypeptide binding]; other site 698970003394 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 698970003395 active site 698970003396 putative homodimer interface [polypeptide binding]; other site 698970003397 SAM binding site [chemical binding]; other site 698970003398 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 698970003399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698970003400 S-adenosylmethionine binding site [chemical binding]; other site 698970003401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698970003402 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698970003403 NAD(P) binding site [chemical binding]; other site 698970003404 active site 698970003405 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698970003406 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698970003407 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698970003408 active site 698970003409 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698970003410 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698970003411 ATP binding site [chemical binding]; other site 698970003412 putative Mg++ binding site [ion binding]; other site 698970003413 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698970003414 nucleotide binding region [chemical binding]; other site 698970003415 ATP-binding site [chemical binding]; other site 698970003416 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 698970003417 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 698970003418 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 698970003419 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 698970003420 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 698970003421 Predicted transcriptional regulator [Transcription]; Region: COG2378 698970003422 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 698970003423 WYL domain; Region: WYL; pfam13280 698970003424 WYL domain; Region: WYL; pfam13280 698970003425 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 698970003426 Pup-like protein; Region: Pup; pfam05639 698970003427 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 698970003428 proteasome ATPase; Region: pup_AAA; TIGR03689 698970003429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698970003430 Walker A motif; other site 698970003431 ATP binding site [chemical binding]; other site 698970003432 Walker B motif; other site 698970003433 arginine finger; other site 698970003434 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 698970003435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698970003436 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 698970003437 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 698970003438 active site 698970003439 metal binding site [ion binding]; metal-binding site 698970003440 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 698970003441 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 698970003442 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 698970003443 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 698970003444 Potassium binding sites [ion binding]; other site 698970003445 Cesium cation binding sites [ion binding]; other site 698970003446 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 698970003447 Aspartase; Region: Aspartase; cd01357 698970003448 active sites [active] 698970003449 tetramer interface [polypeptide binding]; other site 698970003450 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698970003451 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 698970003452 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 698970003453 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 698970003454 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 698970003455 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 698970003456 homodimer interface [polypeptide binding]; other site 698970003457 putative metal binding site [ion binding]; other site 698970003458 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 698970003459 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698970003460 motif II; other site 698970003461 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 698970003462 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 698970003463 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 698970003464 substrate binding pocket [chemical binding]; other site 698970003465 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 698970003466 B12 binding site [chemical binding]; other site 698970003467 cobalt ligand [ion binding]; other site 698970003468 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 698970003469 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 698970003470 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698970003471 active site 698970003472 HIGH motif; other site 698970003473 nucleotide binding site [chemical binding]; other site 698970003474 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698970003475 active site 698970003476 KMSKS motif; other site 698970003477 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698970003478 tRNA binding surface [nucleotide binding]; other site 698970003479 anticodon binding site; other site 698970003480 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 698970003481 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 698970003482 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 698970003483 quinone interaction residues [chemical binding]; other site 698970003484 active site 698970003485 catalytic residues [active] 698970003486 FMN binding site [chemical binding]; other site 698970003487 substrate binding site [chemical binding]; other site 698970003488 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 698970003489 substrate binding site [chemical binding]; other site 698970003490 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698970003491 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698970003492 HTH-like domain; Region: HTH_21; pfam13276 698970003493 Integrase core domain; Region: rve; pfam00665 698970003494 Integrase core domain; Region: rve_2; pfam13333 698970003495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698970003496 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698970003497 active site residue [active] 698970003498 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698970003499 active site residue [active] 698970003500 membrane ATPase/protein kinase; Provisional; Region: PRK09435 698970003501 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 698970003502 Walker A; other site 698970003503 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 698970003504 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 698970003505 active site 698970003506 substrate binding site [chemical binding]; other site 698970003507 coenzyme B12 binding site [chemical binding]; other site 698970003508 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 698970003509 B12 binding site [chemical binding]; other site 698970003510 cobalt ligand [ion binding]; other site 698970003511 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 698970003512 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 698970003513 heterodimer interface [polypeptide binding]; other site 698970003514 substrate interaction site [chemical binding]; other site 698970003515 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 698970003516 Uncharacterized conserved protein [Function unknown]; Region: COG0398 698970003517 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 698970003518 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698970003519 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 698970003520 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 698970003521 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 698970003522 ferrochelatase; Reviewed; Region: hemH; PRK00035 698970003523 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 698970003524 C-terminal domain interface [polypeptide binding]; other site 698970003525 active site 698970003526 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 698970003527 active site 698970003528 N-terminal domain interface [polypeptide binding]; other site 698970003529 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698970003530 NlpC/P60 family; Region: NLPC_P60; pfam00877 698970003531 aconitate hydratase; Validated; Region: PRK09277 698970003532 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698970003533 substrate binding site [chemical binding]; other site 698970003534 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698970003535 ligand binding site [chemical binding]; other site 698970003536 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 698970003537 substrate binding site [chemical binding]; other site 698970003538 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698970003539 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698970003540 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 698970003541 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 698970003542 catalytic triad [active] 698970003543 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 698970003544 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 698970003545 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698970003546 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698970003547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970003548 Walker A/P-loop; other site 698970003549 ATP binding site [chemical binding]; other site 698970003550 Q-loop/lid; other site 698970003551 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698970003552 ABC transporter signature motif; other site 698970003553 Walker B; other site 698970003554 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698970003555 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 698970003556 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 698970003557 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 698970003558 trimerization site [polypeptide binding]; other site 698970003559 active site 698970003560 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698970003561 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 698970003562 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698970003563 catalytic residue [active] 698970003564 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 698970003565 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 698970003566 Walker A/P-loop; other site 698970003567 ATP binding site [chemical binding]; other site 698970003568 Q-loop/lid; other site 698970003569 ABC transporter signature motif; other site 698970003570 Walker B; other site 698970003571 D-loop; other site 698970003572 H-loop/switch region; other site 698970003573 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 698970003574 FeS assembly protein SufD; Region: sufD; TIGR01981 698970003575 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 698970003576 FeS assembly protein SufB; Region: sufB; TIGR01980 698970003577 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698970003578 Predicted transcriptional regulator [Transcription]; Region: COG2345 698970003579 putative DNA binding site [nucleotide binding]; other site 698970003580 putative Zn2+ binding site [ion binding]; other site 698970003581 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698970003582 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698970003583 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698970003584 Walker A/P-loop; other site 698970003585 ATP binding site [chemical binding]; other site 698970003586 Q-loop/lid; other site 698970003587 ABC transporter signature motif; other site 698970003588 Walker B; other site 698970003589 D-loop; other site 698970003590 H-loop/switch region; other site 698970003591 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698970003592 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698970003593 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 698970003594 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 698970003595 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 698970003596 UbiA prenyltransferase family; Region: UbiA; pfam01040 698970003597 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 698970003598 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 698970003599 TPP-binding site [chemical binding]; other site 698970003600 dimer interface [polypeptide binding]; other site 698970003601 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698970003602 PYR/PP interface [polypeptide binding]; other site 698970003603 dimer interface [polypeptide binding]; other site 698970003604 TPP binding site [chemical binding]; other site 698970003605 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698970003606 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 698970003607 putative active site [active] 698970003608 transaldolase; Provisional; Region: PRK03903 698970003609 catalytic residue [active] 698970003610 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 698970003611 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 698970003612 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 698970003613 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 698970003614 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 698970003615 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698970003616 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 698970003617 putative active site [active] 698970003618 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 698970003619 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 698970003620 triosephosphate isomerase; Provisional; Region: PRK14567 698970003621 substrate binding site [chemical binding]; other site 698970003622 dimer interface [polypeptide binding]; other site 698970003623 catalytic triad [active] 698970003624 Phosphoglycerate kinase; Region: PGK; pfam00162 698970003625 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 698970003626 substrate binding site [chemical binding]; other site 698970003627 hinge regions; other site 698970003628 ADP binding site [chemical binding]; other site 698970003629 catalytic site [active] 698970003630 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 698970003631 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 698970003632 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698970003633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 698970003634 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 698970003635 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 698970003636 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 698970003637 phosphate binding site [ion binding]; other site 698970003638 putative substrate binding pocket [chemical binding]; other site 698970003639 dimer interface [polypeptide binding]; other site 698970003640 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 698970003641 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 698970003642 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 698970003643 GIY-YIG motif/motif A; other site 698970003644 active site 698970003645 catalytic site [active] 698970003646 putative DNA binding site [nucleotide binding]; other site 698970003647 metal binding site [ion binding]; metal-binding site 698970003648 UvrB/uvrC motif; Region: UVR; pfam02151 698970003649 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 698970003650 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698970003651 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 698970003652 homopentamer interface [polypeptide binding]; other site 698970003653 active site 698970003654 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 698970003655 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 698970003656 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 698970003657 dimerization interface [polypeptide binding]; other site 698970003658 active site 698970003659 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 698970003660 Lumazine binding domain; Region: Lum_binding; pfam00677 698970003661 Lumazine binding domain; Region: Lum_binding; pfam00677 698970003662 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 698970003663 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 698970003664 catalytic motif [active] 698970003665 Zn binding site [ion binding]; other site 698970003666 RibD C-terminal domain; Region: RibD_C; pfam01872 698970003667 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 698970003668 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 698970003669 substrate binding site [chemical binding]; other site 698970003670 hexamer interface [polypeptide binding]; other site 698970003671 metal binding site [ion binding]; metal-binding site 698970003672 16S rRNA methyltransferase B; Provisional; Region: PRK14902 698970003673 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 698970003674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698970003675 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 698970003676 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 698970003677 putative active site [active] 698970003678 substrate binding site [chemical binding]; other site 698970003679 putative cosubstrate binding site; other site 698970003680 catalytic site [active] 698970003681 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 698970003682 substrate binding site [chemical binding]; other site 698970003683 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698970003684 active site 698970003685 catalytic residues [active] 698970003686 metal binding site [ion binding]; metal-binding site 698970003687 primosome assembly protein PriA; Provisional; Region: PRK14873 698970003688 S-adenosylmethionine synthetase; Validated; Region: PRK05250 698970003689 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 698970003690 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 698970003691 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 698970003692 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 698970003693 Flavoprotein; Region: Flavoprotein; pfam02441 698970003694 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 698970003695 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 698970003696 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 698970003697 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 698970003698 catalytic site [active] 698970003699 G-X2-G-X-G-K; other site 698970003700 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 698970003701 active site 698970003702 dimer interface [polypeptide binding]; other site 698970003703 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 698970003704 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698970003705 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698970003706 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 698970003707 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698970003708 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698970003709 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 698970003710 IMP binding site; other site 698970003711 dimer interface [polypeptide binding]; other site 698970003712 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 698970003713 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 698970003714 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 698970003715 catalytic site [active] 698970003716 subunit interface [polypeptide binding]; other site 698970003717 dihydroorotase; Validated; Region: pyrC; PRK09357 698970003718 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698970003719 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 698970003720 active site 698970003721 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 698970003722 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698970003723 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698970003724 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 698970003725 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698970003726 active site 698970003727 hydrophobic ligand binding site; other site 698970003728 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698970003729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698970003730 TIGR01777 family protein; Region: yfcH 698970003731 NAD(P) binding site [chemical binding]; other site 698970003732 active site 698970003733 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 698970003734 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 698970003735 elongation factor P; Validated; Region: PRK00529 698970003736 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 698970003737 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 698970003738 RNA binding site [nucleotide binding]; other site 698970003739 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 698970003740 RNA binding site [nucleotide binding]; other site 698970003741 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698970003742 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698970003743 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698970003744 active site 698970003745 Dehydroquinase class II; Region: DHquinase_II; pfam01220 698970003746 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 698970003747 trimer interface [polypeptide binding]; other site 698970003748 active site 698970003749 dimer interface [polypeptide binding]; other site 698970003750 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 698970003751 active site 698970003752 dimer interface [polypeptide binding]; other site 698970003753 metal binding site [ion binding]; metal-binding site 698970003754 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 698970003755 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 698970003756 ADP binding site [chemical binding]; other site 698970003757 magnesium binding site [ion binding]; other site 698970003758 putative shikimate binding site; other site 698970003759 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 698970003760 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 698970003761 Tetramer interface [polypeptide binding]; other site 698970003762 active site 698970003763 FMN-binding site [chemical binding]; other site 698970003764 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 698970003765 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698970003766 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698970003767 shikimate binding site; other site 698970003768 NAD(P) binding site [chemical binding]; other site 698970003769 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 698970003770 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 698970003771 dimerization interface [polypeptide binding]; other site 698970003772 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 698970003773 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 698970003774 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 698970003775 motif 1; other site 698970003776 active site 698970003777 motif 2; other site 698970003778 motif 3; other site 698970003779 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698970003780 DHHA1 domain; Region: DHHA1; pfam02272 698970003781 recombination factor protein RarA; Reviewed; Region: PRK13342 698970003782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698970003783 Walker A motif; other site 698970003784 ATP binding site [chemical binding]; other site 698970003785 Walker B motif; other site 698970003786 arginine finger; other site 698970003787 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 698970003788 Phosphotransferase enzyme family; Region: APH; pfam01636 698970003789 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698970003790 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 698970003791 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 698970003792 dimer interface [polypeptide binding]; other site 698970003793 anticodon binding site; other site 698970003794 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 698970003795 homodimer interface [polypeptide binding]; other site 698970003796 motif 1; other site 698970003797 active site 698970003798 motif 2; other site 698970003799 GAD domain; Region: GAD; pfam02938 698970003800 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698970003801 active site 698970003802 motif 3; other site 698970003803 Predicted metalloprotease [General function prediction only]; Region: COG2321 698970003804 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 698970003805 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698970003806 ATP binding site [chemical binding]; other site 698970003807 putative Mg++ binding site [ion binding]; other site 698970003808 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698970003809 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 698970003810 nucleotide binding region [chemical binding]; other site 698970003811 ATP-binding site [chemical binding]; other site 698970003812 Predicted membrane protein [Function unknown]; Region: COG1511 698970003813 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698970003814 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698970003815 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698970003816 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698970003817 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698970003818 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970003819 Q-loop/lid; other site 698970003820 ABC transporter signature motif; other site 698970003821 Walker B; other site 698970003822 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698970003823 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698970003824 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698970003825 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698970003826 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698970003827 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 698970003828 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 698970003829 dimer interface [polypeptide binding]; other site 698970003830 motif 1; other site 698970003831 active site 698970003832 motif 2; other site 698970003833 motif 3; other site 698970003834 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 698970003835 anticodon binding site; other site 698970003836 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698970003837 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 698970003838 dimer interface [polypeptide binding]; other site 698970003839 catalytic triad [active] 698970003840 peroxidatic and resolving cysteines [active] 698970003841 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698970003842 active site 698970003843 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698970003844 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698970003845 Zn2+ binding site [ion binding]; other site 698970003846 Mg2+ binding site [ion binding]; other site 698970003847 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698970003848 synthetase active site [active] 698970003849 NTP binding site [chemical binding]; other site 698970003850 metal binding site [ion binding]; metal-binding site 698970003851 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 698970003852 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 698970003853 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698970003854 active site 698970003855 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 698970003856 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698970003857 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 698970003858 Protein export membrane protein; Region: SecD_SecF; cl14618 698970003859 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 698970003860 Protein export membrane protein; Region: SecD_SecF; cl14618 698970003861 Preprotein translocase subunit; Region: YajC; pfam02699 698970003862 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 698970003863 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698970003864 Walker A motif; other site 698970003865 ATP binding site [chemical binding]; other site 698970003866 Walker B motif; other site 698970003867 arginine finger; other site 698970003868 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 698970003869 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 698970003870 RuvA N terminal domain; Region: RuvA_N; pfam01330 698970003871 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 698970003872 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 698970003873 active site 698970003874 putative DNA-binding cleft [nucleotide binding]; other site 698970003875 dimer interface [polypeptide binding]; other site 698970003876 hypothetical protein; Validated; Region: PRK00110 698970003877 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 698970003878 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 698970003879 active site 698970003880 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 698970003881 catalytic triad [active] 698970003882 dimer interface [polypeptide binding]; other site 698970003883 HTH-like domain; Region: HTH_21; pfam13276 698970003884 Integrase core domain; Region: rve; pfam00665 698970003885 potential frameshift: common BLAST hit: gi|336115754|ref|YP_004570520.1| transposase 698970003886 Helix-turn-helix domain; Region: HTH_38; pfam13936 698970003887 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698970003888 Integrase core domain; Region: rve; pfam00665 698970003889 Integrase core domain; Region: rve_3; cl15866 698970003890 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 698970003891 Nitronate monooxygenase; Region: NMO; pfam03060 698970003892 FMN binding site [chemical binding]; other site 698970003893 substrate binding site [chemical binding]; other site 698970003894 putative catalytic residue [active] 698970003895 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 698970003896 Replicase family; Region: Replicase; pfam03090 698970003897 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 698970003898 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698970003899 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698970003900 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698970003901 catalytic residues [active] 698970003902 catalytic nucleophile [active] 698970003903 Presynaptic Site I dimer interface [polypeptide binding]; other site 698970003904 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698970003905 Synaptic Flat tetramer interface [polypeptide binding]; other site 698970003906 Synaptic Site I dimer interface [polypeptide binding]; other site 698970003907 DNA binding site [nucleotide binding] 698970003908 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698970003909 MULE transposase domain; Region: MULE; pfam10551 698970003910 potential frameshift: common BLAST hit: gi|68536874|ref|YP_251579.1| transposase IS3525 698970003911 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698970003912 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698970003913 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698970003914 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 698970003915 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 698970003916 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698970003917 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698970003918 catalytic residue [active] 698970003919 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698970003920 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698970003921 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 698970003922 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 698970003923 putative acyl-acceptor binding pocket; other site 698970003924 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698970003925 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 698970003926 nucleotide binding site/active site [active] 698970003927 HIT family signature motif; other site 698970003928 catalytic residue [active] 698970003929 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 698970003930 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698970003931 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 698970003932 active site 698970003933 dimer interface [polypeptide binding]; other site 698970003934 motif 1; other site 698970003935 motif 2; other site 698970003936 motif 3; other site 698970003937 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 698970003938 anticodon binding site; other site 698970003939 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 698970003940 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 698970003941 Protein of unknown function (DUF461); Region: DUF461; pfam04314 698970003942 CopC domain; Region: CopC; cl01012 698970003943 hypothetical protein; Provisional; Region: PRK14059 698970003944 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 698970003945 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 698970003946 SelR domain; Region: SelR; pfam01641 698970003947 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 698970003948 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 698970003949 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 698970003950 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 698970003951 catalytic site [active] 698970003952 putative active site [active] 698970003953 putative substrate binding site [chemical binding]; other site 698970003954 HRDC domain; Region: HRDC; pfam00570 698970003955 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 698970003956 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 698970003957 TPP-binding site; other site 698970003958 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698970003959 PYR/PP interface [polypeptide binding]; other site 698970003960 dimer interface [polypeptide binding]; other site 698970003961 TPP binding site [chemical binding]; other site 698970003962 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698970003963 TRAM domain; Region: TRAM; cl01282 698970003964 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 698970003965 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 698970003966 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698970003967 trimer interface [polypeptide binding]; other site 698970003968 active site 698970003969 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 698970003970 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 698970003971 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 698970003972 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698970003973 active site 698970003974 dimerization interface [polypeptide binding]; other site 698970003975 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698970003976 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698970003977 nucleotide binding site [chemical binding]; other site 698970003978 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698970003979 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698970003980 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698970003981 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698970003982 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698970003983 DNA binding residues [nucleotide binding] 698970003984 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698970003985 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698970003986 ATP binding site [chemical binding]; other site 698970003987 putative Mg++ binding site [ion binding]; other site 698970003988 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 698970003989 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 698970003990 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 698970003991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698970003992 S-adenosylmethionine binding site [chemical binding]; other site 698970003993 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 698970003994 dimerization interface [polypeptide binding]; other site 698970003995 putative tRNAtyr binding site [nucleotide binding]; other site 698970003996 putative active site [active] 698970003997 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698970003998 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698970003999 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698970004000 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698970004001 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698970004002 DNA binding residues [nucleotide binding] 698970004003 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698970004004 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698970004005 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698970004006 FeoA domain; Region: FeoA; cl00838 698970004007 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 698970004008 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 698970004009 NAD binding site [chemical binding]; other site 698970004010 homodimer interface [polypeptide binding]; other site 698970004011 active site 698970004012 substrate binding site [chemical binding]; other site 698970004013 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 698970004014 PAC2 family; Region: PAC2; pfam09754 698970004015 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698970004016 ATP binding site [chemical binding]; other site 698970004017 putative Mg++ binding site [ion binding]; other site 698970004018 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698970004019 nucleotide binding region [chemical binding]; other site 698970004020 ATP-binding site [chemical binding]; other site 698970004021 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 698970004022 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 698970004023 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 698970004024 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698970004025 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 698970004026 dimer interface [polypeptide binding]; other site 698970004027 decamer (pentamer of dimers) interface [polypeptide binding]; other site 698970004028 catalytic triad [active] 698970004029 peroxidatic and resolving cysteines [active] 698970004030 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698970004031 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 698970004032 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 698970004033 dimerization interface [polypeptide binding]; other site 698970004034 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 698970004035 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698970004036 ATP binding site [chemical binding]; other site 698970004037 putative Mg++ binding site [ion binding]; other site 698970004038 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698970004039 nucleotide binding region [chemical binding]; other site 698970004040 ATP-binding site [chemical binding]; other site 698970004041 Helicase associated domain (HA2); Region: HA2; pfam04408 698970004042 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 698970004043 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 698970004044 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 698970004045 ATP cone domain; Region: ATP-cone; pfam03477 698970004046 LexA repressor; Validated; Region: PRK00215 698970004047 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 698970004048 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698970004049 Catalytic site [active] 698970004050 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698970004051 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 698970004052 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698970004053 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 698970004054 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 698970004055 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 698970004056 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 698970004057 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698970004058 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698970004059 DNA-binding site [nucleotide binding]; DNA binding site 698970004060 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698970004061 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 698970004062 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 698970004063 putative substrate binding site [chemical binding]; other site 698970004064 putative ATP binding site [chemical binding]; other site 698970004065 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698970004066 dimerization domain swap beta strand [polypeptide binding]; other site 698970004067 regulatory protein interface [polypeptide binding]; other site 698970004068 active site 698970004069 regulatory phosphorylation site [posttranslational modification]; other site 698970004070 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 698970004071 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698970004072 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 698970004073 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698970004074 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 698970004075 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 698970004076 GTPases [General function prediction only]; Region: HflX; COG2262 698970004077 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 698970004078 HflX GTPase family; Region: HflX; cd01878 698970004079 G1 box; other site 698970004080 GTP/Mg2+ binding site [chemical binding]; other site 698970004081 Switch I region; other site 698970004082 G2 box; other site 698970004083 G3 box; other site 698970004084 Switch II region; other site 698970004085 G4 box; other site 698970004086 G5 box; other site 698970004087 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 698970004088 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698970004089 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698970004090 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 698970004091 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 698970004092 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698970004093 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698970004094 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698970004095 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698970004096 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 698970004097 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 698970004098 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698970004099 FeS/SAM binding site; other site 698970004100 recombination regulator RecX; Reviewed; Region: recX; PRK00117 698970004101 recombinase A; Provisional; Region: recA; PRK09354 698970004102 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 698970004103 hexamer interface [polypeptide binding]; other site 698970004104 Walker A motif; other site 698970004105 ATP binding site [chemical binding]; other site 698970004106 Walker B motif; other site 698970004107 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 698970004108 BioY family; Region: BioY; pfam02632 698970004109 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698970004110 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698970004111 Walker A/P-loop; other site 698970004112 ATP binding site [chemical binding]; other site 698970004113 Q-loop/lid; other site 698970004114 ABC transporter signature motif; other site 698970004115 Walker B; other site 698970004116 D-loop; other site 698970004117 H-loop/switch region; other site 698970004118 Cobalt transport protein; Region: CbiQ; cl00463 698970004119 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698970004120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698970004121 sequence-specific DNA binding site [nucleotide binding]; other site 698970004122 salt bridge; other site 698970004123 Competence-damaged protein; Region: CinA; pfam02464 698970004124 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698970004125 YCII-related domain; Region: YCII; cl00999 698970004126 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 698970004127 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 698970004128 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698970004129 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 698970004130 TIGR03085 family protein; Region: TIGR03085 698970004131 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 698970004132 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698970004133 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 698970004134 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 698970004135 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698970004136 dimer interface [polypeptide binding]; other site 698970004137 active site 698970004138 catalytic residue [active] 698970004139 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 698970004140 dihydrodipicolinate reductase; Provisional; Region: PRK00048 698970004141 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 698970004142 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 698970004143 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 698970004144 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 698970004145 oligomer interface [polypeptide binding]; other site 698970004146 RNA binding site [nucleotide binding]; other site 698970004147 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 698970004148 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 698970004149 RNase E interface [polypeptide binding]; other site 698970004150 trimer interface [polypeptide binding]; other site 698970004151 active site 698970004152 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 698970004153 putative nucleic acid binding region [nucleotide binding]; other site 698970004154 G-X-X-G motif; other site 698970004155 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 698970004156 RNA binding site [nucleotide binding]; other site 698970004157 domain interface; other site 698970004158 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 698970004159 16S/18S rRNA binding site [nucleotide binding]; other site 698970004160 S13e-L30e interaction site [polypeptide binding]; other site 698970004161 25S rRNA binding site [nucleotide binding]; other site 698970004162 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 698970004163 active site 698970004164 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 698970004165 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 698970004166 active site 698970004167 Riboflavin kinase; Region: Flavokinase; smart00904 698970004168 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 698970004169 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 698970004170 RNA binding site [nucleotide binding]; other site 698970004171 active site 698970004172 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 698970004173 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 698970004174 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 698970004175 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698970004176 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698970004177 active site 698970004178 metal binding site [ion binding]; metal-binding site 698970004179 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698970004180 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 698970004181 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 698970004182 DHH family; Region: DHH; pfam01368 698970004183 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 698970004184 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698970004185 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698970004186 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 698970004187 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 698970004188 G1 box; other site 698970004189 putative GEF interaction site [polypeptide binding]; other site 698970004190 GTP/Mg2+ binding site [chemical binding]; other site 698970004191 Switch I region; other site 698970004192 G2 box; other site 698970004193 G3 box; other site 698970004194 Switch II region; other site 698970004195 G4 box; other site 698970004196 G5 box; other site 698970004197 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 698970004198 Translation-initiation factor 2; Region: IF-2; pfam11987 698970004199 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 698970004200 Protein of unknown function (DUF448); Region: DUF448; pfam04296 698970004201 putative RNA binding cleft [nucleotide binding]; other site 698970004202 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 698970004203 NusA N-terminal domain; Region: NusA_N; pfam08529 698970004204 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 698970004205 RNA binding site [nucleotide binding]; other site 698970004206 homodimer interface [polypeptide binding]; other site 698970004207 NusA-like KH domain; Region: KH_5; pfam13184 698970004208 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 698970004209 G-X-X-G motif; other site 698970004210 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 698970004211 Sm and related proteins; Region: Sm_like; cl00259 698970004212 prolyl-tRNA synthetase; Provisional; Region: PRK09194 698970004213 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 698970004214 dimer interface [polypeptide binding]; other site 698970004215 motif 1; other site 698970004216 active site 698970004217 motif 2; other site 698970004218 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 698970004219 putative deacylase active site [active] 698970004220 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698970004221 active site 698970004222 motif 3; other site 698970004223 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 698970004224 anticodon binding site; other site 698970004225 hypothetical protein; Validated; Region: PRK02101 698970004226 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 698970004227 active site 698970004228 SAM binding site [chemical binding]; other site 698970004229 homodimer interface [polypeptide binding]; other site 698970004230 Uncharacterized conserved protein [Function unknown]; Region: COG0397 698970004231 hypothetical protein; Validated; Region: PRK00029 698970004232 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698970004233 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 698970004234 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 698970004235 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 698970004236 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 698970004237 DNA binding site [nucleotide binding] 698970004238 active site 698970004239 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 698970004240 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698970004241 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 698970004242 catalytic triad [active] 698970004243 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 698970004244 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 698970004245 Walker A motif; other site 698970004246 homodimer interface [polypeptide binding]; other site 698970004247 ATP binding site [chemical binding]; other site 698970004248 hydroxycobalamin binding site [chemical binding]; other site 698970004249 Walker B motif; other site 698970004250 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 698970004251 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 698970004252 metal ion-dependent adhesion site (MIDAS); other site 698970004253 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 698970004254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698970004255 Walker A motif; other site 698970004256 ATP binding site [chemical binding]; other site 698970004257 Walker B motif; other site 698970004258 arginine finger; other site 698970004259 malate:quinone oxidoreductase; Validated; Region: PRK05257 698970004260 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 698970004261 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698970004262 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698970004263 mycothione reductase; Region: mycothione_red; TIGR03452 698970004264 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698970004265 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698970004266 cobyric acid synthase; Provisional; Region: PRK00784 698970004267 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 698970004268 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698970004269 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698970004270 catalytic triad [active] 698970004271 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698970004272 active site 698970004273 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 698970004274 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698970004275 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 698970004276 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698970004277 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698970004278 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 698970004279 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698970004280 active site 698970004281 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 698970004282 protein binding site [polypeptide binding]; other site 698970004283 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 698970004284 putative substrate binding region [chemical binding]; other site 698970004285 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 698970004286 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 698970004287 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 698970004288 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 698970004289 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 698970004290 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 698970004291 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698970004292 FeS/SAM binding site; other site 698970004293 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 698970004294 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 698970004295 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 698970004296 ribosome recycling factor; Reviewed; Region: frr; PRK00083 698970004297 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 698970004298 hinge region; other site 698970004299 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 698970004300 putative nucleotide binding site [chemical binding]; other site 698970004301 uridine monophosphate binding site [chemical binding]; other site 698970004302 homohexameric interface [polypeptide binding]; other site 698970004303 elongation factor Ts; Provisional; Region: tsf; PRK09377 698970004304 UBA/TS-N domain; Region: UBA; pfam00627 698970004305 Elongation factor TS; Region: EF_TS; pfam00889 698970004306 Elongation factor TS; Region: EF_TS; pfam00889 698970004307 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 698970004308 rRNA interaction site [nucleotide binding]; other site 698970004309 S8 interaction site; other site 698970004310 putative laminin-1 binding site; other site 698970004311 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698970004312 Peptidase family M23; Region: Peptidase_M23; pfam01551 698970004313 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698970004314 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 698970004315 active site 698970004316 DNA binding site [nucleotide binding] 698970004317 Int/Topo IB signature motif; other site 698970004318 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 698970004319 DNA protecting protein DprA; Region: dprA; TIGR00732 698970004320 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 698970004321 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 698970004322 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698970004323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698970004324 Walker A motif; other site 698970004325 ATP binding site [chemical binding]; other site 698970004326 Walker B motif; other site 698970004327 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 698970004328 hypothetical protein; Reviewed; Region: PRK12497 698970004329 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 698970004330 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 698970004331 RNA/DNA hybrid binding site [nucleotide binding]; other site 698970004332 active site 698970004333 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 698970004334 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698970004335 Catalytic site [active] 698970004336 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698970004337 Htaa; Region: HtaA; pfam04213 698970004338 Htaa; Region: HtaA; pfam04213 698970004339 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 698970004340 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 698970004341 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 698970004342 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 698970004343 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698970004344 RNA binding site [nucleotide binding]; other site 698970004345 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 698970004346 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 698970004347 RimM N-terminal domain; Region: RimM; pfam01782 698970004348 PRC-barrel domain; Region: PRC; pfam05239 698970004349 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 698970004350 signal recognition particle protein; Provisional; Region: PRK10867 698970004351 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 698970004352 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 698970004353 P loop; other site 698970004354 GTP binding site [chemical binding]; other site 698970004355 Signal peptide binding domain; Region: SRP_SPB; pfam02978 698970004356 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 698970004357 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698970004358 metal binding triad; other site 698970004359 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698970004360 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 698970004361 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 698970004362 Nitrogen regulatory protein P-II; Region: P-II; smart00938 698970004363 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 698970004364 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 698970004365 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 698970004366 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698970004367 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 698970004368 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698970004369 Walker A/P-loop; other site 698970004370 ATP binding site [chemical binding]; other site 698970004371 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 698970004372 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698970004373 ABC transporter signature motif; other site 698970004374 Walker B; other site 698970004375 D-loop; other site 698970004376 H-loop/switch region; other site 698970004377 Acylphosphatase; Region: Acylphosphatase; cl00551 698970004378 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698970004379 amino acid carrier protein; Region: agcS; TIGR00835 698970004380 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 698970004381 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 698970004382 DNA binding site [nucleotide binding] 698970004383 catalytic residue [active] 698970004384 H2TH interface [polypeptide binding]; other site 698970004385 putative catalytic residues [active] 698970004386 turnover-facilitating residue; other site 698970004387 intercalation triad [nucleotide binding]; other site 698970004388 8OG recognition residue [nucleotide binding]; other site 698970004389 putative reading head residues; other site 698970004390 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698970004391 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698970004392 ribonuclease III; Reviewed; Region: rnc; PRK00102 698970004393 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 698970004394 dimerization interface [polypeptide binding]; other site 698970004395 active site 698970004396 metal binding site [ion binding]; metal-binding site 698970004397 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 698970004398 dsRNA binding site [nucleotide binding]; other site 698970004399 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 698970004400 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698970004401 glutamate dehydrogenase; Provisional; Region: PRK09414 698970004402 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 698970004403 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 698970004404 NAD(P) binding site [chemical binding]; other site 698970004405 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 698970004406 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698970004407 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698970004408 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 698970004409 metal binding site [ion binding]; metal-binding site 698970004410 putative dimer interface [polypeptide binding]; other site 698970004411 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 698970004412 homodimer interface [polypeptide binding]; other site 698970004413 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 698970004414 active site pocket [active] 698970004415 pyruvate kinase; Provisional; Region: PRK06247 698970004416 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 698970004417 domain interfaces; other site 698970004418 active site 698970004419 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 698970004420 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698970004421 active site 698970004422 ribulose/triose binding site [chemical binding]; other site 698970004423 phosphate binding site [ion binding]; other site 698970004424 substrate (anthranilate) binding pocket [chemical binding]; other site 698970004425 product (indole) binding pocket [chemical binding]; other site 698970004426 trp region conserved hypothetical membrane protein; Region: trp_oprn_chp; TIGR02234 698970004427 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 698970004428 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 698970004429 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698970004430 substrate binding site [chemical binding]; other site 698970004431 glutamase interaction surface [polypeptide binding]; other site 698970004432 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698970004433 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698970004434 active site 698970004435 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 698970004436 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698970004437 catalytic residues [active] 698970004438 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 698970004439 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 698970004440 putative active site [active] 698970004441 oxyanion strand; other site 698970004442 catalytic triad [active] 698970004443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970004444 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698970004445 putative substrate translocation pore; other site 698970004446 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 698970004447 putative active site pocket [active] 698970004448 4-fold oligomerization interface [polypeptide binding]; other site 698970004449 metal binding residues [ion binding]; metal-binding site 698970004450 3-fold/trimer interface [polypeptide binding]; other site 698970004451 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 698970004452 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698970004453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698970004454 homodimer interface [polypeptide binding]; other site 698970004455 catalytic residue [active] 698970004456 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 698970004457 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 698970004458 NAD binding site [chemical binding]; other site 698970004459 dimerization interface [polypeptide binding]; other site 698970004460 product binding site; other site 698970004461 substrate binding site [chemical binding]; other site 698970004462 zinc binding site [ion binding]; other site 698970004463 catalytic residues [active] 698970004464 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 698970004465 tetracycline repressor protein TetR; Provisional; Region: PRK13756 698970004466 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698970004467 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 698970004468 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 698970004469 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 698970004470 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 698970004471 active site 698970004472 catalytic site [active] 698970004473 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 698970004474 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 698970004475 active site 698970004476 catalytic site [active] 698970004477 substrate binding site [chemical binding]; other site 698970004478 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698970004479 synthetase active site [active] 698970004480 NTP binding site [chemical binding]; other site 698970004481 metal binding site [ion binding]; metal-binding site 698970004482 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698970004483 RNA binding surface [nucleotide binding]; other site 698970004484 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 698970004485 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 698970004486 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 698970004487 threonine dehydratase; Validated; Region: PRK08639 698970004488 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698970004489 tetramer interface [polypeptide binding]; other site 698970004490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698970004491 catalytic residue [active] 698970004492 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 698970004493 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 698970004494 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 698970004495 active site 698970004496 PHP Thumb interface [polypeptide binding]; other site 698970004497 metal binding site [ion binding]; metal-binding site 698970004498 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698970004499 generic binding surface II; other site 698970004500 generic binding surface I; other site 698970004501 Predicted permeases [General function prediction only]; Region: RarD; COG2962 698970004502 EamA-like transporter family; Region: EamA; cl17759 698970004503 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 698970004504 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698970004505 RNA binding surface [nucleotide binding]; other site 698970004506 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698970004507 active site 698970004508 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 698970004509 lipoprotein signal peptidase; Provisional; Region: PRK14787 698970004510 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698970004511 active site 698970004512 homotetramer interface [polypeptide binding]; other site 698970004513 homodimer interface [polypeptide binding]; other site 698970004514 DNA polymerase IV; Provisional; Region: PRK03348 698970004515 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 698970004516 active site 698970004517 DNA binding site [nucleotide binding] 698970004518 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 698970004519 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698970004520 HIGH motif; other site 698970004521 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698970004522 active site 698970004523 KMSKS motif; other site 698970004524 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 698970004525 tRNA binding surface [nucleotide binding]; other site 698970004526 anticodon binding site; other site 698970004527 DivIVA domain; Region: DivI1A_domain; TIGR03544 698970004528 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698970004529 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 698970004530 YGGT family; Region: YGGT; cl00508 698970004531 Protein of unknown function (DUF552); Region: DUF552; cl00775 698970004532 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 698970004533 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 698970004534 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 698970004535 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 698970004536 nucleotide binding site [chemical binding]; other site 698970004537 SulA interaction site; other site 698970004538 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 698970004539 Cell division protein FtsQ; Region: FtsQ; pfam03799 698970004540 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 698970004541 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698970004542 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698970004543 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698970004544 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 698970004545 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 698970004546 active site 698970004547 homodimer interface [polypeptide binding]; other site 698970004548 cell division protein FtsW; Region: ftsW; TIGR02614 698970004549 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 698970004550 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698970004551 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698970004552 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 698970004553 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 698970004554 Mg++ binding site [ion binding]; other site 698970004555 putative catalytic motif [active] 698970004556 putative substrate binding site [chemical binding]; other site 698970004557 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 698970004558 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698970004559 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698970004560 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698970004561 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 698970004562 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698970004563 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698970004564 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698970004565 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698970004566 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698970004567 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698970004568 MraW methylase family; Region: Methyltransf_5; cl17771 698970004569 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 698970004570 cell division protein MraZ; Reviewed; Region: PRK00326 698970004571 MraZ protein; Region: MraZ; pfam02381 698970004572 MraZ protein; Region: MraZ; pfam02381 698970004573 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 698970004574 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698970004575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698970004576 Coenzyme A binding pocket [chemical binding]; other site 698970004577 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 698970004578 FAD binding site [chemical binding]; other site 698970004579 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698970004580 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698970004581 substrate binding pocket [chemical binding]; other site 698970004582 chain length determination region; other site 698970004583 substrate-Mg2+ binding site; other site 698970004584 catalytic residues [active] 698970004585 aspartate-rich region 1; other site 698970004586 active site lid residues [active] 698970004587 aspartate-rich region 2; other site 698970004588 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698970004589 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698970004590 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698970004591 active site 698970004592 ATP binding site [chemical binding]; other site 698970004593 substrate binding site [chemical binding]; other site 698970004594 activation loop (A-loop); other site 698970004595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698970004596 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698970004597 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698970004598 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698970004599 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698970004600 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 698970004601 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698970004602 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698970004603 putative acyl-acceptor binding pocket; other site 698970004604 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698970004605 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698970004606 nucleotide binding site [chemical binding]; other site 698970004607 Tesmin/TSO1-like CXC domain; Region: CXC; pfam03638 698970004608 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698970004609 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698970004610 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698970004611 NlpC/P60 family; Region: NLPC_P60; pfam00877 698970004612 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698970004613 NlpC/P60 family; Region: NLPC_P60; pfam00877 698970004614 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 698970004615 heme bH binding site [chemical binding]; other site 698970004616 intrachain domain interface; other site 698970004617 heme bL binding site [chemical binding]; other site 698970004618 interchain domain interface [polypeptide binding]; other site 698970004619 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 698970004620 Qo binding site; other site 698970004621 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 698970004622 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698970004623 iron-sulfur cluster [ion binding]; other site 698970004624 [2Fe-2S] cluster binding site [ion binding]; other site 698970004625 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698970004626 Cytochrome c; Region: Cytochrom_C; pfam00034 698970004627 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698970004628 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 698970004629 Subunit I/III interface [polypeptide binding]; other site 698970004630 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 698970004631 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 698970004632 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 698970004633 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 698970004634 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 698970004635 active site 698970004636 dimer interface [polypeptide binding]; other site 698970004637 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 698970004638 Ligand Binding Site [chemical binding]; other site 698970004639 Molecular Tunnel; other site 698970004640 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 698970004641 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 698970004642 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 698970004643 homotrimer interface [polypeptide binding]; other site 698970004644 Walker A motif; other site 698970004645 GTP binding site [chemical binding]; other site 698970004646 Walker B motif; other site 698970004647 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 698970004648 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 698970004649 putative dimer interface [polypeptide binding]; other site 698970004650 active site pocket [active] 698970004651 putative cataytic base [active] 698970004652 cobalamin synthase; Reviewed; Region: cobS; PRK00235 698970004653 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 698970004654 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 698970004655 homodimer interface [polypeptide binding]; other site 698970004656 substrate-cofactor binding pocket; other site 698970004657 catalytic residue [active] 698970004658 multifunctional aminopeptidase A; Provisional; Region: PRK00913 698970004659 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 698970004660 interface (dimer of trimers) [polypeptide binding]; other site 698970004661 Substrate-binding/catalytic site; other site 698970004662 Zn-binding sites [ion binding]; other site 698970004663 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 698970004664 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698970004665 E3 interaction surface; other site 698970004666 lipoyl attachment site [posttranslational modification]; other site 698970004667 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698970004668 E3 interaction surface; other site 698970004669 lipoyl attachment site [posttranslational modification]; other site 698970004670 e3 binding domain; Region: E3_binding; pfam02817 698970004671 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698970004672 lipoate-protein ligase B; Provisional; Region: PRK14345 698970004673 lipoyl synthase; Provisional; Region: PRK05481 698970004674 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698970004675 FeS/SAM binding site; other site 698970004676 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 698970004677 RDD family; Region: RDD; pfam06271 698970004678 glutamine synthetase, type I; Region: GlnA; TIGR00653 698970004679 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698970004680 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698970004681 Predicted peptidase [General function prediction only]; Region: COG4099 698970004682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 698970004683 Predicted permease [General function prediction only]; Region: COG2056 698970004684 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 698970004685 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698970004686 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698970004687 DNA-binding site [nucleotide binding]; DNA binding site 698970004688 FCD domain; Region: FCD; pfam07729 698970004689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970004690 putative substrate translocation pore; other site 698970004691 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 698970004692 nudix motif; other site 698970004693 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 698970004694 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 698970004695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698970004696 catalytic residue [active] 698970004697 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 698970004698 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 698970004699 heme binding pocket [chemical binding]; other site 698970004700 heme ligand [chemical binding]; other site 698970004701 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 698970004702 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698970004703 metal binding triad; other site 698970004704 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698970004705 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698970004706 metal binding triad; other site 698970004707 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698970004708 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 698970004709 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698970004710 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698970004711 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 698970004712 putative active site; other site 698970004713 putative metal binding residues [ion binding]; other site 698970004714 signature motif; other site 698970004715 putative triphosphate binding site [ion binding]; other site 698970004716 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 698970004717 galactokinase; Provisional; Region: PRK00555 698970004718 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698970004719 potential frameshift: common BLAST hit: gi|300858911|ref|YP_003783894.1| ribonuclease R 698970004720 RNB domain; Region: RNB; pfam00773 698970004721 Predicted membrane protein [General function prediction only]; Region: COG4194 698970004722 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 698970004723 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 698970004724 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 698970004725 RNA/DNA hybrid binding site [nucleotide binding]; other site 698970004726 active site 698970004727 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698970004728 catalytic core [active] 698970004729 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 698970004730 Putative zinc ribbon domain; Region: DUF164; pfam02591 698970004731 Uncharacterized conserved protein [Function unknown]; Region: COG0327 698970004732 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698970004733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 698970004734 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698970004735 hypothetical protein; Provisional; Region: PRK07908 698970004736 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698970004737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698970004738 homodimer interface [polypeptide binding]; other site 698970004739 catalytic residue [active] 698970004740 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 698970004741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698970004742 motif II; other site 698970004743 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 698970004744 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 698970004745 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 698970004746 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 698970004747 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 698970004748 dimer interface [polypeptide binding]; other site 698970004749 TPP-binding site [chemical binding]; other site 698970004750 Electron transfer DM13; Region: DM13; pfam10517 698970004751 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698970004752 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698970004753 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698970004754 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 698970004755 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698970004756 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698970004757 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698970004758 active site 698970004759 motif I; other site 698970004760 motif II; other site 698970004761 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698970004762 motif II; other site 698970004763 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698970004764 Beta-lactamase; Region: Beta-lactamase; pfam00144 698970004765 Predicted membrane protein [Function unknown]; Region: COG2860 698970004766 UPF0126 domain; Region: UPF0126; pfam03458 698970004767 UPF0126 domain; Region: UPF0126; pfam03458 698970004768 DNA primase; Validated; Region: dnaG; PRK05667 698970004769 CHC2 zinc finger; Region: zf-CHC2; pfam01807 698970004770 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 698970004771 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 698970004772 active site 698970004773 metal binding site [ion binding]; metal-binding site 698970004774 interdomain interaction site; other site 698970004775 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 698970004776 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 698970004777 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 698970004778 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 698970004779 glutaminase active site [active] 698970004780 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698970004781 dimer interface [polypeptide binding]; other site 698970004782 active site 698970004783 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 698970004784 dimer interface [polypeptide binding]; other site 698970004785 active site 698970004786 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 698970004787 active site 698970004788 barstar interaction site; other site 698970004789 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 698970004790 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698970004791 Zn2+ binding site [ion binding]; other site 698970004792 Mg2+ binding site [ion binding]; other site 698970004793 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 698970004794 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698970004795 putative active site [active] 698970004796 Repair protein; Region: Repair_PSII; pfam04536 698970004797 glycyl-tRNA synthetase; Provisional; Region: PRK04173 698970004798 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698970004799 motif 1; other site 698970004800 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 698970004801 active site 698970004802 motif 2; other site 698970004803 motif 3; other site 698970004804 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 698970004805 anticodon binding site; other site 698970004806 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698970004807 putative DNA binding site [nucleotide binding]; other site 698970004808 dimerization interface [polypeptide binding]; other site 698970004809 putative Zn2+ binding site [ion binding]; other site 698970004810 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698970004811 metal binding site 2 [ion binding]; metal-binding site 698970004812 putative DNA binding helix; other site 698970004813 metal binding site 1 [ion binding]; metal-binding site 698970004814 dimer interface [polypeptide binding]; other site 698970004815 structural Zn2+ binding site [ion binding]; other site 698970004816 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 698970004817 diiron binding motif [ion binding]; other site 698970004818 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 698970004819 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698970004820 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 698970004821 catalytic residue [active] 698970004822 putative FPP diphosphate binding site; other site 698970004823 putative FPP binding hydrophobic cleft; other site 698970004824 dimer interface [polypeptide binding]; other site 698970004825 putative IPP diphosphate binding site; other site 698970004826 Recombination protein O N terminal; Region: RecO_N; pfam11967 698970004827 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 698970004828 Recombination protein O C terminal; Region: RecO_C; pfam02565 698970004829 GTPase Era; Reviewed; Region: era; PRK00089 698970004830 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 698970004831 G1 box; other site 698970004832 GTP/Mg2+ binding site [chemical binding]; other site 698970004833 Switch I region; other site 698970004834 G2 box; other site 698970004835 Switch II region; other site 698970004836 G3 box; other site 698970004837 G4 box; other site 698970004838 G5 box; other site 698970004839 KH domain; Region: KH_2; pfam07650 698970004840 pyridoxamine kinase; Validated; Region: PRK05756 698970004841 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 698970004842 dimer interface [polypeptide binding]; other site 698970004843 pyridoxal binding site [chemical binding]; other site 698970004844 ATP binding site [chemical binding]; other site 698970004845 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698970004846 Domain of unknown function DUF21; Region: DUF21; pfam01595 698970004847 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698970004848 Transporter associated domain; Region: CorC_HlyC; smart01091 698970004849 metal-binding heat shock protein; Provisional; Region: PRK00016 698970004850 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 698970004851 PhoH-like protein; Region: PhoH; pfam02562 698970004852 RNA methyltransferase, RsmE family; Region: TIGR00046 698970004853 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 698970004854 chaperone protein DnaJ; Provisional; Region: PRK14278 698970004855 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698970004856 HSP70 interaction site [polypeptide binding]; other site 698970004857 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698970004858 Zn binding sites [ion binding]; other site 698970004859 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698970004860 dimer interface [polypeptide binding]; other site 698970004861 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 698970004862 coproporphyrinogen III oxidase; Validated; Region: PRK05628 698970004863 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698970004864 FeS/SAM binding site; other site 698970004865 HemN C-terminal domain; Region: HemN_C; pfam06969 698970004866 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698970004867 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698970004868 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698970004869 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698970004870 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 698970004871 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 698970004872 acyl-activating enzyme (AAE) consensus motif; other site 698970004873 putative AMP binding site [chemical binding]; other site 698970004874 putative active site [active] 698970004875 putative CoA binding site [chemical binding]; other site 698970004876 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 698970004877 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 698970004878 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 698970004879 active site 698970004880 Zn binding site [ion binding]; other site 698970004881 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698970004882 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698970004883 substrate binding pocket [chemical binding]; other site 698970004884 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 698970004885 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 698970004886 active site 698970004887 metal binding site [ion binding]; metal-binding site 698970004888 nudix motif; other site 698970004889 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698970004890 active site 698970004891 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698970004892 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698970004893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970004894 Walker A/P-loop; other site 698970004895 ATP binding site [chemical binding]; other site 698970004896 Q-loop/lid; other site 698970004897 ABC transporter signature motif; other site 698970004898 Walker B; other site 698970004899 D-loop; other site 698970004900 H-loop/switch region; other site 698970004901 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 698970004902 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698970004903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698970004904 homodimer interface [polypeptide binding]; other site 698970004905 catalytic residue [active] 698970004906 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 698970004907 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698970004908 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 698970004909 BCCT family transporter; Region: BCCT; pfam02028 698970004910 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698970004911 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 698970004912 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698970004913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698970004914 dimer interface [polypeptide binding]; other site 698970004915 conserved gate region; other site 698970004916 putative PBP binding loops; other site 698970004917 ABC-ATPase subunit interface; other site 698970004918 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698970004919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698970004920 dimer interface [polypeptide binding]; other site 698970004921 conserved gate region; other site 698970004922 putative PBP binding loops; other site 698970004923 ABC-ATPase subunit interface; other site 698970004924 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698970004925 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698970004926 Walker A/P-loop; other site 698970004927 ATP binding site [chemical binding]; other site 698970004928 Q-loop/lid; other site 698970004929 ABC transporter signature motif; other site 698970004930 Walker B; other site 698970004931 D-loop; other site 698970004932 H-loop/switch region; other site 698970004933 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698970004934 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698970004935 Walker A/P-loop; other site 698970004936 ATP binding site [chemical binding]; other site 698970004937 Q-loop/lid; other site 698970004938 ABC transporter signature motif; other site 698970004939 Walker B; other site 698970004940 D-loop; other site 698970004941 H-loop/switch region; other site 698970004942 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698970004943 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 698970004944 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 698970004945 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698970004946 catalytic residue [active] 698970004947 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698970004948 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698970004949 nucleotide binding site [chemical binding]; other site 698970004950 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 698970004951 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698970004952 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698970004953 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 698970004954 active site residue [active] 698970004955 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 698970004956 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698970004957 TrkA-N domain; Region: TrkA_N; pfam02254 698970004958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970004959 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 698970004960 active site 698970004961 tetramer interface [polypeptide binding]; other site 698970004962 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 698970004963 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698970004964 Mrr N-terminal domain; Region: Mrr_N; pfam14338 698970004965 Restriction endonuclease; Region: Mrr_cat; pfam04471 698970004966 Abi-like protein; Region: Abi_2; pfam07751 698970004967 GTP-binding protein LepA; Provisional; Region: PRK05433 698970004968 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 698970004969 G1 box; other site 698970004970 putative GEF interaction site [polypeptide binding]; other site 698970004971 GTP/Mg2+ binding site [chemical binding]; other site 698970004972 Switch I region; other site 698970004973 G2 box; other site 698970004974 G3 box; other site 698970004975 Switch II region; other site 698970004976 G4 box; other site 698970004977 G5 box; other site 698970004978 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 698970004979 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 698970004980 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 698970004981 PemK-like protein; Region: PemK; pfam02452 698970004982 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 698970004983 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698970004984 hypothetical protein; Validated; Region: PRK05629 698970004985 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 698970004986 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 698970004987 Competence protein; Region: Competence; pfam03772 698970004988 comEA protein; Region: comE; TIGR01259 698970004989 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 698970004990 helix-hairpin-helix signature motif; other site 698970004991 EDD domain protein, DegV family; Region: DegV; TIGR00762 698970004992 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 698970004993 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698970004994 catalytic core [active] 698970004995 Oligomerisation domain; Region: Oligomerisation; cl00519 698970004996 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 698970004997 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 698970004998 active site 698970004999 (T/H)XGH motif; other site 698970005000 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 698970005001 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 698970005002 putative catalytic cysteine [active] 698970005003 gamma-glutamyl kinase; Provisional; Region: PRK05429 698970005004 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 698970005005 nucleotide binding site [chemical binding]; other site 698970005006 homotetrameric interface [polypeptide binding]; other site 698970005007 putative phosphate binding site [ion binding]; other site 698970005008 putative allosteric binding site; other site 698970005009 PUA domain; Region: PUA; pfam01472 698970005010 GTPase CgtA; Reviewed; Region: obgE; PRK12296 698970005011 GTP1/OBG; Region: GTP1_OBG; pfam01018 698970005012 Obg GTPase; Region: Obg; cd01898 698970005013 G1 box; other site 698970005014 GTP/Mg2+ binding site [chemical binding]; other site 698970005015 Switch I region; other site 698970005016 G2 box; other site 698970005017 G3 box; other site 698970005018 Switch II region; other site 698970005019 G4 box; other site 698970005020 G5 box; other site 698970005021 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 698970005022 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 698970005023 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 698970005024 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 698970005025 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698970005026 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 698970005027 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 698970005028 homodimer interface [polypeptide binding]; other site 698970005029 oligonucleotide binding site [chemical binding]; other site 698970005030 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 698970005031 active site 698970005032 multimer interface [polypeptide binding]; other site 698970005033 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 698970005034 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 698970005035 dimer interface [polypeptide binding]; other site 698970005036 active site 698970005037 CoA binding pocket [chemical binding]; other site 698970005038 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698970005039 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 698970005040 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698970005041 catalytic residue [active] 698970005042 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698970005043 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698970005044 active site 698970005045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970005046 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698970005047 Resolvase, N terminal domain; Region: Resolvase; pfam00239 698970005048 potential frameshift: common BLAST hit: gi|336115754|ref|YP_004570520.1| transposase 698970005049 Helix-turn-helix domain; Region: HTH_38; pfam13936 698970005050 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698970005051 Integrase core domain; Region: rve; pfam00665 698970005052 Integrase core domain; Region: rve_3; pfam13683 698970005053 potential frameshift: common BLAST hit: gi|68535288|ref|YP_249993.1| transposase IS3510a 698970005054 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698970005055 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698970005056 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 698970005057 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 698970005058 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698970005059 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 698970005060 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698970005061 active site 698970005062 HIGH motif; other site 698970005063 nucleotide binding site [chemical binding]; other site 698970005064 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698970005065 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 698970005066 active site 698970005067 KMSKS motif; other site 698970005068 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 698970005069 tRNA binding surface [nucleotide binding]; other site 698970005070 anticodon binding site; other site 698970005071 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 698970005072 malate dehydrogenase; Provisional; Region: PRK05442 698970005073 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 698970005074 NAD(P) binding site [chemical binding]; other site 698970005075 dimer interface [polypeptide binding]; other site 698970005076 malate binding site [chemical binding]; other site 698970005077 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698970005078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698970005079 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 698970005080 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 698970005081 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 698970005082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698970005083 Walker A motif; other site 698970005084 ATP binding site [chemical binding]; other site 698970005085 Walker B motif; other site 698970005086 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 698970005087 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698970005088 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698970005089 glutamine binding [chemical binding]; other site 698970005090 catalytic triad [active] 698970005091 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 698970005092 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698970005093 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 698970005094 substrate-cofactor binding pocket; other site 698970005095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698970005096 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 698970005097 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698970005098 oligomer interface [polypeptide binding]; other site 698970005099 active site residues [active] 698970005100 Clp protease; Region: CLP_protease; pfam00574 698970005101 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698970005102 oligomer interface [polypeptide binding]; other site 698970005103 active site residues [active] 698970005104 trigger factor; Provisional; Region: tig; PRK01490 698970005105 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698970005106 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 698970005107 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 698970005108 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698970005109 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698970005110 catalytic residues [active] 698970005111 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 698970005112 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 698970005113 Zn binding site [ion binding]; other site 698970005114 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698970005115 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698970005116 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 698970005117 apolar tunnel; other site 698970005118 heme binding site [chemical binding]; other site 698970005119 dimerization interface [polypeptide binding]; other site 698970005120 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698970005121 active site 698970005122 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 698970005123 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970005124 Walker A/P-loop; other site 698970005125 ATP binding site [chemical binding]; other site 698970005126 Q-loop/lid; other site 698970005127 ABC transporter signature motif; other site 698970005128 Walker B; other site 698970005129 D-loop; other site 698970005130 H-loop/switch region; other site 698970005131 ABC transporter; Region: ABC_tran_2; pfam12848 698970005132 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698970005133 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698970005134 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698970005135 dimer interface [polypeptide binding]; other site 698970005136 ssDNA binding site [nucleotide binding]; other site 698970005137 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698970005138 Copper resistance protein D; Region: CopD; pfam05425 698970005139 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 698970005140 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 698970005141 Carbon starvation protein CstA; Region: CstA; pfam02554 698970005142 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 698970005143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970005144 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698970005145 putative substrate translocation pore; other site 698970005146 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 698970005147 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 698970005148 NADP binding site [chemical binding]; other site 698970005149 dimer interface [polypeptide binding]; other site 698970005150 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698970005151 classical (c) SDRs; Region: SDR_c; cd05233 698970005152 NAD(P) binding site [chemical binding]; other site 698970005153 active site 698970005154 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 698970005155 catalytic site [active] 698970005156 putative active site [active] 698970005157 putative substrate binding site [chemical binding]; other site 698970005158 dimer interface [polypeptide binding]; other site 698970005159 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698970005160 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698970005161 inhibitor site; inhibition site 698970005162 active site 698970005163 dimer interface [polypeptide binding]; other site 698970005164 catalytic residue [active] 698970005165 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 698970005166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698970005167 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 698970005168 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698970005169 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 698970005170 conserved cis-peptide bond; other site 698970005171 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 698970005172 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 698970005173 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698970005174 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 698970005175 catalytic triad [active] 698970005176 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698970005177 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698970005178 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 698970005179 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698970005180 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 698970005181 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698970005182 phosphate binding site [ion binding]; other site 698970005183 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 698970005184 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 698970005185 active site 2 [active] 698970005186 active site 1 [active] 698970005187 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 698970005188 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698970005189 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 698970005190 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 698970005191 putative NAD(P) binding site [chemical binding]; other site 698970005192 active site 698970005193 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 698970005194 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 698970005195 active site 698970005196 Glucitol operon activator protein (GutM); Region: GutM; cl01890 698970005197 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 698970005198 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 698970005199 active site 698970005200 dimerization interface [polypeptide binding]; other site 698970005201 ribonuclease PH; Reviewed; Region: rph; PRK00173 698970005202 Ribonuclease PH; Region: RNase_PH_bact; cd11362 698970005203 hexamer interface [polypeptide binding]; other site 698970005204 active site 698970005205 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 698970005206 glutamate racemase; Provisional; Region: PRK00865 698970005207 Rhomboid family; Region: Rhomboid; cl11446 698970005208 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 698970005209 putative active site pocket [active] 698970005210 cleavage site 698970005211 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 698970005212 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 698970005213 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 698970005214 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 698970005215 active site 698970005216 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 698970005217 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698970005218 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698970005219 putative Mg++ binding site [ion binding]; other site 698970005220 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 698970005221 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698970005222 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 698970005223 Integrase core domain; Region: rve; pfam00665 698970005224 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698970005225 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698970005226 Presynaptic Site I dimer interface [polypeptide binding]; other site 698970005227 catalytic residues [active] 698970005228 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698970005229 Synaptic Flat tetramer interface [polypeptide binding]; other site 698970005230 Synaptic Site I dimer interface [polypeptide binding]; other site 698970005231 DNA binding site [nucleotide binding] 698970005232 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 698970005233 DNA-binding interface [nucleotide binding]; DNA binding site 698970005234 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698970005235 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698970005236 HTH-like domain; Region: HTH_21; pfam13276 698970005237 Integrase core domain; Region: rve; pfam00665 698970005238 Integrase core domain; Region: rve_2; pfam13333 698970005239 potential frameshift: common BLAST hit: gi|68536877|ref|YP_251582.1| transposase IS3508i 698970005240 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698970005241 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698970005242 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 698970005243 dimer interface [polypeptide binding]; other site 698970005244 putative active site [active] 698970005245 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 698970005246 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 698970005247 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 698970005248 phosphoserine phosphatase SerB; Region: serB; TIGR00338 698970005249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698970005250 motif II; other site 698970005251 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 698970005252 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 698970005253 D-pathway; other site 698970005254 Putative ubiquinol binding site [chemical binding]; other site 698970005255 Low-spin heme (heme b) binding site [chemical binding]; other site 698970005256 Putative water exit pathway; other site 698970005257 Binuclear center (heme o3/CuB) [ion binding]; other site 698970005258 K-pathway; other site 698970005259 Putative proton exit pathway; other site 698970005260 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698970005261 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698970005262 dimer interface [polypeptide binding]; other site 698970005263 putative radical transfer pathway; other site 698970005264 diiron center [ion binding]; other site 698970005265 tyrosyl radical; other site 698970005266 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 698970005267 Ferritin-like domain; Region: Ferritin; pfam00210 698970005268 ferroxidase diiron center [ion binding]; other site 698970005269 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 698970005270 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 698970005271 Class I ribonucleotide reductase; Region: RNR_I; cd01679 698970005272 active site 698970005273 dimer interface [polypeptide binding]; other site 698970005274 catalytic residues [active] 698970005275 effector binding site; other site 698970005276 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698970005277 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698970005278 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698970005279 catalytic residues [active] 698970005280 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 698970005281 active site lid residues [active] 698970005282 substrate binding pocket [chemical binding]; other site 698970005283 catalytic residues [active] 698970005284 substrate-Mg2+ binding site; other site 698970005285 aspartate-rich region 1; other site 698970005286 aspartate-rich region 2; other site 698970005287 phytoene desaturase; Region: crtI_fam; TIGR02734 698970005288 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698970005289 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 698970005290 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 698970005291 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 698970005292 homodimer interface [polypeptide binding]; other site 698970005293 NAD binding pocket [chemical binding]; other site 698970005294 ATP binding pocket [chemical binding]; other site 698970005295 Mg binding site [ion binding]; other site 698970005296 active-site loop [active] 698970005297 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 698970005298 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 698970005299 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 698970005300 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 698970005301 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 698970005302 Predicted transcriptional regulator [Transcription]; Region: COG2345 698970005303 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 698970005304 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698970005305 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 698970005306 catalytic residues [active] 698970005307 Methylamine utilisation protein MauE; Region: MauE; pfam07291 698970005308 phosphoglucomutase; Validated; Region: PRK07564 698970005309 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 698970005310 active site 698970005311 substrate binding site [chemical binding]; other site 698970005312 metal binding site [ion binding]; metal-binding site 698970005313 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134 698970005314 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698970005315 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698970005316 FtsX-like permease family; Region: FtsX; pfam02687 698970005317 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698970005318 FtsX-like permease family; Region: FtsX; pfam02687 698970005319 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698970005320 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698970005321 Walker A/P-loop; other site 698970005322 ATP binding site [chemical binding]; other site 698970005323 Q-loop/lid; other site 698970005324 ABC transporter signature motif; other site 698970005325 Walker B; other site 698970005326 D-loop; other site 698970005327 H-loop/switch region; other site 698970005328 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698970005329 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698970005330 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698970005331 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698970005332 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698970005333 hinge; other site 698970005334 active site 698970005335 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 698970005336 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 698970005337 GAF domain; Region: GAF_2; pfam13185 698970005338 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698970005339 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698970005340 DNA binding residues [nucleotide binding] 698970005341 dimerization interface [polypeptide binding]; other site 698970005342 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698970005343 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698970005344 dimer interface [polypeptide binding]; other site 698970005345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698970005346 catalytic residue [active] 698970005347 serine O-acetyltransferase; Region: cysE; TIGR01172 698970005348 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 698970005349 trimer interface [polypeptide binding]; other site 698970005350 active site 698970005351 substrate binding site [chemical binding]; other site 698970005352 CoA binding site [chemical binding]; other site 698970005353 Predicted acetyltransferase [General function prediction only]; Region: COG2388 698970005354 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 698970005355 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 698970005356 putative active site [active] 698970005357 metal binding site [ion binding]; metal-binding site 698970005358 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698970005359 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 698970005360 DNA methylase; Region: N6_N4_Mtase; pfam01555 698970005361 DNA methylase; Region: N6_N4_Mtase; pfam01555 698970005362 HTH-like domain; Region: HTH_21; pfam13276 698970005363 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 698970005364 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 698970005365 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698970005366 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698970005367 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 698970005368 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 698970005369 Walker A/P-loop; other site 698970005370 ATP binding site [chemical binding]; other site 698970005371 Q-loop/lid; other site 698970005372 ABC transporter signature motif; other site 698970005373 Walker B; other site 698970005374 D-loop; other site 698970005375 H-loop/switch region; other site 698970005376 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 698970005377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970005378 Walker A/P-loop; other site 698970005379 ATP binding site [chemical binding]; other site 698970005380 Q-loop/lid; other site 698970005381 ABC transporter signature motif; other site 698970005382 Walker B; other site 698970005383 D-loop; other site 698970005384 H-loop/switch region; other site 698970005385 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 698970005386 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 698970005387 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 698970005388 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 698970005389 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 698970005390 FMN binding site [chemical binding]; other site 698970005391 active site 698970005392 catalytic residues [active] 698970005393 substrate binding site [chemical binding]; other site 698970005394 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 698970005395 PhoU domain; Region: PhoU; pfam01895 698970005396 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 698970005397 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698970005398 Coenzyme A binding pocket [chemical binding]; other site 698970005399 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698970005400 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698970005401 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 698970005402 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 698970005403 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 698970005404 heme-binding site [chemical binding]; other site 698970005405 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 698970005406 substrate binding site [chemical binding]; other site 698970005407 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 698970005408 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 698970005409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698970005410 catalytic residue [active] 698970005411 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 698970005412 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 698970005413 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698970005414 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 698970005415 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 698970005416 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 698970005417 dimerization interface [polypeptide binding]; other site 698970005418 putative ATP binding site [chemical binding]; other site 698970005419 amidophosphoribosyltransferase; Provisional; Region: PRK07847 698970005420 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 698970005421 active site 698970005422 tetramer interface [polypeptide binding]; other site 698970005423 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698970005424 active site 698970005425 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 698970005426 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 698970005427 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698970005428 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698970005429 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698970005430 dimer interface [polypeptide binding]; other site 698970005431 putative radical transfer pathway; other site 698970005432 diiron center [ion binding]; other site 698970005433 tyrosyl radical; other site 698970005434 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 698970005435 catalytic residues [active] 698970005436 dimer interface [polypeptide binding]; other site 698970005437 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 698970005438 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698970005439 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 698970005440 ATP binding site [chemical binding]; other site 698970005441 active site 698970005442 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 698970005443 substrate binding site [chemical binding]; other site 698970005444 adenylosuccinate lyase; Region: purB; TIGR00928 698970005445 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 698970005446 tetramer interface [polypeptide binding]; other site 698970005447 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698970005448 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698970005449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698970005450 homodimer interface [polypeptide binding]; other site 698970005451 catalytic residue [active] 698970005452 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 698970005453 TrkA-N domain; Region: TrkA_N; pfam02254 698970005454 TrkA-C domain; Region: TrkA_C; pfam02080 698970005455 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 698970005456 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 698970005457 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 698970005458 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 698970005459 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 698970005460 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 698970005461 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 698970005462 nucleotide binding site/active site [active] 698970005463 HIT family signature motif; other site 698970005464 catalytic residue [active] 698970005465 PGAP1-like protein; Region: PGAP1; pfam07819 698970005466 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698970005467 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698970005468 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698970005469 dimerization interface [polypeptide binding]; other site 698970005470 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698970005471 dimer interface [polypeptide binding]; other site 698970005472 phosphorylation site [posttranslational modification] 698970005473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698970005474 ATP binding site [chemical binding]; other site 698970005475 Mg2+ binding site [ion binding]; other site 698970005476 G-X-G motif; other site 698970005477 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698970005478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698970005479 active site 698970005480 phosphorylation site [posttranslational modification] 698970005481 intermolecular recognition site; other site 698970005482 dimerization interface [polypeptide binding]; other site 698970005483 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698970005484 DNA binding site [nucleotide binding] 698970005485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970005486 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698970005487 putative substrate translocation pore; other site 698970005488 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698970005489 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698970005490 xanthine permease; Region: pbuX; TIGR03173 698970005491 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 698970005492 pyruvate dehydrogenase; Provisional; Region: PRK06546 698970005493 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 698970005494 PYR/PP interface [polypeptide binding]; other site 698970005495 dimer interface [polypeptide binding]; other site 698970005496 tetramer interface [polypeptide binding]; other site 698970005497 TPP binding site [chemical binding]; other site 698970005498 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698970005499 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 698970005500 TPP-binding site [chemical binding]; other site 698970005501 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698970005502 Uncharacterized conserved protein [Function unknown]; Region: COG3610 698970005503 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698970005504 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698970005505 Uncharacterized conserved protein [Function unknown]; Region: COG3610 698970005506 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 698970005507 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 698970005508 active site 698970005509 homotetramer interface [polypeptide binding]; other site 698970005510 META domain; Region: META; cl01245 698970005511 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 698970005512 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 698970005513 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698970005514 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698970005515 DNA binding site [nucleotide binding] 698970005516 domain linker motif; other site 698970005517 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 698970005518 putative dimerization interface [polypeptide binding]; other site 698970005519 putative ligand binding site [chemical binding]; other site 698970005520 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698970005521 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 698970005522 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698970005523 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 698970005524 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698970005525 active site 698970005526 HIGH motif; other site 698970005527 nucleotide binding site [chemical binding]; other site 698970005528 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698970005529 KMSKS motif; other site 698970005530 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698970005531 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 698970005532 homotrimer interaction site [polypeptide binding]; other site 698970005533 zinc binding site [ion binding]; other site 698970005534 CDP-binding sites; other site 698970005535 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 698970005536 substrate binding site; other site 698970005537 dimer interface; other site 698970005538 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 698970005539 DNA repair protein RadA; Provisional; Region: PRK11823 698970005540 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698970005541 Walker A motif; other site 698970005542 ATP binding site [chemical binding]; other site 698970005543 Walker B motif; other site 698970005544 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698970005545 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 698970005546 active site clefts [active] 698970005547 zinc binding site [ion binding]; other site 698970005548 dimer interface [polypeptide binding]; other site 698970005549 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698970005550 endonuclease III; Region: ENDO3c; smart00478 698970005551 minor groove reading motif; other site 698970005552 helix-hairpin-helix signature motif; other site 698970005553 substrate binding pocket [chemical binding]; other site 698970005554 active site 698970005555 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698970005556 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 698970005557 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 698970005558 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 698970005559 Clp amino terminal domain; Region: Clp_N; pfam02861 698970005560 Clp amino terminal domain; Region: Clp_N; pfam02861 698970005561 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698970005562 Walker A motif; other site 698970005563 ATP binding site [chemical binding]; other site 698970005564 Walker B motif; other site 698970005565 arginine finger; other site 698970005566 UvrB/uvrC motif; Region: UVR; pfam02151 698970005567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698970005568 Walker A motif; other site 698970005569 ATP binding site [chemical binding]; other site 698970005570 Walker B motif; other site 698970005571 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698970005572 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 698970005573 oligomer interface [polypeptide binding]; other site 698970005574 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698970005575 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698970005576 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 698970005577 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698970005578 dimer interface [polypeptide binding]; other site 698970005579 putative anticodon binding site; other site 698970005580 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698970005581 motif 1; other site 698970005582 dimer interface [polypeptide binding]; other site 698970005583 active site 698970005584 motif 2; other site 698970005585 motif 3; other site 698970005586 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698970005587 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 698970005588 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698970005589 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698970005590 Walker A/P-loop; other site 698970005591 ATP binding site [chemical binding]; other site 698970005592 Q-loop/lid; other site 698970005593 ABC transporter signature motif; other site 698970005594 Walker B; other site 698970005595 D-loop; other site 698970005596 H-loop/switch region; other site 698970005597 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698970005598 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698970005599 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698970005600 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 698970005601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 698970005602 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698970005603 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698970005604 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698970005605 active site 698970005606 KMSKS motif; other site 698970005607 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 698970005608 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 698970005609 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 698970005610 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 698970005611 catalytic center binding site [active] 698970005612 ATP binding site [chemical binding]; other site 698970005613 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 698970005614 homooctamer interface [polypeptide binding]; other site 698970005615 active site 698970005616 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698970005617 dihydropteroate synthase; Region: DHPS; TIGR01496 698970005618 substrate binding pocket [chemical binding]; other site 698970005619 dimer interface [polypeptide binding]; other site 698970005620 inhibitor binding site; inhibition site 698970005621 Protein of unknown function, DUF393; Region: DUF393; pfam04134 698970005622 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 698970005623 homodecamer interface [polypeptide binding]; other site 698970005624 GTP cyclohydrolase I; Provisional; Region: PLN03044 698970005625 active site 698970005626 putative catalytic site residues [active] 698970005627 zinc binding site [ion binding]; other site 698970005628 GTP-CH-I/GFRP interaction surface; other site 698970005629 FtsH Extracellular; Region: FtsH_ext; pfam06480 698970005630 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 698970005631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698970005632 Walker A motif; other site 698970005633 ATP binding site [chemical binding]; other site 698970005634 Walker B motif; other site 698970005635 arginine finger; other site 698970005636 Peptidase family M41; Region: Peptidase_M41; pfam01434 698970005637 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698970005638 active site 698970005639 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 698970005640 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 698970005641 Ligand Binding Site [chemical binding]; other site 698970005642 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 698970005643 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 698970005644 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 698970005645 dimer interface [polypeptide binding]; other site 698970005646 substrate binding site [chemical binding]; other site 698970005647 metal binding sites [ion binding]; metal-binding site 698970005648 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698970005649 active site residue [active] 698970005650 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698970005651 MarR family; Region: MarR_2; pfam12802 698970005652 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698970005653 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 698970005654 acyl-activating enzyme (AAE) consensus motif; other site 698970005655 AMP binding site [chemical binding]; other site 698970005656 active site 698970005657 CoA binding site [chemical binding]; other site 698970005658 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698970005659 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 698970005660 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698970005661 putative trimer interface [polypeptide binding]; other site 698970005662 putative CoA binding site [chemical binding]; other site 698970005663 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698970005664 putative trimer interface [polypeptide binding]; other site 698970005665 putative CoA binding site [chemical binding]; other site 698970005666 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698970005667 metal ion-dependent adhesion site (MIDAS); other site 698970005668 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698970005669 active site 698970005670 catalytic site [active] 698970005671 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698970005672 Secretory lipase; Region: LIP; pfam03583 698970005673 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698970005674 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 698970005675 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698970005676 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698970005677 ring oligomerisation interface [polypeptide binding]; other site 698970005678 ATP/Mg binding site [chemical binding]; other site 698970005679 stacking interactions; other site 698970005680 hinge regions; other site 698970005681 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 698970005682 hypothetical protein; Reviewed; Region: PRK09588 698970005683 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 698970005684 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 698970005685 FMN binding site [chemical binding]; other site 698970005686 active site 698970005687 substrate binding site [chemical binding]; other site 698970005688 catalytic residue [active] 698970005689 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 698970005690 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698970005691 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698970005692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970005693 Walker A/P-loop; other site 698970005694 ATP binding site [chemical binding]; other site 698970005695 Q-loop/lid; other site 698970005696 ABC transporter signature motif; other site 698970005697 Walker B; other site 698970005698 D-loop; other site 698970005699 H-loop/switch region; other site 698970005700 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698970005701 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 698970005702 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698970005703 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698970005704 Walker A/P-loop; other site 698970005705 ATP binding site [chemical binding]; other site 698970005706 Q-loop/lid; other site 698970005707 ABC transporter signature motif; other site 698970005708 Walker B; other site 698970005709 D-loop; other site 698970005710 H-loop/switch region; other site 698970005711 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698970005712 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698970005713 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698970005714 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 698970005715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 698970005716 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698970005717 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698970005718 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698970005719 active site 698970005720 KMSKS motif; other site 698970005721 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 698970005722 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 698970005723 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 698970005724 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 698970005725 catalytic center binding site [active] 698970005726 ATP binding site [chemical binding]; other site 698970005727 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 698970005728 homooctamer interface [polypeptide binding]; other site 698970005729 active site 698970005730 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698970005731 dihydropteroate synthase; Region: DHPS; TIGR01496 698970005732 substrate binding pocket [chemical binding]; other site 698970005733 dimer interface [polypeptide binding]; other site 698970005734 inhibitor binding site; inhibition site 698970005735 Protein of unknown function, DUF393; Region: DUF393; pfam04134 698970005736 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 698970005737 homodecamer interface [polypeptide binding]; other site 698970005738 GTP cyclohydrolase I; Provisional; Region: PLN03044 698970005739 active site 698970005740 putative catalytic site residues [active] 698970005741 zinc binding site [ion binding]; other site 698970005742 GTP-CH-I/GFRP interaction surface; other site 698970005743 FtsH Extracellular; Region: FtsH_ext; pfam06480 698970005744 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 698970005745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698970005746 Walker A motif; other site 698970005747 ATP binding site [chemical binding]; other site 698970005748 Walker B motif; other site 698970005749 arginine finger; other site 698970005750 Peptidase family M41; Region: Peptidase_M41; pfam01434 698970005751 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698970005752 active site 698970005753 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 698970005754 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 698970005755 Ligand Binding Site [chemical binding]; other site 698970005756 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 698970005757 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 698970005758 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 698970005759 dimer interface [polypeptide binding]; other site 698970005760 substrate binding site [chemical binding]; other site 698970005761 metal binding sites [ion binding]; metal-binding site 698970005762 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698970005763 active site residue [active] 698970005764 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698970005765 MarR family; Region: MarR_2; pfam12802 698970005766 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698970005767 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 698970005768 acyl-activating enzyme (AAE) consensus motif; other site 698970005769 AMP binding site [chemical binding]; other site 698970005770 active site 698970005771 CoA binding site [chemical binding]; other site 698970005772 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698970005773 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 698970005774 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698970005775 putative trimer interface [polypeptide binding]; other site 698970005776 putative CoA binding site [chemical binding]; other site 698970005777 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698970005778 putative trimer interface [polypeptide binding]; other site 698970005779 putative CoA binding site [chemical binding]; other site 698970005780 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698970005781 metal ion-dependent adhesion site (MIDAS); other site 698970005782 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698970005783 active site 698970005784 catalytic site [active] 698970005785 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698970005786 Secretory lipase; Region: LIP; pfam03583 698970005787 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698970005788 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 698970005789 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698970005790 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698970005791 ring oligomerisation interface [polypeptide binding]; other site 698970005792 ATP/Mg binding site [chemical binding]; other site 698970005793 stacking interactions; other site 698970005794 hinge regions; other site 698970005795 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 698970005796 hypothetical protein; Reviewed; Region: PRK09588 698970005797 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 698970005798 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 698970005799 FMN binding site [chemical binding]; other site 698970005800 active site 698970005801 substrate binding site [chemical binding]; other site 698970005802 catalytic residue [active] 698970005803 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 698970005804 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698970005805 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698970005806 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970005807 Walker A/P-loop; other site 698970005808 ATP binding site [chemical binding]; other site 698970005809 Q-loop/lid; other site 698970005810 ABC transporter signature motif; other site 698970005811 Walker B; other site 698970005812 D-loop; other site 698970005813 H-loop/switch region; other site 698970005814 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698970005815 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698970005816 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698970005817 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698970005818 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698970005819 ATP binding site [chemical binding]; other site 698970005820 putative Mg++ binding site [ion binding]; other site 698970005821 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698970005822 nucleotide binding region [chemical binding]; other site 698970005823 ATP-binding site [chemical binding]; other site 698970005824 Abi-like protein; Region: Abi_2; cl01988 698970005825 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698970005826 Coenzyme A binding pocket [chemical binding]; other site 698970005827 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698970005828 non-specific DNA binding site [nucleotide binding]; other site 698970005829 salt bridge; other site 698970005830 sequence-specific DNA binding site [nucleotide binding]; other site 698970005831 HipA N-terminal domain; Region: Couple_hipA; pfam13657 698970005832 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 698970005833 HipA-like N-terminal domain; Region: HipA_N; pfam07805 698970005834 HipA-like C-terminal domain; Region: HipA_C; pfam07804 698970005835 potential frameshift: common BLAST hit: gi|227832479|ref|YP_002834186.1| Threonine/serine transporter 698970005836 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 698970005837 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 698970005838 HicB family; Region: HicB; pfam05534 698970005839 putative transposase OrfB; Reviewed; Region: PHA02517 698970005840 HTH-like domain; Region: HTH_21; pfam13276 698970005841 Integrase core domain; Region: rve; pfam00665 698970005842 Integrase core domain; Region: rve_2; pfam13333 698970005843 Winged helix-turn helix; Region: HTH_29; pfam13551 698970005844 Helix-turn-helix domain; Region: HTH_28; pfam13518 698970005845 chromosome segregation protein; Provisional; Region: PRK03918 698970005846 potential frameshift: common BLAST hit: gi|227832249|ref|YP_002833956.1| transposase 698970005847 MULE transposase domain; Region: MULE; pfam10551 698970005848 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698970005849 MULE transposase domain; Region: MULE; pfam10551 698970005850 hypothetical protein; Provisional; Region: PRK07907 698970005851 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 698970005852 active site 698970005853 metal binding site [ion binding]; metal-binding site 698970005854 dimer interface [polypeptide binding]; other site 698970005855 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698970005856 carboxylate-amine ligase; Provisional; Region: PRK13517 698970005857 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 698970005858 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698970005859 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698970005860 active site 698970005861 catalytic residues [active] 698970005862 metal binding site [ion binding]; metal-binding site 698970005863 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698970005864 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698970005865 Coenzyme A binding pocket [chemical binding]; other site 698970005866 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698970005867 putative catalytic site [active] 698970005868 putative metal binding site [ion binding]; other site 698970005869 putative phosphate binding site [ion binding]; other site 698970005870 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 698970005871 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 698970005872 putative active site [active] 698970005873 catalytic site [active] 698970005874 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 698970005875 putative active site [active] 698970005876 catalytic site [active] 698970005877 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698970005878 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698970005879 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970005880 Walker A/P-loop; other site 698970005881 ATP binding site [chemical binding]; other site 698970005882 Q-loop/lid; other site 698970005883 ABC transporter signature motif; other site 698970005884 Walker B; other site 698970005885 D-loop; other site 698970005886 H-loop/switch region; other site 698970005887 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 698970005888 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698970005889 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698970005890 substrate binding pocket [chemical binding]; other site 698970005891 membrane-bound complex binding site; other site 698970005892 hinge residues; other site 698970005893 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698970005894 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698970005895 active site 698970005896 ATP binding site [chemical binding]; other site 698970005897 substrate binding site [chemical binding]; other site 698970005898 activation loop (A-loop); other site 698970005899 propionate/acetate kinase; Provisional; Region: PRK12379 698970005900 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 698970005901 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 698970005902 ferredoxin-NADP+ reductase; Region: PLN02852 698970005903 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698970005904 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698970005905 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 698970005906 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698970005907 active site 698970005908 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698970005909 putative active site [active] 698970005910 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 698970005911 Cna protein B-type domain; Region: Cna_B; pfam05738 698970005912 Cna protein B-type domain; Region: Cna_B; pfam05738 698970005913 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 698970005914 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 698970005915 GDP-binding site [chemical binding]; other site 698970005916 ACT binding site; other site 698970005917 IMP binding site; other site 698970005918 conserved repeat domain; Region: B_ant_repeat; TIGR01451 698970005919 Cna protein B-type domain; Region: Cna_B; pfam05738 698970005920 Predicted membrane protein [Function unknown]; Region: COG4129 698970005921 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698970005922 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 698970005923 Predicted membrane protein [Function unknown]; Region: COG4129 698970005924 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698970005925 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 698970005926 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698970005927 Integrase core domain; Region: rve; pfam00665 698970005928 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 698970005929 catalytic nucleophile [active] 698970005930 Abi-like protein; Region: Abi_2; cl01988 698970005931 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698970005932 putative transporter; Provisional; Region: PRK09821 698970005933 GntP family permease; Region: GntP_permease; pfam02447 698970005934 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698970005935 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698970005936 NAD(P) binding site [chemical binding]; other site 698970005937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 698970005938 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698970005939 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698970005940 DNA-binding site [nucleotide binding]; DNA binding site 698970005941 FCD domain; Region: FCD; pfam07729 698970005942 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698970005943 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698970005944 FAD dependent oxidoreductase; Region: DAO; pfam01266 698970005945 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698970005946 Abi-like protein; Region: Abi_2; pfam07751 698970005947 potential frameshift: common BLAST hit: gi|172041139|ref|YP_001800853.1| transposase for insertion sequence 698970005948 Integrase core domain; Region: rve; pfam00665 698970005949 Cna protein B-type domain; Region: Cna_B; pfam05738 698970005950 Cna protein B-type domain; Region: Cna_B; pfam05738 698970005951 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 698970005952 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 698970005953 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 698970005954 Integrase core domain; Region: rve_3; cl15866 698970005955 potential frameshift: common BLAST hit: gi|38233368|ref|NP_939135.1| transposase 698970005956 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698970005957 Integrase core domain; Region: rve; pfam00665 698970005958 Helix-turn-helix domain; Region: HTH_38; pfam13936 698970005959 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 698970005960 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 698970005961 active site 698970005962 intersubunit interface [polypeptide binding]; other site 698970005963 zinc binding site [ion binding]; other site 698970005964 Na+ binding site [ion binding]; other site 698970005965 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 698970005966 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698970005967 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698970005968 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698970005969 active site 698970005970 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698970005971 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698970005972 active site residue [active] 698970005973 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698970005974 active site residue [active] 698970005975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698970005976 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 698970005977 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 698970005978 Clp amino terminal domain; Region: Clp_N; pfam02861 698970005979 Clp amino terminal domain; Region: Clp_N; pfam02861 698970005980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698970005981 Walker A motif; other site 698970005982 ATP binding site [chemical binding]; other site 698970005983 Walker B motif; other site 698970005984 arginine finger; other site 698970005985 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698970005986 Walker A motif; other site 698970005987 ATP binding site [chemical binding]; other site 698970005988 Walker B motif; other site 698970005989 arginine finger; other site 698970005990 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698970005991 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698970005992 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 698970005993 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698970005994 Walker A/P-loop; other site 698970005995 ATP binding site [chemical binding]; other site 698970005996 Q-loop/lid; other site 698970005997 ABC transporter signature motif; other site 698970005998 Walker B; other site 698970005999 D-loop; other site 698970006000 H-loop/switch region; other site 698970006001 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698970006002 EamA-like transporter family; Region: EamA; pfam00892 698970006003 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698970006004 EamA-like transporter family; Region: EamA; pfam00892 698970006005 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 698970006006 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 698970006007 FAD binding pocket [chemical binding]; other site 698970006008 FAD binding motif [chemical binding]; other site 698970006009 phosphate binding motif [ion binding]; other site 698970006010 beta-alpha-beta structure motif; other site 698970006011 NAD binding pocket [chemical binding]; other site 698970006012 Predicted amidohydrolase [General function prediction only]; Region: COG0388 698970006013 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 698970006014 putative active site [active] 698970006015 catalytic triad [active] 698970006016 putative dimer interface [polypeptide binding]; other site 698970006017 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 698970006018 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 698970006019 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 698970006020 NAD binding site [chemical binding]; other site 698970006021 substrate binding site [chemical binding]; other site 698970006022 catalytic Zn binding site [ion binding]; other site 698970006023 tetramer interface [polypeptide binding]; other site 698970006024 structural Zn binding site [ion binding]; other site 698970006025 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698970006026 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698970006027 NAD(P) binding site [chemical binding]; other site 698970006028 catalytic residues [active] 698970006029 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 698970006030 DNA binding residues [nucleotide binding] 698970006031 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698970006032 putative dimer interface [polypeptide binding]; other site 698970006033 chaperone protein DnaJ; Provisional; Region: PRK14279 698970006034 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698970006035 HSP70 interaction site [polypeptide binding]; other site 698970006036 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698970006037 Zn binding sites [ion binding]; other site 698970006038 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698970006039 dimer interface [polypeptide binding]; other site 698970006040 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 698970006041 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 698970006042 dimer interface [polypeptide binding]; other site 698970006043 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 698970006044 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 698970006045 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 698970006046 nucleotide binding site [chemical binding]; other site 698970006047 NEF interaction site [polypeptide binding]; other site 698970006048 SBD interface [polypeptide binding]; other site 698970006049 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698970006050 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698970006051 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698970006052 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698970006053 PAS domain; Region: PAS_9; pfam13426 698970006054 putative active site [active] 698970006055 heme pocket [chemical binding]; other site 698970006056 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698970006057 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698970006058 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698970006059 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698970006060 Walker A/P-loop; other site 698970006061 ATP binding site [chemical binding]; other site 698970006062 Q-loop/lid; other site 698970006063 ABC transporter signature motif; other site 698970006064 Walker B; other site 698970006065 D-loop; other site 698970006066 H-loop/switch region; other site 698970006067 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698970006068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698970006069 dimer interface [polypeptide binding]; other site 698970006070 conserved gate region; other site 698970006071 putative PBP binding loops; other site 698970006072 ABC-ATPase subunit interface; other site 698970006073 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698970006074 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 698970006075 Walker A/P-loop; other site 698970006076 ATP binding site [chemical binding]; other site 698970006077 Q-loop/lid; other site 698970006078 ABC transporter signature motif; other site 698970006079 Walker B; other site 698970006080 D-loop; other site 698970006081 H-loop/switch region; other site 698970006082 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698970006083 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698970006084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698970006085 dimer interface [polypeptide binding]; other site 698970006086 conserved gate region; other site 698970006087 putative PBP binding loops; other site 698970006088 ABC-ATPase subunit interface; other site 698970006089 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698970006090 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 698970006091 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698970006092 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698970006093 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 698970006094 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 698970006095 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 698970006096 dimerization interface [polypeptide binding]; other site 698970006097 ATP binding site [chemical binding]; other site 698970006098 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 698970006099 dimerization interface [polypeptide binding]; other site 698970006100 ATP binding site [chemical binding]; other site 698970006101 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 698970006102 putative active site [active] 698970006103 catalytic triad [active] 698970006104 nucleosidase; Provisional; Region: PRK05634 698970006105 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 698970006106 Permease; Region: Permease; cl00510 698970006107 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698970006108 4Fe-4S binding domain; Region: Fer4; cl02805 698970006109 Cysteine-rich domain; Region: CCG; pfam02754 698970006110 Cysteine-rich domain; Region: CCG; pfam02754 698970006111 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 698970006112 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698970006113 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 698970006114 putative NAD(P) binding site [chemical binding]; other site 698970006115 catalytic Zn binding site [ion binding]; other site 698970006116 aminotransferase AlaT; Validated; Region: PRK09265 698970006117 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698970006118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698970006119 homodimer interface [polypeptide binding]; other site 698970006120 catalytic residue [active] 698970006121 YibE/F-like protein; Region: YibE_F; pfam07907 698970006122 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 698970006123 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 698970006124 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698970006125 dimer interface [polypeptide binding]; other site 698970006126 putative anticodon binding site; other site 698970006127 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698970006128 motif 1; other site 698970006129 dimer interface [polypeptide binding]; other site 698970006130 active site 698970006131 motif 2; other site 698970006132 motif 3; other site 698970006133 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698970006134 Protein of unknown function (DUF998); Region: DUF998; pfam06197 698970006135 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 698970006136 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 698970006137 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 698970006138 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698970006139 trimer interface [polypeptide binding]; other site 698970006140 active site 698970006141 BRO family, N-terminal domain; Region: Bro-N; smart01040 698970006142 Abi-like protein; Region: Abi_2; cl01988 698970006143 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 698970006144 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698970006145 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698970006146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970006147 Walker A/P-loop; other site 698970006148 ATP binding site [chemical binding]; other site 698970006149 Q-loop/lid; other site 698970006150 ABC transporter signature motif; other site 698970006151 Walker B; other site 698970006152 D-loop; other site 698970006153 H-loop/switch region; other site 698970006154 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698970006155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970006156 Walker A/P-loop; other site 698970006157 ATP binding site [chemical binding]; other site 698970006158 Q-loop/lid; other site 698970006159 ABC transporter signature motif; other site 698970006160 Walker B; other site 698970006161 D-loop; other site 698970006162 H-loop/switch region; other site 698970006163 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 698970006164 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 698970006165 active site 698970006166 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 698970006167 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698970006168 Condensation domain; Region: Condensation; pfam00668 698970006169 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698970006170 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698970006171 Condensation domain; Region: Condensation; pfam00668 698970006172 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698970006173 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698970006174 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698970006175 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 698970006176 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698970006177 Condensation domain; Region: Condensation; pfam00668 698970006178 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698970006179 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 698970006180 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 698970006181 acyl-activating enzyme (AAE) consensus motif; other site 698970006182 AMP binding site [chemical binding]; other site 698970006183 Condensation domain; Region: Condensation; pfam00668 698970006184 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698970006185 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698970006186 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698970006187 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 698970006188 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698970006189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698970006190 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698970006191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698970006192 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698970006193 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 698970006194 Walker A/P-loop; other site 698970006195 ATP binding site [chemical binding]; other site 698970006196 Q-loop/lid; other site 698970006197 ABC transporter signature motif; other site 698970006198 Walker B; other site 698970006199 D-loop; other site 698970006200 H-loop/switch region; other site 698970006201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970006202 Walker A/P-loop; other site 698970006203 ATP binding site [chemical binding]; other site 698970006204 Q-loop/lid; other site 698970006205 ABC transporter signature motif; other site 698970006206 Walker B; other site 698970006207 D-loop; other site 698970006208 H-loop/switch region; other site 698970006209 metabolite-proton symporter; Region: 2A0106; TIGR00883 698970006210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970006211 putative substrate translocation pore; other site 698970006212 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698970006213 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698970006214 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 698970006215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970006216 putative substrate translocation pore; other site 698970006217 YwiC-like protein; Region: YwiC; pfam14256 698970006218 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698970006219 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698970006220 VanW like protein; Region: VanW; pfam04294 698970006221 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 698970006222 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 698970006223 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 698970006224 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 698970006225 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698970006226 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698970006227 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698970006228 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698970006229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698970006230 S-adenosylmethionine binding site [chemical binding]; other site 698970006231 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 698970006232 active site 698970006233 substrate-binding site [chemical binding]; other site 698970006234 metal-binding site [ion binding] 698970006235 GTP binding site [chemical binding]; other site 698970006236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698970006237 S-adenosylmethionine binding site [chemical binding]; other site 698970006238 LabA_like proteins; Region: LabA_like; cd06167 698970006239 putative metal binding site [ion binding]; other site 698970006240 MMPL family; Region: MMPL; pfam03176 698970006241 Protein of unknown function (DUF496); Region: DUF496; cl09955 698970006242 MMPL family; Region: MMPL; pfam03176 698970006243 Predicted integral membrane protein [Function unknown]; Region: COG0392 698970006244 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 698970006245 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 698970006246 TQXA domain; Region: TQXA_dom; TIGR03934 698970006247 potential frameshift: common BLAST hit: gi|337291728|ref|YP_004630749.1| protease CP40 698970006248 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 698970006249 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 698970006250 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698970006251 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698970006252 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698970006253 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698970006254 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 698970006255 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 698970006256 active site 698970006257 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 698970006258 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698970006259 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 698970006260 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 698970006261 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 698970006262 acyl-activating enzyme (AAE) consensus motif; other site 698970006263 active site 698970006264 Cutinase; Region: Cutinase; pfam01083 698970006265 Putative esterase; Region: Esterase; pfam00756 698970006266 S-formylglutathione hydrolase; Region: PLN02442 698970006267 LGFP repeat; Region: LGFP; pfam08310 698970006268 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698970006269 LGFP repeat; Region: LGFP; pfam08310 698970006270 LGFP repeat; Region: LGFP; pfam08310 698970006271 Predicted esterase [General function prediction only]; Region: COG0627 698970006272 S-formylglutathione hydrolase; Region: PLN02442 698970006273 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 698970006274 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 698970006275 UbiA prenyltransferase family; Region: UbiA; pfam01040 698970006276 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698970006277 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698970006278 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698970006279 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698970006280 active site 698970006281 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698970006282 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698970006283 NAD(P) binding site [chemical binding]; other site 698970006284 catalytic residues [active] 698970006285 BCCT family transporter; Region: BCCT; cl00569 698970006286 choline dehydrogenase; Validated; Region: PRK02106 698970006287 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698970006288 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 698970006289 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698970006290 UDP-galactopyranose mutase; Region: GLF; pfam03275 698970006291 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 698970006292 Firmicute plasmid replication protein (RepL); Region: RepL; pfam05732 698970006293 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 698970006294 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698970006295 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970006296 ABC transporter signature motif; other site 698970006297 Walker B; other site 698970006298 D-loop; other site 698970006299 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698970006300 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698970006301 amidase catalytic site [active] 698970006302 Zn binding residues [ion binding]; other site 698970006303 substrate binding site [chemical binding]; other site 698970006304 LGFP repeat; Region: LGFP; pfam08310 698970006305 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 698970006306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698970006307 Integrase core domain; Region: rve; pfam00665 698970006308 Protein P3 of Potyviral polyprotein; Region: Potyvirid-P3; pfam13608 698970006309 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698970006310 active site 698970006311 catalytic site [active] 698970006312 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698970006313 active site 698970006314 catalytic site [active] 698970006315 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698970006316 Cna protein B-type domain; Region: Cna_B; pfam05738 698970006317 Cna protein B-type domain; Region: Cna_B; pfam05738 698970006318 Cna protein B-type domain; Region: Cna_B; pfam05738 698970006319 Cna protein B-type domain; Region: Cna_B; pfam05738 698970006320 Cna protein B-type domain; Region: Cna_B; pfam05738 698970006321 Cna protein B-type domain; Region: Cna_B; pfam05738 698970006322 HTH-like domain; Region: HTH_21; pfam13276 698970006323 Integrase core domain; Region: rve; pfam00665 698970006324 glycerol kinase; Provisional; Region: glpK; PRK00047 698970006325 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 698970006326 N- and C-terminal domain interface [polypeptide binding]; other site 698970006327 active site 698970006328 MgATP binding site [chemical binding]; other site 698970006329 catalytic site [active] 698970006330 metal binding site [ion binding]; metal-binding site 698970006331 putative homotetramer interface [polypeptide binding]; other site 698970006332 glycerol binding site [chemical binding]; other site 698970006333 homodimer interface [polypeptide binding]; other site 698970006334 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 698970006335 amphipathic channel; other site 698970006336 Asn-Pro-Ala signature motifs; other site 698970006337 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 698970006338 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698970006339 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698970006340 putative acyl-acceptor binding pocket; other site 698970006341 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698970006342 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698970006343 active site 698970006344 motif I; other site 698970006345 motif II; other site 698970006346 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698970006347 seryl-tRNA synthetase; Provisional; Region: PRK05431 698970006348 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 698970006349 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 698970006350 dimer interface [polypeptide binding]; other site 698970006351 active site 698970006352 motif 1; other site 698970006353 motif 2; other site 698970006354 motif 3; other site 698970006355 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698970006356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698970006357 DNA-binding site [nucleotide binding]; DNA binding site 698970006358 UTRA domain; Region: UTRA; pfam07702 698970006359 Septum formation; Region: Septum_form; pfam13845 698970006360 Septum formation; Region: Septum_form; pfam13845 698970006361 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 698970006362 AAA domain; Region: AAA_14; pfam13173 698970006363 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 698970006364 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698970006365 catalytic core [active] 698970006366 prephenate dehydratase; Provisional; Region: PRK11898 698970006367 Prephenate dehydratase; Region: PDT; pfam00800 698970006368 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 698970006369 putative L-Phe binding site [chemical binding]; other site 698970006370 Amidase; Region: Amidase; cl11426 698970006371 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698970006372 CAAX protease self-immunity; Region: Abi; pfam02517 698970006373 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 698970006374 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698970006375 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698970006376 amino acid carrier protein; Region: agcS; TIGR00835 698970006377 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698970006378 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 698970006379 catalytic triad [active] 698970006380 catalytic triad [active] 698970006381 oxyanion hole [active] 698970006382 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698970006383 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 698970006384 putative active site [active] 698970006385 catalytic site [active] 698970006386 putative metal binding site [ion binding]; other site 698970006387 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 698970006388 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 698970006389 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698970006390 NAD binding site [chemical binding]; other site 698970006391 dimer interface [polypeptide binding]; other site 698970006392 substrate binding site [chemical binding]; other site 698970006393 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 698970006394 nudix motif; other site 698970006395 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 698970006396 quinolinate synthetase; Provisional; Region: PRK09375 698970006397 L-aspartate oxidase; Provisional; Region: PRK06175 698970006398 FAD binding domain; Region: FAD_binding_2; pfam00890 698970006399 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 698970006400 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 698970006401 dimerization interface [polypeptide binding]; other site 698970006402 active site 698970006403 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 698970006404 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 698970006405 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 698970006406 Predicted flavoprotein [General function prediction only]; Region: COG0431 698970006407 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698970006408 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 698970006409 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 698970006410 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698970006411 Lsr2; Region: Lsr2; pfam11774 698970006412 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698970006413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698970006414 active site 698970006415 phosphorylation site [posttranslational modification] 698970006416 intermolecular recognition site; other site 698970006417 dimerization interface [polypeptide binding]; other site 698970006418 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698970006419 DNA binding residues [nucleotide binding] 698970006420 dimerization interface [polypeptide binding]; other site 698970006421 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698970006422 Histidine kinase; Region: HisKA_3; pfam07730 698970006423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698970006424 ATP binding site [chemical binding]; other site 698970006425 Mg2+ binding site [ion binding]; other site 698970006426 G-X-G motif; other site 698970006427 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 698970006428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970006429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970006430 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 698970006431 active site 698970006432 catalytic site [active] 698970006433 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 698970006434 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 698970006435 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698970006436 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698970006437 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698970006438 Ligand Binding Site [chemical binding]; other site 698970006439 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698970006440 Ligand Binding Site [chemical binding]; other site 698970006441 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 698970006442 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698970006443 probable active site [active] 698970006444 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698970006445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970006446 Walker A/P-loop; other site 698970006447 ATP binding site [chemical binding]; other site 698970006448 Q-loop/lid; other site 698970006449 ABC transporter signature motif; other site 698970006450 Walker B; other site 698970006451 D-loop; other site 698970006452 H-loop/switch region; other site 698970006453 Predicted transcriptional regulators [Transcription]; Region: COG1725 698970006454 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698970006455 DNA-binding site [nucleotide binding]; DNA binding site 698970006456 LabA_like proteins; Region: LabA_like; cd06167 698970006457 putative metal binding site [ion binding]; other site 698970006458 Uncharacterized conserved protein [Function unknown]; Region: COG1432 698970006459 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698970006460 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698970006461 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698970006462 catalytic residues [active] 698970006463 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698970006464 metal-binding site [ion binding] 698970006465 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698970006466 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698970006467 metal-binding site [ion binding] 698970006468 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698970006469 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698970006470 benzoate transport; Region: 2A0115; TIGR00895 698970006471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970006472 putative substrate translocation pore; other site 698970006473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698970006474 replicative DNA helicase; Provisional; Region: PRK05636 698970006475 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 698970006476 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 698970006477 Walker A motif; other site 698970006478 ATP binding site [chemical binding]; other site 698970006479 Walker B motif; other site 698970006480 DNA binding loops [nucleotide binding] 698970006481 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 698970006482 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 698970006483 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 698970006484 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698970006485 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698970006486 dimer interface [polypeptide binding]; other site 698970006487 ssDNA binding site [nucleotide binding]; other site 698970006488 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698970006489 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 698970006490 Predicted integral membrane protein [Function unknown]; Region: COG5650 698970006491 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698970006492 Transglycosylase; Region: Transgly; pfam00912 698970006493 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698970006494 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698970006495 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698970006496 Ligand Binding Site [chemical binding]; other site 698970006497 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698970006498 Ligand Binding Site [chemical binding]; other site 698970006499 classical (c) SDRs; Region: SDR_c; cd05233 698970006500 short chain dehydrogenase; Provisional; Region: PRK08219 698970006501 NAD(P) binding site [chemical binding]; other site 698970006502 active site 698970006503 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698970006504 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698970006505 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 698970006506 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 698970006507 active site residue [active] 698970006508 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 698970006509 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698970006510 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 698970006511 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 698970006512 dimerization interface [polypeptide binding]; other site 698970006513 DPS ferroxidase diiron center [ion binding]; other site 698970006514 ion pore; other site 698970006515 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698970006516 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 698970006517 putative DNA binding site [nucleotide binding]; other site 698970006518 catalytic residue [active] 698970006519 putative H2TH interface [polypeptide binding]; other site 698970006520 putative catalytic residues [active] 698970006521 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698970006522 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698970006523 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 698970006524 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 698970006525 putative substrate binding site [chemical binding]; other site 698970006526 putative ATP binding site [chemical binding]; other site 698970006527 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 698970006528 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 698970006529 active site 698970006530 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698970006531 AAA domain; Region: AAA_31; pfam13614 698970006532 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698970006533 P-loop; other site 698970006534 Magnesium ion binding site [ion binding]; other site 698970006535 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698970006536 Magnesium ion binding site [ion binding]; other site 698970006537 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698970006538 Divergent AAA domain; Region: AAA_4; pfam04326 698970006539 Divergent AAA domain; Region: AAA_4; pfam04326 698970006540 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698970006541 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698970006542 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 698970006543 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698970006544 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698970006545 ATP binding site [chemical binding]; other site 698970006546 putative Mg++ binding site [ion binding]; other site 698970006547 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 698970006548 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698970006549 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 698970006550 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698970006551 HsdM N-terminal domain; Region: HsdM_N; pfam12161 698970006552 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 698970006553 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698970006554 Fic family protein [Function unknown]; Region: COG3177 698970006555 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698970006556 Fic/DOC family; Region: Fic; pfam02661 698970006557 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 698970006558 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 698970006559 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 698970006560 E-class dimer interface [polypeptide binding]; other site 698970006561 P-class dimer interface [polypeptide binding]; other site 698970006562 active site 698970006563 Cu2+ binding site [ion binding]; other site 698970006564 Zn2+ binding site [ion binding]; other site 698970006565 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 698970006566 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698970006567 active site 698970006568 HIGH motif; other site 698970006569 nucleotide binding site [chemical binding]; other site 698970006570 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698970006571 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698970006572 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698970006573 active site 698970006574 KMSKS motif; other site 698970006575 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 698970006576 tRNA binding surface [nucleotide binding]; other site 698970006577 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698970006578 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698970006579 Walker A/P-loop; other site 698970006580 ATP binding site [chemical binding]; other site 698970006581 Q-loop/lid; other site 698970006582 ABC transporter signature motif; other site 698970006583 Walker B; other site 698970006584 D-loop; other site 698970006585 H-loop/switch region; other site 698970006586 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698970006587 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698970006588 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698970006589 Histidine kinase; Region: HisKA_3; pfam07730 698970006590 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698970006591 ATP binding site [chemical binding]; other site 698970006592 G-X-G motif; other site 698970006593 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698970006594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698970006595 active site 698970006596 phosphorylation site [posttranslational modification] 698970006597 intermolecular recognition site; other site 698970006598 dimerization interface [polypeptide binding]; other site 698970006599 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698970006600 DNA binding residues [nucleotide binding] 698970006601 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698970006602 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698970006603 Predicted membrane protein [Function unknown]; Region: COG1511 698970006604 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698970006605 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698970006606 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698970006607 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698970006608 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698970006609 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698970006610 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 698970006611 NAD(P) binding site [chemical binding]; other site 698970006612 catalytic residues [active] 698970006613 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698970006614 active site 698970006615 phosphorylation site [posttranslational modification] 698970006616 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 698970006617 active site 698970006618 P-loop; other site 698970006619 phosphorylation site [posttranslational modification] 698970006620 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 698970006621 Putative esterase; Region: Esterase; pfam00756 698970006622 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 698970006623 active site 698970006624 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698970006625 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970006626 ABC transporter signature motif; other site 698970006627 Walker B; other site 698970006628 D-loop; other site 698970006629 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698970006630 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698970006631 Walker A/P-loop; other site 698970006632 ATP binding site [chemical binding]; other site 698970006633 Q-loop/lid; other site 698970006634 ABC transporter signature motif; other site 698970006635 Walker B; other site 698970006636 D-loop; other site 698970006637 H-loop/switch region; other site 698970006638 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 698970006639 active site 698970006640 catalytic residues [active] 698970006641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 698970006642 hypothetical protein; Provisional; Region: PRK13663 698970006643 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698970006644 putative active site [active] 698970006645 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698970006646 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698970006647 SdpI/YhfL protein family; Region: SdpI; pfam13630 698970006648 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698970006649 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698970006650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698970006651 catalytic residue [active] 698970006652 anthranilate synthase component I; Provisional; Region: PRK13564 698970006653 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 698970006654 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 698970006655 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698970006656 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698970006657 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698970006658 glutamine binding [chemical binding]; other site 698970006659 catalytic triad [active] 698970006660 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 698970006661 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698970006662 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698970006663 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 698970006664 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698970006665 active site 698970006666 ribulose/triose binding site [chemical binding]; other site 698970006667 phosphate binding site [ion binding]; other site 698970006668 substrate (anthranilate) binding pocket [chemical binding]; other site 698970006669 product (indole) binding pocket [chemical binding]; other site 698970006670 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 698970006671 active site 698970006672 Protein of unknown function (DUF454); Region: DUF454; cl01063 698970006673 pantoate--beta-alanine ligase; Region: panC; TIGR00018 698970006674 Pantoate-beta-alanine ligase; Region: PanC; cd00560 698970006675 active site 698970006676 ATP-binding site [chemical binding]; other site 698970006677 pantoate-binding site; other site 698970006678 HXXH motif; other site 698970006679 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 698970006680 oligomerization interface [polypeptide binding]; other site 698970006681 active site 698970006682 metal binding site [ion binding]; metal-binding site 698970006683 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698970006684 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698970006685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698970006686 catalytic residue [active] 698970006687 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 698970006688 substrate binding site [chemical binding]; other site 698970006689 active site 698970006690 catalytic residues [active] 698970006691 heterodimer interface [polypeptide binding]; other site 698970006692 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698970006693 iron-sulfur cluster [ion binding]; other site 698970006694 [2Fe-2S] cluster binding site [ion binding]; other site 698970006695 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 698970006696 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698970006697 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 698970006698 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 698970006699 hypothetical protein; Validated; Region: PRK00228 698970006700 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 698970006701 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 698970006702 active site 698970006703 NTP binding site [chemical binding]; other site 698970006704 metal binding triad [ion binding]; metal-binding site 698970006705 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 698970006706 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698970006707 Zn2+ binding site [ion binding]; other site 698970006708 Mg2+ binding site [ion binding]; other site 698970006709 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 698970006710 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698970006711 active site 698970006712 Ap6A binding site [chemical binding]; other site 698970006713 nudix motif; other site 698970006714 metal binding site [ion binding]; metal-binding site 698970006715 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 698970006716 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 698970006717 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 698970006718 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698970006719 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698970006720 DNA binding residues [nucleotide binding] 698970006721 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 698970006722 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698970006723 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698970006724 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698970006725 catalytic residues [active] 698970006726 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698970006727 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698970006728 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 698970006729 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 698970006730 active site 698970006731 metal binding site [ion binding]; metal-binding site 698970006732 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 698970006733 ParB-like nuclease domain; Region: ParBc; pfam02195 698970006734 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698970006735 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698970006736 P-loop; other site 698970006737 Magnesium ion binding site [ion binding]; other site 698970006738 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698970006739 Magnesium ion binding site [ion binding]; other site 698970006740 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 698970006741 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 698970006742 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 698970006743 Haemolytic domain; Region: Haemolytic; pfam01809 698970006744 ribonuclease P; Reviewed; Region: rnpA; PRK03459 698970006745 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399