-- dump date 20140619_051115 -- class Genbank::misc_feature -- table misc_feature_note -- id note 698972000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 698972000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698972000003 Walker A motif; other site 698972000004 ATP binding site [chemical binding]; other site 698972000005 Walker B motif; other site 698972000006 arginine finger; other site 698972000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 698972000008 DnaA box-binding interface [nucleotide binding]; other site 698972000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 698972000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 698972000011 putative DNA binding surface [nucleotide binding]; other site 698972000012 dimer interface [polypeptide binding]; other site 698972000013 beta-clamp/clamp loader binding surface; other site 698972000014 beta-clamp/translesion DNA polymerase binding surface; other site 698972000015 recombination protein F; Reviewed; Region: recF; PRK00064 698972000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 698972000017 Walker A/P-loop; other site 698972000018 ATP binding site [chemical binding]; other site 698972000019 Q-loop/lid; other site 698972000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972000021 ABC transporter signature motif; other site 698972000022 Walker B; other site 698972000023 D-loop; other site 698972000024 H-loop/switch region; other site 698972000025 hypothetical protein; Provisional; Region: PRK00111 698972000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 698972000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698972000028 ATP binding site [chemical binding]; other site 698972000029 Mg2+ binding site [ion binding]; other site 698972000030 G-X-G motif; other site 698972000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698972000032 anchoring element; other site 698972000033 dimer interface [polypeptide binding]; other site 698972000034 ATP binding site [chemical binding]; other site 698972000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 698972000036 active site 698972000037 putative metal-binding site [ion binding]; other site 698972000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698972000039 DNA gyrase subunit A; Validated; Region: PRK05560 698972000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 698972000041 CAP-like domain; other site 698972000042 active site 698972000043 primary dimer interface [polypeptide binding]; other site 698972000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698972000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698972000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698972000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698972000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698972000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698972000050 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 698972000051 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698972000052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698972000053 DNA-binding site [nucleotide binding]; DNA binding site 698972000054 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698972000055 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698972000056 L-lactate permease; Region: Lactate_perm; cl00701 698972000057 Cadherin repeat-like domain; Region: CA_like; cl15786 698972000058 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698972000059 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698972000060 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 698972000061 Walker A/P-loop; other site 698972000062 ATP binding site [chemical binding]; other site 698972000063 Q-loop/lid; other site 698972000064 ABC transporter signature motif; other site 698972000065 Walker B; other site 698972000066 D-loop; other site 698972000067 H-loop/switch region; other site 698972000068 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698972000069 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698972000070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972000071 Walker A/P-loop; other site 698972000072 ATP binding site [chemical binding]; other site 698972000073 Q-loop/lid; other site 698972000074 ABC transporter signature motif; other site 698972000075 Walker B; other site 698972000076 D-loop; other site 698972000077 H-loop/switch region; other site 698972000078 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698972000079 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 698972000080 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698972000081 putative ligand binding site [chemical binding]; other site 698972000082 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698972000083 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698972000084 TM-ABC transporter signature motif; other site 698972000085 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698972000086 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698972000087 Walker A/P-loop; other site 698972000088 ATP binding site [chemical binding]; other site 698972000089 Q-loop/lid; other site 698972000090 ABC transporter signature motif; other site 698972000091 Walker B; other site 698972000092 D-loop; other site 698972000093 H-loop/switch region; other site 698972000094 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698972000095 active site 698972000096 Integrase core domain; Region: rve_2; pfam13333 698972000097 Rhomboid family; Region: Rhomboid; pfam01694 698972000098 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 698972000099 ThiC-associated domain; Region: ThiC-associated; pfam13667 698972000100 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 698972000101 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698972000102 thiamine phosphate binding site [chemical binding]; other site 698972000103 active site 698972000104 pyrophosphate binding site [ion binding]; other site 698972000105 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698972000106 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 698972000107 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 698972000108 thiS-thiF/thiG interaction site; other site 698972000109 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 698972000110 ThiS interaction site; other site 698972000111 putative active site [active] 698972000112 tetramer interface [polypeptide binding]; other site 698972000113 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 698972000114 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698972000115 ATP binding site [chemical binding]; other site 698972000116 substrate interface [chemical binding]; other site 698972000117 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698972000118 active site residue [active] 698972000119 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 698972000120 dimer interface [polypeptide binding]; other site 698972000121 substrate binding site [chemical binding]; other site 698972000122 ATP binding site [chemical binding]; other site 698972000123 helicase Cas3; Provisional; Region: PRK09694 698972000124 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 698972000125 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698972000126 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 698972000127 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 698972000128 CT1975-like protein; Region: Cas_CT1975; pfam09344 698972000129 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 698972000130 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 698972000131 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 698972000132 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 698972000133 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 698972000134 putative septation inhibitor protein; Reviewed; Region: PRK00159 698972000135 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698972000136 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698972000137 active site 698972000138 ATP binding site [chemical binding]; other site 698972000139 substrate binding site [chemical binding]; other site 698972000140 activation loop (A-loop); other site 698972000141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698972000142 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698972000143 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698972000144 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698972000145 PASTA domain; Region: PASTA; pfam03793 698972000146 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698972000147 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698972000148 active site 698972000149 ATP binding site [chemical binding]; other site 698972000150 substrate binding site [chemical binding]; other site 698972000151 activation loop (A-loop); other site 698972000152 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698972000153 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698972000154 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698972000155 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 698972000156 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 698972000157 Protein phosphatase 2C; Region: PP2C; pfam00481 698972000158 active site 698972000159 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698972000160 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698972000161 phosphopeptide binding site; other site 698972000162 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 698972000163 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698972000164 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698972000165 phosphopeptide binding site; other site 698972000166 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698972000167 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698972000168 non-specific DNA binding site [nucleotide binding]; other site 698972000169 salt bridge; other site 698972000170 sequence-specific DNA binding site [nucleotide binding]; other site 698972000171 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 698972000172 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 698972000173 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 698972000174 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698972000175 Walker A/P-loop; other site 698972000176 ATP binding site [chemical binding]; other site 698972000177 Q-loop/lid; other site 698972000178 ABC transporter signature motif; other site 698972000179 Walker B; other site 698972000180 D-loop; other site 698972000181 H-loop/switch region; other site 698972000182 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698972000183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698972000184 active site 698972000185 phosphorylation site [posttranslational modification] 698972000186 intermolecular recognition site; other site 698972000187 dimerization interface [polypeptide binding]; other site 698972000188 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698972000189 DNA binding residues [nucleotide binding] 698972000190 dimerization interface [polypeptide binding]; other site 698972000191 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698972000192 Histidine kinase; Region: HisKA_3; pfam07730 698972000193 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698972000194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698972000195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698972000196 dimer interface [polypeptide binding]; other site 698972000197 conserved gate region; other site 698972000198 putative PBP binding loops; other site 698972000199 ABC-ATPase subunit interface; other site 698972000200 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 698972000201 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 698972000202 Walker A/P-loop; other site 698972000203 ATP binding site [chemical binding]; other site 698972000204 Q-loop/lid; other site 698972000205 ABC transporter signature motif; other site 698972000206 Walker B; other site 698972000207 D-loop; other site 698972000208 H-loop/switch region; other site 698972000209 Anti-sigma-K factor rskA; Region: RskA; pfam10099 698972000210 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 698972000211 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698972000212 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698972000213 DNA binding residues [nucleotide binding] 698972000214 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698972000215 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698972000216 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 698972000217 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698972000218 catalytic residues [active] 698972000219 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 698972000220 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 698972000221 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 698972000222 putative metal binding site [ion binding]; other site 698972000223 biotin synthase; Validated; Region: PRK06256 698972000224 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698972000225 FeS/SAM binding site; other site 698972000226 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698972000227 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 698972000228 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 698972000229 putative ligand binding residues [chemical binding]; other site 698972000230 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698972000231 ABC-ATPase subunit interface; other site 698972000232 dimer interface [polypeptide binding]; other site 698972000233 putative PBP binding regions; other site 698972000234 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698972000235 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698972000236 Walker A/P-loop; other site 698972000237 ATP binding site [chemical binding]; other site 698972000238 Q-loop/lid; other site 698972000239 ABC transporter signature motif; other site 698972000240 Walker B; other site 698972000241 D-loop; other site 698972000242 H-loop/switch region; other site 698972000243 Uncharacterized conserved protein [Function unknown]; Region: COG5646 698972000244 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 698972000245 DNA photolyase; Region: DNA_photolyase; pfam00875 698972000246 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 698972000247 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 698972000248 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 698972000249 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 698972000250 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 698972000251 Lipase (class 2); Region: Lipase_2; pfam01674 698972000252 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 698972000253 dimer interface [polypeptide binding]; other site 698972000254 FMN binding site [chemical binding]; other site 698972000255 Divergent AAA domain; Region: AAA_4; pfam04326 698972000256 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698972000257 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698972000258 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 698972000259 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 698972000260 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 698972000261 trimer interface [polypeptide binding]; other site 698972000262 putative metal binding site [ion binding]; other site 698972000263 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698972000264 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 698972000265 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 698972000266 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 698972000267 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698972000268 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698972000269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 698972000270 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698972000271 MarR family; Region: MarR; pfam01047 698972000272 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698972000273 hypothetical protein; Provisional; Region: PRK10621 698972000274 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698972000275 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 698972000276 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698972000277 ATP binding site [chemical binding]; other site 698972000278 putative Mg++ binding site [ion binding]; other site 698972000279 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698972000280 nucleotide binding region [chemical binding]; other site 698972000281 Helicase associated domain (HA2); Region: HA2; pfam04408 698972000282 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 698972000283 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 698972000284 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698972000285 putative CoA binding site [chemical binding]; other site 698972000286 putative trimer interface [polypeptide binding]; other site 698972000287 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698972000288 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 698972000289 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698972000290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698972000291 NAD(P) binding site [chemical binding]; other site 698972000292 active site 698972000293 Helix-turn-helix domain; Region: HTH_28; pfam13518 698972000294 HTH-like domain; Region: HTH_21; pfam13276 698972000295 Integrase core domain; Region: rve; pfam00665 698972000296 Integrase core domain; Region: rve_2; pfam13333 698972000297 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 698972000298 LGFP repeat; Region: LGFP; pfam08310 698972000299 LGFP repeat; Region: LGFP; pfam08310 698972000300 LGFP repeat; Region: LGFP; pfam08310 698972000301 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 698972000302 Short repeats of unknown function; Region: ALF; pfam03752 698972000303 potential frameshift: common BLAST hit: gi|336325819|ref|YP_004605785.1| transposase for insertion sequence element 698972000304 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698972000305 Integrase core domain; Region: rve; pfam00665 698972000306 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 698972000307 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 698972000308 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698972000309 RNA binding surface [nucleotide binding]; other site 698972000310 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698972000311 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698972000312 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698972000313 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 698972000314 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 698972000315 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 698972000316 active site 698972000317 Zn binding site [ion binding]; other site 698972000318 Protease prsW family; Region: PrsW-protease; pfam13367 698972000319 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698972000320 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 698972000321 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 698972000322 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 698972000323 short chain dehydrogenase; Provisional; Region: PRK07904 698972000324 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698972000325 NAD(P) binding site [chemical binding]; other site 698972000326 active site 698972000327 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698972000328 FAD binding domain; Region: FAD_binding_4; pfam01565 698972000329 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 698972000330 Predicted membrane protein [Function unknown]; Region: COG2246 698972000331 GtrA-like protein; Region: GtrA; pfam04138 698972000332 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698972000333 putative active site [active] 698972000334 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698972000335 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698972000336 active site 698972000337 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698972000338 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698972000339 intersubunit interface [polypeptide binding]; other site 698972000340 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698972000341 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698972000342 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698972000343 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698972000344 ABC-ATPase subunit interface; other site 698972000345 dimer interface [polypeptide binding]; other site 698972000346 putative PBP binding regions; other site 698972000347 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698972000348 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698972000349 ABC-ATPase subunit interface; other site 698972000350 dimer interface [polypeptide binding]; other site 698972000351 putative PBP binding regions; other site 698972000352 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698972000353 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698972000354 intersubunit interface [polypeptide binding]; other site 698972000355 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 698972000356 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 698972000357 Walker A/P-loop; other site 698972000358 ATP binding site [chemical binding]; other site 698972000359 Q-loop/lid; other site 698972000360 ABC transporter signature motif; other site 698972000361 Walker B; other site 698972000362 D-loop; other site 698972000363 H-loop/switch region; other site 698972000364 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 698972000365 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698972000366 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698972000367 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698972000368 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698972000369 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 698972000370 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 698972000371 NAD(P) binding site [chemical binding]; other site 698972000372 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 698972000373 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698972000374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698972000375 homodimer interface [polypeptide binding]; other site 698972000376 catalytic residue [active] 698972000377 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 698972000378 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 698972000379 transmembrane helices; other site 698972000380 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698972000381 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 698972000382 NodB motif; other site 698972000383 active site 698972000384 catalytic site [active] 698972000385 metal binding site [ion binding]; metal-binding site 698972000386 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698972000387 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698972000388 DNA-binding site [nucleotide binding]; DNA binding site 698972000389 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698972000390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698972000391 homodimer interface [polypeptide binding]; other site 698972000392 catalytic residue [active] 698972000393 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 698972000394 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 698972000395 active site 698972000396 multimer interface [polypeptide binding]; other site 698972000397 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 698972000398 predicted active site [active] 698972000399 catalytic triad [active] 698972000400 potential frameshift: common BLAST hit: gi|68535288|ref|YP_249993.1| transposase IS3510a 698972000401 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698972000402 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698972000403 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698972000404 active site 698972000405 catalytic site [active] 698972000406 Cna protein B-type domain; Region: Cna_B; pfam05738 698972000407 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698972000408 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698972000409 active site 698972000410 catalytic site [active] 698972000411 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698972000412 metal ion-dependent adhesion site (MIDAS); other site 698972000413 prephenate dehydrogenase; Validated; Region: PRK06545 698972000414 prephenate dehydrogenase; Validated; Region: PRK08507 698972000415 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 698972000416 nucleoside/Zn binding site; other site 698972000417 dimer interface [polypeptide binding]; other site 698972000418 catalytic motif [active] 698972000419 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 698972000420 DNA binding residues [nucleotide binding] 698972000421 PIN domain; Region: PIN_3; pfam13470 698972000422 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 698972000423 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 698972000424 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 698972000425 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 698972000426 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 698972000427 active site 698972000428 HIGH motif; other site 698972000429 nucleotide binding site [chemical binding]; other site 698972000430 active site 698972000431 KMSKS motif; other site 698972000432 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 698972000433 fructuronate transporter; Provisional; Region: PRK10034; cl15264 698972000434 Shikimate kinase; Region: SKI; pfam01202 698972000435 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 698972000436 L-idonate 5-dehydrogenase; Region: PLN02702 698972000437 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 698972000438 putative NAD(P) binding site [chemical binding]; other site 698972000439 catalytic Zn binding site [ion binding]; other site 698972000440 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 698972000441 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 698972000442 NADP binding site [chemical binding]; other site 698972000443 homodimer interface [polypeptide binding]; other site 698972000444 active site 698972000445 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 698972000446 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698972000447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698972000448 homodimer interface [polypeptide binding]; other site 698972000449 catalytic residue [active] 698972000450 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 698972000451 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 698972000452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698972000453 Walker A motif; other site 698972000454 ATP binding site [chemical binding]; other site 698972000455 Walker B motif; other site 698972000456 arginine finger; other site 698972000457 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 698972000458 hypothetical protein; Validated; Region: PRK00153 698972000459 recombination protein RecR; Reviewed; Region: recR; PRK00076 698972000460 RecR protein; Region: RecR; pfam02132 698972000461 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 698972000462 putative active site [active] 698972000463 putative metal-binding site [ion binding]; other site 698972000464 tetramer interface [polypeptide binding]; other site 698972000465 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698972000466 catalytic triad [active] 698972000467 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 698972000468 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698972000469 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 698972000470 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 698972000471 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698972000472 active site 698972000473 catalytic site [active] 698972000474 substrate binding site [chemical binding]; other site 698972000475 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 698972000476 dimer interface [polypeptide binding]; other site 698972000477 FMN binding site [chemical binding]; other site 698972000478 NADPH bind site [chemical binding]; other site 698972000479 2-isopropylmalate synthase; Validated; Region: PRK03739 698972000480 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 698972000481 active site 698972000482 catalytic residues [active] 698972000483 metal binding site [ion binding]; metal-binding site 698972000484 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 698972000485 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698972000486 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698972000487 DNA binding residues [nucleotide binding] 698972000488 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698972000489 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698972000490 active site 698972000491 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 698972000492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972000493 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698972000494 putative substrate translocation pore; other site 698972000495 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 698972000496 intersubunit interface [polypeptide binding]; other site 698972000497 active site 698972000498 catalytic residue [active] 698972000499 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 698972000500 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 698972000501 active site 698972000502 substrate binding site [chemical binding]; other site 698972000503 metal binding site [ion binding]; metal-binding site 698972000504 aspartate kinase; Reviewed; Region: PRK06635 698972000505 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 698972000506 putative nucleotide binding site [chemical binding]; other site 698972000507 putative catalytic residues [active] 698972000508 putative Mg ion binding site [ion binding]; other site 698972000509 putative aspartate binding site [chemical binding]; other site 698972000510 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 698972000511 putative allosteric regulatory site; other site 698972000512 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 698972000513 putative allosteric regulatory residue; other site 698972000514 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 698972000515 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698972000516 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698972000517 Helix-turn-helix domain; Region: HTH_28; pfam13518 698972000518 Integrase core domain; Region: rve; pfam00665 698972000519 Cna protein B-type domain; Region: Cna_B; pfam05738 698972000520 Cna protein B-type domain; Region: Cna_B; pfam05738 698972000521 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 698972000522 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698972000523 active site 698972000524 catalytic site [active] 698972000525 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698972000526 active site 698972000527 catalytic site [active] 698972000528 RNA polymerase sigma factor; Provisional; Region: PRK12535 698972000529 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698972000530 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698972000531 DNA binding residues [nucleotide binding] 698972000532 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 698972000533 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 698972000534 heme binding pocket [chemical binding]; other site 698972000535 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698972000536 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 698972000537 Walker A/P-loop; other site 698972000538 ATP binding site [chemical binding]; other site 698972000539 Q-loop/lid; other site 698972000540 ABC transporter signature motif; other site 698972000541 Walker B; other site 698972000542 D-loop; other site 698972000543 H-loop/switch region; other site 698972000544 TOBE domain; Region: TOBE_2; pfam08402 698972000545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698972000546 dimer interface [polypeptide binding]; other site 698972000547 conserved gate region; other site 698972000548 ABC-ATPase subunit interface; other site 698972000549 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698972000550 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 698972000551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972000552 putative substrate translocation pore; other site 698972000553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972000554 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698972000555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698972000556 active site 698972000557 phosphorylation site [posttranslational modification] 698972000558 intermolecular recognition site; other site 698972000559 dimerization interface [polypeptide binding]; other site 698972000560 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698972000561 DNA binding site [nucleotide binding] 698972000562 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698972000563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698972000564 dimer interface [polypeptide binding]; other site 698972000565 phosphorylation site [posttranslational modification] 698972000566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698972000567 ATP binding site [chemical binding]; other site 698972000568 Mg2+ binding site [ion binding]; other site 698972000569 G-X-G motif; other site 698972000570 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 698972000571 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 698972000572 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 698972000573 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 698972000574 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698972000575 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 698972000576 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 698972000577 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698972000578 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 698972000579 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698972000580 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698972000581 Predicted membrane protein [Function unknown]; Region: COG1511 698972000582 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698972000583 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698972000584 putative active site [active] 698972000585 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 698972000586 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698972000587 putative active site [active] 698972000588 putative metal binding site [ion binding]; other site 698972000589 Yqey-like protein; Region: YqeY; pfam09424 698972000590 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698972000591 Transglycosylase; Region: Transgly; pfam00912 698972000592 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698972000593 PASTA domain; Region: PASTA; pfam03793 698972000594 Transcription factor WhiB; Region: Whib; pfam02467 698972000595 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 698972000596 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 698972000597 homotrimer interaction site [polypeptide binding]; other site 698972000598 putative active site [active] 698972000599 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698972000600 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698972000601 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698972000602 ligand binding site [chemical binding]; other site 698972000603 flexible hinge region; other site 698972000604 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698972000605 putative switch regulator; other site 698972000606 non-specific DNA interactions [nucleotide binding]; other site 698972000607 DNA binding site [nucleotide binding] 698972000608 sequence specific DNA binding site [nucleotide binding]; other site 698972000609 putative cAMP binding site [chemical binding]; other site 698972000610 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 698972000611 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698972000612 minor groove reading motif; other site 698972000613 helix-hairpin-helix signature motif; other site 698972000614 substrate binding pocket [chemical binding]; other site 698972000615 active site 698972000616 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 698972000617 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698972000618 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698972000619 catalytic residues [active] 698972000620 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 698972000621 putative active site [active] 698972000622 putative CoA binding site [chemical binding]; other site 698972000623 nudix motif; other site 698972000624 metal binding site [ion binding]; metal-binding site 698972000625 Colicin V production protein; Region: Colicin_V; pfam02674 698972000626 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 698972000627 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698972000628 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698972000629 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698972000630 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 698972000631 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698972000632 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698972000633 motif II; other site 698972000634 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 698972000635 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 698972000636 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 698972000637 ATP binding site [chemical binding]; other site 698972000638 Walker A motif; other site 698972000639 hexamer interface [polypeptide binding]; other site 698972000640 Walker B motif; other site 698972000641 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 698972000642 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 698972000643 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 698972000644 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698972000645 ATP binding site [chemical binding]; other site 698972000646 putative Mg++ binding site [ion binding]; other site 698972000647 nucleotide binding region [chemical binding]; other site 698972000648 helicase superfamily c-terminal domain; Region: HELICc; smart00490 698972000649 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 698972000650 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698972000651 DNA-binding site [nucleotide binding]; DNA binding site 698972000652 RNA-binding motif; other site 698972000653 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698972000654 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698972000655 Walker A/P-loop; other site 698972000656 ATP binding site [chemical binding]; other site 698972000657 Q-loop/lid; other site 698972000658 ABC transporter signature motif; other site 698972000659 Walker B; other site 698972000660 D-loop; other site 698972000661 H-loop/switch region; other site 698972000662 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698972000663 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698972000664 Walker A/P-loop; other site 698972000665 ATP binding site [chemical binding]; other site 698972000666 Q-loop/lid; other site 698972000667 ABC transporter signature motif; other site 698972000668 Walker B; other site 698972000669 D-loop; other site 698972000670 H-loop/switch region; other site 698972000671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972000672 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698972000673 putative substrate translocation pore; other site 698972000674 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698972000675 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 698972000676 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698972000677 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 698972000678 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698972000679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698972000680 dimer interface [polypeptide binding]; other site 698972000681 conserved gate region; other site 698972000682 putative PBP binding loops; other site 698972000683 ABC-ATPase subunit interface; other site 698972000684 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698972000685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698972000686 NAD(P) binding site [chemical binding]; other site 698972000687 active site 698972000688 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 698972000689 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 698972000690 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 698972000691 active site 698972000692 interdomain interaction site; other site 698972000693 putative metal-binding site [ion binding]; other site 698972000694 nucleotide binding site [chemical binding]; other site 698972000695 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 698972000696 domain I; other site 698972000697 DNA binding groove [nucleotide binding] 698972000698 phosphate binding site [ion binding]; other site 698972000699 domain II; other site 698972000700 domain III; other site 698972000701 nucleotide binding site [chemical binding]; other site 698972000702 catalytic site [active] 698972000703 domain IV; other site 698972000704 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698972000705 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698972000706 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 698972000707 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698972000708 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698972000709 active site 698972000710 Predicted membrane protein [Function unknown]; Region: COG1297 698972000711 putative oligopeptide transporter, OPT family; Region: TIGR00733 698972000712 Laminin G domain; Region: Laminin_G_2; pfam02210 698972000713 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698972000714 catalytic site [active] 698972000715 Asp-box motif; other site 698972000716 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698972000717 dimerization interface [polypeptide binding]; other site 698972000718 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698972000719 cyclase homology domain; Region: CHD; cd07302 698972000720 nucleotidyl binding site; other site 698972000721 metal binding site [ion binding]; metal-binding site 698972000722 dimer interface [polypeptide binding]; other site 698972000723 DNA polymerase III subunit delta'; Validated; Region: PRK07940 698972000724 DNA polymerase III subunit delta'; Validated; Region: PRK08485 698972000725 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 698972000726 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 698972000727 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698972000728 active site 698972000729 catalytic residues [active] 698972000730 DNA binding site [nucleotide binding] 698972000731 Int/Topo IB signature motif; other site 698972000732 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698972000733 MULE transposase domain; Region: MULE; pfam10551 698972000734 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 698972000735 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698972000736 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698972000737 Fic family protein [Function unknown]; Region: COG3177 698972000738 Fic/DOC family; Region: Fic; pfam02661 698972000739 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698972000740 Trypsin; Region: Trypsin; pfam00089 698972000741 active site 698972000742 Integrase core domain; Region: rve_3; cl15866 698972000743 Integrase core domain; Region: rve; pfam00665 698972000744 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698972000745 Integrase core domain; Region: rve; pfam00665 698972000746 Protein P3 of Potyviral polyprotein; Region: Potyvirid-P3; pfam13608 698972000747 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698972000748 Helix-turn-helix domain; Region: HTH_38; pfam13936 698972000749 potential frameshift: common BLAST hit: gi|296285263|ref|YP_003657305.1| transposase B 698972000750 Integrase core domain; Region: rve; pfam00665 698972000751 acyl-CoA synthetase; Validated; Region: PRK07788 698972000752 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698972000753 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698972000754 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698972000755 acyl-activating enzyme (AAE) consensus motif; other site 698972000756 acyl-activating enzyme (AAE) consensus motif; other site 698972000757 AMP binding site [chemical binding]; other site 698972000758 active site 698972000759 CoA binding site [chemical binding]; other site 698972000760 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 698972000761 active site 698972000762 catalytic triad [active] 698972000763 oxyanion hole [active] 698972000764 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 698972000765 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 698972000766 substrate binding site; other site 698972000767 tetramer interface; other site 698972000768 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 698972000769 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 698972000770 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 698972000771 NADP binding site [chemical binding]; other site 698972000772 active site 698972000773 putative substrate binding site [chemical binding]; other site 698972000774 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 698972000775 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 698972000776 NAD binding site [chemical binding]; other site 698972000777 substrate binding site [chemical binding]; other site 698972000778 homodimer interface [polypeptide binding]; other site 698972000779 active site 698972000780 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 698972000781 Zn binding site [ion binding]; other site 698972000782 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 698972000783 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698972000784 Putative esterase; Region: Esterase; pfam00756 698972000785 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 698972000786 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 698972000787 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698972000788 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698972000789 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698972000790 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698972000791 non-specific DNA binding site [nucleotide binding]; other site 698972000792 salt bridge; other site 698972000793 sequence-specific DNA binding site [nucleotide binding]; other site 698972000794 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 698972000795 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698972000796 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 698972000797 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 698972000798 putative Iron-sulfur protein interface [polypeptide binding]; other site 698972000799 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 698972000800 proximal heme binding site [chemical binding]; other site 698972000801 distal heme binding site [chemical binding]; other site 698972000802 putative dimer interface [polypeptide binding]; other site 698972000803 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 698972000804 L-aspartate oxidase; Provisional; Region: PRK06175 698972000805 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 698972000806 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 698972000807 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 698972000808 Predicted membrane protein [Function unknown]; Region: COG2733 698972000809 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 698972000810 Class I aldolases; Region: Aldolase_Class_I; cd00945 698972000811 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698972000812 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 698972000813 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698972000814 FeS/SAM binding site; other site 698972000815 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 698972000816 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698972000817 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 698972000818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698972000819 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 698972000820 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 698972000821 FAD binding domain; Region: FAD_binding_4; pfam01565 698972000822 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 698972000823 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698972000824 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698972000825 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698972000826 acyl-activating enzyme (AAE) consensus motif; other site 698972000827 AMP binding site [chemical binding]; other site 698972000828 active site 698972000829 CoA binding site [chemical binding]; other site 698972000830 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698972000831 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698972000832 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698972000833 acyl-activating enzyme (AAE) consensus motif; other site 698972000834 AMP binding site [chemical binding]; other site 698972000835 active site 698972000836 CoA binding site [chemical binding]; other site 698972000837 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 698972000838 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 698972000839 putative ADP-binding pocket [chemical binding]; other site 698972000840 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698972000841 catalytic core [active] 698972000842 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698972000843 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698972000844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698972000845 dimer interface [polypeptide binding]; other site 698972000846 phosphorylation site [posttranslational modification] 698972000847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698972000848 ATP binding site [chemical binding]; other site 698972000849 Mg2+ binding site [ion binding]; other site 698972000850 G-X-G motif; other site 698972000851 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698972000852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698972000853 active site 698972000854 phosphorylation site [posttranslational modification] 698972000855 intermolecular recognition site; other site 698972000856 dimerization interface [polypeptide binding]; other site 698972000857 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698972000858 DNA binding site [nucleotide binding] 698972000859 exopolyphosphatase; Region: exo_poly_only; TIGR03706 698972000860 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698972000861 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 698972000862 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 698972000863 DNA binding domain, excisionase family; Region: excise; TIGR01764 698972000864 Thioredoxin; Region: Thioredoxin_4; cl17273 698972000865 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698972000866 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698972000867 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 698972000868 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698972000869 motif II; other site 698972000870 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 698972000871 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 698972000872 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 698972000873 tRNA; other site 698972000874 putative tRNA binding site [nucleotide binding]; other site 698972000875 putative NADP binding site [chemical binding]; other site 698972000876 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 698972000877 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 698972000878 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 698972000879 domain interfaces; other site 698972000880 active site 698972000881 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 698972000882 active site 698972000883 homodimer interface [polypeptide binding]; other site 698972000884 SAM binding site [chemical binding]; other site 698972000885 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 698972000886 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 698972000887 active site 698972000888 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 698972000889 dimer interface [polypeptide binding]; other site 698972000890 active site 698972000891 Schiff base residues; other site 698972000892 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 698972000893 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698972000894 Predicted membrane protein [Function unknown]; Region: COG2311 698972000895 Protein of unknown function (DUF418); Region: DUF418; pfam04235 698972000896 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 698972000897 substrate binding site [chemical binding]; other site 698972000898 active site 698972000899 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 698972000900 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 698972000901 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698972000902 inhibitor-cofactor binding pocket; inhibition site 698972000903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698972000904 catalytic residue [active] 698972000905 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698972000906 catalytic core [active] 698972000907 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698972000908 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698972000909 catalytic residues [active] 698972000910 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698972000911 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698972000912 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 698972000913 ResB-like family; Region: ResB; pfam05140 698972000914 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 698972000915 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698972000916 dimerization interface [polypeptide binding]; other site 698972000917 putative DNA binding site [nucleotide binding]; other site 698972000918 putative Zn2+ binding site [ion binding]; other site 698972000919 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 698972000920 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 698972000921 UbiA prenyltransferase family; Region: UbiA; pfam01040 698972000922 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698972000923 active site 698972000924 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698972000925 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 698972000926 acyl-activating enzyme (AAE) consensus motif; other site 698972000927 AMP binding site [chemical binding]; other site 698972000928 active site 698972000929 CoA binding site [chemical binding]; other site 698972000930 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 698972000931 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698972000932 substrate binding site [chemical binding]; other site 698972000933 oxyanion hole (OAH) forming residues; other site 698972000934 trimer interface [polypeptide binding]; other site 698972000935 O-succinylbenzoate synthase; Provisional; Region: PRK02901 698972000936 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 698972000937 active site 698972000938 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 698972000939 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 698972000940 dimer interface [polypeptide binding]; other site 698972000941 tetramer interface [polypeptide binding]; other site 698972000942 PYR/PP interface [polypeptide binding]; other site 698972000943 TPP binding site [chemical binding]; other site 698972000944 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 698972000945 TPP-binding site; other site 698972000946 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 698972000947 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698972000948 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 698972000949 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 698972000950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698972000951 S-adenosylmethionine binding site [chemical binding]; other site 698972000952 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 698972000953 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 698972000954 NAD binding site [chemical binding]; other site 698972000955 dimer interface [polypeptide binding]; other site 698972000956 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698972000957 substrate binding site [chemical binding]; other site 698972000958 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 698972000959 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698972000960 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698972000961 substrate binding pocket [chemical binding]; other site 698972000962 chain length determination region; other site 698972000963 substrate-Mg2+ binding site; other site 698972000964 catalytic residues [active] 698972000965 aspartate-rich region 1; other site 698972000966 active site lid residues [active] 698972000967 aspartate-rich region 2; other site 698972000968 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 698972000969 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 698972000970 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 698972000971 putative homodimer interface [polypeptide binding]; other site 698972000972 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 698972000973 heterodimer interface [polypeptide binding]; other site 698972000974 homodimer interface [polypeptide binding]; other site 698972000975 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 698972000976 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 698972000977 23S rRNA interface [nucleotide binding]; other site 698972000978 L7/L12 interface [polypeptide binding]; other site 698972000979 putative thiostrepton binding site; other site 698972000980 L25 interface [polypeptide binding]; other site 698972000981 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 698972000982 mRNA/rRNA interface [nucleotide binding]; other site 698972000983 putative transposase OrfB; Reviewed; Region: PHA02517 698972000984 HTH-like domain; Region: HTH_21; pfam13276 698972000985 Integrase core domain; Region: rve; pfam00665 698972000986 Integrase core domain; Region: rve_2; pfam13333 698972000987 Homeodomain-like domain; Region: HTH_23; cl17451 698972000988 Helix-turn-helix domain; Region: HTH_28; pfam13518 698972000989 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 698972000990 23S rRNA interface [nucleotide binding]; other site 698972000991 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 698972000992 50S ribosomal protein L7/L12; Reviewed; Region: rplL; PRK00157 698972000993 L11 interface [polypeptide binding]; other site 698972000994 putative EF-Tu interaction site [polypeptide binding]; other site 698972000995 putative EF-G interaction site [polypeptide binding]; other site 698972000996 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 698972000997 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698972000998 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698972000999 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698972001000 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698972001001 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698972001002 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 698972001003 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698972001004 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698972001005 ABC-ATPase subunit interface; other site 698972001006 dimer interface [polypeptide binding]; other site 698972001007 putative PBP binding regions; other site 698972001008 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698972001009 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698972001010 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698972001011 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698972001012 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 698972001013 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 698972001014 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 698972001015 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 698972001016 RPB1 interaction site [polypeptide binding]; other site 698972001017 RPB10 interaction site [polypeptide binding]; other site 698972001018 RPB11 interaction site [polypeptide binding]; other site 698972001019 RPB3 interaction site [polypeptide binding]; other site 698972001020 RPB12 interaction site [polypeptide binding]; other site 698972001021 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 698972001022 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 698972001023 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 698972001024 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 698972001025 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 698972001026 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698972001027 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 698972001028 G-loop; other site 698972001029 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698972001030 DNA binding site [nucleotide binding] 698972001031 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 698972001032 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698972001033 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698972001034 Walker A/P-loop; other site 698972001035 ATP binding site [chemical binding]; other site 698972001036 Q-loop/lid; other site 698972001037 ABC transporter signature motif; other site 698972001038 Walker B; other site 698972001039 D-loop; other site 698972001040 H-loop/switch region; other site 698972001041 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 698972001042 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698972001043 FeS/SAM binding site; other site 698972001044 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 698972001045 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698972001046 Histidine kinase; Region: HisKA_3; pfam07730 698972001047 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698972001048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698972001049 active site 698972001050 phosphorylation site [posttranslational modification] 698972001051 intermolecular recognition site; other site 698972001052 dimerization interface [polypeptide binding]; other site 698972001053 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698972001054 DNA binding residues [nucleotide binding] 698972001055 dimerization interface [polypeptide binding]; other site 698972001056 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698972001057 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 698972001058 Walker A/P-loop; other site 698972001059 ATP binding site [chemical binding]; other site 698972001060 Q-loop/lid; other site 698972001061 ABC transporter signature motif; other site 698972001062 Walker B; other site 698972001063 D-loop; other site 698972001064 H-loop/switch region; other site 698972001065 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 698972001066 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 698972001067 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698972001068 TIGR03943 family protein; Region: TIGR03943 698972001069 Predicted permeases [General function prediction only]; Region: COG0701 698972001070 Radical SAM superfamily; Region: Radical_SAM; pfam04055 698972001071 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698972001072 FeS/SAM binding site; other site 698972001073 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 698972001074 Class III ribonucleotide reductase; Region: RNR_III; cd01675 698972001075 effector binding site; other site 698972001076 active site 698972001077 Zn binding site [ion binding]; other site 698972001078 glycine loop; other site 698972001079 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 698972001080 S17 interaction site [polypeptide binding]; other site 698972001081 S8 interaction site; other site 698972001082 16S rRNA interaction site [nucleotide binding]; other site 698972001083 streptomycin interaction site [chemical binding]; other site 698972001084 23S rRNA interaction site [nucleotide binding]; other site 698972001085 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 698972001086 30S ribosomal protein S7; Validated; Region: PRK05302 698972001087 elongation factor G; Reviewed; Region: PRK00007 698972001088 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 698972001089 G1 box; other site 698972001090 putative GEF interaction site [polypeptide binding]; other site 698972001091 GTP/Mg2+ binding site [chemical binding]; other site 698972001092 Switch I region; other site 698972001093 G2 box; other site 698972001094 G3 box; other site 698972001095 Switch II region; other site 698972001096 G4 box; other site 698972001097 G5 box; other site 698972001098 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 698972001099 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 698972001100 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 698972001101 elongation factor Tu; Reviewed; Region: PRK00049 698972001102 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 698972001103 G1 box; other site 698972001104 GEF interaction site [polypeptide binding]; other site 698972001105 GTP/Mg2+ binding site [chemical binding]; other site 698972001106 Switch I region; other site 698972001107 G2 box; other site 698972001108 G3 box; other site 698972001109 Switch II region; other site 698972001110 G4 box; other site 698972001111 G5 box; other site 698972001112 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 698972001113 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 698972001114 Antibiotic Binding Site [chemical binding]; other site 698972001115 Predicted membrane protein [Function unknown]; Region: COG2323 698972001116 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 698972001117 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 698972001118 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 698972001119 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 698972001120 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 698972001121 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 698972001122 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 698972001123 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 698972001124 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 698972001125 putative translocon binding site; other site 698972001126 protein-rRNA interface [nucleotide binding]; other site 698972001127 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 698972001128 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 698972001129 G-X-X-G motif; other site 698972001130 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 698972001131 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 698972001132 23S rRNA interface [nucleotide binding]; other site 698972001133 5S rRNA interface [nucleotide binding]; other site 698972001134 putative antibiotic binding site [chemical binding]; other site 698972001135 L25 interface [polypeptide binding]; other site 698972001136 L27 interface [polypeptide binding]; other site 698972001137 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 698972001138 putative translocon interaction site; other site 698972001139 23S rRNA interface [nucleotide binding]; other site 698972001140 signal recognition particle (SRP54) interaction site; other site 698972001141 L23 interface [polypeptide binding]; other site 698972001142 trigger factor interaction site; other site 698972001143 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 698972001144 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698972001145 HlyD family secretion protein; Region: HlyD_3; pfam13437 698972001146 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698972001147 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698972001148 Walker A/P-loop; other site 698972001149 ATP binding site [chemical binding]; other site 698972001150 Q-loop/lid; other site 698972001151 ABC transporter signature motif; other site 698972001152 Walker B; other site 698972001153 D-loop; other site 698972001154 H-loop/switch region; other site 698972001155 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698972001156 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698972001157 FtsX-like permease family; Region: FtsX; pfam02687 698972001158 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 698972001159 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 698972001160 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 698972001161 RNA binding site [nucleotide binding]; other site 698972001162 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 698972001163 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 698972001164 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 698972001165 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 698972001166 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 698972001167 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698972001168 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698972001169 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698972001170 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698972001171 active site 698972001172 homotetramer interface [polypeptide binding]; other site 698972001173 homodimer interface [polypeptide binding]; other site 698972001174 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 698972001175 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698972001176 ATP binding site [chemical binding]; other site 698972001177 substrate interface [chemical binding]; other site 698972001178 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698972001179 active site residue [active] 698972001180 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698972001181 MPT binding site; other site 698972001182 trimer interface [polypeptide binding]; other site 698972001183 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 698972001184 MoaE homodimer interface [polypeptide binding]; other site 698972001185 MoaD interaction [polypeptide binding]; other site 698972001186 active site residues [active] 698972001187 Ubiquitin-like proteins; Region: UBQ; cl00155 698972001188 charged pocket; other site 698972001189 hydrophobic patch; other site 698972001190 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698972001191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698972001192 dimer interface [polypeptide binding]; other site 698972001193 conserved gate region; other site 698972001194 putative PBP binding loops; other site 698972001195 ABC-ATPase subunit interface; other site 698972001196 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972001197 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698972001198 Walker A/P-loop; other site 698972001199 ATP binding site [chemical binding]; other site 698972001200 Q-loop/lid; other site 698972001201 ABC transporter signature motif; other site 698972001202 Walker B; other site 698972001203 D-loop; other site 698972001204 H-loop/switch region; other site 698972001205 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 698972001206 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 698972001207 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 698972001208 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 698972001209 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 698972001210 [4Fe-4S] binding site [ion binding]; other site 698972001211 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698972001212 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698972001213 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698972001214 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 698972001215 molybdopterin cofactor binding site; other site 698972001216 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 698972001217 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 698972001218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972001219 putative substrate translocation pore; other site 698972001220 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698972001221 MPT binding site; other site 698972001222 trimer interface [polypeptide binding]; other site 698972001223 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 698972001224 GTP binding site; other site 698972001225 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 698972001226 trimer interface [polypeptide binding]; other site 698972001227 dimer interface [polypeptide binding]; other site 698972001228 putative active site [active] 698972001229 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698972001230 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698972001231 dimer interface [polypeptide binding]; other site 698972001232 putative functional site; other site 698972001233 putative MPT binding site; other site 698972001234 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 698972001235 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698972001236 FeS/SAM binding site; other site 698972001237 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 698972001238 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 698972001239 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698972001240 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 698972001241 Predicted ATPase [General function prediction only]; Region: COG4637 698972001242 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972001243 Walker A/P-loop; other site 698972001244 ATP binding site [chemical binding]; other site 698972001245 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698972001246 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698972001247 inhibitor site; inhibition site 698972001248 active site 698972001249 dimer interface [polypeptide binding]; other site 698972001250 catalytic residue [active] 698972001251 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698972001252 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698972001253 Walker A/P-loop; other site 698972001254 ATP binding site [chemical binding]; other site 698972001255 Q-loop/lid; other site 698972001256 ABC transporter signature motif; other site 698972001257 Walker B; other site 698972001258 D-loop; other site 698972001259 H-loop/switch region; other site 698972001260 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698972001261 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698972001262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698972001263 dimer interface [polypeptide binding]; other site 698972001264 conserved gate region; other site 698972001265 putative PBP binding loops; other site 698972001266 ABC-ATPase subunit interface; other site 698972001267 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698972001268 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698972001269 Walker A/P-loop; other site 698972001270 ATP binding site [chemical binding]; other site 698972001271 Q-loop/lid; other site 698972001272 ABC transporter signature motif; other site 698972001273 Walker B; other site 698972001274 D-loop; other site 698972001275 H-loop/switch region; other site 698972001276 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698972001277 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698972001278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698972001279 dimer interface [polypeptide binding]; other site 698972001280 conserved gate region; other site 698972001281 putative PBP binding loops; other site 698972001282 ABC-ATPase subunit interface; other site 698972001283 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 698972001284 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698972001285 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698972001286 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698972001287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698972001288 DNA-binding site [nucleotide binding]; DNA binding site 698972001289 FCD domain; Region: FCD; pfam07729 698972001290 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698972001291 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698972001292 nucleotide binding site [chemical binding]; other site 698972001293 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 698972001294 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 698972001295 putative active site cavity [active] 698972001296 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 698972001297 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 698972001298 active site 698972001299 dimer interface [polypeptide binding]; other site 698972001300 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698972001301 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 698972001302 active site 698972001303 trimer interface [polypeptide binding]; other site 698972001304 allosteric site; other site 698972001305 active site lid [active] 698972001306 hexamer (dimer of trimers) interface [polypeptide binding]; other site 698972001307 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 698972001308 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 698972001309 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698972001310 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698972001311 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 698972001312 5S rRNA interface [nucleotide binding]; other site 698972001313 L27 interface [polypeptide binding]; other site 698972001314 23S rRNA interface [nucleotide binding]; other site 698972001315 L5 interface [polypeptide binding]; other site 698972001316 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 698972001317 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 698972001318 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 698972001319 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 698972001320 23S rRNA binding site [nucleotide binding]; other site 698972001321 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 698972001322 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 698972001323 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 698972001324 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 698972001325 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698972001326 active site 698972001327 catalytic site [active] 698972001328 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698972001329 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698972001330 active site 698972001331 catalytic site [active] 698972001332 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698972001333 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698972001334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698972001335 dimer interface [polypeptide binding]; other site 698972001336 conserved gate region; other site 698972001337 putative PBP binding loops; other site 698972001338 ABC-ATPase subunit interface; other site 698972001339 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698972001340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698972001341 dimer interface [polypeptide binding]; other site 698972001342 conserved gate region; other site 698972001343 putative PBP binding loops; other site 698972001344 ABC-ATPase subunit interface; other site 698972001345 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 698972001346 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698972001347 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698972001348 Walker A/P-loop; other site 698972001349 ATP binding site [chemical binding]; other site 698972001350 Q-loop/lid; other site 698972001351 ABC transporter signature motif; other site 698972001352 Walker B; other site 698972001353 D-loop; other site 698972001354 H-loop/switch region; other site 698972001355 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 698972001356 SecY translocase; Region: SecY; pfam00344 698972001357 adenylate kinase; Reviewed; Region: adk; PRK00279 698972001358 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 698972001359 AMP-binding site [chemical binding]; other site 698972001360 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 698972001361 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698972001362 active site 698972001363 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698972001364 catalytic site [active] 698972001365 BNR repeat-like domain; Region: BNR_2; pfam13088 698972001366 Asp-box motif; other site 698972001367 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698972001368 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 698972001369 rRNA binding site [nucleotide binding]; other site 698972001370 predicted 30S ribosome binding site; other site 698972001371 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 698972001372 30S ribosomal protein S13; Region: bact_S13; TIGR03631 698972001373 30S ribosomal protein S11; Validated; Region: PRK05309 698972001374 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 698972001375 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 698972001376 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698972001377 RNA binding surface [nucleotide binding]; other site 698972001378 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 698972001379 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 698972001380 alphaNTD - beta interaction site [polypeptide binding]; other site 698972001381 alphaNTD homodimer interface [polypeptide binding]; other site 698972001382 alphaNTD - beta' interaction site [polypeptide binding]; other site 698972001383 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 698972001384 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 698972001385 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 698972001386 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 698972001387 dimerization interface 3.5A [polypeptide binding]; other site 698972001388 active site 698972001389 Protein of unknown function (DUF690); Region: DUF690; cl04939 698972001390 TIGR02611 family protein; Region: TIGR02611 698972001391 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 698972001392 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 698972001393 active site 698972001394 catalytic residues [active] 698972001395 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 698972001396 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 698972001397 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698972001398 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 698972001399 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698972001400 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698972001401 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 698972001402 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 698972001403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 698972001404 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 698972001405 23S rRNA interface [nucleotide binding]; other site 698972001406 L3 interface [polypeptide binding]; other site 698972001407 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 698972001408 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 698972001409 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 698972001410 active site 698972001411 substrate binding site [chemical binding]; other site 698972001412 metal binding site [ion binding]; metal-binding site 698972001413 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 698972001414 alanine racemase; Reviewed; Region: alr; PRK00053 698972001415 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 698972001416 active site 698972001417 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698972001418 dimer interface [polypeptide binding]; other site 698972001419 substrate binding site [chemical binding]; other site 698972001420 catalytic residues [active] 698972001421 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 698972001422 Predicted permease [General function prediction only]; Region: COG2985 698972001423 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698972001424 TrkA-C domain; Region: TrkA_C; pfam02080 698972001425 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698972001426 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698972001427 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 698972001428 Glycoprotease family; Region: Peptidase_M22; pfam00814 698972001429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698972001430 Coenzyme A binding pocket [chemical binding]; other site 698972001431 UGMP family protein; Validated; Region: PRK09604 698972001432 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 698972001433 oligomerisation interface [polypeptide binding]; other site 698972001434 mobile loop; other site 698972001435 roof hairpin; other site 698972001436 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698972001437 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698972001438 ring oligomerisation interface [polypeptide binding]; other site 698972001439 ATP/Mg binding site [chemical binding]; other site 698972001440 stacking interactions; other site 698972001441 hinge regions; other site 698972001442 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 698972001443 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698972001444 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698972001445 DNA binding residues [nucleotide binding] 698972001446 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 698972001447 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698972001448 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 698972001449 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 698972001450 active site 698972001451 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 698972001452 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698972001453 phosphate binding site [ion binding]; other site 698972001454 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698972001455 siderophore binding site; other site 698972001456 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698972001457 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698972001458 dimer interface [polypeptide binding]; other site 698972001459 putative PBP binding regions; other site 698972001460 ABC-ATPase subunit interface; other site 698972001461 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698972001462 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698972001463 ABC-ATPase subunit interface; other site 698972001464 dimer interface [polypeptide binding]; other site 698972001465 putative PBP binding regions; other site 698972001466 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698972001467 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698972001468 Walker A/P-loop; other site 698972001469 ATP binding site [chemical binding]; other site 698972001470 Q-loop/lid; other site 698972001471 ABC transporter signature motif; other site 698972001472 Walker B; other site 698972001473 D-loop; other site 698972001474 H-loop/switch region; other site 698972001475 IucA / IucC family; Region: IucA_IucC; pfam04183 698972001476 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698972001477 IucA / IucC family; Region: IucA_IucC; pfam04183 698972001478 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698972001479 H+ Antiporter protein; Region: 2A0121; TIGR00900 698972001480 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 698972001481 EamA-like transporter family; Region: EamA; pfam00892 698972001482 GMP synthase; Reviewed; Region: guaA; PRK00074 698972001483 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 698972001484 AMP/PPi binding site [chemical binding]; other site 698972001485 candidate oxyanion hole; other site 698972001486 catalytic triad [active] 698972001487 potential glutamine specificity residues [chemical binding]; other site 698972001488 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 698972001489 ATP Binding subdomain [chemical binding]; other site 698972001490 Ligand Binding sites [chemical binding]; other site 698972001491 Dimerization subdomain; other site 698972001492 PspC domain; Region: PspC; pfam04024 698972001493 PspC domain; Region: PspC; pfam04024 698972001494 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698972001495 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698972001496 ATP binding site [chemical binding]; other site 698972001497 Mg2+ binding site [ion binding]; other site 698972001498 G-X-G motif; other site 698972001499 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698972001500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698972001501 active site 698972001502 phosphorylation site [posttranslational modification] 698972001503 intermolecular recognition site; other site 698972001504 dimerization interface [polypeptide binding]; other site 698972001505 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698972001506 DNA binding residues [nucleotide binding] 698972001507 dimerization interface [polypeptide binding]; other site 698972001508 potential frameshift: common BLAST hit: gi|38233680|ref|NP_939447.1| iron transport system exported solute-binding component 698972001509 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698972001510 intersubunit interface [polypeptide binding]; other site 698972001511 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698972001512 DNA Polymerase Y-family; Region: PolY_like; cd03468 698972001513 active site 698972001514 DNA binding site [nucleotide binding] 698972001515 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 698972001516 putative dimer interface [polypeptide binding]; other site 698972001517 putative [2Fe-2S] cluster binding site [ion binding]; other site 698972001518 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698972001519 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698972001520 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698972001521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698972001522 dimer interface [polypeptide binding]; other site 698972001523 conserved gate region; other site 698972001524 ABC-ATPase subunit interface; other site 698972001525 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 698972001526 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 698972001527 Walker A/P-loop; other site 698972001528 ATP binding site [chemical binding]; other site 698972001529 Q-loop/lid; other site 698972001530 ABC transporter signature motif; other site 698972001531 Walker B; other site 698972001532 D-loop; other site 698972001533 H-loop/switch region; other site 698972001534 NIL domain; Region: NIL; cl09633 698972001535 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698972001536 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 698972001537 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698972001538 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 698972001539 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 698972001540 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 698972001541 active site 698972001542 PHP Thumb interface [polypeptide binding]; other site 698972001543 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698972001544 generic binding surface II; other site 698972001545 generic binding surface I; other site 698972001546 Uncharacterized conserved protein [Function unknown]; Region: COG3402 698972001547 Predicted membrane protein [Function unknown]; Region: COG3428 698972001548 Bacterial PH domain; Region: DUF304; pfam03703 698972001549 Bacterial PH domain; Region: DUF304; pfam03703 698972001550 Bacterial PH domain; Region: DUF304; pfam03703 698972001551 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698972001552 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698972001553 intersubunit interface [polypeptide binding]; other site 698972001554 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698972001555 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698972001556 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698972001557 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698972001558 dimer interface [polypeptide binding]; other site 698972001559 putative PBP binding regions; other site 698972001560 ABC-ATPase subunit interface; other site 698972001561 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698972001562 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698972001563 ABC-ATPase subunit interface; other site 698972001564 dimer interface [polypeptide binding]; other site 698972001565 putative PBP binding regions; other site 698972001566 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698972001567 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698972001568 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698972001569 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 698972001570 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 698972001571 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 698972001572 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 698972001573 homodimer interface [polypeptide binding]; other site 698972001574 NADP binding site [chemical binding]; other site 698972001575 substrate binding site [chemical binding]; other site 698972001576 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 698972001577 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698972001578 active site 698972001579 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 698972001580 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 698972001581 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698972001582 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698972001583 intersubunit interface [polypeptide binding]; other site 698972001584 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698972001585 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698972001586 ABC-ATPase subunit interface; other site 698972001587 dimer interface [polypeptide binding]; other site 698972001588 putative PBP binding regions; other site 698972001589 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 698972001590 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698972001591 Walker A/P-loop; other site 698972001592 ATP binding site [chemical binding]; other site 698972001593 Q-loop/lid; other site 698972001594 ABC transporter signature motif; other site 698972001595 Walker B; other site 698972001596 D-loop; other site 698972001597 H-loop/switch region; other site 698972001598 Htaa; Region: HtaA; pfam04213 698972001599 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 698972001600 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698972001601 homodimer interface [polypeptide binding]; other site 698972001602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698972001603 substrate-cofactor binding pocket; other site 698972001604 catalytic residue [active] 698972001605 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 698972001606 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 698972001607 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698972001608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972001609 putative substrate translocation pore; other site 698972001610 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698972001611 putative catalytic site [active] 698972001612 putative metal binding site [ion binding]; other site 698972001613 putative phosphate binding site [ion binding]; other site 698972001614 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 698972001615 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 698972001616 active site 698972001617 HIGH motif; other site 698972001618 dimer interface [polypeptide binding]; other site 698972001619 KMSKS motif; other site 698972001620 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 698972001621 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698972001622 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698972001623 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698972001624 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698972001625 NlpC/P60 family; Region: NLPC_P60; pfam00877 698972001626 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698972001627 active site 698972001628 putative transposase OrfB; Reviewed; Region: PHA02517 698972001629 HTH-like domain; Region: HTH_21; pfam13276 698972001630 Integrase core domain; Region: rve; pfam00665 698972001631 Integrase core domain; Region: rve_2; pfam13333 698972001632 Homeodomain-like domain; Region: HTH_23; cl17451 698972001633 Helix-turn-helix domain; Region: HTH_28; pfam13518 698972001634 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698972001635 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698972001636 non-specific DNA binding site [nucleotide binding]; other site 698972001637 salt bridge; other site 698972001638 sequence-specific DNA binding site [nucleotide binding]; other site 698972001639 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698972001640 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 698972001641 metal binding site [ion binding]; metal-binding site 698972001642 putative dimer interface [polypeptide binding]; other site 698972001643 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 698972001644 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698972001645 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698972001646 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698972001647 pyruvate carboxylase; Reviewed; Region: PRK12999 698972001648 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698972001649 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698972001650 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698972001651 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698972001652 active site 698972001653 catalytic residues [active] 698972001654 metal binding site [ion binding]; metal-binding site 698972001655 homodimer binding site [polypeptide binding]; other site 698972001656 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698972001657 carboxyltransferase (CT) interaction site; other site 698972001658 biotinylation site [posttranslational modification]; other site 698972001659 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 698972001660 ADP-ribose binding site [chemical binding]; other site 698972001661 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 698972001662 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698972001663 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 698972001664 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698972001665 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698972001666 carboxyltransferase (CT) interaction site; other site 698972001667 biotinylation site [posttranslational modification]; other site 698972001668 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698972001669 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698972001670 active site residue [active] 698972001671 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698972001672 active site residue [active] 698972001673 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698972001674 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 698972001675 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 698972001676 active site 698972001677 dimer interface [polypeptide binding]; other site 698972001678 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 698972001679 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698972001680 substrate binding site [chemical binding]; other site 698972001681 dimer interface [polypeptide binding]; other site 698972001682 ATP binding site [chemical binding]; other site 698972001683 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698972001684 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698972001685 DNA binding site [nucleotide binding] 698972001686 domain linker motif; other site 698972001687 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 698972001688 dimerization interface [polypeptide binding]; other site 698972001689 putative ligand binding site [chemical binding]; other site 698972001690 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 698972001691 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698972001692 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698972001693 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698972001694 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698972001695 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698972001696 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698972001697 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 698972001698 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 698972001699 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 698972001700 ATP-grasp domain; Region: ATP-grasp; pfam02222 698972001701 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 698972001702 Uncharacterized conserved protein [Function unknown]; Region: COG1434 698972001703 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698972001704 putative active site [active] 698972001705 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 698972001706 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 698972001707 HupF/HypC family; Region: HupF_HypC; pfam01455 698972001708 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 698972001709 dimerization interface [polypeptide binding]; other site 698972001710 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 698972001711 ATP binding site [chemical binding]; other site 698972001712 Acylphosphatase; Region: Acylphosphatase; pfam00708 698972001713 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 698972001714 HypF finger; Region: zf-HYPF; pfam07503 698972001715 HypF finger; Region: zf-HYPF; pfam07503 698972001716 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 698972001717 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 698972001718 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698972001719 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 698972001720 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 698972001721 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 698972001722 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 698972001723 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 698972001724 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 698972001725 putative substrate-binding site; other site 698972001726 nickel binding site [ion binding]; other site 698972001727 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 698972001728 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 698972001729 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 698972001730 HupF/HypC family; Region: HupF_HypC; pfam01455 698972001731 TIGR03089 family protein; Region: TIGR03089 698972001732 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698972001733 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698972001734 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698972001735 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698972001736 active site 698972001737 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698972001738 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 698972001739 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 698972001740 active site 698972001741 Substrate binding site; other site 698972001742 Mg++ binding site; other site 698972001743 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698972001744 putative trimer interface [polypeptide binding]; other site 698972001745 putative CoA binding site [chemical binding]; other site 698972001746 Transcription factor WhiB; Region: Whib; pfam02467 698972001747 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 698972001748 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 698972001749 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 698972001750 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 698972001751 active site 698972001752 substrate binding site [chemical binding]; other site 698972001753 metal binding site [ion binding]; metal-binding site 698972001754 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 698972001755 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698972001756 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 698972001757 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 698972001758 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 698972001759 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 698972001760 homotetramer interface [polypeptide binding]; other site 698972001761 ligand binding site [chemical binding]; other site 698972001762 catalytic site [active] 698972001763 NAD binding site [chemical binding]; other site 698972001764 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 698972001765 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 698972001766 TMP-binding site; other site 698972001767 ATP-binding site [chemical binding]; other site 698972001768 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698972001769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698972001770 active site 698972001771 phosphorylation site [posttranslational modification] 698972001772 intermolecular recognition site; other site 698972001773 dimerization interface [polypeptide binding]; other site 698972001774 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698972001775 DNA binding site [nucleotide binding] 698972001776 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698972001777 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698972001778 dimerization interface [polypeptide binding]; other site 698972001779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698972001780 dimer interface [polypeptide binding]; other site 698972001781 phosphorylation site [posttranslational modification] 698972001782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698972001783 ATP binding site [chemical binding]; other site 698972001784 Mg2+ binding site [ion binding]; other site 698972001785 G-X-G motif; other site 698972001786 lipoprotein LpqB; Provisional; Region: PRK13616 698972001787 Sporulation and spore germination; Region: Germane; pfam10646 698972001788 comF family protein; Region: comF; TIGR00201 698972001789 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698972001790 active site 698972001791 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 698972001792 30S subunit binding site; other site 698972001793 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 698972001794 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698972001795 ATP binding site [chemical binding]; other site 698972001796 putative Mg++ binding site [ion binding]; other site 698972001797 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 698972001798 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698972001799 nucleotide binding region [chemical binding]; other site 698972001800 ATP-binding site [chemical binding]; other site 698972001801 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 698972001802 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 698972001803 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698972001804 FAD binding pocket [chemical binding]; other site 698972001805 FAD binding motif [chemical binding]; other site 698972001806 phosphate binding motif [ion binding]; other site 698972001807 beta-alpha-beta structure motif; other site 698972001808 NAD binding pocket [chemical binding]; other site 698972001809 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698972001810 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 698972001811 catalytic loop [active] 698972001812 iron binding site [ion binding]; other site 698972001813 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 698972001814 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 698972001815 putative di-iron ligands [ion binding]; other site 698972001816 Predicted GTPases [General function prediction only]; Region: COG1162 698972001817 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 698972001818 GTPase/Zn-binding domain interface [polypeptide binding]; other site 698972001819 GTP/Mg2+ binding site [chemical binding]; other site 698972001820 G4 box; other site 698972001821 G5 box; other site 698972001822 G1 box; other site 698972001823 Switch I region; other site 698972001824 G2 box; other site 698972001825 G3 box; other site 698972001826 Switch II region; other site 698972001827 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 698972001828 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 698972001829 hinge; other site 698972001830 active site 698972001831 Uncharacterized conserved protein [Function unknown]; Region: COG2135 698972001832 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 698972001833 putative deacylase active site [active] 698972001834 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 698972001835 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698972001836 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698972001837 DNA binding residues [nucleotide binding] 698972001838 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 698972001839 Transcription factor WhiB; Region: Whib; pfam02467 698972001840 PQQ-like domain; Region: PQQ_2; pfam13360 698972001841 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698972001842 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698972001843 ATP binding site [chemical binding]; other site 698972001844 putative Mg++ binding site [ion binding]; other site 698972001845 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698972001846 nucleotide binding region [chemical binding]; other site 698972001847 ATP-binding site [chemical binding]; other site 698972001848 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 698972001849 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 698972001850 TIGR02569 family protein; Region: TIGR02569_actnb 698972001851 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698972001852 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698972001853 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698972001854 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698972001855 Part of AAA domain; Region: AAA_19; pfam13245 698972001856 Family description; Region: UvrD_C_2; pfam13538 698972001857 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698972001858 Ion channel; Region: Ion_trans_2; pfam07885 698972001859 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 698972001860 TrkA-N domain; Region: TrkA_N; pfam02254 698972001861 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 698972001862 putative NADH binding site [chemical binding]; other site 698972001863 putative active site [active] 698972001864 nudix motif; other site 698972001865 putative metal binding site [ion binding]; other site 698972001866 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 698972001867 Part of AAA domain; Region: AAA_19; pfam13245 698972001868 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698972001869 Family description; Region: UvrD_C_2; pfam13538 698972001870 HRDC domain; Region: HRDC; pfam00570 698972001871 Protein of unknown function DUF45; Region: DUF45; pfam01863 698972001872 putative hydrolase; Region: TIGR03624 698972001873 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 698972001874 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698972001875 hypothetical protein; Validated; Region: PRK00068 698972001876 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 698972001877 HsdM N-terminal domain; Region: HsdM_N; pfam12161 698972001878 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 698972001879 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698972001880 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 698972001881 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698972001882 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698972001883 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 698972001884 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698972001885 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698972001886 ATP binding site [chemical binding]; other site 698972001887 putative Mg++ binding site [ion binding]; other site 698972001888 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 698972001889 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698972001890 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698972001891 Presynaptic Site I dimer interface [polypeptide binding]; other site 698972001892 catalytic residues [active] 698972001893 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698972001894 Synaptic Flat tetramer interface [polypeptide binding]; other site 698972001895 Synaptic Site I dimer interface [polypeptide binding]; other site 698972001896 DNA binding site [nucleotide binding] 698972001897 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 698972001898 active site 698972001899 oxaloacetate decarboxylase; Provisional; Region: PRK12330 698972001900 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698972001901 active site 698972001902 catalytic residues [active] 698972001903 metal binding site [ion binding]; metal-binding site 698972001904 homodimer binding site [polypeptide binding]; other site 698972001905 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 698972001906 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698972001907 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698972001908 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698972001909 carboxyltransferase (CT) interaction site; other site 698972001910 biotinylation site [posttranslational modification]; other site 698972001911 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698972001912 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 698972001913 active site 698972001914 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698972001915 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698972001916 active site 698972001917 peptide chain release factor 2; Validated; Region: prfB; PRK00578 698972001918 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698972001919 RF-1 domain; Region: RF-1; pfam00472 698972001920 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 698972001921 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 698972001922 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698972001923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972001924 Walker A/P-loop; other site 698972001925 ATP binding site [chemical binding]; other site 698972001926 Q-loop/lid; other site 698972001927 ABC transporter signature motif; other site 698972001928 Walker B; other site 698972001929 D-loop; other site 698972001930 H-loop/switch region; other site 698972001931 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 698972001932 FtsX-like permease family; Region: FtsX; pfam02687 698972001933 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 698972001934 SmpB-tmRNA interface; other site 698972001935 Cupin domain; Region: Cupin_2; cl17218 698972001936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698972001937 S-adenosylmethionine binding site [chemical binding]; other site 698972001938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698972001939 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 698972001940 Integrase core domain; Region: rve_3; cl15866 698972001941 Integrase core domain; Region: rve; pfam00665 698972001942 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698972001943 Integrase core domain; Region: rve; pfam00665 698972001944 Protein P3 of Potyviral polyprotein; Region: Potyvirid-P3; pfam13608 698972001945 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698972001946 Helix-turn-helix domain; Region: HTH_38; pfam13936 698972001947 potential frameshift: common BLAST hit: gi|172041139|ref|YP_001800853.1| transposase for insertion sequence 698972001948 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698972001949 Integrase core domain; Region: rve; pfam00665 698972001950 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698972001951 Integrase core domain; Region: rve; pfam00665 698972001952 potential frameshift: common BLAST hit: gi|262201194|ref|YP_003272402.1| class I/II aminotransferase 698972001953 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698972001954 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698972001955 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 698972001956 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698972001957 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698972001958 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698972001959 nucleotide binding region [chemical binding]; other site 698972001960 ATP-binding site [chemical binding]; other site 698972001961 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698972001962 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698972001963 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 698972001964 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698972001965 DNA-binding site [nucleotide binding]; DNA binding site 698972001966 RNA-binding motif; other site 698972001967 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 698972001968 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 698972001969 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 698972001970 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 698972001971 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698972001972 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698972001973 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 698972001974 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698972001975 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698972001976 catalytic residue [active] 698972001977 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 698972001978 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 698972001979 dimer interface [polypeptide binding]; other site 698972001980 active site 698972001981 citrylCoA binding site [chemical binding]; other site 698972001982 NADH binding [chemical binding]; other site 698972001983 cationic pore residues; other site 698972001984 oxalacetate/citrate binding site [chemical binding]; other site 698972001985 coenzyme A binding site [chemical binding]; other site 698972001986 catalytic triad [active] 698972001987 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698972001988 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 698972001989 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698972001990 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698972001991 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698972001992 active site 698972001993 catalytic tetrad [active] 698972001994 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 698972001995 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698972001996 substrate binding site [chemical binding]; other site 698972001997 oxyanion hole (OAH) forming residues; other site 698972001998 trimer interface [polypeptide binding]; other site 698972001999 Protein of unknown function, DUF485; Region: DUF485; pfam04341 698972002000 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698972002001 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 698972002002 Na binding site [ion binding]; other site 698972002003 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 698972002004 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 698972002005 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698972002006 Fic/DOC family; Region: Fic; cl00960 698972002007 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 698972002008 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 698972002009 active site 698972002010 SAM binding site [chemical binding]; other site 698972002011 homodimer interface [polypeptide binding]; other site 698972002012 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698972002013 catalytic residues [active] 698972002014 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 698972002015 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 698972002016 folate binding site [chemical binding]; other site 698972002017 NADP+ binding site [chemical binding]; other site 698972002018 thymidylate synthase; Reviewed; Region: thyA; PRK01827 698972002019 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 698972002020 dimerization interface [polypeptide binding]; other site 698972002021 active site 698972002022 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 698972002023 active site 698972002024 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698972002025 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 698972002026 ATP binding site [chemical binding]; other site 698972002027 putative Mg++ binding site [ion binding]; other site 698972002028 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698972002029 nucleotide binding region [chemical binding]; other site 698972002030 ATP-binding site [chemical binding]; other site 698972002031 DEAD/H associated; Region: DEAD_assoc; pfam08494 698972002032 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 698972002033 active site 698972002034 SUMO-1 interface [polypeptide binding]; other site 698972002035 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698972002036 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 698972002037 putative DNA binding site [nucleotide binding]; other site 698972002038 catalytic residue [active] 698972002039 putative H2TH interface [polypeptide binding]; other site 698972002040 putative catalytic residues [active] 698972002041 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698972002042 Predicted permease [General function prediction only]; Region: COG2985 698972002043 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 698972002044 TrkA-C domain; Region: TrkA_C; pfam02080 698972002045 TrkA-C domain; Region: TrkA_C; pfam02080 698972002046 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 698972002047 hypothetical protein; Provisional; Region: PRK11770 698972002048 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698972002049 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698972002050 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 698972002051 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 698972002052 active site 698972002053 dimer interface [polypeptide binding]; other site 698972002054 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 698972002055 dimer interface [polypeptide binding]; other site 698972002056 active site 698972002057 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698972002058 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698972002059 tetramerization interface [polypeptide binding]; other site 698972002060 NAD(P) binding site [chemical binding]; other site 698972002061 catalytic residues [active] 698972002062 hypothetical protein; Provisional; Region: PRK07857 698972002063 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 698972002064 Part of AAA domain; Region: AAA_19; pfam13245 698972002065 Family description; Region: UvrD_C_2; pfam13538 698972002066 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698972002067 Peptidase family M23; Region: Peptidase_M23; pfam01551 698972002068 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 698972002069 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 698972002070 active site 698972002071 substrate binding site [chemical binding]; other site 698972002072 cosubstrate binding site; other site 698972002073 catalytic site [active] 698972002074 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 698972002075 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 698972002076 purine monophosphate binding site [chemical binding]; other site 698972002077 dimer interface [polypeptide binding]; other site 698972002078 putative catalytic residues [active] 698972002079 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 698972002080 Late expression factor 8 (LEF-8); Region: LEF-8; pfam04941 698972002081 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 698972002082 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698972002083 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 698972002084 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698972002085 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698972002086 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 698972002087 30S ribosomal protein S18; Provisional; Region: PRK13401 698972002088 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 698972002089 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 698972002090 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 698972002091 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 698972002092 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 698972002093 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698972002094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698972002095 active site 698972002096 phosphorylation site [posttranslational modification] 698972002097 intermolecular recognition site; other site 698972002098 dimerization interface [polypeptide binding]; other site 698972002099 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698972002100 DNA binding site [nucleotide binding] 698972002101 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698972002102 dimerization interface [polypeptide binding]; other site 698972002103 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698972002104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698972002105 dimer interface [polypeptide binding]; other site 698972002106 phosphorylation site [posttranslational modification] 698972002107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698972002108 ATP binding site [chemical binding]; other site 698972002109 Mg2+ binding site [ion binding]; other site 698972002110 G-X-G motif; other site 698972002111 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698972002112 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698972002113 protein binding site [polypeptide binding]; other site 698972002114 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698972002115 MPT binding site; other site 698972002116 trimer interface [polypeptide binding]; other site 698972002117 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 698972002118 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 698972002119 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 698972002120 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 698972002121 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 698972002122 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 698972002123 active site 698972002124 tetramer interface; other site 698972002125 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698972002126 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698972002127 dimer interface [polypeptide binding]; other site 698972002128 putative functional site; other site 698972002129 putative MPT binding site; other site 698972002130 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698972002131 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698972002132 Predicted membrane protein [Function unknown]; Region: COG2259 698972002133 Predicted integral membrane protein [Function unknown]; Region: COG5660 698972002134 Putative zinc-finger; Region: zf-HC2; pfam13490 698972002135 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 698972002136 BCCT family transporter; Region: BCCT; pfam02028 698972002137 Uncharacterized membrane protein [Function unknown]; Region: COG3949 698972002138 Predicted methyltransferases [General function prediction only]; Region: COG0313 698972002139 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 698972002140 putative SAM binding site [chemical binding]; other site 698972002141 putative homodimer interface [polypeptide binding]; other site 698972002142 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 698972002143 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 698972002144 active site 698972002145 HIGH motif; other site 698972002146 KMSKS motif; other site 698972002147 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 698972002148 tRNA binding surface [nucleotide binding]; other site 698972002149 anticodon binding site; other site 698972002150 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 698972002151 active site 698972002152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 698972002153 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698972002154 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698972002155 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698972002156 G5 domain; Region: G5; pfam07501 698972002157 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698972002158 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 698972002159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698972002160 S-adenosylmethionine binding site [chemical binding]; other site 698972002161 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 698972002162 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698972002163 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698972002164 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698972002165 ABC transporter; Region: ABC_tran_2; pfam12848 698972002166 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698972002167 Uncharacterized conserved protein [Function unknown]; Region: COG1359 698972002168 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698972002169 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698972002170 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698972002171 DNA binding residues [nucleotide binding] 698972002172 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698972002173 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 698972002174 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698972002175 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698972002176 active site 698972002177 motif I; other site 698972002178 motif II; other site 698972002179 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698972002180 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 698972002181 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698972002182 substrate binding site [chemical binding]; other site 698972002183 oxyanion hole (OAH) forming residues; other site 698972002184 trimer interface [polypeptide binding]; other site 698972002185 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 698972002186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698972002187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698972002188 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 698972002189 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 698972002190 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698972002191 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 698972002192 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 698972002193 G1 box; other site 698972002194 putative GEF interaction site [polypeptide binding]; other site 698972002195 GTP/Mg2+ binding site [chemical binding]; other site 698972002196 Switch I region; other site 698972002197 G2 box; other site 698972002198 G3 box; other site 698972002199 Switch II region; other site 698972002200 G4 box; other site 698972002201 G5 box; other site 698972002202 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 698972002203 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 698972002204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698972002205 NAD(P) binding site [chemical binding]; other site 698972002206 active site 698972002207 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698972002208 putative active site [active] 698972002209 catalytic residue [active] 698972002210 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698972002211 active site 698972002212 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698972002213 putative active site [active] 698972002214 catalytic residue [active] 698972002215 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 698972002216 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 698972002217 5S rRNA interface [nucleotide binding]; other site 698972002218 CTC domain interface [polypeptide binding]; other site 698972002219 L16 interface [polypeptide binding]; other site 698972002220 pullulanase, type I; Region: pulA_typeI; TIGR02104 698972002221 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 698972002222 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 698972002223 Ca binding site [ion binding]; other site 698972002224 active site 698972002225 catalytic site [active] 698972002226 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 698972002227 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 698972002228 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698972002229 active site 698972002230 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 698972002231 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 698972002232 Substrate binding site; other site 698972002233 Mg++ binding site; other site 698972002234 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 698972002235 active site 698972002236 substrate binding site [chemical binding]; other site 698972002237 CoA binding site [chemical binding]; other site 698972002238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698972002239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698972002240 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 698972002241 putative dimerization interface [polypeptide binding]; other site 698972002242 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 698972002243 gating phenylalanine in ion channel; other site 698972002244 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698972002245 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 698972002246 putative ligand binding site [chemical binding]; other site 698972002247 putative NAD binding site [chemical binding]; other site 698972002248 catalytic site [active] 698972002249 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698972002250 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698972002251 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972002252 Q-loop/lid; other site 698972002253 ABC transporter signature motif; other site 698972002254 Walker B; other site 698972002255 D-loop; other site 698972002256 H-loop/switch region; other site 698972002257 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698972002258 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698972002259 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972002260 Walker A/P-loop; other site 698972002261 ATP binding site [chemical binding]; other site 698972002262 Q-loop/lid; other site 698972002263 ABC transporter signature motif; other site 698972002264 Walker B; other site 698972002265 D-loop; other site 698972002266 H-loop/switch region; other site 698972002267 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698972002268 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698972002269 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 698972002270 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 698972002271 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698972002272 ATP binding site [chemical binding]; other site 698972002273 putative Mg++ binding site [ion binding]; other site 698972002274 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698972002275 nucleotide binding region [chemical binding]; other site 698972002276 ATP-binding site [chemical binding]; other site 698972002277 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 698972002278 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 698972002279 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 698972002280 homodimer interface [polypeptide binding]; other site 698972002281 metal binding site [ion binding]; metal-binding site 698972002282 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 698972002283 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698972002284 enolase; Provisional; Region: eno; PRK00077 698972002285 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 698972002286 dimer interface [polypeptide binding]; other site 698972002287 metal binding site [ion binding]; metal-binding site 698972002288 substrate binding pocket [chemical binding]; other site 698972002289 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 698972002290 Septum formation initiator; Region: DivIC; pfam04977 698972002291 Uncharacterized conserved protein [Function unknown]; Region: COG1507 698972002292 exopolyphosphatase; Region: exo_poly_only; TIGR03706 698972002293 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698972002294 Helix-turn-helix domain; Region: HTH_18; pfam12833 698972002295 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698972002296 Bax inhibitor 1 like; Region: BaxI_1; cl17691 698972002297 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 698972002298 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 698972002299 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 698972002300 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 698972002301 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 698972002302 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 698972002303 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698972002304 catalytic residue [active] 698972002305 putative FPP diphosphate binding site; other site 698972002306 putative FPP binding hydrophobic cleft; other site 698972002307 dimer interface [polypeptide binding]; other site 698972002308 putative IPP diphosphate binding site; other site 698972002309 Flavodoxin domain; Region: Flavodoxin_5; cl17428 698972002310 pantothenate kinase; Provisional; Region: PRK05439 698972002311 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 698972002312 ATP-binding site [chemical binding]; other site 698972002313 CoA-binding site [chemical binding]; other site 698972002314 Mg2+-binding site [ion binding]; other site 698972002315 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 698972002316 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 698972002317 dimer interface [polypeptide binding]; other site 698972002318 active site 698972002319 glycine-pyridoxal phosphate binding site [chemical binding]; other site 698972002320 folate binding site [chemical binding]; other site 698972002321 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698972002322 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 698972002323 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698972002324 Coenzyme A binding pocket [chemical binding]; other site 698972002325 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698972002326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972002327 putative substrate translocation pore; other site 698972002328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972002329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698972002330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698972002331 fumarate hydratase; Reviewed; Region: fumC; PRK00485 698972002332 Class II fumarases; Region: Fumarase_classII; cd01362 698972002333 active site 698972002334 tetramer interface [polypeptide binding]; other site 698972002335 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 698972002336 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 698972002337 putative active site [active] 698972002338 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 698972002339 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 698972002340 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 698972002341 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 698972002342 generic binding surface II; other site 698972002343 generic binding surface I; other site 698972002344 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 698972002345 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 698972002346 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698972002347 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698972002348 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 698972002349 Na2 binding site [ion binding]; other site 698972002350 putative substrate binding site 1 [chemical binding]; other site 698972002351 Na binding site 1 [ion binding]; other site 698972002352 putative substrate binding site 2 [chemical binding]; other site 698972002353 GTP-binding protein YchF; Reviewed; Region: PRK09601 698972002354 YchF GTPase; Region: YchF; cd01900 698972002355 G1 box; other site 698972002356 GTP/Mg2+ binding site [chemical binding]; other site 698972002357 Switch I region; other site 698972002358 G2 box; other site 698972002359 Switch II region; other site 698972002360 G3 box; other site 698972002361 G4 box; other site 698972002362 G5 box; other site 698972002363 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 698972002364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 698972002365 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 698972002366 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 698972002367 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 698972002368 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 698972002369 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 698972002370 Cl- selectivity filter; other site 698972002371 Cl- binding residues [ion binding]; other site 698972002372 pore gating glutamate residue; other site 698972002373 dimer interface [polypeptide binding]; other site 698972002374 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698972002375 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698972002376 Walker A/P-loop; other site 698972002377 ATP binding site [chemical binding]; other site 698972002378 Q-loop/lid; other site 698972002379 ABC transporter signature motif; other site 698972002380 Walker B; other site 698972002381 D-loop; other site 698972002382 H-loop/switch region; other site 698972002383 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 698972002384 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698972002385 Walker A/P-loop; other site 698972002386 ATP binding site [chemical binding]; other site 698972002387 Q-loop/lid; other site 698972002388 ABC transporter signature motif; other site 698972002389 Walker B; other site 698972002390 D-loop; other site 698972002391 H-loop/switch region; other site 698972002392 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698972002393 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 698972002394 active site 698972002395 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698972002396 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698972002397 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698972002398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698972002399 dimer interface [polypeptide binding]; other site 698972002400 conserved gate region; other site 698972002401 ABC-ATPase subunit interface; other site 698972002402 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698972002403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698972002404 dimer interface [polypeptide binding]; other site 698972002405 conserved gate region; other site 698972002406 putative PBP binding loops; other site 698972002407 ABC-ATPase subunit interface; other site 698972002408 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698972002409 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698972002410 Walker A/P-loop; other site 698972002411 ATP binding site [chemical binding]; other site 698972002412 Q-loop/lid; other site 698972002413 ABC transporter signature motif; other site 698972002414 Walker B; other site 698972002415 D-loop; other site 698972002416 H-loop/switch region; other site 698972002417 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698972002418 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698972002419 Walker A/P-loop; other site 698972002420 ATP binding site [chemical binding]; other site 698972002421 Q-loop/lid; other site 698972002422 ABC transporter signature motif; other site 698972002423 Walker B; other site 698972002424 D-loop; other site 698972002425 H-loop/switch region; other site 698972002426 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698972002427 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698972002428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972002429 Walker A/P-loop; other site 698972002430 ATP binding site [chemical binding]; other site 698972002431 ABC transporter signature motif; other site 698972002432 Walker B; other site 698972002433 D-loop; other site 698972002434 H-loop/switch region; other site 698972002435 Integrase core domain; Region: rve; pfam00665 698972002436 Integrase core domain; Region: rve_3; cl15866 698972002437 Trypsin; Region: Trypsin; pfam00089 698972002438 active site 698972002439 substrate binding sites [chemical binding]; other site 698972002440 Protein of unknown function (DUF402); Region: DUF402; cl00979 698972002441 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 698972002442 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 698972002443 G1 box; other site 698972002444 GTP/Mg2+ binding site [chemical binding]; other site 698972002445 G2 box; other site 698972002446 Switch I region; other site 698972002447 G3 box; other site 698972002448 Switch II region; other site 698972002449 G4 box; other site 698972002450 G5 box; other site 698972002451 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 698972002452 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 698972002453 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 698972002454 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698972002455 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 698972002456 Ferredoxin [Energy production and conversion]; Region: COG1146 698972002457 4Fe-4S binding domain; Region: Fer4; pfam00037 698972002458 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 698972002459 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698972002460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698972002461 homodimer interface [polypeptide binding]; other site 698972002462 catalytic residue [active] 698972002463 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698972002464 active site 698972002465 Predicted membrane protein [Function unknown]; Region: COG2246 698972002466 GtrA-like protein; Region: GtrA; pfam04138 698972002467 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698972002468 active site 698972002469 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 698972002470 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698972002471 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 698972002472 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 698972002473 putative trimer interface [polypeptide binding]; other site 698972002474 putative CoA binding site [chemical binding]; other site 698972002475 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 698972002476 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 698972002477 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 698972002478 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698972002479 putative trimer interface [polypeptide binding]; other site 698972002480 putative CoA binding site [chemical binding]; other site 698972002481 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 698972002482 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 698972002483 metal binding site [ion binding]; metal-binding site 698972002484 putative dimer interface [polypeptide binding]; other site 698972002485 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698972002486 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698972002487 dihydropteroate synthase; Region: DHPS; TIGR01496 698972002488 substrate binding pocket [chemical binding]; other site 698972002489 dimer interface [polypeptide binding]; other site 698972002490 inhibitor binding site; inhibition site 698972002491 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 698972002492 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 698972002493 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 698972002494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698972002495 S-adenosylmethionine binding site [chemical binding]; other site 698972002496 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 698972002497 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 698972002498 active site 698972002499 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 698972002500 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 698972002501 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 698972002502 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698972002503 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 698972002504 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 698972002505 ligand binding site; other site 698972002506 oligomer interface; other site 698972002507 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 698972002508 dimer interface [polypeptide binding]; other site 698972002509 N-terminal domain interface [polypeptide binding]; other site 698972002510 sulfate 1 binding site; other site 698972002511 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 698972002512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698972002513 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 698972002514 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698972002515 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698972002516 DNA binding residues [nucleotide binding] 698972002517 Putative zinc-finger; Region: zf-HC2; pfam13490 698972002518 sec-independent translocase; Provisional; Region: tatB; PRK00182 698972002519 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 698972002520 Domain of unknown function DUF59; Region: DUF59; pfam01883 698972002521 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 698972002522 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 698972002523 Predicted membrane protein [Function unknown]; Region: COG4420 698972002524 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 698972002525 MgtE intracellular N domain; Region: MgtE_N; smart00924 698972002526 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 698972002527 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 698972002528 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698972002529 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 698972002530 TPP-binding site [chemical binding]; other site 698972002531 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 698972002532 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698972002533 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698972002534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972002535 Walker A/P-loop; other site 698972002536 ATP binding site [chemical binding]; other site 698972002537 Q-loop/lid; other site 698972002538 ABC transporter signature motif; other site 698972002539 Walker B; other site 698972002540 D-loop; other site 698972002541 H-loop/switch region; other site 698972002542 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698972002543 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698972002544 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972002545 Walker A/P-loop; other site 698972002546 ATP binding site [chemical binding]; other site 698972002547 Q-loop/lid; other site 698972002548 ABC transporter signature motif; other site 698972002549 Walker B; other site 698972002550 D-loop; other site 698972002551 H-loop/switch region; other site 698972002552 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 698972002553 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698972002554 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698972002555 shikimate binding site; other site 698972002556 NAD(P) binding site [chemical binding]; other site 698972002557 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698972002558 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698972002559 substrate binding pocket [chemical binding]; other site 698972002560 catalytic triad [active] 698972002561 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 698972002562 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 698972002563 active site 698972002564 catalytic residues [active] 698972002565 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698972002566 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 698972002567 Na binding site [ion binding]; other site 698972002568 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698972002569 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 698972002570 nucleotide binding site/active site [active] 698972002571 HIT family signature motif; other site 698972002572 catalytic residue [active] 698972002573 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 698972002574 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698972002575 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698972002576 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698972002577 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 698972002578 PLD-like domain; Region: PLDc_2; pfam13091 698972002579 putative homodimer interface [polypeptide binding]; other site 698972002580 putative active site [active] 698972002581 catalytic site [active] 698972002582 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698972002583 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698972002584 putative Mg++ binding site [ion binding]; other site 698972002585 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698972002586 nucleotide binding region [chemical binding]; other site 698972002587 ATP-binding site [chemical binding]; other site 698972002588 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 698972002589 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 698972002590 active site 698972002591 8-oxo-dGMP binding site [chemical binding]; other site 698972002592 nudix motif; other site 698972002593 metal binding site [ion binding]; metal-binding site 698972002594 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 698972002595 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698972002596 ATP binding site [chemical binding]; other site 698972002597 Mg++ binding site [ion binding]; other site 698972002598 motif III; other site 698972002599 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698972002600 nucleotide binding region [chemical binding]; other site 698972002601 ATP-binding site [chemical binding]; other site 698972002602 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 698972002603 putative RNA binding site [nucleotide binding]; other site 698972002604 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698972002605 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698972002606 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 698972002607 Na binding site [ion binding]; other site 698972002608 SNF2 Helicase protein; Region: DUF3670; pfam12419 698972002609 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 698972002610 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698972002611 ATP binding site [chemical binding]; other site 698972002612 putative Mg++ binding site [ion binding]; other site 698972002613 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698972002614 nucleotide binding region [chemical binding]; other site 698972002615 ATP-binding site [chemical binding]; other site 698972002616 Uncharacterized conserved protein [Function unknown]; Region: COG4279 698972002617 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 698972002618 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 698972002619 active site 698972002620 metal binding site [ion binding]; metal-binding site 698972002621 DNA binding site [nucleotide binding] 698972002622 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 698972002623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972002624 Walker A/P-loop; other site 698972002625 ATP binding site [chemical binding]; other site 698972002626 Q-loop/lid; other site 698972002627 Uncharacterized conserved protein [Function unknown]; Region: COG2353 698972002628 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698972002629 MarR family; Region: MarR_2; pfam12802 698972002630 PspC domain; Region: PspC; cl00864 698972002631 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698972002632 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 698972002633 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 698972002634 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 698972002635 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698972002636 Cysteine-rich domain; Region: CCG; pfam02754 698972002637 Cysteine-rich domain; Region: CCG; pfam02754 698972002638 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698972002639 L-lactate permease; Region: Lactate_perm; cl00701 698972002640 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 698972002641 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 698972002642 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 698972002643 active site 698972002644 HIGH motif; other site 698972002645 KMSK motif region; other site 698972002646 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 698972002647 tRNA binding surface [nucleotide binding]; other site 698972002648 anticodon binding site; other site 698972002649 diaminopimelate decarboxylase; Region: lysA; TIGR01048 698972002650 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 698972002651 active site 698972002652 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698972002653 substrate binding site [chemical binding]; other site 698972002654 catalytic residues [active] 698972002655 dimer interface [polypeptide binding]; other site 698972002656 homoserine dehydrogenase; Provisional; Region: PRK06349 698972002657 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 698972002658 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 698972002659 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 698972002660 homoserine kinase; Provisional; Region: PRK01212 698972002661 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 698972002662 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698972002663 acyl-activating enzyme (AAE) consensus motif; other site 698972002664 AMP binding site [chemical binding]; other site 698972002665 active site 698972002666 CoA binding site [chemical binding]; other site 698972002667 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 698972002668 transcription termination factor Rho; Provisional; Region: PRK12608 698972002669 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698972002670 RNA binding site [nucleotide binding]; other site 698972002671 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 698972002672 multimer interface [polypeptide binding]; other site 698972002673 Walker A motif; other site 698972002674 ATP binding site [chemical binding]; other site 698972002675 Walker B motif; other site 698972002676 peptide chain release factor 1; Validated; Region: prfA; PRK00591 698972002677 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698972002678 RF-1 domain; Region: RF-1; pfam00472 698972002679 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 698972002680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698972002681 S-adenosylmethionine binding site [chemical binding]; other site 698972002682 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 698972002683 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 698972002684 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 698972002685 Mg++ binding site [ion binding]; other site 698972002686 putative catalytic motif [active] 698972002687 substrate binding site [chemical binding]; other site 698972002688 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 698972002689 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 698972002690 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 698972002691 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 698972002692 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 698972002693 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 698972002694 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 698972002695 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 698972002696 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698972002697 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 698972002698 beta subunit interaction interface [polypeptide binding]; other site 698972002699 Walker A motif; other site 698972002700 ATP binding site [chemical binding]; other site 698972002701 Walker B motif; other site 698972002702 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698972002703 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 698972002704 core domain interface [polypeptide binding]; other site 698972002705 delta subunit interface [polypeptide binding]; other site 698972002706 epsilon subunit interface [polypeptide binding]; other site 698972002707 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 698972002708 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698972002709 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 698972002710 alpha subunit interaction interface [polypeptide binding]; other site 698972002711 Walker A motif; other site 698972002712 ATP binding site [chemical binding]; other site 698972002713 Walker B motif; other site 698972002714 inhibitor binding site; inhibition site 698972002715 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698972002716 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 698972002717 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 698972002718 gamma subunit interface [polypeptide binding]; other site 698972002719 epsilon subunit interface [polypeptide binding]; other site 698972002720 LBP interface [polypeptide binding]; other site 698972002721 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 698972002722 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 698972002723 hypothetical protein; Provisional; Region: PRK03298 698972002724 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 698972002725 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698972002726 dimer interface [polypeptide binding]; other site 698972002727 substrate binding site [chemical binding]; other site 698972002728 metal binding site [ion binding]; metal-binding site 698972002729 Domain of unknown function DUF77; Region: DUF77; pfam01910 698972002730 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698972002731 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698972002732 Walker A/P-loop; other site 698972002733 ATP binding site [chemical binding]; other site 698972002734 Q-loop/lid; other site 698972002735 ABC transporter signature motif; other site 698972002736 Walker B; other site 698972002737 D-loop; other site 698972002738 H-loop/switch region; other site 698972002739 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698972002740 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698972002741 ABC-ATPase subunit interface; other site 698972002742 dimer interface [polypeptide binding]; other site 698972002743 putative PBP binding regions; other site 698972002744 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698972002745 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698972002746 ABC-ATPase subunit interface; other site 698972002747 dimer interface [polypeptide binding]; other site 698972002748 putative PBP binding regions; other site 698972002749 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 698972002750 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698972002751 siderophore binding site; other site 698972002752 TIGR02611 family protein; Region: TIGR02611 698972002753 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 698972002754 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 698972002755 glycogen branching enzyme; Provisional; Region: PRK05402 698972002756 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 698972002757 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 698972002758 active site 698972002759 catalytic site [active] 698972002760 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 698972002761 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 698972002762 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 698972002763 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698972002764 active site 698972002765 homodimer interface [polypeptide binding]; other site 698972002766 catalytic site [active] 698972002767 acceptor binding site [chemical binding]; other site 698972002768 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698972002769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972002770 Walker A/P-loop; other site 698972002771 ATP binding site [chemical binding]; other site 698972002772 Q-loop/lid; other site 698972002773 ABC transporter signature motif; other site 698972002774 Walker B; other site 698972002775 D-loop; other site 698972002776 H-loop/switch region; other site 698972002777 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 698972002778 Ligand binding site [chemical binding]; other site 698972002779 Electron transfer flavoprotein domain; Region: ETF; pfam01012 698972002780 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 698972002781 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 698972002782 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 698972002783 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 698972002784 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 698972002785 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698972002786 catalytic residue [active] 698972002787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698972002788 S-adenosylmethionine binding site [chemical binding]; other site 698972002789 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 698972002790 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 698972002791 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698972002792 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698972002793 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698972002794 active site 698972002795 catalytic site [active] 698972002796 substrate binding site [chemical binding]; other site 698972002797 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 698972002798 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 698972002799 nucleotide binding pocket [chemical binding]; other site 698972002800 K-X-D-G motif; other site 698972002801 catalytic site [active] 698972002802 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 698972002803 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 698972002804 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 698972002805 Dimer interface [polypeptide binding]; other site 698972002806 BRCT sequence motif; other site 698972002807 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698972002808 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 698972002809 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698972002810 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 698972002811 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 698972002812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698972002813 Coenzyme A binding pocket [chemical binding]; other site 698972002814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972002815 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698972002816 putative substrate translocation pore; other site 698972002817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972002818 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698972002819 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698972002820 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698972002821 ABC-ATPase subunit interface; other site 698972002822 dimer interface [polypeptide binding]; other site 698972002823 putative PBP binding regions; other site 698972002824 proposed F420-0 ABC transporter, ATP-binding protein; Region: F420-0_ABC_ATP; TIGR03873 698972002825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972002826 Walker A/P-loop; other site 698972002827 ATP binding site [chemical binding]; other site 698972002828 Q-loop/lid; other site 698972002829 ABC transporter signature motif; other site 698972002830 Walker B; other site 698972002831 D-loop; other site 698972002832 H-loop/switch region; other site 698972002833 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 698972002834 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 698972002835 putative ligand binding residues [chemical binding]; other site 698972002836 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 698972002837 phosphofructokinase; Region: PFK_mixed; TIGR02483 698972002838 active site 698972002839 ADP/pyrophosphate binding site [chemical binding]; other site 698972002840 dimerization interface [polypeptide binding]; other site 698972002841 allosteric effector site; other site 698972002842 fructose-1,6-bisphosphate binding site; other site 698972002843 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 698972002844 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 698972002845 GatB domain; Region: GatB_Yqey; smart00845 698972002846 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698972002847 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698972002848 active site 698972002849 catalytic tetrad [active] 698972002850 Lysine efflux permease [General function prediction only]; Region: COG1279 698972002851 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 698972002852 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698972002853 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698972002854 dimerization interface [polypeptide binding]; other site 698972002855 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 698972002856 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 698972002857 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 698972002858 putative dimer interface [polypeptide binding]; other site 698972002859 N-terminal domain interface [polypeptide binding]; other site 698972002860 putative substrate binding pocket (H-site) [chemical binding]; other site 698972002861 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 698972002862 Predicted membrane protein [Function unknown]; Region: COG2259 698972002863 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 698972002864 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698972002865 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 698972002866 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698972002867 PYR/PP interface [polypeptide binding]; other site 698972002868 dimer interface [polypeptide binding]; other site 698972002869 TPP binding site [chemical binding]; other site 698972002870 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698972002871 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 698972002872 TPP-binding site [chemical binding]; other site 698972002873 dimer interface [polypeptide binding]; other site 698972002874 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 698972002875 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 698972002876 putative valine binding site [chemical binding]; other site 698972002877 dimer interface [polypeptide binding]; other site 698972002878 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 698972002879 ketol-acid reductoisomerase; Provisional; Region: PRK05479 698972002880 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 698972002881 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 698972002882 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 698972002883 Uncharacterized conserved protein [Function unknown]; Region: COG1479 698972002884 Protein of unknown function DUF262; Region: DUF262; pfam03235 698972002885 Uncharacterized conserved protein [Function unknown]; Region: COG3472 698972002886 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 698972002887 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 698972002888 ligand binding site [chemical binding]; other site 698972002889 NAD binding site [chemical binding]; other site 698972002890 dimerization interface [polypeptide binding]; other site 698972002891 catalytic site [active] 698972002892 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 698972002893 putative L-serine binding site [chemical binding]; other site 698972002894 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 698972002895 tartrate dehydrogenase; Region: TTC; TIGR02089 698972002896 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 698972002897 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 698972002898 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698972002899 catalytic site [active] 698972002900 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 698972002901 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 698972002902 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 698972002903 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698972002904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698972002905 S-adenosylmethionine binding site [chemical binding]; other site 698972002906 isochorismate synthase DhbC; Validated; Region: PRK06923 698972002907 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698972002908 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 698972002909 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698972002910 active site 698972002911 HIGH motif; other site 698972002912 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698972002913 active site 698972002914 KMSKS motif; other site 698972002915 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 698972002916 MMPL family; Region: MMPL; pfam03176 698972002917 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 698972002918 MMPL family; Region: MMPL; pfam03176 698972002919 Cutinase; Region: Cutinase; pfam01083 698972002920 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 698972002921 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 698972002922 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 698972002923 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 698972002924 PhnA protein; Region: PhnA; pfam03831 698972002925 biotin synthase; Region: bioB; TIGR00433 698972002926 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698972002927 FeS/SAM binding site; other site 698972002928 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698972002929 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698972002930 HD domain; Region: HD_4; pfam13328 698972002931 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698972002932 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698972002933 putative DNA binding site [nucleotide binding]; other site 698972002934 putative Zn2+ binding site [ion binding]; other site 698972002935 Bacterial transcriptional regulator; Region: IclR; pfam01614 698972002936 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 698972002937 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 698972002938 substrate binding site [chemical binding]; other site 698972002939 ligand binding site [chemical binding]; other site 698972002940 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 698972002941 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 698972002942 substrate binding site [chemical binding]; other site 698972002943 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698972002944 active site 698972002945 Ap6A binding site [chemical binding]; other site 698972002946 nudix motif; other site 698972002947 metal binding site [ion binding]; metal-binding site 698972002948 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698972002949 catalytic core [active] 698972002950 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 698972002951 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698972002952 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 698972002953 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 698972002954 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 698972002955 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698972002956 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698972002957 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698972002958 thiamine monophosphate kinase; Provisional; Region: PRK05731 698972002959 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 698972002960 ATP binding site [chemical binding]; other site 698972002961 dimerization interface [polypeptide binding]; other site 698972002962 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 698972002963 ligand binding site [chemical binding]; other site 698972002964 active site 698972002965 UGI interface [polypeptide binding]; other site 698972002966 catalytic site [active] 698972002967 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 698972002968 DAK2 domain; Region: Dak2; pfam02734 698972002969 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 698972002970 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 698972002971 generic binding surface II; other site 698972002972 ssDNA binding site; other site 698972002973 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698972002974 ATP binding site [chemical binding]; other site 698972002975 putative Mg++ binding site [ion binding]; other site 698972002976 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698972002977 nucleotide binding region [chemical binding]; other site 698972002978 ATP-binding site [chemical binding]; other site 698972002979 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 698972002980 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698972002981 carboxyltransferase (CT) interaction site; other site 698972002982 biotinylation site [posttranslational modification]; other site 698972002983 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 698972002984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698972002985 S-adenosylmethionine binding site [chemical binding]; other site 698972002986 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 698972002987 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 698972002988 active site 698972002989 (T/H)XGH motif; other site 698972002990 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698972002991 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698972002992 Walker A/P-loop; other site 698972002993 ATP binding site [chemical binding]; other site 698972002994 Q-loop/lid; other site 698972002995 ABC transporter signature motif; other site 698972002996 Walker B; other site 698972002997 D-loop; other site 698972002998 H-loop/switch region; other site 698972002999 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698972003000 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698972003001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698972003002 dimer interface [polypeptide binding]; other site 698972003003 conserved gate region; other site 698972003004 putative PBP binding loops; other site 698972003005 ABC-ATPase subunit interface; other site 698972003006 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698972003007 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698972003008 substrate binding pocket [chemical binding]; other site 698972003009 membrane-bound complex binding site; other site 698972003010 hinge residues; other site 698972003011 Domain of unknown function (DUF368); Region: DUF368; pfam04018 698972003012 Abi-like protein; Region: Abi_2; pfam07751 698972003013 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 698972003014 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698972003015 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698972003016 ATP binding site [chemical binding]; other site 698972003017 putative Mg++ binding site [ion binding]; other site 698972003018 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698972003019 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 698972003020 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698972003021 HsdM N-terminal domain; Region: HsdM_N; pfam12161 698972003022 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 698972003023 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698972003024 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698972003025 active site 698972003026 Int/Topo IB signature motif; other site 698972003027 catalytic residues [active] 698972003028 DNA binding site [nucleotide binding] 698972003029 DNA polymerase I; Provisional; Region: PRK05755 698972003030 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 698972003031 active site 698972003032 metal binding site 1 [ion binding]; metal-binding site 698972003033 putative 5' ssDNA interaction site; other site 698972003034 metal binding site 3; metal-binding site 698972003035 metal binding site 2 [ion binding]; metal-binding site 698972003036 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 698972003037 putative DNA binding site [nucleotide binding]; other site 698972003038 putative metal binding site [ion binding]; other site 698972003039 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 698972003040 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 698972003041 active site 698972003042 DNA binding site [nucleotide binding] 698972003043 catalytic site [active] 698972003044 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698972003045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698972003046 S-adenosylmethionine binding site [chemical binding]; other site 698972003047 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 698972003048 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 698972003049 RNA binding site [nucleotide binding]; other site 698972003050 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 698972003051 RNA binding site [nucleotide binding]; other site 698972003052 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698972003053 RNA binding site [nucleotide binding]; other site 698972003054 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 698972003055 RNA binding site [nucleotide binding]; other site 698972003056 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 698972003057 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 698972003058 transcriptional antiterminator BglG; Provisional; Region: PRK09772 698972003059 CAT RNA binding domain; Region: CAT_RBD; smart01061 698972003060 PRD domain; Region: PRD; pfam00874 698972003061 PRD domain; Region: PRD; pfam00874 698972003062 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 698972003063 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698972003064 active site turn [active] 698972003065 phosphorylation site [posttranslational modification] 698972003066 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698972003067 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 698972003068 HPr interaction site; other site 698972003069 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698972003070 active site 698972003071 phosphorylation site [posttranslational modification] 698972003072 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 698972003073 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 698972003074 CoA-binding site [chemical binding]; other site 698972003075 ATP-binding [chemical binding]; other site 698972003076 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 698972003077 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698972003078 FeS/SAM binding site; other site 698972003079 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 698972003080 excinuclease ABC subunit B; Provisional; Region: PRK05298 698972003081 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698972003082 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698972003083 nucleotide binding region [chemical binding]; other site 698972003084 ATP-binding site [chemical binding]; other site 698972003085 Ultra-violet resistance protein B; Region: UvrB; pfam12344 698972003086 UvrB/uvrC motif; Region: UVR; pfam02151 698972003087 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698972003088 Ligand Binding Site [chemical binding]; other site 698972003089 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 698972003090 Part of AAA domain; Region: AAA_19; pfam13245 698972003091 PhoH-like protein; Region: PhoH; cl17668 698972003092 Family description; Region: UvrD_C_2; pfam13538 698972003093 Predicted membrane protein [Function unknown]; Region: COG2259 698972003094 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698972003095 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 698972003096 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698972003097 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698972003098 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 698972003099 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 698972003100 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 698972003101 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 698972003102 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 698972003103 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 698972003104 23S rRNA binding site [nucleotide binding]; other site 698972003105 L21 binding site [polypeptide binding]; other site 698972003106 L13 binding site [polypeptide binding]; other site 698972003107 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698972003108 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 698972003109 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698972003110 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 698972003111 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 698972003112 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 698972003113 dimer interface [polypeptide binding]; other site 698972003114 motif 1; other site 698972003115 active site 698972003116 motif 2; other site 698972003117 motif 3; other site 698972003118 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 698972003119 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 698972003120 putative tRNA-binding site [nucleotide binding]; other site 698972003121 B3/4 domain; Region: B3_4; pfam03483 698972003122 tRNA synthetase B5 domain; Region: B5; smart00874 698972003123 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 698972003124 dimer interface [polypeptide binding]; other site 698972003125 motif 1; other site 698972003126 motif 3; other site 698972003127 motif 2; other site 698972003128 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 698972003129 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 698972003130 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698972003131 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 698972003132 heterotetramer interface [polypeptide binding]; other site 698972003133 active site pocket [active] 698972003134 cleavage site 698972003135 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 698972003136 feedback inhibition sensing region; other site 698972003137 homohexameric interface [polypeptide binding]; other site 698972003138 nucleotide binding site [chemical binding]; other site 698972003139 N-acetyl-L-glutamate binding site [chemical binding]; other site 698972003140 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 698972003141 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698972003142 inhibitor-cofactor binding pocket; inhibition site 698972003143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698972003144 catalytic residue [active] 698972003145 ornithine carbamoyltransferase; Provisional; Region: PRK00779 698972003146 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698972003147 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698972003148 arginine repressor; Provisional; Region: PRK03341 698972003149 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 698972003150 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 698972003151 argininosuccinate synthase; Provisional; Region: PRK13820 698972003152 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 698972003153 ANP binding site [chemical binding]; other site 698972003154 Substrate Binding Site II [chemical binding]; other site 698972003155 Substrate Binding Site I [chemical binding]; other site 698972003156 argininosuccinate lyase; Provisional; Region: PRK00855 698972003157 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 698972003158 active sites [active] 698972003159 tetramer interface [polypeptide binding]; other site 698972003160 Uncharacterized conserved protein [Function unknown]; Region: COG2835 698972003161 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 698972003162 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 698972003163 active site 698972003164 HIGH motif; other site 698972003165 dimer interface [polypeptide binding]; other site 698972003166 KMSKS motif; other site 698972003167 Transposase; Region: HTH_Tnp_1; cl17663 698972003168 HTH-like domain; Region: HTH_21; pfam13276 698972003169 Integrase core domain; Region: rve; pfam00665 698972003170 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698972003171 Helix-turn-helix domain; Region: HTH_38; pfam13936 698972003172 Integrase core domain; Region: rve; pfam00665 698972003173 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698972003174 Integrase core domain; Region: rve; pfam00665 698972003175 Protein P3 of Potyviral polyprotein; Region: Potyvirid-P3; pfam13608 698972003176 Integrase core domain; Region: rve_3; pfam13683 698972003177 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698972003178 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698972003179 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 698972003180 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698972003181 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972003182 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 698972003183 Walker A/P-loop; other site 698972003184 ATP binding site [chemical binding]; other site 698972003185 Q-loop/lid; other site 698972003186 ABC transporter signature motif; other site 698972003187 Walker B; other site 698972003188 D-loop; other site 698972003189 H-loop/switch region; other site 698972003190 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 698972003191 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 698972003192 active site 698972003193 substrate binding site [chemical binding]; other site 698972003194 trimer interface [polypeptide binding]; other site 698972003195 CoA binding site [chemical binding]; other site 698972003196 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 698972003197 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 698972003198 homodimer interface [polypeptide binding]; other site 698972003199 active site 698972003200 TDP-binding site; other site 698972003201 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 698972003202 Anticodon binding domain of tRNAs; Region: HGTP_anticodon2; pfam12745 698972003203 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698972003204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972003205 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698972003206 Walker A/P-loop; other site 698972003207 ATP binding site [chemical binding]; other site 698972003208 Q-loop/lid; other site 698972003209 ABC transporter signature motif; other site 698972003210 Walker B; other site 698972003211 D-loop; other site 698972003212 H-loop/switch region; other site 698972003213 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698972003214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972003215 Walker A/P-loop; other site 698972003216 ATP binding site [chemical binding]; other site 698972003217 Q-loop/lid; other site 698972003218 ABC transporter signature motif; other site 698972003219 Walker B; other site 698972003220 D-loop; other site 698972003221 H-loop/switch region; other site 698972003222 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698972003223 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698972003224 Walker A/P-loop; other site 698972003225 ATP binding site [chemical binding]; other site 698972003226 Q-loop/lid; other site 698972003227 ABC transporter signature motif; other site 698972003228 Walker B; other site 698972003229 D-loop; other site 698972003230 H-loop/switch region; other site 698972003231 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698972003232 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972003233 Walker A/P-loop; other site 698972003234 ATP binding site [chemical binding]; other site 698972003235 Q-loop/lid; other site 698972003236 ABC transporter signature motif; other site 698972003237 Walker B; other site 698972003238 D-loop; other site 698972003239 H-loop/switch region; other site 698972003240 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698972003241 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 698972003242 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698972003243 Condensation domain; Region: Condensation; pfam00668 698972003244 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698972003245 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698972003246 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 698972003247 acyl-activating enzyme (AAE) consensus motif; other site 698972003248 AMP binding site [chemical binding]; other site 698972003249 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698972003250 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698972003251 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698972003252 Condensation domain; Region: Condensation; pfam00668 698972003253 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698972003254 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698972003255 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 698972003256 acyl-activating enzyme (AAE) consensus motif; other site 698972003257 AMP binding site [chemical binding]; other site 698972003258 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698972003259 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698972003260 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 698972003261 acyl-activating enzyme (AAE) consensus motif; other site 698972003262 AMP binding site [chemical binding]; other site 698972003263 active site 698972003264 CoA binding site [chemical binding]; other site 698972003265 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 698972003266 Condensation domain; Region: Condensation; pfam00668 698972003267 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698972003268 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698972003269 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 698972003270 acyl-activating enzyme (AAE) consensus motif; other site 698972003271 AMP binding site [chemical binding]; other site 698972003272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698972003273 S-adenosylmethionine binding site [chemical binding]; other site 698972003274 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698972003275 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698972003276 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698972003277 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 698972003278 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698972003279 NADH(P)-binding; Region: NAD_binding_10; pfam13460 698972003280 NAD(P) binding site [chemical binding]; other site 698972003281 transcription termination factor Rho; Provisional; Region: PRK12678 698972003282 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698972003283 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698972003284 active site 698972003285 motif I; other site 698972003286 motif II; other site 698972003287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698972003288 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 698972003289 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698972003290 RNA binding surface [nucleotide binding]; other site 698972003291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698972003292 S-adenosylmethionine binding site [chemical binding]; other site 698972003293 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 698972003294 ATP-NAD kinase; Region: NAD_kinase; pfam01513 698972003295 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 698972003296 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698972003297 Walker A/P-loop; other site 698972003298 ATP binding site [chemical binding]; other site 698972003299 Q-loop/lid; other site 698972003300 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698972003301 ABC transporter signature motif; other site 698972003302 Walker B; other site 698972003303 D-loop; other site 698972003304 H-loop/switch region; other site 698972003305 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 698972003306 Thiamine pyrophosphokinase; Region: TPK; cl08415 698972003307 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 698972003308 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 698972003309 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 698972003310 dimer interface [polypeptide binding]; other site 698972003311 ADP-ribose binding site [chemical binding]; other site 698972003312 active site 698972003313 nudix motif; other site 698972003314 metal binding site [ion binding]; metal-binding site 698972003315 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 698972003316 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 698972003317 active site 698972003318 Int/Topo IB signature motif; other site 698972003319 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698972003320 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698972003321 P-loop; other site 698972003322 Magnesium ion binding site [ion binding]; other site 698972003323 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698972003324 Magnesium ion binding site [ion binding]; other site 698972003325 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 698972003326 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698972003327 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 698972003328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972003329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972003330 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 698972003331 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698972003332 inhibitor-cofactor binding pocket; inhibition site 698972003333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698972003334 catalytic residue [active] 698972003335 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 698972003336 AAA domain; Region: AAA_26; pfam13500 698972003337 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 698972003338 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 698972003339 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698972003340 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698972003341 RNA binding surface [nucleotide binding]; other site 698972003342 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 698972003343 active site 698972003344 cytidylate kinase; Provisional; Region: cmk; PRK00023 698972003345 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 698972003346 CMP-binding site; other site 698972003347 The sites determining sugar specificity; other site 698972003348 GTP-binding protein Der; Reviewed; Region: PRK03003 698972003349 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 698972003350 G1 box; other site 698972003351 GTP/Mg2+ binding site [chemical binding]; other site 698972003352 Switch I region; other site 698972003353 G2 box; other site 698972003354 Switch II region; other site 698972003355 G3 box; other site 698972003356 G4 box; other site 698972003357 G5 box; other site 698972003358 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 698972003359 G1 box; other site 698972003360 GTP/Mg2+ binding site [chemical binding]; other site 698972003361 Switch I region; other site 698972003362 G2 box; other site 698972003363 G3 box; other site 698972003364 Switch II region; other site 698972003365 G4 box; other site 698972003366 G5 box; other site 698972003367 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698972003368 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 698972003369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698972003370 S-adenosylmethionine binding site [chemical binding]; other site 698972003371 Putative esterase; Region: Esterase; pfam00756 698972003372 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698972003373 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 698972003374 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698972003375 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 698972003376 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698972003377 nucleotide binding region [chemical binding]; other site 698972003378 ATP-binding site [chemical binding]; other site 698972003379 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 698972003380 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698972003381 phosphopeptide binding site; other site 698972003382 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 698972003383 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698972003384 DNA binding residues [nucleotide binding] 698972003385 Bifunctional nuclease; Region: DNase-RNase; pfam02577 698972003386 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 698972003387 DNA binding residues [nucleotide binding] 698972003388 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698972003389 putative dimer interface [polypeptide binding]; other site 698972003390 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698972003391 metal ion-dependent adhesion site (MIDAS); other site 698972003392 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698972003393 Domain of unknown function DUF21; Region: DUF21; pfam01595 698972003394 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698972003395 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698972003396 Domain of unknown function DUF21; Region: DUF21; pfam01595 698972003397 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698972003398 Transporter associated domain; Region: CorC_HlyC; smart01091 698972003399 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 698972003400 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698972003401 ATP binding site [chemical binding]; other site 698972003402 Mg++ binding site [ion binding]; other site 698972003403 motif III; other site 698972003404 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698972003405 nucleotide binding region [chemical binding]; other site 698972003406 ATP-binding site [chemical binding]; other site 698972003407 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698972003408 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 698972003409 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 698972003410 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 698972003411 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 698972003412 CoenzymeA binding site [chemical binding]; other site 698972003413 subunit interaction site [polypeptide binding]; other site 698972003414 PHB binding site; other site 698972003415 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 698972003416 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 698972003417 oligomer interface [polypeptide binding]; other site 698972003418 metal binding site [ion binding]; metal-binding site 698972003419 metal binding site [ion binding]; metal-binding site 698972003420 putative Cl binding site [ion binding]; other site 698972003421 basic sphincter; other site 698972003422 hydrophobic gate; other site 698972003423 periplasmic entrance; other site 698972003424 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698972003425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698972003426 S-adenosylmethionine binding site [chemical binding]; other site 698972003427 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698972003428 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698972003429 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698972003430 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 698972003431 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698972003432 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 698972003433 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698972003434 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 698972003435 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698972003436 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698972003437 FAD binding domain; Region: FAD_binding_4; pfam01565 698972003438 potential frameshift: common BLAST hit: gi|38233809|ref|NP_939576.1| sodium-dependent transport membrane protein 698972003439 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698972003440 Sodium Bile acid symporter family; Region: SBF; cl17470 698972003441 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698972003442 YceI-like domain; Region: YceI; pfam04264 698972003443 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 698972003444 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 698972003445 Ligand binding site; other site 698972003446 Putative Catalytic site; other site 698972003447 DXD motif; other site 698972003448 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 698972003449 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 698972003450 putative active site [active] 698972003451 catalytic triad [active] 698972003452 putative dimer interface [polypeptide binding]; other site 698972003453 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 698972003454 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 698972003455 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698972003456 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698972003457 precorrin-3B synthase; Region: CobG; TIGR02435 698972003458 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698972003459 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698972003460 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 698972003461 Precorrin-8X methylmutase; Region: CbiC; pfam02570 698972003462 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 698972003463 active site 698972003464 SAM binding site [chemical binding]; other site 698972003465 homodimer interface [polypeptide binding]; other site 698972003466 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 698972003467 active site 698972003468 SAM binding site [chemical binding]; other site 698972003469 homodimer interface [polypeptide binding]; other site 698972003470 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 698972003471 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 698972003472 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 698972003473 active site 698972003474 SAM binding site [chemical binding]; other site 698972003475 homodimer interface [polypeptide binding]; other site 698972003476 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 698972003477 active site 698972003478 putative homodimer interface [polypeptide binding]; other site 698972003479 SAM binding site [chemical binding]; other site 698972003480 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 698972003481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698972003482 S-adenosylmethionine binding site [chemical binding]; other site 698972003483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698972003484 short chain dehydrogenase; Provisional; Region: PRK08251 698972003485 NAD(P) binding site [chemical binding]; other site 698972003486 active site 698972003487 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698972003488 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698972003489 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698972003490 active site 698972003491 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698972003492 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698972003493 ATP binding site [chemical binding]; other site 698972003494 putative Mg++ binding site [ion binding]; other site 698972003495 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698972003496 nucleotide binding region [chemical binding]; other site 698972003497 ATP-binding site [chemical binding]; other site 698972003498 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 698972003499 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 698972003500 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 698972003501 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 698972003502 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 698972003503 Predicted transcriptional regulator [Transcription]; Region: COG2378 698972003504 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 698972003505 WYL domain; Region: WYL; pfam13280 698972003506 WYL domain; Region: WYL; pfam13280 698972003507 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 698972003508 Pup-like protein; Region: Pup; pfam05639 698972003509 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 698972003510 proteasome ATPase; Region: pup_AAA; TIGR03689 698972003511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698972003512 Walker A motif; other site 698972003513 ATP binding site [chemical binding]; other site 698972003514 Walker B motif; other site 698972003515 arginine finger; other site 698972003516 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 698972003517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698972003518 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 698972003519 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 698972003520 active site 698972003521 metal binding site [ion binding]; metal-binding site 698972003522 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 698972003523 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 698972003524 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 698972003525 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 698972003526 Potassium binding sites [ion binding]; other site 698972003527 Cesium cation binding sites [ion binding]; other site 698972003528 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 698972003529 Aspartase; Region: Aspartase; cd01357 698972003530 active sites [active] 698972003531 tetramer interface [polypeptide binding]; other site 698972003532 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698972003533 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 698972003534 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 698972003535 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 698972003536 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 698972003537 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 698972003538 homodimer interface [polypeptide binding]; other site 698972003539 putative metal binding site [ion binding]; other site 698972003540 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 698972003541 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698972003542 motif II; other site 698972003543 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 698972003544 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 698972003545 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 698972003546 substrate binding pocket [chemical binding]; other site 698972003547 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 698972003548 B12 binding site [chemical binding]; other site 698972003549 cobalt ligand [ion binding]; other site 698972003550 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 698972003551 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 698972003552 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698972003553 active site 698972003554 HIGH motif; other site 698972003555 nucleotide binding site [chemical binding]; other site 698972003556 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698972003557 active site 698972003558 KMSKS motif; other site 698972003559 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698972003560 tRNA binding surface [nucleotide binding]; other site 698972003561 anticodon binding site; other site 698972003562 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 698972003563 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 698972003564 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 698972003565 quinone interaction residues [chemical binding]; other site 698972003566 active site 698972003567 catalytic residues [active] 698972003568 FMN binding site [chemical binding]; other site 698972003569 substrate binding site [chemical binding]; other site 698972003570 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 698972003571 substrate binding site [chemical binding]; other site 698972003572 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 698972003573 membrane ATPase/protein kinase; Provisional; Region: PRK09435 698972003574 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 698972003575 Walker A; other site 698972003576 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 698972003577 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 698972003578 active site 698972003579 substrate binding site [chemical binding]; other site 698972003580 coenzyme B12 binding site [chemical binding]; other site 698972003581 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 698972003582 B12 binding site [chemical binding]; other site 698972003583 cobalt ligand [ion binding]; other site 698972003584 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 698972003585 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 698972003586 heterodimer interface [polypeptide binding]; other site 698972003587 substrate interaction site [chemical binding]; other site 698972003588 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 698972003589 Uncharacterized conserved protein [Function unknown]; Region: COG0398 698972003590 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 698972003591 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698972003592 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 698972003593 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 698972003594 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 698972003595 ferrochelatase; Reviewed; Region: hemH; PRK00035 698972003596 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 698972003597 C-terminal domain interface [polypeptide binding]; other site 698972003598 active site 698972003599 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 698972003600 active site 698972003601 N-terminal domain interface [polypeptide binding]; other site 698972003602 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698972003603 NlpC/P60 family; Region: NLPC_P60; pfam00877 698972003604 aconitate hydratase; Validated; Region: PRK09277 698972003605 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698972003606 substrate binding site [chemical binding]; other site 698972003607 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698972003608 ligand binding site [chemical binding]; other site 698972003609 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 698972003610 substrate binding site [chemical binding]; other site 698972003611 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698972003612 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698972003613 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 698972003614 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 698972003615 catalytic triad [active] 698972003616 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 698972003617 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 698972003618 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698972003619 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698972003620 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972003621 Walker A/P-loop; other site 698972003622 ATP binding site [chemical binding]; other site 698972003623 Q-loop/lid; other site 698972003624 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698972003625 ABC transporter signature motif; other site 698972003626 Walker B; other site 698972003627 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698972003628 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 698972003629 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 698972003630 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 698972003631 trimerization site [polypeptide binding]; other site 698972003632 active site 698972003633 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698972003634 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 698972003635 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698972003636 catalytic residue [active] 698972003637 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 698972003638 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 698972003639 Walker A/P-loop; other site 698972003640 ATP binding site [chemical binding]; other site 698972003641 Q-loop/lid; other site 698972003642 ABC transporter signature motif; other site 698972003643 Walker B; other site 698972003644 D-loop; other site 698972003645 H-loop/switch region; other site 698972003646 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 698972003647 FeS assembly protein SufD; Region: sufD; TIGR01981 698972003648 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 698972003649 FeS assembly protein SufB; Region: sufB; TIGR01980 698972003650 Predicted transcriptional regulator [Transcription]; Region: COG2345 698972003651 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698972003652 putative DNA binding site [nucleotide binding]; other site 698972003653 putative Zn2+ binding site [ion binding]; other site 698972003654 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698972003655 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698972003656 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698972003657 Walker A/P-loop; other site 698972003658 ATP binding site [chemical binding]; other site 698972003659 Q-loop/lid; other site 698972003660 ABC transporter signature motif; other site 698972003661 Walker B; other site 698972003662 D-loop; other site 698972003663 H-loop/switch region; other site 698972003664 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698972003665 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698972003666 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 698972003667 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 698972003668 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 698972003669 UbiA prenyltransferase family; Region: UbiA; pfam01040 698972003670 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 698972003671 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 698972003672 TPP-binding site [chemical binding]; other site 698972003673 dimer interface [polypeptide binding]; other site 698972003674 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698972003675 PYR/PP interface [polypeptide binding]; other site 698972003676 dimer interface [polypeptide binding]; other site 698972003677 TPP binding site [chemical binding]; other site 698972003678 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698972003679 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 698972003680 putative active site [active] 698972003681 transaldolase; Provisional; Region: PRK03903 698972003682 catalytic residue [active] 698972003683 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 698972003684 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 698972003685 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 698972003686 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 698972003687 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 698972003688 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698972003689 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 698972003690 putative active site [active] 698972003691 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 698972003692 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 698972003693 triosephosphate isomerase; Provisional; Region: PRK14567 698972003694 substrate binding site [chemical binding]; other site 698972003695 dimer interface [polypeptide binding]; other site 698972003696 catalytic triad [active] 698972003697 Phosphoglycerate kinase; Region: PGK; pfam00162 698972003698 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 698972003699 substrate binding site [chemical binding]; other site 698972003700 hinge regions; other site 698972003701 ADP binding site [chemical binding]; other site 698972003702 catalytic site [active] 698972003703 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 698972003704 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 698972003705 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698972003706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 698972003707 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 698972003708 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 698972003709 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 698972003710 phosphate binding site [ion binding]; other site 698972003711 putative substrate binding pocket [chemical binding]; other site 698972003712 dimer interface [polypeptide binding]; other site 698972003713 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 698972003714 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 698972003715 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 698972003716 GIY-YIG motif/motif A; other site 698972003717 active site 698972003718 catalytic site [active] 698972003719 putative DNA binding site [nucleotide binding]; other site 698972003720 metal binding site [ion binding]; metal-binding site 698972003721 UvrB/uvrC motif; Region: UVR; pfam02151 698972003722 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 698972003723 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698972003724 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 698972003725 homopentamer interface [polypeptide binding]; other site 698972003726 active site 698972003727 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 698972003728 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 698972003729 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 698972003730 dimerization interface [polypeptide binding]; other site 698972003731 active site 698972003732 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 698972003733 Lumazine binding domain; Region: Lum_binding; pfam00677 698972003734 Lumazine binding domain; Region: Lum_binding; pfam00677 698972003735 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 698972003736 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 698972003737 catalytic motif [active] 698972003738 Zn binding site [ion binding]; other site 698972003739 RibD C-terminal domain; Region: RibD_C; pfam01872 698972003740 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 698972003741 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 698972003742 substrate binding site [chemical binding]; other site 698972003743 hexamer interface [polypeptide binding]; other site 698972003744 metal binding site [ion binding]; metal-binding site 698972003745 16S rRNA methyltransferase B; Provisional; Region: PRK14902 698972003746 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 698972003747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698972003748 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 698972003749 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 698972003750 putative active site [active] 698972003751 substrate binding site [chemical binding]; other site 698972003752 putative cosubstrate binding site; other site 698972003753 catalytic site [active] 698972003754 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 698972003755 substrate binding site [chemical binding]; other site 698972003756 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698972003757 active site 698972003758 catalytic residues [active] 698972003759 metal binding site [ion binding]; metal-binding site 698972003760 primosome assembly protein PriA; Provisional; Region: PRK14873 698972003761 S-adenosylmethionine synthetase; Validated; Region: PRK05250 698972003762 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 698972003763 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 698972003764 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 698972003765 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 698972003766 Flavoprotein; Region: Flavoprotein; pfam02441 698972003767 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 698972003768 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 698972003769 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 698972003770 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 698972003771 catalytic site [active] 698972003772 G-X2-G-X-G-K; other site 698972003773 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 698972003774 active site 698972003775 dimer interface [polypeptide binding]; other site 698972003776 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 698972003777 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698972003778 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698972003779 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 698972003780 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698972003781 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698972003782 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 698972003783 IMP binding site; other site 698972003784 dimer interface [polypeptide binding]; other site 698972003785 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 698972003786 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 698972003787 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 698972003788 catalytic site [active] 698972003789 subunit interface [polypeptide binding]; other site 698972003790 dihydroorotase; Validated; Region: pyrC; PRK09357 698972003791 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698972003792 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 698972003793 active site 698972003794 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 698972003795 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698972003796 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698972003797 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 698972003798 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698972003799 active site 698972003800 hydrophobic ligand binding site; other site 698972003801 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698972003802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698972003803 TIGR01777 family protein; Region: yfcH 698972003804 NAD(P) binding site [chemical binding]; other site 698972003805 active site 698972003806 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 698972003807 elongation factor P; Validated; Region: PRK00529 698972003808 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 698972003809 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 698972003810 RNA binding site [nucleotide binding]; other site 698972003811 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 698972003812 RNA binding site [nucleotide binding]; other site 698972003813 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698972003814 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698972003815 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698972003816 active site 698972003817 Dehydroquinase class II; Region: DHquinase_II; pfam01220 698972003818 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 698972003819 trimer interface [polypeptide binding]; other site 698972003820 active site 698972003821 dimer interface [polypeptide binding]; other site 698972003822 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 698972003823 active site 698972003824 dimer interface [polypeptide binding]; other site 698972003825 metal binding site [ion binding]; metal-binding site 698972003826 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 698972003827 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 698972003828 ADP binding site [chemical binding]; other site 698972003829 magnesium binding site [ion binding]; other site 698972003830 putative shikimate binding site; other site 698972003831 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 698972003832 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 698972003833 Tetramer interface [polypeptide binding]; other site 698972003834 active site 698972003835 FMN-binding site [chemical binding]; other site 698972003836 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 698972003837 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698972003838 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698972003839 shikimate binding site; other site 698972003840 NAD(P) binding site [chemical binding]; other site 698972003841 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 698972003842 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 698972003843 dimerization interface [polypeptide binding]; other site 698972003844 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 698972003845 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 698972003846 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 698972003847 motif 1; other site 698972003848 active site 698972003849 motif 2; other site 698972003850 motif 3; other site 698972003851 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698972003852 DHHA1 domain; Region: DHHA1; pfam02272 698972003853 recombination factor protein RarA; Reviewed; Region: PRK13342 698972003854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698972003855 Walker A motif; other site 698972003856 ATP binding site [chemical binding]; other site 698972003857 Walker B motif; other site 698972003858 arginine finger; other site 698972003859 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 698972003860 Phosphotransferase enzyme family; Region: APH; pfam01636 698972003861 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698972003862 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 698972003863 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 698972003864 dimer interface [polypeptide binding]; other site 698972003865 anticodon binding site; other site 698972003866 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 698972003867 homodimer interface [polypeptide binding]; other site 698972003868 motif 1; other site 698972003869 active site 698972003870 motif 2; other site 698972003871 GAD domain; Region: GAD; pfam02938 698972003872 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698972003873 active site 698972003874 motif 3; other site 698972003875 Predicted metalloprotease [General function prediction only]; Region: COG2321 698972003876 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 698972003877 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698972003878 ATP binding site [chemical binding]; other site 698972003879 putative Mg++ binding site [ion binding]; other site 698972003880 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698972003881 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 698972003882 nucleotide binding region [chemical binding]; other site 698972003883 ATP-binding site [chemical binding]; other site 698972003884 Predicted membrane protein [Function unknown]; Region: COG1511 698972003885 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698972003886 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698972003887 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698972003888 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698972003889 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698972003890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972003891 Q-loop/lid; other site 698972003892 ABC transporter signature motif; other site 698972003893 Walker B; other site 698972003894 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698972003895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698972003896 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698972003897 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698972003898 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698972003899 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 698972003900 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 698972003901 dimer interface [polypeptide binding]; other site 698972003902 motif 1; other site 698972003903 active site 698972003904 motif 2; other site 698972003905 motif 3; other site 698972003906 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 698972003907 anticodon binding site; other site 698972003908 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698972003909 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 698972003910 dimer interface [polypeptide binding]; other site 698972003911 catalytic triad [active] 698972003912 peroxidatic and resolving cysteines [active] 698972003913 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698972003914 active site 698972003915 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698972003916 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698972003917 Zn2+ binding site [ion binding]; other site 698972003918 Mg2+ binding site [ion binding]; other site 698972003919 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698972003920 synthetase active site [active] 698972003921 NTP binding site [chemical binding]; other site 698972003922 metal binding site [ion binding]; metal-binding site 698972003923 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 698972003924 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 698972003925 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698972003926 active site 698972003927 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 698972003928 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698972003929 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 698972003930 Protein export membrane protein; Region: SecD_SecF; cl14618 698972003931 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 698972003932 Protein export membrane protein; Region: SecD_SecF; cl14618 698972003933 Preprotein translocase subunit; Region: YajC; pfam02699 698972003934 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 698972003935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698972003936 Walker A motif; other site 698972003937 ATP binding site [chemical binding]; other site 698972003938 Walker B motif; other site 698972003939 arginine finger; other site 698972003940 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 698972003941 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 698972003942 RuvA N terminal domain; Region: RuvA_N; pfam01330 698972003943 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 698972003944 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 698972003945 active site 698972003946 putative DNA-binding cleft [nucleotide binding]; other site 698972003947 dimer interface [polypeptide binding]; other site 698972003948 hypothetical protein; Validated; Region: PRK00110 698972003949 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 698972003950 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 698972003951 active site 698972003952 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 698972003953 catalytic triad [active] 698972003954 dimer interface [polypeptide binding]; other site 698972003955 Integrase core domain; Region: rve; pfam00665 698972003956 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698972003957 Helix-turn-helix domain; Region: HTH_38; pfam13936 698972003958 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698972003959 Integrase core domain; Region: rve; pfam00665 698972003960 Protein P3 of Potyviral polyprotein; Region: Potyvirid-P3; pfam13608 698972003961 Integrase core domain; Region: rve; pfam00665 698972003962 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 698972003963 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 698972003964 Nitronate monooxygenase; Region: NMO; pfam03060 698972003965 FMN binding site [chemical binding]; other site 698972003966 substrate binding site [chemical binding]; other site 698972003967 putative catalytic residue [active] 698972003968 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 698972003969 Replicase family; Region: Replicase; pfam03090 698972003970 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 698972003971 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698972003972 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698972003973 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698972003974 catalytic residues [active] 698972003975 catalytic nucleophile [active] 698972003976 Presynaptic Site I dimer interface [polypeptide binding]; other site 698972003977 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698972003978 Synaptic Flat tetramer interface [polypeptide binding]; other site 698972003979 Synaptic Site I dimer interface [polypeptide binding]; other site 698972003980 DNA binding site [nucleotide binding] 698972003981 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698972003982 MULE transposase domain; Region: MULE; pfam10551 698972003983 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698972003984 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 698972003985 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 698972003986 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698972003987 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698972003988 catalytic residue [active] 698972003989 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698972003990 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698972003991 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 698972003992 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 698972003993 putative acyl-acceptor binding pocket; other site 698972003994 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698972003995 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 698972003996 nucleotide binding site/active site [active] 698972003997 HIT family signature motif; other site 698972003998 catalytic residue [active] 698972003999 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 698972004000 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698972004001 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 698972004002 active site 698972004003 dimer interface [polypeptide binding]; other site 698972004004 motif 1; other site 698972004005 motif 2; other site 698972004006 motif 3; other site 698972004007 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 698972004008 anticodon binding site; other site 698972004009 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 698972004010 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 698972004011 Protein of unknown function (DUF461); Region: DUF461; pfam04314 698972004012 CopC domain; Region: CopC; cl01012 698972004013 hypothetical protein; Provisional; Region: PRK14059 698972004014 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 698972004015 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 698972004016 SelR domain; Region: SelR; pfam01641 698972004017 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 698972004018 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 698972004019 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 698972004020 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 698972004021 catalytic site [active] 698972004022 putative active site [active] 698972004023 putative substrate binding site [chemical binding]; other site 698972004024 HRDC domain; Region: HRDC; pfam00570 698972004025 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 698972004026 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 698972004027 TPP-binding site; other site 698972004028 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698972004029 PYR/PP interface [polypeptide binding]; other site 698972004030 dimer interface [polypeptide binding]; other site 698972004031 TPP binding site [chemical binding]; other site 698972004032 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698972004033 TRAM domain; Region: TRAM; cl01282 698972004034 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 698972004035 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 698972004036 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698972004037 trimer interface [polypeptide binding]; other site 698972004038 active site 698972004039 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 698972004040 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 698972004041 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 698972004042 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698972004043 active site 698972004044 dimerization interface [polypeptide binding]; other site 698972004045 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698972004046 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698972004047 nucleotide binding site [chemical binding]; other site 698972004048 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698972004049 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698972004050 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698972004051 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698972004052 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698972004053 DNA binding residues [nucleotide binding] 698972004054 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698972004055 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698972004056 ATP binding site [chemical binding]; other site 698972004057 putative Mg++ binding site [ion binding]; other site 698972004058 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 698972004059 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 698972004060 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 698972004061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698972004062 S-adenosylmethionine binding site [chemical binding]; other site 698972004063 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 698972004064 putative active site [active] 698972004065 dimerization interface [polypeptide binding]; other site 698972004066 putative tRNAtyr binding site [nucleotide binding]; other site 698972004067 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698972004068 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698972004069 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698972004070 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698972004071 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698972004072 DNA binding residues [nucleotide binding] 698972004073 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698972004074 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698972004075 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698972004076 FeoA domain; Region: FeoA; cl00838 698972004077 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 698972004078 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 698972004079 NAD binding site [chemical binding]; other site 698972004080 homodimer interface [polypeptide binding]; other site 698972004081 active site 698972004082 substrate binding site [chemical binding]; other site 698972004083 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 698972004084 PAC2 family; Region: PAC2; pfam09754 698972004085 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698972004086 ATP binding site [chemical binding]; other site 698972004087 putative Mg++ binding site [ion binding]; other site 698972004088 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698972004089 nucleotide binding region [chemical binding]; other site 698972004090 ATP-binding site [chemical binding]; other site 698972004091 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 698972004092 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 698972004093 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 698972004094 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698972004095 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 698972004096 dimer interface [polypeptide binding]; other site 698972004097 decamer (pentamer of dimers) interface [polypeptide binding]; other site 698972004098 catalytic triad [active] 698972004099 peroxidatic and resolving cysteines [active] 698972004100 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698972004101 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 698972004102 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 698972004103 dimerization interface [polypeptide binding]; other site 698972004104 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 698972004105 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698972004106 ATP binding site [chemical binding]; other site 698972004107 putative Mg++ binding site [ion binding]; other site 698972004108 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698972004109 nucleotide binding region [chemical binding]; other site 698972004110 ATP-binding site [chemical binding]; other site 698972004111 Helicase associated domain (HA2); Region: HA2; pfam04408 698972004112 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 698972004113 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 698972004114 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 698972004115 ATP cone domain; Region: ATP-cone; pfam03477 698972004116 LexA repressor; Validated; Region: PRK00215 698972004117 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 698972004118 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698972004119 Catalytic site [active] 698972004120 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698972004121 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 698972004122 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698972004123 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 698972004124 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 698972004125 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 698972004126 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 698972004127 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698972004128 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698972004129 DNA-binding site [nucleotide binding]; DNA binding site 698972004130 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698972004131 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 698972004132 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 698972004133 putative substrate binding site [chemical binding]; other site 698972004134 putative ATP binding site [chemical binding]; other site 698972004135 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698972004136 dimerization domain swap beta strand [polypeptide binding]; other site 698972004137 regulatory protein interface [polypeptide binding]; other site 698972004138 active site 698972004139 regulatory phosphorylation site [posttranslational modification]; other site 698972004140 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 698972004141 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698972004142 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 698972004143 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698972004144 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 698972004145 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 698972004146 GTPases [General function prediction only]; Region: HflX; COG2262 698972004147 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 698972004148 HflX GTPase family; Region: HflX; cd01878 698972004149 G1 box; other site 698972004150 GTP/Mg2+ binding site [chemical binding]; other site 698972004151 Switch I region; other site 698972004152 G2 box; other site 698972004153 G3 box; other site 698972004154 Switch II region; other site 698972004155 G4 box; other site 698972004156 G5 box; other site 698972004157 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 698972004158 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698972004159 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698972004160 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 698972004161 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 698972004162 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698972004163 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698972004164 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698972004165 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698972004166 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 698972004167 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 698972004168 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698972004169 FeS/SAM binding site; other site 698972004170 recombination regulator RecX; Reviewed; Region: recX; PRK00117 698972004171 recombinase A; Provisional; Region: recA; PRK09354 698972004172 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 698972004173 hexamer interface [polypeptide binding]; other site 698972004174 Walker A motif; other site 698972004175 ATP binding site [chemical binding]; other site 698972004176 Walker B motif; other site 698972004177 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 698972004178 BioY family; Region: BioY; pfam02632 698972004179 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698972004180 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698972004181 Walker A/P-loop; other site 698972004182 ATP binding site [chemical binding]; other site 698972004183 Q-loop/lid; other site 698972004184 ABC transporter signature motif; other site 698972004185 Walker B; other site 698972004186 D-loop; other site 698972004187 H-loop/switch region; other site 698972004188 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698972004189 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698972004190 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698972004191 sequence-specific DNA binding site [nucleotide binding]; other site 698972004192 salt bridge; other site 698972004193 Competence-damaged protein; Region: CinA; pfam02464 698972004194 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698972004195 YCII-related domain; Region: YCII; cl00999 698972004196 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 698972004197 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 698972004198 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698972004199 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 698972004200 TIGR03085 family protein; Region: TIGR03085 698972004201 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 698972004202 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698972004203 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 698972004204 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 698972004205 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698972004206 dimer interface [polypeptide binding]; other site 698972004207 active site 698972004208 catalytic residue [active] 698972004209 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 698972004210 dihydrodipicolinate reductase; Provisional; Region: PRK00048 698972004211 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 698972004212 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 698972004213 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 698972004214 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 698972004215 oligomer interface [polypeptide binding]; other site 698972004216 RNA binding site [nucleotide binding]; other site 698972004217 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 698972004218 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 698972004219 RNase E interface [polypeptide binding]; other site 698972004220 trimer interface [polypeptide binding]; other site 698972004221 active site 698972004222 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 698972004223 putative nucleic acid binding region [nucleotide binding]; other site 698972004224 G-X-X-G motif; other site 698972004225 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 698972004226 RNA binding site [nucleotide binding]; other site 698972004227 domain interface; other site 698972004228 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 698972004229 16S/18S rRNA binding site [nucleotide binding]; other site 698972004230 S13e-L30e interaction site [polypeptide binding]; other site 698972004231 25S rRNA binding site [nucleotide binding]; other site 698972004232 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 698972004233 active site 698972004234 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 698972004235 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 698972004236 active site 698972004237 Riboflavin kinase; Region: Flavokinase; smart00904 698972004238 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 698972004239 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 698972004240 RNA binding site [nucleotide binding]; other site 698972004241 active site 698972004242 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 698972004243 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 698972004244 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 698972004245 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698972004246 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698972004247 active site 698972004248 metal binding site [ion binding]; metal-binding site 698972004249 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698972004250 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 698972004251 DHH family; Region: DHH; pfam01368 698972004252 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 698972004253 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698972004254 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698972004255 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 698972004256 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 698972004257 G1 box; other site 698972004258 putative GEF interaction site [polypeptide binding]; other site 698972004259 GTP/Mg2+ binding site [chemical binding]; other site 698972004260 Switch I region; other site 698972004261 G2 box; other site 698972004262 G3 box; other site 698972004263 Switch II region; other site 698972004264 G4 box; other site 698972004265 G5 box; other site 698972004266 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 698972004267 Translation-initiation factor 2; Region: IF-2; pfam11987 698972004268 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 698972004269 Protein of unknown function (DUF448); Region: DUF448; pfam04296 698972004270 putative RNA binding cleft [nucleotide binding]; other site 698972004271 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 698972004272 NusA N-terminal domain; Region: NusA_N; pfam08529 698972004273 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 698972004274 RNA binding site [nucleotide binding]; other site 698972004275 homodimer interface [polypeptide binding]; other site 698972004276 NusA-like KH domain; Region: KH_5; pfam13184 698972004277 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 698972004278 G-X-X-G motif; other site 698972004279 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 698972004280 Sm and related proteins; Region: Sm_like; cl00259 698972004281 prolyl-tRNA synthetase; Provisional; Region: PRK09194 698972004282 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 698972004283 dimer interface [polypeptide binding]; other site 698972004284 motif 1; other site 698972004285 active site 698972004286 motif 2; other site 698972004287 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 698972004288 putative deacylase active site [active] 698972004289 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698972004290 active site 698972004291 motif 3; other site 698972004292 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 698972004293 anticodon binding site; other site 698972004294 hypothetical protein; Validated; Region: PRK02101 698972004295 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 698972004296 active site 698972004297 SAM binding site [chemical binding]; other site 698972004298 homodimer interface [polypeptide binding]; other site 698972004299 Uncharacterized conserved protein [Function unknown]; Region: COG0397 698972004300 hypothetical protein; Validated; Region: PRK00029 698972004301 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698972004302 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 698972004303 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 698972004304 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 698972004305 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698972004306 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 698972004307 catalytic triad [active] 698972004308 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 698972004309 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 698972004310 Walker A motif; other site 698972004311 homodimer interface [polypeptide binding]; other site 698972004312 ATP binding site [chemical binding]; other site 698972004313 hydroxycobalamin binding site [chemical binding]; other site 698972004314 Walker B motif; other site 698972004315 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 698972004316 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 698972004317 metal ion-dependent adhesion site (MIDAS); other site 698972004318 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 698972004319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698972004320 Walker A motif; other site 698972004321 ATP binding site [chemical binding]; other site 698972004322 Walker B motif; other site 698972004323 arginine finger; other site 698972004324 malate:quinone oxidoreductase; Validated; Region: PRK05257 698972004325 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 698972004326 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698972004327 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698972004328 mycothione reductase; Region: mycothione_red; TIGR03452 698972004329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698972004330 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698972004331 cobyric acid synthase; Provisional; Region: PRK00784 698972004332 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 698972004333 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698972004334 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698972004335 catalytic triad [active] 698972004336 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698972004337 active site 698972004338 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 698972004339 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698972004340 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 698972004341 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698972004342 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698972004343 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 698972004344 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698972004345 active site 698972004346 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 698972004347 protein binding site [polypeptide binding]; other site 698972004348 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 698972004349 putative substrate binding region [chemical binding]; other site 698972004350 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 698972004351 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 698972004352 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 698972004353 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 698972004354 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 698972004355 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 698972004356 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698972004357 FeS/SAM binding site; other site 698972004358 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 698972004359 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 698972004360 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 698972004361 ribosome recycling factor; Reviewed; Region: frr; PRK00083 698972004362 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 698972004363 hinge region; other site 698972004364 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 698972004365 putative nucleotide binding site [chemical binding]; other site 698972004366 uridine monophosphate binding site [chemical binding]; other site 698972004367 homohexameric interface [polypeptide binding]; other site 698972004368 elongation factor Ts; Provisional; Region: tsf; PRK09377 698972004369 UBA/TS-N domain; Region: UBA; pfam00627 698972004370 Elongation factor TS; Region: EF_TS; pfam00889 698972004371 Elongation factor TS; Region: EF_TS; pfam00889 698972004372 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 698972004373 rRNA interaction site [nucleotide binding]; other site 698972004374 S8 interaction site; other site 698972004375 putative laminin-1 binding site; other site 698972004376 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698972004377 Peptidase family M23; Region: Peptidase_M23; pfam01551 698972004378 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698972004379 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 698972004380 active site 698972004381 DNA binding site [nucleotide binding] 698972004382 Int/Topo IB signature motif; other site 698972004383 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 698972004384 DNA protecting protein DprA; Region: dprA; TIGR00732 698972004385 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 698972004386 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698972004387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698972004388 Walker A motif; other site 698972004389 ATP binding site [chemical binding]; other site 698972004390 Walker B motif; other site 698972004391 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 698972004392 hypothetical protein; Reviewed; Region: PRK12497 698972004393 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 698972004394 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 698972004395 RNA/DNA hybrid binding site [nucleotide binding]; other site 698972004396 active site 698972004397 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 698972004398 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698972004399 Catalytic site [active] 698972004400 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698972004401 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 698972004402 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 698972004403 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 698972004404 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 698972004405 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698972004406 RNA binding site [nucleotide binding]; other site 698972004407 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 698972004408 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 698972004409 RimM N-terminal domain; Region: RimM; pfam01782 698972004410 PRC-barrel domain; Region: PRC; pfam05239 698972004411 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 698972004412 signal recognition particle protein; Provisional; Region: PRK10867 698972004413 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 698972004414 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 698972004415 P loop; other site 698972004416 GTP binding site [chemical binding]; other site 698972004417 Signal peptide binding domain; Region: SRP_SPB; pfam02978 698972004418 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 698972004419 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698972004420 metal binding triad; other site 698972004421 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698972004422 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 698972004423 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 698972004424 Nitrogen regulatory protein P-II; Region: P-II; smart00938 698972004425 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 698972004426 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 698972004427 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 698972004428 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698972004429 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 698972004430 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698972004431 Walker A/P-loop; other site 698972004432 ATP binding site [chemical binding]; other site 698972004433 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 698972004434 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698972004435 ABC transporter signature motif; other site 698972004436 Walker B; other site 698972004437 D-loop; other site 698972004438 H-loop/switch region; other site 698972004439 Acylphosphatase; Region: Acylphosphatase; cl00551 698972004440 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698972004441 amino acid carrier protein; Region: agcS; TIGR00835 698972004442 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 698972004443 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 698972004444 DNA binding site [nucleotide binding] 698972004445 catalytic residue [active] 698972004446 H2TH interface [polypeptide binding]; other site 698972004447 putative catalytic residues [active] 698972004448 turnover-facilitating residue; other site 698972004449 intercalation triad [nucleotide binding]; other site 698972004450 8OG recognition residue [nucleotide binding]; other site 698972004451 putative reading head residues; other site 698972004452 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698972004453 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698972004454 ribonuclease III; Reviewed; Region: rnc; PRK00102 698972004455 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 698972004456 dimerization interface [polypeptide binding]; other site 698972004457 active site 698972004458 metal binding site [ion binding]; metal-binding site 698972004459 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 698972004460 dsRNA binding site [nucleotide binding]; other site 698972004461 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 698972004462 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698972004463 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 698972004464 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 698972004465 active site 698972004466 catalytic site [active] 698972004467 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 698972004468 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 698972004469 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 698972004470 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 698972004471 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 698972004472 RNA binding site [nucleotide binding]; other site 698972004473 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 698972004474 Winged helix-turn helix; Region: HTH_29; pfam13551 698972004475 Integrase core domain; Region: rve; pfam00665 698972004476 Integrase core domain; Region: rve_3; cl15866 698972004477 glutamate dehydrogenase; Provisional; Region: PRK09414 698972004478 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 698972004479 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 698972004480 NAD(P) binding site [chemical binding]; other site 698972004481 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 698972004482 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698972004483 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698972004484 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 698972004485 metal binding site [ion binding]; metal-binding site 698972004486 putative dimer interface [polypeptide binding]; other site 698972004487 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 698972004488 homodimer interface [polypeptide binding]; other site 698972004489 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 698972004490 active site pocket [active] 698972004491 pyruvate kinase; Provisional; Region: PRK06247 698972004492 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 698972004493 domain interfaces; other site 698972004494 active site 698972004495 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 698972004496 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698972004497 active site 698972004498 ribulose/triose binding site [chemical binding]; other site 698972004499 phosphate binding site [ion binding]; other site 698972004500 substrate (anthranilate) binding pocket [chemical binding]; other site 698972004501 product (indole) binding pocket [chemical binding]; other site 698972004502 trp region conserved hypothetical membrane protein; Region: trp_oprn_chp; TIGR02234 698972004503 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 698972004504 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 698972004505 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698972004506 substrate binding site [chemical binding]; other site 698972004507 glutamase interaction surface [polypeptide binding]; other site 698972004508 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698972004509 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698972004510 active site 698972004511 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 698972004512 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698972004513 catalytic residues [active] 698972004514 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 698972004515 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 698972004516 putative active site [active] 698972004517 oxyanion strand; other site 698972004518 catalytic triad [active] 698972004519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972004520 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698972004521 putative substrate translocation pore; other site 698972004522 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 698972004523 putative active site pocket [active] 698972004524 4-fold oligomerization interface [polypeptide binding]; other site 698972004525 metal binding residues [ion binding]; metal-binding site 698972004526 3-fold/trimer interface [polypeptide binding]; other site 698972004527 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 698972004528 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698972004529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698972004530 homodimer interface [polypeptide binding]; other site 698972004531 catalytic residue [active] 698972004532 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 698972004533 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 698972004534 NAD binding site [chemical binding]; other site 698972004535 dimerization interface [polypeptide binding]; other site 698972004536 product binding site; other site 698972004537 substrate binding site [chemical binding]; other site 698972004538 zinc binding site [ion binding]; other site 698972004539 catalytic residues [active] 698972004540 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 698972004541 tetracycline repressor protein TetR; Provisional; Region: PRK13756 698972004542 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698972004543 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 698972004544 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 698972004545 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 698972004546 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 698972004547 active site 698972004548 catalytic site [active] 698972004549 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 698972004550 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 698972004551 active site 698972004552 catalytic site [active] 698972004553 substrate binding site [chemical binding]; other site 698972004554 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698972004555 synthetase active site [active] 698972004556 NTP binding site [chemical binding]; other site 698972004557 metal binding site [ion binding]; metal-binding site 698972004558 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698972004559 RNA binding surface [nucleotide binding]; other site 698972004560 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 698972004561 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 698972004562 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 698972004563 threonine dehydratase; Validated; Region: PRK08639 698972004564 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698972004565 tetramer interface [polypeptide binding]; other site 698972004566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698972004567 catalytic residue [active] 698972004568 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 698972004569 putative Ile/Val binding site [chemical binding]; other site 698972004570 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 698972004571 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 698972004572 active site 698972004573 PHP Thumb interface [polypeptide binding]; other site 698972004574 metal binding site [ion binding]; metal-binding site 698972004575 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698972004576 generic binding surface II; other site 698972004577 generic binding surface I; other site 698972004578 Predicted permeases [General function prediction only]; Region: RarD; COG2962 698972004579 EamA-like transporter family; Region: EamA; cl17759 698972004580 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 698972004581 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698972004582 RNA binding surface [nucleotide binding]; other site 698972004583 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698972004584 active site 698972004585 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 698972004586 lipoprotein signal peptidase; Provisional; Region: PRK14787 698972004587 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698972004588 active site 698972004589 homotetramer interface [polypeptide binding]; other site 698972004590 homodimer interface [polypeptide binding]; other site 698972004591 DNA polymerase IV; Provisional; Region: PRK03348 698972004592 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 698972004593 active site 698972004594 DNA binding site [nucleotide binding] 698972004595 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 698972004596 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698972004597 HIGH motif; other site 698972004598 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698972004599 active site 698972004600 KMSKS motif; other site 698972004601 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 698972004602 tRNA binding surface [nucleotide binding]; other site 698972004603 anticodon binding site; other site 698972004604 DivIVA domain; Region: DivI1A_domain; TIGR03544 698972004605 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698972004606 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 698972004607 YGGT family; Region: YGGT; cl00508 698972004608 Protein of unknown function (DUF552); Region: DUF552; cl00775 698972004609 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 698972004610 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 698972004611 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 698972004612 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 698972004613 nucleotide binding site [chemical binding]; other site 698972004614 SulA interaction site; other site 698972004615 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 698972004616 Cell division protein FtsQ; Region: FtsQ; pfam03799 698972004617 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 698972004618 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698972004619 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698972004620 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698972004621 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 698972004622 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 698972004623 active site 698972004624 homodimer interface [polypeptide binding]; other site 698972004625 cell division protein FtsW; Region: ftsW; TIGR02614 698972004626 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 698972004627 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698972004628 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698972004629 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 698972004630 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 698972004631 Mg++ binding site [ion binding]; other site 698972004632 putative catalytic motif [active] 698972004633 putative substrate binding site [chemical binding]; other site 698972004634 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 698972004635 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698972004636 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698972004637 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698972004638 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 698972004639 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698972004640 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698972004641 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698972004642 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698972004643 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698972004644 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698972004645 MraW methylase family; Region: Methyltransf_5; cl17771 698972004646 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 698972004647 cell division protein MraZ; Reviewed; Region: PRK00326 698972004648 MraZ protein; Region: MraZ; pfam02381 698972004649 MraZ protein; Region: MraZ; pfam02381 698972004650 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 698972004651 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698972004652 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698972004653 Coenzyme A binding pocket [chemical binding]; other site 698972004654 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698972004655 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698972004656 substrate binding pocket [chemical binding]; other site 698972004657 chain length determination region; other site 698972004658 substrate-Mg2+ binding site; other site 698972004659 catalytic residues [active] 698972004660 aspartate-rich region 1; other site 698972004661 active site lid residues [active] 698972004662 aspartate-rich region 2; other site 698972004663 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698972004664 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698972004665 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698972004666 active site 698972004667 ATP binding site [chemical binding]; other site 698972004668 substrate binding site [chemical binding]; other site 698972004669 activation loop (A-loop); other site 698972004670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698972004671 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698972004672 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698972004673 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698972004674 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698972004675 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 698972004676 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698972004677 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698972004678 putative acyl-acceptor binding pocket; other site 698972004679 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698972004680 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698972004681 nucleotide binding site [chemical binding]; other site 698972004682 Tesmin/TSO1-like CXC domain; Region: CXC; pfam03638 698972004683 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698972004684 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698972004685 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698972004686 NlpC/P60 family; Region: NLPC_P60; pfam00877 698972004687 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698972004688 NlpC/P60 family; Region: NLPC_P60; pfam00877 698972004689 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 698972004690 heme bH binding site [chemical binding]; other site 698972004691 intrachain domain interface; other site 698972004692 heme bL binding site [chemical binding]; other site 698972004693 interchain domain interface [polypeptide binding]; other site 698972004694 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 698972004695 Qo binding site; other site 698972004696 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 698972004697 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698972004698 iron-sulfur cluster [ion binding]; other site 698972004699 [2Fe-2S] cluster binding site [ion binding]; other site 698972004700 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698972004701 Cytochrome c; Region: Cytochrom_C; pfam00034 698972004702 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698972004703 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 698972004704 Subunit I/III interface [polypeptide binding]; other site 698972004705 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 698972004706 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 698972004707 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 698972004708 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 698972004709 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 698972004710 active site 698972004711 dimer interface [polypeptide binding]; other site 698972004712 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 698972004713 Ligand Binding Site [chemical binding]; other site 698972004714 Molecular Tunnel; other site 698972004715 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 698972004716 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 698972004717 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 698972004718 homotrimer interface [polypeptide binding]; other site 698972004719 Walker A motif; other site 698972004720 GTP binding site [chemical binding]; other site 698972004721 Walker B motif; other site 698972004722 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 698972004723 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 698972004724 putative dimer interface [polypeptide binding]; other site 698972004725 active site pocket [active] 698972004726 putative cataytic base [active] 698972004727 cobalamin synthase; Reviewed; Region: cobS; PRK00235 698972004728 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 698972004729 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 698972004730 homodimer interface [polypeptide binding]; other site 698972004731 substrate-cofactor binding pocket; other site 698972004732 catalytic residue [active] 698972004733 multifunctional aminopeptidase A; Provisional; Region: PRK00913 698972004734 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 698972004735 interface (dimer of trimers) [polypeptide binding]; other site 698972004736 Substrate-binding/catalytic site; other site 698972004737 Zn-binding sites [ion binding]; other site 698972004738 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 698972004739 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698972004740 E3 interaction surface; other site 698972004741 lipoyl attachment site [posttranslational modification]; other site 698972004742 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698972004743 E3 interaction surface; other site 698972004744 lipoyl attachment site [posttranslational modification]; other site 698972004745 e3 binding domain; Region: E3_binding; pfam02817 698972004746 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698972004747 lipoate-protein ligase B; Provisional; Region: PRK14345 698972004748 lipoyl synthase; Provisional; Region: PRK05481 698972004749 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698972004750 FeS/SAM binding site; other site 698972004751 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 698972004752 RDD family; Region: RDD; pfam06271 698972004753 glutamine synthetase, type I; Region: GlnA; TIGR00653 698972004754 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698972004755 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698972004756 Predicted peptidase [General function prediction only]; Region: COG4099 698972004757 CsbD-like; Region: CsbD; pfam05532 698972004758 Predicted permease [General function prediction only]; Region: COG2056 698972004759 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 698972004760 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698972004761 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698972004762 DNA-binding site [nucleotide binding]; DNA binding site 698972004763 FCD domain; Region: FCD; pfam07729 698972004764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972004765 putative substrate translocation pore; other site 698972004766 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698972004767 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 698972004768 nudix motif; other site 698972004769 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 698972004770 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 698972004771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698972004772 catalytic residue [active] 698972004773 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 698972004774 active site 698972004775 catalytic site [active] 698972004776 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 698972004777 heme binding pocket [chemical binding]; other site 698972004778 heme ligand [chemical binding]; other site 698972004779 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 698972004780 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698972004781 metal binding triad; other site 698972004782 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698972004783 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698972004784 metal binding triad; other site 698972004785 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698972004786 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 698972004787 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698972004788 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698972004789 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 698972004790 putative active site; other site 698972004791 putative metal binding residues [ion binding]; other site 698972004792 signature motif; other site 698972004793 putative triphosphate binding site [ion binding]; other site 698972004794 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 698972004795 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 698972004796 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698972004797 potential frameshift: common BLAST hit: gi|300858911|ref|YP_003783894.1| ribonuclease R 698972004798 RNB domain; Region: RNB; pfam00773 698972004799 Predicted membrane protein [General function prediction only]; Region: COG4194 698972004800 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 698972004801 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 698972004802 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 698972004803 RNA/DNA hybrid binding site [nucleotide binding]; other site 698972004804 active site 698972004805 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698972004806 catalytic core [active] 698972004807 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 698972004808 Putative zinc ribbon domain; Region: DUF164; pfam02591 698972004809 Uncharacterized conserved protein [Function unknown]; Region: COG0327 698972004810 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698972004811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 698972004812 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698972004813 hypothetical protein; Provisional; Region: PRK07908 698972004814 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698972004815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698972004816 homodimer interface [polypeptide binding]; other site 698972004817 catalytic residue [active] 698972004818 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 698972004819 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698972004820 motif II; other site 698972004821 Low molecular weight phosphatase family; Region: LMWPc; cd00115 698972004822 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 698972004823 active site 698972004824 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 698972004825 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 698972004826 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 698972004827 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 698972004828 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 698972004829 dimer interface [polypeptide binding]; other site 698972004830 TPP-binding site [chemical binding]; other site 698972004831 Electron transfer DM13; Region: DM13; pfam10517 698972004832 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698972004833 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698972004834 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698972004835 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 698972004836 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698972004837 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698972004838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698972004839 active site 698972004840 motif I; other site 698972004841 motif II; other site 698972004842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698972004843 motif II; other site 698972004844 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698972004845 Beta-lactamase; Region: Beta-lactamase; pfam00144 698972004846 Predicted membrane protein [Function unknown]; Region: COG2860 698972004847 UPF0126 domain; Region: UPF0126; pfam03458 698972004848 UPF0126 domain; Region: UPF0126; pfam03458 698972004849 DNA primase; Validated; Region: dnaG; PRK05667 698972004850 CHC2 zinc finger; Region: zf-CHC2; pfam01807 698972004851 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 698972004852 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 698972004853 active site 698972004854 metal binding site [ion binding]; metal-binding site 698972004855 interdomain interaction site; other site 698972004856 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 698972004857 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 698972004858 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 698972004859 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 698972004860 glutaminase active site [active] 698972004861 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698972004862 dimer interface [polypeptide binding]; other site 698972004863 active site 698972004864 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 698972004865 dimer interface [polypeptide binding]; other site 698972004866 active site 698972004867 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 698972004868 active site 698972004869 barstar interaction site; other site 698972004870 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 698972004871 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698972004872 Zn2+ binding site [ion binding]; other site 698972004873 Mg2+ binding site [ion binding]; other site 698972004874 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 698972004875 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698972004876 putative active site [active] 698972004877 Repair protein; Region: Repair_PSII; pfam04536 698972004878 glycyl-tRNA synthetase; Provisional; Region: PRK04173 698972004879 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698972004880 motif 1; other site 698972004881 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 698972004882 active site 698972004883 motif 2; other site 698972004884 motif 3; other site 698972004885 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 698972004886 anticodon binding site; other site 698972004887 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698972004888 putative DNA binding site [nucleotide binding]; other site 698972004889 dimerization interface [polypeptide binding]; other site 698972004890 putative Zn2+ binding site [ion binding]; other site 698972004891 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698972004892 metal binding site 2 [ion binding]; metal-binding site 698972004893 putative DNA binding helix; other site 698972004894 metal binding site 1 [ion binding]; metal-binding site 698972004895 dimer interface [polypeptide binding]; other site 698972004896 structural Zn2+ binding site [ion binding]; other site 698972004897 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 698972004898 diiron binding motif [ion binding]; other site 698972004899 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 698972004900 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698972004901 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 698972004902 catalytic residue [active] 698972004903 putative FPP diphosphate binding site; other site 698972004904 putative FPP binding hydrophobic cleft; other site 698972004905 dimer interface [polypeptide binding]; other site 698972004906 putative IPP diphosphate binding site; other site 698972004907 Recombination protein O N terminal; Region: RecO_N; pfam11967 698972004908 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 698972004909 Recombination protein O C terminal; Region: RecO_C; pfam02565 698972004910 GTPase Era; Reviewed; Region: era; PRK00089 698972004911 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 698972004912 G1 box; other site 698972004913 GTP/Mg2+ binding site [chemical binding]; other site 698972004914 Switch I region; other site 698972004915 G2 box; other site 698972004916 Switch II region; other site 698972004917 G3 box; other site 698972004918 G4 box; other site 698972004919 G5 box; other site 698972004920 KH domain; Region: KH_2; pfam07650 698972004921 pyridoxamine kinase; Validated; Region: PRK05756 698972004922 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 698972004923 dimer interface [polypeptide binding]; other site 698972004924 pyridoxal binding site [chemical binding]; other site 698972004925 ATP binding site [chemical binding]; other site 698972004926 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698972004927 Domain of unknown function DUF21; Region: DUF21; pfam01595 698972004928 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698972004929 Transporter associated domain; Region: CorC_HlyC; smart01091 698972004930 metal-binding heat shock protein; Provisional; Region: PRK00016 698972004931 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 698972004932 PhoH-like protein; Region: PhoH; pfam02562 698972004933 RNA methyltransferase, RsmE family; Region: TIGR00046 698972004934 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 698972004935 chaperone protein DnaJ; Provisional; Region: PRK14278 698972004936 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698972004937 HSP70 interaction site [polypeptide binding]; other site 698972004938 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698972004939 Zn binding sites [ion binding]; other site 698972004940 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698972004941 dimer interface [polypeptide binding]; other site 698972004942 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 698972004943 coproporphyrinogen III oxidase; Validated; Region: PRK05628 698972004944 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698972004945 FeS/SAM binding site; other site 698972004946 HemN C-terminal domain; Region: HemN_C; pfam06969 698972004947 potential frameshift: common BLAST hit: gi|38234295|ref|NP_940062.1| surface-anchored membrane protein 698972004948 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698972004949 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698972004950 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698972004951 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698972004952 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 698972004953 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 698972004954 acyl-activating enzyme (AAE) consensus motif; other site 698972004955 putative AMP binding site [chemical binding]; other site 698972004956 putative active site [active] 698972004957 putative CoA binding site [chemical binding]; other site 698972004958 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 698972004959 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 698972004960 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 698972004961 active site 698972004962 Zn binding site [ion binding]; other site 698972004963 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698972004964 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698972004965 substrate binding pocket [chemical binding]; other site 698972004966 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 698972004967 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 698972004968 active site 698972004969 metal binding site [ion binding]; metal-binding site 698972004970 nudix motif; other site 698972004971 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698972004972 active site 698972004973 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698972004974 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698972004975 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972004976 Walker A/P-loop; other site 698972004977 ATP binding site [chemical binding]; other site 698972004978 Q-loop/lid; other site 698972004979 ABC transporter signature motif; other site 698972004980 Walker B; other site 698972004981 D-loop; other site 698972004982 H-loop/switch region; other site 698972004983 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 698972004984 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698972004985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698972004986 homodimer interface [polypeptide binding]; other site 698972004987 catalytic residue [active] 698972004988 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 698972004989 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698972004990 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 698972004991 BCCT family transporter; Region: BCCT; pfam02028 698972004992 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698972004993 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 698972004994 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698972004995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698972004996 dimer interface [polypeptide binding]; other site 698972004997 conserved gate region; other site 698972004998 putative PBP binding loops; other site 698972004999 ABC-ATPase subunit interface; other site 698972005000 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698972005001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698972005002 dimer interface [polypeptide binding]; other site 698972005003 conserved gate region; other site 698972005004 putative PBP binding loops; other site 698972005005 ABC-ATPase subunit interface; other site 698972005006 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698972005007 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698972005008 Walker A/P-loop; other site 698972005009 ATP binding site [chemical binding]; other site 698972005010 Q-loop/lid; other site 698972005011 ABC transporter signature motif; other site 698972005012 Walker B; other site 698972005013 D-loop; other site 698972005014 H-loop/switch region; other site 698972005015 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698972005016 Walker A/P-loop; other site 698972005017 ATP binding site [chemical binding]; other site 698972005018 Q-loop/lid; other site 698972005019 ABC transporter signature motif; other site 698972005020 Walker B; other site 698972005021 D-loop; other site 698972005022 H-loop/switch region; other site 698972005023 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698972005024 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 698972005025 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698972005026 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698972005027 nucleotide binding site [chemical binding]; other site 698972005028 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 698972005029 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698972005030 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698972005031 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 698972005032 active site residue [active] 698972005033 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 698972005034 putative homodimer interface [polypeptide binding]; other site 698972005035 putative homotetramer interface [polypeptide binding]; other site 698972005036 putative allosteric switch controlling residues; other site 698972005037 putative metal binding site [ion binding]; other site 698972005038 putative homodimer-homodimer interface [polypeptide binding]; other site 698972005039 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 698972005040 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698972005041 TrkA-N domain; Region: TrkA_N; pfam02254 698972005042 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 698972005043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972005044 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698972005045 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 698972005046 active site 698972005047 tetramer interface [polypeptide binding]; other site 698972005048 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698972005049 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 698972005050 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698972005051 Mrr N-terminal domain; Region: Mrr_N; pfam14338 698972005052 Restriction endonuclease; Region: Mrr_cat; pfam04471 698972005053 Abi-like protein; Region: Abi_2; pfam07751 698972005054 potential protein location (hypothetical protein) that overlaps protein (putative secreted protein) 698972005055 AAA ATPase domain; Region: AAA_16; pfam13191 698972005056 GTP-binding protein LepA; Provisional; Region: PRK05433 698972005057 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 698972005058 G1 box; other site 698972005059 putative GEF interaction site [polypeptide binding]; other site 698972005060 GTP/Mg2+ binding site [chemical binding]; other site 698972005061 Switch I region; other site 698972005062 G2 box; other site 698972005063 G3 box; other site 698972005064 Switch II region; other site 698972005065 G4 box; other site 698972005066 G5 box; other site 698972005067 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 698972005068 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 698972005069 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 698972005070 PemK-like protein; Region: PemK; pfam02452 698972005071 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 698972005072 LysE type translocator; Region: LysE; cl00565 698972005073 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 698972005074 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 698972005075 hypothetical protein; Validated; Region: PRK05629 698972005076 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 698972005077 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 698972005078 Competence protein; Region: Competence; pfam03772 698972005079 comEA protein; Region: comE; TIGR01259 698972005080 Helix-hairpin-helix motif; Region: HHH; pfam00633 698972005081 helix-hairpin-helix signature motif; other site 698972005082 EDD domain protein, DegV family; Region: DegV; TIGR00762 698972005083 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 698972005084 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698972005085 catalytic core [active] 698972005086 Oligomerisation domain; Region: Oligomerisation; cl00519 698972005087 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 698972005088 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 698972005089 active site 698972005090 (T/H)XGH motif; other site 698972005091 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 698972005092 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 698972005093 putative catalytic cysteine [active] 698972005094 gamma-glutamyl kinase; Provisional; Region: PRK05429 698972005095 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 698972005096 nucleotide binding site [chemical binding]; other site 698972005097 homotetrameric interface [polypeptide binding]; other site 698972005098 putative phosphate binding site [ion binding]; other site 698972005099 putative allosteric binding site; other site 698972005100 PUA domain; Region: PUA; pfam01472 698972005101 GTPase CgtA; Reviewed; Region: obgE; PRK12296 698972005102 GTP1/OBG; Region: GTP1_OBG; pfam01018 698972005103 Obg GTPase; Region: Obg; cd01898 698972005104 G1 box; other site 698972005105 GTP/Mg2+ binding site [chemical binding]; other site 698972005106 Switch I region; other site 698972005107 G2 box; other site 698972005108 G3 box; other site 698972005109 Switch II region; other site 698972005110 G4 box; other site 698972005111 G5 box; other site 698972005112 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 698972005113 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 698972005114 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 698972005115 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 698972005116 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698972005117 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 698972005118 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 698972005119 homodimer interface [polypeptide binding]; other site 698972005120 oligonucleotide binding site [chemical binding]; other site 698972005121 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 698972005122 active site 698972005123 multimer interface [polypeptide binding]; other site 698972005124 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 698972005125 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 698972005126 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698972005127 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 698972005128 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698972005129 active site 698972005130 HIGH motif; other site 698972005131 nucleotide binding site [chemical binding]; other site 698972005132 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698972005133 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 698972005134 active site 698972005135 KMSKS motif; other site 698972005136 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 698972005137 tRNA binding surface [nucleotide binding]; other site 698972005138 anticodon binding site; other site 698972005139 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 698972005140 malate dehydrogenase; Provisional; Region: PRK05442 698972005141 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 698972005142 NAD(P) binding site [chemical binding]; other site 698972005143 dimer interface [polypeptide binding]; other site 698972005144 malate binding site [chemical binding]; other site 698972005145 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698972005146 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698972005147 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 698972005148 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 698972005149 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 698972005150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698972005151 Walker A motif; other site 698972005152 ATP binding site [chemical binding]; other site 698972005153 Walker B motif; other site 698972005154 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 698972005155 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698972005156 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698972005157 glutamine binding [chemical binding]; other site 698972005158 catalytic triad [active] 698972005159 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 698972005160 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698972005161 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 698972005162 substrate-cofactor binding pocket; other site 698972005163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698972005164 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 698972005165 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698972005166 oligomer interface [polypeptide binding]; other site 698972005167 active site residues [active] 698972005168 Clp protease; Region: CLP_protease; pfam00574 698972005169 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698972005170 oligomer interface [polypeptide binding]; other site 698972005171 active site residues [active] 698972005172 trigger factor; Provisional; Region: tig; PRK01490 698972005173 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698972005174 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 698972005175 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 698972005176 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698972005177 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698972005178 catalytic residues [active] 698972005179 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 698972005180 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 698972005181 Zn binding site [ion binding]; other site 698972005182 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698972005183 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698972005184 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 698972005185 apolar tunnel; other site 698972005186 heme binding site [chemical binding]; other site 698972005187 dimerization interface [polypeptide binding]; other site 698972005188 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698972005189 active site 698972005190 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 698972005191 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972005192 Walker A/P-loop; other site 698972005193 ATP binding site [chemical binding]; other site 698972005194 Q-loop/lid; other site 698972005195 ABC transporter signature motif; other site 698972005196 Walker B; other site 698972005197 D-loop; other site 698972005198 H-loop/switch region; other site 698972005199 ABC transporter; Region: ABC_tran_2; pfam12848 698972005200 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698972005201 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698972005202 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698972005203 dimer interface [polypeptide binding]; other site 698972005204 ssDNA binding site [nucleotide binding]; other site 698972005205 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698972005206 Copper resistance protein D; Region: CopD; pfam05425 698972005207 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 698972005208 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 698972005209 Carbon starvation protein CstA; Region: CstA; pfam02554 698972005210 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 698972005211 Protein of unknown function (DUF466); Region: DUF466; pfam04328 698972005212 putative transposase OrfB; Reviewed; Region: PHA02517 698972005213 HTH-like domain; Region: HTH_21; pfam13276 698972005214 Integrase core domain; Region: rve; pfam00665 698972005215 Integrase core domain; Region: rve_2; pfam13333 698972005216 Homeodomain-like domain; Region: HTH_23; cl17451 698972005217 Helix-turn-helix domain; Region: HTH_28; pfam13518 698972005218 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698972005219 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 698972005220 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 698972005221 NADP binding site [chemical binding]; other site 698972005222 dimer interface [polypeptide binding]; other site 698972005223 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698972005224 classical (c) SDRs; Region: SDR_c; cd05233 698972005225 NAD(P) binding site [chemical binding]; other site 698972005226 active site 698972005227 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 698972005228 catalytic site [active] 698972005229 putative active site [active] 698972005230 putative substrate binding site [chemical binding]; other site 698972005231 dimer interface [polypeptide binding]; other site 698972005232 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698972005233 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698972005234 inhibitor site; inhibition site 698972005235 active site 698972005236 dimer interface [polypeptide binding]; other site 698972005237 catalytic residue [active] 698972005238 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 698972005239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698972005240 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 698972005241 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698972005242 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 698972005243 conserved cis-peptide bond; other site 698972005244 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 698972005245 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 698972005246 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698972005247 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 698972005248 catalytic triad [active] 698972005249 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698972005250 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698972005251 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 698972005252 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698972005253 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 698972005254 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698972005255 phosphate binding site [ion binding]; other site 698972005256 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 698972005257 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 698972005258 active site 2 [active] 698972005259 active site 1 [active] 698972005260 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 698972005261 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698972005262 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 698972005263 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 698972005264 putative NAD(P) binding site [chemical binding]; other site 698972005265 active site 698972005266 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 698972005267 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 698972005268 active site 698972005269 Glucitol operon activator protein (GutM); Region: GutM; cl01890 698972005270 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 698972005271 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 698972005272 active site 698972005273 dimerization interface [polypeptide binding]; other site 698972005274 ribonuclease PH; Reviewed; Region: rph; PRK00173 698972005275 Ribonuclease PH; Region: RNase_PH_bact; cd11362 698972005276 hexamer interface [polypeptide binding]; other site 698972005277 active site 698972005278 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 698972005279 glutamate racemase; Provisional; Region: PRK00865 698972005280 Rhomboid family; Region: Rhomboid; cl11446 698972005281 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 698972005282 putative active site pocket [active] 698972005283 cleavage site 698972005284 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 698972005285 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 698972005286 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 698972005287 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 698972005288 active site 698972005289 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 698972005290 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698972005291 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698972005292 putative Mg++ binding site [ion binding]; other site 698972005293 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 698972005294 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698972005295 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698972005296 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698972005297 active site 698972005298 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698972005299 MULE transposase domain; Region: MULE; pfam10551 698972005300 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 698972005301 dimer interface [polypeptide binding]; other site 698972005302 putative active site [active] 698972005303 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 698972005304 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 698972005305 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 698972005306 phosphoserine phosphatase SerB; Region: serB; TIGR00338 698972005307 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698972005308 motif II; other site 698972005309 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 698972005310 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 698972005311 D-pathway; other site 698972005312 Putative ubiquinol binding site [chemical binding]; other site 698972005313 Low-spin heme (heme b) binding site [chemical binding]; other site 698972005314 Putative water exit pathway; other site 698972005315 Binuclear center (heme o3/CuB) [ion binding]; other site 698972005316 K-pathway; other site 698972005317 Putative proton exit pathway; other site 698972005318 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698972005319 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698972005320 dimer interface [polypeptide binding]; other site 698972005321 putative radical transfer pathway; other site 698972005322 diiron center [ion binding]; other site 698972005323 tyrosyl radical; other site 698972005324 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 698972005325 Ferritin-like domain; Region: Ferritin; pfam00210 698972005326 ferroxidase diiron center [ion binding]; other site 698972005327 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 698972005328 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 698972005329 Class I ribonucleotide reductase; Region: RNR_I; cd01679 698972005330 active site 698972005331 dimer interface [polypeptide binding]; other site 698972005332 catalytic residues [active] 698972005333 effector binding site; other site 698972005334 R2 peptide binding site; other site 698972005335 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698972005336 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698972005337 catalytic residues [active] 698972005338 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 698972005339 active site lid residues [active] 698972005340 substrate binding pocket [chemical binding]; other site 698972005341 catalytic residues [active] 698972005342 substrate-Mg2+ binding site; other site 698972005343 aspartate-rich region 1; other site 698972005344 aspartate-rich region 2; other site 698972005345 phytoene desaturase; Region: crtI_fam; TIGR02734 698972005346 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698972005347 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 698972005348 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 698972005349 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 698972005350 homodimer interface [polypeptide binding]; other site 698972005351 NAD binding pocket [chemical binding]; other site 698972005352 ATP binding pocket [chemical binding]; other site 698972005353 Mg binding site [ion binding]; other site 698972005354 active-site loop [active] 698972005355 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 698972005356 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 698972005357 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 698972005358 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 698972005359 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 698972005360 Predicted transcriptional regulator [Transcription]; Region: COG2345 698972005361 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 698972005362 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698972005363 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 698972005364 catalytic residues [active] 698972005365 Methylamine utilisation protein MauE; Region: MauE; pfam07291 698972005366 phosphoglucomutase; Validated; Region: PRK07564 698972005367 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 698972005368 active site 698972005369 substrate binding site [chemical binding]; other site 698972005370 metal binding site [ion binding]; metal-binding site 698972005371 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK00134 698972005372 CrcB-like protein; Region: CRCB; pfam02537 698972005373 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698972005374 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698972005375 FtsX-like permease family; Region: FtsX; pfam02687 698972005376 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698972005377 FtsX-like permease family; Region: FtsX; pfam02687 698972005378 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698972005379 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698972005380 Walker A/P-loop; other site 698972005381 ATP binding site [chemical binding]; other site 698972005382 Q-loop/lid; other site 698972005383 ABC transporter signature motif; other site 698972005384 Walker B; other site 698972005385 D-loop; other site 698972005386 H-loop/switch region; other site 698972005387 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698972005388 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698972005389 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698972005390 hinge; other site 698972005391 active site 698972005392 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 698972005393 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 698972005394 GAF domain; Region: GAF_2; pfam13185 698972005395 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698972005396 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698972005397 DNA binding residues [nucleotide binding] 698972005398 dimerization interface [polypeptide binding]; other site 698972005399 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698972005400 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698972005401 dimer interface [polypeptide binding]; other site 698972005402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698972005403 catalytic residue [active] 698972005404 serine O-acetyltransferase; Region: cysE; TIGR01172 698972005405 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 698972005406 trimer interface [polypeptide binding]; other site 698972005407 active site 698972005408 substrate binding site [chemical binding]; other site 698972005409 CoA binding site [chemical binding]; other site 698972005410 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698972005411 Coenzyme A binding pocket [chemical binding]; other site 698972005412 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 698972005413 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 698972005414 putative active site [active] 698972005415 metal binding site [ion binding]; metal-binding site 698972005416 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 698972005417 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698972005418 Walker A/P-loop; other site 698972005419 ATP binding site [chemical binding]; other site 698972005420 Q-loop/lid; other site 698972005421 ABC transporter signature motif; other site 698972005422 Walker B; other site 698972005423 D-loop; other site 698972005424 H-loop/switch region; other site 698972005425 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 698972005426 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698972005427 intersubunit interface [polypeptide binding]; other site 698972005428 ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism]; Region: FepD; COG0609 698972005429 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698972005430 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698972005431 ABC-ATPase subunit interface; other site 698972005432 dimer interface [polypeptide binding]; other site 698972005433 putative PBP binding regions; other site 698972005434 HTH-like domain; Region: HTH_21; pfam13276 698972005435 Integrase core domain; Region: rve; pfam00665 698972005436 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 698972005437 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 698972005438 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698972005439 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698972005440 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 698972005441 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698972005442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972005443 Walker A/P-loop; other site 698972005444 ATP binding site [chemical binding]; other site 698972005445 Q-loop/lid; other site 698972005446 ABC transporter signature motif; other site 698972005447 Walker B; other site 698972005448 D-loop; other site 698972005449 H-loop/switch region; other site 698972005450 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 698972005451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972005452 Walker A/P-loop; other site 698972005453 ATP binding site [chemical binding]; other site 698972005454 Q-loop/lid; other site 698972005455 ABC transporter signature motif; other site 698972005456 Walker B; other site 698972005457 D-loop; other site 698972005458 H-loop/switch region; other site 698972005459 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 698972005460 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 698972005461 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 698972005462 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 698972005463 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 698972005464 FMN binding site [chemical binding]; other site 698972005465 active site 698972005466 catalytic residues [active] 698972005467 substrate binding site [chemical binding]; other site 698972005468 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 698972005469 PhoU domain; Region: PhoU; pfam01895 698972005470 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 698972005471 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698972005472 Coenzyme A binding pocket [chemical binding]; other site 698972005473 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698972005474 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698972005475 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 698972005476 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 698972005477 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 698972005478 heme-binding site [chemical binding]; other site 698972005479 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 698972005480 substrate binding site [chemical binding]; other site 698972005481 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 698972005482 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 698972005483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698972005484 catalytic residue [active] 698972005485 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 698972005486 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 698972005487 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698972005488 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 698972005489 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 698972005490 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 698972005491 dimerization interface [polypeptide binding]; other site 698972005492 putative ATP binding site [chemical binding]; other site 698972005493 amidophosphoribosyltransferase; Provisional; Region: PRK07847 698972005494 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 698972005495 active site 698972005496 tetramer interface [polypeptide binding]; other site 698972005497 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698972005498 active site 698972005499 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 698972005500 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 698972005501 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698972005502 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698972005503 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698972005504 dimer interface [polypeptide binding]; other site 698972005505 putative radical transfer pathway; other site 698972005506 diiron center [ion binding]; other site 698972005507 tyrosyl radical; other site 698972005508 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 698972005509 catalytic residues [active] 698972005510 dimer interface [polypeptide binding]; other site 698972005511 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 698972005512 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698972005513 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 698972005514 ATP binding site [chemical binding]; other site 698972005515 active site 698972005516 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 698972005517 substrate binding site [chemical binding]; other site 698972005518 adenylosuccinate lyase; Region: purB; TIGR00928 698972005519 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 698972005520 tetramer interface [polypeptide binding]; other site 698972005521 aspartate aminotransferase; Provisional; Region: PRK05764 698972005522 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698972005523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698972005524 homodimer interface [polypeptide binding]; other site 698972005525 catalytic residue [active] 698972005526 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 698972005527 TrkA-N domain; Region: TrkA_N; pfam02254 698972005528 TrkA-C domain; Region: TrkA_C; pfam02080 698972005529 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 698972005530 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 698972005531 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 698972005532 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 698972005533 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 698972005534 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 698972005535 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 698972005536 nucleotide binding site/active site [active] 698972005537 HIT family signature motif; other site 698972005538 catalytic residue [active] 698972005539 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 698972005540 PGAP1-like protein; Region: PGAP1; pfam07819 698972005541 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698972005542 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698972005543 dimerization interface [polypeptide binding]; other site 698972005544 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698972005545 dimer interface [polypeptide binding]; other site 698972005546 phosphorylation site [posttranslational modification] 698972005547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698972005548 ATP binding site [chemical binding]; other site 698972005549 Mg2+ binding site [ion binding]; other site 698972005550 G-X-G motif; other site 698972005551 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698972005552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698972005553 active site 698972005554 phosphorylation site [posttranslational modification] 698972005555 intermolecular recognition site; other site 698972005556 dimerization interface [polypeptide binding]; other site 698972005557 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698972005558 DNA binding site [nucleotide binding] 698972005559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972005560 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698972005561 putative substrate translocation pore; other site 698972005562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972005563 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698972005564 xanthine permease; Region: pbuX; TIGR03173 698972005565 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 698972005566 pyruvate dehydrogenase; Provisional; Region: PRK06546 698972005567 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 698972005568 PYR/PP interface [polypeptide binding]; other site 698972005569 dimer interface [polypeptide binding]; other site 698972005570 tetramer interface [polypeptide binding]; other site 698972005571 TPP binding site [chemical binding]; other site 698972005572 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698972005573 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 698972005574 TPP-binding site [chemical binding]; other site 698972005575 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698972005576 Uncharacterized conserved protein [Function unknown]; Region: COG3610 698972005577 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698972005578 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698972005579 Uncharacterized conserved protein [Function unknown]; Region: COG3610 698972005580 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 698972005581 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 698972005582 active site 698972005583 homotetramer interface [polypeptide binding]; other site 698972005584 META domain; Region: META; cl01245 698972005585 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 698972005586 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 698972005587 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698972005588 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698972005589 DNA binding site [nucleotide binding] 698972005590 domain linker motif; other site 698972005591 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 698972005592 putative dimerization interface [polypeptide binding]; other site 698972005593 putative ligand binding site [chemical binding]; other site 698972005594 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698972005595 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 698972005596 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698972005597 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 698972005598 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698972005599 active site 698972005600 HIGH motif; other site 698972005601 nucleotide binding site [chemical binding]; other site 698972005602 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698972005603 KMSKS motif; other site 698972005604 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698972005605 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 698972005606 homotrimer interaction site [polypeptide binding]; other site 698972005607 zinc binding site [ion binding]; other site 698972005608 CDP-binding sites; other site 698972005609 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 698972005610 substrate binding site; other site 698972005611 dimer interface; other site 698972005612 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 698972005613 DNA repair protein RadA; Provisional; Region: PRK11823 698972005614 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698972005615 Walker A motif; other site 698972005616 ATP binding site [chemical binding]; other site 698972005617 Walker B motif; other site 698972005618 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698972005619 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 698972005620 active site clefts [active] 698972005621 zinc binding site [ion binding]; other site 698972005622 dimer interface [polypeptide binding]; other site 698972005623 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698972005624 endonuclease III; Region: ENDO3c; smart00478 698972005625 minor groove reading motif; other site 698972005626 helix-hairpin-helix signature motif; other site 698972005627 substrate binding pocket [chemical binding]; other site 698972005628 active site 698972005629 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698972005630 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698972005631 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 698972005632 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 698972005633 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 698972005634 Clp amino terminal domain; Region: Clp_N; pfam02861 698972005635 Clp amino terminal domain; Region: Clp_N; pfam02861 698972005636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698972005637 Walker A motif; other site 698972005638 ATP binding site [chemical binding]; other site 698972005639 Walker B motif; other site 698972005640 arginine finger; other site 698972005641 UvrB/uvrC motif; Region: UVR; pfam02151 698972005642 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698972005643 Walker A motif; other site 698972005644 ATP binding site [chemical binding]; other site 698972005645 Walker B motif; other site 698972005646 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698972005647 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 698972005648 oligomer interface [polypeptide binding]; other site 698972005649 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698972005650 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698972005651 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 698972005652 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 698972005653 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698972005654 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698972005655 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 698972005656 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 698972005657 active site 698972005658 catalytic motif [active] 698972005659 Zn binding site [ion binding]; other site 698972005660 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 698972005661 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 698972005662 Nucleoside recognition; Region: Gate; pfam07670 698972005663 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 698972005664 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 698972005665 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698972005666 dimer interface [polypeptide binding]; other site 698972005667 putative anticodon binding site; other site 698972005668 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698972005669 motif 1; other site 698972005670 dimer interface [polypeptide binding]; other site 698972005671 active site 698972005672 motif 2; other site 698972005673 motif 3; other site 698972005674 YcaO-like family; Region: YcaO; pfam02624 698972005675 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 698972005676 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 698972005677 NADPH bind site [chemical binding]; other site 698972005678 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 698972005679 dimer interface [polypeptide binding]; other site 698972005680 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 698972005681 SpaB C-terminal domain; Region: SpaB_C; pfam14028 698972005682 YcaO-like family; Region: YcaO; pfam02624 698972005683 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 698972005684 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698972005685 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698972005686 Walker A/P-loop; other site 698972005687 ATP binding site [chemical binding]; other site 698972005688 Q-loop/lid; other site 698972005689 ABC transporter signature motif; other site 698972005690 Walker B; other site 698972005691 D-loop; other site 698972005692 H-loop/switch region; other site 698972005693 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698972005694 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 698972005695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 698972005696 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698972005697 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698972005698 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698972005699 pantoate--beta-alanine ligase; Region: panC; TIGR00018 698972005700 active site 698972005701 nucleotide binding site [chemical binding]; other site 698972005702 HIGH motif; other site 698972005703 KMSKS motif; other site 698972005704 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 698972005705 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 698972005706 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 698972005707 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 698972005708 catalytic center binding site [active] 698972005709 ATP binding site [chemical binding]; other site 698972005710 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 698972005711 homooctamer interface [polypeptide binding]; other site 698972005712 active site 698972005713 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698972005714 dihydropteroate synthase; Region: DHPS; TIGR01496 698972005715 substrate binding pocket [chemical binding]; other site 698972005716 dimer interface [polypeptide binding]; other site 698972005717 inhibitor binding site; inhibition site 698972005718 Protein of unknown function, DUF393; Region: DUF393; pfam04134 698972005719 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 698972005720 homodecamer interface [polypeptide binding]; other site 698972005721 GTP cyclohydrolase I; Provisional; Region: PLN03044 698972005722 active site 698972005723 putative catalytic site residues [active] 698972005724 zinc binding site [ion binding]; other site 698972005725 GTP-CH-I/GFRP interaction surface; other site 698972005726 FtsH Extracellular; Region: FtsH_ext; pfam06480 698972005727 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 698972005728 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698972005729 Walker A motif; other site 698972005730 ATP binding site [chemical binding]; other site 698972005731 Walker B motif; other site 698972005732 arginine finger; other site 698972005733 Peptidase family M41; Region: Peptidase_M41; pfam01434 698972005734 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698972005735 active site 698972005736 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 698972005737 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 698972005738 Ligand Binding Site [chemical binding]; other site 698972005739 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 698972005740 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 698972005741 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 698972005742 dimer interface [polypeptide binding]; other site 698972005743 substrate binding site [chemical binding]; other site 698972005744 metal binding sites [ion binding]; metal-binding site 698972005745 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698972005746 active site residue [active] 698972005747 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698972005748 MarR family; Region: MarR_2; pfam12802 698972005749 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698972005750 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 698972005751 acyl-activating enzyme (AAE) consensus motif; other site 698972005752 AMP binding site [chemical binding]; other site 698972005753 active site 698972005754 CoA binding site [chemical binding]; other site 698972005755 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698972005756 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 698972005757 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698972005758 putative trimer interface [polypeptide binding]; other site 698972005759 putative CoA binding site [chemical binding]; other site 698972005760 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698972005761 putative trimer interface [polypeptide binding]; other site 698972005762 putative CoA binding site [chemical binding]; other site 698972005763 potential frameshift: common BLAST hit: gi|38234579|ref|NP_940346.1| exported lipase 698972005764 Secretory lipase; Region: LIP; pfam03583 698972005765 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698972005766 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 698972005767 active site 698972005768 catalytic triad [active] 698972005769 oxyanion hole [active] 698972005770 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698972005771 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698972005772 ring oligomerisation interface [polypeptide binding]; other site 698972005773 ATP/Mg binding site [chemical binding]; other site 698972005774 stacking interactions; other site 698972005775 hinge regions; other site 698972005776 Fic/DOC family; Region: Fic; pfam02661 698972005777 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 698972005778 hypothetical protein; Reviewed; Region: PRK09588 698972005779 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698972005780 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698972005781 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 698972005782 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 698972005783 Probable pectinesterase/pectinesterase inhibitor; Region: PLN02698 698972005784 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 698972005785 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698972005786 HTH-like domain; Region: HTH_21; pfam13276 698972005787 Integrase core domain; Region: rve; pfam00665 698972005788 Integrase core domain; Region: rve_2; pfam13333 698972005789 MULE transposase domain; Region: MULE; pfam10551 698972005790 hypothetical protein; Provisional; Region: PRK07907 698972005791 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 698972005792 active site 698972005793 metal binding site [ion binding]; metal-binding site 698972005794 dimer interface [polypeptide binding]; other site 698972005795 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698972005796 carboxylate-amine ligase; Provisional; Region: PRK13517 698972005797 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 698972005798 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698972005799 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698972005800 active site 698972005801 catalytic residues [active] 698972005802 metal binding site [ion binding]; metal-binding site 698972005803 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698972005804 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698972005805 Coenzyme A binding pocket [chemical binding]; other site 698972005806 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698972005807 putative catalytic site [active] 698972005808 putative metal binding site [ion binding]; other site 698972005809 putative phosphate binding site [ion binding]; other site 698972005810 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 698972005811 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 698972005812 putative active site [active] 698972005813 catalytic site [active] 698972005814 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 698972005815 putative active site [active] 698972005816 catalytic site [active] 698972005817 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698972005818 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698972005819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972005820 Walker A/P-loop; other site 698972005821 ATP binding site [chemical binding]; other site 698972005822 Q-loop/lid; other site 698972005823 ABC transporter signature motif; other site 698972005824 Walker B; other site 698972005825 D-loop; other site 698972005826 H-loop/switch region; other site 698972005827 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698972005828 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698972005829 substrate binding pocket [chemical binding]; other site 698972005830 membrane-bound complex binding site; other site 698972005831 hinge residues; other site 698972005832 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698972005833 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698972005834 active site 698972005835 ATP binding site [chemical binding]; other site 698972005836 substrate binding site [chemical binding]; other site 698972005837 activation loop (A-loop); other site 698972005838 propionate/acetate kinase; Provisional; Region: PRK12379 698972005839 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 698972005840 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 698972005841 ferredoxin-NADP+ reductase; Region: PLN02852 698972005842 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698972005843 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698972005844 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 698972005845 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698972005846 active site 698972005847 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698972005848 putative active site [active] 698972005849 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 698972005850 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 698972005851 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 698972005852 GDP-binding site [chemical binding]; other site 698972005853 ACT binding site; other site 698972005854 IMP binding site; other site 698972005855 Predicted membrane protein [Function unknown]; Region: COG4129 698972005856 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698972005857 chromosome segregation protein; Provisional; Region: PRK03918 698972005858 Predicted membrane protein [Function unknown]; Region: COG4129 698972005859 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698972005860 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 698972005861 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698972005862 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 698972005863 Integrase core domain; Region: rve_3; pfam13683 698972005864 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 698972005865 catalytic nucleophile [active] 698972005866 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 698972005867 YfbU domain; Region: YfbU; cl01137 698972005868 YfbU domain; Region: YfbU; cl01137 698972005869 Abi-like protein; Region: Abi_2; pfam07751 698972005870 Integrase core domain; Region: rve_2; pfam13333 698972005871 potential frameshift: common BLAST hit: gi|30387231|ref|NP_848207.1| TnpB 698972005872 Integrase core domain; Region: rve; pfam00665 698972005873 HTH-like domain; Region: HTH_21; pfam13276 698972005874 TQXA domain; Region: TQXA_dom; TIGR03934 698972005875 Integrase core domain; Region: rve; pfam00665 698972005876 Integrase core domain; Region: rve_2; pfam13333 698972005877 Winged helix-turn helix; Region: HTH_29; pfam13551 698972005878 Helix-turn-helix domain; Region: HTH_28; pfam13518 698972005879 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 698972005880 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 698972005881 active site 698972005882 intersubunit interface [polypeptide binding]; other site 698972005883 zinc binding site [ion binding]; other site 698972005884 Na+ binding site [ion binding]; other site 698972005885 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 698972005886 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698972005887 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698972005888 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698972005889 active site 698972005890 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698972005891 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698972005892 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698972005893 active site residue [active] 698972005894 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698972005895 active site residue [active] 698972005896 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 698972005897 Clp amino terminal domain; Region: Clp_N; pfam02861 698972005898 Clp amino terminal domain; Region: Clp_N; pfam02861 698972005899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698972005900 Walker A motif; other site 698972005901 ATP binding site [chemical binding]; other site 698972005902 Walker B motif; other site 698972005903 arginine finger; other site 698972005904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698972005905 Walker A motif; other site 698972005906 ATP binding site [chemical binding]; other site 698972005907 Walker B motif; other site 698972005908 arginine finger; other site 698972005909 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698972005910 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 698972005911 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 698972005912 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698972005913 Walker A/P-loop; other site 698972005914 ATP binding site [chemical binding]; other site 698972005915 Q-loop/lid; other site 698972005916 ABC transporter signature motif; other site 698972005917 Walker B; other site 698972005918 D-loop; other site 698972005919 H-loop/switch region; other site 698972005920 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698972005921 EamA-like transporter family; Region: EamA; pfam00892 698972005922 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698972005923 EamA-like transporter family; Region: EamA; pfam00892 698972005924 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 698972005925 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 698972005926 FAD binding pocket [chemical binding]; other site 698972005927 FAD binding motif [chemical binding]; other site 698972005928 phosphate binding motif [ion binding]; other site 698972005929 beta-alpha-beta structure motif; other site 698972005930 NAD binding pocket [chemical binding]; other site 698972005931 Predicted amidohydrolase [General function prediction only]; Region: COG0388 698972005932 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 698972005933 putative active site [active] 698972005934 catalytic triad [active] 698972005935 putative dimer interface [polypeptide binding]; other site 698972005936 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 698972005937 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 698972005938 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 698972005939 NAD binding site [chemical binding]; other site 698972005940 substrate binding site [chemical binding]; other site 698972005941 catalytic Zn binding site [ion binding]; other site 698972005942 tetramer interface [polypeptide binding]; other site 698972005943 structural Zn binding site [ion binding]; other site 698972005944 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698972005945 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698972005946 NAD(P) binding site [chemical binding]; other site 698972005947 catalytic residues [active] 698972005948 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 698972005949 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 698972005950 DNA binding residues [nucleotide binding] 698972005951 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698972005952 putative dimer interface [polypeptide binding]; other site 698972005953 chaperone protein DnaJ; Provisional; Region: PRK14279 698972005954 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698972005955 HSP70 interaction site [polypeptide binding]; other site 698972005956 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698972005957 Zn binding sites [ion binding]; other site 698972005958 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698972005959 dimer interface [polypeptide binding]; other site 698972005960 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 698972005961 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 698972005962 dimer interface [polypeptide binding]; other site 698972005963 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 698972005964 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 698972005965 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 698972005966 nucleotide binding site [chemical binding]; other site 698972005967 NEF interaction site [polypeptide binding]; other site 698972005968 SBD interface [polypeptide binding]; other site 698972005969 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698972005970 PAS domain; Region: PAS_9; pfam13426 698972005971 putative active site [active] 698972005972 heme pocket [chemical binding]; other site 698972005973 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698972005974 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698972005975 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698972005976 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 698972005977 Walker A/P-loop; other site 698972005978 ATP binding site [chemical binding]; other site 698972005979 Q-loop/lid; other site 698972005980 ABC transporter signature motif; other site 698972005981 Walker B; other site 698972005982 D-loop; other site 698972005983 H-loop/switch region; other site 698972005984 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698972005985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698972005986 dimer interface [polypeptide binding]; other site 698972005987 conserved gate region; other site 698972005988 putative PBP binding loops; other site 698972005989 ABC-ATPase subunit interface; other site 698972005990 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698972005991 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 698972005992 Walker A/P-loop; other site 698972005993 ATP binding site [chemical binding]; other site 698972005994 Q-loop/lid; other site 698972005995 ABC transporter signature motif; other site 698972005996 Walker B; other site 698972005997 D-loop; other site 698972005998 H-loop/switch region; other site 698972005999 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698972006000 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698972006001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698972006002 dimer interface [polypeptide binding]; other site 698972006003 conserved gate region; other site 698972006004 putative PBP binding loops; other site 698972006005 ABC-ATPase subunit interface; other site 698972006006 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698972006007 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 698972006008 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698972006009 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698972006010 aminotransferase; Validated; Region: PRK07777 698972006011 ferredoxin-NADP+ reductase; Region: PLN02852 698972006012 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 698972006013 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 698972006014 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 698972006015 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 698972006016 dimerization interface [polypeptide binding]; other site 698972006017 ATP binding site [chemical binding]; other site 698972006018 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 698972006019 dimerization interface [polypeptide binding]; other site 698972006020 ATP binding site [chemical binding]; other site 698972006021 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 698972006022 putative active site [active] 698972006023 catalytic triad [active] 698972006024 potential frameshift: common BLAST hit: gi|172039859|ref|YP_001799573.1| acetyl-CoA acetyltransferase 698972006025 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 698972006026 active site 698972006027 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698972006028 substrate binding site [chemical binding]; other site 698972006029 oxyanion hole (OAH) forming residues; other site 698972006030 trimer interface [polypeptide binding]; other site 698972006031 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 698972006032 active site 698972006033 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 698972006034 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 698972006035 FAD binding pocket [chemical binding]; other site 698972006036 FAD binding motif [chemical binding]; other site 698972006037 phosphate binding motif [ion binding]; other site 698972006038 NAD binding pocket [chemical binding]; other site 698972006039 Siderophore-interacting protein; Region: SIP; pfam04954 698972006040 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698972006041 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698972006042 Walker A/P-loop; other site 698972006043 ATP binding site [chemical binding]; other site 698972006044 Q-loop/lid; other site 698972006045 ABC transporter signature motif; other site 698972006046 Walker B; other site 698972006047 D-loop; other site 698972006048 H-loop/switch region; other site 698972006049 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698972006050 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698972006051 ABC-ATPase subunit interface; other site 698972006052 dimer interface [polypeptide binding]; other site 698972006053 putative PBP binding regions; other site 698972006054 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698972006055 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698972006056 ABC-ATPase subunit interface; other site 698972006057 dimer interface [polypeptide binding]; other site 698972006058 putative PBP binding regions; other site 698972006059 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 698972006060 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698972006061 siderophore binding site; other site 698972006062 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 698972006063 ferredoxin-NADP+ reductase; Region: PLN02852 698972006064 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698972006065 4Fe-4S binding domain; Region: Fer4; cl02805 698972006066 Cysteine-rich domain; Region: CCG; pfam02754 698972006067 Cysteine-rich domain; Region: CCG; pfam02754 698972006068 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 698972006069 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698972006070 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 698972006071 putative NAD(P) binding site [chemical binding]; other site 698972006072 catalytic Zn binding site [ion binding]; other site 698972006073 aminotransferase AlaT; Validated; Region: PRK09265 698972006074 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698972006075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698972006076 homodimer interface [polypeptide binding]; other site 698972006077 catalytic residue [active] 698972006078 YibE/F-like protein; Region: YibE_F; pfam07907 698972006079 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 698972006080 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 698972006081 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698972006082 dimer interface [polypeptide binding]; other site 698972006083 putative anticodon binding site; other site 698972006084 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698972006085 motif 1; other site 698972006086 dimer interface [polypeptide binding]; other site 698972006087 active site 698972006088 motif 2; other site 698972006089 motif 3; other site 698972006090 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698972006091 Protein of unknown function (DUF998); Region: DUF998; pfam06197 698972006092 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 698972006093 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 698972006094 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 698972006095 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698972006096 trimer interface [polypeptide binding]; other site 698972006097 active site 698972006098 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698972006099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972006100 Walker A/P-loop; other site 698972006101 ATP binding site [chemical binding]; other site 698972006102 Q-loop/lid; other site 698972006103 ABC transporter signature motif; other site 698972006104 Walker B; other site 698972006105 D-loop; other site 698972006106 H-loop/switch region; other site 698972006107 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 698972006108 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698972006109 active site 698972006110 potential frameshift: common BLAST hit: gi|38234699|ref|NP_940466.1| DNA-binding bacteriophage protein 698972006111 BRO family, N-terminal domain; Region: Bro-N; smart01040 698972006112 Abi-like protein; Region: Abi_2; cl01988 698972006113 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 698972006114 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698972006115 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698972006116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972006117 Walker A/P-loop; other site 698972006118 ATP binding site [chemical binding]; other site 698972006119 Q-loop/lid; other site 698972006120 ABC transporter signature motif; other site 698972006121 Walker B; other site 698972006122 D-loop; other site 698972006123 H-loop/switch region; other site 698972006124 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698972006125 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698972006126 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972006127 Walker A/P-loop; other site 698972006128 ATP binding site [chemical binding]; other site 698972006129 Q-loop/lid; other site 698972006130 ABC transporter signature motif; other site 698972006131 Walker B; other site 698972006132 D-loop; other site 698972006133 H-loop/switch region; other site 698972006134 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698972006135 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 698972006136 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698972006137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698972006138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698972006139 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698972006140 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 698972006141 Walker A/P-loop; other site 698972006142 ATP binding site [chemical binding]; other site 698972006143 Q-loop/lid; other site 698972006144 ABC transporter signature motif; other site 698972006145 Walker B; other site 698972006146 D-loop; other site 698972006147 H-loop/switch region; other site 698972006148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972006149 Walker A/P-loop; other site 698972006150 ATP binding site [chemical binding]; other site 698972006151 Q-loop/lid; other site 698972006152 ABC transporter signature motif; other site 698972006153 Walker B; other site 698972006154 D-loop; other site 698972006155 H-loop/switch region; other site 698972006156 metabolite-proton symporter; Region: 2A0106; TIGR00883 698972006157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972006158 putative substrate translocation pore; other site 698972006159 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698972006160 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698972006161 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 698972006162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972006163 putative substrate translocation pore; other site 698972006164 YwiC-like protein; Region: YwiC; pfam14256 698972006165 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698972006166 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698972006167 VanW like protein; Region: VanW; pfam04294 698972006168 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 698972006169 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 698972006170 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 698972006171 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698972006172 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698972006173 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698972006174 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698972006175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698972006176 S-adenosylmethionine binding site [chemical binding]; other site 698972006177 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 698972006178 active site 698972006179 substrate-binding site [chemical binding]; other site 698972006180 metal-binding site [ion binding] 698972006181 GTP binding site [chemical binding]; other site 698972006182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698972006183 S-adenosylmethionine binding site [chemical binding]; other site 698972006184 LabA_like proteins; Region: LabA_like; cd06167 698972006185 putative metal binding site [ion binding]; other site 698972006186 MMPL family; Region: MMPL; pfam03176 698972006187 MMPL family; Region: MMPL; pfam03176 698972006188 Predicted integral membrane protein [Function unknown]; Region: COG0392 698972006189 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 698972006190 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 698972006191 TQXA domain; Region: TQXA_dom; TIGR03934 698972006192 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 698972006193 active site 698972006194 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698972006195 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698972006196 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698972006197 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698972006198 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 698972006199 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 698972006200 active site 698972006201 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 698972006202 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 698972006203 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 698972006204 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 698972006205 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 698972006206 acyl-activating enzyme (AAE) consensus motif; other site 698972006207 active site 698972006208 Cutinase; Region: Cutinase; pfam01083 698972006209 Putative esterase; Region: Esterase; pfam00756 698972006210 S-formylglutathione hydrolase; Region: PLN02442 698972006211 LGFP repeat; Region: LGFP; pfam08310 698972006212 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698972006213 LGFP repeat; Region: LGFP; pfam08310 698972006214 LGFP repeat; Region: LGFP; pfam08310 698972006215 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 698972006216 Homeodomain-like domain; Region: HTH_23; cl17451 698972006217 Helix-turn-helix domain; Region: HTH_28; pfam13518 698972006218 putative transposase OrfB; Reviewed; Region: PHA02517 698972006219 HTH-like domain; Region: HTH_21; pfam13276 698972006220 Integrase core domain; Region: rve; pfam00665 698972006221 Integrase core domain; Region: rve_2; pfam13333 698972006222 Predicted esterase [General function prediction only]; Region: COG0627 698972006223 S-formylglutathione hydrolase; Region: PLN02442 698972006224 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 698972006225 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 698972006226 UbiA prenyltransferase family; Region: UbiA; pfam01040 698972006227 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698972006228 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698972006229 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698972006230 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698972006231 active site 698972006232 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698972006233 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698972006234 NAD(P) binding site [chemical binding]; other site 698972006235 catalytic residues [active] 698972006236 BCCT family transporter; Region: BCCT; cl00569 698972006237 choline dehydrogenase; Validated; Region: PRK02106 698972006238 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698972006239 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 698972006240 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698972006241 UDP-galactopyranose mutase; Region: GLF; pfam03275 698972006242 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 698972006243 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 698972006244 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698972006245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972006246 ABC transporter signature motif; other site 698972006247 Walker B; other site 698972006248 D-loop; other site 698972006249 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698972006250 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698972006251 amidase catalytic site [active] 698972006252 Zn binding residues [ion binding]; other site 698972006253 substrate binding site [chemical binding]; other site 698972006254 LGFP repeat; Region: LGFP; pfam08310 698972006255 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 698972006256 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698972006257 RloB-like protein; Region: RloB; pfam13707 698972006258 Predicted ATPases [General function prediction only]; Region: COG1106 698972006259 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972006260 Q-loop/lid; other site 698972006261 ABC transporter signature motif; other site 698972006262 Walker B; other site 698972006263 D-loop; other site 698972006264 H-loop/switch region; other site 698972006265 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698972006266 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698972006267 Walker A/P-loop; other site 698972006268 ATP binding site [chemical binding]; other site 698972006269 Q-loop/lid; other site 698972006270 ABC transporter signature motif; other site 698972006271 Walker B; other site 698972006272 D-loop; other site 698972006273 H-loop/switch region; other site 698972006274 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698972006275 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698972006276 siderophore binding site; other site 698972006277 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698972006278 ABC-ATPase subunit interface; other site 698972006279 dimer interface [polypeptide binding]; other site 698972006280 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698972006281 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698972006282 putative PBP binding regions; other site 698972006283 ABC-ATPase subunit interface; other site 698972006284 glycerol kinase; Provisional; Region: glpK; PRK00047 698972006285 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 698972006286 N- and C-terminal domain interface [polypeptide binding]; other site 698972006287 active site 698972006288 MgATP binding site [chemical binding]; other site 698972006289 catalytic site [active] 698972006290 metal binding site [ion binding]; metal-binding site 698972006291 putative homotetramer interface [polypeptide binding]; other site 698972006292 glycerol binding site [chemical binding]; other site 698972006293 homodimer interface [polypeptide binding]; other site 698972006294 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 698972006295 amphipathic channel; other site 698972006296 Asn-Pro-Ala signature motifs; other site 698972006297 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 698972006298 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698972006299 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698972006300 putative acyl-acceptor binding pocket; other site 698972006301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698972006302 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698972006303 active site 698972006304 motif I; other site 698972006305 motif II; other site 698972006306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698972006307 seryl-tRNA synthetase; Provisional; Region: PRK05431 698972006308 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 698972006309 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 698972006310 dimer interface [polypeptide binding]; other site 698972006311 active site 698972006312 motif 1; other site 698972006313 motif 2; other site 698972006314 motif 3; other site 698972006315 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698972006316 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698972006317 DNA-binding site [nucleotide binding]; DNA binding site 698972006318 UTRA domain; Region: UTRA; pfam07702 698972006319 Septum formation; Region: Septum_form; pfam13845 698972006320 Septum formation; Region: Septum_form; pfam13845 698972006321 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 698972006322 AAA domain; Region: AAA_14; pfam13173 698972006323 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 698972006324 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698972006325 catalytic core [active] 698972006326 prephenate dehydratase; Provisional; Region: PRK11898 698972006327 Prephenate dehydratase; Region: PDT; pfam00800 698972006328 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 698972006329 putative L-Phe binding site [chemical binding]; other site 698972006330 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698972006331 Amidase; Region: Amidase; cl11426 698972006332 CAAX protease self-immunity; Region: Abi; pfam02517 698972006333 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 698972006334 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698972006335 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698972006336 amino acid carrier protein; Region: agcS; TIGR00835 698972006337 Acyltransferase family; Region: Acyl_transf_3; pfam01757 698972006338 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 698972006339 catalytic triad [active] 698972006340 catalytic triad [active] 698972006341 oxyanion hole [active] 698972006342 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698972006343 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 698972006344 putative active site [active] 698972006345 catalytic site [active] 698972006346 putative metal binding site [ion binding]; other site 698972006347 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 698972006348 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 698972006349 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698972006350 NAD binding site [chemical binding]; other site 698972006351 dimer interface [polypeptide binding]; other site 698972006352 substrate binding site [chemical binding]; other site 698972006353 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 698972006354 nudix motif; other site 698972006355 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 698972006356 quinolinate synthetase; Provisional; Region: PRK09375 698972006357 L-aspartate oxidase; Provisional; Region: PRK06175 698972006358 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 698972006359 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 698972006360 dimerization interface [polypeptide binding]; other site 698972006361 active site 698972006362 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 698972006363 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 698972006364 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 698972006365 Predicted flavoprotein [General function prediction only]; Region: COG0431 698972006366 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698972006367 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 698972006368 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 698972006369 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698972006370 Lsr2; Region: Lsr2; pfam11774 698972006371 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698972006372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698972006373 active site 698972006374 phosphorylation site [posttranslational modification] 698972006375 intermolecular recognition site; other site 698972006376 dimerization interface [polypeptide binding]; other site 698972006377 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698972006378 DNA binding residues [nucleotide binding] 698972006379 dimerization interface [polypeptide binding]; other site 698972006380 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698972006381 Histidine kinase; Region: HisKA_3; pfam07730 698972006382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698972006383 ATP binding site [chemical binding]; other site 698972006384 Mg2+ binding site [ion binding]; other site 698972006385 G-X-G motif; other site 698972006386 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 698972006387 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 698972006388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972006389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972006390 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 698972006391 active site 698972006392 catalytic site [active] 698972006393 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 698972006394 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 698972006395 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698972006396 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698972006397 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698972006398 Ligand Binding Site [chemical binding]; other site 698972006399 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698972006400 Ligand Binding Site [chemical binding]; other site 698972006401 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 698972006402 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698972006403 probable active site [active] 698972006404 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698972006405 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972006406 Walker A/P-loop; other site 698972006407 ATP binding site [chemical binding]; other site 698972006408 Q-loop/lid; other site 698972006409 ABC transporter signature motif; other site 698972006410 Walker B; other site 698972006411 D-loop; other site 698972006412 H-loop/switch region; other site 698972006413 Predicted transcriptional regulators [Transcription]; Region: COG1725 698972006414 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698972006415 DNA-binding site [nucleotide binding]; DNA binding site 698972006416 LabA_like proteins; Region: LabA_like; cd06167 698972006417 putative metal binding site [ion binding]; other site 698972006418 Uncharacterized conserved protein [Function unknown]; Region: COG1432 698972006419 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698972006420 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698972006421 catalytic residues [active] 698972006422 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698972006423 metal-binding site [ion binding] 698972006424 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698972006425 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698972006426 metal-binding site [ion binding] 698972006427 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698972006428 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698972006429 benzoate transport; Region: 2A0115; TIGR00895 698972006430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972006431 putative substrate translocation pore; other site 698972006432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698972006433 replicative DNA helicase; Provisional; Region: PRK05636 698972006434 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 698972006435 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 698972006436 Walker A motif; other site 698972006437 ATP binding site [chemical binding]; other site 698972006438 Walker B motif; other site 698972006439 DNA binding loops [nucleotide binding] 698972006440 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 698972006441 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 698972006442 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 698972006443 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698972006444 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698972006445 dimer interface [polypeptide binding]; other site 698972006446 ssDNA binding site [nucleotide binding]; other site 698972006447 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698972006448 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 698972006449 Predicted integral membrane protein [Function unknown]; Region: COG5650 698972006450 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698972006451 Transglycosylase; Region: Transgly; pfam00912 698972006452 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698972006453 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 698972006454 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698972006455 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698972006456 Ligand Binding Site [chemical binding]; other site 698972006457 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698972006458 Ligand Binding Site [chemical binding]; other site 698972006459 classical (c) SDRs; Region: SDR_c; cd05233 698972006460 short chain dehydrogenase; Provisional; Region: PRK08219 698972006461 NAD(P) binding site [chemical binding]; other site 698972006462 active site 698972006463 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698972006464 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698972006465 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 698972006466 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 698972006467 active site residue [active] 698972006468 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 698972006469 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698972006470 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 698972006471 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 698972006472 dimerization interface [polypeptide binding]; other site 698972006473 DPS ferroxidase diiron center [ion binding]; other site 698972006474 ion pore; other site 698972006475 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698972006476 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 698972006477 putative DNA binding site [nucleotide binding]; other site 698972006478 catalytic residue [active] 698972006479 putative H2TH interface [polypeptide binding]; other site 698972006480 putative catalytic residues [active] 698972006481 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698972006482 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698972006483 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 698972006484 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 698972006485 putative substrate binding site [chemical binding]; other site 698972006486 putative ATP binding site [chemical binding]; other site 698972006487 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 698972006488 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 698972006489 active site 698972006490 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698972006491 AAA domain; Region: AAA_31; pfam13614 698972006492 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698972006493 P-loop; other site 698972006494 Magnesium ion binding site [ion binding]; other site 698972006495 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698972006496 Magnesium ion binding site [ion binding]; other site 698972006497 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 698972006498 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 698972006499 putative ligand binding residues [chemical binding]; other site 698972006500 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698972006501 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698972006502 ABC-ATPase subunit interface; other site 698972006503 dimer interface [polypeptide binding]; other site 698972006504 putative PBP binding regions; other site 698972006505 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698972006506 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698972006507 Walker A/P-loop; other site 698972006508 ATP binding site [chemical binding]; other site 698972006509 Q-loop/lid; other site 698972006510 ABC transporter signature motif; other site 698972006511 Walker B; other site 698972006512 D-loop; other site 698972006513 H-loop/switch region; other site 698972006514 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 698972006515 dimer interface [polypeptide binding]; other site 698972006516 [2Fe-2S] cluster binding site [ion binding]; other site 698972006517 potential frameshift: common BLAST hit: gi|38234844|ref|NP_940611.1| DNA-binding protein 698972006518 MarR family; Region: MarR_2; cl17246 698972006519 Divergent AAA domain; Region: AAA_4; pfam04326 698972006520 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698972006521 Divergent AAA domain; Region: AAA_4; pfam04326 698972006522 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698972006523 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698972006524 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 698972006525 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698972006526 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698972006527 ATP binding site [chemical binding]; other site 698972006528 putative Mg++ binding site [ion binding]; other site 698972006529 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 698972006530 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698972006531 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 698972006532 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698972006533 potential frameshift: common BLAST hit: gi|38234849|ref|NP_940616.1| type I restriction/modification system DNA methylase 698972006534 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 698972006535 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698972006536 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698972006537 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698972006538 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 698972006539 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698972006540 HsdM N-terminal domain; Region: HsdM_N; pfam12161 698972006541 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 698972006542 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698972006543 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 698972006544 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698972006545 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 698972006546 DNA binding residues [nucleotide binding] 698972006547 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 698972006548 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 698972006549 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 698972006550 Uncharacterized conserved protein [Function unknown]; Region: COG3410 698972006551 Fic family protein [Function unknown]; Region: COG3177 698972006552 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698972006553 Fic/DOC family; Region: Fic; pfam02661 698972006554 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 698972006555 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 698972006556 E-class dimer interface [polypeptide binding]; other site 698972006557 P-class dimer interface [polypeptide binding]; other site 698972006558 active site 698972006559 Cu2+ binding site [ion binding]; other site 698972006560 Zn2+ binding site [ion binding]; other site 698972006561 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 698972006562 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698972006563 active site 698972006564 HIGH motif; other site 698972006565 nucleotide binding site [chemical binding]; other site 698972006566 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698972006567 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698972006568 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698972006569 active site 698972006570 KMSKS motif; other site 698972006571 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 698972006572 tRNA binding surface [nucleotide binding]; other site 698972006573 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698972006574 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698972006575 Walker A/P-loop; other site 698972006576 ATP binding site [chemical binding]; other site 698972006577 Q-loop/lid; other site 698972006578 ABC transporter signature motif; other site 698972006579 Walker B; other site 698972006580 D-loop; other site 698972006581 H-loop/switch region; other site 698972006582 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698972006583 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698972006584 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698972006585 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698972006586 Histidine kinase; Region: HisKA_3; pfam07730 698972006587 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698972006588 ATP binding site [chemical binding]; other site 698972006589 G-X-G motif; other site 698972006590 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698972006591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698972006592 active site 698972006593 phosphorylation site [posttranslational modification] 698972006594 intermolecular recognition site; other site 698972006595 dimerization interface [polypeptide binding]; other site 698972006596 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698972006597 DNA binding residues [nucleotide binding] 698972006598 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 698972006599 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698972006600 Predicted membrane protein [Function unknown]; Region: COG1511 698972006601 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698972006602 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698972006603 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698972006604 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698972006605 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698972006606 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698972006607 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 698972006608 NAD(P) binding site [chemical binding]; other site 698972006609 catalytic residues [active] 698972006610 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698972006611 active site 698972006612 phosphorylation site [posttranslational modification] 698972006613 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 698972006614 active site 698972006615 P-loop; other site 698972006616 phosphorylation site [posttranslational modification] 698972006617 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 698972006618 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 698972006619 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 698972006620 DAK2 domain; Region: Dak2; cl03685 698972006621 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 698972006622 active site 698972006623 active pocket/dimerization site; other site 698972006624 phosphorylation site [posttranslational modification] 698972006625 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698972006626 dimerization domain swap beta strand [polypeptide binding]; other site 698972006627 regulatory protein interface [polypeptide binding]; other site 698972006628 active site 698972006629 regulatory phosphorylation site [posttranslational modification]; other site 698972006630 AAA domain; Region: AAA_21; pfam13304 698972006631 AAA domain; Region: AAA_21; pfam13304 698972006632 Putative esterase; Region: Esterase; pfam00756 698972006633 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 698972006634 active site 698972006635 Cobalt transport protein; Region: CbiQ; cl00463 698972006636 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972006637 ABC transporter signature motif; other site 698972006638 Walker B; other site 698972006639 D-loop; other site 698972006640 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698972006641 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698972006642 Walker A/P-loop; other site 698972006643 ATP binding site [chemical binding]; other site 698972006644 Q-loop/lid; other site 698972006645 ABC transporter signature motif; other site 698972006646 Walker B; other site 698972006647 D-loop; other site 698972006648 H-loop/switch region; other site 698972006649 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 698972006650 active site 698972006651 catalytic residues [active] 698972006652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 698972006653 hypothetical protein; Provisional; Region: PRK13663 698972006654 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698972006655 putative active site [active] 698972006656 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698972006657 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 698972006658 SdpI/YhfL protein family; Region: SdpI; pfam13630 698972006659 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698972006660 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698972006661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698972006662 catalytic residue [active] 698972006663 anthranilate synthase component I; Provisional; Region: PRK13564 698972006664 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 698972006665 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698972006666 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698972006667 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698972006668 glutamine binding [chemical binding]; other site 698972006669 catalytic triad [active] 698972006670 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 698972006671 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698972006672 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698972006673 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 698972006674 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698972006675 active site 698972006676 ribulose/triose binding site [chemical binding]; other site 698972006677 phosphate binding site [ion binding]; other site 698972006678 substrate (anthranilate) binding pocket [chemical binding]; other site 698972006679 product (indole) binding pocket [chemical binding]; other site 698972006680 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 698972006681 active site 698972006682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 698972006683 pantoate--beta-alanine ligase; Region: panC; TIGR00018 698972006684 Pantoate-beta-alanine ligase; Region: PanC; cd00560 698972006685 active site 698972006686 ATP-binding site [chemical binding]; other site 698972006687 pantoate-binding site; other site 698972006688 HXXH motif; other site 698972006689 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 698972006690 oligomerization interface [polypeptide binding]; other site 698972006691 active site 698972006692 metal binding site [ion binding]; metal-binding site 698972006693 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698972006694 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698972006695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698972006696 catalytic residue [active] 698972006697 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 698972006698 substrate binding site [chemical binding]; other site 698972006699 active site 698972006700 catalytic residues [active] 698972006701 heterodimer interface [polypeptide binding]; other site 698972006702 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698972006703 iron-sulfur cluster [ion binding]; other site 698972006704 [2Fe-2S] cluster binding site [ion binding]; other site 698972006705 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 698972006706 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698972006707 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 698972006708 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 698972006709 hypothetical protein; Validated; Region: PRK00228 698972006710 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 698972006711 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 698972006712 active site 698972006713 NTP binding site [chemical binding]; other site 698972006714 metal binding triad [ion binding]; metal-binding site 698972006715 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 698972006716 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698972006717 Zn2+ binding site [ion binding]; other site 698972006718 Mg2+ binding site [ion binding]; other site 698972006719 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 698972006720 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698972006721 active site 698972006722 Ap6A binding site [chemical binding]; other site 698972006723 nudix motif; other site 698972006724 metal binding site [ion binding]; metal-binding site 698972006725 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 698972006726 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 698972006727 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 698972006728 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698972006729 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698972006730 DNA binding residues [nucleotide binding] 698972006731 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 698972006732 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698972006733 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698972006734 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698972006735 catalytic residues [active] 698972006736 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698972006737 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698972006738 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 698972006739 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 698972006740 active site 698972006741 metal binding site [ion binding]; metal-binding site 698972006742 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 698972006743 ParB-like nuclease domain; Region: ParBc; pfam02195 698972006744 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698972006745 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698972006746 P-loop; other site 698972006747 Magnesium ion binding site [ion binding]; other site 698972006748 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698972006749 Magnesium ion binding site [ion binding]; other site 698972006750 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 698972006751 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 698972006752 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 698972006753 ribonuclease P; Reviewed; Region: rnpA; PRK03459 698972006754 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399