-- dump date 20140619_051152 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type NP_938410.1 38232643 2650569 19..1677 1 NC_002935.2 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosome replication initiator DnaA 1677 dnaA 2650569 dnaA Corynebacterium diphtheriae NCTC 13129 chromosome replication initiator DnaA NP_938410.1 19 D 257309 CDS NP_938411.2 161598680 2649984 2316..3503 1 NC_002935.2 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 3503 dnaN 2649984 dnaN Corynebacterium diphtheriae NCTC 13129 DNA polymerase III subunit beta NP_938411.2 2316 D 257309 CDS NP_938412.1 38232645 2650258 3542..4735 1 NC_002935.2 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 4735 recF 2650258 recF Corynebacterium diphtheriae NCTC 13129 recombination protein F NP_938412.1 3542 D 257309 CDS NP_938413.1 38232646 2650606 4725..5276 1 NC_002935.2 Similar to Mycobacterium paratuberculosis hypothetical 17.5 kDa protein TR:Q9L7L4 (EMBL:AF222789) (166 aa) fasta scores: E(): 5.6e-18, 45.45% id in 143 aa; hypothetical protein 5276 2650606 DIP0004 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938413.1 4725 D 257309 CDS NP_938414.1 38232647 2650607 5379..7436 1 NC_002935.2 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 7436 gyrB 2650607 gyrB Corynebacterium diphtheriae NCTC 13129 DNA gyrase subunit B NP_938414.1 5379 D 257309 CDS NP_938415.1 38232648 2648824 complement(7503..7940) 1 NC_002935.2 Doubtful CDS. No significant database matches; hypothetical protein 7940 2648824 DIP0006 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938415.1 7503 R 257309 CDS NP_938416.1 38232649 2648825 complement(8201..8473) 1 NC_002935.2 Doubtful CDS. No significant database matches; hypothetical protein 8473 2648825 DIP0007 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938416.1 8201 R 257309 CDS NP_938417.1 38232650 2648826 complement(8478..8681) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 7.1 kDa protein SC10A5.13 TR:O54104 (EMBL:AL021529) (64 aa) fasta scores: E(): 0.18, 52.5% id in 40 aa; hypothetical protein 8681 2648826 DIP0008 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938417.1 8478 R 257309 CDS NP_938418.1 38232651 2648827 8792..11362 1 NC_002935.2 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 11362 gyrA 2648827 gyrA Corynebacterium diphtheriae NCTC 13129 DNA gyrase subunit A NP_938418.1 8792 D 257309 CDS NP_938419.1 38232652 2650417 11362..11706 1 NC_002935.2 Similar in its C-terminal region to Mycobacterium leprae hypothetical 32.2 kDa protein MLB1770.07 or ML0007 TR:O32870 (EMBL:Z70722) (303 aa) fasta scores: E(): 9.9e-08, 36.28% id in 113 aa; hypothetical protein 11706 2650417 DIP0010 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938419.1 11362 D 257309 CDS NP_938420.1 38232653 2650420 complement(12176..12904) 1 NC_002935.2 Similar to Escherichia coli glc operon transcriptional activator GlcC or B2980 SW:GLCC_ECOLI (P52072) (254 aa) fasta scores: E(): 1.2e-05, 23.5% id in 234 aa; regulatory protein 12904 2650420 DIP0011 Corynebacterium diphtheriae NCTC 13129 regulatory protein NP_938420.1 12176 R 257309 CDS NP_938421.1 38232654 2648748 complement(12992..14662) 1 NC_002935.2 Similar to Escherichia coli L-lactate permease LldP or LctP or B3603 SW:LLDP_ECOLI (P33231) (551 aa) fasta scores: E(): 2.4e-68, 40.1% id in 561 aa; L-lactate permease 14662 lldP 2648748 lldP Corynebacterium diphtheriae NCTC 13129 L-lactate permease NP_938421.1 12992 R 257309 CDS NP_938422.1 38232655 2648555 15159..15632 1 NC_002935.2 hypothetical protein 15632 2648555 DIP0013 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938422.1 15159 D 257309 CDS NP_938423.1 38232656 2648556 15721..17364 1 NC_002935.2 Low similarity to Staphylococcus aureus subsp aureus N315 SA0639 protein TR:Q99VT7 (EMBL:AP003131) (543 aa) fasta scores: E(): 3e-23, 25.56% id in 485 aa; hypothetical protein 17364 2648556 DIP0014 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938423.1 15721 D 257309 CDS NP_938424.1 38232657 2649060 17354..19000 1 NC_002935.2 Similar to Escherichia coli, and Escherichia coli O157:H7 probable transport ATP-binding protein MsbA or B0914 or Z1260 or ECS0997 SWALL:MSBA_ECOLI (SWALL:P27299) (582 aa) fasta scores: E(): 7e-30, 26.73% id in 561 aa, and to Pasteurella multocida hypothetical protein PM1473 TR:Q9CKX8 (EMBL:AE006183) (552 aa) fasta scores: E(): 6.1e-33, 27.97% id in 554 aa; transport system, ATP-binding protein 19000 2649060 DIP0015 Corynebacterium diphtheriae NCTC 13129 transport system, ATP-binding protein NP_938424.1 17354 D 257309 CDS NP_938425.1 38232658 2650598 <19447..19767 1 NC_002935.2 No database matches. Possible membrane protein; hypothetical protein 19767 2650598 DIP0016 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938425.1 <19447 D 257309 CDS NP_938426.1 38232659 2650599 19865..20029 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 20029 2650599 DIP0017 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938426.1 19865 D 257309 CDS NP_938427.1 38232660 2650601 20524..20721 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 20721 2650601 DIP0018 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938427.1 20524 D 257309 CDS NP_938428.1 38232661 2650602 complement(20713..20958) 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 20958 2650602 DIP0019 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938428.1 20713 R 257309 CDS NP_938429.1 38232662 2650603 complement(20955..21185) 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 21185 2650603 DIP0020 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938429.1 20955 R 257309 CDS NP_938430.1 38232663 2650604 21381..22379 1 NC_002935.2 Similar to Streptomyces coelicolor probable solute-binding lipoprotein SC8F11.05 TR:Q9KZH3 (EMBL:AL353864) (340 aa) fasta scores: E(): 2.8e-63, 54.98% id in 331 aa; solute-binding lipoprotein 22379 2650604 DIP0021 Corynebacterium diphtheriae NCTC 13129 solute-binding lipoprotein NP_938430.1 21381 D 257309 CDS NP_938431.1 38232664 2650605 22376..23407 1 NC_002935.2 Similar to Streptomyces coelicolor probable ABC transport protein, membrane component SC8F11.06 TR:Q9KZH2 (EMBL:AL353864) (359 aa) fasta scores: E(): 1.1e-72, 57.66% id in 326 aa; ABC transporter 23407 2650605 DIP0022 Corynebacterium diphtheriae NCTC 13129 ABC transporter NP_938431.1 22376 D 257309 CDS NP_938432.1 38232665 2648749 23408..24169 1 NC_002935.2 Similar to Streptomyces coelicolor probable ABC transport protein, ATP-binding component SC8F11.07 TR:Q9KZH1 (EMBL:AL353864) (330 aa) fasta scores: E(): 2.8e-51, 62.15% id in 251 aa; ABC transporter ATP-binding protein 24169 2648749 DIP0023 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_938432.1 23408 D 257309 CDS NP_938433.1 38232666 2648750 complement(24217..24825) 1 NC_002935.2 Possible membrane protein. No database matches; hypothetical protein 24825 2648750 DIP0024 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938433.1 24217 R 257309 CDS NP_938434.1 38232667 2648751 24888..25430 1 NC_002935.2 Similar to Mycobacterium tuberculosis probable peptidyl-prolyl cis-trans isomerase A PpiA or Rv0009 or MT0011 or MTCY10H4.08 SW:PPIA_MYCTU (P71578) (182 aa) fasta scores: E(): 4.7e-52, 78.36% id in 171 aa; peptidyl-prolyl cis-trans isomerase A 25430 ppiA 2648751 ppiA Corynebacterium diphtheriae NCTC 13129 peptidyl-prolyl cis-trans isomerase A NP_938434.1 24888 D 257309 CDS NP_938435.1 38232668 2650199 complement(25519..>25752) 1 NC_002935.2 Similar to Streptococcus mutans transposase (fragment) TR:Q9ZHF4 (EMBL:AF065413) (75 aa) fasta scores: E(): 3.5e-11, 47.22% id in 72 aa; transposase (partial) >25752 2650199 DIP0026 Corynebacterium diphtheriae NCTC 13129 transposase (partial) NP_938435.1 25519 R 257309 CDS NP_938436.1 38232669 2650611 25877..26494 1 NC_002935.2 Similar to Mycobacterium tuberculosis transmembrane protein Rv0110 or MTV031.04 TR:O53632 (EMBL:AL021926) (249 aa) fasta scores: E(): 1.4e-13, 34.19% id in 193 aa; hypothetical protein 26494 2650611 DIP0027 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938436.1 25877 D 257309 CDS NP_938437.1 38232670 2650612 complement(26672..27025) 1 NC_002935.2 hypothetical protein 27025 2650612 DIP0028 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938437.1 26672 R 257309 CDS NP_938438.1 38232671 2650613 27567..29366 1 NC_002935.2 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 29366 thiC 2650613 thiC Corynebacterium diphtheriae NCTC 13129 thiamine biosynthesis protein ThiC NP_938438.1 27567 D 257309 CDS NP_938439.1 38232672 2650614 29350..30018 1 NC_002935.2 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 30018 thiE 2650614 thiE Corynebacterium diphtheriae NCTC 13129 thiamine-phosphate pyrophosphorylase NP_938439.1 29350 D 257309 CDS NP_938440.1 38232673 2650615 30015..31103 1 NC_002935.2 Similar to Rhizobium etli thiamine biosynthesis oxidoreductase ThiO SW:THIO_RHIET (O34292) (327 aa) fasta scores: E(): 5.4e-09, 31.67% id in 341 aa; thiamine biosynthesis oxidoreductase 31103 thiO 2650615 thiO Corynebacterium diphtheriae NCTC 13129 thiamine biosynthesis oxidoreductase NP_938440.1 30015 D 257309 CDS NP_938441.1 38232674 2650184 31087..31287 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 6.6 kDa protein SC6E10.02 TR:Q9S2N5 (EMBL:AL109661) (66 aa) fasta scores: E(): 1.1e-06, 36.36% id in 66 aa; hypothetical protein 31287 2650184 DIP0032 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938441.1 31087 D 257309 CDS NP_938442.1 38232675 2650185 31289..32074 1 NC_002935.2 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 32074 thiG 2650185 thiG Corynebacterium diphtheriae NCTC 13129 thiazole synthase NP_938442.1 31289 D 257309 CDS NP_938443.1 38232676 2650186 32071..33084 1 NC_002935.2 catalyzes the adenylation of ThiS which is involved in the formation of 5-methyl-4-(beta-hydroxyethyl)thiazole phosphate; thiamine biosynthesis protein ThiF 33084 2650186 DIP0034 Corynebacterium diphtheriae NCTC 13129 thiamine biosynthesis protein ThiF NP_938443.1 32071 D 257309 CDS NP_938444.1 38232677 2650187 33081..33899 1 NC_002935.2 Similar to Escherichia coli phosphomethylpyrimidine kinase ThiD or B2103 SW:THID_ECOLI (P76422) (266 aa) fasta scores: E(): 5.5e-30, 44.9% id in 265 aa; phosphomethylpyrimidine kinase 33899 thiD 2650187 thiD Corynebacterium diphtheriae NCTC 13129 phosphomethylpyrimidine kinase NP_938444.1 33081 D 257309 CDS NP_938445.1 38232678 2650188 34478..37732 1 NC_002935.2 Similar in its N-terminal region to Pasteurella multocida hypothetical protein PM1127 TR:Q9CLT2 (EMBL:AE006153) (1056 aa) fasta scores: E(): 1.4e-15, 21.94% id in 802 aa; hypothetical protein 37732 2650188 DIP0036 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938445.1 34478 D 257309 CDS NP_938446.1 38232679 2650439 37736..38650 1 NC_002935.2 Similar to Neisseria meningitidis hypothetical protein NMA0630 TR:Q9JVY0 (EMBL:AL162753) (304 aa) fasta scores: E(): 2.7e-22, 37.5% id in 256 aa, and to Pasteurella multocida hypothetical protein PM1126 TR:Q9CLT3 (EMBL:AE006153) (343 aa) fasta scores: E(): 3.5e-22, 32.04% id in 284 aa; hypothetical protein 38650 2650439 DIP0037 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938446.1 37736 D 257309 CDS NP_938447.1 38232680 2650440 38634..38963 1 NC_002935.2 Similar to Pasteurella multocida hypothetical protein PM1125 TR:Q9CLT4 (EMBL:AE006153) (108 aa) fasta scores: E(): 9.3e-07, 42.85% id in 77 aa; hypothetical protein 38963 2650440 DIP0038 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938447.1 38634 D 257309 CDS NP_938448.1 38232681 2650441 complement(38967..39077) 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 39077 2650441 DIP0039 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938448.1 38967 R 257309 CDS NP_938449.1 38232682 2650442 complement(39311..39592) 1 NC_002935.2 Similar to the C-terminal region of Rickettsia prowazekii hypothetical protein RP756 SW:Y756_RICPR (Q9ZCI4) (105 aa) fasta scores: E(): 3.4, 33.33% id in 51 aa; hypothetical protein 39592 2650442 DIP0040 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938449.1 39311 R 257309 CDS NP_938450.1 38232683 2648893 complement(40822..40923) 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 40923 2648893 DIP0046 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938450.1 40822 R 257309 CDS NP_938451.1 38232684 2648894 complement(join(41066..42397,42420..42614)) 1 NC_002935.2 Similar to Mycobacterium smegmatis transposase TR:O70063 (EMBL:AF036759) (503 aa) fasta scores: E(): 4.7e-88, 50% id in 498 aa. Presents a frameshift at residue 65; transposase 42614 2648894 DIP0047 Corynebacterium diphtheriae NCTC 13129 transposase NP_938451.1 41066 R 257309 CDS NP_938452.1 38232685 2648895 <42736..42969 1 NC_002935.2 Similar to Corynebacterium jeikeium transposase B TnpB TR:AAK67710 (EMBL:AY036070) (302 aa) fasta scores: E(): 1.2e-06, 45.45% id in 55 aa, and to Escherichia coli O157:H7 EDL933 partial transposase Z1207 TR:AAG55352 (EMBL:AE005276) (82 aa) fasta scores: E(): 5.2e-05, 38% id in 50 aa; transposase (partial) 42969 2648895 DIP0049 Corynebacterium diphtheriae NCTC 13129 transposase (partial) NP_938452.1 <42736 D 257309 CDS NP_938453.1 38232686 2648896 43101..43196 1 NC_002935.2 Doubtful CDS. No significant database matches; hypothetical protein 43196 2648896 DIP0050 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938453.1 43101 D 257309 CDS NP_938454.1 38232687 2648897 43189..43284 1 NC_002935.2 Doubtful CDS. No significant database matches; hypothetical protein 43284 2648897 DIP0051 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938454.1 43189 D 257309 CDS NP_938455.1 38232688 2648898 complement(43308..43577) 1 NC_002935.2 integral membrane protein involved in inhibition of the Z-ring formation; septation inhibitor protein 43577 2648898 DIP0052 Corynebacterium diphtheriae NCTC 13129 septation inhibitor protein NP_938455.1 43308 R 257309 CDS NP_938456.1 38232689 2648899 complement(43694..45715) 1 NC_002935.2 Similar to Mycobacterium leprae probable serine/threonine-protein kinase PknB or ML0016 SW:PKNB_MYCLE (P54744) (622 aa) fasta scores: E(): 5.7e-58, 43.26% id in 661 aa; serine/threonine-protein kinase 45715 pknB 2648899 pknB Corynebacterium diphtheriae NCTC 13129 serine/threonine-protein kinase NP_938456.1 43694 R 257309 CDS NP_938457.1 38232690 2649543 complement(45712..47217) 1 NC_002935.2 Similar to Mycobacterium leprae probable serine/threonine-protein kinase PnkA or ML0017 SW:PKNA_MYCLE (P54743) (437 aa) fasta scores: E(): 4e-37, 41.99% id in 431 aa; serine/threonine-protein kinase 47217 pknA 2649543 pknA Corynebacterium diphtheriae NCTC 13129 serine/threonine-protein kinase NP_938457.1 45712 R 257309 CDS NP_938458.1 38232691 2650426 complement(47230..48690) 1 NC_002935.2 Similar to Mycobacterium leprae penicillin-binding protein PbpA or ML0018 TR:Q9CDE6 (EMBL:AL583917) (492 aa) fasta scores: E(): 1.3e-72, 45.9% id in 488 aa; secreted penicillin-binding protein 48690 pbpA 2650426 pbpA Corynebacterium diphtheriae NCTC 13129 secreted penicillin-binding protein NP_938458.1 47230 R 257309 CDS NP_938459.1 38232692 2650427 complement(48687..50036) 1 NC_002935.2 Similar to Mycobacterium tuberculosis probable cell division protein FtsW or Rv0017c or MT0020 or MTCY10H4.17c SW:FTSW_MYCTU (P71587) (469 aa) fasta scores: E(): 8.7e-72, 48.61% id in 434 aa, and to Escherichia coli rod shape-determining protein MrdB or RodA or B0634 or Z0780 or ECS0672 SW:RODA_ECOLI (P15035) (370 aa) fasta scores: E(): 8.5e-19, 26.57% id in 365 aa; cell division protein 50036 ftsW 2650427 ftsW Corynebacterium diphtheriae NCTC 13129 cell division protein NP_938459.1 48687 R 257309 CDS NP_938460.1 38232693 2650428 complement(50037..51494) 1 NC_002935.2 Similar to Mycobacterium leprae probable phosphoprotein phosphatase Ppp TR:Q50188 (EMBL:Z70722) (509 aa) fasta scores: E(): 5.8e-46, 43.64% id in 488 aa; phosphoprotein phosphatase 51494 2650428 DIP0057 Corynebacterium diphtheriae NCTC 13129 phosphoprotein phosphatase NP_938460.1 50037 R 257309 CDS NP_938461.1 38232694 2650564 complement(51491..51979) 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical 17.2 kDa protein MLB1770.14c or ML0021 TR:Q50189 (EMBL:Z70722) (155 aa) fasta scores: E(): 2.3e-13, 35% id in 160 aa; hypothetical protein 51979 2650564 DIP0058 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938461.1 51491 R 257309 CDS NP_938462.1 38232695 2650565 complement(51993..52859) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 30.8 kDa protein SCH69.13 TR:Q9XA21 (EMBL:AL079308) (290 aa) fasta scores: E(): 3.1e-11, 27.6% id in 297 aa; hypothetical protein 52859 2650565 DIP0059 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938462.1 51993 R 257309 CDS NP_938463.1 38232696 2650568 complement(53813..56047) 1 NC_002935.2 Similar to Enterococcus hirae probable copper exporting ATPase B CopB SW:COPB_ENTHR (P05425) (745 aa) fasta scores: E(): 2.2e-94, 43.228% id in 731 aa, and to Mycobacterium tuberculosis probable cation-transporting ATPase V CtpV or Rv0969 or MT0997 or MTCY10D7.05c SW:CTPV_MYCTU (P77894) (770 aa) fasta scores: E(): 2e-69, 40.092% id in 651 aa; cation-transporting ATPase 56047 2650568 DIP0061 Corynebacterium diphtheriae NCTC 13129 cation-transporting ATPase NP_938463.1 53813 R 257309 CDS NP_938464.1 38232697 2649058 complement(56099..56425) 1 NC_002935.2 Similar to Deinococcus radiodurans conserved hypothetical protein DR2452 TR:Q9RRN6 (EMBL:AE002074) (68 aa) fasta scores: E(): 0.0038, 43.103% id in 58 aa, and to Streptococcus pyogenes copper chaperone-copper transport operon CopZ or SPY1714 TR:Q99YG6 (EMBL:AE006600) (67 aa) fasta scores: E(): 0.0065, 40.000% id in 60 aa, and to Pseudomonas syringae Plasmid pPaCu1 copper resistance operon ORFH protein TR:Q9KWM7 (EMBL:AB033420) (65 aa) fasta scores: E(): 0.025, 40.000% id in 60 aa, and to Candida albicans copper-transporting p-type ATPase Ccc2 TR:AAK52331 (EMBL:AY033084) (1204 aa) fasta scores: E(): 0.03, 28.571% id in 84 aa; heavy metal-associated transport protein 56425 2649058 DIP0062 Corynebacterium diphtheriae NCTC 13129 heavy metal-associated transport protein NP_938464.1 56099 R 257309 CDS NP_938465.1 38232698 2649059 complement(56540..57667) 1 NC_002935.2 Similar to Escherichia coli sensor protein BaeS or B2078 SW:BAES_ECOLI (P30847) (467 aa) fasta scores: E(): 1.8e-28, 33.333% id in 372 aa; two-component system sensor protein 57667 2649059 DIP0063 Corynebacterium diphtheriae NCTC 13129 two-component system sensor protein NP_938465.1 56540 R 257309 CDS NP_938466.1 38232699 2650608 complement(57664..58386) 1 NC_002935.2 Similar to Enterococcus faecalis VicR protein TR:Q9REA7 (EMBL:AJ012050) (283 aa) fasta scores: E(): 5.5e-35, 44.978% id in 229 aa, to Bacillus subtilis alkaline phosphatase synthesis transcriptional regulatory protein PhoP SW:PHOP_BACSU (P13792) (240 aa) fasta scores: E(): 3e-34, 42.918% id in 233 aa, and to Bacillus subtilis hypothetical sensory transduction protein YycF SW:YYCF_BACSU (P37478) (235 aa) fasta scores: E(): 1.8e-33, 43.478% id in 230 aa; two-component system response regulator 58386 2650608 DIP0064 Corynebacterium diphtheriae NCTC 13129 two-component system response regulator NP_938466.1 57664 R 257309 CDS NP_938467.1 38232700 2650609 58730..59365 1 NC_002935.2 No database matches; hypothetical protein 59365 2650609 DIP0066 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938467.1 58730 D 257309 CDS NP_938468.1 38232701 2650610 59436..60917 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 copper-binding protein, MT0869 TR:AAK45112 (EMBL:AE006975) (504 aa) fasta scores: E(): 9e-68, 43.028% id in 502 aa, and to Nicotiana tabacum L-ascorbate oxidase precursor Aao SW:ASO_TOBAC (Q40588) (578 aa) fasta scores: E(): 2.5e-14, 25.344% id in 509 aa. Note: Contains a twin-arginine translocation (TAT) system recognition motif (RRQFLL) at the N-terminal region; exported multicopper oxidase 60917 2650610 DIP0067 Corynebacterium diphtheriae NCTC 13129 exported multicopper oxidase NP_938468.1 59436 D 257309 CDS NP_938469.1 38232702 2649666 complement(60895..61203) 1 NC_002935.2 Weak similarities to Streptomyces coelicolor DNA polymerase III, epsilon chain SCI8.12 TR:Q9RJ41 (EMBL:AL132644) (328 aa) fasta scores: E(): 2.7, 42.22% id in 45 aa, and to Thermotoga maritima DNA polymerase III PolC-type PolC or TM0576 SW:DPO3_THEMA (Q9ZHF6) (1367 aa) fasta scores: E(): 9.3, 39.58% id in 48 aa; hypothetical protein 61203 2649666 DIP0068 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938469.1 60895 R 257309 CDS NP_938470.1 38232703 2649668 complement(62898..63353) 1 NC_002935.2 hypothetical protein 63353 2649668 DIP0071 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938470.1 62898 R 257309 CDS NP_938471.1 38232704 2649669 complement(63350..63850) 1 NC_002935.2 hypothetical protein 63850 2649669 DIP0072 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938471.1 63350 R 257309 CDS NP_938472.1 38232705 2649670 complement(63823..64218) 1 NC_002935.2 Weakly similar to Rhizobium loti MLR2640 protein TR:Q98HZ4 (EMBL:AP003000) (140 aa) fasta scores: E(): 4.2, 27.1% id in 107 aa; Conserved hypothetical protein; hypothetical protein 64218 2649670 DIP0073 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938472.1 63823 R 257309 CDS NP_938473.1 38232706 2649671 complement(64253..64393) 1 NC_002935.2 Doubtful CDS. No significant database matches; hypothetical protein 64393 2649671 DIP0074 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938473.1 64253 R 257309 CDS NP_938474.1 38232707 2649672 64602..66083 1 NC_002935.2 hypothetical protein 66083 2649672 DIP0075 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938474.1 64602 D 257309 CDS NP_938475.1 38232708 2649673 66426..66797 1 NC_002935.2 hypothetical protein 66797 2649673 DIP0076 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938475.1 66426 D 257309 CDS NP_938476.1 38232709 2650189 66921..67721 1 NC_002935.2 hypothetical protein 67721 2650189 DIP0077 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938476.1 66921 D 257309 CDS NP_938477.1 38232710 2650190 67740..68582 1 NC_002935.2 hypothetical protein 68582 2650190 DIP0078 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938477.1 67740 D 257309 CDS NP_938478.1 38232711 2650191 68563..69828 1 NC_002935.2 hypothetical protein 69828 2650191 DIP0079 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938478.1 68563 D 257309 CDS NP_938479.1 38232712 2650192 69994..70125 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 70125 2650192 DIP0080 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938479.1 69994 D 257309 CDS NP_938480.1 38232713 2650193 70294..70473 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 70473 2650193 DIP0081 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938480.1 70294 D 257309 CDS NP_938481.1 38232714 2650194 70504..70929 1 NC_002935.2 Possible secreted protein. No database matches; hypothetical protein 70929 2650194 DIP0082 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938481.1 70504 D 257309 CDS NP_938482.1 38232715 2650195 70997..71137 1 NC_002935.2 Doubtful CDS. No significant database matches; hypothetical protein 71137 2650195 DIP0083 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938482.1 70997 D 257309 CDS NP_938483.1 38232716 2650196 71572..71700 1 NC_002935.2 Doubtful CDS. Possible membrane protein. No database matches; hypothetical protein 71700 2650196 DIP0084 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938483.1 71572 D 257309 CDS NP_938484.1 38232717 2650197 complement(71845..72360) 1 NC_002935.2 Weakly similar to Euhadra herklotsi NADH dehydrogenase subunit 1 TR:O21342 (EMBL:Z71695) (296 aa) fasta scores: E(): 0.57, 24.16% id in 120 aa; hypothetical protein 72360 2650197 DIP0085 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938484.1 71845 R 257309 CDS NP_938485.1 38232718 2650198 complement(72365..72664) 1 NC_002935.2 Similar to Deinococcus radiodurans transcriptional regulator, HTH_3 family DR2259 TR:Q9RS68 (EMBL:AE002058) (82 aa) fasta scores: E(): 1.3e-10, 47.67% id in 86 aa; regulatory protein 72664 2650198 DIP0086 Corynebacterium diphtheriae NCTC 13129 regulatory protein NP_938485.1 72365 R 257309 CDS NP_938486.1 38232719 2649540 complement(73648..74943) 1 NC_002935.2 Weakly similar in its N-terminal region to Bacillus subtilis SpaE TR:O52853 (EMBL:U09819) (251 aa) fasta scores: E(): 0.0095, 21% id in 200 aa; hypothetical protein 74943 2649540 DIP0089 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938486.1 73648 R 257309 CDS NP_938487.1 38232720 2649541 complement(75080..75781) 1 NC_002935.2 Similar to Lactococcus lactis NisF TR:Q48597 (EMBL:U17255) (225 aa) fasta scores: E(): 1.3e-25, 43.8% id in 226 aa, and to Staphylococcus epidermidis ABC transporter subunit EpiF TR:Q54002 (EMBL:U77778) (231 aa) fasta scores: E(): 7.1e-21, 38.15% id in 228 aa; ABC transporter ATP-binding protein 75781 2649541 DIP0090 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_938487.1 75080 R 257309 CDS NP_938488.1 38232721 2649542 complement(75820..76479) 1 NC_002935.2 Similar to Streptomyces lividans response regulator homolog TR:P72471 (EMBL:U63847) (225 aa) fasta scores: E(): 2.7e-29, 42.98% id in 221 aa, and to Streptomyces coelicolor two-component system regulator SCH10.18c TR:Q9X8Q7 (EMBL:AL049754) (228 aa) fasta scores: E(): 3e-26, 38.53% id in 218 aa; two-component system response regulator 76479 2649542 DIP0091 Corynebacterium diphtheriae NCTC 13129 two-component system response regulator NP_938488.1 75820 R 257309 CDS NP_938489.1 38232722 2648506 complement(76479..77708) 1 NC_002935.2 Similar to Streptomyces coelicolor two component sensor kinase SC5F7.35c TR:Q9S2S0 (EMBL:AL096872) (416 aa) fasta scores: E(): 2.9e-17, 32.79% id in 308 aa, and to Streptomyces coelicolor two-component system sensor kinase SCH10.17c TR:Q9X8Q6 (EMBL:AL049754) (472 aa) fasta scores: E(): 1.1e-11, 33.61% id in 241 aa; two component system sensor kinase 77708 2648506 DIP0092 Corynebacterium diphtheriae NCTC 13129 two component system sensor kinase NP_938489.1 76479 R 257309 CDS NP_938490.1 38232723 2650560 complement(77804..78145) 1 NC_002935.2 Probable membrane protein. No database matches; hypothetical protein 78145 2650560 DIP0093 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938490.1 77804 R 257309 CDS NP_938491.1 38232724 2650561 complement(78214..78330) 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 78330 2650561 DIP0094 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938491.1 78214 R 257309 CDS NP_938492.1 38232725 2650562 complement(78414..79088) 1 NC_002935.2 Similar to Bacillus subtilis choline transport system permease OpuBB or ProW SW:OPBB_BACSU (Q45461) (217 aa) fasta scores: E(): 3e-14, 30.72% id in 192 aa, and to Mycobacterium tuberculosis transport system permease Rv3756c or MTV025.104c TR:O69722 (EMBL:AL022121) (239 aa) fasta scores: E(): 1.9e-28, 48.32% id in 209 aa; choline transport system permease 79088 opuBB 2650562 opuBB Corynebacterium diphtheriae NCTC 13129 choline transport system permease NP_938492.1 78414 R 257309 CDS NP_938493.1 38232726 2650563 complement(79095..79736) 1 NC_002935.2 Similar to Bacillus subtilis choline transport system permease OpuBD or ProZ SW:OPBD_BACSU (P39775) (226 aa) fasta scores: E(): 8.5e-13, 29.44% id in 197 aa, and to Mycobacterium tuberculosis transport system permease Rv3757c or MTV025.105c TR:O69723 (EMBL:AL022121) (229 aa) fasta scores: E(): 4.7e-25, 39.71% id in 209 aa; choline transport system permease 79736 opuBD 2650563 opuBD Corynebacterium diphtheriae NCTC 13129 choline transport system permease NP_938493.1 79095 R 257309 CDS NP_938494.1 38232727 2648515 complement(79727..80557) 1 NC_002935.2 Similar to Bacillus subtilis choline transport ATP-binding protein OpuBA or ProV SW:OPBA_BACSU (Q45460) (381 aa) fasta scores: E(): 2.5e-42, 50.58% id in 255 aa, and to Mycobacterium tuberculosis ABC transporter ATP-binding protein Rv3758c or MTV025.106c TR:O69724 (EMBL:AL022121) (376 aa) fasta scores: E(): 1.3e-42, 53.62% id in 248 aa; choline transport system ATP-binding protein 80557 opuBA 2648515 opuBA Corynebacterium diphtheriae NCTC 13129 choline transport system ATP-binding protein NP_938494.1 79727 R 257309 CDS NP_938495.1 38232728 2648516 complement(80567..81175) 1 NC_002935.2 Weakly similar to Mycobacterium tuberculosis hypothetical 23.9 kDa protein Rv0444c or MTV037.08C TR:O53729 (EMBL:AL021932) (232 aa) fasta scores: E(): 0.004, 25.94% id in 212 aa; hypothetical protein 81175 2648516 DIP0098 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938495.1 80567 R 257309 CDS NP_938496.1 38232729 2648517 complement(81172..81756) 1 NC_002935.2 Similar to Streptomyces coelicolor RNA polymerase sigma factor SCI11.12c TR:Q9S2A7 (EMBL:AL096849) (185 aa) fasta scores: E(): 2.8e-25, 47.36% id in 171 aa, and to Bacillus subtilis RNA polymerase sigma factor SigW SW:SIGW_BACSU (Q45585) (187 aa) fasta scores: E(): 3.9e-10, 31.39% id in 172 aa; RNA polymerase sigma factor 81756 2648517 DIP0099 Corynebacterium diphtheriae NCTC 13129 RNA polymerase sigma factor NP_938496.1 81172 R 257309 CDS NP_938497.1 38232730 2650499 complement(81783..82181) 1 NC_002935.2 hypothetical protein 82181 2650499 DIP0100 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938497.1 81783 R 257309 CDS NP_938498.1 38232731 2650500 82259..83899 1 NC_002935.2 Similar to Mycobacterium tuberculosis DipZ protein Rv2874 or MT2942 or MTCY274.05 SW:DIPZ_MYCTU (Q10801) (695 aa) fasta scores: E(): 1.6e-43, 43.65% id in 591 aa; hypothetical protein 83899 2650500 DIP0101 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938498.1 82259 D 257309 CDS NP_938499.1 38232732 2650501 complement(83969..84745) 1 NC_002935.2 Similar to Streptomyces coelicolor transcriptional activator TipA or SCE9.20 SW:TIPA_STRCO (P32184) (253 aa) fasta scores: E(): 5.3e-24, 35.85% id in 251 aa; transcriptional activator 84745 tipA 2650501 tipA Corynebacterium diphtheriae NCTC 13129 transcriptional activator NP_938499.1 83969 R 257309 CDS NP_938500.1 38232733 2649070 complement(84797..84964) 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical protein ML2114 TR:Q9CBE3 (EMBL:AL583924) (56 aa) fasta scores: E(): 1.7e-05, 52.08% id in 48 aa; hypothetical protein 84964 2649070 DIP0103 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938500.1 84797 R 257309 CDS NP_938501.1 38232734 2649071 complement(84975..86321) 1 NC_002935.2 Similar to Streptomyces coelicolor peptidase SCI52.18c TR:Q9AD91 (EMBL:AL590507) (445 aa) fasta scores: E(): 1e-31, 32.04% id in 440 aa; peptidase 86321 2649071 DIP0104 Corynebacterium diphtheriae NCTC 13129 peptidase NP_938501.1 84975 R 257309 CDS NP_938502.1 38232735 2649072 86342..87394 1 NC_002935.2 catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine; biotin synthase 87394 bioB 2649072 bioB Corynebacterium diphtheriae NCTC 13129 biotin synthase NP_938502.1 86342 D 257309 CDS NP_938503.1 38232736 2649073 87394..87654 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 8.6 kDa protein Rv1590 or MT1625 or MTCY336.14c TR:O06600 (EMBL:Z95586) (79 aa) fasta scores: E(): 4.1e-11, 67.24% id in 58 aa; hypothetical protein 87654 2649073 DIP0106 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938503.1 87394 D 257309 CDS NP_938504.1 38232737 2649038 88041..89228 1 NC_002935.2 Almost identical to previously sequenced Corynebacterium diphtheriae ferrisiderophore receptor Irp6A SWALL:Q8VVA8 (EMBL:AY061890) (395 aa) fasta scores: E(): 8.7e-146, 97.46% id in 395 aa; ferrisiderophore receptor Irp6A 89228 irp6A 2649038 irp6A Corynebacterium diphtheriae NCTC 13129 ferrisiderophore receptor Irp6A NP_938504.1 88041 D 257309 CDS NP_938505.1 38232738 2649039 89229..90272 1 NC_002935.2 Almost identical to previously sequenced Corynebacterium diphtheriae membrane protein permease Irp6B SWALL:Q8VVA7 (EMBL:AY061890) (347 aa) fasta scores: E(): 1e-116, 98.27% id in 347 aa and similar to Rhizobium meliloti iron ABC transporter permease SMB21430 TR:CAC49658 (EMBL:AL603646) (356 aa) fasta scores: E(): 1.6e-55, 50.87% id in 342 aa and to Corynebacterium diphtheriae HmuU SWALL:Q9XD88 (EMBL:AF109162) (350 aa) fasta scores: E(): 2.1e-36, 40.66% id in 332 aa; membrane protein permease Irp6B 90272 irp6B 2649039 irp6B Corynebacterium diphtheriae NCTC 13129 membrane protein permease Irp6B NP_938505.1 89229 D 257309 CDS NP_938506.1 38232739 2649040 90274..91032 1 NC_002935.2 Almost identical to previously sequenced Corynebacterium diphtheriae ATP-binding protein Irp6C SWALL:Q8VVA6 (EMBL:AY061890) (252 aa) fasta scores: E(): 1.4e-79, 99.6% id in 252 aa and similar to Escherichia coli iron FecE or B4287 SWALL:FECE_ECOLI (SWALL:P15031) (255 aa) fasta scores: E(): 5.7e-19, 37.64% id in 263 aa; ATP-binding protein Irp6C 91032 irp6C 2649040 irp6C Corynebacterium diphtheriae NCTC 13129 ATP-binding protein Irp6C NP_938506.1 90274 D 257309 CDS NP_938507.1 38232740 2650429 91122..92600 1 NC_002935.2 Similar to Corynebacterium glutamicum ATCC 13032 hypothetical protein CGL1283 SWALL:BAB98676 (EMBL:AP005278) (581 aa) fasta scores: E(): 1.8e-63, 45.63% id in 504 aa; lipoprotein 92600 2650429 DIP0111 Corynebacterium diphtheriae NCTC 13129 lipoprotein NP_938507.1 91122 D 257309 CDS NP_938508.1 38232741 2650430 92618..93025 1 NC_002935.2 Similar to Bacillus subtilis YdhG protein TR:O05499 (EMBL:D88802) (135 aa) fasta scores: E(): 2.3e-20, 41.46% id in 123 aa; hypothetical protein 93025 2650430 DIP0112 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938508.1 92618 D 257309 CDS NP_938509.1 38232742 2650431 93040..94380 1 NC_002935.2 Similar to Streptomyces griseus deoxyribodipyrimidine photolyase Phr SW:PHR_STRGR (P12768) (455 aa) fasta scores: E(): 3.5e-36, 36.75% id in 468 aa, and to Escherichia coli deoxyribodipyrimidine photolyase PhrB or Phr or B0708 SW:PHR_ECOLI (P00914) (472 aa) fasta scores: E(): 9.9e-32, 34.01% id in 488 aa; riboflavin biosynthesis protein 94380 2650431 DIP0113 Corynebacterium diphtheriae NCTC 13129 riboflavin biosynthesis protein NP_938509.1 93040 D 257309 CDS NP_938510.1 38232743 2650624 94403..94822 1 NC_002935.2 Similar to Staphylococcus aureus subsp aureus N315 hypothetical protein SA2163 TR:Q99RQ4 (EMBL:AP003137) (143 aa) fasta scores: E(): 2.4e-15, 39.16% id in 143 aa; hypothetical protein 94822 2650624 DIP0114 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938510.1 94403 D 257309 CDS NP_938511.1 38232744 2648477 complement(94809..95876) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 39.2 kDa protein SCH24.21c TR:Q9X8T5 (EMBL:AL049826) (360 aa) fasta scores: E(): 5e-111, 79.49% id in 356 aa; hypothetical protein 95876 2648477 DIP0115 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938511.1 94809 R 257309 CDS NP_938512.1 38232745 2650180 complement(96123..96881) 1 NC_002935.2 Similar to Rhizobium loti MLR6622 protein TR:Q988S0 (EMBL:AP003009) (231 aa) fasta scores: E(): 1.4e-25, 40.99% id in 222 aa; hypothetical protein 96881 2650180 DIP0116 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938512.1 96123 R 257309 CDS NP_938513.1 38232746 2650181 complement(96976..97758) 1 NC_002935.2 Similar to Streptomyces coelicolor secreted lipase SCI11.24c TR:Q9S295 (EMBL:AL096849) (290 aa) fasta scores: E(): 6.8e-20, 33.18% id in 223 aa, and to Pseudomonas sp lipase precursor Lip SW:LIP_PSES5 (P25275) (364 aa) fasta scores: E(): 5.6e-05, 28.4% id in 176 aa; lipase 97758 2650181 DIP0117 Corynebacterium diphtheriae NCTC 13129 lipase NP_938513.1 96976 R 257309 CDS NP_938514.1 38232747 2650182 97855..98433 1 NC_002935.2 Similar to Thermus aquaticus NADH dehydrogenase Nox SW:NOX_THETH (Q60049) (205 aa) fasta scores: E(): 3.2e-07, 34.18% id in 196 aa; dehydrogenase 98433 2650182 DIP0118 Corynebacterium diphtheriae NCTC 13129 dehydrogenase NP_938514.1 97855 D 257309 CDS NP_938515.1 38232748 2650183 complement(98438..100177) 1 NC_002935.2 Similar to Deinococcus radiodurans ATP-dependent DNA helicase RecG-related protein DR2199 TR:Q9RSC6 (EMBL:AE002053) (596 aa) fasta scores: E(): 8.9e-13, 24.04% id in 445 aa; hypothetical protein 100177 2650183 DIP0119 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938515.1 98438 R 257309 CDS NP_938516.1 38232749 2650571 <100588..100722 1 NC_002935.2 Similar to parts of Mycobacterium smegmatis TnpA protein TR:Q50440 (EMBL:M76495) (413 aa) fasta scores: E(): 0.8, 44.44% id in 36 aa; transposon (partial) 100722 2650571 DIP0121 Corynebacterium diphtheriae NCTC 13129 transposon (partial) NP_938516.1 <100588 D 257309 CDS NP_938517.1 38232750 2650572 101238..101792 1 NC_002935.2 Similar to Streptomyces coelicolor siderophore binding protein SCBAC36F5.26 TR:CAC42862 (EMBL:AL592292) (178 aa) fasta scores: E(): 6.3e-25, 48.48% id in 165 aa; siderophore binding protein 101792 2650572 DIP0122 Corynebacterium diphtheriae NCTC 13129 siderophore binding protein NP_938517.1 101238 D 257309 CDS NP_938518.1 38232751 2650573 complement(101789..102787) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 46.1 kDa protein Rv0485 or MT0503 or MTCY20G9.11 SW:Y485_MYCTU (Q11151) (438 aa) fasta scores: E(): 1.4e-12, 32.14% id in 224 aa; hypothetical protein 102787 2650573 DIP0123 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938518.1 101789 R 257309 CDS NP_938519.1 38232752 2650515 103155..104525 1 NC_002935.2 Similar to Streptomyces coelicolor integral membrane protein SCBAC19F3.14 TR:CAC44337 (EMBL:AL596102) (517 aa) fasta scores: E(): 3.6e-47, 37.96% id in 453 aa; hypothetical protein 104525 2650515 DIP0124 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938519.1 103155 D 257309 CDS NP_938520.1 38232753 2650516 104676..105761 1 NC_002935.2 Similar to the C-terminal region of Pseudomonas aeruginosa hypothetical protein PA4923 SW:YDC3_PSEAE (P48636) (195 aa) fasta scores: E(): 3.3e-27, 44.97% id in 189 aa; hypothetical protein 105761 2650516 DIP0125 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938520.1 104676 D 257309 CDS NP_938521.1 38232754 2650517 105773..107386 1 NC_002935.2 Similar to Streptomyces coelicolor conserved hypothetical protein SCBAC36F5.07 TR:CAC42843 (EMBL:AL592292) (562 aa) fasta scores: E(): 3.6e-40, 35.62% id in 553 aa; hypothetical protein 107386 2650517 DIP0126 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938521.1 105773 D 257309 CDS NP_938522.1 38232755 2650518 107390..107860 1 NC_002935.2 Similar to Streptomyces coelicolor regulatory protein SCE50.15 TR:Q9L048 (EMBL:AL163672) (168 aa) fasta scores: E(): 3.3e-18, 41.89% id in 148 aa; MarR family transcriptional regulator 107860 2650518 DIP0127 Corynebacterium diphtheriae NCTC 13129 MarR family transcriptional regulator NP_938522.1 107390 D 257309 CDS NP_938523.1 38232756 2650519 complement(107838..108890) 1 NC_002935.2 Similar to Escherichia coli AbrB protein or B0715 SW:ABRB_ECOLI (P75747) (348 aa) fasta scores: E(): 3.6e-20, 30.72% id in 345 aa; hypothetical protein 108890 2650519 DIP0128 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938523.1 107838 R 257309 CDS NP_938524.1 38232757 2650509 complement(108895..109479) 1 NC_002935.2 hypothetical protein 109479 2650509 DIP0129 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938524.1 108895 R 257309 CDS NP_938525.1 38232758 2650510 109478..110248 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 26.0 kDa protein SC7A8.24c TR:Q9L2D4 (EMBL:AL137187) (260 aa) fasta scores: E(): 1e-34, 42.8% id in 257 aa; hypothetical protein 110248 2650510 DIP0130 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938525.1 109478 D 257309 CDS NP_938526.1 38232759 2650511 complement(110238..112583) 1 NC_002935.2 Similar to Escherichia coli ATP-dependent helicase HrpB or B0148 SW:HRPB_ECOLI (P37024) (809 aa) fasta scores: E(): 2.6e-40, 35.09% id in 815 aa; ATP-dependent helicase 112583 2650511 DIP0131 Corynebacterium diphtheriae NCTC 13129 ATP-dependent helicase NP_938526.1 110238 R 257309 CDS NP_938527.1 38232760 2649985 complement(112573..113142) 1 NC_002935.2 Similar to Streptomyces coelicolor sugar acetyltransferase SCBAC25F8.11c TR:CAC42146 (EMBL:AL592126) (193 aa) fasta scores: E(): 2.2e-24, 44.7% id in 170 aa, and to Escherichia coli galactoside O-acetyltransferase LacA or B0342 SWALL:THGA_ECOLI (SWALL:P07464) (203 aa) fasta scores: E(): 2.3e-21, 36.51% id in 178 aa; sugar acetyltransferase 113142 2649985 DIP0132 Corynebacterium diphtheriae NCTC 13129 sugar acetyltransferase NP_938527.1 112573 R 257309 CDS NP_938528.1 38232761 2649986 113144..113884 1 NC_002935.2 Similar to Escherichia coli alkylated DNA repair protein Alkb or AidD or B2212 SW:ALKB_ECOLI (P05050) (216 aa) fasta scores: E(): 1.4e-12, 35.02% id in 237 aa; DNA repair protein 113884 2649986 DIP0133 Corynebacterium diphtheriae NCTC 13129 DNA repair protein NP_938528.1 113144 D 257309 CDS NP_938529.1 38232762 2649987 113937..114524 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 DNA-3-methyladenine glycosidase I MT1248 TR:AAK45505 (EMBL:AE007001) (204 aa) fasta scores: E(): 8.3e-35, 52.71% id in 184 aa, and to Escherichia coli DNA-3-methyladenine glycosylase I Tag or B3549 SW:3MG1_ECOLI (P05100) (187 aa) fasta scores: E(): 1.5e-25, 44.88% id in 176 aa; DNA-repair protein 114524 2649987 DIP0134 Corynebacterium diphtheriae NCTC 13129 DNA-repair protein NP_938529.1 113937 D 257309 CDS NP_938530.1 38232763 2649988 114529..115257 1 NC_002935.2 Similar to Mycobacterium tuberculosis oxidoreductase Rv0484c or MT0502 or MTCY20G9.10c SW:Y484_MYCTU (Q11150) (251 aa) fasta scores: E(): 1.2e-45, 57.32% id in 232 aa; oxidoreductase 115257 2649988 DIP0135 Corynebacterium diphtheriae NCTC 13129 oxidoreductase NP_938530.1 114529 D 257309 CDS NP_938531.1 38232764 2648518 115518..116276 1 NC_002935.2 lipoprotein 116276 2648518 DIP0136 Corynebacterium diphtheriae NCTC 13129 lipoprotein NP_938531.1 115518 D 257309 CDS NP_938532.1 38232765 2648519 complement(116460..116687) 1 NC_002935.2 Similar to a region of Corynebacterium glutamicum Ycg4K TR:Q9EUM3 (EMBL:AF164956) (256 aa) fasta scores: E(): 9.2e-09, 75.61% id in 41 aa; hypothetical protein 116687 2648519 DIP0137 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938532.1 116460 R 257309 CDS NP_938533.1 38232766 2648520 complement(116920..117045) 1 NC_002935.2 Doubtful CDS. No significant database matches; hypothetical protein 117045 2648520 DIP0138 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938533.1 116920 R 257309 CDS NP_938534.1 38232767 2648521 complement(117050..117379) 1 NC_002935.2 hypothetical protein 117379 2648521 DIP0139 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938534.1 117050 R 257309 CDS NP_938535.1 38232768 2648759 complement(117622..>117900) 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein >117900 2648759 DIP0140 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938535.1 117622 R 257309 CDS NP_938536.1 38232769 2648760 118089..118232 1 NC_002935.2 Doubtful CDS. No significant database matches; hypothetical protein 118232 2648760 DIP0141 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938536.1 118089 D 257309 CDS NP_938537.1 38232770 2648761 118306..118980 1 NC_002935.2 hypothetical protein 118980 2648761 DIP0142 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938537.1 118306 D 257309 CDS NP_938538.1 38232771 2648763 complement(120068..120265) 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 120265 2648763 DIP0145 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938538.1 120068 R 257309 CDS NP_938539.1 38232772 2648764 120487..120867 1 NC_002935.2 integral membrane protein 120867 2648764 DIP0146 Corynebacterium diphtheriae NCTC 13129 integral membrane protein NP_938539.1 120487 D 257309 CDS NP_938540.1 38232773 2648508 120867..120974 1 NC_002935.2 Doubtful CDS. No significant database matches; lipoprotein 120974 2648508 DIP0147 Corynebacterium diphtheriae NCTC 13129 lipoprotein NP_938540.1 120867 D 257309 CDS NP_938541.1 38232774 2648510 121423..121722 1 NC_002935.2 Similar to Bacillus subtilis hypothetical 7.9 kDa protein in dnaN-recF intergenic region YaaA SW:YAAA_BACSU (P05650) (71 aa) fasta scores: E(): 2.5e-05, 44.92% id in 69 aa; hypothetical protein 121722 2648510 DIP0149 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938541.1 121423 D 257309 CDS NP_938542.1 38232775 2648511 121722..122546 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT0934.1 TR:AAK45182 (EMBL:AE006980) (257 aa) fasta scores: E(): 3.3e-32, 41.96% id in 255 aa; hypothetical protein 122546 2648511 DIP0150 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938542.1 121722 D 257309 CDS NP_938543.1 38232776 2648512 122552..122857 1 NC_002935.2 Similar to Streptomyces coelicolor conserved hypothetical protein SC10F4.36c TR:Q9F3M5 (EMBL:AL450350) (94 aa) fasta scores: E(): 8.6e-07, 38.2% id in 89 aa, and to Mycobacterium tuberculosis hypothetical 11.0 kDa protein Rv3204 or MTCY07D11.22c TR:O05862 (EMBL:Z95120) (101 aa) fasta scores: E(): 0.00013, 40% id in 95 aa; hypothetical protein 122857 2648512 DIP0151 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938543.1 122552 D 257309 CDS NP_938544.1 38232777 2648513 complement(122867..123787) 1 NC_002935.2 hypothetical protein 123787 2648513 DIP0152 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938544.1 122867 R 257309 CDS NP_938545.1 38232778 2648514 123927..124553 1 NC_002935.2 hypothetical protein 124553 2648514 DIP0153 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938545.1 123927 D 257309 CDS NP_938546.1 38232779 2650574 complement(124561..126570) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 endopeptidase, peptidase M13 MT0208 TR:AAK44429 (EMBL:AE006930) (663 aa) fasta scores: E(): 2.9e-89, 46.97% id in 662 aa; endopeptidase 126570 2650574 DIP0154 Corynebacterium diphtheriae NCTC 13129 endopeptidase NP_938546.1 124561 R 257309 CDS NP_938547.1 38232780 2650575 126599..127231 1 NC_002935.2 No significant database matches. Possible secreted protein; hypothetical protein 127231 2650575 DIP0155 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938547.1 126599 D 257309 CDS NP_938548.1 38232781 2650576 127228..128148 1 NC_002935.2 No significant database matches. Possible membrane protein; hypothetical protein 128148 2650576 DIP0156 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938548.1 127228 D 257309 CDS NP_938549.1 38232782 2650577 128138..129046 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 amino acid ABC transporter, amino acid-binding protein, MT3866 TR:AAK48230 (EMBL:AE007181) (343 aa) fasta scores: E(): 2.6e-26, 35.69% id in 311 aa; hypothetical protein 129046 2650577 DIP0157 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938549.1 128138 D 257309 CDS NP_938550.1 38232783 2650578 complement(129067..129504) 1 NC_002935.2 No significant database matches. Possible secreted protein; hypothetical protein 129504 2650578 DIP0158 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938550.1 129067 R 257309 CDS NP_938551.1 38232784 2650512 complement(129730..133155) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 arabinosyl transferase MT3902 TR:AAK48268 (EMBL:AE007183) (1098 aa) fasta scores: E(): 1.3e-49, 38.11% id in 1149 aa; transferase 133155 2650512 DIP0159 Corynebacterium diphtheriae NCTC 13129 transferase NP_938551.1 129730 R 257309 CDS NP_938552.1 38232785 2650513 complement(133148..135232) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 69.5 kDa protein CY13D12.26 Rv3792 or MTCY13D12.26 TR:P72058 (EMBL:Z80343) (643 aa) fasta scores: E(): 3.7e-53, 34.5% id in 652 aa; hypothetical protein 135232 2650513 DIP0160 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938552.1 133148 R 257309 CDS NP_938553.1 38232786 2650514 complement(135343..136104) 1 NC_002935.2 Similar to Mycobacterium leprae oxidoreductase ML0108 TR:Q9CDA5 (EMBL:AL583917) (254 aa) fasta scores: E(): 5.6e-50, 57.14% id in 252 aa; short chain dehydrogenase 136104 2650514 DIP0161 Corynebacterium diphtheriae NCTC 13129 short chain dehydrogenase NP_938553.1 135343 R 257309 CDS NP_938554.1 38232787 2648828 complement(136124..137590) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 oxidoreductase, FAD-binding MT3898 TR:AAK48263 (EMBL:AE007183) (463 aa) fasta scores: E(): 4.2e-118, 67.57% id in 478 aa; oxidoreductase, FAD-binding 137590 2648828 DIP0162 Corynebacterium diphtheriae NCTC 13129 oxidoreductase, FAD-binding NP_938554.1 136124 R 257309 CDS NP_938555.1 38232788 2648829 complement(137707..137955) 1 NC_002935.2 hypothetical protein 137955 2648829 DIP0163 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938555.1 137707 R 257309 CDS NP_938556.1 38232789 2648830 137984..138418 1 NC_002935.2 No significant database matches. Possible membrane protein; hypothetical protein 138418 2648830 DIP0164 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938556.1 137984 D 257309 CDS NP_938557.1 38232790 2648831 138415..138963 1 NC_002935.2 hypothetical protein 138963 2648831 DIP0165 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938557.1 138415 D 257309 CDS NP_938558.1 38232791 2648573 138975..139394 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 13.4 kDa protein Rv3789 or MT3897 or MTCY13D12.23 SW:Y1I9_MYCTU (P72055) (121 aa) fasta scores: E(): 4.2e-17, 48.78% id in 123 aa; hypothetical protein 139394 2648573 DIP0166 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938558.1 138975 D 257309 CDS NP_938559.1 38232792 2648574 139604..140383 1 NC_002935.2 No significant database matches. Note: Also similar to DIP2059 (271 aa) E(): 1e-38; 44.747% identity in 257 aa overlap; hypothetical protein 140383 2648574 DIP0167 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938559.1 139604 D 257309 CDS NP_938560.1 38232793 2648575 complement(140517..141434) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 glycosyl transferase MT3891 TR:AAK48256 (EMBL:AE007182) (304 aa) fasta scores: E(): 1.8e-71, 62.17% id in 304 aa; glycosyl transferase family protein 141434 2648575 DIP0168 Corynebacterium diphtheriae NCTC 13129 glycosyl transferase family protein NP_938560.1 140517 R 257309 CDS NP_938561.1 38232794 2648576 141608..142573 1 NC_002935.2 Similar to Treponema pallidum periplasmic zinc-binding protein TroA or TroMP1 or TP0163 SWALL:TROA_TREPA (SWALL:P96116) (308 aa) fasta scores: E(): 4.2e-29, 35.27% id in 292 aa, and to Streptococcus pneumoniae manganese ABC transporter substrate-binding lipoprotein precursor PsaA or SP1650 SWALL:P72538 (EMBL:U53509) (309 aa) fasta scores: E(): 1.6e-19, 28.47% id in 309 aa, and to Streptococcus gordonii challis coagregation-mediating adhesin precursor ScaA SW:ADHS_STRGC () (310 aa) fasta scores: E(): 1.9e-20, 30.15% id in 315 aa. Note: Also similar to the downstream DIP0173 (333 aa) E(): 6.5e-38;56.061% identity in 330 aa overlap. Contains a twin-arginine translocation (TAT) system recognition motif (RRGFIR) at the N-terminal region; hypothetical protein 142573 2648576 DIP0169 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938561.1 141608 D 257309 CDS NP_938562.1 38232795 2650622 142673..143407 1 NC_002935.2 Similar to Bacillus subtilis probable metal transport system ATP-binding protein YtgB SW:YTGB_BACSU (O34338) (250 aa) fasta scores: E(): 5.3e-33, 45.61% id in 228 aa, and to Streptococcus gordonii challis hypothetical ABC transporter ATP-binding protein in ScaA 5'region SW:YSC1_STRGC (P42360) (251 aa) fasta scores: E(): 4.6e-30, 40.26% id in 231 aa; hypothetical protein 143407 2650622 DIP0170 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938562.1 142673 D 257309 CDS NP_938563.1 38232796 2650623 143404..144303 1 NC_002935.2 Similar to Bacillus subtilis probable metal transport system membrane protein YtgC SW:YTGC_BACSU (O35024) (435 aa) fasta scores: E(): 3.1e-22, 33.91% id in 286 aa, and to Treponema pallidum zinc transport system membrane protein TroC or TP0165 SW:TROC_TREPA (P96118) (298 aa) fasta scores: E(): 1.5e-21, 35.69% id in 297 aa; hypothetical protein 144303 2650623 DIP0171 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938563.1 143404 D 257309 CDS NP_938564.1 38232797 2650437 144300..145151 1 NC_002935.2 Similar to Treponema pallidum zinc transport system membrane protein Trod or TP0166 SW:TROD_TREPA (P96119) (367 aa) fasta scores: E(): 3.4e-27, 35.97% id in 278 aa, and to Bacillus subtilis YtgD TR:O34500 (EMBL:AF008220) (295 aa) fasta scores: E(): 2.8e-25, 35.92% id in 270 aa; hypothetical protein 145151 2650437 DIP0172 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938564.1 144300 D 257309 CDS NP_938565.1 38232798 2650438 145272..146273 1 NC_002935.2 Similar to Neisseria meningitidis periplasmic binding protein NMA0789 SWALL:Q9JVL4 (EMBL:AL162754) (308 aa) fasta scores: E(): 2.7e-24, 31.71% id in 309 aa, and to Treponema pallidum periplasmic zinc-binding protein TroA or TroMP1 or TP0163 SWALL:TROA_TREPA (SWALL:P96116) (308 aa) fasta scores: E(): 2.5e-16, 33.12% id in 317 aa, and to Streptococcus pyogenes zinc-binding protein precursor AdcA or SPY0714 SWALL:Q9A0L9 (EMBL:AE006523) (515 aa) fasta scores: E(): 2.5e-16, 28.85% id in 298 aa Note: Also similar to the upstream DIP0169, (321 aa) E(): 4.5e-38; 56.798% identity in 331 aa overlap; hypothetical protein 146273 2650438 DIP0173 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938565.1 145272 D 257309 CDS NP_938566.1 38232799 2649041 complement(146339..147118) 1 NC_002935.2 Similar to Mycobacterium leprae ABC transporter ATP-binding component ML0114 SWALL:Q9CDA0 (EMBL:AL583917) (272 aa) fasta scores: E(): 2.3e-60, 74.4% id in 254 aa, and to Xylella fastidiosa ABC transporter ATP-binding protein XF2568 SWALL:Q9PAF0 (EMBL:AE004064) (246 aa) fasta scores: E(): 1.4e-34, 45.93% id in 246 aa; ABC transporter ATP-binding protein 147118 2649041 DIP0174 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_938566.1 146339 R 257309 CDS NP_938567.1 38232800 2649042 complement(147137..147997) 1 NC_002935.2 Similar to Mycobacterium leprae ABC transporter component ML0112 SWALL:Q9CDA2 (EMBL:AL583917) (276 aa) fasta scores: E(): 1.2e-60, 55.23% id in 277 aa, and to Xylella fastidiosa ABC transporter permease XF2567 SWALL:Q9PAF1 (EMBL:AE004064) (267 aa) fasta scores: E(): 5.2e-37, 36.5% id in 263 aa; ABC transporter permease 147997 2649042 DIP0175 Corynebacterium diphtheriae NCTC 13129 ABC transporter permease NP_938567.1 147137 R 257309 CDS NP_938568.1 38232801 2649043 148133..149326 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical protein ML0117 TR:Q9CD97 (EMBL:AL583917) (398 aa) fasta scores: E(): 8.1e-38, 35.73% id in 417 aa; hypothetical protein 149326 2649043 DIP0176 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938568.1 148133 D 257309 CDS NP_938569.1 38232802 2649044 complement(149323..150270) 1 NC_002935.2 Similar to Streptomyces coelicolor quinone oxidoreductase SCGD3.24c TR:Q9XA55 (EMBL:AL096822) (326 aa) fasta scores: E(): 1.4e-57, 53.87% id in 323 aa; quinone oxidoreductase 150270 2649044 DIP0177 Corynebacterium diphtheriae NCTC 13129 quinone oxidoreductase NP_938569.1 149323 R 257309 CDS NP_938570.1 38232803 2648854 complement(150627..151661) 1 NC_002935.2 Similar to Streptomyces coelicolor histidinol-phophate aminotransferase SCD78.11 TR:Q9ZBY8 (EMBL:AL034355) (359 aa) fasta scores: E(): 6.9e-55, 49.85% id in 345 aa, and to Streptomyces tendae NikT protein TR:Q9F2E4 (EMBL:AJ250581) (440 aa) fasta scores: E(): 1.1e-42, 42.9% id in 324 aa; aminotransferase 151661 2648854 DIP0178 Corynebacterium diphtheriae NCTC 13129 aminotransferase NP_938570.1 150627 R 257309 CDS NP_938571.1 38232804 2648857 152426..154000 1 NC_002935.2 Similar to Staphylococcus aureus subsp aureus Mu50 hypothetical 57.2 kDa protein SAV1916 TR:BAB58078 (EMBL:AP003363) (520 aa) fasta scores: E(): 3.6e-71, 41.38% id in 505 aa, and to Helicobacter pylori sodium-dependent transporter HP0214 TR:O25003 (EMBL:AE000541) (552 aa) fasta scores: E(): 9.3e-34, 50.45% id in 555 aa; hypothetical protein 154000 2648857 DIP0179 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938571.1 152426 D 257309 CDS NP_938572.1 38232805 2650555 154365..154994 1 NC_002935.2 hypothetical protein 154994 2650555 DIP0180 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938572.1 154365 D 257309 CDS NP_938573.1 38232806 2650556 155099..155371 1 NC_002935.2 hypothetical protein 155371 2650556 DIP0181 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938573.1 155099 D 257309 CDS NP_938574.1 38232807 2650557 complement(155600..156826) 1 NC_002935.2 Similar to Mycobacterium phage MS6 Integrase Int TR:O55248 (EMBL:AF030986) (372 aa) fasta scores: E(): 1.5e-09, 26.48% id in 370 aa; phage integrase 156826 2650557 DIP0182 Corynebacterium diphtheriae NCTC 13129 phage integrase NP_938574.1 155600 R 257309 CDS NP_938575.1 38232808 2650558 complement(156926..157948) 1 NC_002935.2 Similar to Streptococcus pneumoniae transcriptional regulator SP1809 TR:AAK75882 (EMBL:AE007473) (383 aa) fasta scores: E(): 8.2e-14, 29.35% id in 310 aa; transcriptional regulator 157948 2650558 DIP0183 Corynebacterium diphtheriae NCTC 13129 transcriptional regulator NP_938575.1 156926 R 257309 CDS NP_938576.1 38232809 2650559 complement(157960..158523) 1 NC_002935.2 hypothetical protein 158523 2650559 DIP0184 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938576.1 157960 R 257309 CDS NP_938577.1 38232810 2650678 complement(158618..159025) 1 NC_002935.2 hypothetical protein 159025 2650678 DIP0185 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938577.1 158618 R 257309 CDS NP_938578.1 38232811 2650679 complement(159035..159196) 1 NC_002935.2 hypothetical protein 159196 2650679 DIP0186 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938578.1 159035 R 257309 CDS NP_938579.1 38232812 2650680 159639..159881 1 NC_002935.2 Similar to Pyrococcus abyssi repressor protein, PAB7155 TR:Q9V101 (EMBL:AJ248284) (73 aa) fasta scores: E(): 0.002, 36.06% id in 61 aa; transcriptional regulator 159881 2650680 DIP0187 Corynebacterium diphtheriae NCTC 13129 transcriptional regulator NP_938579.1 159639 D 257309 CDS NP_938580.1 38232813 2650681 complement(160120..160446) 1 NC_002935.2 hypothetical protein 160446 2650681 DIP0188 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938580.1 160120 R 257309 CDS NP_938581.1 38232814 2650682 160470..160961 1 NC_002935.2 hypothetical protein 160961 2650682 DIP0189 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938581.1 160470 D 257309 CDS NP_938582.1 38232815 2650683 160942..161760 1 NC_002935.2 Similar to Staphylococcus aureus prophage phiPV83 antirepressor TR:Q9MBT0 (EMBL:AB044554) (265 aa) fasta scores: E(): 1.5e-32, 42.8% id in 257 aa; anti-repressor protein 161760 2650683 DIP0190 Corynebacterium diphtheriae NCTC 13129 anti-repressor protein NP_938582.1 160942 D 257309 CDS NP_938583.1 38232816 2650684 161977..162219 1 NC_002935.2 hypothetical protein 162219 2650684 DIP0191 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938583.1 161977 D 257309 CDS NP_938584.1 38232817 2650685 162231..162455 1 NC_002935.2 No significant database matches. Possible exported protein; hypothetical protein 162455 2650685 DIP0192 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938584.1 162231 D 257309 CDS NP_938585.1 38232818 2650686 162452..162598 1 NC_002935.2 hypothetical protein 162598 2650686 DIP0193 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938585.1 162452 D 257309 CDS NP_938586.1 38232819 2650687 162606..162875 1 NC_002935.2 hypothetical protein 162875 2650687 DIP0194 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938586.1 162606 D 257309 CDS NP_938587.1 38232820 2650688 162868..163017 1 NC_002935.2 hypothetical protein 163017 2650688 DIP0195 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938587.1 162868 D 257309 CDS NP_938588.1 38232821 2650689 163014..163457 1 NC_002935.2 hypothetical protein 163457 2650689 DIP0196 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938588.1 163014 D 257309 CDS NP_938589.1 38232822 2650472 163482..163715 1 NC_002935.2 hypothetical protein 163715 2650472 DIP0197 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938589.1 163482 D 257309 CDS NP_938590.1 38232823 2650473 163814..164122 1 NC_002935.2 hypothetical protein 164122 2650473 DIP0197A Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938590.1 163814 D 257309 CDS NP_938591.1 38232824 2650474 164151..165359 1 NC_002935.2 hypothetical protein 165359 2650474 DIP0198 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938591.1 164151 D 257309 CDS NP_938592.1 38232825 2650475 165352..165966 1 NC_002935.2 hypothetical protein 165966 2650475 DIP0199 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938592.1 165352 D 257309 CDS NP_938593.1 38232826 2650476 166018..166335 1 NC_002935.2 hypothetical protein 166335 2650476 DIP0200 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938593.1 166018 D 257309 CDS NP_938594.1 38232827 2650478 168436..169686 1 NC_002935.2 C-terminal region similar to Bacteriophage BFK20 portal protein TR:Q9MBK2 (EMBL:AJ278322) (215 aa) fasta scores: E(): 1e-40, 56.45% id in 209 aa, and N-terminal region to Bacteriophage BFK20 hypothetical 24.1 kDa protein TR:Q9MBK3 (EMBL:AJ278322) (213 aa) fasta scores: E(): 3.8e-29, 41.79% id in 201 aa. Note: It seems these two bacterophage proteins have been fused into DIP0203; hypothetical protein 169686 2650478 DIP0203 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938594.1 168436 D 257309 CDS NP_938595.1 38232828 2650479 169683..170726 1 NC_002935.2 C-terminal region similar to Bacteriophage BFK20 prohead protease TR:Q9MBK0 (EMBL:AJ278322) (204 aa) fasta scores: E(): 1.1e-35, 66.46% id in 164 aa, and N-terminal region to Bacteriophage BFK20 hypothetical 18.4 kDa protein TR:Q9MBK1 (EMBL:AJ278322) (176 aa) fasta scores: E(): 6.2e-14, 51.06% id in 94 aa. Note: It seems these two bacterophage proteins have been fused into DIP0204; phage prohead protease 170726 2650479 DIP0204 Corynebacterium diphtheriae NCTC 13129 phage prohead protease NP_938595.1 169683 D 257309 CDS NP_938596.1 38232829 2650480 170723..171973 1 NC_002935.2 Similar to Bacteriophage BFK20 major capsid protein TR:Q9MBJ9 (EMBL:AJ278322) (428 aa) fasta scores: E(): 5e-66, 47.14% id in 420 aa; phage capsid protein 171973 2650480 DIP0205 Corynebacterium diphtheriae NCTC 13129 phage capsid protein NP_938596.1 170723 D 257309 CDS NP_938597.1 38232830 2650481 171973..172173 1 NC_002935.2 hypothetical protein 172173 2650481 DIP0206 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938597.1 171973 D 257309 CDS NP_938598.1 38232831 2649121 172195..172677 1 NC_002935.2 Similar to Bacteriophage BFK20 hypothetical 19.9 kDa protein TR:Q9MBJ8 (EMBL:AJ278322) (180 aa) fasta scores: E(): 3.6e-16, 38.46% id in 156 aa; hypothetical protein 172677 2649121 DIP0207 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938598.1 172195 D 257309 CDS NP_938599.1 38232832 2649366 172674..173036 1 NC_002935.2 hypothetical protein 173036 2649366 DIP0208 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938599.1 172674 D 257309 CDS NP_938600.1 38232833 2650444 173002..173295 1 NC_002935.2 Similar to Bacteriophage BFK20 hypothetical 10.2 kDa protein TR:Q9MBJ7 (EMBL:AJ278322) (94 aa) fasta scores: E(): 2.5e-07, 44.57% id in 83 aa; hypothetical protein 173295 2650444 DIP0208A Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938600.1 173002 D 257309 CDS NP_938601.1 38232834 2650445 173285..173662 1 NC_002935.2 Similar to Bacteriophage BFK20 hypothetical 13.7 kDa protein TR:Q9MBJ6 (EMBL:AJ278322) (126 aa) fasta scores: E(): 1.5e-11, 37.06% id in 116 aa; hypothetical protein 173662 2650445 DIP0209 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938601.1 173285 D 257309 CDS NP_938602.1 38232835 2650446 173691..174638 1 NC_002935.2 N-terminal region similar to Bacteriophage BFK20 hypothetical 13.9 kDa protein TR:Q9MBJ5 (EMBL:AJ278322) (125 aa) fasta scores: E(): 1.3e-21, 50% id in 116 aa, and C-terminal region to Bacteriophage BFK20 hypothetical 14.9 kDa protein TR:Q9MBJ4 (EMBL:AJ278322) (145 aa) fasta scores: E(): 3e-10, 37.85% id in 140 aa. Note: It seems these two bacterophage proteins have been fused into DIP0210; hypothetical protein 174638 2650446 DIP0210 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938602.1 173691 D 257309 CDS NP_938603.1 38232836 2650447 174736..175113 1 NC_002935.2 Similar to Bacteriophage BFK20 hypothetical 15.7 kDa protein TR:Q9MBJ3 (EMBL:AJ278322) (138 aa) fasta scores: E(): 3.2e-08, 37.09% id in 124 aa; hypothetical protein 175113 2650447 DIP0211 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938603.1 174736 D 257309 CDS NP_938604.1 38232837 2650448 175275..175484 1 NC_002935.2 hypothetical protein 175484 2650448 DIP0211A Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938604.1 175275 D 257309 CDS NP_938605.1 38232838 2650449 175497..181139 1 NC_002935.2 C-terminal region identical to Corynephage beta immunity-specific protein Beta241 TR:Q37919 (EMBL:L04258) (241 aa) fasta scores: E(): 3.1e-64, 100% id in 241 aa, and whole length similar to Staphylococcus aureus subspaureus Mu50 phi pvl ORF15 and 16 homologue SAV1955 TR:BAB58117 (EMBL:AP003364) (1509 aa) fasta scores: E(): 2.9e-19, 23.76% id in 1073 aa; hypothetical protein 181139 2650449 DIP0212 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938605.1 175497 D 257309 CDS NP_938606.1 38232839 2650482 181149..181901 1 NC_002935.2 Similar to the previously sequenced Corynephage beta immunity-specific protein Beta201 TR:Q37920 (EMBL:L04258) (201 aa) fasta scores: E(): 3.9e-64, 85.64% id in 202 aa. Note: there is a frameshift in the already sequenced data in from residue 167; hypothetical protein 181901 beta201 2650482 beta201 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938606.1 181149 D 257309 CDS NP_938607.1 38232840 2650483 181902..182762 1 NC_002935.2 Almost identical to previously sequenced Corynephage beta immunity-specific protein Beta286 TR:Q37921 (EMBL:L04258) (286 aa) fasta scores: E(): 1.1e-115, 99.65% id in 286 aa; hypothetical protein 182762 beta286 2650483 beta286 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938607.1 181902 D 257309 CDS NP_938608.1 38232841 2650484 182762..183877 1 NC_002935.2 Almost identical to previously sequenced Corynephage beta immunity-specific protein Beta371 beta371 TR:Q37922 (EMBL:L04258) (371 aa) fasta scores: E(): 9.9e-126, 89.75% id in 371 aa; hypothetical protein 183877 beta371 2650484 beta371 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938608.1 182762 D 257309 CDS NP_938609.1 38232842 2650485 183877..185304 1 NC_002935.2 Low similarity to N-terminal region of Bacteriophage lambda side tail fiber protein Stf SW:STF_LAMBD (P03764) (774 aa) fasta scores: E(): 0.0021, 24.28% id in 383 aa; phage tail fiber protein 185304 2650485 DIP0216 Corynebacterium diphtheriae NCTC 13129 phage tail fiber protein NP_938609.1 183877 D 257309 CDS NP_938610.1 38232843 2650486 185304..185978 1 NC_002935.2 hypothetical protein 185978 2650486 DIP0217 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938610.1 185304 D 257309 CDS NP_938611.1 38232844 2650487 186059..187498 1 NC_002935.2 C-terminal region similar to C-terminal region of Mycobacteriophage TM4 GP29 TR:Q9ZX49 (EMBL:AF068845) (547 aa) fasta scores: E(): 3.7e-35, 49.14% id in 234 aa; hypothetical protein 187498 2650487 DIP0218 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938611.1 186059 D 257309 CDS NP_938612.1 38232845 2650488 187501..187824 1 NC_002935.2 hypothetical protein 187824 2650488 DIP0219 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938612.1 187501 D 257309 CDS NP_938613.1 38232846 2650489 187830..188294 1 NC_002935.2 hypothetical protein 188294 2650489 DIP0220 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938613.1 187830 D 257309 CDS NP_938614.1 38232847 2650490 188291..188629 1 NC_002935.2 hypothetical protein 188629 2650490 DIP0221 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938614.1 188291 D 257309 CDS NP_938615.1 38232848 2650491 188979..190661 1 NC_002935.2 Identical to previously sequenced Corynephage beta diphtheria toxin precursor SW:DTX_CORBE (P00588) (567 aa) fasta scores: E(): 6.2e-216, 100% id in 560 aa, and to Corynephage omega diphtheria toxin precursor SW:DTX_COROM (P00587) (560 aa) fasta scores: E(): 1.1e-215, 99.82% id in 560 aa. Note: The start codon for DIP0222 is 7 residues downstream of the one in Corynephage beta; diphtheria toxin 190661 tox 2650491 tox Corynebacterium diphtheriae NCTC 13129 diphtheria toxin NP_938615.1 188979 D 257309 CDS NP_938616.1 38232849 2649548 190816..190992 1 NC_002935.2 hypothetical protein 190992 2649548 DIP0223 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938616.1 190816 D 257309 CDS NP_938617.1 38232850 2649549 191070..191210 1 NC_002935.2 hypothetical protein 191210 2649549 DIP0224 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938617.1 191070 D 257309 CDS NP_938618.1 38232851 2649550 191220..192626 1 NC_002935.2 N-terminal region similar to Mycobacterium tuberculosis CDC1551 polysaccharide deacetylase, MT1128 TR:AAK45386 (EMBL:AE006993) (291 aa) fasta scores: E(): 2.1e-22, 42.43% id in 205 aa; secreted polysaccharide deacetylase 192626 2649550 DIP0225 Corynebacterium diphtheriae NCTC 13129 secreted polysaccharide deacetylase NP_938618.1 191220 D 257309 CDS NP_938619.1 38232852 2648909 complement(192614..193987) 1 NC_002935.2 Similar to Streptomyces coelicolor GntR-family regulator SC5G8.04 TR:Q9KZB0 (EMBL:AL353872) (462 aa) fasta scores: E(): 8.4e-38, 36.46% id in 458 aa; GntR family transcriptional regulator 193987 2648909 DIP0226 Corynebacterium diphtheriae NCTC 13129 GntR family transcriptional regulator NP_938619.1 192614 R 257309 CDS NP_938620.1 38232853 2648727 194078..194971 1 NC_002935.2 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 194971 2648727 DIP0227 Corynebacterium diphtheriae NCTC 13129 pyridoxal biosynthesis lyase PdxS NP_938620.1 194078 D 257309 CDS NP_938621.1 38232854 2648728 194965..195522 1 NC_002935.2 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 195522 2648728 DIP0228 Corynebacterium diphtheriae NCTC 13129 glutamine amidotransferase subunit PdxT NP_938621.1 194965 D 257309 CDS NP_938622.1 38232855 2650492 complement(195519..195686) 1 NC_002935.2 hypothetical protein 195686 2650492 DIP0229 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938622.1 195519 R 257309 CDS NP_938623.1 38232856 2650494 complement(197202..197330) 1 NC_002935.2 hypothetical protein 197330 2650494 DIP0232 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938623.1 197202 R 257309 CDS NP_938624.1 38232857 2650495 complement(197338..198327) 1 NC_002935.2 Similar to Actinomyces naeslundii fimbrial associated protein TR:O05996 (EMBL:U85709) (280 aa) fasta scores: E(): 4.5e-16, 40.000% id in 215 aa, and to Staphylococcus aureus sortase SrtA TR:Q9S446 (EMBL:AF162687) (206 aa) fasta scores: E(): 1.2, 26.923% id in 156 aa. Note: Also similar to DIP0236 (312 aa) E(): 5.7e-25; 45.342% identity in 322 aa overlap, DIP2224, DIP2012 and DIP2225; fimbrial associated sortase-like protein 198327 2650495 DIP0233 Corynebacterium diphtheriae NCTC 13129 fimbrial associated sortase-like protein NP_938624.1 197338 R 257309 CDS NP_938625.1 38232858 2650496 198371..198847 1 NC_002935.2 hypothetical protein 198847 2650496 DIP0234 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938625.1 198371 D 257309 CDS NP_938626.1 38232859 2650497 198862..200334 1 NC_002935.2 Similar to Actinomyces viscosus type-1 fimbrial major subunit precursor FimP TR:Q9X4D1 (EMBL:AF106034) (535 aa) fasta scores: E(): 6.9e-16, 31.5% id in 530 aa. Note: Contains a potential sortase anchor site (LTMPG) upstream of the C-terminal region transmembrane domain; fimbrial subunit 200334 2650497 DIP0235 Corynebacterium diphtheriae NCTC 13129 fimbrial subunit NP_938626.1 198862 D 257309 CDS NP_938627.1 38232860 2650498 200435..201373 1 NC_002935.2 Similar to Actinomyces naeslundii fimbrial associated protein TR:O68213 (EMBL:AF019629) (365 aa) fasta scores: E(): 1.2e-31, 42.802% id in 257 aa, and to Staphylococcus aureus sortase SrtA TR:Q9S446 (EMBL:AF162687) (206 aa) fasta scores: E(): 0.094, 27.559% id in 127 aa. Note: Also similar to DIP0233 (329 aa) E(): 5.2e-25; 45.031% identity in 322 aa overlap. Note: Also similar to DIP2012, DIP2224 and DIP2225; fimbrial associated sortase-like protein 201373 2650498 DIP0236 Corynebacterium diphtheriae NCTC 13129 fimbrial associated sortase-like protein NP_938627.1 200435 D 257309 CDS NP_938628.1 38232861 2648871 201366..202157 1 NC_002935.2 No significant database matches. Note: Contains a potential sortase anchor site (LALTG) upstream of the C-terminal region transmembrane domain; surface anchored protein 202157 2648871 DIP0237 Corynebacterium diphtheriae NCTC 13129 surface anchored protein NP_938628.1 201366 D 257309 CDS NP_938629.1 38232862 2648872 202163..205282 1 NC_002935.2 weak similarity to Actimomyces fimbrial associated protein. Note: Contains a potential sortase anchor site (LPKTG) upstream of the C-terminal region transmembrane domain; surface-anchored fimbrial subunit 205282 2648872 DIP0238 Corynebacterium diphtheriae NCTC 13129 surface-anchored fimbrial subunit NP_938629.1 202163 D 257309 CDS NP_938630.1 38232863 2648874 complement(205903..206310) 1 NC_002935.2 hypothetical protein 206310 2648874 DIP0240 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938630.1 205903 R 257309 CDS NP_938631.1 38232864 2650628 complement(206336..206485) 1 NC_002935.2 hypothetical protein 206485 2650628 DIP0241 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938631.1 206336 R 257309 CDS NP_938632.1 38232865 2650629 complement(206740..207051) 1 NC_002935.2 Similar to Burkholderia cepacia insertion element IS401 hypothetical 12.4 kDa protein SW:YISX_BURCE (Q51647) (107 aa) fasta scores: E(): 1.6e-06, 36.78% id in 87 aa; IS element transposase 207051 2650629 DIP0242 Corynebacterium diphtheriae NCTC 13129 IS element transposase NP_938632.1 206740 R 257309 CDS NP_938633.1 38232866 2650630 complement(207298..207492) 1 NC_002935.2 hypothetical protein 207492 2650630 DIP0243 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938633.1 207298 R 257309 CDS NP_938634.1 38232867 2650631 complement(207638..208117) 1 NC_002935.2 No significant database matches. Possible secreted protein; hypothetical protein 208117 2650631 DIP0244 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938634.1 207638 R 257309 CDS NP_938635.1 38232868 2650632 complement(208253..209263) 1 NC_002935.2 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase 209263 2650632 DIP0245 Corynebacterium diphtheriae NCTC 13129 prephenate dehydrogenase NP_938635.1 208253 R 257309 CDS NP_938636.1 38232869 2650633 209301..209753 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 17.9 kDa protein Rv3753c or MTV025.10c TR:O69720 (EMBL:AL022121) (166 aa) fasta scores: E(): 1e-20, 45.57% id in 147 aa; Conserved hypothetical protein; hypothetical protein 209753 2650633 DIP0246 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938636.1 209301 D 257309 CDS NP_938637.1 38232870 2650634 209792..210235 1 NC_002935.2 Similar to Bifidobacterium longum cytosine deaminase TR:Q9F9W7 (EMBL:AF160969) (143 aa) fasta scores: E(): 1.2e-28, 53.47% id in 144 aa, and to Mycobacterium tuberculosis CDC1551 cytidine and deoxycytidylate deaminase MT3859 TR:AAK48223 (EMBL:AE007181) (152 aa) fasta scores: E(): 6.9e-28, 53.47% id in 144 aa; cytosine deaminase 210235 2650634 DIP0247 Corynebacterium diphtheriae NCTC 13129 cytosine deaminase NP_938637.1 209792 D 257309 CDS NP_938638.1 38232871 2650636 210640..211152 1 NC_002935.2 Similar to Arthrobacter spTM1 excisionase TR:Q9LCU5 (EMBL:AF042490) (174 aa) fasta scores: E(): 4.4e-21, 41.07% id in 168 aa; excisionase 211152 2650636 DIP0248 Corynebacterium diphtheriae NCTC 13129 excisionase NP_938638.1 210640 D 257309 CDS NP_938639.1 38232872 2650637 211399..211599 1 NC_002935.2 Doubtful CDS. No significant database matches; hypothetical protein 211599 2650637 DIP0249 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938639.1 211399 D 257309 CDS NP_938640.1 38232873 2650579 211613..213949 1 NC_002935.2 Similar to Streptomyces coelicolor membrane transport protein sce87.17C TR:Q9RKC1 (EMBL:AL132674) (745 aa) fasta scores: E(): 2.9e-36, 42.48% id in 798 aa; hypothetical protein 213949 2650579 DIP0250 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938640.1 211613 D 257309 CDS NP_938641.1 38232874 2650580 214616..215908 1 NC_002935.2 Similar to Archaeoglobus fulgidus queuine tRNA-ribosyltransferase Tgt or AF1485 SW:TGT_ARCFU (O28787) (403 aa) fasta scores: E(): 8.6e-40, 40.78% id in 407 aa, and to Escherichia coli queuine tRNA-ribosyltransferase Tgt or B0406 or Z0505 or ECS0457 SW:TGT_ECOLI (P19675) (375 aa) fasta scores: E(): 4.5e-13, 37.68% id in 406 aa; tRNA-ribosyltransferase 215908 2650580 DIP0251 Corynebacterium diphtheriae NCTC 13129 tRNA-ribosyltransferase NP_938641.1 214616 D 257309 CDS NP_938642.1 38232875 2650581 215918..216811 1 NC_002935.2 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase 216811 2650581 DIP0252 Corynebacterium diphtheriae NCTC 13129 glutamyl-Q tRNA(Asp) synthetase NP_938642.1 215918 D 257309 CDS NP_938643.1 38232876 2649494 216891..218279 1 NC_002935.2 Similar to Corynebacterium glutamicum gluconate permease GntP TR:Q9AL75 (EMBL:AJ296014) (463 aa) fasta scores: E(): 2.9e-113, 69.34% id in 460 aa, and to Bacillus subtilis gluconate permease GntP SW:GNTP_BACSU (P12012) (448 aa) fasta scores: E(): 4.8e-53, 38.58% id in 451 aa; gluconate permease 218279 gntP 2649494 gntP Corynebacterium diphtheriae NCTC 13129 gluconate permease NP_938643.1 216891 D 257309 CDS NP_938644.1 38232877 2649495 complement(218276..218779) 1 NC_002935.2 Similar to Streptomyces coelicolor gluconokinase SCI52.21 TR:Q9AD88 (EMBL:AL590507) (175 aa) fasta scores: E(): 4.2e-33, 60.39% id in 154 aa, and to Escherichia coli thermosensitive gluconokinase IdnK or GntV or B4268 SW:IDNK_ECOLI (P39208) (187 aa) fasta scores: E(): 3e-20, 44.15% id in 154 aa; transferase 218779 2649495 DIP0254 Corynebacterium diphtheriae NCTC 13129 transferase NP_938644.1 218276 R 257309 CDS NP_938645.1 38232878 2649496 complement(218871..219080) 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 219080 2649496 DIP0255 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938645.1 218871 R 257309 CDS NP_938646.1 38232879 2649498 219238..219384 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 219384 2649498 DIP0256 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938646.1 219238 D 257309 CDS NP_938647.1 38232880 2650432 219574..220833 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3825 TR:AAK48194 (EMBL:AE007179) (435 aa) fasta scores: E(): 5.2e-94, 55.95% id in 420 aa; hypothetical protein 220833 2650432 DIP0257 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938647.1 219574 D 257309 CDS NP_938648.1 38232881 2650433 220837..221388 1 NC_002935.2 hypothetical protein 221388 2650433 DIP0258 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938648.1 220837 D 257309 CDS NP_938649.1 38232882 2650434 221399..223522 1 NC_002935.2 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 223522 dnaX 2650434 dnaX Corynebacterium diphtheriae NCTC 13129 DNA polymerase III subunits gamma and tau NP_938649.1 221399 D 257309 CDS NP_938650.1 38232883 2650435 223595..223915 1 NC_002935.2 Similar to Mycobacterium tuberculosis protein Rv3716c or MT3819 or MTV025.064c SW:Y1B6_MYCTU (O69683) (133 aa) fasta scores: E(): 2.7e-14, 54.16% id in 96 aa; hypothetical protein 223915 2650435 DIP0260 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938650.1 223595 D 257309 CDS NP_938651.1 38232884 2650436 223919..224575 1 NC_002935.2 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 224575 recR 2650436 recR Corynebacterium diphtheriae NCTC 13129 recombination protein RecR NP_938651.1 223919 D 257309 CDS NP_938652.1 38232885 2649284 complement(224581..225333) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 cobyric acid synthase MT3816 TR:AAK48185 (EMBL:AE007178) (231 aa) fasta scores: E(): 1.3e-31, 58.13% id in 246 aa, and to Streptomyces coelicolor hypothetical 26.2 kDa protein 2SCG58.13 TR:Q9FCA0 (EMBL:AL391017) (242 aa) fasta scores: E(): 6.6e-20, 42.85% id in 252 aa; hypothetical protein 225333 2649284 DIP0262 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938652.1 224581 R 257309 CDS NP_938653.1 38232886 2649285 complement(225335..226597) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 43.4 kDa protein Rv3712 or MTV025.060 TR:O69679 (EMBL:AL022121) (413 aa) fasta scores: E(): 2.3e-86, 59.95% id in 412 aa, and to Streptomyces coelicolor ligase 2SCG58.12 TR:Q9FCA1 (EMBL:AL391017) (412 aa) fasta scores: E(): 4.3e-59, 43.03% id in 409 aa; hypothetical protein 226597 2649285 DIP0263 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938653.1 225335 R 257309 CDS NP_938654.1 38232887 2649286 complement(226618..227739) 1 NC_002935.2 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 227739 2649286 DIP0264 Corynebacterium diphtheriae NCTC 13129 DNA polymerase III subunit epsilon NP_938654.1 226618 R 257309 CDS NP_938655.1 38232888 2649287 complement(227743..228507) 1 NC_002935.2 Similar to Escherichia coli oxygen-insensitive NADPH nitroreductase NfsA or MdaA or Mda18 or B0851 SW:NFSA_ECOLI (P17117) (240 aa) fasta scores: E(): 2e-23, 36.32% id in 223 aa; nitroreductase 228507 2649287 DIP0265 Corynebacterium diphtheriae NCTC 13129 nitroreductase NP_938655.1 227743 R 257309 CDS NP_938656.2 161598679 2649288 complement(228555..230267) 1 NC_002935.2 Similar to Corynebacterium glutamicum 2-isopropylmalate synthase LeuA SW:LEU1_CORGL (P42455) (616 aa) fasta scores: E(): 2.5e-205, 83.27% id in 604 aa; 2-isopropylmalate synthase 230267 leuA 2649288 leuA Corynebacterium diphtheriae NCTC 13129 2-isopropylmalate synthase NP_938656.2 228555 R 257309 CDS NP_938657.1 38232890 2649289 230521..231552 1 NC_002935.2 Similar to Bacillus subtilis deoxyribonucleoside regulator DeoR SW:DEOR_BACSU (P39140) (313 aa) fasta scores: E(): 6.6e-43, 42.9% id in 303 aa; regulatory protein 231552 2649289 DIP0267 Corynebacterium diphtheriae NCTC 13129 regulatory protein NP_938657.1 230521 D 257309 CDS NP_938658.1 38232891 2649290 231758..232858 1 NC_002935.2 C-terminal region similar to C-terminal region of Mycobacterium tuberculosis hypothetical 58.9 kDa protein Rv2100 precursor or MT2160 or MTCY49.40 SW:YL00_MYCTU (Q10709) (550 aa) fasta scores: E(): 7.5e-09, 35.11% id in 131 aa; hypothetical protein 232858 2649290 DIP0268 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938658.1 231758 D 257309 CDS NP_938659.1 38232892 2650521 234348..235064 1 NC_002935.2 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 235064 deoD 2650521 deoD Corynebacterium diphtheriae NCTC 13129 purine nucleoside phosphorylase NP_938659.1 234348 D 257309 CDS NP_938660.1 38232893 2650522 235061..236425 1 NC_002935.2 Similar to Staphylococcus aureus SA0132 protein TR:Q99X78 (EMBL:AP003129) (450 aa) fasta scores: E(): 3.5e-67, 46.1% id in 436 aa, and to Bacillus subtilis tetracycline resistance protein TetB or Tet SW:TCRB_BACSU (P23054) (458 aa) fasta scores: E(): 1.3e-23, 26.3% id in 403 aa; antibiotic resistance protein membrane protein 236425 2650522 DIP0272 Corynebacterium diphtheriae NCTC 13129 antibiotic resistance protein membrane protein NP_938660.1 235061 D 257309 CDS NP_938661.1 38232894 2648850 236460..237116 1 NC_002935.2 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 237116 deoC 2648850 deoC Corynebacterium diphtheriae NCTC 13129 deoxyribose-phosphate aldolase NP_938661.1 236460 D 257309 CDS NP_938662.1 38232895 2648851 237124..238776 1 NC_002935.2 Similar to Streptomyces coelicolor phosphomannomutase SCK13.08c TR:Q9AD82 (EMBL:AL512667) (549 aa) fasta scores: E(): 7.9e-86, 46.75% id in 554 aa; mutase 238776 2648851 DIP0274 Corynebacterium diphtheriae NCTC 13129 mutase NP_938662.1 237124 D 257309 CDS NP_938663.1 38232896 2648852 238823..239860 1 NC_002935.2 Similar to Streptomyces coelicolor integral membrane protein 2SCI34.05 TR:Q9EWX4 (EMBL:AL445403) (396 aa) fasta scores: E(): 1.3e-08, 28.77% id in 358 aa; hypothetical protein 239860 2648852 DIP0275 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938663.1 238823 D 257309 CDS NP_938664.1 38232897 2648853 complement(239862..240698) 1 NC_002935.2 Similar to Corynebacterium glutamicum hypothetical 29.6 kDa protein in leuA-lysC intergenic region SW:YLEU_CORGL (P42459) (270 aa) fasta scores: E(): 4.6e-47, 58.18% id in 220 aa; hypothetical protein 240698 2648853 DIP0276 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938664.1 239862 R 257309 CDS NP_938665.1 38232898 2648483 240889..242154 1 NC_002935.2 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase 242154 lysC 2648483 lysC Corynebacterium diphtheriae NCTC 13129 aspartate kinase NP_938665.1 240889 D 257309 CDS NP_938666.1 38232899 2648484 242501..245743 1 NC_002935.2 Low similarity to Staphylococcus aureus Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein SdrE or SAV0563 TR:BAB56725 (EMBL:AP003359) (1141 aa) fasta scores: E(): 1.9e-05, 21.85% id in 668 aa. Note: Contains a potential sortase anchor site (LARTG) upstream of the C-terminal region transmembrane domain; surface-anchored membrane protein 245743 2648484 DIP0278 Corynebacterium diphtheriae NCTC 13129 surface-anchored membrane protein NP_938666.1 242501 D 257309 CDS NP_938667.1 38232900 2648485 246016..247047 1 NC_002935.2 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 247047 asd 2648485 asd Corynebacterium diphtheriae NCTC 13129 aspartate-semialdehyde dehydrogenase NP_938667.1 246016 D 257309 CDS NP_938668.1 38232901 2649074 complement(247054..247620) 1 NC_002935.2 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor 247620 sigC 2649074 sigC Corynebacterium diphtheriae NCTC 13129 RNA polymerase sigma factor NP_938668.1 247054 R 257309 CDS NP_938669.1 38232902 2649075 247748..249286 1 NC_002935.2 Similar to Onchocerca volvulus endobacterium catalase Cat SW:CATA_ONCVE (Q27710) (482 aa) fasta scores: E(): 8e-92, 52.24% id in 490 aa; catalase 249286 cat 2649075 cat Corynebacterium diphtheriae NCTC 13129 catalase NP_938669.1 247748 D 257309 CDS NP_938670.1 38232903 2649076 complement(249276..250334) 1 NC_002935.2 Similar to Vibrio cholerae iron (III) ABC transporter, ATP-binding protein VC0610 TR:Q9KUB3 (EMBL:AE004146) (343 aa) fasta scores: E(): 7e-18, 34.743% id in 331 aa, and to Archaeoglobus fulgidus branched-chain amino acid ABC transporter, ATP-binding protein AF0221 TR:O30018 (EMBL:AE001090) (224 aa) fasta scores: E(): 9.2e-17, 34.562% id in 217 aa; ABC transporter ATP-binding protein 250334 2649076 DIP0282 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_938670.1 249276 R 257309 CDS NP_938671.1 38232904 2649544 complement(250325..251878) 1 NC_002935.2 Similar to Treponema hyodysenteriae permease ShiD TR:O54371 (EMBL:U75349) (277 aa) fasta scores: E(): 0.0013, 21.739% id in 184 aa, and to Escherichia coli O157:H7 EDL933 transport system permease YabK TR:AAG54371 (EMBL:AE005183) (536 aa) fasta scores: E(): 0.019, 21.995% id in 441 aa; transport system permease (iron) 251878 2649544 DIP0283 Corynebacterium diphtheriae NCTC 13129 transport system permease (iron) NP_938671.1 250325 R 257309 CDS NP_938672.1 38232905 2649545 complement(251875..252876) 1 NC_002935.2 Similar to Escherichia coli O157:H7 periplasmic-iron-binding protein ECS0415 TR:BAB33838 (EMBL:AP002551) (343 aa) fasta scores: E(): 5.5e-19, 27.139% id in 339 aa, and to Actinobacillus pleuropneumoniae AfuA protein TR:Q57512 (EMBL:U05042) (346 aa) fasta scores: E(): 4.2e-16, 26.280% id in 293 aa, and to Serratia marcescens iron(III)-binding periplasmic protein precursor SfuA SW:SFUA_SERMA (P21408) (338 aa) fasta scores: E(): 0.00026, 20.000% id in 290 aa; ABC transporter 252876 2649545 DIP0284 Corynebacterium diphtheriae NCTC 13129 ABC transporter NP_938672.1 251875 R 257309 CDS NP_938673.1 38232906 2649546 complement(252957..254327) 1 NC_002935.2 Similar to Bacillus subtilis glycerol-3-phosphate transporter GlpT SW:GLPT_BACSU (P37948) (444 aa) fasta scores: E(): 1.4e-74, 45.434% id in 438 aa, and to Escherichia coli glycerol-3-phosphate transporter GlpT or B2240 SW:GLPT_ECOLI (P08194) (452 aa) fasta scores: E(): 4.2e-74, 44.295% id in 447 aa; glycerol-3-phosphate transporter 254327 2649546 DIP0285 Corynebacterium diphtheriae NCTC 13129 glycerol-3-phosphate transporter NP_938673.1 252957 R 257309 CDS NP_938674.1 38232907 2649547 complement(254456..255157) 1 NC_002935.2 Similar to Klebsiella pneumoniae phosphate regulon transcriptional regulatory protein PhoB SW:PHOB_KLEPN (P45605) (229 aa) fasta scores: E(): 1.7e-25, 40.708% id in 226 aa, to Shigella dysenteriae phosphate regulon transcriptional regulatory protein PhoB SW:PHOB_SHIDY (P45606) (229 aa) fasta scores: E(): 6.5e-25, 40.265% id in 226 aa, and to Escherichia coli phosphate regulon transcriptional regulatory protein PhoB or B0399 or Z0497 or ECS0449 SW:PHOB_ECOLI (P08402) (229 aa) fasta scores: E(): 6.5e-25, 40.265% id in 226 aa; two-component regulatory protein 255157 2649547 DIP0286 Corynebacterium diphtheriae NCTC 13129 two-component regulatory protein NP_938674.1 254456 R 257309 CDS NP_938675.1 38232908 2650421 complement(255150..255947) 1 NC_002935.2 Similar to Escherichia coli sensor protein RcsC or B2218 SW:RCSC_ECOLI (P14376) (933 aa) fasta scores: E(): 5.5e-10, 26.339% id in 224 aa, and to Pseudomonas syringae sensor protein GacS or LemA SW:GACS_PSESY (P48027) (907 aa) fasta scores: E(): 2e-09, 27.530% id in 247 aa; two-component sensor protein 255947 2650421 DIP0287 Corynebacterium diphtheriae NCTC 13129 two-component sensor protein NP_938675.1 255150 R 257309 CDS NP_938676.1 38232909 2650422 complement(256103..256405) 1 NC_002935.2 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport; monovalent cation/H+ antiporter subunit G 256405 2650422 DIP0288 Corynebacterium diphtheriae NCTC 13129 monovalent cation/H+ antiporter subunit G NP_938676.1 256103 R 257309 CDS NP_938677.1 38232910 2650423 complement(256405..256671) 1 NC_002935.2 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit F 256671 2650423 DIP0289 Corynebacterium diphtheriae NCTC 13129 monovalent cation/H+ antiporter subunit F NP_938677.1 256405 R 257309 CDS NP_938678.1 38232911 2650424 complement(256671..257048) 1 NC_002935.2 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit E 257048 2650424 DIP0290 Corynebacterium diphtheriae NCTC 13129 monovalent cation/H+ antiporter subunit E NP_938678.1 256671 R 257309 CDS NP_938679.1 38232912 2650425 complement(257051..258574) 1 NC_002935.2 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; monovalent cation/H+ antiporter subunit D 258574 2650425 DIP0291 Corynebacterium diphtheriae NCTC 13129 monovalent cation/H+ antiporter subunit D NP_938679.1 257051 R 257309 CDS NP_938680.1 38232913 2650638 complement(258574..258999) 1 NC_002935.2 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit C 258999 2650638 DIP0292 Corynebacterium diphtheriae NCTC 13129 monovalent cation/H+ antiporter subunit C NP_938680.1 258574 R 257309 CDS NP_938681.1 38232914 2650639 complement(259003..261915) 1 NC_002935.2 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit A 261915 2650639 DIP0293 Corynebacterium diphtheriae NCTC 13129 monovalent cation/H+ antiporter subunit A NP_938681.1 259003 R 257309 CDS NP_938682.1 38232915 2648773 262085..263482 1 NC_002935.2 Similar to Deinococcus radiodurans conserved hypothetical protein DR0075 TR:Q9RY75 (EMBL:AE001870) (1467 aa) fasta scores: E(): 3e-06, 27.568% id in 370 aa; hypothetical protein 263482 2648773 DIP0294 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938682.1 262085 D 257309 CDS NP_938683.1 38232916 2648774 complement(263559..264449) 1 NC_002935.2 hypothetical protein 264449 2648774 DIP0295 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938683.1 263559 R 257309 CDS NP_938684.1 38232917 2648776 complement(264827..265741) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3785 TR:AAK48152 (EMBL:AE007176) (319 aa) fasta scores: E(): 1.6e-59, 54.08% id in 294 aa; hypothetical protein 265741 2648776 DIP0296 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938684.1 264827 R 257309 CDS NP_938685.1 38232918 2648900 265769..266233 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3790 TR:AAK48157 (EMBL:AE007176) (154 aa) fasta scores: E(): 2e-23, 57.14% id in 154 aa; hypothetical protein 266233 2648900 DIP0297 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938685.1 265769 D 257309 CDS NP_938686.1 38232919 2648901 complement(266238..268622) 1 NC_002935.2 Similar to Mycobacterium leprae Pbp1 Pon1 SWALL:P72351 (EMBL:S82044) (821 aa) fasta scores: E(): 4.9e-130, 48.08% id in 757 aa, and to Mycobacterium tuberculosis CDC1551 penicillin-binding protein 1 MT3784 TR:AAK48151 (EMBL:AE007176) (810 aa) fasta scores: E(): 4.8e-134, 48.75% id in 761 aa; penicillin-binding secreted protein 268622 2648901 DIP0298 Corynebacterium diphtheriae NCTC 13129 penicillin-binding secreted protein NP_938686.1 266238 R 257309 CDS NP_938687.1 38232920 2648902 268821..269168 1 NC_002935.2 Similar to Mycobacterium tuberculosis regulatory protein Rv681c or MTV025.029c TR:O69649 (EMBL:AL022121) (100 aa) fasta scores: E(): 4.9e-22, 65.06% id in 83 aa, and to Mycobacterium tuberculosis CDC1551 WhiB-related protein MT3783 TR:AAK48150 (EMBL:AE007176) (118 aa) fasta scores: E(): 5.6e-22, 65.06% id in 83 aa; regulatory protein 269168 2648902 DIP0299 Corynebacterium diphtheriae NCTC 13129 regulatory protein NP_938687.1 268821 D 257309 CDS NP_938688.1 38232921 2648903 269209..269364 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 6.1 kDa protein SCH17.10c TR:Q9XA37 (EMBL:AL079353) (53 aa) fasta scores: E(): 5.4e-16, 85.71% id in 49 aa, and to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3780 TR:AAK48147 (EMBL:AE007175) (53 aa) fasta scores: E(): 5.9e-14, 77.08% id in 48 aa; hypothetical protein 269364 2648903 DIP0300 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938688.1 269209 D 257309 CDS NP_938689.1 38232922 2648904 269366..269830 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3779 TR:AAK48146 (EMBL:AE007175) (151 aa) fasta scores: E(): 1.3e-30, 63.75% id in 149 aa, and to Streptomyces coelicolor hypothetical 15.7 kDa protein SCH17.09c TR:Q9XA38 (EMBL:AL079353) (155 aa) fasta scores: E(): 2.5e-29, 62.25% id in 151 aa; hypothetical protein 269830 2648904 DIP0301 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938689.1 269366 D 257309 CDS NP_938690.1 38232923 2648905 269881..270705 1 NC_002935.2 Similar to Mycobacterium tuberculosis hydrolase Rv3677c or MTV025.025c TR:O69645 (EMBL:AL022121) (264 aa) fasta scores: E(): 1.1e-18, 40.89% id in 269 aa; hydrolase 270705 2648905 DIP0302 Corynebacterium diphtheriae NCTC 13129 hydrolase NP_938690.1 269881 D 257309 CDS NP_938691.1 38232924 2648906 complement(270766..271449) 1 NC_002935.2 Similar to Corynebacterium glutamicum probable transcription regulator TR:AAK58838 (EMBL:AF293334) (227 aa) fasta scores: E(): 8e-79, 91.18% id in 227 aa, and to Escherichia coli catabolite gene activator Crp or Cap or Csm or B3357 or Z4718 or ECS4208 SW:CRP_ECOLI (P03020) (210 aa) fasta scores: E(): 4.6e-15, 33.68% id in 190 aa; transcriptional regulator 271449 2648906 DIP0303 Corynebacterium diphtheriae NCTC 13129 transcriptional regulator NP_938691.1 270766 R 257309 CDS NP_938692.1 38232925 2650640 271954..272709 1 NC_002935.2 Similar to Mycobacterium tuberculosis endonuclease III Nth or Rv3674c or MT3775 or MTV025.022c SW:END3_MYCTU (O69642) (245 aa) fasta scores: E(): 2.2e-59, 62.04% id in 245 aa, and to Bacillus subtilis probable endonuclease III Nth or JooB SW:END3_BACSU (P39788) (219 aa) fasta scores: E(): 1.4e-28, 41.96% id in 193 aa; endonuclease III 272709 nth 2650640 nth Corynebacterium diphtheriae NCTC 13129 endonuclease III NP_938692.1 271954 D 257309 CDS NP_938693.1 38232926 2650641 272702..273262 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 thioredoxin-related protein MT3774 TR:AAK48141 (EMBL:AE007175) (227 aa) fasta scores: E(): 7.6e-13, 32.84% id in 204 aa; hypothetical protein 273262 2650641 DIP0305 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938693.1 272702 D 257309 CDS NP_938694.1 38232927 2650642 273265..274002 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 26.5 kDa protein SCH17.02c TR:Q9XA45 (EMBL:AL079353) (247 aa) fasta scores: E(): 1.9e-26, 40.08% id in 227 aa; hypothetical protein 274002 2650642 DIP0306 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938694.1 273265 D 257309 CDS NP_938695.1 38232928 2650643 274025..275221 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 serine protease MT3772 TR:AAK48139 (EMBL:AE007175) (397 aa) fasta scores: E(): 1.5e-47, 38.19% id in 398 aa; serine protease (mycosin) 275221 2650643 DIP0307 Corynebacterium diphtheriae NCTC 13129 serine protease (mycosin) NP_938695.1 274025 D 257309 CDS NP_938696.1 38232929 2650644 complement(275218..276156) 1 NC_002935.2 Similar to Streptomyces coelicolor hydrolase SCH5.29 TR:Q9X931 (EMBL:AL035636) (324 aa) fasta scores: E(): 5.8e-17, 31.21% id in 330 aa; hydrolase 276156 2650644 DIP0308 Corynebacterium diphtheriae NCTC 13129 hydrolase NP_938696.1 275218 R 257309 CDS NP_938697.1 38232930 2648740 complement(276244..276765) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 18.9 kDa protein Rv3669 or MTV025.017 TR:O69637 (EMBL:AL022121) (172 aa) fasta scores: E(): 1.8e-20, 51.85% id in 135 aa; hypothetical protein 276765 2648740 DIP0309 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938697.1 276244 R 257309 CDS NP_938698.1 38232931 2648741 276872..277525 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 26.4 kDa protein Rv3662c or MTV025.010c TR:O69630 (EMBL:AL022121) (256 aa) fasta scores: E(): 3.1e-07, 31.44% id in 229 aa; hypothetical protein 277525 2648741 DIP0310 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938698.1 276872 D 257309 CDS NP_938699.1 38232932 2648742 complement(277463..278368) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 30.7 kDa protein Rv3661 or MT3761 or MTV025.009 SW:Y0G1_MYCTU (O69629) (287 aa) fasta scores: E(): 2.2e-40, 45.22% id in 272 aa, and to Streptomyces coelicolor morphological differentiation-associated protein SCH5.21 TR:Q9X923 (EMBL:AL035636) (268 aa) fasta scores: E(): 5e-38, 45.8% id in 262 aa; hypothetical protein 278368 2648742 DIP0311 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938699.1 277463 R 257309 CDS NP_938700.1 38232933 2648743 278791..279828 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 35.8 kDa protein Rv3660c or MT3760 or MTV25.008c TR:O69628 (EMBL:AL022121) (350 aa) fasta scores: E(): 9.7e-19, 30.29% id in 340 aa, and to Streptomyces cyaneus (Streptomyces curacoi) inhibition of morphological differentiation TR:O33612 (EMBL:AB004855) (370 aa) fasta scores: E(): 1.6e-13, 33.08% id in 266 aa; morphological differentiation-like protein 279828 2648743 DIP0312 Corynebacterium diphtheriae NCTC 13129 morphological differentiation-like protein NP_938700.1 278791 D 257309 CDS NP_938701.1 38232934 2648744 279821..280918 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 36.7 kDa protein Rv3659c or MTV025.007c TR:O69627 (EMBL:AL022121) (352 aa) fasta scores: E(): 6.7e-51, 52.21% id in 316 aa; hypothetical protein 280918 2648744 DIP0313 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938701.1 279821 D 257309 CDS NP_938702.1 38232935 2648745 280915..281661 1 NC_002935.2 Similar to Mycobacterium tuberculosis transmembrane protein Rv3658c or MTV025.006c TR:O69626 (EMBL:AL022121) (266 aa) fasta scores: E(): 6.1e-17, 36.52% id in 230 aa; hypothetical protein 281661 2648745 DIP0314 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938702.1 280915 D 257309 CDS NP_938703.1 38232936 2648746 281661..282239 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 19.1 kDa protein Rv3657c or MTV025.005c TR:O69625 (EMBL:AL022121) (191 aa) fasta scores: E(): 2.9e-10, 36.66% id in 150 aa; hypothetical protein 282239 2648746 DIP0315 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938703.1 281661 D 257309 CDS NP_938704.1 38232937 2648747 282263..282460 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 7.1 kDa protein Rv3656c or MTV025.004c TR:O69624 (EMBL:AL022121) (68 aa) fasta scores: E(): 2.6e-05, 43.33% id in 60 aa; hypothetical protein 282460 2648747 DIP0316 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938704.1 282263 D 257309 CDS NP_938705.1 38232938 2649489 282457..282732 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 13.0 kDa protein Rv3655c or MTV025.003c TR:O69623 (EMBL:AL022121) (125 aa) fasta scores: E(): 1.4, 31.81% id in 66 aa; hypothetical protein 282732 2649489 DIP0317 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938705.1 282457 D 257309 CDS NP_938706.1 38232939 2649490 282729..283055 1 NC_002935.2 Similar to the central region of Streptomyces coelicolor membrane spanning protein SCH5.14c TR:Q9X916 (EMBL:AL035636) (230 aa) fasta scores: E(): 2.6e-05, 35.23% id in 105 aa; hypothetical protein 283055 2649490 DIP0318 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938706.1 282729 D 257309 CDS NP_938707.1 38232940 2649491 complement(283045..285381) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 ATP-dependent RNA helicase, DeaD/DeaH box family MT3751 TR:AAK48112 (EMBL:AE007173) (771 aa) fasta scores: E(): 1.3e-152, 54.73% id in 760 aa, and to Bacillus subtilis helicase YprA SW:YPRA_BACSU (P50830) (749 aa) fasta scores: E(): 4.7e-67, 34.86% id in 763 aa; ATP-dependent RNA helicase 285381 2649491 DIP0319 Corynebacterium diphtheriae NCTC 13129 ATP-dependent RNA helicase NP_938707.1 283045 R 257309 CDS NP_938708.1 38232941 2649659 285652..285855 1 NC_002935.2 Similar to Mycobacterium smegmatis cold-shock protein CspA TR:Q9KGW0 (EMBL:AF281675) (67 aa) fasta scores: E(): 5.8e-23, 86.56% id in 67 aa; cold-shock protein 285855 cspA 2649659 cspA Corynebacterium diphtheriae NCTC 13129 cold-shock protein NP_938708.1 285652 D 257309 CDS NP_938709.1 38232942 2649492 286029..286646 1 NC_002935.2 Similar to Streptomyces coelicolor ABC transporter ATP-binding protein SC4A2.02c TR:O86658 (EMBL:AL031182) (229 aa) fasta scores: E(): 6.7e-12, 39.3% id in 201 aa; ABC transporter ATP-binding protein 286646 2649492 DIP0321 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_938709.1 286029 D 257309 CDS NP_938710.1 38232943 2649493 286643..287350 1 NC_002935.2 Similar to Escherichia coli hypothetical ABC transporter ATP-binding protein YddO or B1483 SW:YDDO_ECOLI (P77622) (308 aa) fasta scores: E(): 1.7e-15, 36.36% id in 209 aa; ABC transporter ATP-binding protein 287350 2649493 DIP0322 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_938710.1 286643 D 257309 CDS NP_938711.1 38232944 2649674 287347..288594 1 NC_002935.2 Similar to Streptomyces coelicolor transport system permease sc4g2.20 TR:O86692 (EMBL:AL031371) (436 aa) fasta scores: E(): 4.5e-47, 42.61% id in 406 aa; ABC transporter 288594 2649674 DIP0323 Corynebacterium diphtheriae NCTC 13129 ABC transporter NP_938711.1 287347 D 257309 CDS NP_938712.1 38232945 2649675 288591..290078 1 NC_002935.2 Similar to Streptomyces coelicolor solute-binding lipoprotein SC4G2.18 TR:O86690 (EMBL:AL031371) (503 aa) fasta scores: E(): 1.3e-64, 39.63% id in 497 aa; hypothetical protein 290078 2649675 DIP0324 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938712.1 288591 D 257309 CDS NP_938713.1 38232946 2649676 290085..291839 1 NC_002935.2 Similar to Streptomyces coelicolor transport system permease SC4G2.19 TR:O86691 (EMBL:AL031371) (601 aa) fasta scores: E(): 1.9e-62, 37.01% id in 570 aa; transport system membrane protein 291839 2649676 DIP0325 Corynebacterium diphtheriae NCTC 13129 transport system membrane protein NP_938713.1 290085 D 257309 CDS NP_938714.1 38232947 2649677 complement(291817..293310) 1 NC_002935.2 Similar to Streptomyces coelicolor oxidoreductase SCF43A.31 TR:Q9XA84 (EMBL:AL096837) (520 aa) fasta scores: E(): 7.8e-84, 44.21% id in 484 aa; hypothetical protein 293310 2649677 DIP0326 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938714.1 291817 R 257309 CDS NP_938715.1 38232948 2649678 293451..296345 1 NC_002935.2 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 296345 topA 2649678 topA Corynebacterium diphtheriae NCTC 13129 DNA topoisomerase I NP_938715.1 293451 D 257309 CDS NP_938716.1 38232949 2649280 complement(296265..297290) 1 NC_002935.2 Similar to Streptococcus pneumoniae Pap2 family protein SP0489 TR:AAK74647 (EMBL:AE007360) (216 aa) fasta scores: E(): 2.3e-06, 30.43% id in 207 aa; hypothetical protein 297290 2649280 DIP0328 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938716.1 296265 R 257309 CDS NP_938717.1 38232950 2649281 complement(297398..299374) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 opt family protein MT2465 TR:AAK46760 (EMBL:AE007086) (667 aa) fasta scores: E(): 3.6e-138, 61.18% id in 644 aa; OPT family protein. membrane protein 299374 2649281 DIP0329 Corynebacterium diphtheriae NCTC 13129 OPT family protein. membrane protein NP_938717.1 297398 R 257309 CDS NP_938718.1 38232951 2649282 complement(299461..301524) 1 NC_002935.2 C-terminal region similar to Micromonospora viridifaciens sialidase precursor NedA SW:NANH_MICVI (Q02834) (647 aa) fasta scores: E(): 1.8e-23, 34.24% id in 403 aa; hypothetical protein 301524 2649282 DIP0330 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938718.1 299461 R 257309 CDS NP_938719.1 38232952 2649283 301604..302503 1 NC_002935.2 Similar to Klebsiella oxytoca YiaX1 TR:AAK69523 (EMBL:AF282849) (315 aa) fasta scores: E(): 4.4e-18, 31.94% id in 313 aa; hypothetical protein 302503 2649283 DIP0331 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938719.1 301604 D 257309 CDS NP_938720.1 38232953 2650453 complement(302520..304046) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 adenylate cyclase, MT3748 TR:AAK48108 (EMBL:AE007173) (549 aa) fasta scores: E(): 5.4e-73, 42.99% id in 507 aa; adenylate cyclase 304046 2650453 DIP0332 Corynebacterium diphtheriae NCTC 13129 adenylate cyclase NP_938720.1 302520 R 257309 CDS NP_938721.1 38232954 2650454 304045..305310 1 NC_002935.2 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 305310 2650454 DIP0333 Corynebacterium diphtheriae NCTC 13129 DNA polymerase III subunit delta' NP_938721.1 304045 D 257309 CDS NP_938722.1 38232955 2650456 305695..305946 1 NC_002935.2 hypothetical protein 305946 2650456 DIP0334 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938722.1 305695 D 257309 CDS NP_938723.1 38232956 2650457 306195..306602 1 NC_002935.2 hypothetical protein 306602 2650457 DIP0335 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938723.1 306195 D 257309 CDS NP_938724.1 38232957 2650458 complement(306606..306815) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 8.5 kDa protein Rv1055 or MTV017.08 TR:O53403 (EMBL:AL021897) (78 aa) fasta scores: E(): 0.00013, 45.16% id in 62 aa; hypothetical protein 306815 2650458 DIP0336 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938724.1 306606 R 257309 CDS NP_938725.1 38232958 2650459 complement(306912..307370) 1 NC_002935.2 Low similarity to bacteriophage BIL309 Integrase Int TR:Q9AZR0 (EMBL:AF323670) (377 aa) fasta scores: E(): 0.45, 27.41% id in 124 aa; phage integrase 307370 2650459 DIP0337 Corynebacterium diphtheriae NCTC 13129 phage integrase NP_938725.1 306912 R 257309 CDS NP_938726.1 38232959 2650460 complement(307437..307559) 1 NC_002935.2 hypothetical protein 307559 2650460 DIP0338 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938726.1 307437 R 257309 CDS NP_938727.1 38232960 2650461 complement(307596..307805) 1 NC_002935.2 hypothetical protein 307805 2650461 DIP0339 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938727.1 307596 R 257309 CDS NP_938728.1 38232961 2650463 308897..309421 1 NC_002935.2 hypothetical protein 309421 2650463 DIP0343 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938728.1 308897 D 257309 CDS NP_938729.1 38232962 2650464 309428..309568 1 NC_002935.2 hypothetical protein 309568 2650464 DIP0344 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938729.1 309428 D 257309 CDS NP_938730.1 38232963 2650465 309574..309753 1 NC_002935.2 hypothetical protein 309753 2650465 DIP0345 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938730.1 309574 D 257309 CDS NP_938731.1 38232964 2648858 309772..309933 1 NC_002935.2 Similar to Escherichia coli transposase InsI for insertion sequence element IS30B/C/D (InsI1 or B0256) and (InsI2 or B1404) and (InsI3 or B4284) SW:INSI_ECOLI (P37246) (383 aa) fasta scores: E(): 0.72, 45.45% id in 44 aa; IS element tranposase (partial) 309933 2648858 DIP0346 Corynebacterium diphtheriae NCTC 13129 IS element tranposase (partial) NP_938731.1 309772 D 257309 CDS NP_938732.1 38232965 2648859 309946..310104 1 NC_002935.2 hypothetical protein 310104 2648859 DIP0347 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938732.1 309946 D 257309 CDS NP_938733.1 38232966 2648860 complement(310129..311286) 1 NC_002935.2 Similar to Neisseria meningitidis hypothetical protein NMB0459 TR:Q9K0V1 (EMBL:AE002402) (369 aa) fasta scores: E(): 1.8e-58, 45.47% id in 365 aa; hypothetical protein 311286 2648860 DIP0348 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938733.1 310129 R 257309 CDS NP_938734.1 38232967 2648861 311422..312120 1 NC_002935.2 Similar to Streptomyces coelicolor DNA repair protein SCG20A.20c TR:Q9K3M0 (EMBL:AL360055) (216 aa) fasta scores: E(): 1.4e-27, 44.54% id in 220 aa, and to Escherichia coli alkylated DNA repair protein AlkB or AidD or B2212 SW:ALKB_ECOLI (P05050) (216 aa) fasta scores: E(): 5.6e-10, 32.46% id in 231 aa; alkylated DNA repair protein 312120 2648861 DIP0349 Corynebacterium diphtheriae NCTC 13129 alkylated DNA repair protein NP_938734.1 311422 D 257309 CDS NP_938735.1 38232968 2648862 complement(312169..312993) 1 NC_002935.2 Similar to Streptomyces coelicolor hydrolase SCBAC14E8.01c TR:Q9ADJ8 (EMBL:AL590435) (228 aa) fasta scores: E(): 1.6e-05, 28.49% id in 186 aa; protease 312993 2648862 DIP0350 Corynebacterium diphtheriae NCTC 13129 protease NP_938735.1 312169 R 257309 CDS NP_938736.1 38232969 2648863 313246..313617 1 NC_002935.2 Low similarity to central part of Corynebacterium glutamicum replicase RepA TR:Q9EUN5 (EMBL:AF164956) (479 aa) fasta scores: E(): 1.8e-16, 56.86% id in 102 aa; plasmid replication protein 313617 2648863 DIP0351 Corynebacterium diphtheriae NCTC 13129 plasmid replication protein NP_938736.1 313246 D 257309 CDS NP_938737.1 38232970 2648864 complement(313721..313888) 1 NC_002935.2 Similar to Clostridium perfringens hypothetical 6.1 kDa protein SW:YPI8_CLOPE (P18018) (55 aa) fasta scores: E(): 1, 42.85% id in 35 aa; hypothetical protein 313888 2648864 DIP0352 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938737.1 313721 R 257309 CDS NP_938738.1 38232971 2648865 complement(313903..314421) 1 NC_002935.2 Similar to N-terminal region of Streptococcus pneumoniae 3-hydroxy-3-methylglutaryl-CoA reductase SP1726 TR:AAK75803 (EMBL:AE007465) (424 aa) fasta scores: E(): 8.7, 26.38% id in 144 aa; hypothetical protein 314421 2648865 DIP0353 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938738.1 313903 R 257309 CDS NP_938739.1 38232972 2648867 complement(315605..315754) 1 NC_002935.2 hypothetical protein 315754 2648867 DIP0356 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938739.1 315605 R 257309 CDS NP_938740.1 38232973 2648868 316102..323838 1 NC_002935.2 C-terminal region Similar to Deinococcus radiodurans alpha-dextran endo-1,6-alpha-glucosidase DR0405 TR:Q9RXB0 (EMBL:AE001900) (910 aa) fasta scores: E(): 3.1e-110, 41.4% id in 942 aa, and N-terminal region similar to Streptomyces lividans alpha-amylase precursor Amy SW:AMY_STRLI (Q05884) (919 aa) fasta scores: E(): 1.4e-86, 41.56% id in 676 aa; bifunctional alpha-amylase/endo-alpha-glucosidase 323838 2648868 DIP0357 Corynebacterium diphtheriae NCTC 13129 bifunctional alpha-amylase/endo-alpha-glucosidase NP_938740.1 316102 D 257309 CDS NP_938741.1 38232974 2648869 complement(323875..325527) 1 NC_002935.2 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 325527 2648869 DIP0358 Corynebacterium diphtheriae NCTC 13129 acyl-CoA synthetase NP_938741.1 323875 R 257309 CDS NP_938742.1 38232975 2648870 325657..326445 1 NC_002935.2 Low similarity to Streptomyces scabies esterase precursor EstA SW:ESTA_STRSC (P22266) (345 aa) fasta scores: E(): 0.12, 26.28% id in 331 aa; secreted hydrolase 326445 2648870 DIP0359 Corynebacterium diphtheriae NCTC 13129 secreted hydrolase NP_938742.1 325657 D 257309 CDS NP_938743.1 38232976 2648843 complement(326409..327281) 1 NC_002935.2 Similar to Escherichia coli glucose-1-phosphate thymidylyltransferase RfbA SW:RBA2_ECOLI (P55253) (293 aa) fasta scores: E(): 1.5e-64, 59.93% id in 287 aa; glucose-1-phosphate thymidylyltransferase 327281 rfbA 2648843 rfbA Corynebacterium diphtheriae NCTC 13129 glucose-1-phosphate thymidylyltransferase NP_938743.1 326409 R 257309 CDS NP_938744.1 38232977 2648844 complement(327293..328639) 1 NC_002935.2 N-terminal region similar to Streptococcus pneumoniae dTDP-4-keto-6-deoxyglucose-3,5-epimerase CPS19AM TR:Q9Z642 (EMBL:AF105113) (197 aa) fasta scores: E(): 2.5e-29, 51.68% id in 178 aa, and C-terminal region to Serratia marcescens dTDP-L-rhamnose synthase RmlD TR:O52480 (EMBL:AF038816) (288 aa) fasta scores: E(): 6.7e-28, 38.79% id in 281 aa; bifunctional protein GlmU 328639 2648844 DIP0361 Corynebacterium diphtheriae NCTC 13129 bifunctional protein GlmU NP_938744.1 327293 R 257309 CDS NP_938745.1 38232978 2648845 complement(328678..329685) 1 NC_002935.2 Similar to Mycobacterium leprae dTDP-(glucose or rhamnose)-4,6-dehydratase RmlB TR:Q9X7A3 (EMBL:AL049491) (331 aa) fasta scores: E(): 8.3e-84, 63.77% id in 334 aa; dTDP-(glucose or rhamnose)-4,6-dehydratase 329685 rmlB 2648845 rmlB Corynebacterium diphtheriae NCTC 13129 dTDP-(glucose or rhamnose)-4,6-dehydratase NP_938745.1 328678 R 257309 CDS NP_938746.1 38232979 2648846 complement(329691..331043) 1 NC_002935.2 Similar to Streptomyces coelicolor metallopeptidase SCD95A.06c TR:Q9KXW8 (EMBL:AL357432) (473 aa) fasta scores: E(): 5.2e-42, 32.16% id in 457 aa; metallopeptidase 331043 2648846 DIP0363 Corynebacterium diphtheriae NCTC 13129 metallopeptidase NP_938746.1 329691 R 257309 CDS NP_938747.1 38232980 2648847 complement(331040..333034) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 prolyl oligopeptidase MT0473 TR:AAK44697 (EMBL:AE006950) (673 aa) fasta scores: E(): 9.6e-118, 46.64% id in 671 aa; prolyl oligopeptidase 333034 2648847 DIP0364 Corynebacterium diphtheriae NCTC 13129 prolyl oligopeptidase NP_938747.1 331040 R 257309 CDS NP_938748.1 38232981 2648848 complement(333123..334190) 1 NC_002935.2 Similar to Corynebacterium ammoniagenes surface layer protein A SlpA TR:BAB62413 (EMBL:AB055224) (358 aa) fasta scores: E(): 1.4e-69, 52.76% id in 362 aa, and to Mycobacterium tuberculosis antigen 85-A precursor FbpA or MPT44 or Rv3804c or MT3911 or MTV026.09c SW:A85A_MYCTU (P17944) (338 aa) fasta scores: E(): 9.7e-18, 31.56% id in 320 aa; surface layer protein A 334190 slpA 2648848 slpA Corynebacterium diphtheriae NCTC 13129 surface layer protein A NP_938748.1 333123 R 257309 CDS NP_938749.1 38232982 2648849 complement(334217..334318) 1 NC_002935.2 Doubtful CDS. No significant database matches; hypothetical protein 334318 2648849 DIP0366 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938749.1 334217 R 257309 CDS NP_938750.1 38232983 2650450 complement(334359..334622) 1 NC_002935.2 hypothetical protein 334622 2650450 DIP0367 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938750.1 334359 R 257309 CDS NP_938751.1 38232984 2650451 334658..336067 1 NC_002935.2 E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component; dihydrolipoamide dehydrogenase 336067 lpd 2650451 lpd Corynebacterium diphtheriae NCTC 13129 dihydrolipoamide dehydrogenase NP_938751.1 334658 D 257309 CDS NP_938752.1 38232985 2650452 complement(336275..337699) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 DNA-binding protein, MT0481 TR:AAK44705 (EMBL:AE006950) (474 aa) fasta scores: E(): 2.8e-101, 55.34% id in 477 aa; regulatory protein 337699 2650452 DIP0369 Corynebacterium diphtheriae NCTC 13129 regulatory protein NP_938752.1 336275 R 257309 CDS NP_938753.1 38232986 2648883 338150..338908 1 NC_002935.2 Low similarity to Bacillus pseudofirmus succinate dehydrogenease cytochrome B-558 subunit DhsC SWALL:O54447 (EMBL:U91843) (159 aa) fasta scores: E(): 0.011, 28.22% id in 163 aa, and to Streptomyces coelicolor cytochrome B subunit SCM10.12c TR:Q9RCY6 (EMBL:AL133469) (243 aa) fasta scores: E(): 1.8e-18, 36.01% id in 236 aa; succinate dehydrogenease cytochrome B subunit 338908 2648883 DIP0370 Corynebacterium diphtheriae NCTC 13129 succinate dehydrogenease cytochrome B subunit NP_938753.1 338150 D 257309 CDS NP_938754.1 38232987 2648884 338927..340942 1 NC_002935.2 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 340942 sdhA 2648884 sdhA Corynebacterium diphtheriae NCTC 13129 succinate dehydrogenase flavoprotein subunit NP_938754.1 338927 D 257309 CDS NP_938755.1 38232988 2648885 340942..341691 1 NC_002935.2 catalyzes the reversible formation of fumarate and ubiquinol from succinate and ubiquinone; succinate dehydrogenase/fumarate reductase iron-sulfur subunit 341691 2648885 DIP0372 Corynebacterium diphtheriae NCTC 13129 succinate dehydrogenase/fumarate reductase iron-sulfur subunit NP_938755.1 340942 D 257309 CDS NP_938756.1 38232989 2648886 341769..342119 1 NC_002935.2 hypothetical protein 342119 2648886 DIP0373 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938756.1 341769 D 257309 CDS NP_938757.1 38232990 2648887 342204..342299 1 NC_002935.2 hypothetical protein 342299 2648887 DIP0374 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938757.1 342204 D 257309 CDS NP_938758.1 38232991 2648888 342318..343586 1 NC_002935.2 Similar to Mycobacterium tuberculosis membrane protein Rv0473 or MTV038.17 TR:O53758 (EMBL:AL021933) (456 aa) fasta scores: E(): 2.5e-69, 44.47% id in 416 aa; hypothetical protein 343586 2648888 DIP0375 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938758.1 342318 D 257309 CDS NP_938759.1 38232992 2648889 343599..343874 1 NC_002935.2 Similar to Streptomyces coelicolor membrane protein 2SCD46.14 TR:Q9FCG9 (EMBL:AL391406) (113 aa) fasta scores: E(): 0.0064, 32.14% id in 84 aa; hypothetical protein 343874 2648889 DIP0376 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938759.1 343599 D 257309 CDS NP_938760.1 38232993 2648890 343881..344369 1 NC_002935.2 hypothetical protein 344369 2648890 DIP0377 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938760.1 343881 D 257309 CDS NP_938761.1 38232994 2648891 complement(344366..345109) 1 NC_002935.2 hypothetical protein 345109 2648891 DIP0378 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938761.1 344366 R 257309 CDS NP_938762.1 38232995 2648892 complement(345115..345990) 1 NC_002935.2 Similar to Clostridium pasteurianum pyruvate formate-lyase ativating enzyme Act SW:PFLA_CLOPA (Q46267) (238 aa) fasta scores: E(): 1.4e-32, 44.24% id in 226 aa, and to Escherichia coli pyruvate formate-lyase 1 activating enzyme PflA or Act or B0902 or Z1246 or ECS0985 SW:PFLA_ECOLI (P09374) (245 aa) fasta scores: E(): 1.1e-31, 38.68% id in 243 aa; oxidoreductase 345990 2648892 DIP0379 Corynebacterium diphtheriae NCTC 13129 oxidoreductase NP_938762.1 345115 R 257309 CDS NP_938763.1 38232996 2648801 complement(348818..349630) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 29.8 kDa protein 2SCD46.17c TR:Q9FCG6 (EMBL:AL391406) (271 aa) fasta scores: E(): 3e-26, 47.92% id in 265 aa; hypothetical protein 349630 2648801 DIP0382 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938763.1 348818 R 257309 CDS NP_938764.1 38232997 2648802 complement(349646..350107) 1 NC_002935.2 Low similarity to Mycobacterium tuberculosis hypothetical 19.1 kDa protein Rv0481c or MT0499 or MTCY20G9.07c SW:Y481_MYCTU (Q11147) (174 aa) fasta scores: E(): 0.028, 23.92% id in 163 aa; hypothetical protein 350107 2648802 DIP0383 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938764.1 349646 R 257309 CDS NP_938765.1 38232998 2648803 350143..351276 1 NC_002935.2 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 351276 murB 2648803 murB Corynebacterium diphtheriae NCTC 13129 UDP-N-acetylenolpyruvoylglucosamine reductase NP_938765.1 350143 D 257309 CDS NP_938766.1 38232999 2648804 complement(351273..351638) 1 NC_002935.2 Similar to Bacillus subtilis YjqA protein TR:O34593 (EMBL:Z99110) (125 aa) fasta scores: E(): 5e-11, 35.51% id in 107 aa; hypothetical protein 351638 2648804 DIP0385 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938766.1 351273 R 257309 CDS NP_938767.1 38233000 2648805 complement(351641..353347) 1 NC_002935.2 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 353347 2648805 DIP0386 Corynebacterium diphtheriae NCTC 13129 long-chain-fatty-acid--CoA ligase NP_938767.1 351641 R 257309 CDS NP_938768.1 38233001 2648806 complement(353409..355109) 1 NC_002935.2 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 355109 2648806 DIP0387 Corynebacterium diphtheriae NCTC 13129 long-chain-fatty-acid--CoA ligase NP_938768.1 353409 R 257309 CDS NP_938769.1 38233002 2650670 355193..356476 1 NC_002935.2 Similar to Streptomyces coelicolor glycosyl transferase GlgA TR:Q9X9U5 (EMBL:AJ243803) (387 aa) fasta scores: E(): 3.5e-19, 29.88% id in 415 aa and to Mycobacterium leprae hypothetical 45.3 kDa protein ML2443 or U2168f or B2168_c2_201 SW:Y486_MYCLE (P54138) (428 aa) fasta scores: E(): 1.3e-73, 52.23% id in 402 aa; glycosyl transferase family protein 356476 2650670 DIP0388 Corynebacterium diphtheriae NCTC 13129 glycosyl transferase family protein NP_938769.1 355193 D 257309 CDS NP_938770.1 38233003 2650671 356496..357281 1 NC_002935.2 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 357281 gpmA 2650671 gpmA Corynebacterium diphtheriae NCTC 13129 phosphoglyceromutase NP_938770.1 356496 D 257309 CDS NP_938771.1 38233004 2650672 357293..358447 1 NC_002935.2 Similar to Mycobacterium tuberculosis sensor-like histidine kinase SenX3 or Rv0490 or MT0509 or MTCY20G9.16 SW:SEX3_MYCTU (Q11155) (410 aa) fasta scores: E(): 3.6e-60, 48.84% id in 389 aa; two component system sensor kinase 358447 2650672 DIP0390 Corynebacterium diphtheriae NCTC 13129 two component system sensor kinase NP_938771.1 357293 D 257309 CDS NP_938772.1 38233005 2650673 358447..359127 1 NC_002935.2 Similar to Mycobacterium tuberculosis sensory transduction protein RegX3 or Rv0491 or MT0510 or MTCY20G9.17 SW:RGX3_MYCTU (Q11156) (227 aa) fasta scores: E(): 4e-68, 80.97% id in 226 aa; two component system response regulator 359127 regX3 2650673 regX3 Corynebacterium diphtheriae NCTC 13129 two component system response regulator NP_938772.1 358447 D 257309 CDS NP_938773.1 38233006 2650674 complement(359090..359959) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 32.9 kDa protein Rv0495c or MT0515 or MTCY20G9.21c SW:Y495_MYCTU (Q11160) (296 aa) fasta scores: E(): 3.6e-25, 44.07% id in 270 aa; hypothetical protein 359959 2650674 DIP0392 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938773.1 359090 R 257309 CDS NP_938774.1 38233007 2650675 360212..360835 1 NC_002935.2 hypothetical protein 360835 2650675 DIP0393 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938774.1 360212 D 257309 CDS NP_938775.1 38233008 2650676 360869..361681 1 NC_002935.2 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 361681 proC 2650676 proC Corynebacterium diphtheriae NCTC 13129 pyrroline-5-carboxylate reductase NP_938775.1 360869 D 257309 CDS NP_938776.1 38233009 2650677 361938..362129 1 NC_002935.2 Similar to Mycobacterium leprae B2168_C1_172 ML2429 TR:Q49828 (EMBL:U00018) (86 aa) fasta scores: E(): 7.6e-16, 80% id in 55 aa; excisionase 362129 2650677 DIP0395 Corynebacterium diphtheriae NCTC 13129 excisionase NP_938776.1 361938 D 257309 CDS NP_938777.1 38233010 2650200 362191..362418 1 NC_002935.2 Similar to Mycobacterium tuberculosis and Mycobacterium leprae hypothetical 4.1 kDa protein Rv0500.1/ML2428.1 or Rv0500B or MT0521.1 or ML2428.1 or ML2428A SW:Y50A_MYCTU (Q9CB56) (33 aa) fasta scores: E(): 1.6e-08, 100% id in 33 aa; hypothetical protein 362418 2650200 DIP0396 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938777.1 362191 D 257309 CDS NP_938778.1 38233011 2650201 362497..363366 1 NC_002935.2 Similar to Streptomyces coelicolor membrane protein SCBAC16H6.28 TR:CAC44607 (EMBL:AL596162) (270 aa) fasta scores: E(): 4.9e-22, 39.13% id in 207 aa; hypothetical protein 363366 2650201 DIP0397 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938778.1 362497 D 257309 CDS NP_938779.1 38233012 2650202 complement(363332..364375) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 32.7 kDa protein Rv0505c or MT0526 or MTCY20G9.32c SW:Y505_MYCTU (Q11169) (308 aa) fasta scores: E(): 4.7e-52, 59.67% id in 243 aa; hypothetical protein 364375 2650202 DIP0398 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938779.1 363332 R 257309 CDS NP_938780.1 38233013 2650203 364441..364683 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 10.7 kDa protein Rv0508 or MT0529 or MTCY20G9.35 SW:Y508_MYCTU (Q11172) (97 aa) fasta scores: E(): 2.7e-08, 40.74% id in 81 aa; hypothetical protein 364683 2650203 DIP0399 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938780.1 364441 D 257309 CDS NP_938781.1 38233014 2650204 364800..366116 1 NC_002935.2 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 366116 hemA 2650204 hemA Corynebacterium diphtheriae NCTC 13129 glutamyl-tRNA reductase NP_938781.1 364800 D 257309 CDS NP_938782.1 38233015 2650205 366113..366997 1 NC_002935.2 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 366997 hemC 2650205 hemC Corynebacterium diphtheriae NCTC 13129 porphobilinogen deaminase NP_938782.1 366113 D 257309 CDS NP_938783.1 38233016 2650206 367058..368728 1 NC_002935.2 Similar to Mycobacterium leprae possible uroporphyrin-III C-methyltransferase HemD or ML2420 TR:Q9CB60 (EMBL:AL583925) (563 aa) fasta scores: E(): 9.3e-91, 52.81% id in 551 aa; uroporphyrin-III C-methyltransferase 368728 2650206 DIP0402 Corynebacterium diphtheriae NCTC 13129 uroporphyrin-III C-methyltransferase NP_938783.1 367058 D 257309 CDS NP_938784.1 38233017 2650207 368725..369717 1 NC_002935.2 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 369717 hemB 2650207 hemB Corynebacterium diphtheriae NCTC 13129 delta-aminolevulinic acid dehydratase NP_938784.1 368725 D 257309 CDS NP_938785.1 38233018 2649504 complement(369844..370155) 1 NC_002935.2 hypothetical protein 370155 2649504 DIP0404 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938785.1 369844 R 257309 CDS NP_938786.1 38233019 2649505 370197..372722 1 NC_002935.2 Similar to Mycobacterium tuberculosis probable cation-transporting ATPase V CtpV or Rv0969 or MT0997 or MTCY10D7.05c SW:CTPV_MYCTU (P77894) (770 aa) fasta scores: E(): 4.5e-29, 27.6% id in 797 aa; cation transport protein 372722 2649505 DIP0405 Corynebacterium diphtheriae NCTC 13129 cation transport protein NP_938786.1 370197 D 257309 CDS NP_938787.1 38233020 2649506 complement(372700..373818) 1 NC_002935.2 Low similarity to Bacillus halodurans BH0756 protein TR:Q9KEU3 (EMBL:AP001509) (410 aa) fasta scores: E(): 1.4e-07, 23.95% id in 405 aa; hypothetical protein 373818 2649506 DIP0406 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938787.1 372700 R 257309 CDS NP_938788.1 38233021 2649507 373884..374918 1 NC_002935.2 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 374918 hemE 2649507 hemE Corynebacterium diphtheriae NCTC 13129 uroporphyrinogen decarboxylase NP_938788.1 373884 D 257309 CDS NP_938789.1 38233022 2649508 374934..376286 1 NC_002935.2 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX; protoporphyrinogen oxidase 376286 hemG 2649508 hemG Corynebacterium diphtheriae NCTC 13129 protoporphyrinogen oxidase NP_938789.1 374934 D 257309 CDS NP_938790.1 38233023 2649362 376342..377634 1 NC_002935.2 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 377634 hemL 2649362 hemL Corynebacterium diphtheriae NCTC 13129 glutamate-1-semialdehyde aminotransferase NP_938790.1 376342 D 257309 CDS NP_938791.1 38233024 2649363 377631..378239 1 NC_002935.2 Similar to Streptomyces coelicolor phosphoglycerate mutase SCD65.13 TR:Q9F2R9 (EMBL:AL392176) (233 aa) fasta scores: E(): 1.5e-35, 50.25% id in 199 aa and low similarity to Escherichia coli probable phosphoglycerate mutase 2 GpmB or B4395 or Z5997 or ECS5353 SW:PMG2_ECOLI (P36942) (215 aa) fasta scores: E(): 8.5e-06, 25.96% id in 181 aa; phosphoglycerate mutase 378239 2649363 DIP0410 Corynebacterium diphtheriae NCTC 13129 phosphoglycerate mutase NP_938791.1 377631 D 257309 CDS NP_938792.1 38233025 2649364 378240..378800 1 NC_002935.2 Similar to Deinococcus radiodurans thiol:disulfide interchange protein DR0189 TR:Q9RXW6 (EMBL:AE001881) (185 aa) fasta scores: E(): 7.1e-09, 34.84% id in 132 aa, and to Bacillus halodurans thioredoxin BH1522 TR:Q9KCP7 (EMBL:AP001512) (177 aa) fasta scores: E(): 3.4e-08, 34.12% id in 126 aa and to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT0548 TR:AAK44771 (EMBL:AE006954) (216 aa) fasta scores: E(): 9.2e-31, 48.95% id in 192 aa; electron transport-like protein 378800 2649364 DIP0411 Corynebacterium diphtheriae NCTC 13129 electron transport-like protein NP_938792.1 378240 D 257309 CDS NP_938793.1 38233026 2649365 378797..379588 1 NC_002935.2 Similar to Mycobacterium leprae B2168_C1_192 ML2411 TR:Q49810 (EMBL:U00018) (262 aa) fasta scores: E(): 8.6e-46, 53.2% id in 250 aa; cytochrome C biogenesis protein 379588 2649365 DIP0412 Corynebacterium diphtheriae NCTC 13129 cytochrome C biogenesis protein NP_938793.1 378797 D 257309 CDS NP_938794.1 38233027 2648570 379597..381189 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 57.1 kDa protein Rv0528 or MTCY25D10.07 TR:O06394 (EMBL:Z95558) (529 aa) fasta scores: E(): 3.9e-103, 49.43% id in 532 aa; hypothetical protein 381189 2648570 DIP0413 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938794.1 379597 D 257309 CDS NP_938795.1 38233028 2648571 381198..382097 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 cytochrome C assembly family protein MT0551 TR:AAK44774 (EMBL:AE006954) (324 aa) fasta scores: E(): 6.3e-54, 47.81% id in 320 aa; cytochrome C-like protein 382097 2648571 DIP0414 Corynebacterium diphtheriae NCTC 13129 cytochrome C-like protein NP_938795.1 381198 D 257309 CDS NP_938796.1 38233029 2648572 complement(382094..382363) 1 NC_002935.2 Similar to Streptomyces coelicolor ArsR-family transcriptional regulator SC4A9.07 TR:Q9L1V5 (EMBL:AL138668) (117 aa) fasta scores: E(): 7.2e-10, 44.57% id in 83 aa, and to Methanococcus jannaschii hypothetical protein MJ1325 TR:Q58721 (EMBL:U67573) (89 aa) fasta scores: E(): 5.1e-09, 42.16% id in 83 aa; ArsR family transcriptional regulator 382363 2648572 DIP0415 Corynebacterium diphtheriae NCTC 13129 ArsR family transcriptional regulator NP_938796.1 382094 R 257309 CDS NP_938797.1 38233030 2650527 complement(382403..382591) 1 NC_002935.2 Low similarity to Mycobacterium tuberculosis CDC1551 hypothetical 6.1 kDa protein MT0553 TR:AAK44776 (EMBL:AE006954) (53 aa) fasta scores: E(): 4, 34.04% id in 47 aa; hypothetical protein 382591 2650527 DIP0416 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938797.1 382403 R 257309 CDS NP_938798.1 38233031 2650528 382590..382931 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT0554 TR:AAK44777 (EMBL:AE006954) (105 aa) fasta scores: E(): 3.1e-05, 35.8% id in 81 aa; hypothetical protein 382931 2650528 DIP0417 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938798.1 382590 D 257309 CDS NP_938799.1 38233032 2650529 complement(382906..383769) 1 NC_002935.2 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 383769 menA 2650529 menA Corynebacterium diphtheriae NCTC 13129 1,4-dihydroxy-2-naphthoate octaprenyltransferase NP_938799.1 382906 R 257309 CDS NP_938800.1 38233033 2650530 383911..385020 1 NC_002935.2 Low similarity in parts to Mycobacterium tuberculosis hypothetical 58.9 kDa protein precursor Rv2100 or MT2160 or MTCY49.40 SW:YL00_MYCTU (Q10709) (550 aa) fasta scores: E(): 1.7e-06, 32.57% id in 132 aa; hypothetical protein 385020 2650530 DIP0419 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938800.1 383911 D 257309 CDS NP_938801.1 38233034 2650531 complement(384980..386089) 1 NC_002935.2 Similar to Mycobacterium leprae O-succinylbenzoic acid-CoA ligase MenE or ML2257 TR:Q9CBB8 (EMBL:AL583924) (368 aa) fasta scores: E(): 7.1e-41, 43.71% id in 366 aa, and to Escherichia coli O-succinylbenzoic acid--CoA ligase MenE or B2260 SW:MENE_ECOLI (P37353) (451 aa) fasta scores: E(): 8.2e-14, 29.28% id in 379 aa; O-succinylbenzoic acid--CoA ligase 386089 2650531 DIP0420 Corynebacterium diphtheriae NCTC 13129 O-succinylbenzoic acid--CoA ligase NP_938801.1 384980 R 257309 CDS NP_938802.1 38233035 2650532 complement(386100..386966) 1 NC_002935.2 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 386966 menB 2650532 menB Corynebacterium diphtheriae NCTC 13129 naphthoate synthase NP_938802.1 386100 R 257309 CDS NP_938803.1 38233036 2649095 386971..387933 1 NC_002935.2 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 387933 menC 2649095 menC Corynebacterium diphtheriae NCTC 13129 O-succinylbenzoate synthase NP_938803.1 386971 D 257309 CDS NP_938804.1 38233037 2649096 387917..389446 1 NC_002935.2 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 389446 2649096 DIP0423 Corynebacterium diphtheriae NCTC 13129 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase NP_938804.1 387917 D 257309 CDS NP_938805.1 38233038 2649097 389443..389835 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 18.7 kDa protein Rv0556 or MTCY25D10.35 TR:O06422 (EMBL:Z95558) (171 aa) fasta scores: E(): 1.2e-11, 42.14% id in 121 aa; hypothetical protein 389835 2649097 DIP0424 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938805.1 389443 D 257309 CDS NP_938806.1 38233039 2649098 389811..390836 1 NC_002935.2 Similar to Agrobacterium tumefaciens Agr_C_4173p TR:AAK88039 (EMBL:AE008145) (363 aa) fasta scores: E(): 1.9e-22, 31.8% id in 305 aa; glycosyl transferase family protein 390836 2649098 DIP0425 Corynebacterium diphtheriae NCTC 13129 glycosyl transferase family protein NP_938806.1 389811 D 257309 CDS NP_938807.2 161598678 2649099 390814..391503 1 NC_002935.2 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 391503 ubiE 2649099 ubiE Corynebacterium diphtheriae NCTC 13129 ubiquinone/menaquinone biosynthesis methyltransferase NP_938807.2 390814 D 257309 CDS NP_938808.1 38233041 2649100 complement(391490..392440) 1 NC_002935.2 Similar to Clostridium acetobutylicum lactate dehydrogenase CAC3552 TR:AAK81477 (EMBL:AE007851) (320 aa) fasta scores: E(): 1.6e-36, 38.6% id in 316 aa, and to Bacillus subtilis L-lactate dehydrogenase Ldh or LctE SW:LDH_BACSU (P13714) (320 aa) fasta scores: E(): 2.9e-25, 33.95% id in 324 aa; lactate dehydrogenase 392440 2649100 DIP0427 Corynebacterium diphtheriae NCTC 13129 lactate dehydrogenase NP_938808.1 391490 R 257309 CDS NP_938809.1 38233042 2649101 complement(392451..393653) 1 NC_002935.2 Similar to Mycobacterium leprae FAD-linked oxidoreductase ML2276 TR:Q9CBA6 (EMBL:AL583925) (408 aa) fasta scores: E(): 7.2e-61, 54.47% id in 391 aa; FAD-linked oxidoreductase 393653 2649101 DIP0428 Corynebacterium diphtheriae NCTC 13129 FAD-linked oxidoreductase NP_938809.1 392451 R 257309 CDS NP_938810.1 38233043 2650502 393735..394727 1 NC_002935.2 Similar to Mycobacterium leprae polyprenyl diphosphate synthase component ML2277 TR:Q9CBA5 (EMBL:AL583925) (330 aa) fasta scores: E(): 1.6e-57, 51.69% id in 325 aa, and to Bacillus stearothermophilus heptaprenyl diphosphate synthase component II HepT or HepS-2 SW:HEP2_BACST (P55785) (320 aa) fasta scores: E(): 9.6e-33, 38.99% id in 318 aa; polyprenyl diphosphate synthase component 394727 2650502 DIP0429 Corynebacterium diphtheriae NCTC 13129 polyprenyl diphosphate synthase component NP_938810.1 393735 D 257309 CDS NP_938811.1 38233044 2650507 395376..395744 1 NC_002935.2 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 395744 secE 2650507 secE Corynebacterium diphtheriae NCTC 13129 preprotein translocase subunit SecE NP_938811.1 395376 D 257309 CDS NP_938812.1 38233045 2650508 395838..396629 1 NC_002935.2 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 396629 nusG 2650508 nusG Corynebacterium diphtheriae NCTC 13129 transcription antitermination protein NusG NP_938812.1 395838 D 257309 CDS NP_938813.1 38233046 2650582 396774..397202 1 NC_002935.2 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 397202 rplK 2650582 rplK Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L11 NP_938813.1 396774 D 257309 CDS NP_938814.1 38233047 2650583 397269..397976 1 NC_002935.2 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 397976 rplA 2650583 rplA Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L1 NP_938814.1 397269 D 257309 CDS NP_938815.1 38233048 2650584 complement(398031..398843) 1 NC_002935.2 Similar to Escherichia coli transposase InsK for insertion sequence element IS150 or B3558 SW:INSK_ECOLI (P19769) (283 aa) fasta scores: E(): 1.3e-42, 44.48% id in 263 aa. Identical to DIP1517, DIP1526, DIP1809 and DIP2123; transposase 398843 2650584 DIP0434 Corynebacterium diphtheriae NCTC 13129 transposase NP_938815.1 398031 R 257309 CDS NP_938816.1 38233049 2650585 complement(398891..399373) 1 NC_002935.2 Similar to Streptococcus pneumoniae hypothetical 20.7 kDa protein TR:Q9KK22 (EMBL:AF154034) (171 aa) fasta scores: E(): 1.1e-07, 32.69% id in 156 aa, and to Yersinia pestis insertion element IS1661 DNA-binding protein YPO4046 TR:CAC93502 (EMBL:AJ414160) (171 aa) fasta scores: E(): 0.00096, 26.06% id in 165 aa. Identical to DIP1518, DIP1525, DIP1808 and DIP2124; insertion element DNA-binding protein 399373 2650585 DIP0435 Corynebacterium diphtheriae NCTC 13129 insertion element DNA-binding protein NP_938816.1 398891 R 257309 CDS NP_938817.1 38233050 2650586 399728..400243 1 NC_002935.2 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 400243 rplJ 2650586 rplJ Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L10 NP_938817.1 399728 D 257309 CDS NP_938818.1 38233051 2650587 400287..400667 1 NC_002935.2 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 400667 rplL 2650587 rplL Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L7/L12 NP_938818.1 400287 D 257309 CDS NP_938819.1 38233052 2650588 400793..402262 1 NC_002935.2 C-terminal similar to Bacillus halodurans surface adhesin A precursor PsaA or BH0516 TR:Q9KFG3 (EMBL:AP001508) (300 aa) fasta scores: E(): 2.9e-14, 34.09% id in 176 aa; hypothetical protein 402262 2650588 DIP0438 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938819.1 400793 D 257309 CDS NP_938820.1 38233053 2650589 402263..403159 1 NC_002935.2 No significant database matches. Note: Also presents similarities with DIP1724, DIP0442, DIP2325 and DIP0443; hypothetical protein 403159 2650589 DIP0439 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938820.1 402263 D 257309 CDS NP_938821.1 38233054 2649660 403152..403880 1 NC_002935.2 Similar to Deinococcus radiodurans manganese ABC transporter, ATP-binding protein, DR2284 TR:Q9RS43 (EMBL:AE002060) (239 aa) fasta scores: E(): 5.3e-25, 39.57% id in 235 aa; ABC transporter ATP-binding protein 403880 2649660 DIP0440 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_938821.1 403152 D 257309 CDS NP_938822.1 38233055 2649661 403882..404745 1 NC_002935.2 Similar to Streptococcus gordonii challis 29 kDa membrane protein in psaA 5'region SW:P29K_STRGC (P42361) (278 aa) fasta scores: E(): 3.8e-28, 38.25% id in 264 aa; hypothetical protein 404745 2649661 DIP0441 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938822.1 403882 D 257309 CDS NP_938823.1 38233056 2649662 404738..406720 1 NC_002935.2 No significant database matches. Note: Also similar to DIP0439, DIP1724, DIP2325 and DIP0443; hypothetical protein 406720 2649662 DIP0442 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938823.1 404738 D 257309 CDS NP_938824.1 38233057 2649663 406738..407592 1 NC_002935.2 No significant database matches. Note: Contains a potential sortase anchor site (LPDTG) upstream of the C-terminal region transmembrane domain. Also similar to DIP0439, DIP1724, DIP0442 and DIP2325; surface-anchored membrane protein 407592 2649663 DIP0443 Corynebacterium diphtheriae NCTC 13129 surface-anchored membrane protein NP_938824.1 406738 D 257309 CDS NP_938825.1 38233058 2649664 407597..408616 1 NC_002935.2 No significant database matches. Contains a lysine rich region close to the C-terminal end; hypothetical protein 408616 2649664 DIP0444 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938825.1 407597 D 257309 CDS NP_938826.1 38233059 2649665 408621..409559 1 NC_002935.2 Low similarity to Mycobacterium leprae integral membrane protein ML2581 TR:Q9CD18 (EMBL:AL583926) (427 aa) fasta scores: E(): 2.5, 24.7% id in 344 aa; hypothetical protein 409559 2649665 DIP0445 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938826.1 408621 D 257309 CDS NP_938827.1 38233060 2650616 409723..413250 1 NC_002935.2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 413250 rpoB 2650616 rpoB Corynebacterium diphtheriae NCTC 13129 DNA-directed RNA polymerase subunit beta NP_938827.1 409723 D 257309 CDS NP_938828.1 38233061 2650617 413298..417308 1 NC_002935.2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 417308 rpoC 2650617 rpoC Corynebacterium diphtheriae NCTC 13129 DNA-directed RNA polymerase subunit beta' NP_938828.1 413298 D 257309 CDS NP_938829.1 38233062 2650618 complement(417620..418336) 1 NC_002935.2 Similar to Streptomyces coelicolor ABC transport system ATP-binding protein SCE41.20c TR:Q9F2N9 (EMBL:AL442120) (262 aa) fasta scores: E(): 2.4e-29, 44.49% id in 236 aa; ABC transporter ATP-binding protein 418336 2650618 DIP0448 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_938829.1 417620 R 257309 CDS NP_938830.1 38233063 2650619 complement(418336..420009) 1 NC_002935.2 Low similarity to Staphylococcus aureus, ABC transporter VraE or SA2493 or SAV2702 TR:Q9KWJ6 (EMBL:AB035452) (626 aa) fasta scores: E(): 0.066, 21.03% id in 385 aa; ABC transporter inner membrane protein 420009 2650619 DIP0449 Corynebacterium diphtheriae NCTC 13129 ABC transporter inner membrane protein NP_938830.1 418336 R 257309 CDS NP_938831.1 38233064 2650620 420167..420643 1 NC_002935.2 hypothetical protein 420643 2650620 DIP0450 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938831.1 420167 D 257309 CDS NP_938832.1 38233065 2650621 420648..420971 1 NC_002935.2 hypothetical protein 420971 2650621 DIP0451 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938832.1 420648 D 257309 CDS NP_938833.1 38233066 2650590 complement(421023..421292) 1 NC_002935.2 Low similarity to Corynebacterium jeikeium transposase A TnpA TR:AAK67709 (EMBL:AY036070) (105 aa) fasta scores: E(): 0.17, 32.63% id in 95 aa; transposase 421292 2650590 DIP0452 Corynebacterium diphtheriae NCTC 13129 transposase NP_938833.1 421023 R 257309 CDS NP_938834.1 38233067 2650592 complement(426702..427061) 1 NC_002935.2 Low similarity to Pseudomonas aeruginosa probable transcriptional regulator PA3689 TR:Q9HXV1 (EMBL:AE004788) (156 aa) fasta scores: E(): 2.1, 34.34% id in 99 aa; hypothetical protein 427061 2650592 DIP0455 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938834.1 426702 R 257309 CDS NP_938835.1 38233068 2650593 complement(427246..427710) 1 NC_002935.2 hypothetical protein 427710 2650593 DIP0456 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938835.1 427246 R 257309 CDS NP_938836.1 38233069 2650594 complement(427803..428210) 1 NC_002935.2 hypothetical protein 428210 2650594 DIP0457 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938836.1 427803 R 257309 CDS NP_938837.1 38233070 2650595 428385..429611 1 NC_002935.2 Almost identical to already sequenced Corynebacterium diphtheriae histidine kinase CstS TR:Q9RPE8 (EMBL:AF161328) (408 aa) fasta scores: E(): 2e-149, 97.3% id in 408 aa; histidine kinase 429611 cstS 2650595 cstS Corynebacterium diphtheriae NCTC 13129 histidine kinase NP_938837.1 428385 D 257309 CDS NP_938838.1 38233071 2650596 429616..430317 1 NC_002935.2 Identical to previously sequenced Corynebacterium diphtheriae response regulator CstA TR:Q9RPE7 (EMBL:AF161328) (233 aa) fasta scores: E(): 4.9e-83, 99.57% id in 233 aa; response regulator 430317 cstA 2650596 cstA Corynebacterium diphtheriae NCTC 13129 response regulator NP_938838.1 429616 D 257309 CDS NP_938839.1 38233072 2650597 430344..431318 1 NC_002935.2 Similar to Streptomyces coelicolor ABC transporter ATP-binding subunit 2SC6G5.39c TR:Q9K4B6 (EMBL:AL359152) (346 aa) fasta scores: E(): 9.6e-39, 44.02% id in 318 aa; ABC transporter ATP-binding protein 431318 2650597 DIP0460 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_938839.1 430344 D 257309 CDS NP_938840.1 38233073 2648752 431339..432106 1 NC_002935.2 Low similarity to Streptomyces coelicolor integral membrane protein SCBAC17A6.12c TR:CAC44657 (EMBL:AL596248) (387 aa) fasta scores: E(): 0.021, 30.04% id in 213 aa; ABC transporter inner membrane protein 432106 2648752 DIP0461 Corynebacterium diphtheriae NCTC 13129 ABC transporter inner membrane protein NP_938840.1 431339 D 257309 CDS NP_938841.1 38233074 2648753 432122..432793 1 NC_002935.2 hypothetical protein 432793 2648753 DIP0462 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938841.1 432122 D 257309 CDS NP_938842.1 38233075 2648754 432790..433728 1 NC_002935.2 Similar to Streptococcus pyogenes hypothetical protein SPY0576 TR:Q9A0X1 (EMBL:AE006514) (300 aa) fasta scores: E(): 2.3e-31, 36.93% id in 287 aa; hypothetical protein 433728 2648754 DIP0463 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938842.1 432790 D 257309 CDS NP_938843.1 38233076 2648755 complement(433725..434228) 1 NC_002935.2 Low similarity to the central part of Alcaligenes eutrophus NrdG protein TR:Q9ZER3 (EMBL:AJ012479) (256 aa) fasta scores: E(): 6.4e-13, 37.5% id in 168 aa; hypothetical protein 434228 2648755 DIP0464 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938843.1 433725 R 257309 CDS NP_938844.1 38233077 2648756 complement(434314..436098) 1 NC_002935.2 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 436098 2648756 DIP0465 Corynebacterium diphtheriae NCTC 13129 anaerobic ribonucleoside triphosphate reductase NP_938844.1 434314 R 257309 CDS NP_938845.1 38233078 2648757 436256..436609 1 NC_002935.2 hypothetical protein 436609 2648757 DIP0466 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938845.1 436256 D 257309 CDS NP_938846.1 38233079 2648758 436884..437255 1 NC_002935.2 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 437255 rpsL 2648758 rpsL Corynebacterium diphtheriae NCTC 13129 30S ribosomal protein S12 NP_938846.1 436884 D 257309 CDS NP_938847.1 38233080 2649090 437259..437726 1 NC_002935.2 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 437726 rpsG 2649090 rpsG Corynebacterium diphtheriae NCTC 13129 30S ribosomal protein S7 NP_938847.1 437259 D 257309 CDS NP_938848.1 38233081 2649091 437925..440105 1 NC_002935.2 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 440105 fusA 2649091 fusA Corynebacterium diphtheriae NCTC 13129 elongation factor G NP_938848.1 437925 D 257309 CDS NP_938849.1 38233082 2649092 440423..441613 1 NC_002935.2 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 441613 tuf 2649092 tuf Corynebacterium diphtheriae NCTC 13129 elongation factor Tu NP_938849.1 440423 D 257309 CDS NP_938850.1 38233083 2649093 441718..442248 1 NC_002935.2 Similar to N-terminal region of Bacillus halodurans BH2297 protein TR:Q9KAJ0 (EMBL:AP001515) (232 aa) fasta scores: E(): 1.5e-08, 30.82% id in 146 aa; hypothetical protein 442248 2649093 DIP0471 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938850.1 441718 D 257309 CDS NP_938851.1 38233084 2649094 442760..443065 1 NC_002935.2 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 443065 rpsJ 2649094 rpsJ Corynebacterium diphtheriae NCTC 13129 30S ribosomal protein S10 NP_938851.1 442760 D 257309 CDS NP_938852.1 38233085 2649032 443098..443754 1 NC_002935.2 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 443754 rplC 2649032 rplC Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L3 NP_938852.1 443098 D 257309 CDS NP_938853.1 38233086 2649033 443751..444404 1 NC_002935.2 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 444404 rplD 2649033 rplD Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L4 NP_938853.1 443751 D 257309 CDS NP_938854.1 38233087 2649034 444404..444709 1 NC_002935.2 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 444709 rplW 2649034 rplW Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L23 NP_938854.1 444404 D 257309 CDS NP_938855.1 38233088 2649035 444731..445573 1 NC_002935.2 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 445573 rplB 2649035 rplB Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L2 NP_938855.1 444731 D 257309 CDS NP_938856.1 38233089 2649036 445590..445868 1 NC_002935.2 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 445868 rpsS 2649036 rpsS Corynebacterium diphtheriae NCTC 13129 30S ribosomal protein S19 NP_938856.1 445590 D 257309 CDS NP_938857.1 38233090 2649037 445872..446234 1 NC_002935.2 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 446234 rplV 2649037 rplV Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L22 NP_938857.1 445872 D 257309 CDS NP_938858.1 38233091 2648548 446234..446980 1 NC_002935.2 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 446980 rpsC 2648548 rpsC Corynebacterium diphtheriae NCTC 13129 30S ribosomal protein S3 NP_938858.1 446234 D 257309 CDS NP_938859.1 38233092 2648549 446984..447400 1 NC_002935.2 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 447400 rplP 2648549 rplP Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L16 NP_938859.1 446984 D 257309 CDS NP_938860.1 38233093 2648550 447400..447630 1 NC_002935.2 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 447630 rpmC 2648550 rpmC Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L29 NP_938860.1 447400 D 257309 CDS NP_938861.1 38233094 2648551 447633..447911 1 NC_002935.2 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 447911 rpsQ 2648551 rpsQ Corynebacterium diphtheriae NCTC 13129 30S ribosomal protein S17 NP_938861.1 447633 D 257309 CDS NP_938862.1 38233095 2648552 448082..449719 1 NC_002935.2 C-terminal region presents los similarity to Streptococcus pneumoniae hypothetical protein SP0785 TR:AAK74922 (EMBL:AE007385) (399 aa) fasta scores: E(): 4e-08, 28.25% id in 315 aa; hypothetical protein 449719 2648552 DIP0483 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938862.1 448082 D 257309 CDS NP_938863.1 38233096 2648553 449736..450452 1 NC_002935.2 Similar to Bacillus subtilis YknY protein TR:O31711 (EMBL:Z99111) (230 aa) fasta scores: E(): 3.2e-43, 57.01% id in 221 aa; ABC transporter ATP-binding protein 450452 2648553 DIP0484 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_938863.1 449736 D 257309 CDS NP_938864.1 38233097 2648554 450449..451759 1 NC_002935.2 Similar to Bacillus halodurans BH3121 protein TR:Q9K885 (EMBL:AP001517) (398 aa) fasta scores: E(): 4e-20, 33.33% id in 438 aa; ABC transporter inner membrane protein 451759 2648554 DIP0485 Corynebacterium diphtheriae NCTC 13129 ABC transporter inner membrane protein NP_938864.1 450449 D 257309 CDS NP_938865.1 38233098 2649533 451955..452323 1 NC_002935.2 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 452323 rplN 2649533 rplN Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L14 NP_938865.1 451955 D 257309 CDS NP_938866.1 38233099 2649534 452326..452640 1 NC_002935.2 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 452640 rplX 2649534 rplX Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L24 NP_938866.1 452326 D 257309 CDS NP_938867.1 38233100 2649535 452643..453206 1 NC_002935.2 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 453206 rplE 2649535 rplE Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L5 NP_938867.1 452643 D 257309 CDS NP_938868.1 38233101 2649536 453909..455252 1 NC_002935.2 Similar to Escherichia coli serine transporter SdaC or DcrA or B2796 or Z4113 or ECS3656 SW:SDAC_ECOLI (P36559) (429 aa) fasta scores: E(): 4.6e-100, 61.66% id in 420 aa; serine transporter 455252 sdaC 2649536 sdaC Corynebacterium diphtheriae NCTC 13129 serine transporter NP_938868.1 453909 D 257309 CDS NP_938869.1 38233102 2649537 455277..456653 1 NC_002935.2 Similar to Escherichia coli L-serine dehydratase 1 SdaA or B1814 SW:SDHL_ECOLI (P16095) (454 aa) fasta scores: E(): 4.8e-113, 63.08% id in 447 aa; L-serine dehydratase 1 456653 sdaA 2649537 sdaA Corynebacterium diphtheriae NCTC 13129 L-serine dehydratase 1 NP_938869.1 455277 D 257309 CDS NP_938870.1 38233103 2649538 456732..457760 1 NC_002935.2 Similar to Mycobacterium leprae probable L-asparaginase AnsA or ML1198 or MLCB458.13c SW:ASPG_MYCLE (Q9X7E6) (310 aa) fasta scores: E(): 6.4e-18, 36.39% id in 305 aa, and to Erwinia chrysanthemi L-asparaginase precursor AnsB or Asn SW:ASPG_ERWCH (P06608) (348 aa) fasta scores: E(): 2.5e-11, 30.9% id in 330 aa. Also similar to DIP1587, 306 aa; fasta scores: E(): 1.1e-48, 52.303% identity in 304 aa overlap. Note: Contains a twin-arginine translocation (TAT) system recognition motif (RRSFLG) at the N-terminal region; secreted amino acid hydrolase 457760 2649538 DIP0491 Corynebacterium diphtheriae NCTC 13129 secreted amino acid hydrolase NP_938870.1 456732 D 257309 CDS NP_938871.1 38233104 2650523 complement(457757..458800) 1 NC_002935.2 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB 458800 2650523 DIP0492 Corynebacterium diphtheriae NCTC 13129 molybdopterin biosynthesis protein MoeB NP_938871.1 457757 R 257309 CDS NP_938872.1 38233105 2650524 complement(458800..459795) 1 NC_002935.2 N-terminal region similar to the C-terminal region of Synechococcus sp molybdenum cofactor biosynthesis protein CB MoaCB SW:MOCB_SYNP7 (Q56208) (319 aa) fasta scores: E(): 5.2e-09, 35.06% id in 154 aa and C-terminal region similar to Mycobacterium tuberculosis molybdopterin converting factor subunit 2 MoAE or Rv3119 or MT3201 or MTCY164.29 SWALL:MOAE_MYCTU (SWALL:O05795) (147 aa) fasta scores: E(): 5.7e-11, 38.97% id in 136 aa; bifunctional molybdopterim biosynthesis protein 459795 2650524 DIP0493 Corynebacterium diphtheriae NCTC 13129 bifunctional molybdopterim biosynthesis protein NP_938872.1 458800 R 257309 CDS NP_938873.1 38233106 2650525 complement(460091..460834) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 hypothetical 24.2 kDa protein MT2696 TR:AAK47012 (EMBL:AE007102) (224 aa) fasta scores: E(): 1.3e-10, 31.37% id in 204 aa; hypothetical protein 460834 2650525 DIP0494 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938873.1 460091 R 257309 CDS NP_938874.1 38233107 2650526 complement(460848..462713) 1 NC_002935.2 N-terminal region similar to Mycobacterium tuberculosis molybdenum transport system permease ModB or Rv1858 or MT1906 or MTCY359.15c SW:MODB_MYCTU (P95156) blast scores: E(): 2e-32, score: 353 37% id, and C-terminal region to Mycobacterium tuberculosis molybdenum transport ATP-binding protein ModC or Rv1859 or MT1907 or MTCY359.14 SW:MODC_MYCTU (P95155) blast scores: E(): 1e-17, score: 93 28% id; molybdenum ABC transporter ATP-binding protein 462713 2650526 DIP0495 Corynebacterium diphtheriae NCTC 13129 molybdenum ABC transporter ATP-binding protein NP_938874.1 460848 R 257309 CDS NP_938875.1 38233108 2649063 complement(462759..463301) 1 NC_002935.2 Similar to part of Escherichia coli molybdate-binding periplasmic protein precursor ModA or B0763 SW:MODA_ECOLI (P37329) (257 aa) fasta scores: E(): 0.36, 31.6% id in 193 aa; molybdate binding protein (partial) 463301 2649063 DIP0496 Corynebacterium diphtheriae NCTC 13129 molybdate binding protein (partial) NP_938875.1 462759 R 257309 CDS NP_938876.1 38233109 2649064 complement(463533..464312) 1 NC_002935.2 Similar to Streptomyces coelicolor nitrate reductase gamma chain NarI TR:O86714 (EMBL:AL031515) (240 aa) fasta scores: E(): 1e-44, 49.78% id in 237 aa, and to Bacillus subtilis nitrate reductase gamma chain NarI SW:NARI_BACSU (P42177) (223 aa) fasta scores: E(): 6.2e-33, 42.27% id in 220 aa; nitrate reductase subunit gamma 464312 narI 2649064 narI Corynebacterium diphtheriae NCTC 13129 nitrate reductase subunit gamma NP_938876.1 463533 R 257309 CDS NP_938877.1 38233110 2649065 complement(464326..464955) 1 NC_002935.2 Similar to Streptomyces coelicolor nitrate reductase delta chain NarJ3 TR:Q9EWF5 (EMBL:AL451182) (220 aa) fasta scores: E(): 3e-20, 39.39% id in 198 aa, and to Bacillus subtilis nitrate reductase delta chain NarJ SW:NARJ_BACSU (P42178) (184 aa) fasta scores: E(): 1.9e-12, 29.14% id in 175 aa; nitrate reductase subunit delta 464955 2649065 DIP0498 Corynebacterium diphtheriae NCTC 13129 nitrate reductase subunit delta NP_938877.1 464326 R 257309 CDS NP_938878.1 38233111 2649066 complement(465007..466608) 1 NC_002935.2 Similar to Bacillus subtilis nitrate reductase beta chain NarH SW:NARH_BACSU (P42176) (487 aa) fasta scores: E(): 1.4e-114, 56.31% id in 499 aa; nitrate reductase subunit beta 466608 narH 2649066 narH Corynebacterium diphtheriae NCTC 13129 nitrate reductase subunit beta NP_938878.1 465007 R 257309 CDS NP_938879.1 38233112 2649067 complement(466608..470330) 1 NC_002935.2 Similar to Escherichia coli respiratory nitrate reductase 1 alpha chain NarG or NarC or BisD or B1224 SW:NARG_ECOLI (P09152) (1246 aa) fasta scores: E(): 0, 46.16% id in 1237 aa; respiratory nitrate reductase 1 subunit alpha 470330 narG 2649067 narG Corynebacterium diphtheriae NCTC 13129 respiratory nitrate reductase 1 subunit alpha NP_938879.1 466608 R 257309 CDS NP_938880.1 38233113 2649068 complement(470374..471705) 1 NC_002935.2 Similar to Thermus thermophilus Nark2 TR:Q9RA45 (EMBL:AJ237974) (443 aa) fasta scores: E(): 2e-79, 50.22% id in 448 aa, and to Escherichia coli nitrite extrusion protein 2 NarU or B1469 SW:NARU_ECOLI (P37758) (462 aa) fasta scores: E(): 1.2e-31, 33.47% id in 472 aa; nitrate/nitrite transport system integral membrane protein 471705 2649068 DIP0501 Corynebacterium diphtheriae NCTC 13129 nitrate/nitrite transport system integral membrane protein NP_938880.1 470374 R 257309 CDS NP_938881.1 38233114 2649069 complement(472039..473337) 1 NC_002935.2 Similar to Thermus thermophilus NarK1 TR:Q9RA46 (EMBL:AJ237974) (435 aa) fasta scores: E(): 2e-64, 59.56% id in 418 aa, and to Escherichia coli nitrite extrusion protein 1 NarK or B1223 SW:NARK_ECOLI (P10903) (463 aa) fasta scores: E(): 5.2e-17, 27.63% id in 427 aa; nitrate/nitrite transport system integral membrane protein 473337 narK 2649069 narK Corynebacterium diphtheriae NCTC 13129 nitrate/nitrite transport system integral membrane protein NP_938881.1 472039 R 257309 CDS NP_938882.1 38233115 2649102 473591..474085 1 NC_002935.2 Similar to Streptomyces coelicolor molybdenum cofactor biosynthesis protein MoaB TR:Q9RKA9 (EMBL:AL132674) (179 aa) fasta scores: E(): 7.6e-12, 35.13% id in 148 aa; molybdenum cofactor biosynthesis protein 474085 2649102 DIP0503 Corynebacterium diphtheriae NCTC 13129 molybdenum cofactor biosynthesis protein NP_938882.1 473591 D 257309 CDS NP_938883.1 38233116 2649103 complement(474082..474696) 1 NC_002935.2 Similar to Rhodobacter capsulatus molybdopterin-guanine dinucleotide biosynthesis protein A MobA SW:MOBA_RHOCA (Q9X7K0) (190 aa) fasta scores: E(): 6.3e-05, 29.53% id in 193 aa, and to Pseudomonas putida molybdopterin-guanine dinucleotide biosynthesis protein A MobA SW:MOBA_PSEPU (Q9WWW0) (191 aa) fasta scores: E(): 0.00032, 28.71% id in 195 aa; molybdopterin biosynthesis protein 474696 2649103 DIP0504 Corynebacterium diphtheriae NCTC 13129 molybdopterin biosynthesis protein NP_938883.1 474082 R 257309 CDS NP_938884.1 38233117 2649104 complement(474674..475141) 1 NC_002935.2 Similar to Streptomyces coelicolor molybdenum cofactor biosynthesis protein MoaC TR:Q9RKA8 (EMBL:AL132674) (170 aa) fasta scores: E(): 2.5e-29, 55.92% id in 152 aa, and to Escherichia coli, and molybdenum cofactor biosynthesis protein C MoaC or ChlA3 or B0783 or Z1002 or ECS0861 SW:MOAC_ECOLI (P30747) (160 aa) fasta scores: E(): 1.9e-19, 47.74% id in 155 aa; molybdenum cofactor biosynthesis protein 475141 moaC 2649104 moaC Corynebacterium diphtheriae NCTC 13129 molybdenum cofactor biosynthesis protein NP_938884.1 474674 R 257309 CDS NP_938885.1 38233118 2649105 complement(475157..476383) 1 NC_002935.2 Similar to Escherichia coli molybdopterin biosynthesis protein MoeA or ChlE or BisB or NarE or B0827 SW:MOEA_ECOLI (P12281) (411 aa) fasta scores: E(): 3.9e-25, 32.82% id in 326 aa; molybdopterin biosynthesis protein 476383 2649105 DIP0506 Corynebacterium diphtheriae NCTC 13129 molybdopterin biosynthesis protein NP_938885.1 475157 R 257309 CDS NP_938886.1 38233119 2649106 complement(476407..477438) 1 NC_002935.2 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 477438 moaA 2649106 moaA Corynebacterium diphtheriae NCTC 13129 molybdenum cofactor biosynthesis protein A NP_938886.1 476407 R 257309 CDS NP_938887.1 38233120 2649108 complement(479270..480190) 1 NC_002935.2 Similar to Agrobacterium tumefaciens Agr_C_1883p TR:AAK86832 (EMBL:AE008033) (294 aa) fasta scores: E(): 3.5e-20, 31.69% id in 306 aa, and to Bacillus subtilis dihydrodipicolinate synthase DapA SW:DAPA_BACSU (Q04796) (290 aa) fasta scores: E(): 1.1e-15, 29.68% id in 283 aa; lysine biosynthesis protein 480190 2649108 DIP0511 Corynebacterium diphtheriae NCTC 13129 lysine biosynthesis protein NP_938887.1 479270 R 257309 CDS NP_938888.1 38233121 2649109 complement(480224..481057) 1 NC_002935.2 Similar to Bacillus subtilis oligopeptide transport ATP-binding protein OppF or Spo0KE SW:OPPF_BACSU (P24137) (308 aa) fasta scores: E(): 1.7e-36, 48.51% id in 235 aa; oligopeptide ABC transporter ATP-binding protein 481057 2649109 DIP0512 Corynebacterium diphtheriae NCTC 13129 oligopeptide ABC transporter ATP-binding protein NP_938888.1 480224 R 257309 CDS NP_938889.1 38233122 2648729 complement(481063..483051) 1 NC_002935.2 C-terminal region similar to Salmonella typhimurium oligopeptide transport ATP-binding protein OppD or STM1743 SW:OPPD_SALTY (P04285) (335 aa) fasta scores: E(): 3.2e-38, 42.07% id in 328 aa, and N-terminal region to Bacillus firmus dipeptide transport system permease DppC SW:DPPC_BACFI (P94312) (304 aa) fasta scores: E(): 4.2e-32, 41.19% id in 267 aa; oligopeptide transport system (integral membrane and ATP-binding proteins) 483051 2648729 DIP0513 Corynebacterium diphtheriae NCTC 13129 oligopeptide transport system (integral membrane and ATP-binding proteins) NP_938889.1 481063 R 257309 CDS NP_938890.1 38233123 2648730 complement(483051..484016) 1 NC_002935.2 Similar to Bacillus subtilis oligopeptide transport system permease AppB SW:APPB_BACSU (P42062) (317 aa) fasta scores: E(): 4.6e-31, 34.7% id in 317 aa; oligopeptide transport system integral membrane protein 484016 2648730 DIP0514 Corynebacterium diphtheriae NCTC 13129 oligopeptide transport system integral membrane protein NP_938890.1 483051 R 257309 CDS NP_938891.1 38233124 2648731 complement(484258..485874) 1 NC_002935.2 Similar to Escherichia coli O157:H7 EDL933 transport protein Z1054 TR:AAG55204 (EMBL:AE005264) (512 aa) fasta scores: E(): 4.3e-19, 24% id in 479 aa. Note: Contains a twin-arginine translocation (TAT) system recognition motif (RRDFFK) at the N-terminal region; transport system secreted protein 485874 2648731 DIP0515 Corynebacterium diphtheriae NCTC 13129 transport system secreted protein NP_938891.1 484258 R 257309 CDS NP_938892.1 38233125 2648732 485970..486158 1 NC_002935.2 Doubtful CDS. No significant database matches; hypothetical protein 486158 2648732 DIP0516 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938892.1 485970 D 257309 CDS NP_938893.1 38233126 2648733 486216..486977 1 NC_002935.2 Similar to Escherichia coli galactonate operon transcriptional repressor DgoR or B3694/B3695 SW:DGOR_ECOLI (P31460) (229 aa) fasta scores: E(): 8.4e-09, 23.11% id in 199 aa; GntR family transcriptional regulator 486977 2648733 DIP0517 Corynebacterium diphtheriae NCTC 13129 GntR family transcriptional regulator NP_938893.1 486216 D 257309 CDS NP_938894.1 38233127 2648734 486974..487858 1 NC_002935.2 Similar to Streptomyces coelicolor glucokinase Glk or SC6E10.20c SW:GLK_STRCO (P40184) (317 aa) fasta scores: E(): 8e-13, 30.91% id in 317 aa; regulatory protein sugar kinase 487858 2648734 DIP0518 Corynebacterium diphtheriae NCTC 13129 regulatory protein sugar kinase NP_938894.1 486974 D 257309 CDS NP_938895.1 38233128 2648735 487887..488582 1 NC_002935.2 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 488582 2648735 DIP0519 Corynebacterium diphtheriae NCTC 13129 N-acetylmannosamine-6-phosphate 2-epimerase NP_938895.1 487887 D 257309 CDS NP_938896.1 38233129 2648736 488618..489754 1 NC_002935.2 Similar to Bacillus subtilis N-acetylglucosamine-6-phosphate deacetylase NagA SW:NAGA_BACSU (O34450) (396 aa) fasta scores: E(): 1.3e-23, 34.7% id in 389 aa, and to Escherichia coli, and N-acetylglucosamine-6-phosphate deacetylase NagA or B0677 or Z0824 or ECS0707 SW:NAGA_ECOLI (P15300) (382 aa) fasta scores: E(): 2.9e-18, 26.15% id in 390 aa; deacetylase 489754 2648736 DIP0520 Corynebacterium diphtheriae NCTC 13129 deacetylase NP_938896.1 488618 D 257309 CDS NP_938897.1 38233130 2648737 489788..490567 1 NC_002935.2 Similar to Streptomyces coelicolor glucosamine phosphate isomerase SC7E4.33c TR:Q9K487 (EMBL:AL359214) (261 aa) fasta scores: E(): 5e-50, 54.44% id in 259 aa, and to Escherichia coli glucosamine-6-phosphate isomerase NagB or GlmD or B0678 or Z0825 or ECS0708 SW:NAGB_ECOLI (P09375) (266 aa) fasta scores: E(): 4.4e-32, 44.39% id in 223 aa; isomerase 490567 2648737 DIP0521 Corynebacterium diphtheriae NCTC 13129 isomerase NP_938897.1 489788 D 257309 CDS NP_938898.1 38233131 2648738 complement(490628..492664) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 48.2 kDa protein SCC75A.17c TR:Q9RKQ7 (EMBL:AL133220) (477 aa) fasta scores: E(): 4.8e-06, 25.21% id in 353 aa; hypothetical protein 492664 2648738 DIP0522 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938898.1 490628 R 257309 CDS NP_938899.1 38233132 2648739 complement(492762..493763) 1 NC_002935.2 hypothetical protein 493763 2648739 DIP0523 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938899.1 492762 R 257309 CDS NP_938900.1 38233133 2649679 494228..494626 1 NC_002935.2 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 494626 rpsH 2649679 rpsH Corynebacterium diphtheriae NCTC 13129 30S ribosomal protein S8 NP_938900.1 494228 D 257309 CDS NP_938901.1 38233134 2649680 494642..495178 1 NC_002935.2 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 495178 rplF 2649680 rplF Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L6 NP_938901.1 494642 D 257309 CDS NP_938902.1 38233135 2649681 495220..495588 1 NC_002935.2 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 495588 rplR 2649681 rplR Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L18 NP_938902.1 495220 D 257309 CDS NP_938903.1 38233136 2649682 495629..496255 1 NC_002935.2 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 496255 rpsE 2649682 rpsE Corynebacterium diphtheriae NCTC 13129 30S ribosomal protein S5 NP_938903.1 495629 D 257309 CDS NP_938904.1 38233137 2649683 496259..496444 1 NC_002935.2 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 496444 rpmD 2649683 rpmD Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L30 NP_938904.1 496259 D 257309 CDS NP_938905.1 38233138 2649684 496447..496893 1 NC_002935.2 late assembly protein; 50S ribosomal protein L15 496893 rplO 2649684 rplO Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L15 NP_938905.1 496447 D 257309 CDS NP_938906.1 38233139 2649685 497070..497870 1 NC_002935.2 Similar to Streptococcus pneumoniae transporter, FNT family, SP1215 TR:AAK75321 (EMBL:AE007421) (265 aa) fasta scores: E(): 1.4e-31, 42.24% id in 258 aa; transporter 497870 2649685 DIP0530 Corynebacterium diphtheriae NCTC 13129 transporter NP_938906.1 497070 D 257309 CDS NP_938907.1 38233140 2649686 complement(497871..498605) 1 NC_002935.2 Similar to Mycobacterium tuberculosis FdhD protein homolog or Rv2899c or MT2967 or MTCY274.30c SW:FDHD_MYCTU (Q10820) (276 aa) fasta scores: E(): 0.0013, 28.34% id in 254 aa; hypothetical protein 498605 2649686 DIP0531 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938907.1 497871 R 257309 CDS NP_938908.1 38233141 2649687 complement(498593..500293) 1 NC_002935.2 Similar to Streptomyces coelicolor alpha-glucosidase AglA TR:Q9KZ09 (EMBL:AL355752) (577 aa) fasta scores: E(): 2.2e-97, 48.09% id in 578 aa; amylase 500293 2649687 DIP0532 Corynebacterium diphtheriae NCTC 13129 amylase NP_938908.1 498593 R 257309 CDS NP_938909.1 38233142 2650533 complement(500305..502095) 1 NC_002935.2 Similar to Bacillus coagulans oligo-1,6-glucosidase MalL SW:O16G_BACCO (Q45101) (555 aa) fasta scores: E(): 1.3e-26, 30.98% id in 539 aa; glycosylase 502095 2650533 DIP0533 Corynebacterium diphtheriae NCTC 13129 glycosylase NP_938909.1 500305 R 257309 CDS NP_938910.1 38233143 2650271 502322..503563 1 NC_002935.2 Similar to Lactococcus lactis maltose ABC transporter substrate binding protein MalE TR:Q9CEZ8 (EMBL:AE006399) (410 aa) fasta scores: E(): 8.8e-35, 33.66% id in 407 aa; sugar-binding secreted protein 503563 2650271 DIP0534 Corynebacterium diphtheriae NCTC 13129 sugar-binding secreted protein NP_938910.1 502322 D 257309 CDS NP_938911.1 38233144 2648818 503681..505084 1 NC_002935.2 Similar to Lactococcus lactis maltose ABC transporter permease MalF TR:Q9CEZ7 (EMBL:AE006399) (452 aa) fasta scores: E(): 9.4e-61, 39.15% id in 452 aa; sugar ABC transport system membrane protein 505084 2648818 DIP0535 Corynebacterium diphtheriae NCTC 13129 sugar ABC transport system membrane protein NP_938911.1 503681 D 257309 CDS NP_938912.1 38233145 2648819 505084..505962 1 NC_002935.2 Similar to Streptococcus pneumoniae maltodextrin transport system permease MalD or SP2110 SW:MALD_STRPN (Q04699) (277 aa) fasta scores: E(): 2.9e-21, 30.85% id in 282 aa; sugar ABC transport system membrane protein 505962 2648819 DIP0536 Corynebacterium diphtheriae NCTC 13129 sugar ABC transport system membrane protein NP_938912.1 505084 D 257309 CDS NP_938913.1 38233146 2648820 506046..506768 1 NC_002935.2 ABC transporter 506768 2648820 DIP0537 Corynebacterium diphtheriae NCTC 13129 ABC transporter NP_938913.1 506046 D 257309 CDS NP_938914.1 38233147 2648821 complement(506765..508018) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 46.2 kDa protein SC5F8.10c TR:Q9K4L4 (EMBL:AL357613) (410 aa) fasta scores: E(): 2.1e-74, 50% id in 394 aa; hypothetical protein 508018 2648821 DIP0538 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938914.1 506765 R 257309 CDS NP_938915.1 38233148 2648822 complement(508133..509269) 1 NC_002935.2 Similar to Bacillus subtilis probable multiple sugar-binding transport ATP-binding protein MsmX SW:MSMX_BACSU (P94360) (365 aa) fasta scores: E(): 1.1e-54, 49.86% id in 367 aa; sugar ABC transport syste ATP-binding protein 509269 2648822 DIP0539 Corynebacterium diphtheriae NCTC 13129 sugar ABC transport syste ATP-binding protein NP_938915.1 508133 R 257309 CDS NP_938916.1 38233149 2648823 509759..511081 1 NC_002935.2 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 511081 secY 2648823 secY Corynebacterium diphtheriae NCTC 13129 preprotein translocase subunit SecY NP_938916.1 509759 D 257309 CDS NP_938917.1 38233150 2650860 511081..511626 1 NC_002935.2 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 511626 adk 2650860 adk Corynebacterium diphtheriae NCTC 13129 adenylate kinase NP_938917.1 511081 D 257309 CDS NP_938918.1 38233151 2650861 511740..512534 1 NC_002935.2 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 512534 mapA 2650861 mapA Corynebacterium diphtheriae NCTC 13129 methionine aminopeptidase NP_938918.1 511740 D 257309 CDS NP_938919.1 38233152 2650862 512872..515037 1 NC_002935.2 Similar to Micromonospora viridifaciens sialidase precursor NedA SW:NANH_MICVI (Q02834) (647 aa) fasta scores: E(): 4e-06, 33.62% id in 455 aa. Note: Contains a potential colied-coil region at residues 518..639; sialidase 515037 2650862 DIP0543 Corynebacterium diphtheriae NCTC 13129 sialidase NP_938919.1 512872 D 257309 CDS NP_938920.1 38233153 2648832 515101..515910 1 NC_002935.2 Similar to Streptomyces coelicolor secreted protein 3SC5B7.14c TR:Q9EWT5 (EMBL:AL449216) (231 aa) fasta scores: E(): 9.9e-08, 30.99% id in 242 aa; hypothetical protein 515910 2648832 DIP0544 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938920.1 515101 D 257309 CDS NP_938921.1 38233154 2648833 516214..516432 1 NC_002935.2 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 516432 infA 2648833 infA Corynebacterium diphtheriae NCTC 13129 translation initiation factor IF-1 NP_938921.1 516214 D 257309 CDS NP_938922.1 38233155 2648834 516618..516986 1 NC_002935.2 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 516986 rpsM 2648834 rpsM Corynebacterium diphtheriae NCTC 13129 30S ribosomal protein S13 NP_938922.1 516618 D 257309 CDS NP_938923.1 38233156 2648835 516990..517394 1 NC_002935.2 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 517394 rpsK 2648835 rpsK Corynebacterium diphtheriae NCTC 13129 30S ribosomal protein S11 NP_938923.1 516990 D 257309 CDS NP_938924.1 38233157 2648836 517418..518023 1 NC_002935.2 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 518023 rpsD 2648836 rpsD Corynebacterium diphtheriae NCTC 13129 30S ribosomal protein S4 NP_938924.1 517418 D 257309 CDS NP_938925.1 38233158 2648837 518105..519121 1 NC_002935.2 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 519121 rpoA 2648837 rpoA Corynebacterium diphtheriae NCTC 13129 DNA-directed RNA polymerase subunit alpha NP_938925.1 518105 D 257309 CDS NP_938926.1 38233159 2648838 519202..519675 1 NC_002935.2 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 519675 rplQ 2648838 rplQ Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L17 NP_938926.1 519202 D 257309 CDS NP_938927.1 38233160 2648839 519770..520657 1 NC_002935.2 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 520657 truA 2648839 truA Corynebacterium diphtheriae NCTC 13129 tRNA pseudouridine synthase A NP_938927.1 519770 D 257309 CDS NP_938928.1 38233161 2648840 520801..522099 1 NC_002935.2 Low similarity to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3556 TR:AAK47896 (EMBL:AE007159) (482 aa) fasta scores: E(): 8.1e-16, 29.36% id in 487 aa; hypothetical protein 522099 2648840 DIP0552 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938928.1 520801 D 257309 CDS NP_938929.1 38233162 2648841 522208..522630 1 NC_002935.2 Low similarity to Streptomyces coelicolor membrane protein SCl2.30c TR:Q9L269 (EMBL:AL137778) (150 aa) fasta scores: E(): 1.9e-06, 35.48% id in 93 aa; hypothetical protein 522630 2648841 DIP0553 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938929.1 522208 D 257309 CDS NP_938930.1 38233163 2648842 complement(522858..523757) 1 NC_002935.2 Similar to Streptomyces coelicolor serine protease SC3C3.08 TR:O86642 (EMBL:AL031231) (413 aa) fasta scores: E(): 4e-11, 32.37% id in 278 aa and to Mycobacterium tuberculosis hypothetical 46.0 kDa protein Rv3449 or MTCY13E12.02 or MT3555 SWALL:O06316 (EMBL:Z95390) (455 aa) fasta scores: E(): 4.7e-10, 38.11% id in 307 aa; subtilisin-like cell wall associated serine protease (mycosin) 523757 2648842 DIP0554 Corynebacterium diphtheriae NCTC 13129 subtilisin-like cell wall associated serine protease (mycosin) NP_938930.1 522858 R 257309 CDS NP_938931.1 38233164 2648875 complement(523770..525185) 1 NC_002935.2 Very low similarity to Mycobacterium tuberculosis hypothetical protein Rv3448 or MTCY77.20 or MT3554 SWALL:O33354 (EMBL:Z95390) (467 aa) fasta scores: E(): 0.0016, 21.96% id in 478 aa. Note: Contains a sortase anchor site (LPNTG); surface-anchored membrane protein 525185 2648875 DIP0555 Corynebacterium diphtheriae NCTC 13129 surface-anchored membrane protein NP_938931.1 523770 R 257309 CDS NP_938932.1 38233165 2648876 525441..528980 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 FtsK/SpoIIIE family protein MT3553 TR:AAK47893 (EMBL:AE007159) (1200 aa) fasta scores: E(): 1.7e-97, 37.59% id in 1221 aa; FtsK/SpoIIIE family ATP-binding protein 528980 2648876 DIP0556 Corynebacterium diphtheriae NCTC 13129 FtsK/SpoIIIE family ATP-binding protein NP_938932.1 525441 D 257309 CDS NP_938933.1 38233166 2648877 529045..530034 1 NC_002935.2 hypothetical protein 530034 2648877 DIP0557 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938933.1 529045 D 257309 CDS NP_938934.1 38233167 2648878 530237..530554 1 NC_002935.2 Very low similarity to Mycobacterium tuberculosis hypothetical 13.5 kDa protein Rv3445c or MTCY77.17c TR:O06262 (EMBL:Z95389) (125 aa) fasta scores: E(): 0.0007, 31.52% id in 92 aa; CFP-10-like protein 530554 2648878 DIP0558 Corynebacterium diphtheriae NCTC 13129 CFP-10-like protein NP_938934.1 530237 D 257309 CDS NP_938935.1 38233168 2648879 530599..530886 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 11.1 kDa protein Rv3444c or MTCY77.16c TR:O06261 (EMBL:Z95389) (100 aa) fasta scores: E(): 1e-08, 35.48% id in 93 aa; ESAT-6-like protein 530886 2648879 DIP0559 Corynebacterium diphtheriae NCTC 13129 ESAT-6-like protein NP_938935.1 530599 D 257309 CDS NP_938936.1 38233169 2648880 530900..531049 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 531049 2648880 DIP0560 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938936.1 530900 D 257309 CDS NP_938937.1 38233170 2648881 531311..531754 1 NC_002935.2 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 531754 rplM 2648881 rplM Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L13 NP_938937.1 531311 D 257309 CDS NP_938938.1 38233171 2648882 531751..532284 1 NC_002935.2 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 532284 rpsI 2648882 rpsI Corynebacterium diphtheriae NCTC 13129 30S ribosomal protein S9 NP_938938.1 531751 D 257309 CDS NP_938939.1 38233172 2649509 532453..533796 1 NC_002935.2 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 533796 glmM 2649509 glmM Corynebacterium diphtheriae NCTC 13129 phosphoglucosamine mutase NP_938939.1 532453 D 257309 CDS NP_938940.1 38233173 2649510 533901..534200 1 NC_002935.2 hypothetical protein 534200 2649510 DIP0564 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938940.1 533901 D 257309 CDS NP_938941.1 38233174 2649511 534197..535513 1 NC_002935.2 No significant database matches. High concentration of alanine, glycine and proline residues; hypothetical protein 535513 2649511 DIP0565 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938941.1 534197 D 257309 CDS NP_938942.1 38233175 2649512 535507..535767 1 NC_002935.2 hypothetical protein 535767 2649512 DIP0566 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938942.1 535507 D 257309 CDS NP_938943.1 38233176 2649513 complement(535786..536649) 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical protein ML0370 TR:Q9CCV6 (EMBL:AL583918) (289 aa) fasta scores: E(): 6.4e-34, 42.46% id in 252 aa; hypothetical protein 536649 2649513 DIP0567 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938943.1 535786 R 257309 CDS NP_938944.1 38233177 2649514 536812..537960 1 NC_002935.2 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 537960 alr 2649514 alr Corynebacterium diphtheriae NCTC 13129 alanine racemase NP_938944.1 536812 D 257309 CDS NP_938945.1 38233178 2648765 537967..538461 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 18.2 kDa protein Rv3422c or MT3531 or MTCY78.07 SW:YY22_MYCTU (Q50706) (168 aa) fasta scores: E(): 4.4e-19, 46.71% id in 152 aa; hypothetical protein 538461 2648765 DIP0569 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938945.1 537967 D 257309 CDS NP_938946.1 38233179 2648766 538648..540333 1 NC_002935.2 Similar to Escherichia coli O157:H7 transport protein ECS4625 TR:BAB38048 (EMBL:AP002566) (561 aa) fasta scores: E(): 3.1e-24, 29.47% id in 536 aa; hypothetical protein 540333 2648766 DIP0570 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938946.1 538648 D 257309 CDS NP_938947.1 38233180 2648767 540480..540953 1 NC_002935.2 hypothetical protein 540953 2648767 DIP0571 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938947.1 540480 D 257309 CDS NP_938948.1 38233181 2648768 541021..541689 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical 38.0 kDa protein ML0378 precursor or B229_C1_170 SW:YY21_MYCLE (Q49857) (359 aa) fasta scores: E(): 4.2e-30, 48.16% id in 218 aa; hypothetical protein 541689 2648768 DIP0572 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938948.1 541021 D 257309 CDS NP_938949.1 38233182 2648769 541690..542181 1 NC_002935.2 Similar to Escherichia coli ribosomal-protein-alanine acetyltransferase RimI or B4373 or Z5974 or ECS5331 SW:RIMI_ECOLI (P09453) (148 aa) fasta scores: E(): 4.9e-09, 34.4% id in 125 aa; ribosomal-protein-alanine acetyltransferase 542181 2648769 DIP0573 Corynebacterium diphtheriae NCTC 13129 ribosomal-protein-alanine acetyltransferase NP_938949.1 541690 D 257309 CDS NP_938950.1 38233183 2648770 542182..543234 1 NC_002935.2 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 543234 2648770 DIP0574 Corynebacterium diphtheriae NCTC 13129 DNA-binding/iron metalloprotein/AP endonuclease NP_938950.1 542182 D 257309 CDS NP_938951.1 38233184 2648771 543376..543672 1 NC_002935.2 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 543672 groES 2648771 groES Corynebacterium diphtheriae NCTC 13129 co-chaperonin GroES NP_938951.1 543376 D 257309 CDS NP_938952.1 38233185 2648772 543685..545304 1 NC_002935.2 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth; molecular chaperone GroEL 545304 groEL 2648772 groEL Corynebacterium diphtheriae NCTC 13129 molecular chaperone GroEL NP_938952.1 543685 D 257309 CDS NP_938953.1 38233186 2649651 545504..546070 1 NC_002935.2 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this protein is involved in expression of ribosome-associated gene products in stationary phase; RNA polymerase sigma factor SigD 546070 2649651 DIP0577 Corynebacterium diphtheriae NCTC 13129 RNA polymerase sigma factor SigD NP_938953.1 545504 D 257309 CDS NP_938954.1 38233187 2649652 546067..546969 1 NC_002935.2 hypothetical protein 546969 2649652 DIP0578 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938954.1 546067 D 257309 CDS NP_938955.1 38233188 2649653 complement(547039..547425) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 15.3 kDa protein Rv3412 or MT3521 or MTCY78.16C SW:YY12_MYCTU (Q50714) (136 aa) fasta scores: E(): 7.8e-18, 43.36% id in 113 aa; hypothetical protein 547425 2649653 DIP0579 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938955.1 547039 R 257309 CDS NP_938956.1 38233189 2649654 547582..549102 1 NC_002935.2 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 549102 guaB 2649654 guaB Corynebacterium diphtheriae NCTC 13129 inosine 5'-monophosphate dehydrogenase NP_938956.1 547582 D 257309 CDS NP_938957.1 38233190 2649655 549130..550275 1 NC_002935.2 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase 550275 2649655 DIP0581 Corynebacterium diphtheriae NCTC 13129 inosine 5-monophosphate dehydrogenase NP_938957.1 549130 D 257309 CDS NP_938958.1 38233191 2649656 550408..551304 1 NC_002935.2 Similar to Escherichia coli iron FecB or B4290 SW:FECB_ECOLI (P15028) (300 aa) fasta scores: E(): 1.6e-12, 28.57% id in 287 aa; iron transport system binding (secreted) protein 551304 2649656 DIP0582 Corynebacterium diphtheriae NCTC 13129 iron transport system binding (secreted) protein NP_938958.1 550408 D 257309 CDS NP_938959.1 38233192 2649657 551335..552324 1 NC_002935.2 Similar to Escherichia coli iron FecC or B4289 SW:FECC_ECOLI (P15030) (332 aa) fasta scores: E(): 1.6e-22, 33.77% id in 305 aa; iron transport system membrane protein 552324 2649657 DIP0583 Corynebacterium diphtheriae NCTC 13129 iron transport system membrane protein NP_938959.1 551335 D 257309 CDS NP_938960.1 38233193 2649658 552324..553307 1 NC_002935.2 Similar to Escherichia coli iron FecD or B4288 SW:FECD_ECOLI (P15029) (318 aa) fasta scores: E(): 2.6e-28, 35.01% id in 317 aa; iron transport system membrane protein 553307 2649658 DIP0584 Corynebacterium diphtheriae NCTC 13129 iron transport system membrane protein NP_938960.1 552324 D 257309 CDS NP_938961.1 38233194 2650252 553311..554123 1 NC_002935.2 Similar to Bacillus subtilis ferrichrome transport ATP-binding protein FhuC SW:FHUC_BACSU (P49938) (269 aa) fasta scores: E(): 1.2e-37, 45.13% id in 257 aa, and to Escherichia coli iron FecE or B4287 SW:FECE_ECOLI (P15031) (255 aa) fasta scores: E(): 5e-32, 42.8% id in 250 aa; iron ABC transporter ATP-binding protein 554123 2650252 DIP0585 Corynebacterium diphtheriae NCTC 13129 iron ABC transporter ATP-binding protein NP_938961.1 553311 D 257309 CDS NP_938962.1 38233195 2650253 554145..557468 1 NC_002935.2 Similar in its N-terminal region and C-terminal region to Rhizobium sp hypothetical 71.0 kDa protein Y4xN SW:Y4XN_RHISN (P55706) blast scores: E(): 3e-23, score: 277 22% id and also to Rhizobium meliloti rhizobactin siderophore biosynthesis protein RhbC or RhsC or RA1260 or SMA2404 SWALL:AAK65918 (EMBL:AF110737) (585 aa) fasta scores: E(): 6e-12, 26.23% id in 526 aa. Possible duplication; siderophore biosynthesis-like protein 557468 2650253 DIP0586 Corynebacterium diphtheriae NCTC 13129 siderophore biosynthesis-like protein NP_938962.1 554145 D 257309 CDS NP_938963.1 38233196 2650254 557508..558737 1 NC_002935.2 Similar to Streptomyces coelicolor membrane transport protein SC5F8.19 TR:Q9K4K5 (EMBL:AL357613) (444 aa) fasta scores: E(): 7.2e-10, 27.72% id in 404 aa; hypothetical protein 558737 2650254 DIP0587 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938963.1 557508 D 257309 CDS NP_938964.1 38233197 2650255 558764..559198 1 NC_002935.2 hypothetical protein 559198 2650255 DIP0588 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938964.1 558764 D 257309 CDS NP_938965.1 38233198 2650256 complement(559337..560233) 1 NC_002935.2 Similar to Streptomyces coelicolor integral membrane protein SCD10.06 TR:Q9K3X0 (EMBL:AL359988) (295 aa) fasta scores: E(): 6.6e-36, 43.82% id in 267 aa; hypothetical protein 560233 2650256 DIP0589 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938965.1 559337 R 257309 CDS NP_938966.1 38233199 2649110 560966..561250 1 NC_002935.2 hypothetical protein 561250 2649110 DIP0592 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938966.1 560966 D 257309 CDS NP_938967.1 38233200 2649111 561256..561825 1 NC_002935.2 hypothetical protein 561825 2649111 DIP0593 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938967.1 561256 D 257309 CDS NP_938968.1 38233201 2649112 562125..562346 1 NC_002935.2 hypothetical protein 562346 2649112 DIP0594 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938968.1 562125 D 257309 CDS NP_938969.1 38233202 2649349 562428..564005 1 NC_002935.2 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 564005 guaA 2649349 guaA Corynebacterium diphtheriae NCTC 13129 GMP synthase NP_938969.1 562428 D 257309 CDS NP_938970.1 38233203 2649113 complement(564081..564779) 1 NC_002935.2 hypothetical protein 564779 2649113 DIP0596 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938970.1 564081 R 257309 CDS NP_938971.1 38233204 2649114 564837..565313 1 NC_002935.2 hypothetical protein 565313 2649114 DIP0597 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938971.1 564837 D 257309 CDS NP_938972.1 38233205 2649115 complement(565332..566465) 1 NC_002935.2 hypothetical protein 566465 2649115 DIP0598 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938972.1 565332 R 257309 CDS NP_938973.1 38233206 2649116 566547..567758 1 NC_002935.2 Similar to Streptomyces coelicolor two-component system sensor kinase SCD63A.02 TR:Q9KY73 (EMBL:AL356832) (430 aa) fasta scores: E(): 3e-12, 37.09% id in 434 aa; two component system sensor kinase 567758 2649116 DIP0599 Corynebacterium diphtheriae NCTC 13129 two component system sensor kinase NP_938973.1 566547 D 257309 CDS NP_938974.1 38233207 2649117 567764..568459 1 NC_002935.2 Similar to Streptomyces coelicolor two-component system DNA-binding response regulator SSCD63A.03 TR:Q9KY72 (EMBL:AL356832) (251 aa) fasta scores: E(): 3.8e-26, 58.72% id in 235 aa, and to Bacillus brevis transcriptional regulatory protein DegU SW:DEGU_BACBR (P54662) (236 aa) fasta scores: E(): 2.7e-10, 30.97% id in 226 aa; two component system response regulator 568459 2649117 DIP0600 Corynebacterium diphtheriae NCTC 13129 two component system response regulator NP_938974.1 567764 D 257309 CDS NP_938975.1 38233208 2649118 568608..568958 1 NC_002935.2 hypothetical protein 568958 2649118 DIP0601 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938975.1 568608 D 257309 CDS NP_938976.1 38233209 2649119 complement(569168..569617) 1 NC_002935.2 hypothetical protein 569617 2649119 DIP0602 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938976.1 569168 R 257309 CDS NP_938977.1 38233210 2649120 569646..570416 1 NC_002935.2 hypothetical protein 570416 2649120 DIP0603 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938977.1 569646 D 257309 CDS NP_938978.1 38233211 2648522 570425..571951 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 56.7 kDa protein Rv3394c or MTV004.52c TR:O50419 (EMBL:AL009198) (527 aa) fasta scores: E(): 2e-34, 32.63% id in 527 aa; hypothetical protein 571951 2648522 DIP0604 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938978.1 570425 D 257309 CDS NP_938979.1 38233212 2648523 complement(571955..572656) 1 NC_002935.2 hypothetical protein 572656 2648523 DIP0605 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938979.1 571955 R 257309 CDS NP_938980.1 38233213 2648524 572761..573639 1 NC_002935.2 Similar to Corynebacterium glutamicum hypothetical 31.3 kDa protein TR:Q93QX1 (EMBL:AF159510) (287 aa) fasta scores: E(): 3.9e-56, 51.52% id in 295 aa; hypothetical protein 573639 2648524 DIP0606 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938980.1 572761 D 257309 CDS NP_938981.1 38233214 2648525 complement(573656..575113) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 33.4 kDa protein Rv3104c or MTCY164.14c TR:O05781 (EMBL:Z95150) (308 aa) fasta scores: E(): 1.3e-15, 33.94% id in 271 aa; hypothetical protein 575113 2648525 DIP0607 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938981.1 573656 R 257309 CDS NP_938982.1 38233215 2648526 complement(575214..575891) 1 NC_002935.2 Similar to Staphylococcus aureus (strain N315) SA0421 protein or SAV0463 TR:BAB56625 (EMBL:AP003130) (219 aa) fasta scores: E(): 1.7e-31, 46.6% id in 206 aa, and to Salmonella enteritidis integral membrane protein SfbC TR:Q9S4Y9 (EMBL:AF102556) (202 aa) fasta scores: E(): 8.9e-28, 42.71% id in 199 aa; ABC transporter 575891 2648526 DIP0608 Corynebacterium diphtheriae NCTC 13129 ABC transporter NP_938982.1 575214 R 257309 CDS NP_938983.1 38233216 2648527 complement(575888..576910) 1 NC_002935.2 Similar to Bacillus halodurans ABC transporter BH3481 TR:Q9K789 (EMBL:AP001518) (338 aa) fasta scores: E(): 1.1e-47, 48.61% id in 325 aa, and to N-terminal region of Escherichia coli ATP-binding protein ABC or B0199 SW:ABC_ECOLI (P30750) (343 aa) fasta scores: E(): 3.9e-43, 55.2% id in 250 aa; ABC transporter ATP-binding protein 576910 2648527 DIP0609 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_938983.1 575888 R 257309 CDS NP_938984.1 38233217 2648528 complement(576948..577820) 1 NC_002935.2 Similar to Escherichia coli lipoprotein-28 precursor NlpA or B3661 SW:NLPA_ECOLI (P04846) (272 aa) fasta scores: E(): 1.9e-20, 34.36% id in 259 aa. Possible duplication of the CDS upstream, CDIP0611 (66.667% identity in 288 aa overlap); ABC transporter 577820 2648528 DIP0610 Corynebacterium diphtheriae NCTC 13129 ABC transporter NP_938984.1 576948 R 257309 CDS NP_938985.1 38233218 2648529 complement(577994..578866) 1 NC_002935.2 Similar to Escherichia coli lipoprotein-28 precursor NlpA or B3661 SW:NLPA_ECOLI (P04846) (272 aa) fasta scores: E(): 1.5e-20, 33.83% id in 266 aa. Possible duplication of the CDS downstream, CDIP0610 (66.667% identity in 288 aa overlap); ABC transporter 578866 2648529 DIP0611 Corynebacterium diphtheriae NCTC 13129 ABC transporter NP_938985.1 577994 R 257309 CDS NP_938986.1 38233219 2648530 579083..582202 1 NC_002935.2 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase.; error-prone DNA polymerase 582202 dnaE2 2648530 dnaE2 Corynebacterium diphtheriae NCTC 13129 error-prone DNA polymerase NP_938986.1 579083 D 257309 CDS NP_938987.1 38233220 2648531 582222..582692 1 NC_002935.2 Similar to Streptomyces coelicolor integral membrane protein SCE126.11 TR:Q9X854 (EMBL:AL049630) (151 aa) fasta scores: E(): 1.4e-15, 41.21% id in 148 aa; hypothetical protein 582692 2648531 DIP0613 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938987.1 582222 D 257309 CDS NP_938988.1 38233221 2648532 582689..584029 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 47.7 kDa protein SCE9.01 TR:Q9X8H4 (EMBL:AL049841) (436 aa) fasta scores: E(): 8.3e-18, 28.97% id in 428 aa; hypothetical protein 584029 2648532 DIP0614 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938988.1 582689 D 257309 CDS NP_938989.1 38233222 2648533 584097..585062 1 NC_002935.2 Similar to Yersinia pestis periplasmic chelated iron-binding protein YfeA precursor or YPO2439 SW:YFEA_YERPE (Q56952) (311 aa) fasta scores: E(): 1.8e-19, 30.03% id in 303 aa; ABC transporter 585062 2648533 DIP0615 Corynebacterium diphtheriae NCTC 13129 ABC transporter NP_938989.1 584097 D 257309 CDS NP_938990.1 38233223 2650466 585131..585916 1 NC_002935.2 Similar to Yersinia pestis chelated iron transport system membrane protein YfeB or YPO2440 SW:YFEB_YERPE (Q56953) (296 aa) fasta scores: E(): 1.7e-20, 37.05% id in 251 aa; ABC transporter ATP-binding protein 585916 2650466 DIP0616 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_938990.1 585131 D 257309 CDS NP_938991.1 38233224 2650467 585906..586739 1 NC_002935.2 Similar to Yersinia pestis chelated iron transport system membrane protein YfeC or YPO2441 SW:YFEC_YERPE (Q56954) (294 aa) fasta scores: E(): 1.6e-13, 26.81% id in 276 aa; ABC transporter 586739 2650467 DIP0617 Corynebacterium diphtheriae NCTC 13129 ABC transporter NP_938991.1 585906 D 257309 CDS NP_938992.1 38233225 2650468 586736..587542 1 NC_002935.2 Similar to Lactococcus lactis manganese ABC transporter permease MtsC TR:Q9CFZ4 (EMBL:AE006363) (281 aa) fasta scores: E(): 3.3e-13, 27.96% id in 261 aa; ABC transporter 587542 2650468 DIP0618 Corynebacterium diphtheriae NCTC 13129 ABC transporter NP_938992.1 586736 D 257309 CDS NP_938993.1 38233226 2650469 587557..588171 1 NC_002935.2 Similar to Mycobacterium tuberculosis iron-dependent repressor IdeR or DtxR or Rv2711 or MT2784 or MTCY05A6.32 SW:IDER_MYCTU (Q50495) (230 aa) fasta scores: E(): 1.1e-10, 31.84% id in 201 aa and low similarity to Corynebacterium diphtheriae diphtheria toxin repressor DtxR SW:DTXR_CORDI (P33120) (226 aa) fasta scores: E(): 7.7e-08, 35.08% identity in 114 aa overlap; diphtheria toxin repressor 2 588171 2650469 DIP0619 Corynebacterium diphtheriae NCTC 13129 diphtheria toxin repressor 2 NP_938993.1 587557 D 257309 CDS NP_938994.1 38233227 2650470 588393..589238 1 NC_002935.2 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 589238 folD 2650470 folD Corynebacterium diphtheriae NCTC 13129 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase NP_938994.1 588393 D 257309 CDS NP_938995.1 38233228 2650471 589231..589557 1 NC_002935.2 hypothetical protein 589557 2650471 DIP0621 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938995.1 589231 D 257309 CDS NP_938996.1 38233229 2649046 complement(589692..590957) 1 NC_002935.2 hypothetical protein 590957 2649046 DIP0622 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938996.1 589692 R 257309 CDS NP_938997.1 38233230 2649047 complement(591014..592117) 1 NC_002935.2 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase 592117 metX 2649047 metX Corynebacterium diphtheriae NCTC 13129 homoserine O-acetyltransferase NP_938997.1 591014 R 257309 CDS NP_938998.1 38233231 2649048 complement(592180..592731) 1 NC_002935.2 hypothetical protein 592731 2649048 DIP0624 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938998.1 592180 R 257309 CDS NP_938999.1 38233232 2649049 592944..594719 1 NC_002935.2 Similar to the C-terminal region of Corynebacterium ulcerans HtaA TR:Q9EZ58 (EMBL:AF304009) (410 aa) fasta scores: E(): 4.9e-58, 54.14% id in 410 aa, and to Streptomyces coelicolor hypothetical 48.2 kDa protein SCC75A.17c TR:Q9RKQ7 (EMBL:AL133220) (477 aa) fasta scores: E(): 4.9e-06, 26.25% id in 579 aa; hypothetical protein 594719 2649049 DIP0625 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_938999.1 592944 D 257309 CDS NP_939000.1 38233233 2649050 594730..595791 1 NC_002935.2 Identical to previously sequenced Corynebacterium diphtheriae HmuT precursor TR:Q9XD89 (EMBL:AF109162) (353 aa) fasta scores: E(): 3.9e-123, 98.86% id in 353 aa, and highly similar to Corynebacterium ulcerans hemin receptor precursor HmuT TR:Q9EZ57 (EMBL:AF304009) (351 aa) fasta scores: E(): 2.6e-99, 79.83% id in 352 aa; Iron-related transport system receptor protein 595791 hmuT 2649050 hmuT Corynebacterium diphtheriae NCTC 13129 Iron-related transport system receptor protein NP_939000.1 594730 D 257309 CDS NP_939001.1 38233234 2649051 595775..596827 1 NC_002935.2 Almost identical to previously sequenced Corynebacterium diphtheriae HmuU TR:Q9XD88 (EMBL:AF109162) (350 aa) fasta scores: E(): 6.1e-120, 98% id in 350 aa, and highly similar to Corynebacterium ulcerans permease HmuU TR:Q9EZ56 (EMBL:AF304009) (350 aa) fasta scores: E(): 4.3e-100, 81.14% id in 350 aa; Iron-related transport system membrane protein 596827 hmuU 2649051 hmuU Corynebacterium diphtheriae NCTC 13129 Iron-related transport system membrane protein NP_939001.1 595775 D 257309 CDS NP_939002.1 38233235 2649052 596848..597681 1 NC_002935.2 Almost identical to the previously sequenced Corynebacterium diphtheriae HmuV TR:Q9XD87 (EMBL:AF109162) (277 aa) fasta scores: E(): 3.2e-88, 97.83% id in 277 aa, and to Escherichia coli iron (III) dicitrate transport ATP-binding protein FecE or B4287 SW:FECE_ECOLI (P15031) (255 aa) fasta scores: E(): 1.2e-23, 41.94% id in 236 aa; Iron-related transport system ATP-binding protein 597681 hmuV 2649052 hmuV Corynebacterium diphtheriae NCTC 13129 Iron-related transport system ATP-binding protein NP_939002.1 596848 D 257309 CDS NP_939003.1 38233236 2649053 597871..598848 1 NC_002935.2 Almost identical to previously sequenced Corynebacterium diphtheriae secreted protein precursor TR:Q9XD85 (EMBL:AF109162) (339 aa) fasta scores: E(): 2.9e-99, 89.21% id in 306 aa; hypothetical protein 598848 2649053 DIP0629 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939003.1 597871 D 257309 CDS NP_939004.1 38233237 2649054 complement(598958..600274) 1 NC_002935.2 catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; O-acetylhomoserine aminocarboxypropyltransferase 600274 2649054 DIP0630 Corynebacterium diphtheriae NCTC 13129 O-acetylhomoserine aminocarboxypropyltransferase NP_939004.1 598958 R 257309 CDS NP_939005.1 38233238 2649055 complement(600526..602739) 1 NC_002935.2 Highly similar to Corynebacterium glutamicum isocitrate dehydrogenase [NADP] Icd SW:IDH_CORGL (P50216) (738 aa) fasta scores: E(): 0, 83.31% id in 737 aa; isocitrate dehydrogenase 602739 icd 2649055 icd Corynebacterium diphtheriae NCTC 13129 isocitrate dehydrogenase NP_939005.1 600526 R 257309 CDS NP_939006.1 38233239 2649056 602928..604208 1 NC_002935.2 Similar to Rhizobium meliloti transport transmembrane protein SMC02161 TR:CAC41922 (EMBL:AL591783) (411 aa) fasta scores: E(): 5.7e-56, 46.61% id in 384 aa, and to Streptomyces coelicolor transmembrane efflux protein SC1G2.16c TR:Q9RDR3 (EMBL:AL136500) (413 aa) fasta scores: E(): 4.7e-46, 41.62% id in 370 aa; hypothetical protein 604208 2649056 DIP0632 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939006.1 602928 D 257309 CDS NP_939007.1 38233240 2649057 604219..605124 1 NC_002935.2 Similar to Streptomyces coelicolor exodeoxyribonuclease SCE87.25c TR:Q9RKB3 (EMBL:AL132674) (274 aa) fasta scores: E(): 2.6e-27, 44.3% id in 307 aa; exodeoxyribonuclease 605124 2649057 DIP0633 Corynebacterium diphtheriae NCTC 13129 exodeoxyribonuclease NP_939007.1 604219 D 257309 CDS NP_939008.1 38233241 2649945 605270..605449 1 NC_002935.2 hypothetical protein 605449 2649945 DIP0634 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939008.1 605270 D 257309 CDS NP_939009.1 38233242 2649946 605642..606676 1 NC_002935.2 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 606676 trpS 2649946 trpS Corynebacterium diphtheriae NCTC 13129 tryptophanyl-tRNA synthetase NP_939009.1 605642 D 257309 CDS NP_939010.1 38233243 2649947 606805..607965 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3439 TR:AAK47783 (EMBL:AE007151) (289 aa) fasta scores: E(): 1.6e-33, 33.91% id in 286 aa; hypothetical protein 607965 2649947 DIP0636 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939010.1 606805 D 257309 CDS NP_939011.1 38233244 2649948 complement(608070..609302) 1 NC_002935.2 Similar to Mycobacterium leprae D-alanyl-D-alanine carboxypeptidase ML0691 TR:Q9CCM2 (EMBL:AL583919) (411 aa) fasta scores: E(): 6.2e-45, 40.1% id in 389 aa, and to Bacillus subtilis penicillin-binding protein 5* precursor DacB SW:DACB_BACSU (P35150) (382 aa) fasta scores: E(): 2e-13, 30.26% id in 261 aa; peptidoglycan synthesis-like protein 609302 2649948 DIP0637 Corynebacterium diphtheriae NCTC 13129 peptidoglycan synthesis-like protein NP_939011.1 608070 R 257309 CDS NP_939012.1 38233245 2649949 609337..610281 1 NC_002935.2 Low similarity to C-terminal region of Streptomyces coelicolor adenosine deaminase SC5H1.24c TR:Q9X7T2 (EMBL:AL049863) (359 aa) fasta scores: E(): 2.1e-06, 28.88% id in 225 aa; hypothetical protein 610281 2649949 DIP0638 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939012.1 609337 D 257309 CDS NP_939013.1 38233246 2649950 complement(610555..611787) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 45.7 kDa protein Rv3311 or MTV016.10 TR:O53362 (EMBL:AL021841) (420 aa) fasta scores: E(): 1.4e-25, 34.05% id in 417 aa; hypothetical protein 611787 2649950 DIP0639 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939013.1 610555 R 257309 CDS NP_939014.1 38233247 2649951 complement(611808..612647) 1 NC_002935.2 C-terminal region similar to C-terminal region of Mycobacterium leprae secreted protein ML0885 or MLCB268.32c TR:O69580 (EMBL:AL022602) (374 aa) fasta scores: E(): 4.6e-12, 37.57% id in 173 aa; hypothetical protein 612647 2649951 DIP0640 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939014.1 611808 R 257309 CDS NP_939015.1 38233248 2649952 complement(612644..612925) 1 NC_002935.2 hypothetical protein 612925 2649952 DIP0641 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939015.1 612644 R 257309 CDS NP_939016.1 38233249 2649953 612990..613625 1 NC_002935.2 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 613625 upp 2649953 upp Corynebacterium diphtheriae NCTC 13129 uracil phosphoribosyltransferase NP_939016.1 612990 D 257309 CDS NP_939017.1 38233250 2649954 613790..614371 1 NC_002935.2 DNA-binding protein 614371 2649954 DIP0643 Corynebacterium diphtheriae NCTC 13129 DNA-binding protein NP_939017.1 613790 D 257309 CDS NP_939018.1 38233251 2649955 614468..615658 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 hydrolase, Ama/HipO/HyuC family MT3404 TR:AAK47747 (EMBL:AE007149) (389 aa) fasta scores: E(): 4.5e-74, 49.74% id in 388 aa; hypothetical protein 615658 2649955 DIP0644 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939018.1 614468 D 257309 CDS NP_939019.1 38233252 2649956 615701..617173 1 NC_002935.2 catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity; flavoprotein disulfide reductase 617173 lpdA 2649956 lpdA Corynebacterium diphtheriae NCTC 13129 flavoprotein disulfide reductase NP_939019.1 615701 D 257309 CDS NP_939020.1 38233253 2649499 617693..621118 1 NC_002935.2 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate; pyruvate carboxylase 621118 pyc 2649499 pyc Corynebacterium diphtheriae NCTC 13129 pyruvate carboxylase NP_939020.1 617693 D 257309 CDS NP_939021.1 38233254 2649500 complement(621208..621972) 1 NC_002935.2 Similar to Streptococcus pyogenes hypothetical protein SPY1216 TR:Q99ZI6 (EMBL:AE006562) (270 aa) fasta scores: E(): 3.2e-07, 33.82% id in 136 aa; hypothetical protein 621972 2649500 DIP0647 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939021.1 621208 R 257309 CDS NP_939022.1 38233255 2649501 complement(621987..622391) 1 NC_002935.2 hypothetical protein 622391 2649501 DIP0648 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939022.1 621987 R 257309 CDS NP_939023.1 38233256 2649502 complement(622563..624347) 1 NC_002935.2 Similar to Corynebacterium glutamicum acyl coenzyme A carboxylase AccBC TR:P71122 (EMBL:U35023) (591 aa) fasta scores: E(): 1.5e-188, 85.47% id in 592 aa, and to Mycobacterium leprae acetyl-/propionyl-coenzyme A carboxylase alpha chain [includes: biotin carboxylase ; biotin carboxyl carrier protein(BCCP)] BccA or ML0726 or B1308_C1_129 SW:BCCA_MYCLE (P46392) (598 aa) fasta scores: E(): 1.1e-159, 72.46% id in 592 aa; acyl coenzyme A carboxylase 624347 accBC 2649502 accBC Corynebacterium diphtheriae NCTC 13129 acyl coenzyme A carboxylase NP_939023.1 622563 R 257309 CDS NP_939024.1 38233257 2649503 complement(624604..625485) 1 NC_002935.2 Similar to Mycobacterium tuberculosis thiosulfate sulfurtransferase SseA or Rv3283 or MT3382 or MTCY71.23 SW:THT2_MYCTU (P96888) (297 aa) fasta scores: E(): 1.5e-78, 60.67% id in 295 aa, and to Corynebacterium glutamicum thiosulfate sulfurtransferase ThtR SW:THTR_CORGL (P71121) (225 aa) fasta scores: E(): 1.2e-56, 63.72% id in 215 aa; thiosulfate sulfurtransferase 625485 sseA 2649503 sseA Corynebacterium diphtheriae NCTC 13129 thiosulfate sulfurtransferase NP_939024.1 624604 R 257309 CDS NP_939025.1 38233258 2650227 626082..627140 1 NC_002935.2 Similar to Campylobacter jejuni hypothetical protein CJ0069 TR:Q9PJ50 (EMBL:AL139074) (343 aa) fasta scores: E(): 3e-85, 61.36% id in 352 aa; hypothetical protein 627140 2650227 DIP0651 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939025.1 626082 D 257309 CDS NP_939026.1 38233259 2650228 627335..629452 1 NC_002935.2 Similar to Mycobacterium leprae conserved membrane protein ML1213 TR:Q9CC68 (EMBL:AL583921) (733 aa) fasta scores: E(): 1.2e-78, 38.27% id in 708 aa; hypothetical protein 629452 2650228 DIP0652 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939026.1 627335 D 257309 CDS NP_939027.1 38233260 2650229 complement(629449..629877) 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical 14.5 kDa protein ML0284 or MLCB4.27c TR:O69598 (EMBL:AL023514) (137 aa) fasta scores: E(): 3.5e-22, 50% id in 140 aa; hypothetical protein 629877 2650229 DIP0653 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939027.1 629449 R 257309 CDS NP_939028.1 38233261 2650230 complement(629879..630475) 1 NC_002935.2 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 630475 maf 2650230 maf Corynebacterium diphtheriae NCTC 13129 Maf-like protein NP_939028.1 629879 R 257309 CDS NP_939029.1 38233262 2650231 complement(630494..631399) 1 NC_002935.2 Similar to Streptomyces coelicolor carbohydrate kinase SCC57A.19 TR:Q9RDH9 (EMBL:AL136519) (306 aa) fasta scores: E(): 1.3e-32, 44.06% id in 295 aa, and to Escherichia coli ribokinase RbsK or B3752 or Z5253 or ECS4694 SW:RBSK_ECOLI (P05054) (309 aa) fasta scores: E(): 4.3e-24, 35.69% id in 297 aa; ribokinase 631399 2650231 DIP0655 Corynebacterium diphtheriae NCTC 13129 ribokinase NP_939029.1 630494 R 257309 CDS NP_939030.1 38233263 2650232 complement(631544..632599) 1 NC_002935.2 Similar to Streptomyces coelicolor probable lacI-family transcriptional regulator SCC57A.16 TR:Q9RDI2 (EMBL:AL136519) (347 aa) fasta scores: E(): 5.5e-32, 34.04% id in 326 aa, and to Bacillus megaterium glucose-resistance amylase regulator CcpA SW:CCPA_BACME (P46828) (332 aa) fasta scores: E(): 5.1e-24, 29.17% id in 329 aa; transcriptional regulator 632599 2650232 DIP0656 Corynebacterium diphtheriae NCTC 13129 transcriptional regulator NP_939030.1 631544 R 257309 CDS NP_939031.1 38233264 2650233 complement(632991..633251) 1 NC_002935.2 hypothetical protein 633251 2650233 DIP0657 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939031.1 632991 R 257309 CDS NP_939032.1 38233265 2650234 complement(633347..634978) 1 NC_002935.2 Similar to Corynebacterium glutamicum DtsR2 protein TR:O87201 (EMBL:AB018531) (537 aa) fasta scores: E(): 2e-182, 87.87% id in 536 aa, and to Saccharopolyspora erythraea propionyl-CoA carboxylase beta chain PccB SW:PCCB_SACER (P53003) (546 aa) fasta scores: E(): 5.2e-137, 64.83% id in 546 aa. Possible duplication of DIP0660 (69.309% identity in 492 aa overlap); propionyl CoA carboxylase subunitbeta 634978 pccB1 2650234 pccB1 Corynebacterium diphtheriae NCTC 13129 propionyl CoA carboxylase subunitbeta NP_939032.1 633347 R 257309 CDS NP_939033.1 38233266 2650235 635607..636701 1 NC_002935.2 hypothetical protein 636701 2650235 DIP0659 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939033.1 635607 D 257309 CDS NP_939034.1 38233267 2650236 complement(636944..638575) 1 NC_002935.2 Similar to Corynebacterium glutamicum DtsR1 protein TR:O88155 (EMBL:AB018531) (543 aa) fasta scores: E(): 1.5e-173, 81.76% id in 543 aa, and to Saccharopolyspora erythraea propionyl-CoA carboxylase beta chain PccB SW:PCCB_SACER (P53003) (546 aa) fasta scores: E(): 2.7e-127, 59.89% id in 546 aa. Possible duplication of DIP0658 (69.309% identity in 492 aa overlap); propionyl-CoA carboxylase subunit beta 638575 pccB2 2650236 pccB2 Corynebacterium diphtheriae NCTC 13129 propionyl-CoA carboxylase subunit beta NP_939034.1 636944 R 257309 CDS NP_939035.1 38233268 2650237 638727..639527 1 NC_002935.2 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 639527 2650237 DIP0661 Corynebacterium diphtheriae NCTC 13129 biotin--protein ligase NP_939035.1 638727 D 257309 CDS NP_939036.1 38233269 2650238 639528..639992 1 NC_002935.2 hypothetical protein 639992 2650238 DIP0662 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939036.1 639528 D 257309 CDS NP_939037.1 38233270 2650239 640046..641251 1 NC_002935.2 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 641251 purK 2650239 purK Corynebacterium diphtheriae NCTC 13129 phosphoribosylaminoimidazole carboxylase ATPase subunit NP_939037.1 640046 D 257309 CDS NP_939038.1 38233271 2650240 641251..641751 1 NC_002935.2 Catalyzes a step in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase catalytic subunit 641751 purE 2650240 purE Corynebacterium diphtheriae NCTC 13129 phosphoribosylaminoimidazole carboxylase catalytic subunit NP_939038.1 641251 D 257309 CDS NP_939039.1 38233272 2650241 641756..642217 1 NC_002935.2 Similar to the C-terminal region of Lactococcus lactis hypothetical protein YebE TR:Q9CIF2 (EMBL:AE006277) (194 aa) fasta scores: E(): 2.7e-05, 36.76% id in 136 aa; hypothetical protein 642217 2650241 DIP0665 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939039.1 641756 D 257309 CDS NP_939040.1 38233273 2650863 complement(642209..643324) 1 NC_002935.2 Similar to Escherichia coli hydrogenase isoenzymes formation protein HypD or B2729 SW:HYPD_ECOLI (P24192) (373 aa) fasta scores: E(): 4.1e-77, 51.73% id in 375 aa, and to Nostoc punctiforme HypD-like protein TR:Q9EYH5 (EMBL:AF325724) (392 aa) fasta scores: E(): 8.7e-94, 58.74% id in 366 aa; hydrogenase isoenzyme formation protein 643324 hypD 2650863 hypD Corynebacterium diphtheriae NCTC 13129 hydrogenase isoenzyme formation protein NP_939040.1 642209 R 257309 CDS NP_939041.1 38233274 2650864 complement(643324..643581) 1 NC_002935.2 Similar to Rhodobacter capsulatus hydrogenase expression/formation protein HypC SW:HYPC_RHOCA (P40428) (96 aa) fasta scores: E(): 4.7e-09, 50% id in 82 aa, and to Escherichia coli hydrogenase-2 operon protein HybG or B2990 or Z4344 or ECS3875 SW:HYBG_ECOLI (P37185) (82 aa) fasta scores: E(): 8e-08, 44% id in 75 aa; hydrogenase expression/formation protein HypC 643581 hypC 2650864 hypC Corynebacterium diphtheriae NCTC 13129 hydrogenase expression/formation protein HypC NP_939041.1 643324 R 257309 CDS NP_939042.1 38233275 2650865 643639..644709 1 NC_002935.2 Similar to Rhodobacter capsulatus hydrogenase expression/formation protein HypE SW:HYPE_RHOCA (P26412) (340 aa) fasta scores: E(): 8e-46, 49.7% id in 336 aa, and to Escherichia coli hydrogenase isoenzymes formation protein HypE or B2730 SW:HYPE_ECOLI (P24193) (322 aa) fasta scores: E(): 5.7e-38, 43.03% id in 323 aa; hydrogenase expression/formation protein HypE 644709 hypE 2650865 hypE Corynebacterium diphtheriae NCTC 13129 hydrogenase expression/formation protein HypE NP_939042.1 643639 D 257309 CDS NP_939043.1 38233276 2648478 complement(644718..646952) 1 NC_002935.2 Similar to Azotobacter chroococcum MCD 1 hydrogenase maturation protein HypF or HupY SW:HYPF_AZOCH (Q43950) (776 aa) fasta scores: E(): 2.5e-73, 37.62% id in 784 aa, and to Escherichia coli hydrogenase maturation protein HypF or HydA or B2712 SW:HYPF_ECOLI (P30131) (750 aa) fasta scores: E(): 1e-43, 38.82% id in 765 aa; hydrogenase maturation protein 646952 2648478 DIP0669 Corynebacterium diphtheriae NCTC 13129 hydrogenase maturation protein NP_939043.1 644718 R 257309 CDS NP_939044.1 38233277 2649632 646965..647303 1 NC_002935.2 Similar to Nostoc punctiforme hydrogenase nickel incorporation protein HypA SW:HYPA_NOSPU (Q9EYH3) (113 aa) fasta scores: E(): 4.6e-06, 30.35% id in 112 aa, and to Rhodobacter capsulatus hydrogenase nickel incorporation protein HypA or HupL SW:HYPA_RHOCA (P26409) (113 aa) fasta scores: E(): 0.0006, 27.67% id in 112 aa; hydrogenase nickel incorporation protein 647303 2649632 DIP0670 Corynebacterium diphtheriae NCTC 13129 hydrogenase nickel incorporation protein NP_939044.1 646965 D 257309 CDS NP_939045.1 38233278 2649633 647316..648077 1 NC_002935.2 Similar to Rhodobacter capsulatus hydrogenase nickel incorporation protein HypB or HupM SW:HYPB_RHOCA (P26410) (335 aa) fasta scores: E(): 1.3e-34, 45.78% id in 249 aa, and to Escherichia coli hydrogenase isoenzymes nickel incorporation protein HypB or B2727 SW:HYPB_ECOLI (P24190) (290 aa) fasta scores: E(): 7.4e-34, 44.58% id in 231 aa; hydrogenase nickel incorporation protein 648077 2649633 DIP0671 Corynebacterium diphtheriae NCTC 13129 hydrogenase nickel incorporation protein NP_939045.1 647316 D 257309 CDS NP_939046.1 38233279 2649634 648378..649634 1 NC_002935.2 Similar to Azotobacter vinelandii uptake hydrogenase small subunit precursor HoxK SW:MBHS_AZOVI (P21950) (358 aa) fasta scores: E(): 4.6e-64, 45.75% id in 365 aa, and to Escherichia coli hydrogenase-1 small chain precursor HyaA or B0972 SW:MBHS_ECOLI (P19928) (372 aa) fasta scores: E(): 1.3e-58, 42.54% id in 369 aa; uptake hydrogenase small subunit 649634 2649634 DIP0672 Corynebacterium diphtheriae NCTC 13129 uptake hydrogenase small subunit NP_939046.1 648378 D 257309 CDS NP_939047.1 38233280 2649635 649640..651385 1 NC_002935.2 Similar to Bradyrhizobium japonicum uptake hydrogenase large subunit HupB or HupL SW:MBHL_BRAJA (P12636) (596 aa) fasta scores: E(): 2.8e-98, 45% id in 591 aa, and to Escherichia coli hydrogenase-1 large chain HyaB or B0973 SW:MBHL_ECOLI (P19927) (597 aa) fasta scores: E(): 2.5e-91, 41.25% id in 589 aa; uptake hydrogenase large subunit 651385 2649635 DIP0673 Corynebacterium diphtheriae NCTC 13129 uptake hydrogenase large subunit NP_939047.1 649640 D 257309 CDS NP_939048.1 38233281 2649636 651382..652536 1 NC_002935.2 Similar to Bradyrhizobium japonicum probable Ni/Fe-hydrogenase B-type cytochrome subunit HupC SW:CYBH_BRAJA (P21960) (244 aa) fasta scores: E(): 2.3e-16, 32.65% id in 245 aa, and to Escherichia coli probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit HyaC or B0974 or Z1391 or ECS1130 SW:CYBH_ECOLI (P19929) (235 aa) fasta scores: E(): 6e-13, 30.04% id in 213 aa and N-terminal region similar to Homo sapiens vacuolar proton translocating ATPase 116 kDa subunit A isoform 2 SW:VPP2_HUMAN (Q9Y487) blast scores: E(): 2.6, score: 34 30% id; Ni/Fe-hydrogenase B-type cytochrome subunit 652536 2649636 DIP0674 Corynebacterium diphtheriae NCTC 13129 Ni/Fe-hydrogenase B-type cytochrome subunit NP_939048.1 651382 D 257309 CDS NP_939049.1 38233282 2649637 652547..653059 1 NC_002935.2 Similar to Escherichia coli hydrogenase 2 maturation protease HybD or B2993 SW:HYBD_ECOLI (P37182) (164 aa) fasta scores: E(): 6.6e-12, 34.88% id in 172 aa; hydrogenase maturation protease 653059 2649637 DIP0675 Corynebacterium diphtheriae NCTC 13129 hydrogenase maturation protease NP_939049.1 652547 D 257309 CDS NP_939050.1 38233283 2649638 complement(653056..653421) 1 NC_002935.2 Similar to Bradyrhizobium japonicum hydrogenase nickel incorporation protein HypA SW:HYPA_BRAJA (Q45256) (113 aa) fasta scores: E(): 4e-06, 28.07% id in 114 aa; hydrogenase nickel incorporation protein 653421 2649638 DIP0676 Corynebacterium diphtheriae NCTC 13129 hydrogenase nickel incorporation protein NP_939050.1 653056 R 257309 CDS NP_939051.1 38233284 2649639 653448..654491 1 NC_002935.2 Similar to Methanococcus voltae methylviologen-reducing hydrogenase Vhu alpha subunit VhuA TR:Q00407 (EMBL:X61204) (420 aa) fasta scores: E(): 9e-06, 24.37% id in 398 aa; reducing hydrogenase subunit alpha 654491 2649639 DIP0677 Corynebacterium diphtheriae NCTC 13129 reducing hydrogenase subunit alpha NP_939051.1 653448 D 257309 CDS NP_939052.1 38233285 2650259 654497..654754 1 NC_002935.2 Similar to Azotobacter vinelandii probable hydrogenase expression/formation protein HypC or HupF SW:HYPC_AZOVI (P31881) (84 aa) fasta scores: E(): 8.5e-06, 36.25% id in 80 aa, and to Escherichia coli hydrogenase-2 operon protein HybG or B2990 or Z4344 or ECS3875 SW:HYBG_ECOLI (P37185) (82 aa) fasta scores: E(): 0.0017, 28.94% id in 76 aa; hydrogenase operon protein 654754 2650259 DIP0678 Corynebacterium diphtheriae NCTC 13129 hydrogenase operon protein NP_939052.1 654497 D 257309 CDS NP_939053.1 38233286 2650260 complement(654751..655413) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 23.7 kDa protein Rv3268 or MTCY71.08 TR:P96873 (EMBL:Z92771) (229 aa) fasta scores: E(): 7.6e-11, 31.48% id in 235 aa; hypothetical protein 655413 2650260 DIP0679 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939053.1 654751 R 257309 CDS NP_939054.1 38233287 2650261 complement(655425..656903) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3367 TR:AAK47708 (EMBL:AE007146) (497 aa) fasta scores: E(): 6e-73, 50.1% id in 469 aa; hypothetical protein 656903 2650261 DIP0680 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939054.1 655425 R 257309 CDS NP_939055.1 38233288 2650262 657162..658052 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 glycosyl transferase MT3365 TR:AAK47706 (EMBL:AE007146) (301 aa) fasta scores: E(): 5.1e-56, 52.12% id in 282 aa; glycosyl transferase family protein 658052 2650262 DIP0681 Corynebacterium diphtheriae NCTC 13129 glycosyl transferase family protein NP_939055.1 657162 D 257309 CDS NP_939056.1 38233289 2650263 658206..659294 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 mannose-1-phosphate guanyltransferase MT3364 TR:AAK47705 (EMBL:AE007146) (359 aa) fasta scores: E(): 1e-93, 70.45% id in 352 aa; mannose-1-phosphate guanylyltransferase 659294 2650263 DIP0682 Corynebacterium diphtheriae NCTC 13129 mannose-1-phosphate guanylyltransferase NP_939056.1 658206 D 257309 CDS NP_939057.1 38233290 2650264 659420..659557 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 659557 2650264 DIP0683 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939057.1 659420 D 257309 CDS NP_939058.1 38233291 2650265 659753..660052 1 NC_002935.2 Highly similar on its C-terminal region to the C-terminal region of Streptomyces coelicolor regulatory protein WhiB TR:Q53963 (EMBL:X62287) (87 aa) fasta scores: E(): 2.4e-22, 82.6% id in 69 aa; regulatory protein 660052 2650265 DIP0684 Corynebacterium diphtheriae NCTC 13129 regulatory protein NP_939058.1 659753 D 257309 CDS NP_939059.1 38233292 2650266 complement(660126..660581) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 15.6 kDa protein Rv3259 or MTV015.04 TR:O53352 (EMBL:AL021840) (139 aa) fasta scores: E(): 4.2e-21, 50% id in 136 aa; hypothetical protein 660581 2650266 DIP0685 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939059.1 660126 R 257309 CDS NP_939060.1 38233293 2650267 660680..661093 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 hypothetical 16.8 kDa protein MT3356 TR:AAK47698 (EMBL:AE007146) (163 aa) fasta scores: E(): 8.5e-16, 47.65% id in 149 aa; hypothetical protein 661093 2650267 DIP0686 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939060.1 660680 D 257309 CDS NP_939061.1 38233294 2650268 661191..662567 1 NC_002935.2 converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells; phosphomannomutase 662567 manB 2650268 manB Corynebacterium diphtheriae NCTC 13129 phosphomannomutase NP_939061.1 661191 D 257309 CDS NP_939062.1 38233295 2650269 662616..663623 1 NC_002935.2 Similar in its N-terminal region to Mycobacterium tuberculosis hypothetical 35.3 kDa protein Rv3256c or MTV015.01c or MTCY20b11.31c TR:O05899 (EMBL:Z95121) (346 aa) fasta scores: E(): 5.1e-06, 27.69% id in 260 aa; hypothetical protein 663623 2650269 DIP0688 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939062.1 662616 D 257309 CDS NP_939063.1 38233296 2650270 663663..664832 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 mannose-6-phosphate isomerase MT3353 TR:AAK47695 (EMBL:AE007145) (408 aa) fasta scores: E(): 1.6e-57, 47.43% id in 409 aa, and to Escherichia coli mannose-6-phosphate isomerase ManA or Pmi or B1613 SW:MANA_ECOLI (P00946) (391 aa) fasta scores: E(): 1.7e-24, 38.34% id in 399 aa; mannose-phosphate isomerase 664832 2650270 DIP0689 Corynebacterium diphtheriae NCTC 13129 mannose-phosphate isomerase NP_939063.1 663663 D 257309 CDS NP_939064.1 38233297 2650086 complement(664858..665709) 1 NC_002935.2 No significant database matches. Contains various regions with high content in proline amino acid residues; hypothetical protein 665709 2650086 DIP0690 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939064.1 664858 R 257309 CDS NP_939065.1 38233298 2650625 666050..666403 1 NC_002935.2 hypothetical protein 666403 2650625 DIP0691 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939065.1 666050 D 257309 CDS NP_939066.1 38233299 2650626 666509..667945 1 NC_002935.2 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine; S-adenosyl-L-homocysteine hydrolase 667945 ahcY 2650626 ahcY Corynebacterium diphtheriae NCTC 13129 S-adenosyl-L-homocysteine hydrolase NP_939066.1 666509 D 257309 CDS NP_939067.1 38233300 2650627 667945..668562 1 NC_002935.2 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 668562 2650627 DIP0693 Corynebacterium diphtheriae NCTC 13129 thymidylate kinase NP_939067.1 667945 D 257309 CDS NP_939068.1 38233301 2649077 668619..669317 1 NC_002935.2 Similar to Mycobacterium tuberculosis MtrA protein or Rv3246c or MTCY20B11.21c TR:Q50447 (EMBL:Z95121) (228 aa) fasta scores: E(): 7.6e-61, 70.66% id in 225 aa, and to Streptomyces coelicolor transcriptional regulatory protein AfsQ1 or 2SCK8.33c SW:AFQ1_STRCO (Q04942) (225 aa) fasta scores: E(): 2.4e-36, 45.2% id in 219 aa; two component system response regulator 669317 mtrA2 2649077 mtrA2 Corynebacterium diphtheriae NCTC 13129 two component system response regulator NP_939068.1 668619 D 257309 CDS NP_939069.1 38233302 2649078 669450..670892 1 NC_002935.2 Similar to Mycobacterium tuberculosis MtrB or Rv3245c or MTCY20B11.20c TR:O05890 (EMBL:Z95121) (567 aa) fasta scores: E(): 4.6e-89, 53.73% id in 482 aa, and to Streptomyces coelicolor sensor protein AfsQ2 or 2SCK8.32c SW:AFQ2_STRCO (Q04943) (535 aa) fasta scores: E(): 1.4e-23, 30.64% id in 447 aa; two component system sensor kinase 670892 mtrB 2649078 mtrB Corynebacterium diphtheriae NCTC 13129 two component system sensor kinase NP_939069.1 669450 D 257309 CDS NP_939070.1 38233303 2649079 670885..672630 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 61.2 kDa protein LpqB or Rv3244c or MTCY20B11.19c TR:O05889 (EMBL:Z95121) (583 aa) fasta scores: E(): 1.6e-14, 28.76% id in 591 aa; lipoprotein LpqB 672630 2649079 DIP0696 Corynebacterium diphtheriae NCTC 13129 lipoprotein LpqB NP_939070.1 670885 D 257309 CDS NP_939071.1 38233304 2649080 672652..673254 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 22.5 kDa protein Rv3242c or MTCY20B11.17c TR:O05887 (EMBL:Z95121) (213 aa) fasta scores: E(): 8.3e-21, 41.5% id in 212 aa; hypothetical protein 673254 2649080 DIP0697 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939071.1 672652 D 257309 CDS NP_939072.1 38233305 2649081 673384..674052 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical protein ML0778 TR:Q9CCI7 (EMBL:AL583919) (229 aa) fasta scores: E(): 4.6e-35, 48.41% id in 221 aa; hypothetical protein 674052 2649081 DIP0698 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939072.1 673384 D 257309 CDS NP_939073.1 38233306 2649082 674230..676791 1 NC_002935.2 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 676791 secA 2649082 secA Corynebacterium diphtheriae NCTC 13129 preprotein translocase subunit SecA NP_939073.1 674230 D 257309 CDS NP_939074.1 38233307 2649083 676843..677046 1 NC_002935.2 hypothetical protein 677046 2649083 DIP0700 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939074.1 676843 D 257309 CDS NP_939075.1 38233308 2649084 677455..677865 1 NC_002935.2 Similar to C-terminal region of Mycobacterium tuberculosis CDC1551 hydrolase, haloacid dehalogenase-like family MT3486 TR:AAK47822 (EMBL:AE007155) (217 aa) fasta scores: E(): 0.0053, 32.35% id in 136 aa; hypothetical protein 677865 2649084 DIP0701 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939075.1 677455 D 257309 CDS NP_939076.1 38233309 2649085 677877..678383 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 17.8 kDa protein Rv3231c or MTCY20B11.06c TR:O05876 (EMBL:Z95121) (169 aa) fasta scores: E(): 2.4e-25, 53.52% id in 170 aa; hypothetical protein 678383 2649085 DIP0702 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939076.1 677877 D 257309 CDS NP_939077.1 38233310 2649086 678605..679675 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 40.8 kDa protein Rv3230c or MTCY20B11.05c TR:O05875 (EMBL:Z95121) (380 aa) fasta scores: E(): 4.8e-60, 49.14% id in 350 aa, and to Escherichia coli NADH oxidoreductase Hcr or B0872 SW:HCR_ECOLI (P75824) (322 aa) fasta scores: E(): 1.9e-13, 28.71% id in 296 aa; oxidoreductase 679675 2649086 DIP0703 Corynebacterium diphtheriae NCTC 13129 oxidoreductase NP_939077.1 678605 D 257309 CDS NP_939078.1 38233311 2649087 679690..680970 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 48.4 kDa protein DesA3 or Rv3229c or MTCY20B11.04c TR:O05874 (EMBL:Z95121) (427 aa) fasta scores: E(): 1.5e-86, 52.59% id in 405 aa; hypothetical protein 680970 2649087 DIP0704 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939078.1 679690 D 257309 CDS NP_939079.1 38233312 2649088 complement(680972..681979) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 34.9 kDa protein Rv3228 or MTCY20B11.03 TR:O05873 (EMBL:Z95121) (330 aa) fasta scores: E(): 9.1e-70, 60.18% id in 324 aa; hypothetical protein 681979 2649088 DIP0705 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939079.1 680972 R 257309 CDS NP_939080.1 38233313 2649089 complement(681984..683279) 1 NC_002935.2 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 683279 aroA 2649089 aroA Corynebacterium diphtheriae NCTC 13129 3-phosphoshikimate 1-carboxyvinyltransferase NP_939080.1 681984 R 257309 CDS NP_939081.1 38233314 2650208 683297..683959 1 NC_002935.2 Similar to Halobacterium sp VNG0686c TR:Q9HRI0 (EMBL:AE005014) (229 aa) fasta scores: E(): 4.5e-12, 35.51% id in 245 aa; hypothetical protein 683959 2650208 DIP0707 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939081.1 683297 D 257309 CDS NP_939082.1 38233315 2650209 complement(683945..684448) 1 NC_002935.2 Similar to Escherichia coli protein YbaK or B0481 SW:YBAK_ECOLI (P37175) (159 aa) fasta scores: E(): 1.2e-21, 46.49% id in 157 aa; hypothetical protein 684448 2650209 DIP0708 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939082.1 683945 R 257309 CDS NP_939083.1 38233316 2650210 684494..685117 1 NC_002935.2 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 685117 rpoE 2650210 rpoE Corynebacterium diphtheriae NCTC 13129 RNA polymerase sigma factor RpoE NP_939083.1 684494 D 257309 CDS NP_939084.1 38233317 2650211 685114..685365 1 NC_002935.2 Similar to Streptomyces coelicolor anti-sigma factor RsrA TR:Q9RL96 (EMBL:AJ010320) (105 aa) fasta scores: E(): 5.5e-06, 35.71% id in 70 aa; anti sigma factor 685365 2650211 DIP0710 Corynebacterium diphtheriae NCTC 13129 anti sigma factor NP_939084.1 685114 D 257309 CDS NP_939085.1 38233318 2650212 complement(685370..685714) 1 NC_002935.2 hypothetical protein 685714 2650212 DIP0711 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939085.1 685370 R 257309 CDS NP_939086.1 38233319 2650213 complement(686052..686312) 1 NC_002935.2 Similar to Mycobacterium leprae transcriptional regulator WhiB1 or ML0804 TR:Q9CCH7 (EMBL:AL583919) (84 aa) fasta scores: E(): 1.5e-29, 81.7% id in 82 aa; transcriptional regulator 686312 2650213 DIP0712 Corynebacterium diphtheriae NCTC 13129 transcriptional regulator NP_939086.1 686052 R 257309 CDS NP_939087.1 38233320 2650214 686383..686781 1 NC_002935.2 hypothetical protein 686781 2650214 DIP0713 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939087.1 686383 D 257309 CDS NP_939088.1 38233321 2650215 686945..687406 1 NC_002935.2 Similar to Mycobacterium leprae membrane protein ML0806 TR:Q9CCH6 (EMBL:AL583919) (173 aa) fasta scores: E(): 2e-07, 38.34% id in 133 aa; hypothetical protein 687406 2650215 DIP0715 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939088.1 686945 D 257309 CDS NP_939089.1 38233322 2650216 complement(687400..688662) 1 NC_002935.2 Low similarity to Mycobacterium leprae membrane protein ML0810 TR:Q9CCH4 (EMBL:AL583919) (407 aa) fasta scores: E(): 1.1e-21, 26.81% id in 414 aa; hypothetical protein 688662 2650216 DIP0716 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939089.1 687400 R 257309 CDS NP_939090.1 38233323 2650217 complement(688659..689969) 1 NC_002935.2 Similar to Mycobacterium leprae ATP-dependent RNA helicase RhlE or ML0811 TR:Q9CCH3 (EMBL:AL583919) (544 aa) fasta scores: E(): 2.1e-87, 55.78% id in 441 aa, and to Klebsiella pneumoniae cold-shock dead-box protein A DeaD or CsdA SW:DEAD_KLEPN (P33906) (642 aa) fasta scores: E(): 5.7e-49, 41.91% id in 377 aa; ATP-dependent RNA helicase 689969 2650217 DIP0717 Corynebacterium diphtheriae NCTC 13129 ATP-dependent RNA helicase NP_939090.1 688659 R 257309 CDS NP_939091.1 38233324 2650218 complement(690051..690176) 1 NC_002935.2 Doubtful CDS. No significant database matches; hypothetical protein 690176 2650218 DIP0718 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939091.1 690051 R 257309 CDS NP_939092.1 38233325 2650219 690227..690454 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 hypothetical 10.1 kDa protein MT3304 TR:AAK47646 (EMBL:AE007142) (97 aa) fasta scores: E(): 4.5e-11, 51.38% id in 72 aa; hypothetical protein 690454 2650219 DIP0719 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939092.1 690227 D 257309 CDS NP_939093.1 38233326 2650220 690457..691335 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 31.0 kDa protein Rv3207c or MTCY07D11.19 TR:O05859 (EMBL:Z95120) (285 aa) fasta scores: E(): 1.7e-44, 46.69% id in 287 aa; hypothetical protein 691335 2650220 DIP0720 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939093.1 690457 D 257309 CDS NP_939094.1 38233327 2650221 691359..692216 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical protein ML0818 TR:Q9CCG7 (EMBL:AL583919) (297 aa) fasta scores: E(): 1.2e-34, 39.47% id in 266 aa; hypothetical protein 692216 2650221 DIP0721 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939094.1 691359 D 257309 CDS NP_939095.1 38233328 2650222 692220..695402 1 NC_002935.2 Similar to Streptomyces coelicolor ATP-dependent DNA helicase 2SC3B6.07 TR:Q9FCK5 (EMBL:AL390968) (1159 aa) fasta scores: E(): 6.2e-29, 32.21% id in 1161 aa; ATP-dependent DNA helicase 695402 2650222 DIP0722 Corynebacterium diphtheriae NCTC 13129 ATP-dependent DNA helicase NP_939095.1 692220 D 257309 CDS NP_939096.1 38233329 2650223 695396..698626 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 helicase, UvrD/Rep family MT3295 TR:AAK47638 (EMBL:AE007142) (1101 aa) fasta scores: E(): 2.9e-25, 43.03% id in 1120 aa; helicase 698626 2650223 DIP0723 Corynebacterium diphtheriae NCTC 13129 helicase NP_939096.1 695396 D 257309 CDS NP_939097.1 38233330 2650224 698671..699759 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 transporter, MT3294 TR:AAK47637 (EMBL:AE007142) (355 aa) fasta scores: E(): 2.5e-75, 61.78% id in 348 aa, and to Escherichia coli potassium channel protein Kch or B1250 SW:KCH_ECOLI (P31069) (417 aa) fasta scores: E(): 1.5e-07, 26.06% id in 234 aa; membrane transporter 699759 2650224 DIP0724 Corynebacterium diphtheriae NCTC 13129 membrane transporter NP_939097.1 698671 D 257309 CDS NP_939098.1 38233331 2650225 699791..700474 1 NC_002935.2 Similar to C-terminal region of Vibrio cholerae NADH pyrophosphatase NudC or VC0331 SW:NUDC_VIBCH (Q9KV27) (269 aa) fasta scores: E(): 2.3e-11, 32.75% id in 174 aa; hydrolase 700474 2650225 DIP0725 Corynebacterium diphtheriae NCTC 13129 hydrolase NP_939098.1 699791 D 257309 CDS NP_939099.1 38233332 2650226 700467..702518 1 NC_002935.2 Similar to Mycobacterium tuberculosis probable DNA helicase II homolog UvrD or Rv3198c or MT3291 or MTV014.42c SW:UVRD_MYCTU (O53344) (700 aa) fasta scores: E(): 2.7e-133, 58.92% id in 689 aa, and to Escherichia coli DNA helicase II UvrD or MutU or PdeB or Rad or RecL or B3813 SW:UVRD_ECOLI (P03018) (720 aa) fasta scores: E(): 7.8e-37, 32.16% id in 656 aa; DNA helicase II 702518 uvrD 2650226 uvrD Corynebacterium diphtheriae NCTC 13129 DNA helicase II NP_939099.1 700467 D 257309 CDS NP_939100.1 38233333 2649309 complement(702463..703362) 1 NC_002935.2 Low similarity to Mycobacterium tuberculosis CDC1551 hypothetical 31.6 kDa protein MT3288 TR:AAK47629 (EMBL:AE007141) (299 aa) fasta scores: E(): 3.9e-06, 28.12% id in 288 aa; hypothetical protein 703362 2649309 DIP0727 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939100.1 702463 R 257309 CDS NP_939101.1 38233334 2649310 703392..703913 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 19.2 kDa protein 2SC3B6.18 TR:Q9FCJ4 (EMBL:AL390968) (168 aa) fasta scores: E(): 2e-25, 46% id in 150 aa; hypothetical protein 703913 2649310 DIP0728 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939101.1 703392 D 257309 CDS NP_939102.1 38233335 2649311 complement(703910..705301) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 49.4 kDa protein Rv3195 or MTV014.39 TR:O53341 (EMBL:AL021646) (472 aa) fasta scores: E(): 5.1e-65, 45.37% id in 432 aa; hypothetical protein 705301 2649311 DIP0729 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939102.1 703910 R 257309 CDS NP_939103.1 38233336 2649312 705382..706434 1 NC_002935.2 Similar to Mycobacterium leprae secreted protein ML0643 TR:Q9CCM7 (EMBL:AL583919) (340 aa) fasta scores: E(): 5.2e-46, 43.42% id in 350 aa; hypothetical protein 706434 2649312 DIP0730 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939103.1 705382 D 257309 CDS NP_939104.1 38233337 2649313 complement(706446..707147) 1 NC_002935.2 hypothetical protein 707147 2649313 DIP0731 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939104.1 706446 R 257309 CDS NP_939105.1 38233338 2649314 complement(707195..707698) 1 NC_002935.2 hypothetical protein 707698 2649314 DIP0732 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939105.1 707195 R 257309 CDS NP_939106.1 38233339 2649315 707871..710834 1 NC_002935.2 Similar to Mycobacterium tuberculosis integral membrane protein Rv3193c or MTV014.37c TR:O53339 (EMBL:AL021646) (992 aa) fasta scores: E(): 1e-154, 46.03% id in 1008 aa; hypothetical protein 710834 2649315 DIP0733 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939106.1 707871 D 257309 CDS NP_939107.1 38233340 2649317 complement(711318..711887) 1 NC_002935.2 hypothetical protein 711887 2649317 DIP0734 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939107.1 711318 R 257309 CDS NP_939108.1 38233341 2649318 complement(711917..712231) 1 NC_002935.2 hypothetical protein 712231 2649318 DIP0735 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939108.1 711917 R 257309 CDS NP_939109.1 38233342 2649319 complement(712417..713427) 1 NC_002935.2 C-terminal region similar to Drosophila erecta trypsin zeta precursor Try-ZetA SW:TRYZ_DROER (P54630) (281 aa) fasta scores: E(): 0.17, 26.03% id in 242 aa; protease 713427 2649319 DIP0736 Corynebacterium diphtheriae NCTC 13129 protease NP_939109.1 712417 R 257309 CDS NP_939110.1 38233343 2649320 complement(713430..714386) 1 NC_002935.2 hypothetical protein 714386 2649320 DIP0737 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939110.1 713430 R 257309 CDS NP_939111.1 38233344 2649321 714642..714809 1 NC_002935.2 Doubtful CDS. No significant database matches; hypothetical protein 714809 2649321 DIP0738 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939111.1 714642 D 257309 CDS NP_939112.1 38233345 2649322 715065..716546 1 NC_002935.2 Converts oxaloacetate to phosphoenolpyruvate using ATP as an energy source; oxaloacetate decarboxylase 716546 pycB 2649322 pycB Corynebacterium diphtheriae NCTC 13129 oxaloacetate decarboxylase NP_939112.1 715065 D 257309 CDS NP_939113.1 38233346 2649323 716559..718115 1 NC_002935.2 Similar to Propionigenium modestum methylmalonyl-CoA decarboxylase, alpha-subunit MmdA TR:O54028 (EMBL:AJ002015) (512 aa) fasta scores: E(): 2.2e-105, 54.1% id in 512 aa, and to Bacillus subtilis propionyl-CoA carboxylase beta chain YqjD SW:PCCB_BACSU (P54541) (506 aa) fasta scores: E(): 9.2e-91, 50.1% id in 497 aa; methylcrotonoyl-CoA carboxylase subunit alpha 718115 mmdA 2649323 mmdA Corynebacterium diphtheriae NCTC 13129 methylcrotonoyl-CoA carboxylase subunit alpha NP_939113.1 716559 D 257309 CDS NP_939114.1 38233347 2649324 718129..718392 1 NC_002935.2 hypothetical protein 718392 2649324 DIP0741 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939114.1 718129 D 257309 CDS NP_939115.1 38233348 2650544 718417..718785 1 NC_002935.2 Similar to Propionibacterium freudenreichii shermanii biotin carboxyl carrier protein of methylmalonyl-CoA carboxyl- transferase SW:BCCP_PROFR (P02904) (123 aa) fasta scores: E(): 2.6e-15, 49.18% id in 122 aa; decarboxylase 718785 2650544 DIP0742 Corynebacterium diphtheriae NCTC 13129 decarboxylase NP_939115.1 718417 D 257309 CDS NP_939116.1 38233349 2650545 718856..720079 1 NC_002935.2 hypothetical protein 720079 2650545 DIP0743 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939116.1 718856 D 257309 CDS NP_939117.1 38233350 2650546 complement(720098..720886) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 27.7 kDa protein Rv3137 or MTCY03A2.21c TR:P95189 (EMBL:Z83867) (260 aa) fasta scores: E(): 1.4e-65, 63.42% id in 257 aa; hypothetical protein 720886 2650546 DIP0744 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939117.1 720098 R 257309 CDS NP_939118.1 38233351 2650547 complement(720943..721815) 1 NC_002935.2 Similar to Rhizobium loti myo-inositol-1-monophosphotase MLR4874 TR:Q98D39 (EMBL:AP003005) (264 aa) fasta scores: E(): 1.9e-18, 32.92% id in 243 aa, and to Streptomyces spectabilis myo-inositol-1-monophosphotase SpcA TR:Q9L630 (EMBL:AF244574) (265 aa) fasta scores: E(): 3.8e-14, 31.59% id in 269 aa; hypothetical protein 721815 2650547 DIP0745 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939118.1 720943 R 257309 CDS NP_939119.1 38233352 2650548 721938..723047 1 NC_002935.2 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 723047 prfB 2650548 prfB Corynebacterium diphtheriae NCTC 13129 peptide chain release factor 2 NP_939119.1 721938 D 257309 CDS NP_939120.1 38233353 2650549 complement(723044..724642) 1 NC_002935.2 Similar to Neisseria gonorrhoeae efflux pump component MtrF TR:Q9RNX1 (EMBL:AF176821) (522 aa) fasta scores: E(): 2.4e-35, 40.03% id in 527 aa, and to Escherichia coli aminobenzoyl-glutamate transport protein AbgT or B1336 SW:ABGT_ECOLI (P46133) (510 aa) fasta scores: E(): 1.7e-28, 34.72% id in 527 aa; hypothetical protein 724642 2650549 DIP0747 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939120.1 723044 R 257309 CDS NP_939121.1 38233354 2650550 724821..725510 1 NC_002935.2 Similar to Streptomyces coelicolor cell division ATP-binding protein FtsE TR:Q9L1S6 (EMBL:AL138851) (229 aa) fasta scores: E(): 2.6e-43, 61.06% id in 226 aa, and to Escherichia coli cell division ATP-binding protein FtsE or B3463 or Z4837 or ECS4312 SW:FTSE_ECOLI (P10115) (222 aa) fasta scores: E(): 5.9e-26, 43.36% id in 226 aa; cell division ATP-binding protein 725510 ftsE 2650550 ftsE Corynebacterium diphtheriae NCTC 13129 cell division ATP-binding protein NP_939121.1 724821 D 257309 CDS NP_939122.1 38233355 2650551 725527..726429 1 NC_002935.2 Similar to Mycobacterium leprae cell division protein FtsX homolog or ML0670 or MLCB1779.20c SW:FTSX_MYCLE (O32882) (297 aa) fasta scores: E(): 3.4e-41, 41.19% id in 301 aa, and to Escherichia coli cell division protein FtsX or FtsS or B3462 SW:FTSX_ECOLI (P10122) (352 aa) fasta scores: E(): 3.5e-06, 25% id in 240 aa; cell division protein 726429 2650551 DIP0749 Corynebacterium diphtheriae NCTC 13129 cell division protein NP_939122.1 725527 D 257309 CDS NP_939123.1 38233356 2650552 726536..727027 1 NC_002935.2 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 727027 smpB 2650552 smpB Corynebacterium diphtheriae NCTC 13129 SsrA-binding protein NP_939123.1 726536 D 257309 CDS NP_939124.1 38233357 2650553 727065..727256 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 727256 2650553 DIP0751 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939124.1 727065 D 257309 CDS NP_939125.1 38233358 2649350 727618..728997 1 NC_002935.2 Similar to Escherichia coli possible transposase of IS1353 YahA TR:Q9WTH9 (EMBL:AP000342) (514 aa) fasta scores: E(): 2.6e-62, 41.595% id in 464 aa, and to Escherichia coli transposase InsK for insertion sequence element IS150 or B3558 SW:INSK_ECOLI (P19769) (283 aa) fasta scores: E(): 2.7e-35, 38.628% id in 277 aa; IS element transposase 728997 2649350 DIP0752 Corynebacterium diphtheriae NCTC 13129 IS element transposase NP_939125.1 727618 D 257309 CDS NP_939126.1 38233359 2649351 729107..732040 1 NC_002935.2 Similar to Staphylococcus aureus lantibiotic modifying enzyme TR:Q9S4D1 (EMBL:AF147744) (965 aa) fasta scores: E(): 5.3e-32, 21.471% id in 1006 aa, and to Lactococcus lactis Plasmid pMRC01 lacticin 481/lactococcin biosynthesis protein LcnDR2 TR:O87238 (EMBL:AE001272) (980 aa) fasta scores: E(): 2.6e-16, 21.221% id in 999 aa; lantibiotic modifying enzyme 732040 2649351 DIP0753 Corynebacterium diphtheriae NCTC 13129 lantibiotic modifying enzyme NP_939126.1 729107 D 257309 CDS NP_939127.1 38233360 2649352 732028..734160 1 NC_002935.2 Similar to Staphylococcus aureus transporter TR:Q9S4D0 (EMBL:AF147744) (720 aa) fasta scores: E(): 2.4e-57, 29.986% id in 707 aa, and to Lactococcus lactis cytolysin B transport protein TR:O87239 (EMBL:AE001272) (708 aa) fasta scores: E(): 7.1e-55, 28.571% id in 714 aa; lantibiotic ABC transporter membrane protein 734160 2649352 DIP0754 Corynebacterium diphtheriae NCTC 13129 lantibiotic ABC transporter membrane protein NP_939127.1 732028 D 257309 CDS NP_939128.1 38233361 2649353 734160..735038 1 NC_002935.2 Similar to Bacillus subtilis SpaF TR:Q45404 (EMBL:U09819) (247 aa) fasta scores: E(): 2.2e-22, 42.991% id in 214 aa, and to Corynebacterium jeikeium BlsD TR:AAK94047 (EMBL:AF401314) (301 aa) fasta scores: E(): 2.5e-22, 33.106% id in 293 aa; lantibiotic ABC transporter ATP-binding protein 735038 2649353 DIP0755 Corynebacterium diphtheriae NCTC 13129 lantibiotic ABC transporter ATP-binding protein NP_939128.1 734160 D 257309 CDS NP_939129.1 38233362 2649354 735038..735835 1 NC_002935.2 Similar to Streptomyces coelicolor ABC transporter integral membrane protein SCE8.16c TR:Q9Z4W1 (EMBL:AL035654) (264 aa) fasta scores: E(): 0.0032, 26.695% id in 236 aa, and to Corynebacterium jeikeium BlsC TR:AAK94048 (EMBL:AF401314) (247 aa) fasta scores: E(): 0.81, 21.116% id in 251 aa; lantibiotic ABC transporter membrane protein 735835 2649354 DIP0756 Corynebacterium diphtheriae NCTC 13129 lantibiotic ABC transporter membrane protein NP_939129.1 735038 D 257309 CDS NP_939130.1 38233363 2649355 complement(736001..736267) 1 NC_002935.2 Similar to part of Yersinia enterocolitica IS1222-like transposase TR:Q9X9I1 (EMBL:AJ132945) (165 aa) fasta scores: E(): 5.3e-08, 40.625% id in 64 aa, and of Xanthomonas campestris insertion element IS476 hypothetical 39.2 kDa protein SW:YI61_XANCA (P25438) (346 aa) fasta scores: E(): 3.3e-06, 34.722% id in 72 aa. Also similar to the C-terminal region of DIP0760, transposase (pseudogene) (361 aa) fasta scores: E(): 9.6e-27, 80.000% identity in 70 aa overlap; IS element transposase (partial) 736267 2649355 DIP0757 Corynebacterium diphtheriae NCTC 13129 IS element transposase (partial) NP_939130.1 736001 R 257309 CDS NP_939131.1 38233364 2649356 complement(736323..>736553) 1 NC_002935.2 Similar to part of Salmonella typhimurium LT2 integrase core domain STM2764 TR:AAL21650 (EMBL:AE008826) (155 aa) fasta scores: E(): 0.94, 36.36% id in 44 aa; IS element transposase (partial) >736553 2649356 DIP0757A Corynebacterium diphtheriae NCTC 13129 IS element transposase (partial) NP_939131.1 736323 R 257309 CDS NP_939132.1 38233365 2649357 736810..737148 1 NC_002935.2 Similar to part of Mycobacterium ulcerans probable transposase Tnp TR:Q9ZG97 (EMBL:AF082836) (444 aa) fasta scores: E(): 1.5e-08, 50% id in 82 aa; transposase (partial) 737148 2649357 DIP0758 Corynebacterium diphtheriae NCTC 13129 transposase (partial) NP_939132.1 736810 D 257309 CDS NP_939133.1 38233366 2649359 complement(738682..739023) 1 NC_002935.2 Similar to Methanothermobacter thermautotrophicus hypothetical 11.0 kDa protein MTH1452 TR:O27501 (EMBL:AE000906) (99 aa) fasta scores: E(): 2.8e-10, 41.48% id in 94 aa; hypothetical protein 739023 2649359 DIP0761 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939133.1 738682 R 257309 CDS NP_939134.1 38233367 2649360 complement(739057..739860) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 29.5 kDa protein Rv2622 or MTCY01A10.10c TR:O06190 (EMBL:Z95387) (273 aa) fasta scores: E(): 2.9e-44, 50.96% id in 259 aa; hypothetical protein 739860 2649360 DIP0762 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939134.1 739057 R 257309 CDS NP_939135.1 38233368 2648648 complement(740277..741590) 1 NC_002935.2 Similar to Escherichia coli transposase InsI for insertion sequence element IS30B/C/D (InsI1 or B0256) and (InsI2 or B1404) and (InsI3 or B4284) SW:INSI_ECOLI (P37246) (383 aa) fasta scores: E(): 7.2e-19, 37.94% id in 390 aa; transposase 741590 2648648 DIP0764 Corynebacterium diphtheriae NCTC 13129 transposase NP_939135.1 740277 R 257309 CDS NP_939136.1 38233369 2648649 complement(742372..742674) 1 NC_002935.2 Similar to Corynebacterium jeikeium transposase A TnpA TR:AAK51146 (EMBL:AY033500) (103 aa) fasta scores: E(): 8.1e-16, 56% id in 100 aa; transposase A 742674 tnpA1 2648649 tnpA1 Corynebacterium diphtheriae NCTC 13129 transposase A NP_939136.1 742372 R 257309 CDS NP_939137.1 38233370 2648654 complement(749836..750483) 1 NC_002935.2 hypothetical protein 750483 2648654 DIP0771 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939137.1 749836 R 257309 CDS NP_939138.1 38233371 2648655 complement(750488..752152) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 ATP-dependent DNA helicase, MT0884 TR:AAK45125 (EMBL:AE006976) (542 aa) fasta scores: E(): 1.5e-161, 74.63% id in 544 aa; ATP-dependent DNA helicase 752152 2648655 DIP0772 Corynebacterium diphtheriae NCTC 13129 ATP-dependent DNA helicase NP_939138.1 750488 R 257309 CDS NP_939139.1 38233372 2648656 complement(752198..754516) 1 NC_002935.2 Similar to Mycobacterium leprae possible DNA-binding protein ML2156 TR:Q9CBE1 (EMBL:AL583924) (753 aa) fasta scores: E(): 1.2e-60, 33.5% id in 758 aa; DNA-binding protein 754516 2648656 DIP0773 Corynebacterium diphtheriae NCTC 13129 DNA-binding protein NP_939139.1 752198 R 257309 CDS NP_939140.1 38233373 2648657 754535..754771 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical protein ML2155 TR:Q9CBE2 (EMBL:AL583924) (74 aa) fasta scores: E(): 7.5e-08, 54.09% id in 61 aa; hypothetical protein 754771 2648657 DIP0774 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939140.1 754535 D 257309 CDS NP_939141.1 38233374 2648658 complement(754956..755579) 1 NC_002935.2 Similar to Streptomyces coelicolor secreted protein SCE41.06c TR:Q9F2Q2 (EMBL:AL442120) (244 aa) fasta scores: E(): 5.7e-20, 56.3% id in 119 aa; hypothetical protein 755579 2648658 DIP0775 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939141.1 754956 R 257309 CDS NP_939142.1 38233375 2648659 756260..756649 1 NC_002935.2 Similar to Mycobacterium tuberculosis cold shock protein B CspB or Rv0871 or MTV043.64 TR:O53883 (EMBL:AL022004) (135 aa) fasta scores: E(): 8.9e-24, 52.23% id in 134 aa, and to Streptomyces coelicolor cold shock protein B CspB TR:Q9KXN2 (EMBL:AL357524) (127 aa) fasta scores: E(): 1.8e-19, 48.06% id in 129 aa; cold shock protein B 756649 cspB 2648659 cspB Corynebacterium diphtheriae NCTC 13129 cold shock protein B NP_939142.1 756260 D 257309 CDS NP_939143.1 38233376 2648660 complement(756756..757280) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 17.8 kDa protein Rv0875c precursor or MT0898 or MTCY31.03c SW:Y875_MYCTU (Q10537) (162 aa) fasta scores: E(): 6e-05, 25.92% id in 162 aa; hypothetical protein 757280 2648660 DIP0777 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939143.1 756756 R 257309 CDS NP_939144.1 38233377 2650715 complement(757267..758133) 1 NC_002935.2 Similar to Deinococcus radiodurans glutamine cyclotransferase DR0112 TR:Q9RY39 (EMBL:AE001874) (294 aa) fasta scores: E(): 1e-28, 40.84% id in 284 aa; hypothetical protein 758133 2650715 DIP0778 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939144.1 757267 R 257309 CDS NP_939145.1 38233378 2650806 758173..758937 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical 28.2 kDa protein ML2142 or MLCB57.29 TR:O33058 (EMBL:Z99494) (269 aa) fasta scores: E(): 5.4e-18, 43.55% id in 225 aa; hypothetical protein 758937 2650806 DIP0779 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939145.1 758173 D 257309 CDS NP_939146.1 38233379 2650807 759111..760598 1 NC_002935.2 Similar to Streptomyces coelicolor integral membrane protein SCD12A.17 TR:Q9KXM3 (EMBL:AL357524) (485 aa) fasta scores: E(): 4.6e-64, 46.04% id in 493 aa; hypothetical protein 760598 2650807 DIP0780 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939146.1 759111 D 257309 CDS NP_939147.1 38233380 2650808 760677..761573 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical tRNA/rRNA methyltransferase Rv0881 or MT0904 or MTCY31.09 SW:Y881_MYCTU (Q10543) (288 aa) fasta scores: E(): 2.5e-52, 53.16% id in 284 aa; methyltransferase 761573 2650808 DIP0781 Corynebacterium diphtheriae NCTC 13129 methyltransferase NP_939147.1 760677 D 257309 CDS NP_939148.1 38233381 2650242 complement(761570..762466) 1 NC_002935.2 hypothetical protein 762466 2650242 DIP0782 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939148.1 761570 R 257309 CDS NP_939149.1 38233382 2650243 complement(762487..763536) 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical 27.4 kDa protein ML2137 or MLCB57.36c TR:O33061 (EMBL:Z99494) (251 aa) fasta scores: E(): 1.4e-17, 33.45% id in 284 aa; hypothetical protein 763536 2650243 DIP0783 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939149.1 762487 R 257309 CDS NP_939150.1 38233383 2650244 complement(763738..764868) 1 NC_002935.2 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; phosphoserine aminotransferase 764868 2650244 DIP0784 Corynebacterium diphtheriae NCTC 13129 phosphoserine aminotransferase NP_939150.1 763738 R 257309 CDS NP_939151.2 161598677 2650245 765550..766848 1 NC_002935.2 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 766848 gltA 2650245 gltA Corynebacterium diphtheriae NCTC 13129 type II citrate synthase NP_939151.2 765550 D 257309 CDS NP_939152.1 38233385 2650246 767015..767374 1 NC_002935.2 Similar to Corynebacterium glutamicum probable FK506-binding protein SW:FKBP_CORGL (P42458) (118 aa) fasta scores: E(): 8.4e-38, 82.05% id in 117 aa, and to Escherichia coli FkbP-type peptidyl-prolyl cis-trans isomerase FkpA precursor or B3347 SW:FKBA_ECOLI (P45523) (270 aa) fasta scores: E(): 2.3e-09, 42.71% id in 103 aa; FK506-binding protein 767374 2650246 DIP0786 Corynebacterium diphtheriae NCTC 13129 FK506-binding protein NP_939152.1 767015 D 257309 CDS NP_939153.1 38233386 2650247 complement(767461..768966) 1 NC_002935.2 Similar to Corynebacterium glutamicum carboxyltransferase subunit of acetyl-CoA carboxylase AccDA TR:CAC42827 (EMBL:Y17592) (491 aa) fasta scores: E(): 8.9e-58, 55.31% id in 499 aa, and to Escherichia coli acetyl-coenzyme A carboxylase carboxyl transferase subunit beta AccD or DedB or Usg or B2316 or Z3578 or ECS3200 SW:ACCD_ECOLI (P08193) (304 aa) fasta scores: E(): 8.6e-22, 34.89% id in 235 aa; carboxyltransferase subunit of acetyl-CoA carboxylase 768966 accDA 2650247 accDA Corynebacterium diphtheriae NCTC 13129 carboxyltransferase subunit of acetyl-CoA carboxylase NP_939153.1 767461 R 257309 CDS NP_939154.1 38233387 2650248 769059..769931 1 NC_002935.2 Similar to Streptomyces coelicolor oxidoreductase SC4B5.01c TR:Q9ZBW7 (EMBL:AL034443) (277 aa) fasta scores: E(): 1.3e-48, 48% id in 275 aa, and to Corynebacterium sp 2,5-diketo-D-gluconic acid reductase SW:2DKG_CORSP (P15339) (277 aa) fasta scores: E(): 1.1e-39, 44.52% id in 274 aa; oxidoreductase 769931 2650248 DIP0788 Corynebacterium diphtheriae NCTC 13129 oxidoreductase NP_939154.1 769059 D 257309 CDS NP_939155.1 38233388 2650249 769931..770707 1 NC_002935.2 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 770707 2650249 DIP0789 Corynebacterium diphtheriae NCTC 13129 enoyl-CoA hydratase NP_939155.1 769931 D 257309 CDS NP_939156.1 38233389 2650250 771056..771397 1 NC_002935.2 Similar to Streptomyces coelicolor integral membrane protein SCI8.08c TR:Q9RJ45 (EMBL:AL132644) (124 aa) fasta scores: E(): 2.6e-18, 43.63% id in 110 aa; hypothetical protein 771397 2650250 DIP0790 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939156.1 771056 D 257309 CDS NP_939157.1 38233390 2650251 771401..773053 1 NC_002935.2 Similar to Streptomyces coelicolor transmembrane transport protein SCI8.07c TR:Q9RJ46 (EMBL:AL132644) (544 aa) fasta scores: E(): 4.2e-82, 58.31% id in 547 aa; transport membrane protein 773053 2650251 DIP0791 Corynebacterium diphtheriae NCTC 13129 transport membrane protein NP_939157.1 771401 D 257309 CDS NP_939158.1 38233391 2648627 773178..774032 1 NC_002935.2 hypothetical protein 774032 2648627 DIP0792 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939158.1 773178 D 257309 CDS NP_939159.1 38233392 2648628 complement(774025..774933) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT2601 TR:AAK46909 (EMBL:AE007096) (240 aa) fasta scores: E(): 4.3e-31, 46.31% id in 244 aa. Note: Contains a twin-arginine translocation (TAT) system recognition motif (RRSFLT) at the N-terminal region; hypothetical protein 774933 2648628 DIP0793 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939159.1 774025 R 257309 CDS NP_939160.1 38233393 2648629 complement(775062..776261) 1 NC_002935.2 Similar to Streptomyces coelicolor integral membrane efflux protein SCE39.29 TR:Q9X8F2 (EMBL:AL049573) (404 aa) fasta scores: E(): 7.7e-37, 35.500% id in 400 aa, and to Enterococcus hirae Na(+)/H(+) antiporter NapA SW:NAPA_ENTHR (P26235) (383 aa) fasta scores: E(): 7.5e-12, 21.964% id in 387 aa; Na(+)/H(+) antiporter-like protein 776261 2648629 DIP0794 Corynebacterium diphtheriae NCTC 13129 Na(+)/H(+) antiporter-like protein NP_939160.1 775062 R 257309 CDS NP_939161.1 38233394 2648630 complement(776521..776973) 1 NC_002935.2 hypothetical protein 776973 2648630 DIP0795 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939161.1 776521 R 257309 CDS NP_939162.1 38233395 2648631 complement(776985..777551) 1 NC_002935.2 Similar to bacteriophage bIL311 ORF21 TR:Q9AZG0 (EMBL:AF323672) (306 aa) fasta scores: E(): 0.048, 28.030% id in 132 aa; hypothetical protein 777551 2648631 DIP0796 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939162.1 776985 R 257309 CDS NP_939163.1 38233396 2648632 complement(777583..777750) 1 NC_002935.2 hypothetical protein 777750 2648632 DIP0797 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939163.1 777583 R 257309 CDS NP_939164.1 38233397 2648633 complement(777872..778144) 1 NC_002935.2 hypothetical protein 778144 2648633 DIP0798 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939164.1 777872 R 257309 CDS NP_939165.1 38233398 2648634 778157..778477 1 NC_002935.2 hypothetical protein 778477 2648634 DIP0799 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939165.1 778157 D 257309 CDS NP_939166.1 38233399 2648635 778799..779374 1 NC_002935.2 hypothetical protein 779374 2648635 DIP0800 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939166.1 778799 D 257309 CDS NP_939167.1 38233400 2648636 779748..780104 1 NC_002935.2 hypothetical protein 780104 2648636 DIP0801 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939167.1 779748 D 257309 CDS NP_939168.1 38233401 2648637 complement(780077..780574) 1 NC_002935.2 Similar to bacteriophage bIL311 ORF21 TR:Q9AZG0 (EMBL:AF323672) (306 aa) fasta scores: E(): 0.0075, 25.203% id in 123 aa; hypothetical protein 780574 2648637 DIP0802 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939168.1 780077 R 257309 CDS NP_939169.1 38233402 2648638 complement(780837..781160) 1 NC_002935.2 hypothetical protein 781160 2648638 DIP0803 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939169.1 780837 R 257309 CDS NP_939170.1 38233403 2648639 complement(781172..783724) 1 NC_002935.2 hypothetical protein 783724 2648639 DIP0804 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939170.1 781172 R 257309 CDS NP_939171.1 38233404 2648640 complement(783728..785731) 1 NC_002935.2 Similar to Haemophilus influenzae type III restriction-modification system HinDVIp enzyme Mod HI1056 SW:T3MH_HAEIN (P71366) (629 aa) fasta scores: E(): 8.3e-26, 29.960% id in 504 aa, and to Lactococcus lactis modification methylase LlaFI Mod TR:Q9Z6H7 (EMBL:AF054600) (680 aa) fasta scores: E(): 5.8e-13, 29.369% id in 412 aa; DNA methylase 785731 2648640 DIP0805 Corynebacterium diphtheriae NCTC 13129 DNA methylase NP_939171.1 783728 R 257309 CDS NP_939172.1 38233405 2648641 786230..786958 1 NC_002935.2 Similar to Bacteriophage P1 hypothetical 19.9 kDa protein TR:Q9XJP4 (EMBL:AF137370) (166 aa) fasta scores: E(): 8.2e-09, 28.467% id in 137 aa; hypothetical protein 786958 2648641 DIP0806 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939172.1 786230 D 257309 CDS NP_939173.1 38233406 2648642 786955..787392 1 NC_002935.2 hypothetical protein 787392 2648642 DIP0807 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939173.1 786955 D 257309 CDS NP_939174.1 38233407 2648643 complement(787574..787945) 1 NC_002935.2 hypothetical protein 787945 2648643 DIP0808 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939174.1 787574 R 257309 CDS NP_939175.1 38233408 2648644 complement(787932..788174) 1 NC_002935.2 hypothetical protein 788174 2648644 DIP0809 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939175.1 787932 R 257309 CDS NP_939176.1 38233409 2648645 complement(788227..788601) 1 NC_002935.2 hypothetical protein 788601 2648645 DIP0810 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939176.1 788227 R 257309 CDS NP_939177.1 38233410 2648646 complement(788588..788956) 1 NC_002935.2 hypothetical protein 788956 2648646 DIP0811 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939177.1 788588 R 257309 CDS NP_939178.1 38233411 2648647 complement(788946..789917) 1 NC_002935.2 hypothetical protein 789917 2648647 DIP0812 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939178.1 788946 R 257309 CDS NP_939179.1 38233412 2649989 789916..790419 1 NC_002935.2 hypothetical protein 790419 2649989 DIP0813 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939179.1 789916 D 257309 CDS NP_939180.1 38233413 2649990 790442..790960 1 NC_002935.2 hypothetical protein 790960 2649990 DIP0816 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939180.1 790442 D 257309 CDS NP_939181.1 38233414 2649991 790953..792017 1 NC_002935.2 Similar to Mycobacterium tuberculosis probable integrase/recombinase XerC or Rv2894c or MT2962 or MTCY274.25c SW:XERC_MYCTU (Q10815) (298 aa) fasta scores: E(): 3.7, 24.904% id in 261 aa; phage integrase 792017 2649991 DIP0817 Corynebacterium diphtheriae NCTC 13129 phage integrase NP_939181.1 790953 D 257309 CDS NP_939182.1 38233415 2649992 complement(792350..792688) 1 NC_002935.2 hypothetical protein 792688 2649992 DIP0818 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939182.1 792350 R 257309 CDS NP_939183.1 38233416 2649993 792701..793471 1 NC_002935.2 hypothetical protein 793471 2649993 DIP0819 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939183.1 792701 D 257309 CDS NP_939184.1 38233417 2650534 793522..795300 1 NC_002935.2 hypothetical protein 795300 2650534 DIP0820 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939184.1 793522 D 257309 CDS NP_939185.1 38233418 2650536 795749..796081 1 NC_002935.2 hypothetical protein 796081 2650536 DIP0821 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939185.1 795749 D 257309 CDS NP_939186.1 38233419 2650537 796088..796840 1 NC_002935.2 catalyzes the formation of precorrin 6x from precorrin 5; precorrin 6A synthase 796840 2650537 DIP0822 Corynebacterium diphtheriae NCTC 13129 precorrin 6A synthase NP_939186.1 796088 D 257309 CDS NP_939187.1 38233420 2650538 complement(796859..797116) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3292 TR:AAK47635 (EMBL:AE007142) (84 aa) fasta scores: E(): 4.4e-12, 48.1% id in 79 aa; hypothetical protein 797116 2650538 DIP0823 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939187.1 796859 R 257309 CDS NP_939188.1 38233421 2650539 complement(797137..797640) 1 NC_002935.2 Similar to Mycobacterium avium dihydrofolate reductase FolA TR:O30463 (EMBL:AF006616) (181 aa) fasta scores: E(): 2e-22, 46.1% id in 167 aa, and to Escherichia coli dihydrofolate reductase FolA or TmrA or B0048 SW:DYR_ECOLI (P00379) (159 aa) fasta scores: E(): 1.5e-13, 42.76% id in 152 aa; folate reductase 797640 2650539 DIP0824 Corynebacterium diphtheriae NCTC 13129 folate reductase NP_939188.1 797137 R 257309 CDS NP_939189.1 38233422 2650540 complement(797640..798452) 1 NC_002935.2 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 798452 thyA 2650540 thyA Corynebacterium diphtheriae NCTC 13129 thymidylate synthase NP_939189.1 797640 R 257309 CDS NP_939190.1 38233423 2650541 complement(798546..799304) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CysQ protein homolog or Rv2131c or MT2189 or MTCY270.37 SW:CYSQ_MYCTU (O06244) (267 aa) fasta scores: E(): 9.2e-23, 52.51% id in 259 aa; sulfite synthesis-like protein 799304 2650541 DIP0826 Corynebacterium diphtheriae NCTC 13129 sulfite synthesis-like protein NP_939190.1 798546 R 257309 CDS NP_939191.1 38233424 2650542 799343..804157 1 NC_002935.2 Similar to Escherichia coli probable ATP-dependent helicase Lhr or RhlF or B1653 SW:LHR_ECOLI (P30015) (1538 aa) fasta scores: E(): 1.4e-134, 46.42% id in 1579 aa; ATP-dependent helicase 804157 2650542 DIP0827 Corynebacterium diphtheriae NCTC 13129 ATP-dependent helicase NP_939191.1 799343 D 257309 CDS NP_939192.1 38233425 2650543 complement(804154..804705) 1 NC_002935.2 Similar to Streptomyces coelicolor G/U mismatch-specific DNA glycosylase Mug TR:Q9K3I5 (EMBL:AL390188) (160 aa) fasta scores: E(): 1.6e-21, 46.49% id in 157 aa, and to Escherichia coli G/U mismatch-specific DNA glycosylase Mug or B3068 SW:MUG_ECOLI (P43342) (168 aa) fasta scores: E(): 1.1e-15, 36.84% id in 171 aa; DNA repair protein 804705 2650543 DIP0828 Corynebacterium diphtheriae NCTC 13129 DNA repair protein NP_939192.1 804154 R 257309 CDS NP_939193.1 38233426 2649291 804836..805642 1 NC_002935.2 Similar to Streptomyces coelicolor endonuclease VIII Nei or SC7C7.15c SW:END8_STRCO (O86820) (276 aa) fasta scores: E(): 2.5e-39, 40.87% id in 274 aa, and to Escherichia coli endonuclease VIII Nei or B0714 SW:END8_ECOLI (P50465) (262 aa) fasta scores: E(): 4.6e-14, 28.88% id in 277 aa; endonuclease 805642 2649291 DIP0829 Corynebacterium diphtheriae NCTC 13129 endonuclease NP_939193.1 804836 D 257309 CDS NP_939194.1 38233427 2649292 complement(805625..807250) 1 NC_002935.2 Similar to Escherichia coli hypothetical 58.9 kDa protein YidE or B3685 SW:YIDE_ECOLI (P29211) (553 aa) fasta scores: E(): 1.8e-44, 33.21% id in 554 aa; hypothetical protein 807250 2649292 DIP0830 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939194.1 805625 R 257309 CDS NP_939195.1 38233428 2649293 807364..807777 1 NC_002935.2 Similar to Streptomyces coelicolor integral membrane protein SCD39.10 TR:Q9F2V1 (EMBL:AL392146) (138 aa) fasta scores: E(): 8.5e-26, 54.26% id in 129 aa; hypothetical protein 807777 2649293 DIP0831 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939195.1 807364 D 257309 CDS NP_939196.1 38233429 2649294 complement(807862..809505) 1 NC_002935.2 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 809505 pgi 2649294 pgi Corynebacterium diphtheriae NCTC 13129 glucose-6-phosphate isomerase NP_939196.1 807862 R 257309 CDS NP_939197.1 38233430 2649295 809708..811192 1 NC_002935.2 Similar to Escherichia coli succinate-semialdehyde dehydrogenase [NADP+] GabD or B2661 SW:GABD_ECOLI (P25526) (482 aa) fasta scores: E(): 2.9e-76, 44.37% id in 471 aa; succinate-semialdehyde dehydrogenase 811192 2649295 DIP0833 Corynebacterium diphtheriae NCTC 13129 succinate-semialdehyde dehydrogenase NP_939197.1 809708 D 257309 CDS NP_939198.1 38233431 2649296 complement(811189..811521) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 11.8 kDa protein Rv0948c or MT0975 or MTCY10D7.26 SW:Y948_MYCTU (P71562) (105 aa) fasta scores: E(): 1.6e-14, 62.35% id in 85 aa; hypothetical protein 811521 2649296 DIP0834 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939198.1 811189 R 257309 CDS NP_939199.1 38233432 2649297 811671..814088 1 NC_002935.2 Similar to Mycobacterium leprae ATP-dependent DNA helicase PcrA or UvrD or ML0153 SW:PCRA_MYCLE (Q9CD72) (778 aa) fasta scores: E(): 5.7e-165, 59.08% id in 804 aa, and to Bacillus subtilis ATP-dependent DNA helicase PcrA SW:PCRA_BACSU (O34580) (739 aa) fasta scores: E(): 4.1e-80, 42.76% id in 802 aa; ATP-dependent DNA helicase 814088 pcrA 2649297 pcrA Corynebacterium diphtheriae NCTC 13129 ATP-dependent DNA helicase NP_939199.1 811671 D 257309 CDS NP_939200.1 38233433 2649298 complement(814166..814882) 1 NC_002935.2 Similar to C-terminal region of Mycobacterium tuberculosis CDC1551 peptidase, M23/M37 family MT0977 TR:AAK45225 (EMBL:AE006983) (332 aa) fasta scores: E(): 2.2e-33, 45.25% id in 232 aa; hypothetical protein 814882 2649298 DIP0836 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939200.1 814166 R 257309 CDS NP_939201.1 38233434 2649299 815288..816742 1 NC_002935.2 Low similarity to Mycobacterium tuberculosis hypothetical 46.1 kDa protein Rv0955 or MT0982 or MTCY10D7.19c SW:Y955_MYCTU (P71555) (455 aa) fasta scores: E(): 1.9e-17, 28.01% id in 439 aa; hypothetical protein 816742 2649299 DIP0837 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939201.1 815288 D 257309 CDS NP_939202.1 38233435 2649300 816768..817391 1 NC_002935.2 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 817391 purN 2649300 purN Corynebacterium diphtheriae NCTC 13129 phosphoribosylglycinamide formyltransferase NP_939202.1 816768 D 257309 CDS NP_939203.1 38233436 2649301 817381..818958 1 NC_002935.2 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 818958 purH 2649301 purH Corynebacterium diphtheriae NCTC 13129 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase NP_939203.1 817381 D 257309 CDS NP_939204.1 38233437 2649302 819223..819702 1 NC_002935.2 No significant database matches. Similar to CDS downstream DIP0841 38.272% identity in 162 aa overlap; hypothetical protein 819702 2649302 DIP0840 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939204.1 819223 D 257309 CDS NP_939205.1 38233438 2649303 819871..820371 1 NC_002935.2 No significant database matches. Similar to CDS upstream DIP0840 38.272% identity in 162 aa overlap; hypothetical protein 820371 2649303 DIP0841 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939205.1 819871 D 257309 CDS NP_939206.1 38233439 2649304 820408..820974 1 NC_002935.2 hypothetical protein 820974 2649304 DIP0842 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939206.1 820408 D 257309 CDS NP_939207.1 38233440 2649305 complement(820987..822363) 1 NC_002935.2 Similar to Escherichia coli possible transposase of IS1353 YahA SWALL:Q9WTH9 (EMBL:AP000342) (514 aa) fasta scores: E(): 8.7e-62, 41.25% id in 463 aa; transposase 822363 2649305 DIP0843 Corynebacterium diphtheriae NCTC 13129 transposase NP_939207.1 820987 R 257309 CDS NP_939208.1 38233441 2649306 822365..822775 1 NC_002935.2 hypothetical protein 822775 2649306 DIP0844 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939208.1 822365 D 257309 CDS NP_939209.1 38233442 2649307 822822..823655 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 citrate lyase, beta subunit MT2573 TR:AAK46877 (EMBL:AE007094) (273 aa) fasta scores: E(): 9.7e-35, 42.42% id in 264 aa, and to Escherichia coli citrate lyase beta chain CitE or B0616 SW:CILB_ECOLI (P77770) (302 aa) fasta scores: E(): 1.8e-06, 25.83% id in 298 aa; citrate lyase 823655 2649307 DIP0845 Corynebacterium diphtheriae NCTC 13129 citrate lyase NP_939209.1 822822 D 257309 CDS NP_939210.1 38233443 2649308 complement(823652..824320) 1 NC_002935.2 Similar to Corynebacterium glutamicum AmtR protein TR:Q9S3L4 (EMBL:AJ133719) (222 aa) fasta scores: E(): 9.6e-59, 70.18% id in 218 aa; TetR family regulatory protein 824320 amtR 2649308 amtR Corynebacterium diphtheriae NCTC 13129 TetR family regulatory protein NP_939210.1 823652 R 257309 CDS NP_939211.1 38233444 2649640 complement(824445..825479) 1 NC_002935.2 hypothetical protein 825479 2649640 DIP0847 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939211.1 824445 R 257309 CDS NP_939212.1 38233445 2649641 complement(825552..825800) 1 NC_002935.2 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 825800 rpsR 2649641 rpsR Corynebacterium diphtheriae NCTC 13129 30S ribosomal protein S18 NP_939212.1 825552 R 257309 CDS NP_939213.1 38233446 2649642 complement(825815..826120) 1 NC_002935.2 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 826120 rpsN 2649642 rpsN Corynebacterium diphtheriae NCTC 13129 30S ribosomal protein S14 NP_939213.1 825815 R 257309 CDS NP_939214.1 38233447 2649643 complement(826124..826288) 1 NC_002935.2 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 826288 rpmG 2649643 rpmG Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L33 NP_939214.1 826124 R 257309 CDS NP_939215.1 38233448 2649644 complement(826292..826528) 1 NC_002935.2 required for 70S ribosome assembly; 50S ribosomal protein L28 826528 rpmB 2649644 rpmB Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L28 NP_939215.1 826292 R 257309 CDS NP_939216.1 38233449 2649645 826998..827264 1 NC_002935.2 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 827264 rpmE2 2649645 rpmE2 Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L31 NP_939216.1 826998 D 257309 CDS NP_939217.1 38233450 2649646 827283..827456 1 NC_002935.2 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 827456 rpmF 2649646 rpmF Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L32 NP_939217.1 827283 D 257309 CDS NP_939218.1 38233451 2649647 827685..828377 1 NC_002935.2 Similar to Corynebacterium glutamicum response regulator TR:Q9F161 (EMBL:AF119221) (232 aa) fasta scores: E(): 2.4e-67, 79.31% id in 232 aa, and to Pseudomonas syringae transcriptional activator protein CopR SW:COPR_PSESM (Q02540) (227 aa) fasta scores: E(): 1.9e-32, 48% id in 225 aa; two component system response regulator 828377 2649647 DIP0854 Corynebacterium diphtheriae NCTC 13129 two component system response regulator NP_939218.1 827685 D 257309 CDS NP_939219.1 38233452 2649648 828428..829918 1 NC_002935.2 Similar to Corynebacterium glutamicum sensor kinase TR:Q9F160 (EMBL:AF119221) (455 aa) fasta scores: E(): 6.5e-71, 46.98% id in 447 aa, and to Burkholderia pseudomallei sensor protein IrlS SW:IRLS_BURPS (O31396) (464 aa) fasta scores: E(): 4.6e-18, 26% id in 446 aa; two component system sensor kinase 829918 2649648 DIP0855 Corynebacterium diphtheriae NCTC 13129 two component system sensor kinase NP_939219.1 828428 D 257309 CDS NP_939220.1 38233453 2649649 830008..831294 1 NC_002935.2 Similar to Mycobacterium tuberculosis serine protease Rv0983 or MTV044.11 SWALL:O53896 (EMBL:AL021999) (464 aa) fasta scores: E(): 3.8e-46, 43.84% id in 406 aa, and to Brucella abortus probable serine protease do-like precursor DegP or HtrA SWALL:DEGP_BRUAB (SWALL:Q44597) (513 aa) fasta scores: E(): 7.6e-25, 44.56% id in 285 aa; serine protease 831294 2649649 DIP0856 Corynebacterium diphtheriae NCTC 13129 serine protease NP_939220.1 830008 D 257309 CDS NP_939221.1 38233454 2649650 831333..831920 1 NC_002935.2 Similar to Mycobacterium leprae molybdenum cofactor biosynthesis protein MoaB or ML0177 or MLCB373.29 TR:Q9Z5G5 (EMBL:AL035500) (181 aa) fasta scores: E(): 8.3e-28, 60% id in 150 aa; molybdopterin biosynthesis protein 831920 2649650 DIP0857 Corynebacterium diphtheriae NCTC 13129 molybdopterin biosynthesis protein NP_939221.1 831333 D 257309 CDS NP_939222.1 38233455 2648534 831950..832135 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 832135 2648534 DIP0858 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939222.1 831950 D 257309 CDS NP_939223.1 38233456 2648535 complement(832222..832626) 1 NC_002935.2 Similar to Mycobacterium tuberculosis large-conductance mechanosensitive channel MscL or Rv0985c or MT1013 or MTV044.13c SW:MSCL_MYCTU (O53898) (151 aa) fasta scores: E(): 3e-16, 48.5% id in 134 aa, and to Escherichia coli, and large-conductance mechanosensitive channel MscL or B3291 or Z4661 or ECS4156 SW:MSCL_ECOLI (P23867) (136 aa) fasta scores: E(): 9.2e-11, 41.3% id in 138 aa; large-conductance mechanosensitive channel 832626 mscL 2648535 mscL Corynebacterium diphtheriae NCTC 13129 large-conductance mechanosensitive channel NP_939223.1 832222 R 257309 CDS NP_939224.1 38233457 2648536 complement(832733..833416) 1 NC_002935.2 hypothetical protein 833416 2648536 DIP0860 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939224.1 832733 R 257309 CDS NP_939225.1 38233458 2648537 complement(833432..834016) 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical 21.3 kDa protein ML0181 or MLCB373.33c TR:Q9Z5G2 (EMBL:AL035500) (197 aa) fasta scores: E(): 2.1e-14, 34.73% id in 190 aa; hypothetical protein 834016 2648537 DIP0861 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939225.1 833432 R 257309 CDS NP_939226.1 38233459 2648538 834145..835065 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 UTP--glucose-1-phosphate uridylyltransferase MT1022 TR:AAK45269 (EMBL:AE006986) (306 aa) fasta scores: E(): 3.2e-65, 64.8% id in 287 aa, and to Bacillus subtilis UTP--glucose-1-phosphate uridylyltransferase GtaB SW:GTAB_BACSU (Q05852) (292 aa) fasta scores: E(): 1.4e-32, 40.67% id in 295 aa; urydyltransferase 835065 2648538 DIP0862 Corynebacterium diphtheriae NCTC 13129 urydyltransferase NP_939226.1 834145 D 257309 CDS NP_939227.1 38233460 2648539 835162..836427 1 NC_002935.2 Similar to Mycobacterium tuberculosis molybdopterin biosynthesis protein MoeA or Rv0994 or MT1023 or MTCI237.08 SW:MOEA_MYCTU (O05577) (426 aa) fasta scores: E(): 1.1e-89, 58.35% id in 425 aa, and to Escherichia coli molybdopterin biosynthesis protein MoeA or ChlE or BisB or NarE or B0827 SW:MOEA_ECOLI (P12281) (411 aa) fasta scores: E(): 1.1e-17, 29.58% id in 409 aa; molybdopterin biosynthesis protein 836427 2648539 DIP0863 Corynebacterium diphtheriae NCTC 13129 molybdopterin biosynthesis protein NP_939227.1 835162 D 257309 CDS NP_939228.1 38233461 2648540 836463..837125 1 NC_002935.2 Similar to Mycobacterium leprae possible acetyltransferase RimJ or ML0184 TR:Q9CD65 (EMBL:AL583917) (214 aa) fasta scores: E(): 3.6e-35, 47.03% id in 202 aa; acetyltransferase 837125 2648540 DIP0864 Corynebacterium diphtheriae NCTC 13129 acetyltransferase NP_939228.1 836463 D 257309 CDS NP_939229.1 38233462 2648541 837252..838388 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 39.5 kDa protein Rv0996 or MTCI237.10 TR:O05579 (EMBL:Z94752) (358 aa) fasta scores: E(): 1.8e-13, 30.27% id in 370 aa; hypothetical protein 838388 2648541 DIP0865 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939229.1 837252 D 257309 CDS NP_939230.1 38233463 2648542 838431..838844 1 NC_002935.2 Similar to Mycobacterium leprae integral membrane protein ML0956 TR:Q9CCC8 (EMBL:AL583920) (169 aa) fasta scores: E(): 2.1e-11, 39.51% id in 124 aa; hypothetical protein 838844 2648542 DIP0866 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939230.1 838431 D 257309 CDS NP_939231.1 38233464 2648543 838831..839493 1 NC_002935.2 hypothetical protein 839493 2648543 DIP0867 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939231.1 838831 D 257309 CDS NP_939232.1 38233465 2648544 complement(839502..841211) 1 NC_002935.2 Similar to Mycobacterium leprae membrane protein ML0192 TR:Q9CD61 (EMBL:AL583917) (510 aa) fasta scores: E(): 8e-80, 42.74% id in 496 aa; hypothetical protein 841211 2648544 DIP0868 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939232.1 839502 R 257309 CDS NP_939233.1 38233466 2648545 841745..843490 1 NC_002935.2 Similar to Corynebacterium glutamicum glycine betaine transporter BetP SW:BETP_CORGL (P54582) (595 aa) fasta scores: E(): 7.8e-154, 70.87% id in 563 aa, and to Bacillus subtilis glycine betaine transporter OpuD SW:OPUD_BACSU (P54417) (512 aa) fasta scores: E(): 1.1e-76, 43.52% id in 517 aa; glycine betaine transporter 843490 betP 2648545 betP Corynebacterium diphtheriae NCTC 13129 glycine betaine transporter NP_939233.1 841745 D 257309 CDS NP_939234.1 38233467 2648546 843569..845032 1 NC_002935.2 Similar to Staphylococcus aureus (strain N315) hypothetical protein SA2305 or SAV2517 TR:BAB58679 (EMBL:AP003137) (359 aa) fasta scores: E(): 1.3e-35, 32.55% id in 344 aa; hypothetical protein 845032 2648546 DIP0870 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939234.1 843569 D 257309 CDS NP_939235.1 38233468 2648547 845142..846017 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 29.7 kDa protein Rv1003 or MT1032 or MTCI237.19 SW:YA03_MYCTU (O05588) (285 aa) fasta scores: E(): 2.1e-51, 58.54% id in 275 aa; hypothetical protein 846017 2648547 DIP0871 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939235.1 845142 D 257309 CDS NP_939236.1 38233469 2648486 846041..847873 1 NC_002935.2 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 847873 metG 2648486 metG Corynebacterium diphtheriae NCTC 13129 methionyl-tRNA synthetase NP_939236.1 846041 D 257309 CDS NP_939237.1 38233470 2648487 847895..848749 1 NC_002935.2 Similar to Corynebacterium glutamicum Mg-dependent DNAse CGL0908 SWALL:Q8NRY3 (EMBL:AP005276) (277 aa) fasta scores: E(): 3.7e-81, 73.74% id in 278 aa, and to Mycobacterium tuberculosis hypothetical protein Ycfh Rv1008 or MTCI237.25 TR:O08343 (EMBL:Z94752) (264 aa) fasta scores: E(): 4.4e-40, 44.61% id in 260 aa; hypothetical protein 848749 2648487 DIP0873 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939237.1 847895 D 257309 CDS NP_939238.1 38233471 2648488 848894..850051 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 38.1 kDa protein Rv1009 or MTCI237.26 TR:O05594 (EMBL:Z94752) (362 aa) fasta scores: E(): 1.8e-39, 38.71% id in 372 aa; hypothetical protein 850051 2648488 DIP0874 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939238.1 848894 D 257309 CDS NP_939239.1 38233472 2648489 850103..850990 1 NC_002935.2 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 850990 ksgA 2648489 ksgA Corynebacterium diphtheriae NCTC 13129 dimethyladenosine transferase NP_939239.1 850103 D 257309 CDS NP_939240.1 38233473 2648490 850987..851922 1 NC_002935.2 catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 851922 2648490 DIP0876 Corynebacterium diphtheriae NCTC 13129 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase NP_939240.1 850987 D 257309 CDS NP_939241.1 38233474 2648491 851922..853730 1 NC_002935.2 Similar to Streptomyces coelicolor ABC transporter ATP-binding subunit SCE66.26c TR:Q9K3R7 (EMBL:AL359989) (604 aa) fasta scores: E(): 2.3e-97, 54.75% id in 610 aa; ABC transporter ATP-binding protein 853730 2648491 DIP0877 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_939241.1 851922 D 257309 CDS NP_939242.1 38233475 2648492 853749..854072 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 12.0 kDa protein Rv1117 or MTCY22G8.06 TR:O06569 (EMBL:Z95585) (107 aa) fasta scores: E(): 3.6e-13, 43.92% id in 107 aa; hypothetical protein 854072 2648492 DIP0878 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939242.1 853749 D 257309 CDS NP_939243.1 38233476 2648493 854176..854565 1 NC_002935.2 hypothetical protein 854565 2648493 DIP0879 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939243.1 854176 D 257309 CDS NP_939244.1 38233477 2648494 854590..855129 1 NC_002935.2 Similar to Xanthomonas campestris probable RNA polymerase sigma factor RfaY SW:RFAY_XANCP (P46358) (217 aa) fasta scores: E(): 9.8e-07, 32.88% id in 149 aa; RNA polymerase ECF-subfamily sigma factor 855129 2648494 DIP0880 Corynebacterium diphtheriae NCTC 13129 RNA polymerase ECF-subfamily sigma factor NP_939244.1 854590 D 257309 CDS NP_939245.1 38233478 2648495 855138..856313 1 NC_002935.2 hypothetical protein 856313 2648495 DIP0881 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939245.1 855138 D 257309 CDS NP_939246.1 38233479 2648496 856347..857252 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 RNA polymerase sigma factor, MT3329 TR:AAK47672 (EMBL:AE007144) (295 aa) fasta scores: E(): 1.4e-68, 61.42% id in 280 aa, and to Pseudomonas aeruginosa pao substrain OT684 pyoverdine gene transcriptional regulator PvdS TR:P72119 (EMBL:U12891) (237 aa) fasta scores: E(): 5.9e-56, 59.91% id in 237 aa; RNA polymerase sigma factor 857252 2648496 DIP0882 Corynebacterium diphtheriae NCTC 13129 RNA polymerase sigma factor NP_939246.1 856347 D 257309 CDS NP_939247.1 38233480 2648497 complement(857329..858042) 1 NC_002935.2 Low similarity to Escherichia coli protein PnuC or B0751 SW:PNUC_ECOLI (P31215) (239 aa) fasta scores: E(): 5e-07, 23.75% id in 240 aa; hypothetical protein 858042 2648497 DIP0883 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939247.1 857329 R 257309 CDS NP_939248.1 38233481 2648498 complement(858062..858862) 1 NC_002935.2 Similar to Streptococcus pyogenes hypothetical protein SPY0567 TR:Q9A0X9 (EMBL:AE006513) (265 aa) fasta scores: E(): 6.5e-20, 32.31% id in 263 aa; hypothetical protein 858862 2648498 DIP0884 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939248.1 858062 R 257309 CDS NP_939249.1 38233482 2648499 858962..860014 1 NC_002935.2 catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA; 3-hydroxyisobutyryl-CoA hydrolase 860014 2648499 DIP0885 Corynebacterium diphtheriae NCTC 13129 3-hydroxyisobutyryl-CoA hydrolase NP_939249.1 858962 D 257309 CDS NP_939250.1 38233483 2648500 complement(860011..861270) 1 NC_002935.2 hypothetical protein 861270 2648500 DIP0886 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939250.1 860011 R 257309 CDS NP_939251.1 38233484 2648501 complement(861306..861530) 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 861530 2648501 DIP0887 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939251.1 861306 R 257309 CDS NP_939252.1 38233485 2648502 complement(861538..861912) 1 NC_002935.2 Similar to Streptomyces coelicolor tetR-family transcriptional regulator SCF56.06 TR:Q9RD60 (EMBL:AL133424) (213 aa) fasta scores: E(): 2.9e-07, 40.51% id in 116 aa; TetR family transcriptional regulatory protein (partial) 861912 2648502 DIP0888 Corynebacterium diphtheriae NCTC 13129 TetR family transcriptional regulatory protein (partial) NP_939252.1 861538 R 257309 CDS NP_939253.1 38233486 2648503 complement(862009..862128) 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 862128 2648503 DIP0889 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939253.1 862009 R 257309 CDS NP_939254.1 38233487 2648504 complement(862236..862532) 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 862532 2648504 DIP0890 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939254.1 862236 R 257309 CDS NP_939255.1 38233488 2648505 complement(862908..864338) 1 NC_002935.2 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; involved in growth under gluconeogenic conditions and in glycolytic activity at high ATP concentrations in Corynebacterium; NAD and NADP dependent; glyceraldehyde-3-phosphate dehydrogenase 864338 2648505 DIP0892 Corynebacterium diphtheriae NCTC 13129 glyceraldehyde-3-phosphate dehydrogenase NP_939255.1 862908 R 257309 CDS NP_939256.1 38233489 2648577 864602..865255 1 NC_002935.2 hypothetical protein 865255 2648577 DIP0893 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939256.1 864602 D 257309 CDS NP_939257.1 38233490 2648578 865283..865486 1 NC_002935.2 Low similarity to Arabidopsis thaliana AT2G37870 protein or T8P21.22 TR:Q9SHA0 (EMBL:AC007661) (115 aa) fasta scores: E(): 6.8, 31.66% id in 60 aa; hypothetical protein 865486 2648578 DIP0894 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939257.1 865283 D 257309 CDS NP_939258.1 38233491 2648579 complement(865500..867134) 1 NC_002935.2 Similar to Caulobacter crescentus peptide chain release factor 3 CC1070 TR:Q9A9B9 (EMBL:AE005784) (534 aa) fasta scores: E(): 2.4e-70, 40% id in 545 aa, and to Staphylococcus aureus peptide chain release factor 3 PrfC or Rf3 SW:RF3_STAAU (O86490) (521 aa) fasta scores: E(): 2e-38, 38.57% id in 547 aa, and to Escherichia coli peptide chain release factor 3 PrfC or Tos or MiaD or B4375 or Z5976 or ECS5333 SW:RF3_ECOLI (P33998) (528 aa) fasta scores: E(): 1.6e-24, 41.94% id in 534 aa; peptide chain release factor 3 867134 2648579 DIP0895 Corynebacterium diphtheriae NCTC 13129 peptide chain release factor 3 NP_939258.1 865500 R 257309 CDS NP_939259.1 38233492 2648580 complement(867146..867955) 1 NC_002935.2 Similar to Streptomyces peucetius daunorubicin C-13 ketoreductase DnrU TR:Q9ZAU1 (EMBL:U77891) (287 aa) fasta scores: E(): 1.3e-16, 35.25% id in 278 aa; oxidoreductase 867955 2648580 DIP0896 Corynebacterium diphtheriae NCTC 13129 oxidoreductase NP_939259.1 867146 R 257309 CDS NP_939260.1 38233493 2648581 complement(867987..868529) 1 NC_002935.2 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 868529 2648581 DIP0897 Corynebacterium diphtheriae NCTC 13129 peptidyl-tRNA hydrolase NP_939260.1 867987 R 257309 CDS NP_939261.1 38233494 2648582 868809..869369 1 NC_002935.2 hypothetical protein 869369 2648582 DIP0898 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939261.1 868809 D 257309 CDS NP_939262.1 38233495 2648583 869457..869972 1 NC_002935.2 Low similarity to parts of Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT0103 TR:AAK44326 (EMBL:AE006921) (287 aa) fasta scores: E(): 5.6e-09, 39.04% id in 105 aa; hypothetical protein 869972 2648583 DIP0899 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939262.1 869457 D 257309 CDS NP_939263.1 38233496 2648584 complement(870146..870700) 1 NC_002935.2 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 870700 2648584 DIP0900 Corynebacterium diphtheriae NCTC 13129 peptidyl-tRNA hydrolase NP_939263.1 870146 R 257309 CDS NP_939264.1 38233497 2648585 complement(870759..871376) 1 NC_002935.2 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 871376 2648585 DIP0901 Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L25 NP_939264.1 870759 R 257309 CDS NP_939265.1 38233498 2648586 complement(871597..873411) 1 NC_002935.2 Similar to the C-terminal regions of Thermotoga maritima pullulanase precursor PulA or TM1845 SW:PULA_THEMA (O33840) (843 aa) fasta scores: E(): 3.3e-67, 36.72% id in 610 aa, and of Klebsiella pneumoniae pullulanase precursor PulA SW:PULA_KLEPN (P07206) (1090 aa) fasta scores: E(): 1.2e-20, 28.94% id in 615 aa; hydrolase 873411 2648586 DIP0902 Corynebacterium diphtheriae NCTC 13129 hydrolase NP_939265.1 871597 R 257309 CDS NP_939266.1 38233499 2648587 complement(873535..874515) 1 NC_002935.2 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 874515 prsA 2648587 prsA Corynebacterium diphtheriae NCTC 13129 ribose-phosphate pyrophosphokinase NP_939266.1 873535 R 257309 CDS NP_939267.1 38233500 2648588 complement(874524..875978) 1 NC_002935.2 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 875978 glmU 2648588 glmU Corynebacterium diphtheriae NCTC 13129 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase NP_939267.1 874524 R 257309 CDS NP_939268.1 38233501 2648589 complement(876064..876960) 1 NC_002935.2 Similar to Pseudomonas aeruginosa probable transcriptional regulator PA3398 TR:Q9HYK6 (EMBL:AE004761) (308 aa) fasta scores: E(): 4e-18, 30.94% id in 265 aa; LysR family transcriptional regulator 876960 2648589 DIP0905 Corynebacterium diphtheriae NCTC 13129 LysR family transcriptional regulator NP_939268.1 876064 R 257309 CDS NP_939269.1 38233502 2648590 877048..878124 1 NC_002935.2 Low similarity to Streptomyces coelicolor integral membrane protein SCI35.39 TR:O88074 (EMBL:AL031541) (394 aa) fasta scores: E(): 1.8e-16, 29.34% id in 351 aa; hypothetical protein 878124 2648590 DIP0906 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939269.1 877048 D 257309 CDS NP_939270.1 38233503 2648591 878149..879078 1 NC_002935.2 Similar to Corynebacterium glutamicum hypothetical 33.0 kDa protein in proB-proA intergenic region SW:YPRA_CORGL (P45637) (304 aa) fasta scores: E(): 7.5e-48, 45.3% id in 309 aa, and to Escherichia coli 2-ketogluconate reductase TkrA or B3553 SW:TKRA_ECOLI (P37666) (324 aa) fasta scores: E(): 1.4e-13, 31.57% id in 247 aa; reductase 879078 2648591 DIP0907 Corynebacterium diphtheriae NCTC 13129 reductase NP_939270.1 878149 D 257309 CDS NP_939271.1 38233504 2648592 879104..880714 1 NC_002935.2 Similar to Corynebacterium striatum ABC transporter TetA TR:Q9Z4Q1 (EMBL:U21300) (513 aa) fasta scores: E(): 1.3e-45, 33.98% id in 509 aa; ABC transporter 880714 2648592 DIP0908 Corynebacterium diphtheriae NCTC 13129 ABC transporter NP_939271.1 879104 D 257309 CDS NP_939272.1 38233505 2648593 880715..882502 1 NC_002935.2 Similar to C-terminal region of Mycobacterium smegmatis ExiT TR:O85018 (EMBL:AF034152) (1122 aa) fasta scores: E(): 5.9e-45, 34.56% id in 596 aa, and to Streptomyces coelicolor ABC-transporter transmembrane protein SCF34.12c TR:Q9RK13 (EMBL:AL109974) (601 aa) fasta scores: E(): 1.5e-42, 33.98% id in 612 aa; ABC transporter ATP-binding protein 882502 2648593 DIP0909 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_939272.1 880715 D 257309 CDS NP_939273.1 38233506 2648595 882775..883422 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 transcriptional regulator, tetR family MT1047 TR:AAK45298 (EMBL:AE006987) (202 aa) fasta scores: E(): 4.4e-45, 63.9% id in 205 aa; TetR family transcriptional regulator 883422 2648595 DIP0910 Corynebacterium diphtheriae NCTC 13129 TetR family transcriptional regulator NP_939273.1 882775 D 257309 CDS NP_939274.1 38233507 2648596 883472..887266 1 NC_002935.2 Similar to Mycobacterium tuberculosis transcription-repair coupling factor Mfd or Rv1020 or MT1048 or MTCY10G2.29c SW:MFD_MYCTU (P96380) (1234 aa) fasta scores: E(): 2e-200, 57.37% id in 1234 aa, and to Escherichia coli transcription-repair coupling factor Mfd or B1114 SW:MFD_ECOLI (P30958) (1148 aa) fasta scores: E(): 7e-103, 36.52% id in 1191 aa; transcription-repair coupling factor 887266 mfd 2648596 mfd Corynebacterium diphtheriae NCTC 13129 transcription-repair coupling factor NP_939274.1 883472 D 257309 CDS NP_939275.1 38233508 2648597 887323..887748 1 NC_002935.2 hypothetical protein 887748 2648597 DIP0912 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939275.1 887323 D 257309 CDS NP_939276.1 38233509 2648598 887751..888233 1 NC_002935.2 hypothetical protein 888233 2648598 DIP0913 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939276.1 887751 D 257309 CDS NP_939277.1 38233510 2648599 complement(888244..889740) 1 NC_002935.2 Similar to Corynebacterium glutamicum L-Lysine transport protein LysI SW:LYSI_CORGL (P35865) (501 aa) fasta scores: E(): 9.3e-131, 69.85% id in 491 aa; L-lysine transport protein 889740 lysI 2648599 lysI Corynebacterium diphtheriae NCTC 13129 L-lysine transport protein NP_939277.1 888244 R 257309 CDS NP_939278.1 38233511 2648600 889839..890537 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 35.4 kDa protein Rv1021 or MTCY10G2.28c TR:P96379 (EMBL:Z92539) (325 aa) fasta scores: E(): 3.2e-20, 38.61% id in 202 aa; hypothetical protein 890537 2648600 DIP0915 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939278.1 889839 D 257309 CDS NP_939279.1 38233512 2648601 890549..891325 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 25.8 kDa protein LpqU or Rv1022 or MTCY10G2.27c TR:P96378 (EMBL:Z92539) (243 aa) fasta scores: E(): 7.2e-34, 46.02% id in 239 aa; hypothetical protein 891325 2648601 DIP0916 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939279.1 890549 D 257309 CDS NP_939280.1 38233513 2648602 891487..892764 1 NC_002935.2 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 892764 eno 2648602 eno Corynebacterium diphtheriae NCTC 13129 phosphopyruvate hydratase NP_939280.1 891487 D 257309 CDS NP_939281.1 38233514 2649957 892885..893418 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 24.6 kDa protein Rv1024 or MTCY10G2.25c TR:P96376 (EMBL:Z92539) (228 aa) fasta scores: E(): 1.5e-08, 31.21% id in 157 aa; hypothetical protein 893418 2649957 DIP0918 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939281.1 892885 D 257309 CDS NP_939282.1 38233515 2649958 893459..894025 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical protein ML0257 TR:Q9CD40 (EMBL:AL583917) (167 aa) fasta scores: E(): 4e-33, 59.49% id in 158 aa; hypothetical protein 894025 2649958 DIP0919 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939282.1 893459 D 257309 CDS NP_939283.1 38233516 2649959 894022..894972 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical 33.5 kDa protein ML0258 or MLCB4.02 TR:O69585 (EMBL:AL023514) (317 aa) fasta scores: E(): 9e-53, 52.56% id in 312 aa; hypothetical protein 894972 2649959 DIP0920 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939283.1 894022 D 257309 CDS NP_939284.1 38233517 2649961 895352..895675 1 NC_002935.2 hypothetical protein 895675 2649961 DIP0921 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939284.1 895352 D 257309 CDS NP_939285.1 38233518 2649962 895787..896794 1 NC_002935.2 Similar to Pseudomonas aeruginosa probable transcriptional regulator PA2488 TR:Q9I0Z4 (EMBL:AE004676) (254 aa) fasta scores: E(): 5.9e-10, 34.66% id in 150 aa, and to Streptomyces coelicolor araC-family transcriptional regulator SC9H11.05 TR:Q9KYN4 (EMBL:AL356592) (289 aa) fasta scores: E(): 3.3e-05, 29.49% id in 217 aa; AraC family transcriptional regulator 896794 2649962 DIP0922 Corynebacterium diphtheriae NCTC 13129 AraC family transcriptional regulator NP_939285.1 895787 D 257309 CDS NP_939286.1 38233519 2649963 896926..897756 1 NC_002935.2 Similar to Mycobacterium tuberculosis transmembrane protein Rv1072 or MTV017.25 TR:O53420 (EMBL:AL021897) (278 aa) fasta scores: E(): 2.4e-47, 58.21% id in 280 aa; hypothetical protein 897756 2649963 DIP0923 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939286.1 896926 D 257309 CDS NP_939287.1 38233520 2649964 complement(897826..898245) 1 NC_002935.2 hypothetical protein 898245 2649964 DIP0924 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939287.1 897826 R 257309 CDS NP_939288.1 38233521 2649965 complement(898245..898766) 1 NC_002935.2 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 898766 greA 2649965 greA Corynebacterium diphtheriae NCTC 13129 transcription elongation factor GreA NP_939288.1 898245 R 257309 CDS NP_939289.1 38233522 2649966 complement(898944..899411) 1 NC_002935.2 Similar to Mycobacterium leprae conserved membrane protein ML2392 TR:Q9CB66 (EMBL:AL583925) (144 aa) fasta scores: E(): 6.2e-10, 33.56% id in 143 aa; hypothetical protein 899411 2649966 DIP0926 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939289.1 898944 R 257309 CDS NP_939290.1 38233523 2649967 899713..900600 1 NC_002935.2 Similar to Mycobacterium leprae LmbE (hypothetical protein ML2391) TR:Q50060 (EMBL:U15183) (290 aa) fasta scores: E(): 9e-62, 55.17% id in 290 aa; hypothetical protein 900600 2649967 DIP0927 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939290.1 899713 D 257309 CDS NP_939291.1 38233524 2649968 900655..900996 1 NC_002935.2 hypothetical protein 900996 2649968 DIP0928 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939291.1 900655 D 257309 CDS NP_939292.1 38233525 2649969 901021..901818 1 NC_002935.2 Similar to Mycobacterium leprae possible undecaprenyl pyrophosphate synthetase ML2467 TR:Q9CB36 (EMBL:AL583925) (262 aa) fasta scores: E(): 4.1e-57, 60% id in 250 aa, and to Bacillus subtilis undecaprenyl pyrophosphate synthetase UppS SW:UPPS_BACSU (O31751) (260 aa) fasta scores: E(): 2.1e-26, 36.84% id in 247 aa; undecaprenyl pyrophosphate synthetase 901818 2649969 DIP0929 Corynebacterium diphtheriae NCTC 13129 undecaprenyl pyrophosphate synthetase NP_939292.1 901021 D 257309 CDS NP_939293.1 38233526 2649970 901865..902365 1 NC_002935.2 hypothetical protein 902365 2649970 DIP0930 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939293.1 901865 D 257309 CDS NP_939294.1 38233527 2649971 complement(902362..903288) 1 NC_002935.2 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 903288 coaA 2649971 coaA Corynebacterium diphtheriae NCTC 13129 pantothenate kinase NP_939294.1 902362 R 257309 CDS NP_939295.1 38233528 2649972 903498..904787 1 NC_002935.2 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 904787 glyA 2649972 glyA Corynebacterium diphtheriae NCTC 13129 serine hydroxymethyltransferase NP_939295.1 903498 D 257309 CDS NP_939296.1 38233529 2649973 complement(904858..905202) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 14.7 kDa protein 2SCG38.16 TR:Q9EX03 (EMBL:AL445503) (132 aa) fasta scores: E(): 1.2e-18, 53.39% id in 103 aa; hypothetical protein 905202 2649973 DIP0933 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939296.1 904858 R 257309 CDS NP_939297.1 38233530 2649974 905267..905947 1 NC_002935.2 Low similarity to Streptomyces coelicolor regulatory protein 2SCG38.15c TR:Q9EX04 (EMBL:AL445503) (278 aa) fasta scores: E(): 2.1e-10, 28.39% id in 236 aa; hypothetical protein 905947 2649974 DIP0934 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939297.1 905267 D 257309 CDS NP_939298.1 38233531 2649975 906029..906595 1 NC_002935.2 Similar to Alcaligenes faecalis phosphinothricin N-acetyltransferase Bar SW:PAT_ALCFA (P31668) (197 aa) fasta scores: E(): 7.8e-08, 31.176% identity in 170 aa overlap and to Streptomyces coelicolor phosphinothricin N-acetyltransferase Bar or SCE22.20 SW:PAT_STRCO (P21861) (171 aa) fasta scores: E(): 5.3e-07, 25.56% id in 176 aa; phosphinothricin N-acetyltransferase 906595 2649975 DIP0935 Corynebacterium diphtheriae NCTC 13129 phosphinothricin N-acetyltransferase NP_939298.1 906029 D 257309 CDS NP_939299.1 38233532 2649976 complement(906600..908165) 1 NC_002935.2 Similar to Streptomyces coelicolor integral membrane transport protein SCC8A.02c TR:Q9KY46 (EMBL:AL356892) (689 aa) fasta scores: E(): 8.5e-70, 42.83% id in 523 aa, and to Mycobacterium tuberculosis CDC1551 drug transporter MT1926 TR:AAK46198 (EMBL:AE007049) (687 aa) fasta scores: E(): 1.1e-57, 37.45% id in 518 aa; drug transport membrane protein 908165 2649976 DIP0936 Corynebacterium diphtheriae NCTC 13129 drug transport membrane protein NP_939299.1 906600 R 257309 CDS NP_939300.1 38233533 2649977 complement(908167..908814) 1 NC_002935.2 Similar to Streptomyces coelicolor tetR-family transcriptional regulator SCF56.06 TR:Q9RD60 (EMBL:AL133424) (213 aa) fasta scores: E(): 4.4e-06, 35.59% id in 118 aa; TetR family transcriptional regulator 908814 2649977 DIP0937 Corynebacterium diphtheriae NCTC 13129 TetR family transcriptional regulator NP_939300.1 908167 R 257309 CDS NP_939301.1 38233534 2649978 complement(908959..910362) 1 NC_002935.2 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 910362 fumC 2649978 fumC Corynebacterium diphtheriae NCTC 13129 fumarate hydratase NP_939301.1 908959 R 257309 CDS NP_939302.1 38233535 2649979 complement(910620..911636) 1 NC_002935.2 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 911636 glpX 2649979 glpX Corynebacterium diphtheriae NCTC 13129 fructose 1,6-bisphosphatase II NP_939302.1 910620 R 257309 CDS NP_939303.1 38233536 2649980 911934..912518 1 NC_002935.2 Low similarity to Mycobacterium tuberculosis hypothetical 24.6 kDa protein Rv1100 or MTV017.53 TR:O53448 (EMBL:AL021897) (233 aa) fasta scores: E(): 8e-06, 28.92% id in 204 aa; hypothetical protein 912518 2649980 DIP0940 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939303.1 911934 D 257309 CDS NP_939304.1 38233537 2649981 complement(912528..912785) 1 NC_002935.2 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 912785 xseB 2649981 xseB Corynebacterium diphtheriae NCTC 13129 exodeoxyribonuclease VII small subunit NP_939304.1 912528 R 257309 CDS NP_939305.1 38233538 2649982 complement(912814..914055) 1 NC_002935.2 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 914055 xseA 2649982 xseA Corynebacterium diphtheriae NCTC 13129 exodeoxyribonuclease VII large subunit NP_939305.1 912814 R 257309 CDS NP_939306.1 38233539 2649983 914162..915163 1 NC_002935.2 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 915163 ispH 2649983 ispH Corynebacterium diphtheriae NCTC 13129 4-hydroxy-3-methylbut-2-enyl diphosphate reductase NP_939306.1 914162 D 257309 CDS NP_939307.1 38233540 2649515 complement(915227..916018) 1 NC_002935.2 hypothetical protein 916018 2649515 DIP0944 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939307.1 915227 R 257309 CDS NP_939308.1 38233541 2649516 complement(916085..917503) 1 NC_002935.2 Similar to Streptomyces coelicolor integral membrane protein SCF6.09 TR:Q9RJL9 (EMBL:AL121849) (363 aa) fasta scores: E(): 2e-46, 44.73% id in 342 aa, and to Escherichia coli permease perm PerM or B2493 or Z3755 or ECS3355 SW:PERM_ECOLI (P77406) (353 aa) fasta scores: E(): 4.7e-17, 29.2% id in 339 aa; hypothetical protein 917503 2649516 DIP0945 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939308.1 916085 R 257309 CDS NP_939309.1 38233542 2649517 complement(917593..917763) 1 NC_002935.2 hypothetical protein 917763 2649517 DIP0946 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939309.1 917593 R 257309 CDS NP_939310.1 38233543 2649518 complement(917763..919412) 1 NC_002935.2 Similar to Pasteurella multocida hypothetical protein PM0718 TR:Q9CMU0 (EMBL:AE006109) (502 aa) fasta scores: E(): 6.7e-106, 57.72% id in 492 aa, and to Haemophilus influenzae hypothetical sodium-dependent transporter HI0736 SW:Y736_HAEIN (P44849) (508 aa) fasta scores: E(): 2.9e-104, 55.17% id in 502 aa; sodium-dependent ABC transport system membrane protein 919412 2649518 DIP0947 Corynebacterium diphtheriae NCTC 13129 sodium-dependent ABC transport system membrane protein NP_939310.1 917763 R 257309 CDS NP_939311.1 38233544 2649519 919766..920851 1 NC_002935.2 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 920851 2649519 DIP0948 Corynebacterium diphtheriae NCTC 13129 GTP-dependent nucleic acid-binding protein EngD NP_939311.1 919766 D 257309 CDS NP_939312.1 38233545 2649520 complement(920928..921842) 1 NC_002935.2 Similar to Deinococcus radiodurans conserved hypothetical protein DR1297 TR:Q9RUT5 (EMBL:AE001977) (311 aa) fasta scores: E(): 2.2e-57, 51.92% id in 312 aa, and to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3176.1 TR:AAK47515 (EMBL:AE007134) (306 aa) fasta scores: E(): 5.1e-55, 54.54% id in 297 aa; ABC transporter 921842 2649520 DIP0949 Corynebacterium diphtheriae NCTC 13129 ABC transporter NP_939312.1 920928 R 257309 CDS NP_939313.1 38233546 2649521 921923..922816 1 NC_002935.2 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 922816 2649521 DIP0950 Corynebacterium diphtheriae NCTC 13129 2-dehydropantoate 2-reductase NP_939313.1 921923 D 257309 CDS NP_939314.1 38233547 2649522 922958..923551 1 NC_002935.2 Similar to Bacillus subtilis YkoE TR:O34738 (EMBL:AJ002571) (199 aa) fasta scores: E(): 5.8e-16, 39.36% id in 188 aa; hypothetical protein 923551 2649522 DIP0951 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939314.1 922958 D 257309 CDS NP_939315.1 38233548 2649523 complement(923566..924588) 1 NC_002935.2 Similar to Neisseria meningitidis chloride channel protein-related protein NMB0982 TR:Q9JZM8 (EMBL:AE002449) (380 aa) fasta scores: E(): 1.4e-21, 31.25% id in 352 aa; chloride channel related membrane protein 924588 2649523 DIP0952 Corynebacterium diphtheriae NCTC 13129 chloride channel related membrane protein NP_939315.1 923566 R 257309 CDS NP_939316.1 38233549 2649524 924885..926264 1 NC_002935.2 Similar to Staphylococcus aureus (strain N315) SA0928 protein or SAV1076 TR:BAB57238 (EMBL:AP003132) (466 aa) fasta scores: E(): 6.9e-32, 34.18% id in 433 aa; ABC transporter ATP-binding protein 926264 2649524 DIP0953 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_939316.1 924885 D 257309 CDS NP_939317.1 38233550 2649525 926261..927016 1 NC_002935.2 Low similarity to Bacillus subtilis YkoC TR:O34572 (EMBL:AJ002571) (254 aa) fasta scores: E(): 1.3e-06, 24.48% id in 241 aa; ABC transporter 927016 2649525 DIP0954 Corynebacterium diphtheriae NCTC 13129 ABC transporter NP_939317.1 926261 D 257309 CDS NP_939318.1 38233551 2649526 927013..927471 1 NC_002935.2 hypothetical protein 927471 2649526 DIP0955 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939318.1 927013 D 257309 CDS NP_939319.1 38233552 2649527 927733..929322 1 NC_002935.2 Similar to Corynebacterium glutamicum ABC-type transporter, periplasmic component CGL1990 SWALL:Q8NP35 (EMBL:AP005280) (534 aa) fasta scores: E(): 7.8e-143, 66.79% id in 533 aa, and to Mycobacterium tuberculosis peptide transport system secreted peptide-binding protein Rv3666c or MTV025.014c or MT3767 SWALL:O69634 (EMBL:AL022121) (541 aa) fasta scores: E(): 6.8e-75, 49.06% id in 534 aa, and to Bacillus subtilis dipeptide-binding protein precursor DppE or DciAE SWALL:DPPE_BACSU (SWALL:P26906) (543 aa) fasta scores: E(): 1.2e-18, 24.49% id in 539 aa; peptide transport system secreted protein 929322 2649527 DIP0956 Corynebacterium diphtheriae NCTC 13129 peptide transport system secreted protein NP_939319.1 927733 D 257309 CDS NP_939320.1 38233553 2649528 929413..930339 1 NC_002935.2 Similar to Mycobacterium tuberculosis peptide transport system permease Rv3665c or MTV025.013c TR:O69633 (EMBL:AL022121) (308 aa) fasta scores: E(): 4.9e-69, 63.48% id in 304 aa, and to Bacillus subtilis oligopeptide transport system permease OppB or Spo0KB SW:OPPB_BACSU (P24138) (311 aa) fasta scores: E(): 1.8e-37, 37.33% id in 308 aa, and to Corynebacterium glutamicum ABC-type transporter, permease components CGL1991 SWALL:Q8NP34 (EMBL:AP005280) (308 aa) fasta scores: E(): 1.5e-95, 84.09% id in 308 aa; peptide transport system membrane protein 930339 2649528 DIP0957 Corynebacterium diphtheriae NCTC 13129 peptide transport system membrane protein NP_939320.1 929413 D 257309 CDS NP_939321.1 38233554 2649529 930332..931285 1 NC_002935.2 Similar to Streptomyces coelicolor peptide transport system integral membrane protein SC9E12.04 TR:Q9F351 (EMBL:AL391751) (305 aa) fasta scores: E(): 1.2e-56, 50.86% id in 289 aa, and to Bacillus subtilis oligopeptide transport system permease OppC or Spo0KC SW:OPPC_BACSU (P24139) (305 aa) fasta scores: E(): 5.5e-35, 36.86% id in 293 aa, and to Corynebacterium glutamicum ABC-type transporter, permease components CGL1992 SWALL:Q8NP33 (EMBL:AP005280) (333 aa) fasta scores: E(): 2.4e-98, 80.32% id in 310 aa; peptide transport system membrane protein 931285 2649529 DIP0958 Corynebacterium diphtheriae NCTC 13129 peptide transport system membrane protein NP_939321.1 930332 D 257309 CDS NP_939322.1 38233555 2649530 931288..932970 1 NC_002935.2 Similar in its full length to Mycobacterium tuberculosis peptide ABC transporter ATP-binding protein Rv3663c or MTV025.011c TR:O69631 (EMBL:AL022121) (548 aa) fasta scores: E(): 4.5e-100, 58.27% id in 544 aa, and N-terminal region and C-termianl region both similar to Bacillus subtilis oligopeptide transport ATP-binding protein OppD or Spo0KD SW:OPPD_BACSU (P24136) (358 aa) fasta scores: E(): 3.1e-38, 46.56% id in 262 aa; peptide ABC transporter ATP-binding protein 932970 2649530 DIP0959 Corynebacterium diphtheriae NCTC 13129 peptide ABC transporter ATP-binding protein NP_939322.1 931288 D 257309 CDS NP_939323.1 38233556 2649531 933397..933699 1 NC_002935.2 hypothetical protein 933699 2649531 DIP0960 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939323.1 933397 D 257309 CDS NP_939324.1 38233557 2649532 933702..934397 1 NC_002935.2 Similar to Bacillus subtilis homologous to many ATP-binding transport proteins YxlF TR:P94374 (EMBL:D83026) (295 aa) fasta scores: E(): 6.4e-12, 31.22% id in 221 aa, and to Escherichia coli, and aliphatic sulfonates transport ATP-binding protein SsuB or B0933 or Z1281 or ECS1016 SW:SSUB_ECOLI (P38053) (255 aa) fasta scores: E(): 3.3e-08, 31.25% id in 208 aa; ABC transporter ATP-binding protein 934397 2649532 DIP0961 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_939324.1 933702 D 257309 CDS NP_939325.1 38233558 2650690 934399..935547 1 NC_002935.2 hypothetical protein 935547 2650690 DIP0962 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939325.1 934399 D 257309 CDS NP_939326.1 38233559 2650691 935552..936139 1 NC_002935.2 hypothetical protein 936139 2650691 DIP0963 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939326.1 935552 D 257309 CDS NP_939327.1 38233560 2650692 complement(937248..937976) 1 NC_002935.2 Similar to Streptomyces coelicolor hydrolase SCBAC14E8.01c TR:Q9ADJ8 (EMBL:AL590435) (228 aa) fasta scores: E(): 0.0013, 30.47% id in 233 aa; protease 937976 2650692 DIP0964 Corynebacterium diphtheriae NCTC 13129 protease NP_939327.1 937248 R 257309 CDS NP_939328.1 38233561 2650693 complement(937977..938321) 1 NC_002935.2 Similar to Escherichia coli arsenate reductase ArsC or ArsG or B3503 SW:ARSC_ECOLI (P37311) (141 aa) fasta scores: E(): 1.8e-14, 48.24% id in 114 aa; arsenate reductase 938321 arsC 2650693 arsC Corynebacterium diphtheriae NCTC 13129 arsenate reductase NP_939328.1 937977 R 257309 CDS NP_939329.1 38233562 2650694 complement(938318..938851) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 hypothetical 16.6 kDa protein MT1668 TR:AAK45938 (EMBL:AE007030) (147 aa) fasta scores: E(): 1.1e-16, 39.43% id in 142 aa; hypothetical protein 938851 2650694 DIP0966 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939329.1 938318 R 257309 CDS NP_939330.1 38233563 2650695 complement(938855..939541) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 hypothetical 36.6 kDa protein MT1193 TR:AAK45450 (EMBL:AE006997) (371 aa) fasta scores: E(): 7.8e-15, 33.91% id in 230 aa; hypothetical protein 939541 2650695 DIP0967 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939330.1 938855 R 257309 CDS NP_939331.1 38233564 2650696 939899..941809 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 GTP-binding elongation factor family protein MT1202 TR:AAK45459 (EMBL:AE006997) (628 aa) fasta scores: E(): 6.7e-148, 67.88% id in 629 aa, and to Escherichia coli GTP-binding protein TypA/BipA TypA or BipA or B3871 SW:TYPA_ECOLI (P32132) (591 aa) fasta scores: E(): 3.3e-58, 46.49% id in 613 aa; GTP-binding elongation factor 941809 2650696 DIP0969 Corynebacterium diphtheriae NCTC 13129 GTP-binding elongation factor NP_939331.1 939899 D 257309 CDS NP_939332.1 38233565 2650697 941820..943349 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 66.1 kDa protein LpqW or Rv1166 or MTV005.02 TR:O50422 (EMBL:AL010186) (635 aa) fasta scores: E(): 4.6e-29, 32.02% id in 381 aa; hypothetical protein 943349 2650697 DIP0970 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939332.1 941820 D 257309 CDS NP_939333.1 38233566 2650698 943349..944230 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 31.7 kDa protein Rv1170 or MTV005.06 TR:O50426 (EMBL:AL010186) (303 aa) fasta scores: E(): 3.9e-27, 40.34% id in 290 aa; hypothetical protein 944230 2650698 DIP0971 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939333.1 943349 D 257309 CDS NP_939334.1 38233567 2650699 944257..944637 1 NC_002935.2 hypothetical protein 944637 2650699 DIP0972 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939334.1 944257 D 257309 CDS NP_939335.1 38233568 2650700 944687..945004 1 NC_002935.2 Highly similar to Saccharopolyspora erythraea ferredoxin FdxA SW:FER_SACER (P24496) (105 aa) fasta scores: E(): 9.3e-32, 76.69% id in 103 aa; ferredoxin 945004 fdxA 2650700 fdxA Corynebacterium diphtheriae NCTC 13129 ferredoxin NP_939335.1 944687 D 257309 CDS NP_939336.1 38233569 2650701 945034..946134 1 NC_002935.2 catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; N-succinyldiaminopimelate aminotransferase 946134 2650701 DIP0974 Corynebacterium diphtheriae NCTC 13129 N-succinyldiaminopimelate aminotransferase NP_939336.1 945034 D 257309 CDS NP_939337.1 38233570 2650702 946181..946912 1 NC_002935.2 Similar to, although shorter than, Mycobacterium tuberculosis CDC1551 RNA pseudouridylate synthase MT3399 TR:AAK47742 (EMBL:AE007148) (305 aa) fasta scores: E(): 3.5e-23, 37.33% id in 233 aa, and similar to Escherichia coli ribosomal large subunit pseudouridine synthase A RluR or B0058 SW:RLUA_ECOLI (P39219) (218 aa) fasta scores: E(): 1.8e-07, 26.76% id in 213 aa; RNA pseudouridylate synthase 946912 2650702 DIP0975 Corynebacterium diphtheriae NCTC 13129 RNA pseudouridylate synthase NP_939337.1 946181 D 257309 CDS NP_939338.1 38233571 2650703 946947..947504 1 NC_002935.2 hypothetical protein 947504 2650703 DIP0976 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939338.1 946947 D 257309 CDS NP_939339.1 38233572 2650704 complement(947511..948695) 1 NC_002935.2 hypothetical protein 948695 2650704 DIP0977 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939339.1 947511 R 257309 CDS NP_939340.1 38233573 2650705 complement(948776..950188) 1 NC_002935.2 Similar to Corynebacterium glutamicum aromatic amino acid transport protein AroP SW:AROP_CORGL (Q46065) (463 aa) fasta scores: E(): 1.1e-91, 56.16% id in 454 aa. Possible duplication of DIP0980 (57.395% identity in 453 aa overlap); aromatic amino acid transporter 950188 aroP1 2650705 aroP1 Corynebacterium diphtheriae NCTC 13129 aromatic amino acid transporter NP_939340.1 948776 R 257309 CDS NP_939341.1 38233574 2650706 complement(950252..951226) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 tetrahydrodipicolinate N-succinyltransferase, MT1239 TR:AAK45496 (EMBL:AE007001) (317 aa) fasta scores: E(): 1.4e-70, 66.35% id in 324 aa, and to Vibrio cholerae 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase VC2329 TR:Q9KPN7 (EMBL:AE004303) (343 aa) fasta scores: E(): 3e-53, 52.16% id in 347 aa. Similar also to DIP0981 (45.614% identity in 285 aa overlap); succinyltransferase 951226 2650706 DIP0979 Corynebacterium diphtheriae NCTC 13129 succinyltransferase NP_939341.1 950252 R 257309 CDS NP_939342.1 38233575 2650707 complement(951237..952601) 1 NC_002935.2 Similar to Corynebacterium glutamicum aromatic amino acid transport protein AroP SW:AROP_CORGL (Q46065) (463 aa) fasta scores: E(): 6.2e-118, 74.27% id in 447 aa, and to Escherichia coli gaba permease GabP or B2663 SW:GABP_ECOLI (P25527) (466 aa) fasta scores: E(): 6.2e-59, 41.03% id in 446 aa. Possible duplication of DIP0978 (57.395% identity in 453 aa overlap); aromatic amino acid transporter 952601 aroP2 2650707 aroP2 Corynebacterium diphtheriae NCTC 13129 aromatic amino acid transporter NP_939342.1 951237 R 257309 CDS NP_939343.1 38233576 2650708 complement(952671..953582) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 tetrahydrodipicolinate N-succinyltransferase, MT1239 TR:AAK45496 (EMBL:AE007001) (317 aa) fasta scores: E(): 3.2e-46, 46.53% id in 303 aa, and C-terminal region to Corynebacterium glutamicum tetrahydrodipicolinate succinylase DapD TR:O69283 (EMBL:AJ004934) (230 aa) fasta scores: E(): 1.6e-28, 45.2% id in 219 aa. Similar also to DIP0979 (45.614% identity in 285 aa overlap); succinyltransferase 953582 2650708 DIP0981 Corynebacterium diphtheriae NCTC 13129 succinyltransferase NP_939343.1 952671 R 257309 CDS NP_939344.1 38233577 2650709 953662..954759 1 NC_002935.2 catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; succinyl-diaminopimelate desuccinylase 954759 dapE 2650709 dapE Corynebacterium diphtheriae NCTC 13129 succinyl-diaminopimelate desuccinylase NP_939344.1 953662 D 257309 CDS NP_939345.1 38233578 2650710 954767..955531 1 NC_002935.2 Similar in its N-terminal region to Corynebacterium glutamicum ORF2 protein TR:Q46063 (EMBL:X81379) (211 aa) fasta scores: E(): 2.5e-63, 76.66% id in 210 aa, and to Streptomyces coelicolor hypothetical 27.5 kDa protein SCP8.03 TR:Q9FBL8 (EMBL:AL390975) (252 aa) fasta scores: E(): 7.5e-60, 64.08% id in 245 aa; hypothetical protein 955531 2650710 DIP0983 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939345.1 954767 D 257309 CDS NP_939346.1 38233579 2650711 955524..956381 1 NC_002935.2 Similar to Mycobacterium leprae dihydropteroate synthase FolP1 or FolP or ML0224 and FolP2 or ML1063 SW:DHPS_MYCLE (P46812) (291 aa) fasta scores: E(): 4.8e-57, 58.69% id in 276 aa, and to Escherichia coli dihydropteroate synthase FolP or DhpS or B3177 SW:DHPS_ECOLI (P26282) (282 aa) fasta scores: E(): 1.2e-25, 35.79% id in 257 aa; dihydropteroate synthase 956381 folP 2650711 folP Corynebacterium diphtheriae NCTC 13129 dihydropteroate synthase NP_939346.1 955524 D 257309 CDS NP_939347.1 38233580 2650712 956378..957127 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 34.0 kDa protein SCD95A.25c TR:Q9KXU9 (EMBL:AL357432) (314 aa) fasta scores: E(): 2.9e-29, 47.67% id in 258 aa, and to Methanothermobacter thermautotrophicus dolichyl-phosphate mannose synthase related protein MTH374 TR:O26474 (EMBL:AE000823) (291 aa) fasta scores: E(): 1.4e-08, 31.89% id in 254 aa; glucosyl-3-phosphoglycerate synthase 957127 2650712 DIP0985 Corynebacterium diphtheriae NCTC 13129 glucosyl-3-phosphoglycerate synthase NP_939347.1 956378 D 257309 CDS NP_939348.1 38233581 2650713 957132..957410 1 NC_002935.2 Similar to, although shorter than, Streptomyces coelicolor secreted protein SCP8.05 TR:Q9FBL6 (EMBL:AL390975) (119 aa) fasta scores: E(): 1.1, 32.09% id in 81 aa; hypothetical protein 957410 2650713 DIP0986 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939348.1 957132 D 257309 CDS NP_939349.1 38233582 2650714 957488..957664 1 NC_002935.2 Similar to C-terminal region of Streptomyces coelicolor conserved hypothetical protein SCP8.08 TR:Q9FBL3 (EMBL:AL390975) (74 aa) fasta scores: E(): 8.5e-11, 60.37% id in 53 aa; hypothetical protein 957664 2650714 DIP0987 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939349.1 957488 D 257309 CDS NP_939350.1 38233583 2650088 957691..958560 1 NC_002935.2 Similar to Micromonospora griseorubida mycinamicin-resistance protein MyrA SW:MYRA_MICGR (P37000) (295 aa) fasta scores: E(): 2.8e-31, 39.51% id in 286 aa, and to Streptomyces fradiae tylosin resistance protein TlrB TR:Q9ZHQ6 (EMBL:AF055922) (280 aa) fasta scores: E(): 2.4e-30, 37.82% id in 267 aa; macrolide resistance protein 958560 2650088 DIP0988 Corynebacterium diphtheriae NCTC 13129 macrolide resistance protein NP_939350.1 957691 D 257309 CDS NP_939351.1 38233584 2649275 complement(958618..960030) 1 NC_002935.2 Similar to the N-terminal region of Pichia jadinii beta-D-fructofuranoside fructohydrolase Inv1 TR:O94224 (EMBL:Y12659) (533 aa) fasta scores: E(): 1.5e-09, 26.33% id in 300 aa, and to the C-terminal region of Pseudomonas mucidolens endo-inulinase TR:Q9RGC0 (EMBL:AF141320) (776 aa) fasta scores: E(): 3.6e-07, 21.77% id in 473 aa; hydrolase 960030 2649275 DIP0989 Corynebacterium diphtheriae NCTC 13129 hydrolase NP_939351.1 958618 R 257309 CDS NP_939352.1 38233585 2649276 complement(960040..960780) 1 NC_002935.2 Similar to Bacillus subtilis alpha-acetolactate decarboxylase AlsD SW:ALDC_BACSU (Q04777) (255 aa) fasta scores: E(): 2.1e-38, 44.78% id in 230 aa; decarboxylase (internal pH control related) 960780 2649276 DIP0990 Corynebacterium diphtheriae NCTC 13129 decarboxylase (internal pH control related) NP_939352.1 960040 R 257309 CDS NP_939353.1 38233586 2649277 complement(960833..962005) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 glycosyl transferase MT1250 TR:AAK45507 (EMBL:AE007001) (387 aa) fasta scores: E(): 2.9e-91, 60.72% id in 387 aa, and to Bacillus subtilis spore coat protein SA CotSA SW:CTSA_BACSU (P46915) (377 aa) fasta scores: E(): 1.6e-13, 24.37% id in 402 aa; glycosyltransferase 962005 2649277 DIP0991 Corynebacterium diphtheriae NCTC 13129 glycosyltransferase NP_939353.1 960833 R 257309 CDS NP_939354.2 161598676 2649278 962100..963326 1 NC_002935.2 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 963326 glgC 2649278 glgC Corynebacterium diphtheriae NCTC 13129 glucose-1-phosphate adenylyltransferase NP_939354.2 962100 D 257309 CDS NP_939355.1 38233588 2649279 complement(963385..964062) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 O-methyltransferase MT1258 TR:AAK45515 (EMBL:AE007002) (215 aa) fasta scores: E(): 6e-17, 37.91% id in 182 aa; methyltransferase 964062 2649279 DIP0993 Corynebacterium diphtheriae NCTC 13129 methyltransferase NP_939355.1 963385 R 257309 CDS NP_939356.1 38233589 2650645 964148..964867 1 NC_002935.2 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence; RNA polymerase sigma factor SigE 964867 2650645 DIP0994 Corynebacterium diphtheriae NCTC 13129 RNA polymerase sigma factor SigE NP_939356.1 964148 D 257309 CDS NP_939357.1 38233590 2650646 964908..965321 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical protein ML1077 TR:Q9CCA5 (EMBL:AL583920) (139 aa) fasta scores: E(): 8e-09, 40.35% id in 114 aa; hypothetical protein 965321 2650646 DIP0995 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939357.1 964908 D 257309 CDS NP_939358.1 38233591 2650647 965352..965795 1 NC_002935.2 Similar to Streptomyces lividans twin arginine translocation complex component TatB TR:Q9EWB3 (EMBL:AJ292256) (158 aa) fasta scores: E(): 1.8e-05, 28.88% id in 135 aa, and to Escherichia coli Sec-independent protein translocase TatB or MttA2 or B3838 or Z5359 or ECS4767 SW:TATB_ECOLI (O69415) (171 aa) fasta scores: E(): 0.0023, 29.33% id in 150 aa; sec-independent translocase 965795 tatB 2650647 tatB Corynebacterium diphtheriae NCTC 13129 sec-independent translocase NP_939358.1 965352 D 257309 CDS NP_939359.1 38233592 2650648 complement(965798..966931) 1 NC_002935.2 Similar to Mycobacterium tuberculosis Mrp protein homolog or Rv1229c or MT1267 or MTCI61.12c or MTV006.01c SW:MRP_MYCTU (O33225) (381 aa) fasta scores: E(): 1.4e-84, 65.21% id in 368 aa; ATP-binding protein 966931 2650648 DIP0997 Corynebacterium diphtheriae NCTC 13129 ATP-binding protein NP_939359.1 965798 R 257309 CDS NP_939360.1 38233593 2650649 complement(966944..967540) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 20.4 kDa protein Rv1231c or MTV006.03c TR:O86314 (EMBL:Z98260) (180 aa) fasta scores: E(): 4.5e-31, 60.81% id in 148 aa; hypothetical protein 967540 2650649 DIP0998 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939360.1 966944 R 257309 CDS NP_939361.1 38233594 2650650 complement(967544..968833) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 hypothetical 47.3 kDa protein MT1270 TR:AAK45528 (EMBL:AE007003) (435 aa) fasta scores: E(): 5e-77, 52.51% id in 417 aa; hypothetical protein 968833 2650650 DIP0999 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939361.1 967544 R 257309 CDS NP_939362.1 38233595 2650651 968959..969468 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 18.6 kDa protein Rv1234 or MTV006.06 TR:O50451 (EMBL:AL021006) (175 aa) fasta scores: E(): 2.9e-27, 56.42% id in 140 aa; hypothetical protein 969468 2650651 DIP1000 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939362.1 968959 D 257309 CDS NP_939363.1 38233596 2650652 969480..970199 1 NC_002935.2 no database matches; hypothetical protein 970199 2650652 DIP1001 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939363.1 969480 D 257309 CDS NP_939364.2 161598675 2650653 complement(970254..973967) 1 NC_002935.2 kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; alpha-ketoglutarate decarboxylase 973967 kgd 2650653 kgd Corynebacterium diphtheriae NCTC 13129 alpha-ketoglutarate decarboxylase NP_939364.2 970254 R 257309 CDS NP_939365.1 38233598 2650654 complement(974130..977870) 1 NC_002935.2 Similar to Streptomyces coelicolor ABC transporter protein, ATP-binding component SCC57A.34c TR:Q9RDG5 (EMBL:AL136519) (1243 aa) fasta scores: E(): 3e-116, 42.18% id in 1247 aa; ABC transporter ATP-binding protein 977870 2650654 DIP1003 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_939365.1 974130 R 257309 CDS NP_939366.1 38233599 2650655 complement(977878..978708) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 27.6 kDa protein Rv1249c or MTV006.21c TR:O50464 (EMBL:AL021006) (262 aa) fasta scores: E(): 2.1e-15, 31.57% id in 209 aa; hypothetical protein 978708 2650655 DIP1004 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939366.1 977878 R 257309 CDS NP_939367.1 38233600 2650656 complement(978917..979228) 1 NC_002935.2 Similar to part of Mycobacterium smegmatis IS1096 TnpA protein TR:Q50440 (EMBL:M76495) (413 aa) fasta scores: E(): 0.7, 29.47% id in 95 aa; transposase remnant 979228 2650656 DIP1005 Corynebacterium diphtheriae NCTC 13129 transposase remnant NP_939367.1 978917 R 257309 CDS NP_939368.1 38233601 2650657 complement(979492..980304) 1 NC_002935.2 catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 980304 aroE 2650657 aroE Corynebacterium diphtheriae NCTC 13129 shikimate 5-dehydrogenase NP_939368.1 979492 R 257309 CDS NP_939369.1 38233602 2650658 980324..981904 1 NC_002935.2 Similar to Bacillus spBP-7. type B carboxylesterase EstA1 TR:Q9L378 (EMBL:AJ278066) (486 aa) fasta scores: E(): 3.2e-47, 34% id in 500 aa, and to Bacillus subtilis para-nitrobenzyl esterase PnbA SW:PNBA_BACSU (P37967) (489 aa) fasta scores: E(): 3.3e-49, 33.93% id in 501 aa; type B carboxylesterase 981904 2650658 DIP1007 Corynebacterium diphtheriae NCTC 13129 type B carboxylesterase NP_939369.1 980324 D 257309 CDS NP_939370.1 38233603 2650659 981926..982735 1 NC_002935.2 hypothetical protein 982735 2650659 DIP1008 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939370.1 981926 D 257309 CDS NP_939371.1 38233604 2650660 982785..983597 1 NC_002935.2 hypothetical protein 983597 2650660 DIP1009 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939371.1 982785 D 257309 CDS NP_939372.1 38233605 2650661 complement(983606..984148) 1 NC_002935.2 hypothetical protein 984148 2650661 DIP1010 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939372.1 983606 R 257309 CDS NP_939373.1 38233606 2650662 984453..985370 1 NC_002935.2 Similar to aldose 1-epimerases e.g. Escherichia coli O157:H7 aldose-1-epimerase ECS4802 TR:BAB38225 (EMBL:AP002567) (300 aa) fasta scores: E(): 3.1e-21, 29.09% id in 299 aa, and to Escherichia coli hypothetical protein YihR or B3879 SW:YIHR_ECOLI (P32139) (308 aa) fasta scores: E(): 7.7e-21, 30.35% id in 280 aa, and to Salmonella typhimurium aldose-1-epimerase YihR TR:Q9L7R7 (EMBL:AF220438) (280 aa) fasta scores: E(): 1.1e-13, 29.53% id in 281 aa. Contains weak match to PFAM:PF01263 Aldose 1-epimerase E: 0.089; aldose 1-epimerase 985370 2650662 DIP1011 Corynebacterium diphtheriae NCTC 13129 aldose 1-epimerase NP_939373.1 984453 D 257309 CDS NP_939374.1 38233607 2650663 985407..987065 1 NC_002935.2 Similar to Streptomyces coelicolor sodium:solute symporter SCE66.18 TR:Q9K3S5 (EMBL:AL359989) (562 aa) fasta scores: E(): 7e-115, 56.42% id in 553 aa, and to Rattus norvegicus sodium-dependent multivitamin transporter slc5a6 or smvT SW:SL56_RAT (O70247) (634 aa) fasta scores: E(): 3.3e-23, 24.2% id in 504 aa; sodium:solute symporter 987065 2650663 DIP1012 Corynebacterium diphtheriae NCTC 13129 sodium:solute symporter NP_939374.1 985407 D 257309 CDS NP_939375.1 38233608 2650664 987078..987359 1 NC_002935.2 Similar to Streptomyces coelicolor membrane protein SCE66.19 TR:Q9K3S4 (EMBL:AL359989) (98 aa) fasta scores: E(): 6.7e-06, 46.15% id in 65 aa; hypothetical protein 987359 2650664 DIP1013 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939375.1 987078 D 257309 CDS NP_939376.1 38233609 2650665 987359..988489 1 NC_002935.2 Similar to Escherichia coli galactose-1-phosphate uridylyltransferase GalT or GalB or B0758 SW:GAL7_ECOLI (P09148) (348 aa) fasta scores: E(): 1.2e-24, 30.34% id in 346 aa, and to Streptomyces lividans galactose-1-phosphate uridylyltransferase GalT SW:GAL7_STRLI (P13212) (354 aa) fasta scores: E(): 4.9e-30, 38.8% id in 384 aa, and to Homo sapiens galactose-1-phosphate uridylyltransferase GalT SW:GAL7_HUMAN (P07902) (379 aa) fasta scores: E(): 8.1e-29, 33.82% id in 340 aa; galactose-1-phosphate uridylyltransferase 988489 galT 2650665 galT Corynebacterium diphtheriae NCTC 13129 galactose-1-phosphate uridylyltransferase NP_939376.1 987359 D 257309 CDS NP_939377.1 38233610 2650666 988473..989702 1 NC_002935.2 Similar to Streptomyces lividans galactokinase GalK SW:GAL1_STRLI (P13227) (397 aa) fasta scores: E(): 1.3e-27, 36.45% id in 384 aa, and to Homo sapiens galactokinase GalK1 or GalK SW:GAL1_HUMAN (P51570) (392 aa) fasta scores: E(): 3e-23, 38.29% id in 410 aa, and to Escherichia coli galactokinase GalK or GalA or B0757 or Z0927 or ECS0785 SW:GAL1_ECOLI (P06976) (381 aa) fasta scores: E(): 1e-11, 32.08% id in 399 aa; galactokinase 989702 galK 2650666 galK Corynebacterium diphtheriae NCTC 13129 galactokinase NP_939377.1 988473 D 257309 CDS NP_939378.1 38233611 2650667 complement(989756..992887) 1 NC_002935.2 Similar to Streptomyces coelicolor helicase SCE20.37 TR:Q9RD88 (EMBL:AL136058) (945 aa) fasta scores: E(): 5.3e-162, 46.4% id in 933 aa, and to Vibrio cholerae helicase-related protein VC0812 TR:Q9KTS6 (EMBL:AE004166) (979 aa) fasta scores: E(): 3.5e-48, 31.6% id in 674 aa; helicase 992887 2650667 DIP1016 Corynebacterium diphtheriae NCTC 13129 helicase NP_939378.1 989756 R 257309 CDS NP_939379.1 38233612 2650668 complement(992898..993293) 1 NC_002935.2 Similar to Staphylococcus aureus (strain N315) SA2278 or SAV2490 TR:BAB58652 (EMBL:AP003137) (130 aa) fasta scores: E(): 1e-24, 56.91% id in 123 aa, and to Escherichia coli CTP pyrophosphohydrolase NudG or B1759 SW:NUDG_ECOLI (P77788) (135 aa) fasta scores: E(): 3.3e-13, 41.4% id in 128 aa; NUDIX family hydrolase 993293 2650668 DIP1017 Corynebacterium diphtheriae NCTC 13129 NUDIX family hydrolase NP_939379.1 992898 R 257309 CDS NP_939380.1 38233613 2650669 993506..995548 1 NC_002935.2 Similar to Mycobacterium tuberculosis cold-shock DEAD-box protein A homolog DeaD or CsdA or Rv1253 or MT1292 or MTCY50.29c SW:DEAD_MYCTU (Q11039) (563 aa) fasta scores: E(): 1.4e-97, 59.85% id in 563 aa, and to Escherichia coli cold-shock DEAD-box protein A DeaD or CsdA or MssB or B3162 SW:DEAD_ECOLI (P23304) (628 aa) fasta scores: E(): 7e-97, 50.32% id in 622 aa; DEAD/DEAH box helicase 995548 deaD 2650669 deaD Corynebacterium diphtheriae NCTC 13129 DEAD/DEAH box helicase NP_939380.1 993506 D 257309 CDS NP_939381.1 38233614 2648603 995636..996046 1 NC_002935.2 no database matches; hypothetical protein 996046 2648603 DIP1019 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939381.1 995636 D 257309 CDS NP_939382.1 38233615 2648604 complement(996175..996639) 1 NC_002935.2 Similar to Streptomyces coelicolor integral membrane protein scf42.06C TR:Q9L2K7 (EMBL:AL137165) (164 aa) fasta scores: E(): 0.0052, 31.54% id in 168 aa, and to Rhizobium meliloti hypothetical transmembrane protein Smc01456 smc01456 TR:CAC46718 (EMBL:AL591789) (144 aa) fasta scores: E(): 0.27, 23.61% id in 144 aa; hypothetical protein 996639 2648604 DIP1020 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939382.1 996175 R 257309 CDS NP_939383.1 38233616 2648605 complement(996688..997278) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 25.9 kDa protein Rv2972c or MTCY349.15 TR:P95123 (EMBL:Z83018) (237 aa) fasta scores: E(): 1.3e-16, 34.7% id in 170 aa, and to Streptomyces coelicolor secreted protein scp1.323c or scp1.31 TR:Q99QB5 (EMBL:AL590464) (219 aa) fasta scores: E(): 2.2e-13, 35.18% id in 162 aa; hypothetical protein 997278 2648605 DIP1021 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939383.1 996688 R 257309 CDS NP_939384.1 38233617 2648606 complement(997318..998883) 1 NC_002935.2 Similar to Corynebacterium glutamicum proline transport system putP TR:O32355 (EMBL:Y09163) (524 aa) fasta scores: E(): 2.3e-143, 69.23% id in 520 aa, and to Escherichia coli sodium/proline symporter putP or B1015 SW:PUTP_ECOLI (P07117) (502 aa) fasta scores: E(): 2.2e-41, 45.69% id in 499 aa; sodium/proline symporter 998883 putP 2648606 putP Corynebacterium diphtheriae NCTC 13129 sodium/proline symporter NP_939384.1 997318 R 257309 CDS NP_939385.1 38233618 2648607 999109..1002198 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 helicase, SNF2/RAD54 family MT2161 TR:AAK46443 (EMBL:AE007065) (954 aa) fasta scores: E(): 7.8e-94, 38.56% id in 1006 aa, and to Synechocystis sp helicase of the SNF2/RAD54 family SLL1366 TR:P74552 (EMBL:D90916) (1039 aa) fasta scores: E(): 1.9e-83, 34.17% id in 986 aa; SNF2/RAD54 family protein 1002198 2648607 DIP1023 Corynebacterium diphtheriae NCTC 13129 SNF2/RAD54 family protein NP_939385.1 999109 D 257309 CDS NP_939386.1 38233619 2648608 1002199..1003020 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 59.8 kDa protein orfZ TR:O86854 (EMBL:AJ007731) (566 aa) fasta scores: E(): 1.2e-07, 31.21% id in 189 aa, and to Sulfolobus solfataricus hypothetical protein Sso1656 sso1656 TR:Q97XQ4 (EMBL:AE006779) (217 aa) fasta scores: E(): 1.1e-06, 25.11% id in 211 aa; hypothetical protein 1003020 2648608 DIP1024 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939386.1 1002199 D 257309 CDS NP_939387.1 38233620 2648609 1003052..1004173 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 exonuclease SbcD-related protein MT1314 TR:AAK45575 (EMBL:AE007006) (417 aa) fasta scores: E(): 3e-43, 40.1% id in 384 aa, and to Bacillus subtilis exonuclease SbcD homolog SW:SBCD_BACSU (P23479) (325 aa) fasta scores: E(): 1.6, 27.13% id in 258 aa; exonuclease SbcD 1004173 2648609 DIP1025 Corynebacterium diphtheriae NCTC 13129 exonuclease SbcD NP_939387.1 1003052 D 257309 CDS NP_939388.1 38233621 2648610 1004173..1006737 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical protein ML1120 TR:Q9CC83 (EMBL:AL583920) (873 aa) fasta scores: E(): 1.9e-14, 28.49% id in 888 aa, and to Mycobacterium tuberculosis hypothetical 93.4 kDa protein Rv1278 or MT1315 or MTCY50.04c SW:YC78_MYCTU (Q11042) (875 aa) fasta scores: E(): 3.3e-13, 29% id in 893 aa. Contains coiled-coil domains, and thus some probably non-specific similarity to e.g. Drosophila melanogaster myosin heavy chain, non-muscle zip SW:MYSN_DROME (Q99323) (2017 aa) fasta scores: E(): 5.7e-07, 23.06% id in 568 aa; ATP-binding protein 1006737 2648610 DIP1026 Corynebacterium diphtheriae NCTC 13129 ATP-binding protein NP_939388.1 1004173 D 257309 CDS NP_939389.1 38233622 2648611 complement(1006815..1007345) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 20.0 kDa protein SC1C2.14C TR:O86515 (EMBL:AL031124) (185 aa) fasta scores: E(): 1e-29, 48.04% id in 179 aa, and to Thermoplasma volcanium hypothetical protein Tvg0219791 TR:BAB59353 (EMBL:AP000991) (177 aa) fasta scores: E(): 2.4e-28, 50.93% id in 161 aa; hypothetical protein 1007345 2648611 DIP1027 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939389.1 1006815 R 257309 CDS NP_939390.1 38233623 2648612 1007587..1008069 1 NC_002935.2 Similar to Streptomyces coelicolor MarR-family transcriptional repressor SCE22.22 TR:Q9KYU1 (EMBL:AL355832) (163 aa) fasta scores: E(): 3.5e-17, 37.06% id in 143 aa, and to Escherichia coli transcriptional repressor MprA EmrR or B2684 or Z3985 or ECS3546 SW:MPRA_ECOLI (P24201) (176 aa) fasta scores: E(): 0.0011, 24.79% id in 121 aa; MarR family transcriptional regulator 1008069 2648612 DIP1028 Corynebacterium diphtheriae NCTC 13129 MarR family transcriptional regulator NP_939390.1 1007587 D 257309 CDS NP_939391.1 38233624 2648613 1008175..1008375 1 NC_002935.2 Similar to Streptomyces coelicolor membrane protein 2SCK8.29C TR:Q9AK23 (EMBL:AL589164) (67 aa) fasta scores: E(): 1.6e-05, 37.03% id in 54 aa, and to Thermotoga maritima conserved hypothetical protein TM1156 TR:Q9X0P0 (EMBL:AE001773) (129 aa) fasta scores: E(): 0.00055, 37.5% id in 56 aa; hypothetical protein 1008375 2648613 DIP1029 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939391.1 1008175 D 257309 CDS NP_939392.1 38233625 2648615 complement(1008712..1009341) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 23.2 kDa protein SCF43A.07 TR:Q9XAA8 (EMBL:AL096837) (215 aa) fasta scores: E(): 3.3e-26, 44.65% id in 215 aa, and to Deinococcus radiodurans conserved hypothetical protein DR1909 TR:Q9RT57 (EMBL:AE002030) (212 aa) fasta scores: E(): 7.8e-17, 37.44% id in 211 aa; hypothetical protein 1009341 2648615 DIP1030 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939392.1 1008712 R 257309 CDS NP_939393.1 38233626 2648616 complement(1009343..1010860) 1 NC_002935.2 Similar to Streptomyces coelicolor iron-sulfur protein SCF43A.06 TR:Q9XAA9 (EMBL:AL096837) (492 aa) fasta scores: E(): 9.1e-97, 57.35% id in 483 aa, and to Escherichia coli electron transport protein YkgF or B0307 SW:YKGF_ECOLI (P77536) (475 aa) fasta scores: E(): 5.4e-64, 39.41% id in 482 aa; iron-sulfur protein 1010860 2648616 DIP1031 Corynebacterium diphtheriae NCTC 13129 iron-sulfur protein NP_939393.1 1009343 R 257309 CDS NP_939394.1 38233627 2648617 complement(1010884..1011669) 1 NC_002935.2 Similar to C-terminus of e.g. Escherichia coli anaerobic glycerol-3-phosphate dehydrogenase subunit C GlpC or B2243 or Z3501 or ECS3128 SW:GLPC_ECOLI (P13034) (396 aa) fasta scores: E(): 2.8e-11, 27.71% id in 249 aa, and to C-terminus of Escherichia coli glycolate oxidase iron-sulfur subunit GlcF or gox or B2978 SW:GLCF_ECOLI (P52074) (407 aa) fasta scores: E(): 9.8e-10, 23.27% id in 232 aa; oxididoreductase subunit 1011669 2648617 DIP1032 Corynebacterium diphtheriae NCTC 13129 oxididoreductase subunit NP_939394.1 1010884 R 257309 CDS NP_939395.1 38233628 2648618 1012107..1013765 1 NC_002935.2 Similar to Escherichia coli L-lactate permease LldP or LctP or B3603 SW:LLDP_ECOLI (P33231) (551 aa) fasta scores: E(): 1e-58, 36.28% id in 554 aa; L-lactate permease 1013765 2648618 DIP1033 Corynebacterium diphtheriae NCTC 13129 L-lactate permease NP_939395.1 1012107 D 257309 CDS NP_939396.1 38233629 2648619 1013777..1015429 1 NC_002935.2 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1015429 argS 2648619 argS Corynebacterium diphtheriae NCTC 13129 arginyl-tRNA synthetase NP_939396.1 1013777 D 257309 CDS NP_939397.1 38233630 2648620 1015432..1016760 1 NC_002935.2 Similar to Corynebacterium glutamicum diaminopimelate decarboxylase LysA SW:DCDA_CORGL (P09890) (445 aa) fasta scores: E(): 2.8e-119, 70.61% id in 439 aa, and to Bacillus subtilis diaminopimelate decarboxylase LysA or Lys SW:DCDA_BACSU (P23630) (441 aa) fasta scores: E(): 3e-67, 43.76% id in 425 aa; diaminopimelate decarboxylase 1016760 lysA 2648620 lysA Corynebacterium diphtheriae NCTC 13129 diaminopimelate decarboxylase NP_939397.1 1015432 D 257309 CDS NP_939398.1 38233631 2648621 1016931..1018277 1 NC_002935.2 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1018277 thrA 2648621 thrA Corynebacterium diphtheriae NCTC 13129 homoserine dehydrogenase NP_939398.1 1016931 D 257309 CDS NP_939399.1 38233632 2648622 1018282..1019208 1 NC_002935.2 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 1019208 thrB 2648622 thrB Corynebacterium diphtheriae NCTC 13129 homoserine kinase NP_939399.1 1018282 D 257309 CDS NP_939400.1 38233633 2648623 complement(1019270..1021021) 1 NC_002935.2 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1021021 2648623 DIP1038 Corynebacterium diphtheriae NCTC 13129 long-chain-fatty-acid--CoA ligase NP_939400.1 1019270 R 257309 CDS NP_939401.1 38233634 2648624 1021371..1023434 1 NC_002935.2 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 1023434 rho 2648624 rho Corynebacterium diphtheriae NCTC 13129 transcription termination factor Rho NP_939401.1 1021371 D 257309 CDS NP_939402.1 38233635 2648625 1023434..1024504 1 NC_002935.2 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1024504 prfA 2648625 prfA Corynebacterium diphtheriae NCTC 13129 peptide chain release factor 1 NP_939402.1 1023434 D 257309 CDS NP_939403.1 38233636 2648626 1024509..1025327 1 NC_002935.2 Similar to Mycobacterium tuberculosis HemK protein homolog HemK or Rv1300 or MT1339 or MTCY373.20 SW:HEMK_MYCTU (Q10602) (304 aa) fasta scores: E(): 2.7e-33, 44.24% id in 278 aa, and to Escherichia coli protein HemK or B1212 SW:HEMK_ECOLI (P37186) (277 aa) fasta scores: E(): 1.2e-16, 29.71% id in 276 aa; HemK family methytransferase 1025327 2648626 DIP1042 Corynebacterium diphtheriae NCTC 13129 HemK family methytransferase NP_939403.1 1024509 D 257309 CDS NP_939404.1 38233637 2650809 1025435..1026085 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 22.6 kDa protein Rv1301 or MT1340 or MTCY373.21 SW:YD01_MYCTU (Q10618) (217 aa) fasta scores: E(): 2.3e-50, 64.92% id in 211 aa, and to Bacillus subtilis hypothetical 37.0 kDa protein in spoIIR-glyC intergenic region YwlC or Ipc-29D SW:YWLC_BACSU (P39153) (346 aa) fasta scores: E(): 1.2e-18, 33.01% id in 206 aa; hypothetical protein 1026085 2650809 DIP1043 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939404.1 1025435 D 257309 CDS NP_939405.1 38233638 2650810 1026086..1027255 1 NC_002935.2 Similar to Mycobacterium tuberculosis undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase Rfe or Rv1302 or MT1341 or MTCY373.22 SW:RFE_MYCTU (Q10606) (404 aa) fasta scores: E(): 1e-75, 56.91% id in 369 aa, and to Bacillus subtilis phospho-N-acetylmuramoyl-pentapeptide-transferase MraY SW:MRAY_BACSU (Q03521) (324 aa) fasta scores: E(): 3.6e-10, 26.53% id in 343 aa; glycosyl trasferase 1027255 2650810 DIP1044 Corynebacterium diphtheriae NCTC 13129 glycosyl trasferase NP_939405.1 1026086 D 257309 CDS NP_939406.1 38233639 2650811 1027273..1027716 1 NC_002935.2 no database matches; hypothetical protein 1027716 2650811 DIP1045 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939406.1 1027273 D 257309 CDS NP_939407.1 38233640 2650812 1028202..1028987 1 NC_002935.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 1028987 atpB 2650812 atpB Corynebacterium diphtheriae NCTC 13129 ATP synthase F0F1 subunit A NP_939407.1 1028202 D 257309 CDS NP_939408.1 38233641 2650813 1029073..1029312 1 NC_002935.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 1029312 atpE 2650813 atpE Corynebacterium diphtheriae NCTC 13129 ATP synthase F0F1 subunit C NP_939408.1 1029073 D 257309 CDS NP_939409.1 38233642 2650814 1029340..1029906 1 NC_002935.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 1029906 atpF 2650814 atpF Corynebacterium diphtheriae NCTC 13129 ATP synthase F0F1 subunit B NP_939409.1 1029340 D 257309 CDS NP_939410.1 38233643 2650815 1029912..1030733 1 NC_002935.2 produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta 1030733 atpH 2650815 atpH Corynebacterium diphtheriae NCTC 13129 ATP synthase F0F1 subunit delta NP_939410.1 1029912 D 257309 CDS NP_939411.1 38233644 2650816 1030794..1032422 1 NC_002935.2 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha 1032422 atpA 2650816 atpA Corynebacterium diphtheriae NCTC 13129 ATP synthase F0F1 subunit alpha NP_939411.1 1030794 D 257309 CDS NP_939412.1 38233645 2650817 1032476..1033453 1 NC_002935.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 1033453 atpG 2650817 atpG Corynebacterium diphtheriae NCTC 13129 ATP synthase F0F1 subunit gamma NP_939412.1 1032476 D 257309 CDS NP_939413.1 38233646 2650818 1033457..1034902 1 NC_002935.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta 1034902 atpD 2650818 atpD Corynebacterium diphtheriae NCTC 13129 ATP synthase F0F1 subunit beta NP_939413.1 1033457 D 257309 CDS NP_939414.1 38233647 2650819 1034916..1035287 1 NC_002935.2 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon 1035287 atpC 2650819 atpC Corynebacterium diphtheriae NCTC 13129 ATP synthase F0F1 subunit epsilon NP_939414.1 1034916 D 257309 CDS NP_939415.1 38233648 2650820 1035514..1035981 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical 16.5 kDa protein ML1147 or u471B SW:YD12_MYCLE (P53432) (147 aa) fasta scores: E(): 4.8e-12, 31.65% id in 139 aa, and to Mycobacterium tuberculosis hypothetical 16.6 kDa protein Rv1312 MT1352 or MTCY373.32 SW:YD12_MYCTU (Q10620) (147 aa) fasta scores: E(): 1.6e-11, 32.37% id in 139 aa, and to Streptomyces coelicolor secreted/membrane protein 2sc6g5.19 TR:Q9K4D3 (EMBL:AL359152) (151 aa) fasta scores: E(): 1.1e-05, 27.97% id in 143 aa; hypothetical protein 1035981 2650820 DIP1054 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939415.1 1035514 D 257309 CDS NP_939416.1 38233649 2650821 1036006..1036695 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 25.1 kDa protein Rv1321 MT1363 or MTCY130.06 SW:YD21_MYCTU (Q10634) (226 aa) fasta scores: E(): 1.8e-66, 73.79% id in 229 aa, and to Mycobacterium leprae hypothetical 24.4 kDa protein MLl1155 or B1549_c3_223 SW:YD21_MYCLE (P53524) (220 aa) fasta scores: E(): 9.1e-64, 72.56% id in 226 aa; hypothetical protein 1036695 2650821 DIP1055 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939416.1 1036006 D 257309 CDS NP_939417.1 38233650 2650822 1036724..1037008 1 NC_002935.2 Similar to Streptomyces coelicolor ATP/GTP-binding protein, doubtful CDS 2SC6G5.35 TR:Q9K4C0 (EMBL:AL359152) (110 aa) fasta scores: E(): 1.1e-12, 46.87% id in 96 aa, and to Mycobacterium tuberculosis hypothetical 11.3 kDa protein Rv1322 MT1363.1 or MTCY130.07 SW:YD22_MYCTU (Q10635) (98 aa) fasta scores: E(): 1.4e-10, 42.22% id in 90 aa; hypothetical protein 1037008 2650822 DIP1056 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939417.1 1036724 D 257309 CDS NP_939418.1 38233651 2650823 complement(1037086..1037544) 1 NC_002935.2 Similar to Mycobacterium leprae B1549_F2_87 ML1157 TR:Q49717 (EMBL:U00014) (155 aa) fasta scores: E(): 1.2e-28, 55.47% id in 137 aa, and to Mycobacterium tuberculosis CDC1551 4-hydroxyphenylpyruvate dioxygenase C terminal domain containing protein MT1364 TR:AAK45627 (EMBL:AE007009) (152 aa) fasta scores: E(): 3e-27, 53.28% id in 137 aa, and to Pyrococcus horikoshii methylmalonyl-CoA epimerase PHO272 TR:AAK52053 (EMBL:AF364548) (136 aa) fasta scores: E(): 9.8e-13, 38.63% id in 132 aa, and to Homo sapiens methylmalonyl-CoA epimerase TR:AAK52052 (EMBL:AF364547) (176 aa) fasta scores: E(): 2.7e-11, 36.84% id in 133 aa; methylmalonyl-CoA epimerase 1037544 2650823 DIP1057 Corynebacterium diphtheriae NCTC 13129 methylmalonyl-CoA epimerase NP_939418.1 1037086 R 257309 CDS NP_939419.1 38233652 2650824 1037621..1037947 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 11.0 kDa protein Rv1898 or MT1949 or MTCY180.20c SW:YI98_MYCTU (O07734) (102 aa) fasta scores: E(): 5.8e-16, 56.43% id in 101 aa, and to Aquifex aeolicus hypothetical 17.9 kDa protein AQ_2067 TR:O67847 (EMBL:AE000771) (157 aa) fasta scores: E(): 4.7e-08, 40.19% id in 102 aa; hypothetical protein 1037947 2650824 DIP1058 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939419.1 1037621 D 257309 CDS NP_939420.1 38233653 2650825 complement(1037950..1038771) 1 NC_002935.2 Similar to Streptomyces coelicolor iron-siderophore uptake system ATP-binding component SCI51.25C TR:Q9S215 (EMBL:AL109848) (301 aa) fasta scores: E(): 1.9e-42, 50.58% id in 255 aa, and to Escherichia coli ferric enterobactin transport ATP-binding protein fepC b0588 SW:FEPC_ECOLI (P23878) (271 aa) fasta scores: E(): 1.1e-41, 49.61% id in 262 aa; iron-siderophore uptake system ATP-binding protein 1038771 2650825 DIP1059 Corynebacterium diphtheriae NCTC 13129 iron-siderophore uptake system ATP-binding protein NP_939420.1 1037950 R 257309 CDS NP_939421.1 38233654 2650826 complement(1038768..1039727) 1 NC_002935.2 Similar to Streptomyces coelicolor iron-siderophore uptake system transmembrane component sci51.26C TR:Q9S214 (EMBL:AL109848) (375 aa) fasta scores: E(): 5e-40, 40.74% id in 324 aa, and to Escherichia coli ferric enterobactin transport system permease fepg fepg or B0589 SW:FEPG_ECOLI (P23877) (330 aa) fasta scores: E(): 1.8e-45, 44.09% id in 322 aa; iron-siderophore uptake system transmembrane protein 1039727 2650826 DIP1060 Corynebacterium diphtheriae NCTC 13129 iron-siderophore uptake system transmembrane protein NP_939421.1 1038768 R 257309 CDS NP_939422.1 38233655 2650827 complement(1039729..1040736) 1 NC_002935.2 Similar to Streptomyces coelicolor iron-siderophore uptake system transmembrane component sci51.27C TR:Q9S213 (EMBL:AL109848) (348 aa) fasta scores: E(): 8e-36, 36.53% id in 323 aa, and to Escherichia coli ferric enterobactin transport system permease fepD or B0590 SW:FEPD_ECOLI (P23876) (334 aa) fasta scores: E(): 5.2e-40, 40.37% id in 322 aa; iron-siderophore uptake system transmembrane protein 1040736 2650827 DIP1061 Corynebacterium diphtheriae NCTC 13129 iron-siderophore uptake system transmembrane protein NP_939422.1 1039729 R 257309 CDS NP_939423.1 38233656 2650828 1040784..1041827 1 NC_002935.2 Similar to Escherichia coli iron(III) dicitrate-binding periplasmic protein precursor FecB or B4290 SW:FECB_ECOLI (P15028) (300 aa) fasta scores: E(): 1.1e-12, 25.55% id in 270 aa, and to Campylobacter jejuni enterochelin uptake periplasmic binding protein CeuE or CJ1355 TR:Q9PMU4 (EMBL:AL139078) (330 aa) fasta scores: E(): 3e-12, 28.35% id in 328 aa, and to Vibrio anguillarum ferric anguibactin-binding protein precursor FatB SW:FATB_VIBAN (P11460) (322 aa) fasta scores: E(): 1.5e-09, 28.72% id in 289 aa; iron-siderophore uptake system exported substrate-binding protein 1041827 2650828 DIP1062 Corynebacterium diphtheriae NCTC 13129 iron-siderophore uptake system exported substrate-binding protein NP_939423.1 1040784 D 257309 CDS NP_939424.1 38233657 2650829 complement(1041924..1042307) 1 NC_002935.2 Weakly similar to Streptomyces coelicolor membrane protein SCL2.30c TR:Q9L269 (EMBL:AL137778) (150 aa) fasta scores: E(): 0.12, 28.3% id in 106 aa; hypothetical protein 1042307 2650829 DIP1063 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939424.1 1041924 R 257309 CDS NP_939425.1 38233658 2650830 1042460..1043356 1 NC_002935.2 Similar to Mycobacterium leprae TrxA SWALL:Q49716 (EMBL:U00014) (255 aa) fasta scores: E(): 7.3e-18, 37.22% id in 223 aa, and to Streptomyces coelicolor thioredoxin SC8F4.23 TR:Q9L2A3 (EMBL:AL137242) (318 aa) fasta scores: E(): 6.6e-10, 34.06% id in 320 aa, and to Corynebacterium nephridii thioredoxin C-1 SW:THI1_CORNE (P00275) (105 aa) fasta scores: E(): 0.11, 25.96% id in 104 aa; thioredoxin-like protein 1043356 2650830 DIP1064 Corynebacterium diphtheriae NCTC 13129 thioredoxin-like protein NP_939425.1 1042460 D 257309 CDS NP_939426.1 38233659 2649325 complement(1043761..1045959) 1 NC_002935.2 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 1045959 glgB 2649325 glgB Corynebacterium diphtheriae NCTC 13129 glycogen branching protein NP_939426.1 1043761 R 257309 CDS NP_939427.1 38233660 2649326 complement(1046014..1048050) 1 NC_002935.2 Similar to Mycobacterium smegmatis glucanase GlgE TR:Q9RP48 (EMBL:AF172946) (697 aa) fasta scores: E(): 2.1e-155, 58.52% id in 692 aa, and to Streptomyces coelicolor alpha-amylase Pep1A TR:Q9L1K2 (EMBL:AL138978) (675 aa) fasta scores: E(): 5.1e-126, 50% id in 662 aa, and to Dictyoglomus thermophilum alpha-amylase 3 AmyC SW:AMY3_DICTH (P14899) (498 aa) fasta scores: E(): 0.17, 23.84% id in 453 aa; alpha-amylase 1048050 2649326 DIP1066 Corynebacterium diphtheriae NCTC 13129 alpha-amylase NP_939427.1 1046014 R 257309 CDS NP_939428.1 38233661 2649327 1048145..1049014 1 NC_002935.2 Similar to Mycobacterium tuberculosis ABC transporter ATP-binding protein Rv3041c or MTV012.56c TR:O53288 (EMBL:AL021287) (287 aa) fasta scores: E(): 3.2e-63, 62.95% id in 278 aa, and to Streptomyces coelicolor ABC transporter ATP-binding subunit SCI5.06c TR:Q9X9Z4 (EMBL:AL079332) (265 aa) fasta scores: E(): 1e-41, 49.41% id in 257 aa; ABC transporter ATP-binding protein 1049014 2649327 DIP1067 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_939428.1 1048145 D 257309 CDS NP_939429.1 38233662 2649328 1049093..1049902 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 31.5 kDa protein Rv3040c or MTV012.55c TR:O53287 (EMBL:AL021287) (288 aa) fasta scores: E(): 4.1e-25, 37.2% id in 258 aa, and to uncultured proteobacterium EBAC31A08 predicted MutT superfamily hydrolase TR:Q9F7R7 (EMBL:AF279106) (264 aa) fasta scores: E(): 8.4e-18, 31.79% id in 239 aa; NUDIX/MutT family hydrolase 1049902 2649328 DIP1068 Corynebacterium diphtheriae NCTC 13129 NUDIX/MutT family hydrolase NP_939429.1 1049093 D 257309 CDS NP_939430.1 38233663 2649329 1049947..1051131 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 39.1 kDa protein Rv3037c or MTV012.52C TR:O53284 (EMBL:AL021287) (358 aa) fasta scores: E(): 3.1e-43, 42.49% id in 353 aa, and to Streptomyces coelicolor Sc6g4.36C protein sc6g4.36C TR:O86799 (EMBL:AL031317) (426 aa) fasta scores: E(): 2.5e-18, 31.36% id in 322 aa; hypothetical protein 1051131 2649329 DIP1069 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939430.1 1049947 D 257309 CDS NP_939431.1 38233664 2649330 1051307..1052101 1 NC_002935.2 Similar to Mycobacterium tuberculosis electron transfer flavoprotein beta-subunit FixA or Rv3029c or MT3113 or MTV012.44c SW:ETFB_MYCTU (O53276) (266 aa) fasta scores: E(): 8.4e-45, 51.31% id in 267 aa; electron transfer flavoprotein subunit beta 1052101 etfB 2649330 etfB Corynebacterium diphtheriae NCTC 13129 electron transfer flavoprotein subunit beta NP_939431.1 1051307 D 257309 CDS NP_939432.1 38233665 2649331 1052119..1053072 1 NC_002935.2 Similar to Mycobacterium tuberculosis electron transfer flavoprotein alpha-subunit EtfA or FixB or Rv3028c or MT3112 or MTV012.43c SW:ETFA_MYCTU (O53275) (318 aa) fasta scores: E(): 1.8e-48, 51.1% id in 317 aa; electron transfer flavoprotein subunit alpha 1053072 etfA 2649331 etfA Corynebacterium diphtheriae NCTC 13129 electron transfer flavoprotein subunit alpha NP_939432.1 1052119 D 257309 CDS NP_939433.1 38233666 2649332 1053532..1054668 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 aminotransferase, class V MT3109 TR:AAK47439 (EMBL:AE007129) (393 aa) fasta scores: E(): 1.1e-52, 45.71% id in 385 aa, and to Mycobacterium tuberculosis NifS-like protein Rv3025c or MTV012.40C TR:O53272 (EMBL:AL021287) (393 aa) fasta scores: E(): 1.1e-52, 45.71% id in 385 aa, and to Ruminococcus flavefaciens cysteine desulfurase IscS or NifS SW:ISCS_RUMFL (O54055) (396 aa) fasta scores: E(): 2.1e-40, 36.48% id in 381 aa; class V aminotransferase 1054668 2649332 DIP1072 Corynebacterium diphtheriae NCTC 13129 class V aminotransferase NP_939433.1 1053532 D 257309 CDS NP_939434.1 38233667 2649333 complement(1054665..1055513) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 30.6 kDa protein 2scc13.11C TR:Q9F3H8 (EMBL:AL442165) (289 aa) fasta scores: E(): 5.6e-28, 36.2% id in 279 aa, and to Neisseria meningitidis (serogroup A), and transferase nma1087 or nmb0869 TR:Q9JQL8 (EMBL:AL162755) (263 aa) fasta scores: E(): 1.6e-09, 26.42% id in 246 aa, and to Escherichia coli spermidine synthase spee or B0121 SW:SPEE_ECOLI (P09158) (287 aa) fasta scores: E(): 0.0013, 28.28% id in 152 aa; transferase 1055513 2649333 DIP1073 Corynebacterium diphtheriae NCTC 13129 transferase NP_939434.1 1054665 R 257309 CDS NP_939435.1 38233668 2649334 1055670..1056770 1 NC_002935.2 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 1056770 mnmA 2649334 mnmA Corynebacterium diphtheriae NCTC 13129 tRNA-specific 2-thiouridylase MnmA NP_939435.1 1055670 D 257309 CDS NP_939436.1 38233669 2649335 1056799..1057866 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical protein ML1706 TR:Q9CBR6 (EMBL:AL583923) (337 aa) fasta scores: E(): 4.5e-19, 32.26% id in 313 aa, and to Mycobacterium tuberculosis CDC1551 vitamin-b12 independent methionine synthase MT3095 TR:AAK47424 (EMBL:AE007129) (337 aa) fasta scores: E(): 1.4e-18, 31.94% id in 313 aa, and to Mycobacterium tuberculosis hypothetical 34.2 kDa protein Rv3015c or MTV012.29C TR:O53262 (EMBL:AL021287) (337 aa) fasta scores: E(): 1.4e-18, 31.94% id in 313 aa; hypothetical protein 1057866 2649335 DIP1075 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939436.1 1056799 D 257309 CDS NP_939437.1 38233670 2649336 complement(1057910..1058614) 1 NC_002935.2 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 1058614 2649336 DIP1076 Corynebacterium diphtheriae NCTC 13129 DNA polymerase III subunit epsilon NP_939437.1 1057910 R 257309 CDS NP_939438.1 38233671 2649337 1058711..1060744 1 NC_002935.2 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 1060744 ligA 2649337 ligA Corynebacterium diphtheriae NCTC 13129 NAD-dependent DNA ligase LigA NP_939438.1 1058711 D 257309 CDS NP_939439.1 38233672 2649338 complement(1060807..1061469) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 23.0 kDa protein Rv3013 or MTV012.27 TR:O53260 (EMBL:AL021287) (218 aa) fasta scores: E(): 2.6e-27, 40.63% id in 219 aa, and to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3093 TR:AAK47422 (EMBL:AE007128) (240 aa) fasta scores: E(): 2.8e-27, 40.63% id in 219 aa, and to Mycobacterium leprae hypothetical 24.4 kDa protein MLCB637.11c TR:O33103 (EMBL:Z99263) (230 aa) fasta scores: E(): 1.3e-26, 40.18% id in 219 aa, and to Mycobacterium leprae hypothetical protein ML1704 TR:Q9CBR7 (EMBL:AL583923) (232 aa) fasta scores: E(): 1.3e-26, 40.18% id in 219 aa; hypothetical protein 1061469 2649338 DIP1078 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939439.1 1060807 R 257309 CDS NP_939440.1 38233673 2649339 1061719..1062018 1 NC_002935.2 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 1062018 gatC 2649339 gatC Corynebacterium diphtheriae NCTC 13129 aspartyl/glutamyl-tRNA amidotransferase subunit C NP_939440.1 1061719 D 257309 CDS NP_939441.1 38233674 2649340 1062018..1063502 1 NC_002935.2 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 1063502 gatA 2649340 gatA Corynebacterium diphtheriae NCTC 13129 aspartyl/glutamyl-tRNA amidotransferase subunit A NP_939441.1 1062018 D 257309 CDS NP_939442.1 38233675 2649341 complement(1063604..1064095) 1 NC_002935.2 Similar to Bacillus halodurans ribosomal-protein (S18)-alanine acetyltransferase BH0547 TR:Q9KFD4 (EMBL:AP001508) (151 aa) fasta scores: E(): 0.0026, 52.83% id in 53 aa, and to Homo sapiens similar to spermidine/spermine N1-acetyl transferase TR:AAH11751 (EMBL:BC011751) (170 aa) fasta scores: E(): 0.0061, 28.85% id in 149 aa; acetyltransferase 1064095 2649341 DIP1081 Corynebacterium diphtheriae NCTC 13129 acetyltransferase NP_939442.1 1063604 R 257309 CDS NP_939443.1 38233676 2649342 1064159..1065574 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 drug transporter MT1289 TR:AAK45547 (EMBL:AE007004) (579 aa) fasta scores: E(): 9.3e-70, 43.87% id in 449 aa, and to Streptomyces coelicolor transmembrane efflux protein SCD82.12 TR:Q9L0L9 (EMBL:AL160431) (490 aa) fasta scores: E(): 5.7e-43, 31.79% id in 456 aa, and to Streptomyces glaucescens tetracenomycin C resistance and export protein TcmA SW:TCMA_STRGA (P39886) (538 aa) fasta scores: E(): 3.5e-39, 31.29% id in 425 aa; major facilitator family transmembrane efflux protein 1065574 2649342 DIP1082 Corynebacterium diphtheriae NCTC 13129 major facilitator family transmembrane efflux protein NP_939443.1 1064159 D 257309 CDS NP_939444.1 38233677 2649343 complement(1065633..1065968) 1 NC_002935.2 Similar to Streptomyces coelicolor membrane protein SCE6.24 TR:Q9KZR4 (EMBL:AL353832) (100 aa) fasta scores: E(): 4.1e-13, 49.47% id in 95 aa; hypothetical protein 1065968 2649343 DIP1083 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939444.1 1065633 R 257309 CDS NP_939445.1 38233678 2649344 1066370..1067410 1 NC_002935.2 Similar to Streptomyces coelicolor FecCD-family membrane transport protein SC2H12.15 TR:Q9K469 (EMBL:AL359215) (368 aa) fasta scores: E(): 2.3e-50, 48.1% id in 343 aa, and to Yersinia pestis hemin transport system permease HmuU YPO0280 SW:HMUU_YERPE (Q56992) (334 aa) fasta scores: E(): 6.8e-30, 36.33% id in 344 aa; iron ABC transporter membrane protein 1067410 2649344 DIP1084 Corynebacterium diphtheriae NCTC 13129 iron ABC transporter membrane protein NP_939445.1 1066370 D 257309 CDS NP_939446.1 38233679 2649345 1067410..1068207 1 NC_002935.2 Similar to Bacillus subtilis ferrichrome transport ATP-binding protein FhuC SW:FHUC_BACSU (P49938) (269 aa) fasta scores: E(): 5.1e-24, 35.15% id in 256 aa, and to Escherichia coli iron(III)dicitrate transport ATP-binding protein FecE or B4287 SW:FECE_ECOLI (P15031) (255 aa) fasta scores: E(): 5.5e-24, 37.86% id in 243 aa; iron ABC transporter ATP-binding protein 1068207 2649345 DIP1085 Corynebacterium diphtheriae NCTC 13129 iron ABC transporter ATP-binding protein NP_939446.1 1067410 D 257309 CDS NP_939447.1 38233680 2649346 1068219..1069283 1 NC_002935.2 Similar to Streptomyces coelicolor iron transport lipoprotein SC2H12.17 TR:Q9K467 (EMBL:AL359215) (345 aa) fasta scores: E(): 8.3e-30, 36.76% id in 321 aa, and to Yersinia pestis hemin-binding periplasmic protein HmuT precursor YPO0281 SW:HMUT_YERPE (Q56991) (279 aa) fasta scores: E(): 0.022, 22.69% id in 282 aa; iron transport system exported solute-binding component 1069283 2649346 DIP1086 Corynebacterium diphtheriae NCTC 13129 iron transport system exported solute-binding component NP_939447.1 1068219 D 257309 CDS NP_939448.1 38233681 2649347 1069391..1070098 1 NC_002935.2 hypothetical protein 1070098 2649347 DIP1087 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939448.1 1069391 D 257309 CDS NP_939449.1 38233682 2649348 1070298..1071326 1 NC_002935.2 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 1071326 pfkA 2649348 pfkA Corynebacterium diphtheriae NCTC 13129 6-phosphofructokinase NP_939449.1 1070298 D 257309 CDS NP_939450.1 38233683 2650831 1071435..1072940 1 NC_002935.2 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 1072940 gatB 2650831 gatB Corynebacterium diphtheriae NCTC 13129 aspartyl/glutamyl-tRNA amidotransferase subunit B NP_939450.1 1071435 D 257309 CDS NP_939451.1 38233684 2650832 1073046..1074143 1 NC_002935.2 Similar to Escherichia coli ORF_O346 B3001 TR:Q46851 (EMBL:U28377) (346 aa) fasta scores: E(): 2.5e-73, 56.21% id in 354 aa, to Streptomyces coelicolor oxidoreductase SC7H9.06 TR:Q9EWJ0 (EMBL:AL450223) (348 aa) fasta scores: E(): 1.6e-65, 58.48% id in 342 aa, and to Homo sapiens voltage-gated potassium channel beta-2 subunit KcnAB2 or KcnA2B or KcnK2 TR:Q13303 (EMBL:U33429) (367 aa) fasta scores: E(): 9.5e-27, 34.74% id in 331 aa; aldo/keto reductase 1074143 2650832 DIP1090 Corynebacterium diphtheriae NCTC 13129 aldo/keto reductase NP_939451.1 1073046 D 257309 CDS NP_939452.1 38233685 2650833 complement(1074172..1074858) 1 NC_002935.2 Similar to Corynebacterium glutamicum lysine exporter protein LysE SW:LYSE_CORGL (P94633) (233 aa) fasta scores: E(): 3.8e-40, 45.02% id in 231 aa, and to Escherichia coli hypothetical protein YggA or B2923 SW:YGGA_ECOLI (P11667) (211 aa) fasta scores: E(): 3.1e-09, 32.44% id in 225 aa; lysine exporter protein 1074858 lysE 2650833 lysE Corynebacterium diphtheriae NCTC 13129 lysine exporter protein NP_939452.1 1074172 R 257309 CDS NP_939453.1 38233686 2650834 1074929..1075810 1 NC_002935.2 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 1075810 lysG 2650834 lysG Corynebacterium diphtheriae NCTC 13129 chromosome replication initiation inhibitor protein NP_939453.1 1074929 D 257309 CDS NP_939454.1 38233687 2650835 complement(1075821..1076903) 1 NC_002935.2 Similar to Streptomyces lividans and S. coelicolor hypothetical 38.1 kDa protein 3SCF60.09 TR:O85700 (EMBL:AF072709) (341 aa) fasta scores: E(): 4.8e-70, 54.38% id in 331 aa, and to Rhodobacter sphaeroides hypothetical 38.5 kDa protein ORF11 TR:O33560 (EMBL:AJ000977) (333 aa) fasta scores: E(): 5.6e-48, 45.28% id in 318 aa; hypothetical protein 1076903 2650835 DIP1093 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939454.1 1075821 R 257309 CDS NP_939455.1 38233688 2650836 1076975..1077727 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 25.9 kDa protein Rv2972c or MTCY349.15 TR:P95123 (EMBL:Z83018) (237 aa) fasta scores: E(): 3.4e-25, 36.55% id in 238 aa, and to Streptomyces coelicolor lipoprotein SCE41.16c TR:Q9F2P3 (EMBL:AL442120) (258 aa) fasta scores: E(): 1.5e-19, 37.86% id in 169 aa. Note: Contains a twin-arginine translocation (TAT) system recognition motif (RRSFIRK) at the N-terminal region; hypothetical protein 1077727 2650836 DIP1094 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939455.1 1076975 D 257309 CDS NP_939456.1 38233689 2650837 1077807..1078934 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical 29.5 kDa protein ML1698 or MLCB637.18 TR:O33110 (EMBL:Z99263) (277 aa) fasta scores: E(): 6.4e-10, 30.79% id in 276 aa, and to Mycobacterium tuberculosis hypothetical 28.9 kDa protein Rv3005c or MTV012.19c TR:O53252 (EMBL:AL021287) (279 aa) fasta scores: E(): 1.3e-08, 28.15% id in 277 aa; hypothetical protein 1078934 2650837 DIP1095 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939456.1 1077807 D 257309 CDS NP_939457.1 38233690 2650838 complement(1079011..1080852) 1 NC_002935.2 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 1080852 ilvD 2650838 ilvD Corynebacterium diphtheriae NCTC 13129 dihydroxy-acid dehydratase NP_939457.1 1079011 R 257309 CDS NP_939458.1 38233691 2650839 complement(1081141..1081626) 1 NC_002935.2 Similar to Mycobacterium tuberculosis low molecular weight protein antigen 6 Cfp6 or Rv3004 or MT3084.1 or MTV012.18 SW:CFP6_MYCTU (O53251) (112 aa) fasta scores: E(): 7.9e-07, 34.57% id in 107 aa; low molecular weight protein antigen 6 1081626 2650839 DIP1097 Corynebacterium diphtheriae NCTC 13129 low molecular weight protein antigen 6 NP_939458.1 1081141 R 257309 CDS NP_939459.1 38233692 2650840 1082013..1083971 1 NC_002935.2 acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase 1 catalytic subunit 1083971 ilvB 2650840 ilvB Corynebacterium diphtheriae NCTC 13129 acetolactate synthase 1 catalytic subunit NP_939459.1 1082013 D 257309 CDS NP_939460.1 38233693 2650841 1083987..1084511 1 NC_002935.2 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 1084511 ilvH 2650841 ilvH Corynebacterium diphtheriae NCTC 13129 acetolactate synthase 3 regulatory subunit NP_939460.1 1083987 D 257309 CDS NP_939461.1 38233694 2650842 1084631..1085644 1 NC_002935.2 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 1085644 ilvC 2650842 ilvC Corynebacterium diphtheriae NCTC 13129 ketol-acid reductoisomerase NP_939461.1 1084631 D 257309 CDS NP_939462.1 38233695 2650843 1085794..1086717 1 NC_002935.2 Similar to Staphylococcus aureus (strain N315) CzrB protein or SA1948 or SAV2146 TR:BAB58308 (EMBL:AP003136) (325 aa) fasta scores: E(): 4e-37, 37.74% id in 302 aa, and to Alcaligenes eutrophus cobalt-zinc-cadmium resistance protein CzcD SW:CZCD_ALCEU (P13512) (316 aa) fasta scores: E(): 9.2e-36, 40.84% id in 284 aa; cation-efflux system integral membrane protein 1086717 2650843 DIP1101 Corynebacterium diphtheriae NCTC 13129 cation-efflux system integral membrane protein NP_939462.1 1085794 D 257309 CDS NP_939463.1 38233696 2650844 1086770..1088578 1 NC_002935.2 Similar to Anabaena sp All3615 protein TR:BAB75314 (EMBL:AP003593) (621 aa) fasta scores: E(): 1.8e-37, 29.29% id in 594 aa, and to Streptomyces coelicolor hypothetical 67.8 kDa protein SC4G2.12c TR:O86684 (EMBL:AL031371) (605 aa) fasta scores: E(): 9.5e-29, 34.55% id in 602 aa; hypothetical protein 1088578 2650844 DIP1102 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939463.1 1086770 D 257309 CDS NP_939464.1 38233697 2650845 1088634..1090115 1 NC_002935.2 hypothetical protein 1090115 2650845 DIP1103 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939464.1 1088634 D 257309 CDS NP_939465.1 38233698 2650846 1090278..1091873 1 NC_002935.2 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 1091873 serA 2650846 serA Corynebacterium diphtheriae NCTC 13129 D-3-phosphoglycerate dehydrogenase NP_939465.1 1090278 D 257309 CDS NP_939466.1 38233699 2650847 1092016..1093035 1 NC_002935.2 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 1093035 leuB 2650847 leuB Corynebacterium diphtheriae NCTC 13129 3-isopropylmalate dehydrogenase NP_939466.1 1092016 D 257309 CDS NP_939467.1 38233700 2650849 1094680..1094859 1 NC_002935.2 Some similarity to Vibrio cholerae DNA polymerase III, epsilon subunit, VC1290 TR:Q9KSG6 (EMBL:AE004208) (236 aa) fasta scores: E(): 0.37, 38.33% id in 60 aa; hypothetical protein 1094859 2650849 DIP1110 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939467.1 1094680 D 257309 CDS NP_939468.1 38233701 2650850 1094905..1095237 1 NC_002935.2 no significant database matches; hypothetical protein 1095237 2650850 DIP1111 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939468.1 1094905 D 257309 CDS NP_939469.1 38233702 2650851 1095311..1096108 1 NC_002935.2 Similar to Mycobacterium tuberculosis possible 2-hydroxyhepta-2,4-diene- 1,7-dioate isomerase Rv2993c or MTV012.07c TR:O53242 (EMBL:AL021287) (239 aa) fasta scores: E(): 2.5e-42, 48.73% id in 238 aa; FAA family hydrolase 1096108 2650851 DIP1112 Corynebacterium diphtheriae NCTC 13129 FAA family hydrolase NP_939469.1 1095311 D 257309 CDS NP_939470.1 38233703 2650852 1096131..1096775 1 NC_002935.2 Similar to Streptomyces coelicolor methyltransferase SCF43A.25c TR:Q9XA90 (EMBL:AL096837) (215 aa) fasta scores: E(): 2.2e-12, 36.23% id in 207 aa; hypothetical protein 1096775 2650852 DIP1113 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939470.1 1096131 D 257309 CDS NP_939471.1 38233704 2650853 complement(1096756..1097889) 1 NC_002935.2 synthesizes isochorismate acid from chorismate; isochorismate synthase 1097889 2650853 DIP1114 Corynebacterium diphtheriae NCTC 13129 isochorismate synthase NP_939471.1 1096756 R 257309 CDS NP_939472.1 38233705 2650854 1097919..1099412 1 NC_002935.2 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 1099412 gltX 2650854 gltX Corynebacterium diphtheriae NCTC 13129 glutamyl-tRNA synthetase NP_939472.1 1097919 D 257309 CDS NP_939473.1 38233706 2650855 1099572..1100606 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 esterase, MT3397 TR:AAK47740 (EMBL:AE007148) (304 aa) fasta scores: E(): 5.3e-09, 30.57% id in 242 aa, and to Piromyces equi cinnamoyl ester hydrolase EstA TR:Q9Y871 (EMBL:AF164516) (536 aa) fasta scores: E(): 1.2e-06, 25.19% id in 258 aa, and to Pseudomonas fluorescens esterase D XynD TR:Q51815 (EMBL:X58956) (583 aa) fasta scores: E(): 5.8e-06, 27.37% id in 274 aa; exported esterase/hydrolase 1100606 2650855 DIP1116 Corynebacterium diphtheriae NCTC 13129 exported esterase/hydrolase NP_939473.1 1099572 D 257309 CDS NP_939474.1 38233707 2650858 complement(1100963..1101508) 1 NC_002935.2 Similar to Streptomyces coelicolor SC10A5.11 protein TR:O54102 (EMBL:AL021529) (198 aa) fasta scores: E(): 8.8e-14, 32.94% id in 170 aa, and to Streptomyces roseosporus WhiR protein TR:P72569 (EMBL:U58281) (179 aa) fasta scores: E(): 1.5e-05, 24.5% id in 151 aa; TetR family transcriptional regulator 1101508 2650858 DIP1117 Corynebacterium diphtheriae NCTC 13129 TetR family transcriptional regulator NP_939474.1 1100963 R 257309 CDS NP_939475.1 38233708 2650859 1101650..1103803 1 NC_002935.2 Similar to Streptomyces coelicolor membrane protein SC10A5.10c SW:MMLB_STRCO (O54101) (847 aa) fasta scores: E(): 5.3e-106, 47.61% id in 733 aa, and to Mycobacterium tuberculosis membrane protein MmpL8 or Rv3823c or MT3931 or MTCY409.07 SW:MML8_MYCTU (O07800) (1089 aa) fasta scores: E(): 1.1e-21, 27.76% id in 461 aa; MmpL family integral membrane protein 1103803 2650859 DIP1118 Corynebacterium diphtheriae NCTC 13129 MmpL family integral membrane protein NP_939475.1 1101650 D 257309 CDS NP_939476.1 38233709 2649920 1103979..1105439 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical protein ML0099 TR:Q9CDB3 (EMBL:AL583917) (336 aa) fasta scores: E(): 7e-07, 27.58% id in 261 aa, and to Mycobacterium tuberculosis hypothetical 35.4 kDa protein Rv3802c or MTV026.07c TR:O53581 (EMBL:AL022076) (336 aa) fasta scores: E(): 4.2e-06, 27.98% id in 243 aa; hypothetical protein 1105439 2649920 DIP1119 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939476.1 1103979 D 257309 CDS NP_939477.1 38233710 2649921 1105526..1105807 1 NC_002935.2 hypothetical protein 1105807 2649921 DIP1120 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939477.1 1105526 D 257309 CDS NP_939478.1 38233711 2649922 1105862..1105996 1 NC_002935.2 Doubtful CDS. No significant database matches; hypothetical protein 1105996 2649922 DIP1121 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939478.1 1105862 D 257309 CDS NP_939479.1 38233712 2649924 1106381..1109089 1 NC_002935.2 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 1109089 ppc 2649924 ppc Corynebacterium diphtheriae NCTC 13129 phosphoenolpyruvate carboxylase NP_939479.1 1106381 D 257309 CDS NP_939480.1 38233713 2649925 complement(1109099..1109488) 1 NC_002935.2 Similar to Streptomyces verticillus PhnA-like protein TR:Q9FB32 (EMBL:AF210249) (117 aa) fasta scores: E(): 3.3e-20, 56.19% id in 121 aa, and to Escherichia coli PhnA protein or B4108 or Z5710 or ECS5090 SW:PHNA_ECOLI (P16680) (111 aa) fasta scores: E(): 7.1e-17, 51.28% id in 117 aa; hypothetical protein 1109488 2649925 DIP1123 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939480.1 1109099 R 257309 CDS NP_939481.1 38233714 2649926 complement(1109532..1110524) 1 NC_002935.2 Similar to Bacillus subtilis biotin synthase BioB SW:BIOB_BACSU (P53557) (335 aa) fasta scores: E(): 1.4e-38, 38.19% id in 322 aa, and to Corynebacterium glutamicum biotin synthase BioB SW:BIOB_CORGL (P46396) (334 aa) fasta scores: E(): 3.1e-31, 35.78% id in 299 aa; biotin synthase 1110524 2649926 DIP1124 Corynebacterium diphtheriae NCTC 13129 biotin synthase NP_939481.1 1109532 R 257309 CDS NP_939482.1 38233715 2649927 1110605..1111162 1 NC_002935.2 Similar to Synechocystis sp. hypothetical 21.9 kDa protein SLL1660 SWALL:P72810 (EMBL:D90901) (194 aa) fasta scores: E(): 2.9e-16, 33.13% id in 166 aa, and to Pseudomonas denitrificans hypothetical 19.2 kDa protein in cobO 3'region SWALL:YCB8_PSEDE (SWALL:P29941) (175 aa) fasta scores: E(): 6.6e-07, 34.24% id in 146 aa; hypothetical protein 1111162 2649927 DIP1125 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939482.1 1110605 D 257309 CDS NP_939483.1 38233716 2649928 complement(1111173..1111898) 1 NC_002935.2 Similar to Mycobacterium tuberculosis probable transcriptional regulator Rv2989 or MT3067 or MTV012.03 SWALL:AAK47396 (EMBL:AL021287) (267 aa) fasta scores: E(): 8.6e-39, 48.26% id in 230 aa, and to Streptomyces coelicolor transcriptional regulator SC1C2.33c SWALL:O86533 (EMBL:AL031124) (238 aa) fasta scores: E(): 7.2e-31, 42.24% id in 232 aa; IclR family transcriptional regulator 1111898 2649928 DIP1126 Corynebacterium diphtheriae NCTC 13129 IclR family transcriptional regulator NP_939483.1 1111173 R 257309 CDS NP_939484.1 38233717 2649929 1111988..1113430 1 NC_002935.2 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 1113430 leuC 2649929 leuC Corynebacterium diphtheriae NCTC 13129 isopropylmalate isomerase large subunit NP_939484.1 1111988 D 257309 CDS NP_939485.1 38233718 2649930 1113442..1114032 1 NC_002935.2 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 1114032 leuD 2649930 leuD Corynebacterium diphtheriae NCTC 13129 isopropylmalate isomerase small subunit NP_939485.1 1113442 D 257309 CDS NP_939486.1 38233719 2649931 complement(1114111..1115121) 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical protein ML1682 SWALL:Q9CBR8 (EMBL:AL583923) (311 aa) fasta scores: E(): 1.4e-40, 42.66% id in 300 aa, and N-terminal region to Streptomyces coelicolor MutT-like protein SCD84.10c SWALL:Q9KZV8 (EMBL:AL353816) (142 aa) fasta scores: E(): 4.4e-13, 42.4% id in 125 aa; hypothetical protein 1115121 2649931 DIP1129 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939486.1 1114111 R 257309 CDS NP_939487.1 38233720 2649932 1115316..1116311 1 NC_002935.2 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 1116311 gpsA 2649932 gpsA Corynebacterium diphtheriae NCTC 13129 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase NP_939487.1 1115316 D 257309 CDS NP_939488.1 38233721 2649933 1116334..1117431 1 NC_002935.2 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 1117431 ddl 2649933 ddl Corynebacterium diphtheriae NCTC 13129 D-alanyl-alanine synthetase A NP_939488.1 1116334 D 257309 CDS NP_939489.1 38233722 2649934 complement(1117438..1118376) 1 NC_002935.2 Similar to Mycobacterium leprae possible secreted protein ML1677 TR:Q9CBS1 (EMBL:AL583923) (191 aa) fasta scores: E(): 8.9e-13, 32.447% id in 188 aa, and to Mycobacterium tuberculosis hypothetical 18.8 kDa protein Rv2980 or MTCY349.07c TR:P95115 (EMBL:Z83018) (181 aa) fasta scores: E(): 1.5e-09, 31.098% id in 164 aa; hypothetical protein 1118376 2649934 DIP1132 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939489.1 1117438 R 257309 CDS NP_939490.1 38233723 2649935 1118468..1119457 1 NC_002935.2 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 1119457 thiL 2649935 thiL Corynebacterium diphtheriae NCTC 13129 thiamine monophosphate kinase NP_939490.1 1118468 D 257309 CDS NP_939491.1 38233724 2649936 1119460..1120128 1 NC_002935.2 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 1120128 ung 2649936 ung Corynebacterium diphtheriae NCTC 13129 uracil-DNA glycosylase NP_939491.1 1119460 D 257309 CDS NP_939492.1 38233725 2649937 1120294..1121799 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 46.7 kDa protein Rv2974c or MTCY349.13 TR:P95121 (EMBL:Z83018) (470 aa) fasta scores: E(): 4e-28, 33.402% id in 485 aa, and to Clostridium acetobutylicum predicted kinase related to hydroxyacetone kinase YloV ortholog CAC1735 TR:AAK79701 (EMBL:AE007682) (547 aa) fasta scores: E(): 3.8e-21, 25.690% id in 471 aa; kinase 1121799 2649937 DIP1135 Corynebacterium diphtheriae NCTC 13129 kinase NP_939492.1 1120294 D 257309 CDS NP_939493.1 38233726 2649938 1121804..1123918 1 NC_002935.2 Similar to Bacillus subtilis ATP-dependent DNA helicase RecG SW:RECG_BACSU (O34942) (682 aa) fasta scores: E(): 3.3e-69, 33.862% id in 694 aa, and to Escherichia coli ATP-dependent DNA helicase RecG or B3652 SW:RECG_ECOLI (P24230) (693 aa) fasta scores: E(): 8.9e-63, 34.765% id in 722 aa; ATP-dependent DNA helicase 1123918 recG 2649938 recG Corynebacterium diphtheriae NCTC 13129 ATP-dependent DNA helicase NP_939493.1 1121804 D 257309 CDS NP_939494.1 38233727 2649939 1123946..1124167 1 NC_002935.2 Similar to C-terminus of Mycobacterium smegmatis pyruvate carboxylase Pyc TR:Q9F843 (EMBL:AF262949) (1127 aa) fasta scores: E(): 1.9e-05, 47.761% id in 67 aa, to Bacillus subtilis YngXX TR:Q9R9I3 (EMBL:AF184956) (73 aa) fasta scores: E(): 0.0043, 36.765% id in 68 aa, and to Propionibacterium freudenreichii shermanii biotin carboxyl carrier protein of methylmalonyl-CoA carboxyl- transferase SW:BCCP_PROFR (P02904) (123 aa) fasta scores: E(): 0.0079, 38.806% id in 67 aa; biotin carboxyl carrier protein 1124167 2649939 DIP1137 Corynebacterium diphtheriae NCTC 13129 biotin carboxyl carrier protein NP_939494.1 1123946 D 257309 CDS NP_939495.1 38233728 2649940 1124164..1124742 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 19.8 kDa protein Rv2966c or MTCY349.21 TR:P95128 (EMBL:Z83018) (188 aa) fasta scores: E(): 2.6e-22, 42.703% id in 185 aa, and to Streptomyces coelicolor methylase SC7A1.11 TR:Q9ZBR2 (EMBL:AL034447) (195 aa) fasta scores: E(): 1.2e-21, 44.505% id in 182 aa; DNA methylase 1124742 2649940 DIP1138 Corynebacterium diphtheriae NCTC 13129 DNA methylase NP_939495.1 1124164 D 257309 CDS NP_939496.1 38233729 2649941 1124750..1125229 1 NC_002935.2 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 1125229 coaD 2649941 coaD Corynebacterium diphtheriae NCTC 13129 phosphopantetheine adenylyltransferase NP_939496.1 1124750 D 257309 CDS NP_939497.1 38233730 2649942 1125316..1125474 1 NC_002935.2 hypothetical protein 1125474 2649942 DIP1140 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939497.1 1125316 D 257309 CDS NP_939498.1 38233731 2649943 1125604..1125777 1 NC_002935.2 hypothetical protein 1125777 2649943 DIP1141 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939498.1 1125604 D 257309 CDS NP_939499.1 38233732 2649944 complement(1125798..1126565) 1 NC_002935.2 Similar to Streptomyces coelicolor ATP-binding protein AtrC SWALL:Q9F3K7 (EMBL:AL391763) (253 aa) fasta scores: E(): 5.1e-58, 68% id in 250 aa, and to Rhizobium sp TAL1145 MidC SWALL:Q9EYT0 (EMBL:AF312768) (265 aa) fasta scores: E(): 1.9e-52, 60.78% id in 255 aa; ABC transporter ATP-binding protein 1126565 atrC 2649944 atrC Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_939499.1 1125798 R 257309 CDS NP_939500.1 38233733 2648807 complement(1126569..1127513) 1 NC_002935.2 Similar to Streptomyces coelicolor permease AtrB SWALL:Q9F3K6 (EMBL:AL391763) (316 aa) fasta scores: E(): 7.1e-49, 50.72% id in 276 aa, and to Rhizobium meliloti amino acid uptake ABC transporter permease RB0674 or SMB21095 SWALL:CAC49074 (EMBL:AL603644) (290 aa) fasta scores: E(): 3.5e-37, 42.96% id in 263 aa; ABC transporter 1127513 2648807 DIP1143 Corynebacterium diphtheriae NCTC 13129 ABC transporter NP_939500.1 1126569 R 257309 CDS NP_939501.1 38233734 2648808 complement(1127571..1128464) 1 NC_002935.2 Similar to Rhizobium spTAL1145 MidA SWALL:Q9EYT2 (EMBL:AF312768) (281 aa) fasta scores: E(): 4.6e-18, 30.36% id in 247 aa, and to Escherichia coli glutamine-binding periplasmic protein precursor GlnH or B0811 or Z1033 or ECS0889 SWALL:GLNH_ECOLI (SWALL:P10344) (248 aa) fasta scores: E(): 1.1e-13, 30.55% id in 252 aa; hypothetical protein 1128464 2648808 DIP1144 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939501.1 1127571 R 257309 CDS NP_939502.1 38233735 2648809 complement(1128534..1129466) 1 NC_002935.2 Similar to Vibrio cholerae hypothetical protein VCA0040 SWALL:Q9KNC5 (EMBL:AE004347) (308 aa) fasta scores: E(): 3.4e-22, 31.48% id in 270 aa, and to Methanothermobacter thermautotrophicus hypothetical 35.5 kDa protein MTH465 SWALL:O26565 (EMBL:AE000831) (319 aa) fasta scores: E(): 2.9e-18, 31.12% id in 241 aa; hypothetical protein 1129466 2648809 DIP1145 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939502.1 1128534 R 257309 CDS NP_939503.1 38233736 2648811 1129828..1132527 1 NC_002935.2 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 1132527 polA 2648811 polA Corynebacterium diphtheriae NCTC 13129 DNA polymerase I NP_939503.1 1129828 D 257309 CDS NP_939504.1 38233737 2648812 complement(1132577..1133344) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 24.3 kDa protein SC7H2.13 SWALL:Q9S2K4 (EMBL:AL109732) (220 aa) fasta scores: E(): 1.4e-39, 50% id in 216 aa, and to Bacillus halodurans BH0355 protein SWALL:Q9KFW5 (EMBL:AP001508) (246 aa) fasta scores: E(): 1.3e-10, 28.51% id in 242 aa; hypothetical protein 1133344 2648812 DIP1147 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939504.1 1132577 R 257309 CDS NP_939505.1 38233738 2648813 1133555..1135015 1 NC_002935.2 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1135015 rpsA 2648813 rpsA Corynebacterium diphtheriae NCTC 13129 30S ribosomal protein S1 NP_939505.1 1133555 D 257309 CDS NP_939506.1 38233739 2648814 complement(1135099..1136511) 1 NC_002935.2 Similar to Pasteurella multocida hypothetical protein PM0933 SWALL:Q9CMA1 (EMBL:AE006132) (462 aa) fasta scores: E(): 9.1e-43, 32.62% id in 469 aa, and to Escherichia coli anaerobic C4-dicarboxylate transporter DcuC or B0621 or Z0766 or ECS0660 SWALL:DCUC_ECOLI (SWALL:Q47134) (461 aa) fasta scores: E(): 9.6e-19, 31.76% id in 466 aa; transporter 1136511 2648814 DIP1149 Corynebacterium diphtheriae NCTC 13129 transporter NP_939506.1 1135099 R 257309 CDS NP_939507.1 38233740 2648815 complement(1136731..1137558) 1 NC_002935.2 Similar to Bacillus subtilis transcription antiterminator LicT or N15A SWALL:LICT_BACSU (SWALL:P39805) (277 aa) fasta scores: E(): 2.6e-20, 28.72% id in 275 aa, and to Escherichia coli cryptic beta-glucoside Bgl operon antiterminator BglG or BglC or B3723 SWALL:BGLG_ECOLI (SWALL:P11989) (278 aa) fasta scores: E(): 1.4e-18, 27.33% id in 278 aa; transcription antiterminator 1137558 2648815 DIP1150 Corynebacterium diphtheriae NCTC 13129 transcription antiterminator NP_939507.1 1136731 R 257309 CDS NP_939508.1 38233741 2648816 complement(1137670..1139700) 1 NC_002935.2 Similar to Corynebacterium glutamicum PTS system, glucose-specific IIABC component PtsG SWALL:PTGA_CORGL (SWALL:Q45298) (674 aa) fasta scores: E(): 2.8e-59, 44.91% id in 688 aa, and to Staphylococcus xylosus PTS system, sucrose-specific IIBC component ScrA SWALL:PTSB_STAXY (SWALL:P51184) (480 aa) fasta scores: E(): 8e-26, 27.73% id in 494 aa; PTS system glucose-specific transporter subunit IIABC 1139700 ptsG 2648816 ptsG Corynebacterium diphtheriae NCTC 13129 PTS system glucose-specific transporter subunit IIABC NP_939508.1 1137670 R 257309 CDS NP_939509.1 38233742 2648817 1140082..1140684 1 NC_002935.2 Similar to Corynebacterium glutamicum dephospho-CoA kinase CoaE SWALL:COAE_CORGL (SWALL:P56187) (195 aa) fasta scores: E(): 7.6e-25, 50.81% id in 185 aa, and to Escherichia coli dephospho-CoA kinase CoaE or B0103 or Z0113 or ECS0107 SWALL:COAE_ECOLI (SWALL:P36679) (206 aa) fasta scores: E(): 2.4e-15, 38.37% id in 185 aa; dephospho-CoA kinase 1140684 coaE 2648817 coaE Corynebacterium diphtheriae NCTC 13129 dephospho-CoA kinase NP_939509.1 1140082 D 257309 CDS NP_939510.1 38233743 2648479 1140904..1142103 1 NC_002935.2 Similar to Archaeoglobus fulgidus coenzyme PQQ synthesis protein AF2413 SWALL:O30258 (EMBL:AE001109) (375 aa) fasta scores: E(): 1.1e-54, 40.79% id in 375 aa, and to Methylobacterium extorquens coenzyme PQQ synthesis protein E PqqE SWALL:PQQE_METEX (SWALL:P71517) (384 aa) fasta scores: E(): 1e-05, 24.67% id in 381 aa; coenzyme PQQ synthesis-like protein 1142103 2648479 DIP1153 Corynebacterium diphtheriae NCTC 13129 coenzyme PQQ synthesis-like protein NP_939510.1 1140904 D 257309 CDS NP_939511.1 38233744 2648480 1142204..1144249 1 NC_002935.2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1144249 uvrB 2648480 uvrB Corynebacterium diphtheriae NCTC 13129 excinuclease ABC subunit B NP_939511.1 1142204 D 257309 CDS NP_939512.1 38233745 2648481 1144478..1144918 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 universal stress protein family MT1672 SWALL:AAK45942 (EMBL:AE007031) (146 aa) fasta scores: E(): 1.4e-19, 49.31% id in 146 aa, and to Rhizobium meliloti hypothetical protein RA0598 or SMA1100 SWALL:AAK65256 (EMBL:AE007249) (153 aa) fasta scores: E(): 6.8e-07, 38.37% id in 86 aa; stress-like protein 1144918 2648481 DIP1155 Corynebacterium diphtheriae NCTC 13129 stress-like protein NP_939512.1 1144478 D 257309 CDS NP_939513.1 38233746 2648482 complement(1144967..1147279) 1 NC_002935.2 Similar to Streptomyces coelicolor helicase SCE59.11c SWALL:Q9L1U3 (EMBL:AL138851) (744 aa) fasta scores: E(): 5.4e-32, 34.77% id in 788 aa, and to Clostridium acetobutylicum superfamily I DNA helicase CAC1026 SWALL:AAK79002 (EMBL:AE007618) (763 aa) fasta scores: E(): 2e-15, 23.98% id in 788 aa; helicase 1147279 2648482 DIP1156 Corynebacterium diphtheriae NCTC 13129 helicase NP_939513.1 1144967 R 257309 CDS NP_939514.1 38233747 2648557 complement(1147403..1148248) 1 NC_002935.2 N-terminal region similar to Streptomyces coelicolor hypothetical 18.8 kDa protein SC9H11.26c SWALL:Q9KYL5 (EMBL:AL356592) (177 aa) fasta scores: E(): 9.8e-11, 35.13% id in 148 aa. Note: Possible colied-coil region at C-terminal domain from residue 242 till the end; hypothetical protein 1148248 2648557 DIP1157 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939514.1 1147403 R 257309 CDS NP_939515.1 38233748 2648558 complement(1148433..1149080) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 metallo-beta-lactamase superfamily protein MT1673 SWALL:AAK45943 (EMBL:AE007031) (264 aa) fasta scores: E(): 5e-29, 45.58% id in 204 aa, and to Streptomyces coelicolor hydrolase SCC54.20 SWALL:Q9Z505 (EMBL:AL035591) (218 aa) fasta scores: E(): 7.2e-26, 40.55% id in 217 aa; hydrolase 1149080 2648558 DIP1158 Corynebacterium diphtheriae NCTC 13129 hydrolase NP_939515.1 1148433 R 257309 CDS NP_939516.1 38233749 2648559 1149234..1152095 1 NC_002935.2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 1152095 uvrA 2648559 uvrA Corynebacterium diphtheriae NCTC 13129 excinuclease ABC subunit A NP_939516.1 1149234 D 257309 CDS NP_939517.1 38233750 2648560 1152383..1152886 1 NC_002935.2 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1152886 infC 2648560 infC Corynebacterium diphtheriae NCTC 13129 translation initiation factor IF-3 NP_939517.1 1152383 D 257309 CDS NP_939518.1 38233751 2648561 1152916..1153110 1 NC_002935.2 Similar to Streptomyces coelicolor 50S ribosomal protein L35 RpmI or SCI35.21c SWALL:RL35_STRCO (SWALL:O88059) (64 aa) fasta scores: E(): 1.1e-10, 58.06% id in 62 aa, and to Bacillus subtilis 50S ribosomal protein L35 RpmI SWALL:RL35_BACSU (SWALL:P55874) (65 aa) fasta scores: E(): 1.5e-07, 50% id in 60 aa; 50S ribosomal protein L35 1153110 rpmI 2648561 rpmI Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L35 NP_939518.1 1152916 D 257309 CDS NP_939519.1 38233752 2648562 1153172..1153555 1 NC_002935.2 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1153555 rplT 2648562 rplT Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L20 NP_939519.1 1153172 D 257309 CDS NP_939520.1 38233753 2648563 complement(1153805..1154350) 1 NC_002935.2 hypothetical protein 1154350 2648563 DIP1163 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939520.1 1153805 R 257309 CDS NP_939521.1 38233754 2648564 1154597..1155415 1 NC_002935.2 Similar to Mycobacterium tuberculosis TsnR or Rv1644 or MT1682 or MTCY06H11.08 SWALL:AAK45951 (EMBL:Z85982) (260 aa) fasta scores: E(): 2.4e-45, 52.85% id in 263 aa, and to Mycobacterium leprae rRNA methyltransferase TsnR or ML1397 SWALL:Q9CC19 (EMBL:AL583921) (259 aa) fasta scores: E(): 6.7e-45, 52.89% id in 259 aa, and to Bacillus halodurans rRNA methylase BH3112 SWALL:Q9K894 (EMBL:AP001517) (251 aa) fasta scores: E(): 3.2e-17, 35.24% id in 244 aa; rRNA methyltransferase 1155415 tsnR 2648564 tsnR Corynebacterium diphtheriae NCTC 13129 rRNA methyltransferase NP_939521.1 1154597 D 257309 CDS NP_939522.1 38233755 2648565 1155546..1156601 1 NC_002935.2 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1156601 pheS 2648565 pheS Corynebacterium diphtheriae NCTC 13129 phenylalanyl-tRNA synthetase subunit alpha NP_939522.1 1155546 D 257309 CDS NP_939523.1 38233756 2648566 1156643..1159153 1 NC_002935.2 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1159153 pheT 2648566 pheT Corynebacterium diphtheriae NCTC 13129 phenylalanyl-tRNA synthetase subunit beta NP_939523.1 1156643 D 257309 CDS NP_939524.1 38233757 2648567 1159280..1160323 1 NC_002935.2 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 1160323 argC 2648567 argC Corynebacterium diphtheriae NCTC 13129 N-acetyl-gamma-glutamyl-phosphate reductase NP_939524.1 1159280 D 257309 CDS NP_939525.1 38233758 2648568 1160398..1161558 1 NC_002935.2 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase 1161558 argJ 2648568 argJ Corynebacterium diphtheriae NCTC 13129 bifunctional ornithine acetyltransferase/N-acetylglutamate synthase NP_939525.1 1160398 D 257309 CDS NP_939526.1 38233759 2648569 1161595..1162527 1 NC_002935.2 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 1162527 argB 2648569 argB Corynebacterium diphtheriae NCTC 13129 acetylglutamate kinase NP_939526.1 1161595 D 257309 CDS NP_939527.1 38233760 2649722 1162520..1163761 1 NC_002935.2 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; acetylornithine aminotransferase 1163761 argD 2649722 argD Corynebacterium diphtheriae NCTC 13129 acetylornithine aminotransferase NP_939527.1 1162520 D 257309 CDS NP_939528.1 38233761 2649723 1163790..1164749 1 NC_002935.2 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; ornithine carbamoyltransferase 1164749 argF 2649723 argF Corynebacterium diphtheriae NCTC 13129 ornithine carbamoyltransferase NP_939528.1 1163790 D 257309 CDS NP_939529.1 38233762 2649724 1164856..1165347 1 NC_002935.2 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor ArgR 1165347 argR 2649724 argR Corynebacterium diphtheriae NCTC 13129 arginine repressor ArgR NP_939529.1 1164856 D 257309 CDS NP_939530.1 38233763 2649725 1165505..1166704 1 NC_002935.2 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 1166704 argG 2649725 argG Corynebacterium diphtheriae NCTC 13129 argininosuccinate synthase NP_939530.1 1165505 D 257309 CDS NP_939531.1 38233764 2649726 1166704..1168137 1 NC_002935.2 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 1168137 argH 2649726 argH Corynebacterium diphtheriae NCTC 13129 argininosuccinate lyase NP_939531.1 1166704 D 257309 CDS NP_939532.1 38233765 2649727 1168201..1168413 1 NC_002935.2 Similar to Caulobacter crescentus hypothetical protein CC0108 SWALL:Q9ABW2 (EMBL:AE005685) (65 aa) fasta scores: E(): 9.4e-08, 44.64% id in 56 aa, and to Mycobacterium tuberculosis hypothetical 8.3 kDa protein Rv1684 or MTCI125.06 SWALL:O33186 (EMBL:Z98268) (74 aa) fasta scores: E(): 2.1e-07, 57.69% id in 52 aa. Note: Two possible alternative start codons at residues 8 or 11; hypothetical protein 1168413 2649727 DIP1175 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939532.1 1168201 D 257309 CDS NP_939533.1 38233766 2649728 1168427..1169689 1 NC_002935.2 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1169689 tyrS 2649728 tyrS Corynebacterium diphtheriae NCTC 13129 tyrosyl-tRNA synthetase NP_939533.1 1168427 D 257309 CDS NP_939534.1 38233767 2649732 1175639..1176715 1 NC_002935.2 C-terminal region similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT1730 SWALL:AAK45999 (EMBL:AE007035) (250 aa) fasta scores: E(): 4e-32, 47.73% id in 243 aa, and to Streptomyces coelicolor hypothetical 22.8 kDa protein SCI51.30c SWALL:Q9S210 (EMBL:AL109848) (210 aa) fasta scores: E(): 3.1e-24, 49.17% id in 181 aa; hypothetical protein 1176715 2649732 DIP1177 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939534.1 1175639 D 257309 CDS NP_939535.1 38233768 2649733 1176792..1177748 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT1731 SWALL:AAK46000 (EMBL:AE007035) (353 aa) fasta scores: E(): 1e-33, 41.06% id in 302 aa, and to Streptomyces coelicolor hypothetical 35.2 kDa protein SCI51.28c SWALL:Q9S212 (EMBL:AL109848) (343 aa) fasta scores: E(): 4e-32, 39.4% id in 302 aa; hypothetical protein 1177748 2649733 DIP1178 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939535.1 1176792 D 257309 CDS NP_939536.1 38233769 2649734 1177766..1177927 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 1177927 2649734 DIP1179 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939536.1 1177766 D 257309 CDS NP_939537.1 38233770 2649735 1177969..1178790 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 cytotoxin/hemolysin MT1733 SWALL:AAK46002 (EMBL:AE007035) (268 aa) fasta scores: E(): 2.2e-53, 56.56% id in 274 aa, and to Caulobacter crescentus hemolysin A CC1324 SWALL:Q9A8M9 (EMBL:AE005808) (243 aa) fasta scores: E(): 1.2e-29, 42.27% id in 246 aa; cytotoxin/hemolysin 1178790 2649735 DIP1180 Corynebacterium diphtheriae NCTC 13129 cytotoxin/hemolysin NP_939537.1 1177969 D 257309 CDS NP_939538.1 38233771 2649736 1178790..1179743 1 NC_002935.2 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 1179743 ppnK 2649736 ppnK Corynebacterium diphtheriae NCTC 13129 inorganic polyphosphate/ATP-NAD kinase NP_939538.1 1178790 D 257309 CDS NP_939539.1 38233772 2649737 1179859..1181598 1 NC_002935.2 Similar to Mycobacterium tuberculosis DNA repair protein RecN or Rv1696 or MT1735 or MTCI125.18 SWALL:RECN_MYCTU (SWALL:O33197) (587 aa) fasta scores: E(): 1.9e-53, 47.99% id in 598 aa, and to Streptomyces coelicolor DNA repair protein RecN or SCI51.20c SWALL:RECN_STRCO (SWALL:Q9S220) (572 aa) fasta scores: E(): 1.2e-54, 45.64% id in 585 aa, and to Bacillus subtilis DNA repair protein RecN SWALL:RECN_BACSU (SWALL:P17894) (576 aa) fasta scores: E(): 2.5e-38, 32.31% id in 591 aa; DNA repair protein 1181598 recN 2649737 recN Corynebacterium diphtheriae NCTC 13129 DNA repair protein NP_939539.1 1179859 D 257309 CDS NP_939540.1 38233773 2649738 1181709..1182902 1 NC_002935.2 Similar to Mycobacterium leprae conserved membrane protein ML1361 SWALL:Q9CC30 (EMBL:AL583921) (393 aa) fasta scores: E(): 7.2e-57, 44.16% id in 394 aa, and to Mycobacterium tuberculosis hypothetical 42.4 kDa protein Rv1697 or MTCI125.19 SWALL:O33198 (EMBL:Z98268) (393 aa) fasta scores: E(): 2.9e-56, 43.4% id in 394 aa; hypothetical protein 1182902 2649738 DIP1183 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939540.1 1181709 D 257309 CDS NP_939541.1 38233774 2649739 1182927..1183877 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 32.4 kDa protein Rv1698 precursor or MT1737 or MTCI125.20 SWALL:YG98_MYCTU (SWALL:P58212) (314 aa) fasta scores: E(): 4.4e-22, 31.57% id in 304 aa; hypothetical protein 1183877 2649739 DIP1184 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939541.1 1182927 D 257309 CDS NP_939542.1 38233775 2649740 1183899..1184537 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 MutT/NudXx family protein MT1739 SWALL:AAK46008 (EMBL:AE007036) (207 aa) fasta scores: E(): 6.7e-35, 48.3% id in 207 aa, and to Bacillus subtilis ADP-ribose pyrophosphatase NudF SWALL:ADPP_BACSU (SWALL:P54570) (185 aa) fasta scores: E(): 7.9e-15, 35.06% id in 154 aa; hypothetical protein 1184537 2649740 DIP1185 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939542.1 1183899 D 257309 CDS NP_939543.1 38233776 2649741 1184540..1185475 1 NC_002935.2 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 1185475 xerD 2649741 xerD Corynebacterium diphtheriae NCTC 13129 site-specific tyrosine recombinase XerD NP_939543.1 1184540 D 257309 CDS NP_939544.1 38233777 2649742 1185667..1186536 1 NC_002935.2 Similar to Mycobacterium leprae possible regulatory protein ML1367 SWALL:Q9CC29 (EMBL:AL583921) (287 aa) fasta scores: E(): 1.8e-76, 72.72% id in 275 aa, and to Bacillus subtilis sporulation initiation inhibitor protein Soj SWALL:SOJ_BACSU (SWALL:P37522) (253 aa) fasta scores: E(): 1.2e-44, 51.21% id in 248 aa; regulatory protein 1186536 2649742 DIP1187 Corynebacterium diphtheriae NCTC 13129 regulatory protein NP_939544.1 1185667 D 257309 CDS NP_939545.1 38233778 2649743 1186579..1187397 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 30.6 kDa protein Rv1709 or MTCI125.31 SWALL:O33208 (EMBL:Z98268) (278 aa) fasta scores: E(): 2.2e-55, 60.31% id in 252 aa, and to Streptomyces coelicolor hypothetical 29.6 kDa protein SCI51.10c SWALL:Q9S230 (EMBL:AL109848) (264 aa) fasta scores: E(): 1.2e-46, 59.41% id in 239 aa; hypothetical protein 1187397 2649743 DIP1188 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939545.1 1186579 D 257309 CDS NP_939546.1 38233779 2649744 1187512..1188117 1 NC_002935.2 Similar to Corynebacterium glutamicum dethiobiotin synthetase BioD SWALL:BIOD_CORGL (SWALL:P46397) (224 aa) fasta scores: E(): 4e-08, 38.94% id in 208 aa, and to Streptomyces coelicolor dethiobiotin synthetase BioD SWALL:Q9FCC1 (EMBL:AL391014) (238 aa) fasta scores: E(): 3.6e-06, 28.37% id in 222 aa. Note: Similar to the downstream CDS DIP1192, 222 aa; E(): 1.3e-13; 38.914% identity in 221 aa overlap - possible duplication; dethiobiotin synthetase 1188117 bioD1 2649744 bioD1 Corynebacterium diphtheriae NCTC 13129 dethiobiotin synthetase NP_939546.1 1187512 D 257309 CDS NP_939547.1 38233780 2649745 complement(1188118..1189614) 1 NC_002935.2 Similar to Bacillus subtilis hypothetical transporter YclF SWALL:YCLF_BACSU (SWALL:P94408) (492 aa) fasta scores: E(): 2e-53, 33.73% id in 495 aa, and to Neisseria meningitidis peptide transporter NMA0222 SWALL:Q9JWV5 (EMBL:AL162752) (485 aa) fasta scores: E(): 6.2e-47, 34.63% id in 488 aa; peptide transport protein 1189614 2649745 DIP1190 Corynebacterium diphtheriae NCTC 13129 peptide transport protein NP_939547.1 1188118 R 257309 CDS NP_939548.1 38233781 2649746 1189692..1190987 1 NC_002935.2 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 1190987 bioA 2649746 bioA Corynebacterium diphtheriae NCTC 13129 adenosylmethionine-8-amino-7-oxononanoate aminotransferase NP_939548.1 1189692 D 257309 CDS NP_939549.1 38233782 2649747 1191000..1191668 1 NC_002935.2 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 1191668 bioD 2649747 bioD Corynebacterium diphtheriae NCTC 13129 dithiobiotin synthetase NP_939549.1 1191000 D 257309 CDS NP_939550.1 38233783 2649748 1191785..1193359 1 NC_002935.2 Similar to Streptomyces coelicolor Na+/H+ antiporter SC4A10.04c SWALL:Q9S2Y0 (EMBL:AL109663) (528 aa) fasta scores: E(): 1.2e-47, 39.09% id in 532 aa, and to Rhizobium loti Na+/H+ antiporter MLL3064 SWALL:Q98H22 (EMBL:AP003001) (517 aa) fasta scores: E(): 9.6e-31, 28.62% id in 531 aa; Na+/H+ antiporter 1193359 2649748 DIP1193 Corynebacterium diphtheriae NCTC 13129 Na+/H+ antiporter NP_939550.1 1191785 D 257309 CDS NP_939551.1 38233784 2649749 1193378..1193932 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical 25.3 kDa protein ML1369 or MLC1351.04C SWALL:O05669 (EMBL:Z95117) (231 aa) fasta scores: E(): 3.1e-33, 59.19% id in 174 aa, and to Bacillus halodurans BH1561 protein SWALL:Q9KCL0 (EMBL:AP001512) (197 aa) fasta scores: E(): 1.7e-13, 38.67% id in 181 aa; hypothetical protein 1193932 2649749 DIP1194 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939551.1 1193378 D 257309 CDS NP_939552.1 38233785 2649750 1194036..1195001 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 27.6 kDa protein Rv1711 or MT1751.1 or MTCI125.33 SWALL:YH11_MYCTU (SWALL:O33210) (254 aa) fasta scores: E(): 2.8e-52, 60.74% id in 242 aa, and to Bacillus subtilis ribosomal large subunit pseudouridine synthase B RluB SWALL:RLUB_BACSU (SWALL:P35159) (229 aa) fasta scores: E(): 2e-28, 46.72% id in 229 aa. Note: Alternative start codon at residue 55; pseudouridine synthase 1195001 2649750 DIP1195 Corynebacterium diphtheriae NCTC 13129 pseudouridine synthase NP_939552.1 1194036 D 257309 CDS NP_939553.1 38233786 2649751 1195003..1195728 1 NC_002935.2 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1195728 cmk 2649751 cmk Corynebacterium diphtheriae NCTC 13129 cytidylate kinase NP_939553.1 1195003 D 257309 CDS NP_939554.1 38233787 2649752 1195725..1197368 1 NC_002935.2 synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 1197368 engA 2649752 engA Corynebacterium diphtheriae NCTC 13129 GTP-binding protein EngA NP_939554.1 1195725 D 257309 CDS NP_939555.1 38233788 2649753 1197600..1198985 1 NC_002935.2 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter 1198985 dcuB 2649753 dcuB Corynebacterium diphtheriae NCTC 13129 anaerobic C4-dicarboxylate transporter NP_939555.1 1197600 D 257309 CDS NP_939556.1 38233789 2649754 complement(1199016..1200020) 1 NC_002935.2 Similar to, although longer in its N-terminal region than Mycobacterium tuberculosis methyltransferase Rv3342 or MT3445 or MTV016.42 SWALL:YX42_MYCTU (SWALL:O53392) (243 aa) fasta scores: E(): 2e-16, 31.71% id in 227 aa, and to Pseudomonas aeruginosa hypothetical protein PA0558 SWALL:Q9I5X8 (EMBL:AE004492) (255 aa) fasta scores: E(): 8.9e-11, 28.06% id in 253 aa; methyltransferase 1200020 2649754 DIP1199 Corynebacterium diphtheriae NCTC 13129 methyltransferase NP_939556.1 1199016 R 257309 CDS NP_939557.1 38233790 2649755 1200019..1201269 1 NC_002935.2 Similar to Corynebacterium glutamicum hypothetical 45.7 kDa protein in lysI 3'region SWALL:YLI2_CORGL (SWALL:P35866) (426 aa) fasta scores: E(): 4.7e-68, 46.93% id in 424 aa, and to Mycobacterium tuberculosis hypothetical 51.8 kDa protein Rv1639c or MTCY06H11.03c SWALL:P94973 (EMBL:Z85982) (489 aa) fasta scores: E(): 1.8e-16, 23.89% id in 385 aa; hypothetical protein 1201269 2649755 DIP1200 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939557.1 1200019 D 257309 CDS NP_939558.1 38233791 2649757 complement(1201642..1202019) 1 NC_002935.2 Similar to Streptomyces coelicolor conserved hypothetical protein SCI52.19 SWALL:Q9AD90 (EMBL:AL590507) (124 aa) fasta scores: E(): 2.7e-20, 49.58% id in 121 aa, and to Escherichia coli hypothetical protein YchJ or B1233 SWALL:YCHJ_ECOLI (SWALL:P37052) (152 aa) fasta scores: E(): 7.6e-15, 38.71% id in 124 aa; hypothetical protein 1202019 2649757 DIP1201 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939558.1 1201642 R 257309 CDS NP_939559.1 38233792 2649758 complement(1202026..1203213) 1 NC_002935.2 Similar to Rhizobium meliloti hypothetical protein RA1044 or SMA1898 SWALL:AAK65702 (EMBL:AE007290) (408 aa) fasta scores: E(): 8.8e-49, 39.34% id in 399 aa, and to Clostridium acetobutylicum alpha/beta superfamily hydrolase CAC3665 SWALL:AAK81587 (EMBL:AE007861) (265 aa) fasta scores: E(): 2.6e-07, 22.43% id in 263 aa; hypothetical protein 1203213 2649758 DIP1202 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939559.1 1202026 R 257309 CDS NP_939560.1 38233793 2649759 1203482..1205776 1 NC_002935.2 SecA2; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond to SecA2; which is non-essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 1205776 secA2 2649759 secA2 Corynebacterium diphtheriae NCTC 13129 preprotein translocase subunit SecA NP_939560.1 1203482 D 257309 CDS NP_939561.1 38233794 2649760 1205943..1206374 1 NC_002935.2 Similar to Mycobacterium smegmatis signal transduction protein GarA SWALL:Q9RP36 (EMBL:AF173844) (158 aa) fasta scores: E(): 6.6e-34, 68.21% id in 151 aa, and to Mycobacterium tuberculosis hypothetical 17.3 kDa protein Rv1827 or MT1875 or MTCY1A11.16c SWALL:YI27_MYCTU (SWALL:Q50606) (162 aa) fasta scores: E(): 3.7e-32, 67.83% id in 143 aa; signal transduction protein 1206374 2649760 DIP1204 Corynebacterium diphtheriae NCTC 13129 signal transduction protein NP_939561.1 1205943 D 257309 CDS NP_939562.1 38233795 2649761 1206545..1207222 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 26.5 kDa protein SC1A8A.03c SWALL:Q9KZP9 (EMBL:AL353861) (246 aa) fasta scores: E(): 1.4e-27, 41.44% id in 222 aa, and to Mycobacterium tuberculosis hypothetical 26.4 kDa protein Rv1828 or MT1876 or MTCY1A11.15c SWALL:YI28_MYCTU (SWALL:Q50605) (247 aa) fasta scores: E(): 1.2e-14, 40.25% id in 236 aa; MerR family transcriptional regulator 1207222 2649761 DIP1205 Corynebacterium diphtheriae NCTC 13129 MerR family transcriptional regulator NP_939562.1 1206545 D 257309 CDS NP_939563.1 38233796 2649762 1207245..1207832 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical 18.1 kDa protein ML2074 or MLCB1788.34c SWALL:O32917 (EMBL:AL008609) (164 aa) fasta scores: E(): 7.8e-13, 32.02% id in 153 aa, and to Mycobacterium tuberculosis hypothetical 18.1 kDa protein Rv1829 or MT1877 or MTCY1A11.14c SWALL:YI29_MYCTU (SWALL:Q50604) (164 aa) fasta scores: E(): 9.1e-13, 34.07% id in 135 aa; hypothetical protein 1207832 2649762 DIP1206 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939563.1 1207245 D 257309 CDS NP_939564.1 38233797 2649763 1207984..1208544 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 24.0 kDa protein Rv1830 or MT1879 or MTCY1A11.13c SWALL:YI30_MYCTU (SWALL:Q50603) (225 aa) fasta scores: E(): 1.5e-41, 72.98% id in 174 aa, and to Bacillus subtilis regulatory protein GlnR SWALL:GLNR_BACSU (SWALL:P37582) (135 aa) fasta scores: E(): 0.22, 29.16% id in 72 aa; transcriptional regulator 1208544 2649763 DIP1207 Corynebacterium diphtheriae NCTC 13129 transcriptional regulator NP_939564.1 1207984 D 257309 CDS NP_939565.1 38233798 2649764 complement(1208620..1210032) 1 NC_002935.2 hypothetical protein 1210032 2649764 DIP1208 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939565.1 1208620 R 257309 CDS NP_939566.1 38233799 2649765 complement(1210064..1210942) 1 NC_002935.2 Similar to Rhodococcus fascians hypothetical 34.0 kDa protein SWALL:Q9AE56 (EMBL:AJ301559) (304 aa) fasta scores: E(): 2.2e-46, 44.91% id in 285 aa; hypothetical protein 1210942 2649765 DIP1209 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939566.1 1210064 R 257309 CDS NP_939567.1 38233800 2649766 complement(1210939..1211991) 1 NC_002935.2 Similar to Rhodococcus fascians hypothetical 40.3 kDa protein SWALL:Q9AE57 (EMBL:AJ301559) (380 aa) fasta scores: E(): 5.4e-62, 50.28% id in 348 aa, to Streptomyces coelicolor integral membrane protein SC6D7.04 SWALL:Q9RKZ3 (EMBL:AL133213) (347 aa) fasta scores: E(): 8.2e-47, 40.93% id in 342 aa, and to Bacillus subtilis hypothetical 49.9 kDa protein in citA-sspB intergenic region YhdP SWALL:YHDP_BACSU (SWALL:O07585) (444 aa) fasta scores: E(): 5.3e-34, 34.48% id in 348 aa; hypothetical protein 1211991 2649766 DIP1210 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939567.1 1210939 R 257309 CDS NP_939568.1 38233801 2649767 complement(1211988..1213382) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 48.1 kDa protein Rv1842c or MT1890 or MTCY1A11.02 or MTCY359.31 SWALL:YI42_MYCTU (SWALL:Q50592) (455 aa) fasta scores: E(): 8.3e-77, 49.55% id in 444 aa, and to Myxococcus xanthus hemolysin TlyC SWALL:AAK64446 (EMBL:AF377339) (463 aa) fasta scores: E(): 9.4e-38, 34.74% id in 449 aa; hypothetical protein 1213382 2649767 DIP1211 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939568.1 1211988 R 257309 CDS NP_939569.1 38233802 2649768 complement(1213407..1214765) 1 NC_002935.2 Similar to Streptomyces coelicolor SC10A5.25c protein SWALL:O54116 (EMBL:AL021529) (498 aa) fasta scores: E(): 6.5e-63, 46.93% id in 424 aa, and to Escherichia coli ATP-dependent RNA helicase RhlE or B0797 SWALL:RHLE_ECOLI (SWALL:P25888) (454 aa) fasta scores: E(): 7.6e-44, 36.06% id in 452 aa; RNA helicase 1214765 2649768 DIP1212 Corynebacterium diphtheriae NCTC 13129 RNA helicase NP_939569.1 1213407 R 257309 CDS NP_939570.1 38233803 2649769 complement(1214868..1216322) 1 NC_002935.2 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 1216322 gnd 2649769 gnd Corynebacterium diphtheriae NCTC 13129 6-phosphogluconate dehydrogenase NP_939570.1 1214868 R 257309 CDS NP_939571.1 38233804 2649770 1216431..1216889 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 15.1 kDa protein Rv1847 or MT1895 or MTCY359.26c SWALL:YI47_MYCTU (SWALL:P95162) (140 aa) fasta scores: E(): 1.6e-08, 34.67% id in 124 aa, and to Pseudomonas aeruginosa hypothetical protein PA1618 SWALL:YG18_PSEAE (SWALL:Q9I3A4) (145 aa) fasta scores: E(): 2e-05, 32.82% id in 131 aa; hypothetical protein 1216889 2649770 DIP1214 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939571.1 1216431 D 257309 CDS NP_939572.1 38233805 2649771 complement(1216886..1217986) 1 NC_002935.2 Similar to Mycobacterium tuberculosis magnesium and cobalt transport protein CorA or Rv1239c or MT1277 or MTV006.11c SWALL:O50455 (EMBL:AL021006) (366 aa) fasta scores: E(): 1.9e-59, 43.45% id in 359 aa, and to Escherichia coli magnesium and cobalt transport protein CorA or B3816 or Z5333 or ECS4746 SWALL:CORA_ECOLI (SWALL:P27841) (316 aa) fasta scores: E(): 3e-05, 24.03% id in 312 aa; magnesium/cobalt transporter CorA 1217986 2649771 DIP1215 Corynebacterium diphtheriae NCTC 13129 magnesium/cobalt transporter CorA NP_939572.1 1216886 R 257309 CDS NP_939573.1 38233806 2649772 1217993..1218622 1 NC_002935.2 Low similarity to Agrobacterium tumefaciens StrC58 AGR_C_2998p SWALL:AAK87404 (EMBL:AE008084) (321 aa) fasta scores: E(): 2.8e-06, 31.33% id in 150 aa, and to Rhizobium meliloti hypothetical protein RB0059 or SMB20059 SWALL:CAC48459 (EMBL:AL603642) (259 aa) fasta scores: E(): 6.5e-05, 28.67% id in 143 aa; hypothetical protein 1218622 2649772 DIP1216 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939573.1 1217993 D 257309 CDS NP_939574.1 38233807 2649773 complement(1218699..1220063) 1 NC_002935.2 Similar to Corynebacterium glutamicum NADH dehydrogenase Ndh SWALL:Q9X710 (EMBL:AJ238250) (467 aa) fasta scores: E(): 2.7e-137, 78.71% id in 451 aa, and to Escherichia coli NADH dehydrogenase Ndh or B1109 SWALL:DHNA_ECOLI (SWALL:P00393) (433 aa) fasta scores: E(): 4.9e-20, 27.08% id in 443 aa; NADH dehydrogenase 1220063 ndh 2649773 ndh Corynebacterium diphtheriae NCTC 13129 NADH dehydrogenase NP_939574.1 1218699 R 257309 CDS NP_939575.1 38233808 2649774 1220241..1221536 1 NC_002935.2 Low similarity to Mycobacterium tuberculosis cyclopropane fatty acid synthase UfaA1 or Rv0447c or MT0463 or MTV037.11C SWALL:O53732 (EMBL:AL021932) (427 aa) fasta scores: E(): 2.2e-13, 27.14% id in 431 aa, and to Agrobacterium tumefaciens StrC58 AGR_C_3601p SWALL:AAK87737 (EMBL:AE008115) (410 aa) fasta scores: E(): 5.1e-06, 21.91% id in 356 aa; hypothetical protein 1221536 2649774 DIP1218 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939575.1 1220241 D 257309 CDS NP_939576.1 38233809 2649776 1222345..1223313 1 NC_002935.2 Similar to Salmonella typhimurium Na+-dependent transporter STM4195 SWALL:AAL23019 (EMBL:AE008896) (313 aa) fasta scores: E(): 8e-40, 41.43% id in 292 aa, and to Bacillus halodurans sodium-dependent transporter BH0858 SWALL:Q9KEJ4 (EMBL:AP001510) (323 aa) fasta scores: E(): 1.1e-38, 41.29% id in 293 aa; sodium-dependent transport membrane protein 1223313 2649776 DIP1221 Corynebacterium diphtheriae NCTC 13129 sodium-dependent transport membrane protein NP_939576.1 1222345 D 257309 CDS NP_939577.1 38233810 2649777 complement(1223713..1223895) 1 NC_002935.2 hypothetical protein 1223895 2649777 DIP1222 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939577.1 1223713 R 257309 CDS NP_939578.1 38233811 2649778 complement(1223913..1224611) 1 NC_002935.2 Low similarity to Xylella fastidiosa hypothetical protein XF1327 SWALL:Q9PDQ2 (EMBL:AE003965) (189 aa) fasta scores: E(): 0.14, 25.23% id in 210 aa, and to Streptomyces coelicolor hypothetical 28.6 kDa protein 2SC10A7.34c SWALL:Q9ADM8 (EMBL:AL583945) (273 aa) fasta scores: E(): 0.23, 25.11% id in 215 aa; hypothetical protein 1224611 2649778 DIP1223 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939578.1 1223913 R 257309 CDS NP_939579.1 38233812 2649779 complement(1224625..1224966) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 hypothetical 13.2 kDa protein MT2109 SWALL:AAK46388 (EMBL:AE007062) (120 aa) fasta scores: E(): 5e-15, 43.92% id in 107 aa; hypothetical protein 1224966 2649779 DIP1224 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939579.1 1224625 R 257309 CDS NP_939580.1 38233813 2649780 1225219..1225608 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 13.0 kDa protein Rv2050 or MTV018.37 SWALL:O53492 (EMBL:AL021899) (111 aa) fasta scores: E(): 6.5e-28, 70% id in 110 aa, and to Mycobacterium leprae hypothetical protein ML1439 SWALL:Q9CC05 (EMBL:AL583922) (111 aa) fasta scores: E(): 2.9e-27, 68.18% id in 110 aa; hypothetical protein 1225608 2649780 DIP1225 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939580.1 1225219 D 257309 CDS NP_939581.1 38233814 2649781 complement(1225684..1226487) 1 NC_002935.2 Similar to Mycobacterium smegmatis polyprenol phosphate mannosyl transferase 1 Ppm1 SWALL:Q9F408 (EMBL:AJ294477) (265 aa) fasta scores: E(): 1.6e-56, 61.6% id in 237 aa, and to Schizosaccharomyces pombe dolichol-phosphate mannosyltransferase Dpm1 or SPAC31G5.16c SWALL:O14466 (EMBL:AF007873) (236 aa) fasta scores: E(): 1.2e-24, 39.54% id in 220 aa; polyprenol phosphate mannosyl transferase 1 1226487 ppm1 2649781 ppm1 Corynebacterium diphtheriae NCTC 13129 polyprenol phosphate mannosyl transferase 1 NP_939581.1 1225684 R 257309 CDS NP_939582.1 38233815 2649782 complement(1226513..1228072) 1 NC_002935.2 Similar to Streptomyces coelicolor transferase 2SCG2.28c SWALL:Q9EX26 (EMBL:AL445963) (537 aa) fasta scores: E(): 2.4e-42, 37.71% id in 517 aa, and to Escherichia coli apolipoprotein N-acyltransferase Lnt or CutE or B0657 SWALL:LNT_ECOLI (SWALL:P23930) (512 aa) fasta scores: E(): 1.6e-19, 25.89% id in 533 aa; transferase/membrane protein 1228072 2649782 DIP1227 Corynebacterium diphtheriae NCTC 13129 transferase/membrane protein NP_939582.1 1226513 R 257309 CDS NP_939583.1 38233816 2649783 complement(1228082..1228612) 1 NC_002935.2 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein 1228612 fxsA 2649783 fxsA Corynebacterium diphtheriae NCTC 13129 FxsA protein NP_939583.1 1228082 R 257309 CDS NP_939584.1 38233817 2649784 complement(1228651..1232283) 1 NC_002935.2 with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism; cobaltochelatase subunit CobN 1232283 cobN 2649784 cobN Corynebacterium diphtheriae NCTC 13129 cobaltochelatase subunit CobN NP_939584.1 1228651 R 257309 CDS NP_939585.1 38233818 2649785 1232340..1232477 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 1232477 2649785 DIP1230 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939585.1 1232340 D 257309 CDS NP_939586.1 38233819 2649786 1232650..1233843 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 CobG-related protein MT2124 SWALL:AAK46404 (EMBL:AE007063) (363 aa) fasta scores: E(): 5.1e-43, 39.56% id in 369 aa; hypothetical protein 1233843 2649786 DIP1231 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939586.1 1232650 D 257309 CDS NP_939587.1 38233820 2649787 1233840..1234490 1 NC_002935.2 catalyzes the interconversion of precorrin-8X and hydrogenobyrinate; precorrin-8X methylmutase 1234490 cobH 2649787 cobH Corynebacterium diphtheriae NCTC 13129 precorrin-8X methylmutase NP_939587.1 1233840 D 257309 CDS NP_939588.1 38233821 2649788 1234487..1235983 1 NC_002935.2 Similar to Mycobacterium tuberculosis cobalamin biosynthesis protein [includes: precorrin-2 C20- methyltransferase; precorrin-3 methylase] CobIJ or Rv2066 or MT2126 or MTCY49.05 SWALL:COBI_MYCTU (SWALL:Q10677) (508 aa) fasta scores: E(): 3.6e-88, 50.7% id in 495 aa, C-terminal region to Rhodobacter capsulatus precorrin-3 methylase SWALL:O68097 (EMBL:AF010496) (245 aa) fasta scores: E(): 1.1e-34, 48.14% id in 243 aa, and N-terminal region to Pseudomonas aeruginosa precorrin-2 methyltransferase CobI or PA2904 SWALL:Q9HZU3 (EMBL:AE004716) (250 aa) fasta scores: E(): 1.4e-33, 43.3% id in 254 aa; bifunctional cobalamin biosynthesis protein 1235983 cobIJ 2649788 cobIJ Corynebacterium diphtheriae NCTC 13129 bifunctional cobalamin biosynthesis protein NP_939588.1 1234487 D 257309 CDS NP_939589.1 38233822 2649789 complement(1236065..1236796) 1 NC_002935.2 CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6; cobalt-precorrin-6x reductase 1236796 cobK 2649789 cobK Corynebacterium diphtheriae NCTC 13129 cobalt-precorrin-6x reductase NP_939589.1 1236065 R 257309 CDS NP_939590.1 38233823 2649790 complement(1236784..1237557) 1 NC_002935.2 Similar to Pseudomonas denitrificans precorrin-4 C11-methyltransferase CobM SWALL:COBM_PSEDE (SWALL:P21922) (253 aa) fasta scores: E(): 5.4e-46, 55.37% id in 251 aa, and to Rhodococcus erythropolis precorrin-4 C11-methyltransferase CobM SWALL:COBM_RHOER (SWALL:Q53138) (249 aa) fasta scores: E(): 3.4e-57, 61.04% id in 249 aa; precorrin-4 C(11)-methyltransferase 1237557 cobM 2649790 cobM Corynebacterium diphtheriae NCTC 13129 precorrin-4 C(11)-methyltransferase NP_939590.1 1236784 R 257309 CDS NP_939591.1 38233824 2649791 complement(1237585..1238832) 1 NC_002935.2 Similar to Mycobacterium tuberculosis precorrin-6Y C5,15-methyltransferase [decarboxylating] CobL or Rv2072c or MT2132 or MTCY49.11c SWALL:COBL_MYCTU (SWALL:Q10671) (390 aa) fasta scores: E(): 5.8e-57, 44.22% id in 398 aa, and to Pseudomonas denitrificans precorrin-6Y C5,15-methyltransferase [decarboxylating] CobL SWALL:COBL_PSEDE (SWALL:P21921) (413 aa) fasta scores: E(): 1.5e-47, 39.5% id in 405 aa; precorrin-6Y C5,15-methyltransferase 1238832 2649791 DIP1236 Corynebacterium diphtheriae NCTC 13129 precorrin-6Y C5,15-methyltransferase NP_939591.1 1237585 R 257309 CDS NP_939592.1 38233825 2649792 complement(1238888..1239652) 1 NC_002935.2 probable dehydrogenase; hypothetical protein 1239652 2649792 DIP1237 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939592.1 1238888 R 257309 CDS NP_939593.1 38233826 2649793 complement(1239661..1240800) 1 NC_002935.2 Similar to Mycobacterium tuberculosis probable dipeptidase Rv2089c or MT2150 or MTCY49.29c SWALL:YK89_MYCTU (SWALL:Q10698) (375 aa) fasta scores: E(): 3.1e-56, 49.86% id in 377 aa, and to Halobacterium sp probable peptidase PepQ1 or Vng0723g SWALL:Q9HRF6 (EMBL:AE005016) (369 aa) fasta scores: E(): 2.2e-37, 38.62% id in 378 aa; dipeptidase 1240800 2649793 DIP1238 Corynebacterium diphtheriae NCTC 13129 dipeptidase NP_939593.1 1239661 R 257309 CDS NP_939594.1 38233827 2649794 complement(1240851..1243643) 1 NC_002935.2 Similar to Mycobacterium tuberculosis probable helicase HelY or Rv2092c or MT2153 or MTCY49.30c SWALL:HELY_MYCTU (SWALL:Q10701) (906 aa) fasta scores: E(): 4.5e-69, 48.87% id in 933 aa, and to Synechocystis sp antiviral protein Ski2 or SLR0451 SWALL:P74686 (EMBL:D90917) (1006 aa) fasta scores: E(): 2.3e-27, 29.42% id in 1040 aa; helicase 1243643 2649794 DIP1239 Corynebacterium diphtheriae NCTC 13129 helicase NP_939594.1 1240851 R 257309 CDS NP_939595.1 38233828 2649795 1243744..1244214 1 NC_002935.2 Similar to Mycobacterium leprae tRNA/rRNA methyltransferase ML0419 SWALL:Q9CCU7 (EMBL:AL583918) (158 aa) fasta scores: E(): 7.7e-35, 58.71% id in 155 aa, and to Escherichia coli hypothetical tRNA/rRNA methyltransferase YibK or B3606 SWALL:YIBK_ECOLI (SWALL:P33899) (157 aa) fasta scores: E(): 3.3e-28, 50% id in 152 aa; tRNA/rRNA methyltransferase 1244214 2649795 DIP1240 Corynebacterium diphtheriae NCTC 13129 tRNA/rRNA methyltransferase NP_939595.1 1243744 D 257309 CDS NP_939596.1 38233829 2649796 complement(1244300..1245394) 1 NC_002935.2 Similar to, although longer in its C-terminal region than Mycobacterium tuberculosis Sec-independent protein translocase TatC homolog or Rv2093c or MT2154 or MTCY49.33c SWALL:TATC_MYCTU (SWALL:Q10702) (308 aa) fasta scores: E(): 1.6e-54, 56.55% id in 290 aa, and to Escherichia coli Sec-independent protein translocase TatC or MttB or B3839 or Z5360 or ECS4768 SWALL:TATC_ECOLI (SWALL:P27857) (258 aa) fasta scores: E(): 9.3e-14, 28.04% id in 271 aa; Sec-independent twin-arginine translocase system protein 1245394 tatC 2649796 tatC Corynebacterium diphtheriae NCTC 13129 Sec-independent twin-arginine translocase system protein NP_939596.1 1244300 R 257309 CDS NP_939597.1 38233830 2649797 complement(1245467..1245733) 1 NC_002935.2 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin-arginine translocation protein TatA 1245733 tatA 2649797 tatA Corynebacterium diphtheriae NCTC 13129 twin-arginine translocation protein TatA NP_939597.1 1245467 R 257309 CDS NP_939598.1 38233831 2649798 complement(1245768..1246727) 1 NC_002935.2 Similar to Rhodococcus erythropolis ORF11 SWALL:P72265 (EMBL:Z82004) (326 aa) fasta scores: E(): 1.3e-24, 31.42% id in 315 aa, and to Mycobacterium tuberculosis hypothetical 33.8 kDa protein Rv2095c precursor or MT2156 or MTCY49.35c SWALL:YK95_MYCTU (SWALL:Q10704) (316 aa) fasta scores: E(): 3.4e-24, 31.57% id in 304 aa; hypothetical protein 1246727 2649798 DIP1243 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939598.1 1245768 R 257309 CDS NP_939599.1 38233832 2649799 complement(1246792..1247769) 1 NC_002935.2 Similar to Rhodococcus erythropolis ORF10 SWALL:P72264 (EMBL:Z82004) (330 aa) fasta scores: E(): 6.6e-20, 31.42% id in 331 aa, and to Mycobacterium leprae hypothetical 35.4 kDa protein ML1329 or MLCB2533.25 or B2126_C3_266 SWALL:YK96_MYCLE (SWALL:P54076) (331 aa) fasta scores: E(): 2.8e-19, 30.42% id in 332 aa; hypothetical protein 1247769 2649799 DIP1244 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939599.1 1246792 R 257309 CDS NP_939600.1 38233833 2649800 complement(1247794..1249233) 1 NC_002935.2 Similar to Rhodococcus erythropolis ORF9 SWALL:P72270 (EMBL:Z82005) (447 aa) fasta scores: E(): 8.7e-96, 55.7% id in 456 aa, and to Mycobacterium tuberculosis hypothetical 51.4 kDa protein Rv2097c or MT2158 or MTCY49.37c SWALL:YK97_MYCTU (SWALL:Q10706) (452 aa) fasta scores: E(): 8.8e-96, 54.56% id in 460 aa; hypothetical protein 1249233 2649800 DIP1245 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939600.1 1247794 R 257309 CDS NP_939601.1 38233834 2649801 complement(1249238..1249432) 1 NC_002935.2 Similar to Mycobacterium smegmatis hypothetical 7.0 kDa protein PrcS SWALL:O30517 (EMBL:AF009645) (64 aa) fasta scores: E(): 3.2e-07, 60.71% id in 56 aa, and to Rhodococcus erythropolis similar to ORF7 SWALL:Q53082 (EMBL:U26422) (64 aa) fasta scores: E(): 1.6e-06, 55% id in 60 aa; hypothetical protein 1249432 2649801 DIP1246 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939601.1 1249238 R 257309 CDS NP_939602.1 38233835 2649802 complement(1249490..1251016) 1 NC_002935.2 Similar to Rhodococcus erythropolis similar to ORF6 SWALL:Q53081 (EMBL:U26422) (499 aa) fasta scores: E(): 2.2e-72, 48.04% id in 512 aa, and to Frankia spACN14A/ts-r. hypothetical 56.4 kDa protein SWALL:Q9RAW9 (EMBL:AF142435) (505 aa) fasta scores: E(): 3.8e-51, 47.36% id in 494 aa; hypothetical protein 1251016 2649802 DIP1247 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939602.1 1249490 R 257309 CDS NP_939603.1 38233836 2649803 complement(1251013..1252542) 1 NC_002935.2 Similar to, although shorter in its N-terminal region than Streptomyces coelicolor AAA protein family ATPase Arc SWALL:Q9RJ58 (EMBL:AL132648) (588 aa) fasta scores: E(): 3e-76, 54.14% id in 519 aa, and to, although shorter in its N-terminal region than Mycobacterium leprae AAA-family ATPase ML1316 or MLCB2533.12 or A2126A or B2126_C1_167 SWALL:YL15_MYCLE (SWALL:P46509) (609 aa) fasta scores: E(): 2.1e-58, 54.99% id in 531 aa; ATPase 1252542 2649803 DIP1248 Corynebacterium diphtheriae NCTC 13129 ATPase NP_939603.1 1251013 R 257309 CDS NP_939604.1 38233837 2649804 complement(1252639..1253475) 1 NC_002935.2 Similar to Rhodococcus erythropolis hypothetical 35.2 kDa protein SWALL:Q9ZG14 (EMBL:AF088800) (324 aa) fasta scores: E(): 7.9e-71, 65.45% id in 275 aa, and to Mycobacterium tuberculosis hypothetical 30.1 kDa protein Rv2118c or MTCY261.14c SWALL:O33253 (EMBL:Z97559) (280 aa) fasta scores: E(): 2.6e-62, 58.27% id in 278 aa; hypothetical protein 1253475 2649804 DIP1249 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939604.1 1252639 R 257309 CDS NP_939605.1 38233838 2649805 complement(1253482..1254840) 1 NC_002935.2 catalyzes the removal of amino acids from the N termini of peptides; aminopeptidase 1254840 2649805 DIP1250 Corynebacterium diphtheriae NCTC 13129 aminopeptidase NP_939605.1 1253482 R 257309 CDS NP_939606.1 38233839 2649806 1254942..1255808 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 30.9 kDa protein Rv2119 or MTCY261.15 SWALL:O33254 (EMBL:Z97559) (278 aa) fasta scores: E(): 9e-48, 48.16% id in 272 aa, and to Streptomyces coelicolor hypothetical 31.9 kDa protein SCI41.36 SWALL:Q9RJ55 (EMBL:AL132648) (284 aa) fasta scores: E(): 2.8e-45, 47.34% id in 264 aa; hypothetical protein 1255808 2649806 DIP1251 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939606.1 1254942 D 257309 CDS NP_939607.1 38233840 2649807 1255902..1256171 1 NC_002935.2 Low similarity to Caulobacter crescentus virulence-associated protein, CC2867 SWALL:Q9A4G7 (EMBL:AE005951) (104 aa) fasta scores: E(): 0.00032, 29.26% id in 82 aa, and to Bacteroides nodosus virulence-associated protein I VapI SWALL:VAPI_BACNO (SWALL:Q46560) (108 aa) fasta scores: E(): 0.0023, 27.58% id in 87 aa; virulence-associated protein 1256171 2649807 DIP1252 Corynebacterium diphtheriae NCTC 13129 virulence-associated protein NP_939607.1 1255902 D 257309 CDS NP_939608.1 38233841 2649808 complement(1256231..1257883) 1 NC_002935.2 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase 1257883 fhs 2649808 fhs Corynebacterium diphtheriae NCTC 13129 formate--tetrahydrofolate ligase NP_939608.1 1256231 R 257309 CDS NP_939609.1 38233842 2649809 complement(1258020..1259594) 1 NC_002935.2 catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 1259594 aspA 2649809 aspA Corynebacterium diphtheriae NCTC 13129 aspartate ammonia-lyase NP_939609.1 1258020 R 257309 CDS NP_939610.1 38233843 2649810 complement(1259869..1261176) 1 NC_002935.2 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 1261176 dcuA 2649810 dcuA Corynebacterium diphtheriae NCTC 13129 anaerobic C4-dicarboxylate transporter NP_939610.1 1259869 R 257309 CDS NP_939611.1 38233844 2649811 complement(1261537..1262382) 1 NC_002935.2 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 1262382 hisG 2649811 hisG Corynebacterium diphtheriae NCTC 13129 ATP phosphoribosyltransferase NP_939611.1 1261537 R 257309 CDS NP_939612.1 38233845 2650087 complement(1262464..1262727) 1 NC_002935.2 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; phosphoribosyl-ATP pyrophosphatase 1262727 hisE 2650087 hisE Corynebacterium diphtheriae NCTC 13129 phosphoribosyl-ATP pyrophosphatase NP_939612.1 1262464 R 257309 CDS NP_939613.1 38233846 2649812 complement(1262746..1263441) 1 NC_002935.2 Similar to Streptomyces coelicolor hydrolase SCI46.01c SWALL:Q9EWH4 (EMBL:AL499607) (233 aa) fasta scores: E(): 4.7e-15, 32.8% id in 189 aa, and to Rhodobacter capsulatus CbbY protein SWALL:CBBY_RHOCA (SWALL:O33513) (227 aa) fasta scores: E(): 1.6e-11, 33.65% id in 205 aa; hydrolase 1263441 2649812 DIP1258 Corynebacterium diphtheriae NCTC 13129 hydrolase NP_939613.1 1262746 R 257309 CDS NP_939614.1 38233847 2649813 complement(1263485..1267090) 1 NC_002935.2 Similar to Mycobacterium tuberculosis 5-methyltetrahydrofolate--homocysteine methyltransferase MetH or Rv2124c or MTCY261.20c SWALL:METH_MYCTU (SWALL:O33259) (1192 aa) fasta scores: E(): 0, 70.85% id in 1194 aa, and to Escherichia coli 5-methyltetrahydrofolate--homocysteine methyltransferase MetH or B4019 SWALL:METH_ECOLI (SWALL:P13009) (1226 aa) fasta scores: E(): 2.8e-92, 32.4% id in 1225 aa; 5-methyltetrahydrofolate--homocysteine methyltransferase 1267090 metH 2649813 metH Corynebacterium diphtheriae NCTC 13129 5-methyltetrahydrofolate--homocysteine methyltransferase NP_939614.1 1263485 R 257309 CDS NP_939615.1 38233848 2649814 complement(1267163..1267558) 1 NC_002935.2 Similar to the plasmid borne Corynebacterium striatum YtpA SWALL:Q9FB56 (EMBL:AF024666) (132 aa) fasta scores: E(): 7.6e-12, 37.19% id in 121 aa; hypothetical protein 1267558 2649814 DIP1260 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939615.1 1267163 R 257309 CDS NP_939616.1 38233849 2649815 complement(1267559..1268803) 1 NC_002935.2 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 1268803 cysS 2649815 cysS Corynebacterium diphtheriae NCTC 13129 cysteinyl-tRNA synthetase NP_939616.1 1267559 R 257309 CDS NP_939617.1 38233850 2649816 complement(1268849..1269697) 1 NC_002935.2 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 1269697 uppP 2649816 uppP Corynebacterium diphtheriae NCTC 13129 undecaprenyl pyrophosphate phosphatase NP_939617.1 1268849 R 257309 CDS NP_939618.1 38233851 2649817 1269829..1270878 1 NC_002935.2 Similar to Corynebacterium striatum LppL SWALL:Q9EVJ8 (EMBL:AF024666) (350 aa) fasta scores: E(): 4.3e-35, 34.21% id in 342 aa; lipoprotein 1270878 2649817 DIP1263 Corynebacterium diphtheriae NCTC 13129 lipoprotein NP_939618.1 1269829 D 257309 CDS NP_939619.1 38233852 2649818 1270943..1272034 1 NC_002935.2 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 1272034 pyrD 2649818 pyrD Corynebacterium diphtheriae NCTC 13129 dihydroorotate dehydrogenase 2 NP_939619.1 1270943 D 257309 CDS NP_939620.1 38233853 2649819 complement(1272452..1272991) 1 NC_002935.2 Similar to Corynebacterium striatum YbhB SWALL:Q9FB60 (EMBL:AF024666) (177 aa) fasta scores: E(): 5.1e-42, 60.67% id in 178 aa, and to Vibrio cholerae hypothetical protein VC1075 SWALL:Q9KT30 (EMBL:AE004189) (180 aa) fasta scores: E(): 1.2e-19, 41.1% id in 163 aa; hypothetical protein 1272991 2649819 DIP1265 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939620.1 1272452 R 257309 CDS NP_939621.1 38233854 2649821 1273380..1274759 1 NC_002935.2 Similar to, although shorter in its N-terminal region than Escherichia coli possible transposase of IS1353 YahA SWALL:Q9WTH9 (EMBL:AP000342) (514 aa) fasta scores: E(): 2.5e-62, 41.59% id in 464 aa, and similar to, although longer in its N-terminal region than Escherichia coli transposase InsK for insertion sequence element IS150 or B3558 SWALL:INSK_ECOLI (SWALL:P19769) (283 aa) fasta scores: E(): 2.6e-35, 38.62% id in 277 aa; transposase 1274759 2649821 DIP1266 Corynebacterium diphtheriae NCTC 13129 transposase NP_939621.1 1273380 D 257309 CDS NP_939622.1 38233855 2649823 complement(1276058..1276807) 1 NC_002935.2 Similar to, although sorter in its N-terminal region than Vibrio cholerae thiosulfate sulfurtransferase SseA, VCA0620 SWALL:Q9KLX1 (EMBL:AE004392) (276 aa) fasta scores: E(): 6.9e-30, 38.72% id in 235 aa, and than Escherichia coli O157:H7 3-mercaptopyruvate sulfurtransferase SseA or Z3788 or ECS3387 SWALL:AAG57635 (EMBL:AE005482) (334 aa) fasta scores: E(): 2e-27, 38.65% id in 238 aa. Note: In the database matches for this CDS, the non-catalitic domain lies in the N-terminal region of the protein, hence this CDS being shorter in that region should not suppose a change in the possible catalytic activity, mostly if we consider that the possibly active-site residue 204 (cysteine) lies within the almost conserved region (CGCGVTA in E. coli and CGSRVTA in C. diphtheriae) possibly responsible for substrate specificity; sulfurtransferase 1276807 2649823 DIP1270 Corynebacterium diphtheriae NCTC 13129 sulfurtransferase NP_939622.1 1276058 R 257309 CDS NP_939623.1 38233856 2649824 complement(1276921..1277925) 1 NC_002935.2 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 1277925 2649824 DIP1271 Corynebacterium diphtheriae NCTC 13129 arginine/ornithine transport system ATPase NP_939623.1 1276921 R 257309 CDS NP_939624.1 38233857 2649825 complement(1278111..1280318) 1 NC_002935.2 MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 1280318 sbm 2649825 sbm Corynebacterium diphtheriae NCTC 13129 methylmalonyl-CoA mutase NP_939624.1 1278111 R 257309 CDS NP_939625.1 38233858 2649826 complement(1280321..1282132) 1 NC_002935.2 Similar to Mycobacterium tuberculosis probable methylmalonyl-CoA mutase small subunit MutA or Rv1492 or MT1539 or MTCY277.14 SWALL:MUTA_MYCTU (SWALL:P71773) (615 aa) fasta scores: E(): 1.5e-69, 43.15% id in 621 aa, and to Porphyromonas gingivalis methylmalonyl-CoA mutase small subunit MutA or McmA SWALL:MUTA_PORGI (SWALL:Q59676) (617 aa) fasta scores: E(): 4.9e-31, 30.73% id in 628 aa; methylmalonyl-CoA mutase small subunit 1282132 2649826 DIP1273 Corynebacterium diphtheriae NCTC 13129 methylmalonyl-CoA mutase small subunit NP_939625.1 1280321 R 257309 CDS NP_939626.1 38233859 2649827 1282382..1283083 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 26.6 kDa protein Rv1491c or MT1538 or MTCY277.13c SWALL:YE91_MYCTU (SWALL:P71772) (252 aa) fasta scores: E(): 2.5e-24, 36.09% id in 205 aa, and to Streptomyces coelicolor integral membrane protein 2SCG61.05c SWALL:Q9K410 (EMBL:AL359949) (258 aa) fasta scores: E(): 2.3e-10, 28.09% id in 210 aa; hypothetical protein 1283083 2649827 DIP1274 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939626.1 1282382 D 257309 CDS NP_939627.1 38233860 2649828 1283144..1283710 1 NC_002935.2 DNA-binding protein 1283710 2649828 DIP1275 Corynebacterium diphtheriae NCTC 13129 DNA-binding protein NP_939627.1 1283144 D 257309 CDS NP_939628.1 38233861 2649829 complement(1283795..1284922) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 41.2 kDa protein Rv1488 or MT1533.2 or MTCY277.09 SWALL:YE88_MYCTU (SWALL:P71768) (381 aa) fasta scores: E(): 1.4e-79, 62.53% id in 363 aa, and to Pyrococcus abyssi stomatin-like protein PAB1324 SWALL:Q9UYE4 (EMBL:AJ248288) (299 aa) fasta scores: E(): 2.7e-35, 42.65% id in 279 aa; hypothetical protein 1284922 2649829 DIP1276 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939628.1 1283795 R 257309 CDS NP_939629.1 38233862 2649830 complement(1284919..1285353) 1 NC_002935.2 Similar to Mycobacterium avium MAV145 SWALL:O07404 (EMBL:AF002133) (145 aa) fasta scores: E(): 2.2e-11, 35.25% id in 139 aa, and to Streptomyces coelicolor integral membrane protein SC2H12.25 SWALL:Q9K459 (EMBL:AL359215) (146 aa) fasta scores: E(): 7.4e-11, 33.08% id in 136 aa; hypothetical protein 1285353 2649830 DIP1277 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939629.1 1284919 R 257309 CDS NP_939630.1 38233863 2649831 complement(1285420..1286262) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 29.4 kDa protein SCC77.24 SWALL:Q9RDD4 (EMBL:AL136503) (274 aa) fasta scores: E(): 1.3e-46, 50.57% id in 259 aa, and to Mycobacterium tuberculosis hypothetical 30.5 kDa protein Rv2033c or MTV018.20 SWALL:O53477 (EMBL:AL021899) (280 aa) fasta scores: E(): 6.7e-37, 46.78% id in 280 aa; hypothetical protein 1286262 2649831 DIP1278 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939630.1 1285420 R 257309 CDS NP_939631.1 38233864 2649832 1286298..1287083 1 NC_002935.2 hypothetical protein 1287083 2649832 DIP1279 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939631.1 1286298 D 257309 CDS NP_939632.1 38233865 2649833 complement(1287056..1288165) 1 NC_002935.2 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 1288165 hemH 2649833 hemH Corynebacterium diphtheriae NCTC 13129 ferrochelatase NP_939632.1 1287056 R 257309 CDS NP_939633.1 38233866 2649834 complement(1288281..1289999) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 49.8 kDa protein Rv1477 or MT1524 or MTV007.24 SWALL:O53168 (EMBL:AL021184) (472 aa) fasta scores: E(): 3.5e-21, 31.88% id in 577 aa, and C-terminal half similar to the whole length of Mycobacterium tuberculosis hypothetical invasion protein Inv1 SWALL:O33171 (EMBL:AF006054) (277 aa) fasta scores: E(): 1e-17, 39.5% id in 281 aa. Note: Contains two possible colied-coil region at residues 102..130 and 182..360; invasion protein 1289999 2649834 DIP1281 Corynebacterium diphtheriae NCTC 13129 invasion protein NP_939633.1 1288281 R 257309 CDS NP_939634.1 38233867 2649835 1290514..1290717 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 1290717 2649835 DIP1282 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939634.1 1290514 D 257309 CDS NP_939635.2 161598674 2649836 1290749..1293565 1 NC_002935.2 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1293565 acnA 2649836 acnA Corynebacterium diphtheriae NCTC 13129 aconitate hydratase NP_939635.2 1290749 D 257309 CDS NP_939636.1 38233869 2649837 1293673..1294245 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 transcriptional regulator, TetR family MT1521 SWALL:AAK45786 (EMBL:AE007021) (187 aa) fasta scores: E(): 1.8e-40, 60.42% id in 187 aa, and to Deinococcus radiodurans transcriptional regulator, TetR family DR2148 SWALL:Q9RSH6 (EMBL:AE002049) (204 aa) fasta scores: E(): 9e-06, 30.48% id in 164 aa; TetR family transcriptional regulator 1294245 2649837 DIP1284 Corynebacterium diphtheriae NCTC 13129 TetR family transcriptional regulator NP_939636.1 1293673 D 257309 CDS NP_939637.1 38233870 2649838 1294271..1294999 1 NC_002935.2 Catalyzes the transfer of the ammonia group from glutamine to a new carbon-nitrogen group; glutamine amidotransferase 1294999 2649838 DIP1285 Corynebacterium diphtheriae NCTC 13129 glutamine amidotransferase NP_939637.1 1294271 D 257309 CDS NP_939638.1 38233871 2649839 1295088..1295357 1 NC_002935.2 ACT domain-containing protein; hypothetical protein 1295357 2649839 DIP1286 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939638.1 1295088 D 257309 CDS NP_939639.1 38233872 2649840 1295374..1296738 1 NC_002935.2 Similar to Streptococcus pneumoniae hypothetical protein SP0239 SWALL:AAK74419 (EMBL:AE007336) (445 aa) fasta scores: E(): 8e-101, 65.91% id in 446 aa, and to Neisseria meningitidis hypothetical protein NMA1908 SWALL:Q9JTA4 (EMBL:AL162757) (451 aa) fasta scores: E(): 4.7e-98, 62.1% id in 446 aa; hypothetical protein 1296738 2649840 DIP1287 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939639.1 1295374 D 257309 CDS NP_939640.1 38233873 2649841 complement(1296797..1297045) 1 NC_002935.2 Similar to Bacillus subtilis hypothetical YxlE SWALL:P94373 (EMBL:D83026) (62 aa) fasta scores: E(): 0.028, 31.03% id in 58 aa; hypothetical protein 1297045 2649841 DIP1288 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939640.1 1296797 R 257309 CDS NP_939641.1 38233874 2649842 complement(1297069..1298700) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 ABC transporter, ATP-binding protein MT1519 SWALL:AAK45784 (EMBL:AE007021) (542 aa) fasta scores: E(): 2.2e-114, 70.95% id in 544 aa, and to Bacillus halodurans ABC transporter BH2025 SWALL:Q9KBA3 (EMBL:AP001514) (539 aa) fasta scores: E(): 6.5e-33, 32.07% id in 505 aa; ABC transporter ATP-binding protein 1298700 2649842 DIP1289 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_939641.1 1297069 R 257309 CDS NP_939642.1 38233875 2649843 complement(1298797..1299225) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 12.4 kDa protein Rv1466 or MTV007.13 SWALL:O53157 (EMBL:AL021184) (115 aa) fasta scores: E(): 6.7e-24, 67.3% id in 104 aa, and to Deinococcus radiodurans conserved hypothetical protein DR2165 SWALL:Q9RSF9 (EMBL:AE002050) (149 aa) fasta scores: E(): 1.1e-13, 43.59% id in 117 aa; hypothetical protein 1299225 2649843 DIP1290 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939642.1 1298797 R 257309 CDS NP_939643.1 38233876 2649844 complement(1299222..1299671) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 nitrogen fixation protein NifU-related protein MT1512 SWALL:AAK45776 (EMBL:AE007020) (162 aa) fasta scores: E(): 2.6e-35, 63.69% id in 146 aa, and to Bacillus subtilis NifU-like protein NifU SWALL:NIFU_BACSU (SWALL:O32163) (147 aa) fasta scores: E(): 3.7e-18, 44.21% id in 147 aa; nitrogen fixation protein NifU-like protein 1299671 2649844 DIP1291 Corynebacterium diphtheriae NCTC 13129 nitrogen fixation protein NifU-like protein NP_939643.1 1299222 R 257309 CDS NP_939644.1 38233877 2649845 complement(1299675..1300955) 1 NC_002935.2 Similar to Mycobacterium tuberculosis probable cysteine desulfurase Csd or Rv1464 or MT1511 or MTV007.11 SWALL:CSD_MYCTU (SWALL:O53155) (417 aa) fasta scores: E(): 1.4e-99, 63.81% id in 409 aa, and to Escherichia coli selenocysteine lyase CsdB or SufS or B1680 SWALL:CSDB_ECOLI (SWALL:P77444) (406 aa) fasta scores: E(): 1.4e-63, 41.7% id in 410 aa; cysteine desulfurase 1300955 csd 2649845 csd Corynebacterium diphtheriae NCTC 13129 cysteine desulfurase NP_939644.1 1299675 R 257309 CDS NP_939645.1 38233878 2649846 complement(1300955..1301713) 1 NC_002935.2 Similar to Streptomyces coelicolor ABC transporter ATP-binding subunit SCC22.04c SWALL:Q9XAD4 (EMBL:AL096839) (254 aa) fasta scores: E(): 4.3e-58, 70.4% id in 250 aa, and to Mycobacterium tuberculosis hypothetical 28.8 kDa protein Rv1463 or MTV007.10 SWALL:O53154 (EMBL:AL021184) (266 aa) fasta scores: E(): 8.8e-59, 70% id in 250 aa, and to Staphylococcus aureus (strain N315) SA0774 protein or SAV0842 SWALL:BAB57004 (EMBL:AP003131) (253 aa) fasta scores: E(): 1.7e-44, 58.63% id in 249 aa; ABC transporter ATP-binding protein 1301713 2649846 DIP1293 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_939645.1 1300955 R 257309 CDS NP_939646.1 38233879 2649847 complement(1301742..1302917) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 42.5 kDa protein Rv1462 or MT1509 or MTV007.09 SWALL:YE62_MYCTU (SWALL:O53153) (397 aa) fasta scores: E(): 7.7e-84, 56.05% id in 380 aa, and to Streptomyces coelicolor conserved hypothetical protein SCC22.06c SWALL:Q9XAD2 (EMBL:AL096839) (394 aa) fasta scores: E(): 6.1e-75, 52.86% id in 367 aa; hypothetical protein 1302917 2649847 DIP1294 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939646.1 1301742 R 257309 CDS NP_939647.1 38233880 2649848 complement(1302920..1304299) 1 NC_002935.2 Similar to Streptomyces coelicolor conserved hypothetical protein SCC22.07c SWALL:Q9XAD1 (EMBL:AL096839) (473 aa) fasta scores: E(): 1.9e-154, 82.78% id in 459 aa, and to Staphylococcus aureus (strain N315) hypothetical protein SA0778 or SAV0846 SWALL:Q99VF9 (EMBL:AP003131) (465 aa) fasta scores: E(): 1.7e-123, 65.14% id in 459 aa; hypothetical protein 1304299 2649848 DIP1295 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939647.1 1302920 R 257309 CDS NP_939648.1 38233881 2649849 complement(1304371..1305087) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 29.2 kDa protein Rv1460 or MTV007.07 SWALL:O53151 (EMBL:AL021184) (278 aa) fasta scores: E(): 3.4e-38, 46.25% id in 240 aa, and to Streptomyces coelicolor DNA-binding protein scc22.08C SWALL:Q9XAD0 (EMBL:AL096839) (252 aa) fasta scores: E(): 9e-27, 42.35% id in 229 aa; DNA-binding protein 1305087 2649849 DIP1296 Corynebacterium diphtheriae NCTC 13129 DNA-binding protein NP_939648.1 1304371 R 257309 CDS NP_939649.1 38233882 2649850 complement(1305304..1305666) 1 NC_002935.2 hypothetical protein 1305666 2649850 DIP1296A Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939649.1 1305304 R 257309 CDS NP_939650.1 38233883 2649851 1305862..1307424 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 62.7 kDa protein Rv1459c or MT1506 or MTV007.06c SWALL:AAK45770 (EMBL:AL021184) (591 aa) fasta scores: E(): 2.6e-33, 36.63% id in 546 aa, and to Mycobacterium tuberculosis membrane protein Rv2174 or MT2230 or MTV021.07 SWALL:O53508 (EMBL:AL021957) (516 aa) fasta scores: E(): 2.1e-18, 30.6% id in 464 aa, and low similarity to Rhizobium meliloti cytochrome C oxidase polypeptide I transmembrane protein CtaD or R00905 or SMC00010 SWALL:Q92RG9 (EMBL:AL591785) (562 aa) fasta scores: E(): 1.6, 22.94% id in 475 aa; hypothetical protein 1307424 2649851 DIP1297 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939650.1 1305862 D 257309 CDS NP_939651.1 38233884 2649852 1307491..1308402 1 NC_002935.2 Similar to Mycobacterium tuberculosis ABC-transporter ATP-binding protein Rv1458c or MTV007.05c SWALL:O53149 (EMBL:AL021184) (313 aa) fasta scores: E(): 2e-48, 50.32% id in 304 aa, and to Streptomyces peucetius daunorubicin resistance ATP-binding protein DrrA SWALL:DRRA_STRPE (SWALL:P32010) (330 aa) fasta scores: E(): 1.5e-24, 34.09% id in 305 aa; ABC transporter ATP-binding protein 1308402 2649852 DIP1298 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_939651.1 1307491 D 257309 CDS NP_939652.1 38233885 2649853 1308405..1309202 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 27.4 kDa protein Rv1457c or MTV007.04c SWALL:O86349 (EMBL:AL021184) (261 aa) fasta scores: E(): 1.5e-31, 41.47% id in 258 aa, and to Mycobacterium smegmatis hypothetical 24.4 kDa protein SWALL:O87317 (EMBL:AF027770) (236 aa) fasta scores: E(): 1.1e-23, 37.55% id in 237 aa; hypothetical protein 1309202 2649853 DIP1299 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939652.1 1308405 D 257309 CDS NP_939653.1 38233886 2649854 1309283..1310221 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 32.4 kDa protein Rv1456c or MT1503 or MTV007.03C SWALL:AAK45767 (EMBL:AL021184) (311 aa) fasta scores: E(): 3.7e-43, 43.75% id in 304 aa, and to Streptomyces coelicolor integral membrane transport protein SCC22.12 SWALL:Q9XAC6 (EMBL:AL096839) (356 aa) fasta scores: E(): 6.9e-24, 33.01% id in 312 aa, and low similarity to Bacillus firmus cytochrome aa3 controlling protein ctaA SWALL:CTAA_BACFI (SWALL:Q04443) (297 aa) fasta scores: E(): 0.0021, 21.42% id in 266 aa; hypothetical protein 1310221 2649854 DIP1300 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939653.1 1309283 D 257309 CDS NP_939654.1 38233887 2649855 complement(1310339..1311271) 1 NC_002935.2 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 1311271 2649855 DIP1301 Corynebacterium diphtheriae NCTC 13129 protoheme IX farnesyltransferase NP_939654.1 1310339 R 257309 CDS NP_939655.1 38233888 2649856 1311649..1313751 1 NC_002935.2 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1313751 tkt 2649856 tkt Corynebacterium diphtheriae NCTC 13129 transketolase NP_939655.1 1311649 D 257309 CDS NP_939656.1 38233889 2649857 1313875..1314957 1 NC_002935.2 catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate; transaldolase 1314957 tal 2649857 tal Corynebacterium diphtheriae NCTC 13129 transaldolase NP_939656.1 1313875 D 257309 CDS NP_939657.1 38233890 2649858 1315019..1316668 1 NC_002935.2 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1316668 zwf 2649858 zwf Corynebacterium diphtheriae NCTC 13129 glucose-6-phosphate 1-dehydrogenase NP_939657.1 1315019 D 257309 CDS NP_939658.1 38233891 2649859 1316693..1317652 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 37.7 kDa protein SCC22.20 SWALL:Q9XAB8 (EMBL:AL096839) (351 aa) fasta scores: E(): 1.5e-36, 41.82% id in 318 aa, and to Mycobacterium tuberculosis hypothetical 32.7 kDa protein OpcA or Rv1446c or MT1493 or MTCY493.08 SWALL:AAK45756 (EMBL:Z95844) (303 aa) fasta scores: E(): 9.5e-35, 39.3% id in 318 aa; hypothetical protein 1317652 2649859 DIP1305 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939658.1 1316693 D 257309 CDS NP_939659.1 38233892 2649860 1317678..1318394 1 NC_002935.2 catalyzes the formation of 6-phospho-D-gluconate from 6-phospho-D-glucono-1,5-lactone; 6-phosphogluconolactonase 1318394 2649860 DIP1306 Corynebacterium diphtheriae NCTC 13129 6-phosphogluconolactonase NP_939659.1 1317678 D 257309 CDS NP_939660.1 38233893 2649861 complement(1318462..1318695) 1 NC_002935.2 Similar to Corynebacterium glutamicum protein-export membrane protein SecG SWALL:SECG_CORGL (SWALL:Q9Z469) (77 aa) fasta scores: E(): 7.3e-22, 82.89% id in 76 aa, and to Escherichia coli protein-export membrane protein SecG or B3175 or Z4537 or ECS4054 SWALL:SECG_ECOLI (SWALL:P33582) (110 aa) fasta scores: E(): 0.55, 26.02% id in 73 aa; preprotein translocase subunit SecG 1318695 secG 2649861 secG Corynebacterium diphtheriae NCTC 13129 preprotein translocase subunit SecG NP_939660.1 1318462 R 257309 CDS NP_939661.1 38233894 2649862 complement(1318869..1319651) 1 NC_002935.2 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 1319651 tpiA 2649862 tpiA Corynebacterium diphtheriae NCTC 13129 triosephosphate isomerase NP_939661.1 1318869 R 257309 CDS NP_939662.1 38233895 2649863 complement(1319763..1320980) 1 NC_002935.2 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 1320980 pgk 2649863 pgk Corynebacterium diphtheriae NCTC 13129 phosphoglycerate kinase NP_939662.1 1319763 R 257309 CDS NP_939663.1 38233896 2649864 complement(1321111..1322115) 1 NC_002935.2 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; glyceraldehyde-3-phosphate dehydrogenase 1322115 gap 2649864 gap Corynebacterium diphtheriae NCTC 13129 glyceraldehyde-3-phosphate dehydrogenase NP_939663.1 1321111 R 257309 CDS NP_939664.1 38233897 2649865 complement(1322488..1323474) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 34.9 kDa protein CY21B4.41 Rv1423 or MT1466 or MTCY21B4.41 or MTCY493.31c SWALL:AAK45731 (EMBL:Z80108) (327 aa) fasta scores: E(): 4.2e-71, 61.84% id in 325 aa, and to Streptomyces coelicolor WhiA SWALL:Q9S4Y1 (EMBL:AF106003) (330 aa) fasta scores: E(): 3.7e-67, 57.53% id in 325 aa; hypothetical protein 1323474 2649865 DIP1311 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939664.1 1322488 R 257309 CDS NP_939665.1 38233898 2649866 complement(1323568..1324539) 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical protein ML0564 SWALL:Q9CCN9 (EMBL:AL583918) (359 aa) fasta scores: E(): 2.7e-63, 57.6% id in 309 aa, and to Escherichia coli hypothetical protein YbhK or B0780 SWALL:YBHK_ECOLI (SWALL:P75767) (302 aa) fasta scores: E(): 1.5e-11, 31.95% id in 291 aa; hypothetical protein 1324539 2649866 DIP1312 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939665.1 1323568 R 257309 CDS NP_939666.1 38233899 2649867 complement(1324558..1325457) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 32.9 kDa protein Rv1421 or MT1464 or MTCY21B4.39 SWALL:YE21_MYCTU (SWALL:P71690) (301 aa) fasta scores: E(): 9e-52, 47.82% id in 299 aa, and to Clostridium acetobutylicum predicted P-loop containing kinase, similar to B.subtilis YvcJ CAC0511 SWALL:AAK78491 (EMBL:AE007566) (294 aa) fasta scores: E(): 4.8e-43, 44.21% id in 285 aa; hypothetical protein 1325457 2649867 DIP1313 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939666.1 1324558 R 257309 CDS NP_939667.1 38233900 2649868 complement(1325463..1327526) 1 NC_002935.2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1327526 uvrC 2649868 uvrC Corynebacterium diphtheriae NCTC 13129 excinuclease ABC subunit C NP_939667.1 1325463 R 257309 CDS NP_939668.1 38233901 2649869 complement(1327536..1328096) 1 NC_002935.2 Similar to Corynebacterium ammoniagenes RibX protein SWALL:O24754 (EMBL:AB003693) (184 aa) fasta scores: E(): 1.3e-34, 45.98% id in 187 aa, and to Mycobacterium leprae membrane protein ML0561 SWALL:Q9CCP2 (EMBL:AL583918) (156 aa) fasta scores: E(): 2.3e-15, 37.58% id in 141 aa; hypothetical protein 1328096 2649869 DIP1315 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939668.1 1327536 R 257309 CDS NP_939669.1 38233902 2649870 complement(1328235..1328702) 1 NC_002935.2 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 1328702 ribH 2649870 ribH Corynebacterium diphtheriae NCTC 13129 6,7-dimethyl-8-ribityllumazine synthase NP_939669.1 1328235 R 257309 CDS NP_939670.1 38233903 2649871 complement(1328703..1329941) 1 NC_002935.2 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II 1329941 ribA 2649871 ribA Corynebacterium diphtheriae NCTC 13129 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II NP_939670.1 1328703 R 257309 CDS NP_939671.1 38233904 2649872 complement(1330056..1330664) 1 NC_002935.2 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1330664 ribE 2649872 ribE Corynebacterium diphtheriae NCTC 13129 riboflavin synthase subunit alpha NP_939671.1 1330056 R 257309 CDS NP_939672.1 38233905 2649873 complement(1330722..1331726) 1 NC_002935.2 Similar to Corynebacterium ammoniagenes riboflavin biosynthesis protein [includes: riboflavin-specific deaminase and uracil reductase] RibD or RibG SWALL:RIBD_CORAM (SWALL:O24750) (337 aa) fasta scores: E(): 4.7e-50, 46.89% id in 322 aa, and to Bacillus subtilis riboflavin biosynthesis protein RibD or RibG SWALL:RIBD_BACSU (SWALL:P17618) (361 aa) fasta scores: E(): 2.8e-22, 34.76% id in 325 aa; riboflavin biosynthesis protein 1331726 ribD 2649873 ribD Corynebacterium diphtheriae NCTC 13129 riboflavin biosynthesis protein NP_939672.1 1330722 R 257309 CDS NP_939673.1 38233906 2649874 complement(1331821..1332495) 1 NC_002935.2 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 1332495 rpe 2649874 rpe Corynebacterium diphtheriae NCTC 13129 ribulose-phosphate 3-epimerase NP_939673.1 1331821 R 257309 CDS NP_939674.1 38233907 2649875 complement(1332549..1334006) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 48.5 kDa protein Rv1407 or MT1451 or MTCY21B4.24 SWALL:YE07_MYCTU (SWALL:P71675) (457 aa) fasta scores: E(): 6.2e-86, 55.4% id in 453 aa, and to Escherichia coli Sun protein Sun or Fmu or Fmv or RsmB or B3289 SWALL:SUN_ECOLI (SWALL:P36929) (429 aa) fasta scores: E(): 1.2e-31, 33.63% id in 449 aa; hypothetical protein 1334006 2649875 DIP1321 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939674.1 1332549 R 257309 CDS NP_939675.1 38233908 2649876 complement(1334003..1334938) 1 NC_002935.2 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 1334938 fmt 2649876 fmt Corynebacterium diphtheriae NCTC 13129 methionyl-tRNA formyltransferase NP_939675.1 1334003 R 257309 CDS NP_939676.1 38233909 2649877 complement(1334975..1335484) 1 NC_002935.2 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1335484 def 2649877 def Corynebacterium diphtheriae NCTC 13129 peptide deformylase NP_939676.1 1334975 R 257309 CDS NP_939677.1 38233910 2649878 complement(1335564..1337591) 1 NC_002935.2 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 1337591 2649878 DIP1324 Corynebacterium diphtheriae NCTC 13129 primosome assembly protein PriA NP_939677.1 1335564 R 257309 CDS NP_939678.1 38233911 2649879 complement(1337610..1338842) 1 NC_002935.2 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1338842 metK 2649879 metK Corynebacterium diphtheriae NCTC 13129 S-adenosylmethionine synthetase NP_939678.1 1337610 R 257309 CDS NP_939679.1 38233912 2649880 complement(1338983..1340227) 1 NC_002935.2 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 1340227 dfp 2649880 dfp Corynebacterium diphtheriae NCTC 13129 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase NP_939679.1 1338983 R 257309 CDS NP_939680.1 38233913 2649881 complement(1340329..1340607) 1 NC_002935.2 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 1340607 rpoZ 2649881 rpoZ Corynebacterium diphtheriae NCTC 13129 DNA-directed RNA polymerase subunit omega NP_939680.1 1340329 R 257309 CDS NP_939681.1 38233914 2649882 complement(1340681..1341256) 1 NC_002935.2 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1341256 gmk 2649882 gmk Corynebacterium diphtheriae NCTC 13129 guanylate kinase NP_939681.1 1340681 R 257309 CDS NP_939682.1 38233915 2649883 complement(1341260..1341583) 1 NC_002935.2 Similar to Mycobacterium smegmatis integration host factor MihF SWALL:P96802 (EMBL:U75344) (105 aa) fasta scores: E(): 7.1e-21, 72.38% id in 105 aa, and to Mycobacterium tuberculosis hypothetical 20.8 kDa protein CY21B4.05 Rv1388 or MT1433 or MTCY21B4.05 SWALL:AAK45698 (EMBL:Z80108) (111 aa) fasta scores: E(): 3.8e-21, 74.75% id in 103 aa; integration host factor 1341583 mihF 2649883 mihF Corynebacterium diphtheriae NCTC 13129 integration host factor NP_939682.1 1341260 R 257309 CDS NP_939683.1 38233916 2649884 complement(1341932..1342780) 1 NC_002935.2 OMP decarboxylase; OMPDCase; OMPdecase; type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1342780 pyrF 2649884 pyrF Corynebacterium diphtheriae NCTC 13129 orotidine 5'-phosphate decarboxylase NP_939683.1 1341932 R 257309 CDS NP_939684.1 38233917 2649885 complement(1342777..1346133) 1 NC_002935.2 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 1346133 carB 2649885 carB Corynebacterium diphtheriae NCTC 13129 carbamoyl phosphate synthase large subunit NP_939684.1 1342777 R 257309 CDS NP_939685.1 38233918 2649886 complement(1346154..1347293) 1 NC_002935.2 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 1347293 carA 2649886 carA Corynebacterium diphtheriae NCTC 13129 carbamoyl phosphate synthase small subunit NP_939685.1 1346154 R 257309 CDS NP_939686.1 38233919 2649887 complement(1347449..1348795) 1 NC_002935.2 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1348795 pyrC 2649887 pyrC Corynebacterium diphtheriae NCTC 13129 dihydroorotase NP_939686.1 1347449 R 257309 CDS NP_939687.1 38233920 2648777 complement(1348820..1349761) 1 NC_002935.2 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 1349761 pyrB 2648777 pyrB Corynebacterium diphtheriae NCTC 13129 aspartate carbamoyltransferase NP_939687.1 1348820 R 257309 CDS NP_939688.1 38233921 2648778 complement(1349761..1350333) 1 NC_002935.2 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 1350333 pyrR 2648778 pyrR Corynebacterium diphtheriae NCTC 13129 bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase NP_939688.1 1349761 R 257309 CDS NP_939689.1 38233922 2648779 1350598..1351959 1 NC_002935.2 C-terminal region similar to Mycobacterium tuberculosis hypothetical 31.7 kDa protein Rv2216 or MT2273 or MTCY190.27 SWALL:YM16_MYCTU (SWALL:Q10403) (301 aa) fasta scores: E(): 4e-32, 36.51% id in 293 aa, and N-terminal region to Bacillus halodurans BH1480 protein SWALL:Q9KCT9 (EMBL:AP001512) (144 aa) fasta scores: E(): 0.047, 27.35% id in 106 aa; hypothetical protein 1351959 2648779 DIP1336 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939689.1 1350598 D 257309 CDS NP_939690.1 38233923 2648780 1351965..1352402 1 NC_002935.2 hypothetical protein 1352402 2648780 DIP1337 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939690.1 1351965 D 257309 CDS NP_939691.1 38233924 2648781 1352402..1352812 1 NC_002935.2 hypothetical protein 1352812 2648781 DIP1338 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939691.1 1352402 D 257309 CDS NP_939692.1 38233925 2648782 complement(1352866..1353414) 1 NC_002935.2 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 1353414 nusB 2648782 nusB Corynebacterium diphtheriae NCTC 13129 transcription antitermination protein NusB NP_939692.1 1352866 R 257309 CDS NP_939693.1 38233926 2648783 complement(1353483..1354046) 1 NC_002935.2 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 1354046 efp 2648783 efp Corynebacterium diphtheriae NCTC 13129 elongation factor P NP_939693.1 1353483 R 257309 CDS NP_939694.1 38233927 2648784 complement(1354148..1355245) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 38.8 kDa protein PepQ or Rv2535c or MTCY159.21 SWALL:P95018 (EMBL:Z83863) (372 aa) fasta scores: E(): 2.3e-52, 45.64% id in 344 aa, and to Bacillus halodurans xaa-pro dipeptidase BH2800 SWALL:Q9K950 (EMBL:AP001516) (355 aa) fasta scores: E(): 1.2e-43, 41.57% id in 356 aa; metallopeptidase 1355245 2648784 DIP1341 Corynebacterium diphtheriae NCTC 13129 metallopeptidase NP_939694.1 1354148 R 257309 CDS NP_939695.1 38233928 2648785 complement(1355271..1355711) 1 NC_002935.2 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 1355711 aroQ 2648785 aroQ Corynebacterium diphtheriae NCTC 13129 3-dehydroquinate dehydratase NP_939695.1 1355271 R 257309 CDS NP_939696.1 38233929 2648786 complement(1355712..1356791) 1 NC_002935.2 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 1356791 aroB 2648786 aroB Corynebacterium diphtheriae NCTC 13129 3-dehydroquinate synthase NP_939696.1 1355712 R 257309 CDS NP_939697.1 38233930 2648787 complement(1356838..1357359) 1 NC_002935.2 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 1357359 aroK 2648787 aroK Corynebacterium diphtheriae NCTC 13129 shikimate kinase NP_939697.1 1356838 R 257309 CDS NP_939698.1 38233931 2648788 complement(1357394..1358605) 1 NC_002935.2 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 1358605 aroC 2648788 aroC Corynebacterium diphtheriae NCTC 13129 chorismate synthase NP_939698.1 1357394 R 257309 CDS NP_939699.1 38233932 2648789 complement(1358683..>1359189) 1 NC_002935.2 Similar to the C-terminal region of Aeromonas salmonicida type 4 prepilin-like proteins leader peptide processing enzyme [includes: leader peptidase TapD or PilD] SWALL:LEP4_AERSA (SWALL:O68964) (291 aa) fasta scores: E(): 0.012, 26.71% id in 146 aa; hypothetical protein >1359189 2648789 DIP1346 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939699.1 1358683 R 257309 CDS NP_939700.1 38233933 2648790 complement(1359196..1360065) 1 NC_002935.2 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 1360065 aroE 2648790 aroE Corynebacterium diphtheriae NCTC 13129 shikimate 5-dehydrogenase NP_939700.1 1359196 R 257309 CDS NP_939701.1 38233934 2648791 complement(1360160..1361308) 1 NC_002935.2 Similar to, although shorter in its N-terminal region than Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT2630 SWALL:AAK46942 (EMBL:AE007097) (417 aa) fasta scores: E(): 2.3e-52, 41.38% id in 389 aa, and similar to Haemophilus influenzae hypothetical protein HI0457 SWALL:YCEG_HAEIN (SWALL:P44720) (347 aa) fasta scores: E(): 7.2e-14, 28.76% id in 365 aa; hypothetical protein 1361308 2648791 DIP1348 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939701.1 1360160 R 257309 CDS NP_939702.1 38233935 2648792 complement(1361421..1361972) 1 NC_002935.2 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 1361972 2648792 DIP1349 Corynebacterium diphtheriae NCTC 13129 Holliday junction resolvase-like protein NP_939702.1 1361421 R 257309 CDS NP_939703.1 38233936 2648793 complement(1362202..1364868) 1 NC_002935.2 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1364868 alaS 2648793 alaS Corynebacterium diphtheriae NCTC 13129 alanyl-tRNA synthetase NP_939703.1 1362202 R 257309 CDS NP_939704.1 38233937 2648794 complement(1365030..1366400) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 47.5 kDa protein Rv2559c or MT2636 or MTCY9C4.09 SWALL:YP59_MYCTU (SWALL:Q50739) (452 aa) fasta scores: E(): 3.1e-95, 66.59% id in 455 aa, and to Streptomyces coelicolor conserved ATP/GTP binding protein SC9C5.30c SWALL:Q9KXP4 (EMBL:AL357523) (451 aa) fasta scores: E(): 4.3e-84, 63.52% id in 414 aa; recombination factor protein RarA 1366400 2648794 DIP1351 Corynebacterium diphtheriae NCTC 13129 recombination factor protein RarA NP_939704.1 1365030 R 257309 CDS NP_939705.1 38233938 2648795 complement(1366425..1367687) 1 NC_002935.2 hypothetical protein 1367687 2648795 DIP1352 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939705.1 1366425 R 257309 CDS NP_939706.1 38233939 2648796 complement(1367810..1369615) 1 NC_002935.2 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 1369615 aspS 2648796 aspS Corynebacterium diphtheriae NCTC 13129 aspartyl-tRNA synthetase NP_939706.1 1367810 R 257309 CDS NP_939707.1 38233940 2648797 1369837..1370721 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 30.8 kDa protein Rv2575 or MT2651 or MTCY227.26c SWALL:YP75_MYCTU (SWALL:Q50646) (293 aa) fasta scores: E(): 1.8e-45, 44.74% id in 295 aa, and to Agrobacterium tumefaciens strC58 AGR_C_3948p SWALL:AAK87920 (EMBL:AE008134) (305 aa) fasta scores: E(): 1.1e-31, 36.66% id in 300 aa; hypothetical protein 1370721 2648797 DIP1354 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939707.1 1369837 D 257309 CDS NP_939708.1 38233941 2648798 complement(1370802..1373456) 1 NC_002935.2 Similar to Streptomyces coelicolor bifunctional protein SCBAC20F6.07 SWALL:Q9ADE3 (EMBL:AL590942) (800 aa) fasta scores: E(): 5e-37, 39% id in 700 aa, and to Streptomyces griseus hypothetical 77.7 kDa protein SWALL:BAB64333 (EMBL:AB056583) (724 aa) fasta scores: E(): 2.5e-32, 34.85% id in 680 aa; hypothetical protein 1373456 2648798 DIP1355 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939708.1 1370802 R 257309 CDS NP_939709.1 38233942 2648799 complement(1373535..1375556) 1 NC_002935.2 Similar to Bacillus subtilis hypothetical 84.1 kDa protein in hemY-gltT intergenic region YhgE SWALL:YHGE_BACSU (SWALL:P32399) (775 aa) fasta scores: E(): 5.1e-22, 25.23% id in 761 aa, and to Lactococcus lactis hypothetical protein YjaE or LL0882 SWALL:Q9CH57 (EMBL:AE006322) (799 aa) fasta scores: E(): 6.5e-20, 24.68% id in 790 aa; hypothetical protein 1375556 2648799 DIP1356 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939709.1 1373535 R 257309 CDS NP_939710.1 38233943 2649888 complement(1375574..1376308) 1 NC_002935.2 hypothetical protein 1376308 2649888 DIP1357 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939710.1 1375574 R 257309 CDS NP_939711.1 38233944 2649889 1376471..1377061 1 NC_002935.2 Similar to Streptomyces coelicolor TetR family transcriptional regulator SCF6.16 SWALL:Q9RJL5 (EMBL:AL121849) (194 aa) fasta scores: E(): 6.8e-06, 25.53% id in 188 aa, and to Rhizobium loti probable transcription regulator MLL1924 SWALL:Q98JI8 (EMBL:AP002998) (205 aa) fasta scores: E(): 1.1e-05, 25.77% id in 194 aa; TetR family transcriptional regulator 1377061 2649889 DIP1358 Corynebacterium diphtheriae NCTC 13129 TetR family transcriptional regulator NP_939711.1 1376471 D 257309 CDS NP_939712.1 38233945 2649890 1377106..1378494 1 NC_002935.2 Similar to Pseudomonas aeruginosa L-serine dehydratase SdaB or PA5379 SWALL:Q9HTI5 (EMBL:AE004950) (458 aa) fasta scores: E(): 3.5e-84, 53.99% id in 463 aa, and to Escherichia coli L-serine dehydratase 1 SdaA or B1814 SWALL:SDHL_ECOLI (SWALL:P16095) (454 aa) fasta scores: E(): 3e-70, 49.24% id in 461 aa; L-serine dehydratase 1378494 sdaB 2649890 sdaB Corynebacterium diphtheriae NCTC 13129 L-serine dehydratase NP_939712.1 1377106 D 257309 CDS NP_939713.1 38233946 2649891 complement(1378566..1379837) 1 NC_002935.2 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 1379837 hisS 2649891 hisS Corynebacterium diphtheriae NCTC 13129 histidyl-tRNA synthetase NP_939713.1 1378566 R 257309 CDS NP_939714.1 38233947 2649892 complement(1379878..1380534) 1 NC_002935.2 Similar to Streptomyces coelicolor possible hydrolase SC9C5.33c SWALL:Q9KXP1 (EMBL:AL357523) (235 aa) fasta scores: E(): 6.5e-25, 40.35% id in 223 aa, and to Escherichia coli hypothetical protein YcbL or B0927 SWALL:YCBL_ECOLI (SWALL:P75849) (215 aa) fasta scores: E(): 3.7e-23, 36.79% id in 212 aa; hypothetical protein 1380534 2649892 DIP1361 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939714.1 1379878 R 257309 CDS NP_939715.1 38233948 2649893 complement(1380544..1381041) 1 NC_002935.2 Similar to Escherichia coli thiol peroxidase Tpx or B1324 or Z2452 or ECS1903 SWALL:TPX_ECOLI (SWALL:P37901) (167 aa) fasta scores: E(): 5.8e-35, 61.11% id in 162 aa, and to Pseudomonas aeruginosa probable thiol peroxidase Tpx or PA2532 SWALL:TPX_PSEAE (SWALL:P57668) (165 aa) fasta scores: E(): 4.8e-32, 55.75% id in 165 aa; thiol peroxidase 1381041 tpx 2649893 tpx Corynebacterium diphtheriae NCTC 13129 thiol peroxidase NP_939715.1 1380544 R 257309 CDS NP_939716.1 38233949 2649894 1381185..1382027 1 NC_002935.2 Similar to Mycobacterium tuberculosis probable peptidyl-prolyl cis-trans isomerase B PpiB or Ppi or Rv2582 or MT2659 or MTCY227.19c SWALL:PPIB_MYCTU (SWALL:Q50639) (308 aa) fasta scores: E(): 5.5e-37, 46.23% id in 292 aa, and to Streptomyces coelicolor peptidyl-prolyl cis-trans isomerase SC9C5.34 SWALL:Q9KXP0 (EMBL:AL357523) (277 aa) fasta scores: E(): 3.5e-26, 37.5% id in 288 aa; isomerase 1382027 2649894 DIP1363 Corynebacterium diphtheriae NCTC 13129 isomerase NP_939716.1 1381185 D 257309 CDS NP_939717.1 38233950 2649895 1382185..1382466 1 NC_002935.2 hypothetical protein 1382466 2649895 DIP1364 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939717.1 1382185 D 257309 CDS NP_939718.1 38233951 2649896 1382517..1382657 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 1382657 2649896 DIP1365 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939718.1 1382517 D 257309 CDS NP_939719.1 38233952 2649897 1382700..1384079 1 NC_002935.2 Similar to, although shorter than Escherichia coli possible transposase of IS1353 YahA SWALL:Q9WTH9 (EMBL:AP000342) (514 aa) fasta scores: E(): 1.4e-62, 41.59% id in 464 aa, and similar in its C-terminal region to Escherichia coli transposase InsK for insertion sequence element IS150 InsK or B3558 SWALL:INSK_ECOLI (SWALL:P19769) (283 aa) fasta scores: E(): 1.4e-35, 38.98% id in 277 aa; transposase 1384079 2649897 DIP1366 Corynebacterium diphtheriae NCTC 13129 transposase NP_939719.1 1382700 D 257309 CDS NP_939720.1 38233953 2649899 complement(1384750..1387029) 1 NC_002935.2 Similar to Corynebacterium glutamicum GTP pyrophosphokinase RelA or Rel SWALL:RELA_CORGL (SWALL:O87331) (760 aa) fasta scores: E(): 0, 86.05% id in 760 aa, and to Escherichia coli GTP pyrophosphokinase RelA or B2784 or Z4099 or ECS3644 SWALL:RELA_ECOLI (SWALL:P11585) (744 aa) fasta scores: E(): 4.1e-97, 36.54% id in 684 aa, and to Streptomyces coelicolor GTP pyrophosphokinase RelA or SCL2.03c SWALL:RELA_STRCO (SWALL:P52560) (847 aa) fasta scores: E(): 7.3e-90, 58.33% id in 768 aa; GTP pyrophosphokinase 1387029 relA 2649899 relA Corynebacterium diphtheriae NCTC 13129 GTP pyrophosphokinase NP_939720.1 1384750 R 257309 CDS NP_939721.1 38233954 2649900 complement(1387088..1387642) 1 NC_002935.2 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 1387642 apt 2649900 apt Corynebacterium diphtheriae NCTC 13129 adenine phosphoribosyltransferase NP_939721.1 1387088 R 257309 CDS NP_939722.1 38233955 2649901 complement(1387698..1389449) 1 NC_002935.2 Similar to Corynebacterium glutamicum dipeptide-binding protein DciaE SWALL:O87329 (EMBL:AF038651) (502 aa) fasta scores: E(): 4e-83, 48.61% id in 434 aa, and to Mycobacterium tuberculosis hypothetical lipoprotein Rv2585c precursor or MT2662 or MTCY227.16 SWALL:YP85_MYCTU (SWALL:Q50636) (557 aa) fasta scores: E(): 7.1e-30, 29.09% id in 574 aa; hypothetical protein 1389449 2649901 DIP1370 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939722.1 1387698 R 257309 CDS NP_939723.1 38233956 2649902 complement(1389519..1390631) 1 NC_002935.2 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 1390631 secF 2649902 secF Corynebacterium diphtheriae NCTC 13129 preprotein translocase subunit SecF NP_939723.1 1389519 R 257309 CDS NP_939724.1 38233957 2649903 complement(1390632..1392410) 1 NC_002935.2 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 1392410 secD 2649903 secD Corynebacterium diphtheriae NCTC 13129 preprotein translocase subunit SecD NP_939724.1 1390632 R 257309 CDS NP_939725.1 38233958 2649904 complement(1392415..1392600) 1 NC_002935.2 hypothetical protein 1392600 2649904 DIP1373 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939725.1 1392415 R 257309 CDS NP_939726.1 38233959 2649905 complement(1392641..1392934) 1 NC_002935.2 Similar to Corynebacterium glutamicum hypothetical 13.5 kDa protein SWALL:Q9AE08 (EMBL:AF038651) (121 aa) fasta scores: E(): 7.2e-10, 34.83% id in 89 aa, and to Mycobacterium tuberculosis hypothetical 13.0 kDa protein Rv2588c precursor or MT2665 or MTCY227.13 SWALL:YP88_MYCTU (SWALL:Q50633) (115 aa) fasta scores: E(): 5.9e-05, 37.77% id in 90 aa; hypothetical protein 1392934 2649905 DIP1374 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939726.1 1392641 R 257309 CDS NP_939727.1 38233960 2649906 complement(1392938..1394026) 1 NC_002935.2 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1394026 ruvB 2649906 ruvB Corynebacterium diphtheriae NCTC 13129 Holliday junction DNA helicase RuvB NP_939727.1 1392938 R 257309 CDS NP_939728.1 38233961 2649907 complement(1394044..1394655) 1 NC_002935.2 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 1394655 ruvA 2649907 ruvA Corynebacterium diphtheriae NCTC 13129 Holliday junction DNA helicase RuvA NP_939728.1 1394044 R 257309 CDS NP_939729.1 38233962 2649908 complement(1394694..1395185) 1 NC_002935.2 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 1395185 ruvC 2649908 ruvC Corynebacterium diphtheriae NCTC 13129 Holliday junction resolvase NP_939729.1 1394694 R 257309 CDS NP_939730.1 38233963 2649909 complement(1395368..1396120) 1 NC_002935.2 Highly similar to Corynebacterium glutamicum hypothetical structural protein YfcA SWALL:Q9AE12 (EMBL:AF038651) (251 aa) fasta scores: E(): 2.7e-76, 83.53% id in 249 aa, and to Escherichia coli protein YebC in 249 aa; hypothetical protein 1396120 yfcA 2649909 yfcA Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939730.1 1395368 R 257309 CDS NP_939731.1 38233964 2649910 complement(1396358..1397212) 1 NC_002935.2 Similar to Mycobacterium tuberculosis TesB or TesB2 or Rv2605c or MTCY01A10.28 SWALL:O06209 (EMBL:Z95387) (281 aa) fasta scores: E(): 1.9e-49, 50.17% id in 279 aa, and to Escherichia coli acyl-CoA thioesterase II TesB or B0452 or Z0564 or ECS0506 SWALL:TESB_ECOLI (SWALL:P23911) (285 aa) fasta scores: E(): 3e-20, 37.27% id in 279 aa; acyl-CoA thioesterase 1397212 tesB 2649910 tesB Corynebacterium diphtheriae NCTC 13129 acyl-CoA thioesterase NP_939731.1 1396358 R 257309 CDS NP_939732.1 38233965 2649911 1397443..1398588 1 NC_002935.2 hypothetical protein 1398588 2649911 DIP1380 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939732.1 1397443 D 257309 CDS NP_939733.1 38233966 2649912 1398642..1399385 1 NC_002935.2 catalyzes the formation of pimeloyl-CoA from pimelate and coenzyme A; 6-carboxyhexanoate--CoA ligase 1399385 2649912 DIP1381 Corynebacterium diphtheriae NCTC 13129 6-carboxyhexanoate--CoA ligase NP_939733.1 1398642 D 257309 CDS NP_939734.1 38233967 2649913 1399385..1400575 1 NC_002935.2 Similar to Bacillus sphaericus 8-amino-7-oxononanoate synthase BioF SWALL:BIOF_BACSH (SWALL:P22806) (389 aa) fasta scores: E(): 8.9e-47, 40.95% id in 376 aa, and to Escherichia coli 8-amino-7-oxononanoate synthase BioF or B0776 SWALL:BIOF_ECOLI (SWALL:P12998) (384 aa) fasta scores: E(): 9.8e-39, 37.39% id in 353 aa; aminotransferase 1400575 2649913 DIP1382 Corynebacterium diphtheriae NCTC 13129 aminotransferase NP_939734.1 1399385 D 257309 CDS NP_939735.1 38233968 2649914 complement(1400572..1401033) 1 NC_002935.2 Similar to the N-terminal region of Mycobacterium tuberculosis CDC1551 MutT/NudIX family protein MT2684 SWALL:AAK47000 (EMBL:AE007101) (351 aa) fasta scores: E(): 1.2e-06, 42.2% id in 154 aa, and to Streptomyces coelicolor hypothetical 19.8 kDa protein SCL2.14c SWALL:Q9L285 (EMBL:AL137778) (180 aa) fasta scores: E(): 0.0099, 35.88% id in 170 aa; hypothetical protein 1401033 2649914 DIP1383 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939735.1 1400572 R 257309 CDS NP_939736.1 38233969 2649915 complement(1401045..1402136) 1 NC_002935.2 Similar to Streptomyces coelicolor sugar transferase SCL2.15c SWALL:Q9L284 (EMBL:AL137778) (387 aa) fasta scores: E(): 3.5e-45, 49.06% id in 375 aa, and to Mycobacterium tuberculosis CDC1551 glycosyl transferase MT2685 SWALL:AAK47001 (EMBL:AE007101) (378 aa) fasta scores: E(): 9.2e-42, 47.89% id in 380 aa; transferase (LPS related) 1402136 2649915 DIP1384 Corynebacterium diphtheriae NCTC 13129 transferase (LPS related) NP_939736.1 1401045 R 257309 CDS NP_939737.1 38233970 2649916 complement(1402163..1403104) 1 NC_002935.2 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 1403104 2649916 DIP1385 Corynebacterium diphtheriae NCTC 13129 lipid A biosynthesis lauroyl acyltransferase NP_939737.1 1402163 R 257309 CDS NP_939738.1 38233971 2649917 complement(1403131..1403784) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, MT2687 SWALL:AAK47003 (EMBL:AE007101) (217 aa) fasta scores: E(): 6.9e-34, 48.29% id in 205 aa, and to Mycobacterium smegmatis phosphatidylinositol synthase PgsA SWALL:Q9F7Y9 (EMBL:AF265558) (222 aa) fasta scores: E(): 8.7e-31, 47% id in 200 aa; phosphatidyltransferase 1403784 2649917 DIP1386 Corynebacterium diphtheriae NCTC 13129 phosphatidyltransferase NP_939738.1 1403131 R 257309 CDS NP_939739.1 38233972 2649918 complement(1403777..1404361) 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical protein ML0455 SWALL:Q9CCU0 (EMBL:AL583918) (206 aa) fasta scores: E(): 6.3e-43, 61.49% id in 174 aa, and to Mycobacterium leprae hypothetical 20.7 kDa protein MLCl581.17c SWALL:O07150 (EMBL:Z96801) (186 aa) fasta scores: E(): 4.1e-42, 62.13% id in 169 aa; hypothetical protein 1404361 2649918 DIP1387 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939739.1 1403777 R 257309 CDS NP_939740.1 38233973 2649919 complement(1404545..1406608) 1 NC_002935.2 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 1406608 thrS 2649919 thrS Corynebacterium diphtheriae NCTC 13129 threonyl-tRNA synthetase NP_939740.1 1404545 R 257309 CDS NP_939741.1 38233974 2648907 complement(1406797..1408017) 1 NC_002935.2 Similar to Yersinia pestis hypothetical protein YPO1856 SWALL:Q8ZF62 (EMBL:AJ414150) (434 aa) fasta scores: E(): 8.7e-30, 33.74% id in 406 aa, and to Escherichia coli hypothetical protein YcdB precursor or B1019 SWALL:YCDB_ECOLI (SWALL:P31545) (423 aa) fasta scores: E(): 2.4e-29, 32.22% id in 419 aa. Note: Contains a twin-arginine translocation (TAT) system recognition motif (RRGFLT) at the N-terminal region; hypothetical protein 1408017 2648907 DIP1389 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939741.1 1406797 R 257309 CDS NP_939742.1 38233975 2648908 complement(1408111..1408725) 1 NC_002935.2 Low similarity to Vibrio cholerae hypothetical protein VCA0037 SWALL:Q9KNC8 (EMBL:AE004347) (150 aa) fasta scores: E(): 9.6e-09, 34.09% id in 132 aa, and to Rhizobium loti MLL3326 protein SWALL:Q98GH4 (EMBL:AP003001) (179 aa) fasta scores: E(): 3.1e-05, 29.45% id in 146 aa; hypothetical protein 1408725 2648908 DIP1390 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939742.1 1408111 R 257309 CDS NP_939743.1 38233976 2649274 complement(1408732..1409376) 1 NC_002935.2 hypothetical protein 1409376 2649274 DIP1391 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939743.1 1408732 R 257309 CDS NP_939744.1 38233977 2649467 1410549..1411358 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical 29.0 kDa protein ML1340 or MLC1351.23 TR:O05684 (EMBL:Z95117) (268 aa) fasta scores: E(): 1.4e-12, 30.97% id in 226 aa, and to Mycobacterium tuberculosis hypothetical 27.7 kDa protein CY441.40 Rv2671 or MT2745 or MTCY441.40 TR:AAK47060 (EMBL:Z80225) (239 aa) fasta scores: E(): 9.8e-12, 29.27% id in 222 aa; hypothetical protein 1411358 2649467 DIP1392 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939744.1 1410549 D 257309 CDS NP_939745.1 38233978 2649468 1411416..1411826 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 PilB-related protein MT2748 TR:AAK47063 (EMBL:AE007105) (136 aa) fasta scores: E(): 6.2e-39, 70.67% id in 133 aa, and to Streptomyces coelicolor oxidoreductase SC9B1.08 TR:Q9X828 (EMBL:AL049727) (135 aa) fasta scores: E(): 4.3e-33, 67.74% id in 124 aa; hypothetical protein 1411826 2649468 DIP1393 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939745.1 1411416 D 257309 CDS NP_939746.1 38233979 2649469 complement(1411905..1412609) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT2750 TR:AAK47065 (EMBL:AE007105) (231 aa) fasta scores: E(): 3e-55, 59.3% id in 231 aa, and to Streptomyces coelicolor hypothetical 28.1 kDa protein Sc1B5.02 TR:O69830 (EMBL:AL023517) (243 aa) fasta scores: E(): 5.5e-48, 54.7% id in 223 aa; hypothetical protein 1412609 2649469 DIP1394 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939746.1 1411905 R 257309 CDS NP_939747.1 38233980 2649470 1412834..1413415 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 22.6 kDa protein Rv2680 or MT2754 or MTV010.04 TR:O86317 (EMBL:Z96072) (210 aa) fasta scores: E(): 2.7e-38, 56.59% id in 182 aa, and to Streptomyces coelicolor hypothetical 24.7 kDa protein Sc1C3.1cC TR:O69860 (EMBL:AL023702) (238 aa) fasta scores: E(): 1.2e-22, 41.17% id in 187 aa; hypothetical protein 1413415 2649470 DIP1395 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939747.1 1412834 D 257309 CDS NP_939748.1 38233981 2649471 1413434..1414657 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 ribonuclease D, MT2755 TR:AAK47070 (EMBL:AE007105) (438 aa) fasta scores: E(): 5.1e-49, 38.14% id in 409 aa, and to Escherichia coli ribonuclease D Rnd or B1804 SW:RND_ECOLI (P09155) (375 aa) fasta scores: E(): 1.2e-10, 28.36% id in 342 aa; ribonuclease 1414657 2649471 DIP1396 Corynebacterium diphtheriae NCTC 13129 ribonuclease NP_939748.1 1413434 D 257309 CDS NP_939749.1 38233982 2649472 complement(1414718..1416625) 1 NC_002935.2 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 1416625 dxs 2649472 dxs Corynebacterium diphtheriae NCTC 13129 1-deoxy-D-xylulose-5-phosphate synthase NP_939749.1 1414718 R 257309 CDS NP_939750.1 38233983 2649473 complement(1416837..1418099) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 43.2 kDa protein Rv2689c or MT2763 or MTCY05A6.10c TR:O07191 (EMBL:Z96072) (405 aa) fasta scores: E(): 3.4e-27, 40.39% id in 401 aa, and to Streptomyces coelicolor SC10A5.06 protein TR:O54099 (EMBL:AL021529) (458 aa) fasta scores: E(): 1e-20, 31.59% id in 440 aa; hypothetical protein 1418099 2649473 DIP1398 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939750.1 1416837 R 257309 CDS NP_939751.1 38233984 2649474 complement(1418417..1419136) 1 NC_002935.2 Similar to Mycobacterium leprae U1764K ML1029 TR:Q49993 (EMBL:U15181) (273 aa) fasta scores: E(): 1e-24, 38.88% id in 234 aa, and to Mycobacterium tuberculosis hypothetical 27.2 kDa protein Rv2696c or MTCY05A6.17c TR:O07198 (EMBL:Z96072) (259 aa) fasta scores: E(): 1.5e-24, 37.34% id in 241 aa; hypothetical protein 1419136 2649474 DIP1399 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939751.1 1418417 R 257309 CDS NP_939752.1 38233985 2649475 complement(1419195..1419653) 1 NC_002935.2 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 1419653 dut 2649475 dut Corynebacterium diphtheriae NCTC 13129 deoxyuridine 5'-triphosphate nucleotidohydrolase NP_939752.1 1419195 R 257309 CDS NP_939753.1 38233986 2649476 1419796..1420308 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 17.6 kDa protein Rv2698 or MTCY05A6.19 TR:O07200 (EMBL:Z96072) (161 aa) fasta scores: E(): 1.9e-21, 45.28% id in 159 aa, and to Mycobacterium leprae U1764I ML12027 TR:Q49991 (EMBL:U15181) (157 aa) fasta scores: E(): 3e-19, 41.77% id in 158 aa; hypothetical protein 1420308 2649476 DIP1401 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939753.1 1419796 D 257309 CDS NP_939754.1 38233987 2649477 complement(1420344..1420637) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT2773 TR:AAK47088 (EMBL:AE007106) (100 aa) fasta scores: E(): 1.6e-17, 57% id in 100 aa, and to Streptomyces coelicolor hypothetical 11.0 kDa protein SC2E9.05 TR:O54130 (EMBL:AL021530) (98 aa) fasta scores: E(): 4.9e-14, 49.49% id in 99 aa; hypothetical protein 1420637 2649477 DIP1402 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939754.1 1420344 R 257309 CDS NP_939755.1 38233988 2649478 complement(1420829..1421662) 1 NC_002935.2 Similar to Mycobacterium tuberculosis inositol-1-monophosphatase SuhB or Rv2701c or MT2775 or MTCY05A6.22c SW:SUHB_MYCTU (O07203) (290 aa) fasta scores: E(): 1e-38, 45% id in 280 aa, and to Escherichia coli inositol-1-monophosphatase SuhB or SsyA or B2533 SW:SUHB_ECOLI (P22783) (267 aa) fasta scores: E(): 3.2e-19, 37.22% id in 231 aa; hydrolase 1421662 2649478 DIP1403 Corynebacterium diphtheriae NCTC 13129 hydrolase NP_939755.1 1420829 R 257309 CDS NP_939756.1 38233989 2649479 1421865..1422626 1 NC_002935.2 Similar to Mycobacterium tuberculosis polyphosphate glucokinase PpgK or Rv2702 or MT2776 or MTCY05A6.23 SW:PPGK_MYCTU (Q59568) (265 aa) fasta scores: E(): 1.5e-50, 57.91% id in 240 aa, and to Corynebacterium ammoniagenes polyphosphate glucokinase PpgK TR:Q9AGV8 (EMBL:AF326348) (277 aa) fasta scores: E(): 3.2e-59, 63.85% id in 249 aa; polyphosphate glucokinase 1422626 ppgK 2649479 ppgK Corynebacterium diphtheriae NCTC 13129 polyphosphate glucokinase NP_939756.1 1421865 D 257309 CDS NP_939757.1 38233990 2649480 1422759..1422956 1 NC_002935.2 hypothetical protein 1422956 2649480 DIP1405 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939757.1 1422759 D 257309 CDS NP_939758.1 38233991 2649481 1423091..1424599 1 NC_002935.2 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; RNA polymerase sigma factor 1424599 sigA 2649481 sigA Corynebacterium diphtheriae NCTC 13129 RNA polymerase sigma factor NP_939758.1 1423091 D 257309 CDS NP_939759.1 38233992 2649482 complement(1424933..1425406) 1 NC_002935.2 hypothetical protein 1425406 2649482 DIP1407 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939759.1 1424933 R 257309 CDS NP_939760.1 38233993 2649483 complement(1425515..1427224) 1 NC_002935.2 Similar, but shorter in its N-terminal region, to Mycobacterium tuberculosis hypothetical 65.8 kDa protein Rv2917 or MT2985 or MTCY338.05 SW:YT17_MYCTU (Q10966) (602 aa) fasta scores: E(): 6.4e-116, 62.39% id in 569 aa, and to Mycobacterium leprae hypothetical 65.2 kDa protein ML1624 or MLCB250.18c SW:YT17_MYCLE (O33011) (596 aa) fasta scores: E(): 8.8e-113, 60.28% id in 569 aa; hypothetical protein 1427224 2649483 DIP1408 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939760.1 1425515 R 257309 CDS NP_939761.1 38233994 2649484 complement(1427224..1427463) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT2781 TR:AAK47097 (EMBL:AE007107) (82 aa) fasta scores: E(): 1.4e-17, 65.78% id in 76 aa, and to Mycobacterium leprae U1764c ML1016 TR:Q49984 (EMBL:U15181) (107 aa) fasta scores: E(): 2.8e-16, 65.78% id in 76 aa; hypothetical protein 1427463 2649484 DIP1409 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939761.1 1427224 R 257309 CDS NP_939762.1 38233995 2649485 1427523..1428011 1 NC_002935.2 hypothetical protein 1428011 2649485 DIP1410 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939762.1 1427523 D 257309 CDS NP_939763.1 38233996 2649486 1428054..1429589 1 NC_002935.2 Similar to Streptomyces coelicolor transferase SCH5.08c TR:Q9X911 (EMBL:AL035636) (505 aa) fasta scores: E(): 3.6e-46, 35.44% id in 522 aa; transferase 1429589 2649486 DIP1411 Corynebacterium diphtheriae NCTC 13129 transferase NP_939763.1 1428054 D 257309 CDS NP_939764.1 38233997 2649487 1429600..1430037 1 NC_002935.2 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 1430037 2649487 DIP1412 Corynebacterium diphtheriae NCTC 13129 D-tyrosyl-tRNA(Tyr) deacylase NP_939764.1 1429600 D 257309 CDS NP_939765.1 38233998 2649488 1430121..1431110 1 NC_002935.2 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase; RNA polymerase sigma factor SigB 1431110 sigB 2649488 sigB Corynebacterium diphtheriae NCTC 13129 RNA polymerase sigma factor SigB NP_939765.1 1430121 D 257309 CDS NP_939766.1 38233999 2649688 1431335..1432015 1 NC_002935.2 Almost identical to the previously sequenced Corynebacterium diphtheriae diphtheria toxin repressor DtxR SW:DTXR_CORDI (P33120) (226 aa) fasta scores: E(): 7.6e-81, 99.11% id in 226 aa, and similar to Corynebacterium equii iron dependent regulatory protein IdeR TR:Q9F7T3 (EMBL:AF277002) (230 aa) fasta scores: E(): 1.1e-43, 56.71% id in 231 aa; diphtheria toxin repressor 1432015 dtxR 2649688 dtxR Corynebacterium diphtheriae NCTC 13129 diphtheria toxin repressor NP_939766.1 1431335 D 257309 CDS NP_939767.1 38234000 2649689 1432038..1433024 1 NC_002935.2 Almost identical to previously sequenced Corynebacterium diphtheriae UDP-glucose 4-epimerase GalE SW:GALE_CORDI (P33119) (328 aa) fasta scores: E(): 1.6e-126, 99.39% id in 328 aa, and to Corynebacterium glutamicum UDP-glucose 4-epimerase GalE SW:GALE_CORGL (Q45291) (329 aa) fasta scores: E(): 5.1e-97, 75.22% id in 327 aa, and to Lactobacillus casei UDP-glucose 4-epimerase GalE SW:GALE_LACCA (O84903) (331 aa) fasta scores: E(): 3.1e-55, 48.89% id in 317 aa; UDP-glucose 4-epimerase 1433024 galE 2649689 galE Corynebacterium diphtheriae NCTC 13129 UDP-glucose 4-epimerase NP_939767.1 1432038 D 257309 CDS NP_939768.1 38234001 2649690 complement(1433073..1434116) 1 NC_002935.2 hypothetical protein 1434116 2649690 DIP1416 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939768.1 1433073 R 257309 CDS NP_939769.1 38234002 2649691 1434368..1435309 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT2787 TR:AAK47103 (EMBL:AE007107) (324 aa) fasta scores: E(): 2.1e-45, 45.09% id in 306 aa, and to Streptomyces coelicolor conserved hypothetical protein SCI52.04 TR:Q9ADA5 (EMBL:AL590507) (333 aa) fasta scores: E(): 4.2e-12, 26.64% id in 304 aa; hypothetical protein 1435309 2649691 DIP1417 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939769.1 1434368 D 257309 CDS NP_939770.1 38234003 2649692 1435342..1437876 1 NC_002935.2 Similar in its full length to Streptomyces coelicolor helicase SCG8A.06 TR:Q9KZJ3 (EMBL:AL353863) (854 aa) fasta scores: E(): 2.1e-184, 56.4% id in 828 aa, and to the C-terminal region of Schizosaccharomyces pombe helicase SPAC6F12.16c SW:YDVG_SCHPO (O14232) (1117 aa) fasta scores: E(): 1.5e-13, 27.64% id in 445 aa; helicase 1437876 2649692 DIP1418 Corynebacterium diphtheriae NCTC 13129 helicase NP_939770.1 1435342 D 257309 CDS NP_939771.1 38234004 2649693 complement(1437952..1438476) 1 NC_002935.2 Similar to Mycobacterium tuberculosis AhpD protein or Rv2429 or MT2504 or MTCY428.17c SW:AHPD_MYCTU (Q57353) (177 aa) fasta scores: E(): 1.5e-38, 59.53% id in 173 aa, and to Streptomyces viridosporus hypothetical 18.8 kDa protein AhpX TR:Q9X5V1 (EMBL:AF127576) (174 aa) fasta scores: E(): 1.5e-28, 49.13% id in 173 aa; hypothetical protein 1438476 2649693 DIP1419 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939771.1 1437952 R 257309 CDS NP_939772.1 38234005 2649694 complement(1438479..1439075) 1 NC_002935.2 Almost identical to previously sequenced Corynebacterium diphtheriae iron repressible polypeptide DirA TR:Q46025 (EMBL:U18620) (198 aa) fasta scores: E(): 8.8e-79, 98.99% id in 198 aa, and to Mycobacterium smegmatis alkyl hydroperoxide reductase C AhpC TR:Q57529 (EMBL:U43719) (195 aa) fasta scores: E(): 5.2e-52, 66.12% id in 186 aa; iron repressible polypeptide 1439075 dirA 2649694 dirA Corynebacterium diphtheriae NCTC 13129 iron repressible polypeptide NP_939772.1 1438479 R 257309 CDS NP_939773.1 38234006 2649695 1439301..1440239 1 NC_002935.2 Similar to Erwinia carotovora hydrogen peroxide-inducible genes activator OxyR SW:OXYR_ERWCA (P71318) (302 aa) fasta scores: E(): 1.6e-34, 37.5% id in 296 aa, and to Escherichia coli hydrogen peroxide-inducible genes activator OxyR or MomR or Mor or B3961 or Z5519 or ECS4890 SW:OXYR_ECOLI (P11721) (305 aa) fasta scores: E(): 7e-34, 37.8% id in 291 aa; transcriptional regulator 1440239 2649695 DIP1421 Corynebacterium diphtheriae NCTC 13129 transcriptional regulator NP_939773.1 1439301 D 257309 CDS NP_939774.1 38234007 2649696 complement(1440295..1441260) 1 NC_002935.2 hypothetical protein 1441260 2649696 DIP1422 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939774.1 1440295 R 257309 CDS NP_939775.1 38234008 2649697 1441388..1445341 1 NC_002935.2 Similar to Escherichia coli ATP-dependent helicase HrpA or B1413 SW:HRPA_ECOLI (P43329) (1300 aa) fasta scores: E(): 1.7e-172, 46.92% id in 1315 aa, and to Vibrio cholerae ATP-dependent helicase HrpA VC1382 TR:Q9KS77 (EMBL:AE004217) (1309 aa) fasta scores: E(): 2.3e-171, 47.6% id in 1317 aa; ATP-dependent helicase 1445341 2649697 DIP1423 Corynebacterium diphtheriae NCTC 13129 ATP-dependent helicase NP_939775.1 1441388 D 257309 CDS NP_939776.1 38234009 2649698 complement(1445404..1445859) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 17.2 kDa protein Rv2718c or MT2791 or MTCY05A6.39c SW:YR18_MYCTU (O07217) (154 aa) fasta scores: E(): 1.3e-35, 69.65% id in 145 aa, and to Bacillus subtilis hypothetical protein YtcG SW:YTCG_BACSU (Q45549) (152 aa) fasta scores: E(): 1.4e-21, 42% id in 150 aa; transcriptional regulator NrdR 1445859 nrdR 2649698 nrdR Corynebacterium diphtheriae NCTC 13129 transcriptional regulator NrdR NP_939776.1 1445404 R 257309 CDS NP_939777.1 38234010 2649699 complement(1445957..1446292) 1 NC_002935.2 hypothetical protein 1446292 2649699 DIP1425 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939777.1 1445957 R 257309 CDS NP_939778.1 38234011 2649700 1446632..1447345 1 NC_002935.2 Represses a number of genes involved in the response to DNA damage; LexA repressor 1447345 lexA 2649700 lexA Corynebacterium diphtheriae NCTC 13129 LexA repressor NP_939778.1 1446632 D 257309 CDS NP_939779.1 38234012 2649701 1447668..1448444 1 NC_002935.2 Similar to Streptomyces coelicolor DeoR-family transcriptional regulator SCE22.15c TR:Q9KYU7 (EMBL:AL355832) (253 aa) fasta scores: E(): 9.3e-31, 44.85% id in 243 aa, and to Escherichia coli galactitol utilization operon repressor GatR or B2087/B2090 SW:GATR_ECOLI (P36930) (259 aa) fasta scores: E(): 3.9e-20, 35.76% id in 260 aa. Note: Similar also to the downstream CDIP1429 267 aa, 41.634% identity in 257 aa overlap; sugar related operon transcriptional regulator 1448444 2649701 DIP1427 Corynebacterium diphtheriae NCTC 13129 sugar related operon transcriptional regulator NP_939779.1 1447668 D 257309 CDS NP_939780.1 38234013 2649702 complement(1448538..1450232) 1 NC_002935.2 Similar to Corynebacterium glutamicum phosphoenolpyruvate:sugar phosphotransferase system enzyme I PtsI TR:AAK76445 (EMBL:AF392620) (565 aa) fasta scores: E(): 2.9e-159, 76.69% id in 562 aa, and to Xanthomonas campestris multiphosphoryl transfer protein FruB SW:PTF1_XANCP (P45597) (837 aa) fasta scores: E(): 1.4e-50, 37.2% id in 559 aa; phosphoenolpyruvate:sugar phosphotransferase system enzyme I 1450232 ptsI 2649702 ptsI Corynebacterium diphtheriae NCTC 13129 phosphoenolpyruvate:sugar phosphotransferase system enzyme I NP_939780.1 1448538 R 257309 CDS NP_939781.1 38234014 2649703 1450500..1451303 1 NC_002935.2 Similar to Spiroplasma citri transcriptional regulator FruR TR:Q9RMF6 (EMBL:AF202665) (233 aa) fasta scores: E(): 7.3e-17, 33.75% id in 237 aa, and to Escherichia coli galactitol utilization operon repressor GatR or B2087/B2090 SW:GATR_ECOLI (P36930) (259 aa) fasta scores: E(): 4e-13, 30% id in 240 aa. Note: Similar also to the upstream CDIP1427 258 aa, 41.634% identity in 257 aa overlap; sugar related operon transcriptional regulator 1451303 2649703 DIP1429 Corynebacterium diphtheriae NCTC 13129 sugar related operon transcriptional regulator NP_939781.1 1450500 D 257309 CDS NP_939782.1 38234015 2649704 1451300..1452265 1 NC_002935.2 Similar to Rhodobacter capsulatus 1-phosphofructokinase FruK SW:K1PF_RHOCA (P23386) (316 aa) fasta scores: E(): 1.2e-05, 32.6% id in 322 aa, and to Escherichia coli 6-phosphofructokinase isozyme 2 PfkB or B1723 SW:K6P2_ECOLI (P06999) (309 aa) fasta scores: E(): 0.00069, 30.51% id in 308 aa; phosphofructokinase 1452265 2649704 DIP1430 Corynebacterium diphtheriae NCTC 13129 phosphofructokinase NP_939782.1 1451300 D 257309 CDS NP_939783.1 38234016 2649706 1454634..1454900 1 NC_002935.2 Similar to Bacillus megaterium phosphocarrier protein HPr PtsH SW:PTHP_BACME (O69250) (88 aa) fasta scores: E(): 3e-06, 37.5% id in 80 aa, and to Bacillus subtilis phosphocarrier protein HPr PtsH SW:PTHP_BACSU (P08877) (87 aa) fasta scores: E(): 0.00032, 30.86% id in 81 aa; PTS system carbohydrate carrier protein 1454900 2649706 DIP1435 Corynebacterium diphtheriae NCTC 13129 PTS system carbohydrate carrier protein NP_939783.1 1454634 D 257309 CDS NP_939784.1 38234017 2649707 1455065..1456183 1 NC_002935.2 Similar to Streptomyces coelicolor oxidoreductase SCE15.13c TR:Q9X888 (EMBL:AL049707) (367 aa) fasta scores: E(): 1.8e-106, 72.11% id in 355 aa, and to Photorhabdus luminescens alkanal monooxygenase alpha chain LuxA SW:LXA1_PHOLU (P19839) (360 aa) fasta scores: E(): 2.5e-06, 25.87% id in 228 aa; oxidoreductase 1456183 2649707 DIP1436 Corynebacterium diphtheriae NCTC 13129 oxidoreductase NP_939784.1 1455065 D 257309 CDS NP_939785.1 38234018 2649708 1456242..1456907 1 NC_002935.2 Similar to Streptomyces coelicolor oxidoreductase SCE15.12c TR:Q9X887 (EMBL:AL049707) (222 aa) fasta scores: E(): 1.1e-26, 46.15% id in 221 aa, and to the middle region of Escherichia coli NAD SsuE or B0937 SW:SSUE_ECOLI (P80644) (191 aa) fasta scores: E(): 8.8e-09, 40.35% id in 114 aa; oxidoreductase 1456907 2649708 DIP1437 Corynebacterium diphtheriae NCTC 13129 oxidoreductase NP_939785.1 1456242 D 257309 CDS NP_939786.1 38234019 2649709 complement(1456969..1458255) 1 NC_002935.2 Similar to Escherichia coli O157:H7 uracil transport protein PyrP TR:Q9KX94 (EMBL:AP000422) (442 aa) fasta scores: E(): 5e-46, 45.97% id in 422 aa, and to Escherichia coli uracil permease UraA or B2497 or Z3760 or ECS3359 SW:URAA_ECOLI (P33780) (429 aa) fasta scores: E(): 6.2e-25, 40.9% id in 396 aa; transport membrane protein 1458255 2649709 DIP1438 Corynebacterium diphtheriae NCTC 13129 transport membrane protein NP_939786.1 1456969 R 257309 CDS NP_939787.1 38234020 2649710 complement(1458338..1459948) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 53.3 kDa protein HflX or Rv2725c or MTCY154.05c TR:O33230 (EMBL:Z98209) (495 aa) fasta scores: E(): 4.6e-102, 63.75% id in 469 aa, and to Escherichia coli GTP-binding protein HflX or B4173 SW:HFLX_ECOLI (P25519) (426 aa) fasta scores: E(): 3.1e-45, 40.62% id in 416 aa; GTP-binding protein 1459948 2649710 DIP1439 Corynebacterium diphtheriae NCTC 13129 GTP-binding protein NP_939787.1 1458338 R 257309 CDS NP_939788.1 38234021 2649711 1460095..1460850 1 NC_002935.2 hypothetical protein 1460850 2649711 DIP1440 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939788.1 1460095 D 257309 CDS NP_939789.1 38234022 2649712 1460925..1461449 1 NC_002935.2 hypothetical protein 1461449 2649712 DIP1441 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939789.1 1460925 D 257309 CDS NP_939790.1 38234023 2649713 complement(1461458..1462351) 1 NC_002935.2 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 1462351 dapF 2649713 dapF Corynebacterium diphtheriae NCTC 13129 diaminopimelate epimerase NP_939790.1 1461458 R 257309 CDS NP_939791.1 38234024 2649714 complement(1462348..1463256) 1 NC_002935.2 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 1463256 miaA 2649714 miaA Corynebacterium diphtheriae NCTC 13129 tRNA delta(2)-isopentenylpyrophosphate transferase NP_939791.1 1462348 R 257309 CDS NP_939792.1 38234025 2649715 complement(1463319..1464014) 1 NC_002935.2 hypothetical protein 1464014 2649715 DIP1444 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939792.1 1463319 R 257309 CDS NP_939793.1 38234026 2649716 1464212..1465540 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 hypothetical 49.8 kDa protein MT2802 TR:AAK47120 (EMBL:AE007108) (450 aa) fasta scores: E(): 5.4e-66, 48.52% id in 441 aa; hypothetical protein 1465540 2649716 DIP1445 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939793.1 1464212 D 257309 CDS NP_939794.1 38234027 2649717 1465728..1466753 1 NC_002935.2 hypothetical protein 1466753 2649717 DIP1446 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939794.1 1465728 D 257309 CDS NP_939795.1 38234028 2649718 complement(1466762..1467400) 1 NC_002935.2 Low similarity to Mycobacterium tuberculosis CDC1551 hypothetical 19.3 kDa protein MT2802.1 TR:AAK47121 (EMBL:AE007108) (180 aa) fasta scores: E(): 3.3e-07, 25.68% id in 183 aa; hypothetical protein 1467400 2649718 DIP1447 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939795.1 1466762 R 257309 CDS NP_939796.1 38234029 2649719 complement(1467450..1469000) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 55.1 kDa protein Rv2733c or MT2803 or MTCY154.13c SW:YR33_MYCTU (O33238) (512 aa) fasta scores: E(): 2.7e-130, 67.67% id in 498 aa, and to Bacillus subtilis hypothetical 58.2 kDa protein in klb-cotE intergenic region YmcB SW:YMCB_BACSU (O31778) (509 aa) fasta scores: E(): 4.9e-65, 39.61% id in 462 aa; hypothetical protein 1469000 2649719 DIP1448 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939796.1 1467450 R 257309 CDS NP_939797.1 38234030 2649720 complement(1469157..1469738) 1 NC_002935.2 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1469738 recX 2649720 recX Corynebacterium diphtheriae NCTC 13129 recombination regulator RecX NP_939797.1 1469157 R 257309 CDS NP_939798.1 38234031 2649721 complement(1469776..1470894) 1 NC_002935.2 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1470894 recA 2649721 recA Corynebacterium diphtheriae NCTC 13129 recombinase A NP_939798.1 1469776 R 257309 CDS NP_939799.1 38234032 2650336 complement(1471150..1471341) 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical protein ML0986 TR:Q9CCC1 (EMBL:AL583920) (67 aa) fasta scores: E(): 7e-06, 39.68% id in 63 aa, and to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT2808 TR:AAK47129 (EMBL:AE007109) (68 aa) fasta scores: E(): 4.1e-05, 34.92% id in 63 aa; hypothetical protein 1471341 2650336 DIP1451 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939799.1 1471150 R 257309 CDS NP_939800.1 38234033 2650337 1471428..1472012 1 NC_002935.2 Similar to Streptococcus pyogenes biotin synthase SPY0207 TR:Q9A1L4 (EMBL:AE006489) (179 aa) fasta scores: E(): 2e-15, 37.57% id in 173 aa, and to Rhizobium meliloti hypothetical transmembrane protein SMC00964 TR:CAC45460 (EMBL:AL591785) (187 aa) fasta scores: E(): 2.7e-14, 37.43% id in 179 aa; hypothetical protein 1472012 2650337 DIP1452 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939800.1 1471428 D 257309 CDS NP_939801.1 38234034 2650338 1472076..1472768 1 NC_002935.2 Similar to Deinococcus radiodurans ABC transporter, ATP-binding protein DR2469 TR:Q9RRL9 (EMBL:AE002076) (226 aa) fasta scores: E(): 2.1e-33, 46.84% id in 222 aa, and to Rhizobium meliloti ATP-binding ABC transporter protein SMC00962 TR:CAC45462 (EMBL:AL591785) (226 aa) fasta scores: E(): 5e-27, 40.36% id in 218 aa; ABC transporter ATP-binding protein 1472768 2650338 DIP1453 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_939801.1 1472076 D 257309 CDS NP_939802.1 38234035 2650339 1472765..1473379 1 NC_002935.2 Similar to Deinococcus radiodurans conserved hypothetical protein DR2468 TR:Q9RRM0 (EMBL:AE002076) (198 aa) fasta scores: E(): 7.8e-15, 36.18% id in 199 aa, and to Rhizobium meliloti hypothetical transmembrane protein SMC00963 TR:CAC45461 (EMBL:AL591785) (201 aa) fasta scores: E(): 2.5e-07, 29.38% id in 194 aa; hypothetical protein 1473379 2650339 DIP1454 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939802.1 1472765 D 257309 CDS NP_939803.1 38234036 2650340 complement(1473435..1474274) 1 NC_002935.2 Similar in its full length to Mycobacterium tuberculosis 35 kDa protein Rv2744c or MT2815 or MTV002.09c SW:35KD_MYCTU (P31511) (270 aa) fasta scores: E(): 1.2e-51, 75.8% id in 248 aa, N-terminal region to Mycobacterium leprae B2235_C2_187 MLCB33.06c TR:Q49840 (EMBL:U00019) (167 aa) fasta scores: E(): 2.9e-27, 72.1% id in 147 aa, and C-terminal region to Mycobacterium leprae B2235_C3_214 MLCB33.05c TR:Q49845 (EMBL:U00019) (114 aa) fasta scores: E(): 3.4e-12, 58.18% id in 110 aa; hypothetical protein 1474274 2650340 DIP1455 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939803.1 1473435 R 257309 CDS NP_939804.1 38234037 2650341 complement(1474405..1474734) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 DNA-binding protein, MT2816 TR:AAK47136 (EMBL:AE007109) (112 aa) fasta scores: E(): 1.2e-09, 56.16% id in 73 aa, and to Streptomyces coelicolor hypothetical 13.6 kDa protein SC7C7.10 TR:O86815 (EMBL:AL031031) (126 aa) fasta scores: E(): 1.1e-08, 49.39% id in 83 aa; DNA-binding protein 1474734 2650341 DIP1456 Corynebacterium diphtheriae NCTC 13129 DNA-binding protein NP_939804.1 1474405 R 257309 CDS NP_939805.1 38234038 2650342 complement(1474823..1475320) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 18.5 kDa protein Sc7C7.09 TR:O86814 (EMBL:AL031031) (181 aa) fasta scores: E(): 1.7e-13, 36.87% id in 160 aa, and to the C-terminal region of Streptococcus pneumoniae competence-damage protein CinA or Exp10 or SP1941 SW:CINA_STRPN (P54184) (418 aa) fasta scores: E(): 4.3e-15, 47.86% id in 117 aa; competence-damage-like protein 1475320 2650342 DIP1457 Corynebacterium diphtheriae NCTC 13129 competence-damage-like protein NP_939805.1 1474823 R 257309 CDS NP_939806.1 38234039 2650343 complement(1475349..1475939) 1 NC_002935.2 Similar to Bacillus subtilis CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA SW:PGSA_BACSU (P46322) (193 aa) fasta scores: E(): 1.6e-12, 40.55% id in 180 aa, and to Escherichia coli CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA or B1912 or Z3000 or ECS2650 SW:PGSA_ECOLI (P06978) (181 aa) fasta scores: E(): 1.7e-10, 35.91% id in 181 aa; phosphatidyltransferase 1475939 2650343 DIP1458 Corynebacterium diphtheriae NCTC 13129 phosphatidyltransferase NP_939806.1 1475349 R 257309 CDS NP_939807.1 38234040 2650344 1476035..1476328 1 NC_002935.2 Similar to Agrobacterium tumefaciens StrC58 AGR_C_4802p TR:AAK88371 (EMBL:AE008178) (97 aa) fasta scores: E(): 2.2e-05, 33.67% id in 98 aa, and to Rhizobium loti MSR4226 protein TR:Q98EI5 (EMBL:AP003003) (98 aa) fasta scores: E(): 6e-05, 32.63% id in 95 aa; hypothetical protein 1476328 2650344 DIP1459 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939807.1 1476035 D 257309 CDS NP_939808.1 38234041 2650345 complement(1476411..1477418) 1 NC_002935.2 Similar to Streptomyces coelicolor integral membrane protein SCM1.25c TR:Q9RD18 (EMBL:AL133422) (316 aa) fasta scores: E(): 3.1e-54, 48.93% id in 327 aa, and to Xylella fastidiosa export protein XF0406 TR:Q9PG96 (EMBL:AE003892) (319 aa) fasta scores: E(): 1.3e-39, 39.43% id in 317 aa; hypothetical protein 1477418 2650345 DIP1460 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939808.1 1476411 R 257309 CDS NP_939809.1 38234042 2650346 complement(1477699..1480752) 1 NC_002935.2 Similar to Streptomyces coelicolor FtsK homolog SC7C7.05 TR:O86810 (EMBL:AL031031) (929 aa) fasta scores: E(): 2.1e-106, 50.17% id in 837 aa, and similar to C-terminal region of Escherichia coli cell division protein FtsK or B0890 SW:FTSK_ECOLI (P46889) (1329 aa) fasta scores: E(): 6.5e-34, 39.14% id in 700 aa; cell division protein 1480752 2650346 DIP1461 Corynebacterium diphtheriae NCTC 13129 cell division protein NP_939809.1 1477699 R 257309 CDS NP_939810.1 38234043 2650347 complement(1480828..1481493) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 23.6 kDa protein SC4G6.14 TR:Q9S2U0 (EMBL:AL096884) (211 aa) fasta scores: E(): 1.4e-09, 31.86% id in 204 aa, and to Mycobacterium tuberculosis hypothetical 24.0 kDa protein Rv1929c or MTCY09F9.35 TR:P95285 (EMBL:Z84498) (214 aa) fasta scores: E(): 4.3e-07, 32.71% id in 217 aa; hypothetical protein 1481493 2650347 DIP1462 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939810.1 1480828 R 257309 CDS NP_939811.1 38234044 2650348 complement(1481579..1483633) 1 NC_002935.2 Similar to Corynebacterium glutamicum hypothetical 77.6 kDa protein SW:YOR4_CORGL (P54122) (718 aa) fasta scores: E(): 1.9e-189, 79.21% id in 717 aa, and to Campylobacter jejuni hypothetical protein CJ1710c TR:Q9PLW8 (EMBL:AL139079) (664 aa) fasta scores: E(): 6.9e-65, 34.08% id in 625 aa; hypothetical protein 1483633 2650348 DIP1463 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939811.1 1481579 R 257309 CDS NP_939812.1 38234045 2650349 complement(1483636..1484541) 1 NC_002935.2 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 1484541 dapA 2650349 dapA Corynebacterium diphtheriae NCTC 13129 dihydrodipicolinate synthase NP_939812.1 1483636 R 257309 CDS NP_939813.1 38234046 2650350 complement(1484623..1485381) 1 NC_002935.2 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor; FAD-dependent thymidylate synthase 1485381 thyX 2650350 thyX Corynebacterium diphtheriae NCTC 13129 FAD-dependent thymidylate synthase NP_939813.1 1484623 R 257309 CDS NP_939814.1 38234047 2650351 complement(1485381..1486127) 1 NC_002935.2 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 1486127 dapB 2650351 dapB Corynebacterium diphtheriae NCTC 13129 dihydrodipicolinate reductase NP_939814.1 1485381 R 257309 CDS NP_939815.1 38234048 2650352 complement(1486307..1488574) 1 NC_002935.2 Similar to Mycobacterium tuberculosis guanosine pentaphosphate synthetase/ polyribonucleotide nucleotidyltransferase GpsI or Rv2783c or MTV002.48C TR:O33325 (EMBL:AL008967) (752 aa) fasta scores: E(): 1.6e-187, 71.52% id in 755 aa, and to Bacillus subtilis polyribonucleotide nucleotidyltransferase PnpA or ComR SW:PNP_BACSU (P50849) (704 aa) fasta scores: E(): 4.6e-74, 45.5% id in 723 aa, and to Corynebacterium glutamicum polyribonucleotide nucleotidyltransferase CGL1975 SWALL:Q8NP50 (EMBL:AP005280) (753 aa) fasta scores: E(): 0, 82.04% id in 752 aa; polynucleotide phosphorylase 1488574 gpsI 2650352 gpsI Corynebacterium diphtheriae NCTC 13129 polynucleotide phosphorylase NP_939815.1 1486307 R 257309 CDS NP_939816.1 38234049 2650353 complement(1488766..1489035) 1 NC_002935.2 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1489035 rpsO 2650353 rpsO Corynebacterium diphtheriae NCTC 13129 30S ribosomal protein S15 NP_939816.1 1488766 R 257309 CDS NP_939817.1 38234050 2650354 complement(1489207..1490166) 1 NC_002935.2 Similar to Rhizobium meliloti nucleoside hydrolase SMC01105 TR:CAC41852 (EMBL:AL591783) (314 aa) fasta scores: E(): 2.3e-28, 33.96% id in 315 aa, and to Crithidia fasciculata inosine-uridine preferring nucleoside hydrolase IunH SW:IUNH_CRIFA (Q27546) (314 aa) fasta scores: E(): 4.6e-26, 33.33% id in 315 aa; nucleoside hydrolase 1490166 2650354 DIP1469 Corynebacterium diphtheriae NCTC 13129 nucleoside hydrolase NP_939817.1 1489207 R 257309 CDS NP_939818.1 38234051 2650355 complement(1490204..1491175) 1 NC_002935.2 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 1491175 ribF 2650355 ribF Corynebacterium diphtheriae NCTC 13129 bifunctional riboflavin kinase/FMN adenylyltransferase NP_939818.1 1490204 R 257309 CDS NP_939819.1 38234052 2650356 1491198..1492100 1 NC_002935.2 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 1492100 truB 2650356 truB Corynebacterium diphtheriae NCTC 13129 tRNA pseudouridine synthase B NP_939819.1 1491198 D 257309 CDS NP_939820.1 38234053 2650357 complement(1492097..1492789) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 24.5 kDa protein Sc5A7.23 TR:O88029 (EMBL:AL031107) (226 aa) fasta scores: E(): 6.2e-26, 45.77% id in 201 aa, and to Streptomyces verticillus phosphopantetheinyl transferase PptA TR:Q9F0Q6 (EMBL:AF210311) (246 aa) fasta scores: E(): 1.6e-24, 44.04% id in 193 aa; transferase 1492789 2650357 DIP1472 Corynebacterium diphtheriae NCTC 13129 transferase NP_939820.1 1492097 R 257309 CDS NP_939821.1 38234054 2650358 complement(1492786..1493592) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 37.6 kDa protein Rv2795c or MTV002.60c TR:O33337 (EMBL:AL008967) (324 aa) fasta scores: E(): 1e-22, 46.79% id in 265 aa, and to Streptomyces coelicolor hypothetical 33.5 kDa protein SC5A7.22 TR:O88028 (EMBL:AL031107) (295 aa) fasta scores: E(): 1.1e-17, 41.63% id in 257 aa; hypothetical protein 1493592 2650358 DIP1473 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939821.1 1492786 R 257309 CDS NP_939822.1 38234055 2650359 complement(1493639..1494958) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 44.8 kDa protein DinF or Rv2836c or MTCY16B7.06 TR:P71616 (EMBL:Z81331) (439 aa) fasta scores: E(): 1e-72, 50.59% id in 423 aa, and to Rhizobium loti DNA-damage-inducible protein MLR5680 TR:Q98B90 (EMBL:AP003007) (471 aa) fasta scores: E(): 1.9e-19, 30.07% id in 429 aa; DNA-damage inducible protein 1494958 2650359 DIP1474 Corynebacterium diphtheriae NCTC 13129 DNA-damage inducible protein NP_939822.1 1493639 R 257309 CDS NP_939823.1 38234056 2650360 complement(1494955..1495848) 1 NC_002935.2 Similar to, although shorter in its N-terminal region than, Mycobacterium tuberculosis hypothetical 35.4 kDa protein Rv2837c or MTCY16B7.05 TR:P71615 (EMBL:Z81331) (336 aa) fasta scores: E(): 8.5e-29, 34.84% id in 287 aa, and to Clostridium acetobutylicum exopolyphosphatase CAC1804 TR:AAK79769 (EMBL:AE007689) (321 aa) fasta scores: E(): 1.9e-19, 33.19% id in 235 aa; hypothetical protein 1495848 2650360 DIP1475 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939823.1 1494955 R 257309 CDS NP_939824.1 38234057 2650361 complement(1495936..1496379) 1 NC_002935.2 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 1496379 rbfA 2650361 rbfA Corynebacterium diphtheriae NCTC 13129 ribosome-binding factor A NP_939824.1 1495936 R 257309 CDS NP_939825.1 38234058 2650362 complement(1496519..1499380) 1 NC_002935.2 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 1499380 infB 2650362 infB Corynebacterium diphtheriae NCTC 13129 translation initiation factor IF-2 NP_939825.1 1496519 R 257309 CDS NP_939826.1 38234059 2650363 complement(1499491..1499823) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT2906 TR:AAK47232 (EMBL:AE007115) (99 aa) fasta scores: E(): 1.3e-06, 43.67% id in 87 aa, and to Rhizobium meliloti hypothetical protein SMC02913 TR:CAC41675 (EMBL:AL591783) (230 aa) fasta scores: E(): 0.00061, 32.14% id in 112 aa; hypothetical protein 1499823 2650363 DIP1478 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939826.1 1499491 R 257309 CDS NP_939827.1 38234060 2650364 complement(1500079..1501077) 1 NC_002935.2 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 1501077 nusA 2650364 nusA Corynebacterium diphtheriae NCTC 13129 transcription elongation factor NusA NP_939827.1 1500079 R 257309 CDS NP_939828.1 38234061 2650365 complement(1501074..1501628) 1 NC_002935.2 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 1501628 2650365 DIP1480 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939828.1 1501074 R 257309 CDS NP_939829.1 38234062 2650366 1501680..1502588 1 NC_002935.2 hypothetical protein 1502588 2650366 DIP1481 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939829.1 1501680 D 257309 CDS NP_939830.1 38234063 2650367 complement(1502667..1504424) 1 NC_002935.2 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 1504424 proS 2650367 proS Corynebacterium diphtheriae NCTC 13129 prolyl-tRNA synthetase NP_939830.1 1502667 R 257309 CDS NP_939831.1 38234064 2650368 1504456..1505202 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 27.2 kDa protein SCC30.05 TR:Q9L016 (EMBL:AL352972) (260 aa) fasta scores: E(): 4.2e-19, 34.61% id in 260 aa, and to Neisseria meningitidis hypothetical protein NMA1114 TR:Q9JUV9 (EMBL:AL162755) (259 aa) fasta scores: E(): 6.9e-08, 27.23% id in 235 aa; hypothetical protein 1505202 2650368 DIP1483 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939831.1 1504456 D 257309 CDS NP_939832.1 38234065 2650369 complement(1505222..1506031) 1 NC_002935.2 Similar to Propionibacterium freudenreichii shermanii uroporphyrinogen III methyltransferase CobA TR:Q51720 (EMBL:U13043) (257 aa) fasta scores: E(): 1.6e-37, 47.05% id in 238 aa, and to Bacillus megaterium uroporphyrinogen III methylase CysGA TR:O87699 (EMBL:AJ000758) (243 aa) fasta scores: E(): 4.5e-32, 44.58% id in 240 aa; uroporphyrinogen III methyltransferase 1506031 2650369 DIP1484 Corynebacterium diphtheriae NCTC 13129 uroporphyrinogen III methyltransferase NP_939832.1 1505222 R 257309 CDS NP_939833.1 38234066 2650370 1506045..1507391 1 NC_002935.2 Similar to Bacillus halodurans BH3939 protein TR:Q9K5Z6 (EMBL:AP001520) (492 aa) fasta scores: E(): 6.3e-56, 41.8% id in 488 aa, and to Rhizobium meliloti hypothetical protein SMC00453 TR:CAC45554 (EMBL:AL591785) (490 aa) fasta scores: E(): 9.8e-55, 40.53% id in 491 aa; hypothetical protein 1507391 2650370 DIP1485 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939833.1 1506045 D 257309 CDS NP_939834.1 38234067 2650371 complement(1507395..1508519) 1 NC_002935.2 Similar to Staphylococcus aureus (strain N315) hypothetical protein SA0410 or SAV0450 TR:BAB56612 (EMBL:AP003130) (400 aa) fasta scores: E(): 4.2e-50, 48.16% id in 326 aa, and to Pseudomonas denitrificans CobW protein SW:COBW_PSEDE (P29937) (353 aa) fasta scores: E(): 1.1e-19, 29.22% id in 349 aa; cobalamin synthesis-like protein 1508519 2650371 DIP1486 Corynebacterium diphtheriae NCTC 13129 cobalamin synthesis-like protein NP_939834.1 1507395 R 257309 CDS NP_939835.1 38234068 2650372 complement(1508539..1509048) 1 NC_002935.2 Similar to Escherichia coli methylated-DNA--protein-cysteine methyltransferase Ogt or B1335 SW:OGT_ECOLI (P09168) (171 aa) fasta scores: E(): 8.7e-12, 32.7% id in 159 aa, and to Salmonella typhimurium methylated-DNA--protein-cysteine methyltransferase Ogt or STM1659 or STY1405 SW:OGT_SALTY (P37429) (171 aa) fasta scores: E(): 1e-10, 31.44% id in 159 aa; DNA repair-like protein 1509048 2650372 DIP1487 Corynebacterium diphtheriae NCTC 13129 DNA repair-like protein NP_939835.1 1508539 R 257309 CDS NP_939836.2 161598673 2650373 complement(1509038..1510417) 1 NC_002935.2 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid; cobyrinic acid a,c-diamide synthase 1510417 2650373 DIP1488 Corynebacterium diphtheriae NCTC 13129 cobyrinic acid a,c-diamide synthase NP_939836.2 1509038 R 257309 CDS NP_939837.1 38234070 2650374 complement(1510411..1511031) 1 NC_002935.2 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 1511031 2650374 DIP1489 Corynebacterium diphtheriae NCTC 13129 cob(I)yrinic acid a,c-diamide adenosyltransferase NP_939837.1 1510411 R 257309 CDS NP_939838.1 38234071 2650376 complement(1513204..1514703) 1 NC_002935.2 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 1514703 mqo 2650376 mqo Corynebacterium diphtheriae NCTC 13129 malate:quinone oxidoreductase NP_939838.1 1513204 R 257309 CDS NP_939839.1 38234072 2650377 1515080..1516093 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 hypothetical 38.2 kDa protein MT2921 TR:AAK47246 (EMBL:AE007116) (346 aa) fasta scores: E(): 5.6e-43, 40.95% id in 337 aa; hypothetical protein 1516093 2650377 DIP1493 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939839.1 1515080 D 257309 CDS NP_939840.1 38234073 2650378 1516191..1517582 1 NC_002935.2 catalyzes the reduction of mycothione or glutathione to mycothione or glutathione disulfide; mycothione reductase 1517582 2650378 DIP1494 Corynebacterium diphtheriae NCTC 13129 mycothione reductase NP_939840.1 1516191 D 257309 CDS NP_939841.1 38234074 2650379 complement(1517640..1519079) 1 NC_002935.2 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation; cobyric acid synthase 1519079 cobQ 2650379 cobQ Corynebacterium diphtheriae NCTC 13129 cobyric acid synthase NP_939841.1 1517640 R 257309 CDS NP_939842.1 38234075 2650380 complement(1519142..1520026) 1 NC_002935.2 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential; methionine aminopeptidase 1520026 mapB 2650380 mapB Corynebacterium diphtheriae NCTC 13129 methionine aminopeptidase NP_939842.1 1519142 R 257309 CDS NP_939843.1 38234076 2650381 complement(1520073..1521929) 1 NC_002935.2 Similar to Mycobacterium tuberculosis penecillin binding protein Rv2864c or MTV003.10c TR:O33346 (EMBL:AL008883) (603 aa) fasta scores: E(): 1.9e-81, 42.81% id in 612 aa, and to Staphylococcus aureus beta-lactam-inducible penicillin-binding protein Pbp SW:PBP_STAAU (P07944) (670 aa) fasta scores: E(): 2.3e-07, 21.04% id in 632 aa; secreted penicillin-binding protein 1521929 2650381 DIP1497 Corynebacterium diphtheriae NCTC 13129 secreted penicillin-binding protein NP_939843.1 1520073 R 257309 CDS NP_939844.1 38234077 2650382 complement(1522046..1523221) 1 NC_002935.2 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 1523221 ispG 2650382 ispG Corynebacterium diphtheriae NCTC 13129 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase NP_939844.1 1522046 R 257309 CDS NP_939845.1 38234078 2650383 complement(1523327..1524541) 1 NC_002935.2 Similar to Mycobacterium leprae probable integral membrane protein ML1582 TR:Q9CBU4 (EMBL:AL583922) (404 aa) fasta scores: E(): 1.1e-60, 42.71% id in 405 aa; hypothetical protein 1524541 2650383 DIP1499 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939845.1 1523327 R 257309 CDS NP_939846.1 38234079 2650384 complement(1524586..1525749) 1 NC_002935.2 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1525749 dxr 2650384 dxr Corynebacterium diphtheriae NCTC 13129 1-deoxy-D-xylulose 5-phosphate reductoisomerase NP_939846.1 1524586 R 257309 CDS NP_939847.1 38234080 2650385 1525987..1526505 1 NC_002935.2 hypothetical protein 1526505 2650385 DIP1501 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939847.1 1525987 D 257309 CDS NP_939848.1 38234081 2650386 complement(1526585..1527691) 1 NC_002935.2 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 1527691 2650386 DIP1502 Corynebacterium diphtheriae NCTC 13129 ribosomal RNA large subunit methyltransferase N NP_939848.1 1526585 R 257309 CDS NP_939849.1 38234082 2650387 1527861..1528244 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3867 TR:AAK48231 (EMBL:AE007181) (117 aa) fasta scores: E(): 1.1e-09, 47.25% id in 91 aa; hypothetical protein 1528244 2650387 DIP1503 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939849.1 1527861 D 257309 CDS NP_939850.1 38234083 2650388 complement(1528307..1529185) 1 NC_002935.2 Similar to Mycobacterium tuberculosis phosphatidate cytidylyltransferase CdsA or Rv2881c or MT2948 or MTCY274.12c SW:CDSA_MYCTU (Q10807) (306 aa) fasta scores: E(): 2.4e-51, 51.73% id in 288 aa, and to Escherichia coli phosphatidate cytidylyltransferase CdsA or Cds or B0175 or Z0186 or ECS0177 SW:CDSA_ECOLI (P06466) (249 aa) fasta scores: E(): 1.9e-14, 35.35% id in 198 aa; phospholipid biosynthesis 1529185 2650388 DIP1504 Corynebacterium diphtheriae NCTC 13129 phospholipid biosynthesis NP_939850.1 1528307 R 257309 CDS NP_939851.1 38234084 2650389 complement(1529309..1529866) 1 NC_002935.2 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 1529866 frr 2650389 frr Corynebacterium diphtheriae NCTC 13129 ribosome recycling factor NP_939851.1 1529309 R 257309 CDS NP_939852.1 38234085 2650390 complement(1529938..1530747) 1 NC_002935.2 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 1530747 pyrH 2650390 pyrH Corynebacterium diphtheriae NCTC 13129 uridylate kinase NP_939852.1 1529938 R 257309 CDS NP_939853.1 38234086 2650391 complement(1530890..1531717) 1 NC_002935.2 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 1531717 tsf 2650391 tsf Corynebacterium diphtheriae NCTC 13129 elongation factor Ts NP_939853.1 1530890 R 257309 CDS NP_939854.1 38234087 2650392 complement(1531998..1532798) 1 NC_002935.2 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 1532798 rpsB 2650392 rpsB Corynebacterium diphtheriae NCTC 13129 30S ribosomal protein S2 NP_939854.1 1531998 R 257309 CDS NP_939855.1 38234088 2650393 1533166..1533699 1 NC_002935.2 Similar to the N-terminal region of Mycobacterium tuberculosis hypothetical 25.8 kDa protein Rv2891 precursor or MT2958.2 or MTCY274.22 SW:YS91_MYCTU (Q10812) (249 aa) fasta scores: E(): 2.1e-14, 39.05% id in 169 aa; hypothetical protein 1533699 2650393 DIP1509 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939855.1 1533166 D 257309 CDS NP_939856.1 38234089 2650394 complement(1533714..1534622) 1 NC_002935.2 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 1534622 xerC 2650394 xerC Corynebacterium diphtheriae NCTC 13129 site-specific tyrosine recombinase XerC NP_939856.1 1533714 R 257309 CDS NP_939857.1 38234090 2650395 complement(1534889..1536040) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 40.1 kDa protein Rv2896c or MT2964 or MTCY274.27C SW:YS96_MYCTU (Q10817) (389 aa) fasta scores: E(): 3.5e-42, 42.21% id in 379 aa; hypothetical protein 1536040 2650395 DIP1511 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939857.1 1534889 R 257309 CDS NP_939858.1 38234091 2650396 complement(1536037..1537587) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 52.9 kDa protein Rv2897c or MT2965 or MTCY274.28C SW:YS97_MYCTU (Q10818) (503 aa) fasta scores: E(): 8.8e-58, 45.63% id in 515 aa, and to Haemophilus influenzae competence protein ComM or HI1117 SW:COMM_HAEIN (P45049) (509 aa) fasta scores: E(): 3.5e-49, 36.59% id in 511 aa; hypothetical protein 1537587 2650396 DIP1512 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939858.1 1536037 R 257309 CDS NP_939859.1 38234092 2650397 complement(1537574..1538101) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical protein SC2E1.19 SW:YE19_STRCO (O69890) (130 aa) fasta scores: E(): 2.6e-05, 32.54% id in 126 aa; hypothetical protein 1538101 2650397 DIP1513 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939859.1 1537574 R 257309 CDS NP_939860.1 38234093 2650398 complement(1538173..1538478) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 12.2 kDa protein Rv2901c or MT2969 or MTCY274.32c SW:YT01_MYCTU (Q10822) (101 aa) fasta scores: E(): 3.7e-31, 70.29% id in 101 aa, and to Streptomyces coelicolor hypothetical 12.3 kDa protein SC2E1.18 TR:O69889 (EMBL:AL023797) (102 aa) fasta scores: E(): 2.9e-27, 67% id in 100 aa; hypothetical protein 1538478 2650398 DIP1514 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939860.1 1538173 R 257309 CDS NP_939861.1 38234094 2650399 complement(1538491..1539180) 1 NC_002935.2 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1539180 rnhB 2650399 rnhB Corynebacterium diphtheriae NCTC 13129 ribonuclease HII NP_939861.1 1538491 R 257309 CDS NP_939862.1 38234095 2650400 complement(1539177..1540034) 1 NC_002935.2 Similar to Mycobacterium tuberculosis probable signal peptidase I LepB or Rv2903c or MT2971 or MTCY274.34C SW:LEP_MYCTU (Q10789) (294 aa) fasta scores: E(): 3.3e-40, 44.18% id in 258 aa, and to Bacillus licheniformis signal peptidase I Sip SW:LEP_BACLI (P42668) (186 aa) fasta scores: E(): 5.7e-08, 30.56% id in 229 aa; signal peptidase 1540034 2650400 DIP1516 Corynebacterium diphtheriae NCTC 13129 signal peptidase NP_939862.1 1539177 R 257309 CDS NP_939863.1 38234096 2650401 complement(1540598..1541410) 1 NC_002935.2 Similar to Escherichia coli transposase InsK for insertion sequence element IS150 or B3558 SW:INSK_ECOLI (P19769) (283 aa) fasta scores: E(): 2.3e-44, 45.62% id in 263 aa. Identical to DIP0434, DIP1526, DIP1809 and DIP2123; transposase 1541410 2650401 DIP1517 Corynebacterium diphtheriae NCTC 13129 transposase NP_939863.1 1540598 R 257309 CDS NP_939864.1 38234097 2650402 complement(1541458..1541940) 1 NC_002935.2 Similar to Streptococcus pneumoniae hypothetical 20.7 kDa protein TR:Q9KK22 (EMBL:AF154034) (171 aa) fasta scores: E(): 1.3e-08, 33.75% id in 157 aa, and to Yersinia pestis insertion element IS1661 DNA-binding protein YPO4046 TR:CAC93502 (EMBL:AJ414160) (171 aa) fasta scores: E(): 0.00044, 25.45% id in 165 aa. Identical to DIP0435, DIP1525, DIP1808 and DIP2124; insertion element DNA-binding protein 1541940 2650402 DIP1518 Corynebacterium diphtheriae NCTC 13129 insertion element DNA-binding protein NP_939864.1 1541458 R 257309 CDS NP_939865.1 38234098 2650403 complement(1542092..1543009) 1 NC_002935.2 Similar to Corynebacterium diphtheriae secreted protein precursor TR:Q9XD85 (EMBL:AF109162) (339 aa) fasta scores: E(): 2.7e-34, 42.4% id in 250 aa; hypothetical protein 1543009 2650403 DIP1519 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939865.1 1542092 R 257309 CDS NP_939866.1 38234099 2650404 complement(1543197..1545506) 1 NC_002935.2 hypothetical protein 1545506 2650404 DIP1520 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939866.1 1543197 R 257309 CDS NP_939867.1 38234100 2650405 complement(1545659..1545772) 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 1545772 2650405 DIP1521 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939867.1 1545659 R 257309 CDS NP_939868.1 38234101 2650406 complement(1545949..1546185) 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 1546185 2650406 DIP1522 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939868.1 1545949 R 257309 CDS NP_939869.1 38234102 2649122 1547110..1547592 1 NC_002935.2 Similar to Streptococcus pneumoniae hypothetical 20.7 kDa protein TR:Q9KK22 (EMBL:AF154034) (171 aa) fasta scores: E(): 1.3e-08, 33.75% id in 157 aa, and to Yersinia pestis insertion element ISs1661 DNA-binding protein YPO4091 TR:CAC93541 (EMBL:AJ414160) (171 aa) fasta scores: E(): 0.00044, 25.45% id in 165 aa. Identical to DIP0435, DIP1518, DIP1808 and DIP2124; insertion element DNA-binding protein 1547592 2649122 DIP1525 Corynebacterium diphtheriae NCTC 13129 insertion element DNA-binding protein NP_939869.1 1547110 D 257309 CDS NP_939870.1 38234103 2650716 1547640..1548452 1 NC_002935.2 Similar to Escherichia coli transposase InsK for insertion sequence element IS150 or B3558 SW:INSK_ECOLI (P19769) (283 aa) fasta scores: E(): 2.3e-44, 45.62% id in 263 aa. Identical to DIP0434, DIP1517, DIP1809 and DIP2123; transposase 1548452 2650716 DIP1526 Corynebacterium diphtheriae NCTC 13129 transposase NP_939870.1 1547640 D 257309 CDS NP_939871.1 38234104 2650717 complement(1548534..1548875) 1 NC_002935.2 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 1548875 rplS 2650717 rplS Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L19 NP_939871.1 1548534 R 257309 CDS NP_939872.1 38234105 2650718 complement(1549049..1551325) 1 NC_002935.2 Similar to Streptomyces coelicolor transcriptional accessory protein SC5F2A.26c TR:Q9X7P9 (EMBL:AL049587) (780 aa) fasta scores: E(): 8.5e-161, 59.94% id in 774 aa, and to Escherichia coli protein YhgF or B3407 SW:YHGF_ECOLI (P46837) (773 aa) fasta scores: E(): 7.3e-153, 57.44% id in 766 aa; transcriptional accessory protein 1551325 2650718 DIP1528 Corynebacterium diphtheriae NCTC 13129 transcriptional accessory protein NP_939872.1 1549049 R 257309 CDS NP_939873.1 38234106 2650719 complement(1551351..1551719) 1 NC_002935.2 hypothetical protein 1551719 2650719 DIP1529 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939873.1 1551351 R 257309 CDS NP_939874.1 38234107 2650720 complement(1551703..1552581) 1 NC_002935.2 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 1552581 trmD 2650720 trmD Corynebacterium diphtheriae NCTC 13129 tRNA (guanine-N(1)-)-methyltransferase NP_939874.1 1551703 R 257309 CDS NP_939875.1 38234108 2650721 complement(1552581..1553081) 1 NC_002935.2 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 1553081 rimM 2650721 rimM Corynebacterium diphtheriae NCTC 13129 16S rRNA-processing protein RimM NP_939875.1 1552581 R 257309 CDS NP_939876.1 38234109 2650722 complement(1553211..1553684) 1 NC_002935.2 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 1553684 rpsP 2650722 rpsP Corynebacterium diphtheriae NCTC 13129 30S ribosomal protein S16 NP_939876.1 1553211 R 257309 CDS NP_939877.1 38234110 2650723 complement(1553918..1555534) 1 NC_002935.2 Similar to Mycobacterium tuberculosis signal recognition particle protein Ffh or Rv2916c or MT2984 or MTCY338.04c SW:SR54_MYCTU (Q10963) (525 aa) fasta scores: E(): 2e-110, 66.6% id in 542 aa, and to Bacillus subtilis signal recognition particle protein Ffh SW:SR54_BACSU (P37105) (446 aa) fasta scores: E(): 3.2e-43, 51.52% id in 458 aa, and to Escherichia coli signal recognition particle protein Ffh or B2610 or Z3904 or ECS3473 SW:SR54_ECOLI (P07019) (453 aa) fasta scores: E(): 2.6e-38, 46.36% id in 468 aa; signal recognition particle protein 1555534 ffh 2650723 ffh Corynebacterium diphtheriae NCTC 13129 signal recognition particle protein NP_939877.1 1553918 R 257309 CDS NP_939878.1 38234111 2650724 complement(1555644..1557803) 1 NC_002935.2 Uridylylates and de-uridylylates the small trimeric protein Pii; PII uridylyl-transferase 1557803 glnD 2650724 glnD Corynebacterium diphtheriae NCTC 13129 PII uridylyl-transferase NP_939878.1 1555644 R 257309 CDS NP_939879.1 38234112 2650725 complement(1557809..1558147) 1 NC_002935.2 Similar to Corynebacterium glutamicum PII protein GlnB TR:Q9X705 (EMBL:AJ010319) (112 aa) fasta scores: E(): 3.4e-31, 73.21% id in 112 aa, and to Azospirillum brasilense nitrogen regulatory protein P-II GlnB SW:GLNB_AZOBR (P21193) (112 aa) fasta scores: E(): 5.2e-25, 57.14% id in 112 aa, and to Escherichia coli nitrogen regulatory protein P-II 1 GlnB or B2553 or Z3829 or ECS3419 or STY2808 SW:GLNB_ECOLI (P05826) (112 aa) fasta scores: E(): 2e-24, 59.82% id in 112 aa; nitrogen regulatory protein 1558147 glnB 2650725 glnB Corynebacterium diphtheriae NCTC 13129 nitrogen regulatory protein NP_939879.1 1557809 R 257309 CDS NP_939880.1 38234113 2650727 complement(1559123..1560610) 1 NC_002935.2 Similar to Salmonella enterica subsp. enterica serovar Typhi cell division protein FtsY TR:CAD08059 (EMBL:AL627281) (491 aa) fasta scores: E(): 5e-39, 35.58% id in 503 aa, and to Escherichia coli cell division protein FtsY or B3464 SW:FTSY_ECOLI (P10121) (497 aa) fasta scores: E(): 2.6e-38, 35.79% id in 500 aa; cell division protein 1560610 2650727 DIP1538 Corynebacterium diphtheriae NCTC 13129 cell division protein NP_939880.1 1559123 R 257309 CDS NP_939881.1 38234114 2650728 complement(1560748..1564308) 1 NC_002935.2 No significant database matches. High content in alanine, leucine and valine amino acid residues Low G+C content (52.14%); hypothetical protein 1564308 2650728 DIP1539 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939881.1 1560748 R 257309 CDS NP_939882.1 38234115 2650729 complement(1564413..1567898) 1 NC_002935.2 Similar to Mycobacterium leprae chromosome partition protein Smc or ML1629 or MLCB250.01 SW:SMC_MYCLE (Q9CBT5) (1203 aa) fasta scores: E(): 1.4e-70, 46.09% id in 1191 aa, and to Bacillus subtilis chromosome partition protein Smc SW:SMC_BACSU (P51834) (1186 aa) fasta scores: E(): 2.1e-34, 28.92% id in 1217 aa. Note: Contains various possible colied-coil regions throughout the whole length of the CDS; chromosome partition protein 1567898 2650729 DIP1540 Corynebacterium diphtheriae NCTC 13129 chromosome partition protein NP_939882.1 1564413 R 257309 CDS NP_939883.1 38234116 2650730 complement(1567923..1568210) 1 NC_002935.2 Similar to Mycobacterium tuberculosis acylphosphatase Rv2922.1c or MT2991 or MTCY338.11bc SW:ACYP_MYCTU (P56543) (93 aa) fasta scores: E(): 1.3e-14, 52.08% id in 96 aa, and to Escherichia coli acylphosphatase YccX or B0968 or Z1320 or ECS1052 SW:ACYP_ECOLI (P75877) (92 aa) fasta scores: E(): 1.2e-07, 43.82% id in 89 aa; acylphosphatase 1568210 2650730 DIP1541 Corynebacterium diphtheriae NCTC 13129 acylphosphatase NP_939883.1 1567923 R 257309 CDS NP_939884.1 38234117 2650731 complement(1568210..1569697) 1 NC_002935.2 Similar to Staphylococcus aureus (strain N315) amino acid carrier protein AlsT or SA1190 or SAV1356 TR:BAB57518 (EMBL:AP003133) (486 aa) fasta scores: E(): 5.8e-84, 48.83% id in 473 aa, and to Bacillus subtilis amino acid carrier protein AlsT SW:ALST_BACSU (Q45068) (465 aa) fasta scores: E(): 1.3e-73, 46.18% id in 472 aa; amino acid carrier protein 1569697 2650731 DIP1542 Corynebacterium diphtheriae NCTC 13129 amino acid carrier protein NP_939884.1 1568210 R 257309 CDS NP_939885.1 38234118 2650732 complement(1569776..1570666) 1 NC_002935.2 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 1570666 2650732 DIP1543 Corynebacterium diphtheriae NCTC 13129 formamidopyrimidine-DNA glycosylase NP_939885.1 1569776 R 257309 CDS NP_939886.1 38234119 2650733 complement(1570684..1571433) 1 NC_002935.2 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 1571433 rnc 2650733 rnc Corynebacterium diphtheriae NCTC 13129 ribonuclease III NP_939886.1 1570684 R 257309 CDS NP_939887.1 38234120 2650734 complement(1571430..1571960) 1 NC_002935.2 Similar to the C-terminal region of Mycobacterium tuberculosis hypothetical 22.4 kDa protein Rrv2926c or MT2996 or MTCY338.15c SW:YT26_MYCTU (Q10972) (207 aa) fasta scores: E(): 9.5e-13, 30.46% id in 174 aa; hypothetical protein 1571960 2650734 DIP1545 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939887.1 1571430 R 257309 CDS NP_939888.1 38234121 2650735 complement(1572001..1572714) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 27.0 kDa protein Rv2927c or MT2997 or MTCY338.16c SW:YT27_MYCTU (Q10973) (245 aa) fasta scores: E(): 9e-21, 47.89% id in 238 aa; hypothetical protein 1572714 2650735 DIP1546 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939888.1 1572001 R 257309 CDS NP_939889.1 38234122 2650736 complement(1572978..1574324) 1 NC_002935.2 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1574324 gdh 2650736 gdh Corynebacterium diphtheriae NCTC 13129 glutamate dehydrogenase NP_939889.1 1572978 R 257309 CDS NP_939890.1 38234123 2650737 1574742..1575908 1 NC_002935.2 Similar to Bacillus halodurans glycerate kinase GlxK or BH0555 SW:GRK_BACHD (Q9Z9P2) (380 aa) fasta scores: E(): 1e-29, 35.14% id in 350 aa, and to Bacillus subtilis glycerate kinase GlxK or S14A SW:GRK_BACSU (P42100) (382 aa) fasta scores: E(): 7.1e-28, 32.4% id in 395 aa, and to Escherichia coli glycerate kinase 1 GlxK or GlxB5 or B0514 SW:GRK1_ECOLI (P77364) (381 aa) fasta scores: E(): 7.6e-25, 33.93% id in 333 aa; glycerate kinase 1575908 2650737 DIP1548 Corynebacterium diphtheriae NCTC 13129 glycerate kinase NP_939890.1 1574742 D 257309 CDS NP_939891.1 38234124 2650738 complement(1575878..1576306) 1 NC_002935.2 hypothetical protein 1576306 2650738 DIP1549 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939891.1 1575878 R 257309 CDS NP_939892.1 38234125 2650739 1576350..1577666 1 NC_002935.2 hypothetical protein 1577666 2650739 DIP1550 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939892.1 1576350 D 257309 CDS NP_939893.1 38234126 2650740 1577710..1579014 1 NC_002935.2 Similar to Streptomyces coelicolor peptidase SCD17.07c TR:Q9RKM4 (EMBL:AL118515) (423 aa) fasta scores: E(): 6.6e-71, 45.3% id in 415 aa, and to Thermoplasma volcanium carboxypeptidase TVG0758219 TR:BAB59893 (EMBL:AP000993) (404 aa) fasta scores: E(): 2.1e-34, 34.03% id in 379 aa; peptidase 1579014 2650740 DIP1551 Corynebacterium diphtheriae NCTC 13129 peptidase NP_939893.1 1577710 D 257309 CDS NP_939894.1 38234127 2650741 1579137..1581566 1 NC_002935.2 Similar to Escherichia coli maltodextrin phosphorylase MalP or B3417 SW:PHSM_ECOLI (P00490) (796 aa) fasta scores: E(): 5.5e-100, 44.48% id in 780 aa, and to Bacillus subtilis glycogen phosphorylase GlgP SW:PHSG_BACSU (P39123) (798 aa) fasta scores: E(): 1.2e-98, 45.43% id in 777 aa; glycogen phosphorylase 1581566 2650741 DIP1552 Corynebacterium diphtheriae NCTC 13129 glycogen phosphorylase NP_939894.1 1579137 D 257309 CDS NP_939895.1 38234128 2650742 complement(1581632..1583053) 1 NC_002935.2 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1583053 pyk 2650742 pyk Corynebacterium diphtheriae NCTC 13129 pyruvate kinase NP_939895.1 1581632 R 257309 CDS NP_939896.1 38234129 2650743 complement(1583263..1584114) 1 NC_002935.2 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 1584114 2650743 DIP1554 Corynebacterium diphtheriae NCTC 13129 prolipoprotein diacylglyceryl transferase NP_939896.1 1583263 R 257309 CDS NP_939897.1 38234130 2650744 complement(1584186..1584998) 1 NC_002935.2 Similar to Mycobacterium tuberculosis indole-3-glycerol phosphate synthase TrpC or Rv1611 or MT1646 or MTCY01B2.03 SW:TRPC_MYCTU (O06129) (272 aa) fasta scores: E(): 1.4e-52, 55.59% id in 268 aa, and to Streptomyces coelicolor indole-3-glycerol phosphate synthase 1 TrpC1 or TrpC or SC4G6.08c SW:TRC1_STRCO (O68814) (269 aa) fasta scores: E(): 1.1e-44, 48.28% id in 263 aa; indole-3-glycerol phosphate synthase 1584998 trpC2 2650744 trpC2 Corynebacterium diphtheriae NCTC 13129 indole-3-glycerol phosphate synthase NP_939897.1 1584186 R 257309 CDS NP_939898.1 38234131 2650745 complement(1585111..1585686) 1 NC_002935.2 Low similarity to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT1645 TR:AAK45914 (EMBL:AE007029) (235 aa) fasta scores: E(): 1e-08, 28.64% id in 206 aa; hypothetical protein 1585686 2650745 DIP1556 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939898.1 1585111 R 257309 CDS NP_939899.1 38234132 2650746 complement(1585787..1586137) 1 NC_002935.2 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers; phosphoribosyl-AMP cyclohydrolase 1586137 hisI 2650746 hisI Corynebacterium diphtheriae NCTC 13129 phosphoribosyl-AMP cyclohydrolase NP_939899.1 1585787 R 257309 CDS NP_939900.1 38234133 2650747 complement(1586159..1586935) 1 NC_002935.2 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 1586935 hisF 2650747 hisF Corynebacterium diphtheriae NCTC 13129 imidazole glycerol phosphate synthase subunit HisF NP_939900.1 1586159 R 257309 CDS NP_939901.1 38234134 2650748 complement(1587026..1587811) 1 NC_002935.2 Similar to Corynebacterium glutamicum inositol monophosphate phosphatase ImpA TR:O52736 (EMBL:AF045998) (259 aa) fasta scores: E(): 3.2e-42, 50.42% id in 236 aa, and to Mycobacterium smegmatis inositol monophosphate phosphatase ImpA TR:O51845 (EMBL:AF005905) (276 aa) fasta scores: E(): 8e-34, 42.35% id in 255 aa; inositol monophosphatase 1587811 impA 2650748 impA Corynebacterium diphtheriae NCTC 13129 inositol monophosphatase NP_939901.1 1587026 R 257309 CDS NP_939902.1 38234135 2650749 complement(1587808..1588536) 1 NC_002935.2 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis; phosphoribosyl isomerase A 1588536 hisA 2650749 hisA Corynebacterium diphtheriae NCTC 13129 phosphoribosyl isomerase A NP_939902.1 1587808 R 257309 CDS NP_939903.1 38234136 2650750 complement(1588634..1589266) 1 NC_002935.2 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 1589266 hisH 2650750 hisH Corynebacterium diphtheriae NCTC 13129 imidazole glycerol phosphate synthase subunit HisH NP_939903.1 1588634 R 257309 CDS NP_939904.1 38234137 2650751 complement(1589333..1590745) 1 NC_002935.2 Similar to Streptomyces coelicolor transmembrane transport protein SC5G9.26c TR:Q9RL01 (EMBL:AL117385) (420 aa) fasta scores: E(): 8e-11, 28.37% id in 437 aa, and to Streptomyces lipmanii puromycin resistance protein Pur8 SW:PUR8_STRLP (P42670) (503 aa) fasta scores: E(): 2.4e-08, 24.39% id in 455 aa; transport membrane protein 1590745 2650751 DIP1562 Corynebacterium diphtheriae NCTC 13129 transport membrane protein NP_939904.1 1589333 R 257309 CDS NP_939905.1 38234138 2650752 complement(1590914..1591129) 1 NC_002935.2 hypothetical protein 1591129 2650752 DIP1563 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939905.1 1590914 R 257309 CDS NP_939906.1 38234139 2650753 complement(1591132..1591740) 1 NC_002935.2 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase 1591740 hisB 2650753 hisB Corynebacterium diphtheriae NCTC 13129 imidazoleglycerol-phosphate dehydratase NP_939906.1 1591132 R 257309 CDS NP_939907.1 38234140 2650754 complement(1591822..1592922) 1 NC_002935.2 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 1592922 hisC 2650754 hisC Corynebacterium diphtheriae NCTC 13129 histidinol-phosphate aminotransferase NP_939907.1 1591822 R 257309 CDS NP_939908.1 38234141 2650755 complement(1592961..1594310) 1 NC_002935.2 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 1594310 hisD 2650755 hisD Corynebacterium diphtheriae NCTC 13129 histidinol dehydrogenase NP_939908.1 1592961 R 257309 CDS NP_939909.1 38234142 2650756 1594635..1595690 1 NC_002935.2 hypothetical protein 1595690 2650756 DIP1567 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939909.1 1594635 D 257309 CDS NP_939910.1 38234143 2650757 1595728..1595955 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 1595955 2650757 DIP1568 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939910.1 1595728 D 257309 CDS NP_939911.1 38234144 2650758 1595969..1596226 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 1596226 2650758 DIP1569 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939911.1 1595969 D 257309 CDS NP_939912.1 38234145 2650759 complement(1596430..1597092) 1 NC_002935.2 hypothetical protein 1597092 2650759 DIP1570 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939912.1 1596430 R 257309 CDS NP_939913.1 38234146 2650760 1597317..1597862 1 NC_002935.2 Similar to Escherichia coli tetracycline repressor protein class D TetR SW:TER4_ECOLI (P09164) (217 aa) fasta scores: E(): 8.1e-09, 30.48% id in 187 aa, and to Pasteurella piscicida tetracycline repressor protein class H TetR SW:TER8_PASPI (P51562) (218 aa) fasta scores: E(): 8.1e-09, 30.48% id in 187 aa; TetR family transcriptional regulator 1597862 2650760 DIP1571 Corynebacterium diphtheriae NCTC 13129 TetR family transcriptional regulator NP_939913.1 1597317 D 257309 CDS NP_939914.1 38234147 2650761 1597883..1600090 1 NC_002935.2 Similar to Mycobacterium tuberculosis glycogen operon protein GlgX homolog or Rv1564c or MT1615 or MTCY48.01 SW:GLGX_MYCTU (Q10767) (721 aa) fasta scores: E(): 5.5e-205, 69.12% id in 706 aa, and to Escherichia coli glycogen operon protein GlgX or GlyX or B3431 SW:GLGX_ECOLI (P15067) (657 aa) fasta scores: E(): 8.1e-87, 46.38% id in 664 aa; hypothetical protein 1600090 glgX 2650761 glgX Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939914.1 1597883 D 257309 CDS NP_939915.1 38234148 2650762 1600226..1601572 1 NC_002935.2 Similar to Clostridium acetobutylicum DNA polymerase III epsilon subunit CAC0738 TR:AAK78714 (EMBL:AE007589) (306 aa) fasta scores: E(): 1.4e-14, 28.9% id in 339 aa, and to the exonuclease domain of Bacillus halodurans DNA polymerase III PolC-type PolC or BH2418 SW:DPO3_BACHD (Q9KA72) (1433 aa) fasta scores: E(): 2.7e-08, 28.62% id in 248 aa; DNA polymerase III subunit epsilon 1601572 2650762 DIP1573 Corynebacterium diphtheriae NCTC 13129 DNA polymerase III subunit epsilon NP_939915.1 1600226 D 257309 CDS NP_939916.1 38234149 2650763 1601707..1602324 1 NC_002935.2 hypothetical protein 1602324 2650763 DIP1574 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939916.1 1601707 D 257309 CDS NP_939917.1 38234150 2650764 1602408..1603427 1 NC_002935.2 Similar to N-terminal region of Deinococcus radiodurans conserved hypothetical protein DRr1631 TR:Q9RTX1 (EMBL:AE002006) (394 aa) fasta scores: E(): 4.7e-12, 31.28% id in 211 aa; hypothetical protein 1603427 2650764 DIP1575 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939917.1 1602408 D 257309 CDS NP_939918.1 38234151 2650765 complement(1603691..1604068) 1 NC_002935.2 Similar to Rhizobium loti MLR3853 protein TR:Q98FB3 (EMBL:AP003002) (131 aa) fasta scores: E(): 2.9e-09, 42.01% id in 119 aa, and to Escherichia coli heat shock protein 15 HslR or B3400 or Z4754 or ECS4242 SW:HSLR_ECOLI (P45802) (133 aa) fasta scores: E(): 2.7e-06, 32.54% id in 126 aa; RNA-binding heat shock protein 1604068 2650765 DIP1576 Corynebacterium diphtheriae NCTC 13129 RNA-binding heat shock protein NP_939918.1 1603691 R 257309 CDS NP_939919.1 38234152 2650766 complement(1604074..1604304) 1 NC_002935.2 hypothetical protein 1604304 2650766 DIP1577 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939919.1 1604074 R 257309 CDS NP_939920.1 38234153 2650767 complement(1604330..1604971) 1 NC_002935.2 Similar to Bacillus subtilis hypothetical 24.8 kDa protein in degS-tagO intergenic region YvyE or YvhK SW:YVYE_BACSU (P32437) (217 aa) fasta scores: E(): 1.3e-24, 37.5% id in 208 aa; hypothetical protein 1604971 2650767 DIP1578 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939920.1 1604330 R 257309 CDS NP_939921.1 38234154 2650768 complement(1604995..1606335) 1 NC_002935.2 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 1606335 ilvA 2650768 ilvA Corynebacterium diphtheriae NCTC 13129 threonine dehydratase NP_939921.1 1604995 R 257309 CDS NP_939922.1 38234155 2650769 complement(1606336..1609896) 1 NC_002935.2 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 1609896 dnaE 2650769 dnaE Corynebacterium diphtheriae NCTC 13129 DNA polymerase III subunit alpha NP_939922.1 1606336 R 257309 CDS NP_939923.1 38234156 2650770 1610019..1610918 1 NC_002935.2 Similar to Streptomyces coelicolor integral membrane protein SCD20.10c TR:Q9F2W9 (EMBL:AL392148) (362 aa) fasta scores: E(): 2.4e-45, 45.54% id in 292 aa; hypothetical protein 1610918 2650770 DIP1581 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939923.1 1610019 D 257309 CDS NP_939924.1 38234157 2650771 complement(1610892..1611437) 1 NC_002935.2 hypothetical protein 1611437 2650771 DIP1582 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939924.1 1610892 R 257309 CDS NP_939925.1 38234158 2650772 complement(1611445..1612371) 1 NC_002935.2 Similar to Mycobacterium leprae pseudouridine synthase RluC or ML1200 or MLCB458.15 TR:Q9X7E8 (EMBL:AL049478) (308 aa) fasta scores: E(): 1.2e-79, 68.62% id in 306 aa, and to Streptomyces coelicolor ribosomal large subunit pseudouridine synthase SC4A10.06c TR:Q9S2X8 (EMBL:AL109663) (314 aa) fasta scores: E(): 8.5e-75, 64.37% id in 306 aa; pseudouridine synthase 1612371 rluC 2650772 rluC Corynebacterium diphtheriae NCTC 13129 pseudouridine synthase NP_939925.1 1611445 R 257309 CDS NP_939926.1 38234159 2650773 complement(1612368..1612892) 1 NC_002935.2 Similar to Streptomyces coelicolor lipoprotein signal peptidase SC4A10.07c TR:Q9S2X7 (EMBL:AL109663) (204 aa) fasta scores: E(): 1e-20, 43.03% id in 165 aa, and to Bacillus subtilis lipoprotein signal peptidase LspA or Lps SW:LSPA_BACSU (Q45479) (154 aa) fasta scores: E(): 1.7e-11, 35.71% id in 154 aa; lipoprotein signal peptidase 1612892 2650773 DIP1584 Corynebacterium diphtheriae NCTC 13129 lipoprotein signal peptidase NP_939926.1 1612368 R 257309 CDS NP_939927.1 38234160 2650774 1612953..1613918 1 NC_002935.2 hypothetical protein 1613918 2650774 DIP1585 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939927.1 1612953 D 257309 CDS NP_939928.1 38234161 2650775 complement(1614007..1614627) 1 NC_002935.2 Similar to Mycobacterium tuberculosis lipoprotein LppK precursor or Rv2116 or MT2176 or MTCY261.12 SW:LPPK_MYCTU (O33251) (189 aa) fasta scores: E(): 0.0014, 30.48% id in 187 aa; hypothetical protein 1614627 2650775 DIP1586 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939928.1 1614007 R 257309 CDS NP_939929.1 38234162 2650776 1614825..1615745 1 NC_002935.2 Similar to Mycobacterium leprae probable L-asparaginase AnsA or ML1198 or MLCB458.13c SW:ASPG_MYCLE (Q9X7E6) (310 aa) fasta scores: E(): 4.7e-19, 37.65% id in 316 aa, and to Erwinia chrysanthemi L-asparaginase precursor AnsB or Asn SW:ASPG_ERWCH (P06608) (348 aa) fasta scores: E(): 3.4e-09, 29.51% id in 332 aa. Also similar to DIP0491 E(): 2e-48, 52.303% identity in 304 aa overlap; L-asparaginase 1615745 2650776 DIP1587 Corynebacterium diphtheriae NCTC 13129 L-asparaginase NP_939929.1 1614825 D 257309 CDS NP_939930.1 38234163 2650777 complement(1615746..1617101) 1 NC_002935.2 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 1617101 dinB 2650777 dinB Corynebacterium diphtheriae NCTC 13129 DNA polymerase IV NP_939930.1 1615746 R 257309 CDS NP_939931.1 38234164 2650778 complement(1617227..1620385) 1 NC_002935.2 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin); isoleucyl-tRNA synthetase 1620385 ileS 2650778 ileS Corynebacterium diphtheriae NCTC 13129 isoleucyl-tRNA synthetase NP_939931.1 1617227 R 257309 CDS NP_939932.1 38234165 2650779 complement(1620783..1621784) 1 NC_002935.2 Similar to Corynebacterium glutamicum antigen 84 Wag31 TR:Q9L4H7 (EMBL:AJ242594) (365 aa) fasta scores: E(): 1.7e-21, 60.66% id in 361 aa, and to Mycobacterium leprae antigen 84 Ag84 or ML0922 SW:AG84_MYCLE (P46815) (266 aa) fasta scores: E(): 1.8e-14, 43.97% id in 332 aa, and to Mycobacterium tuberculosis antigen 84 Ag84 or Wag31 or Rv2145c or MT2204 or MTCY270.23 SW:AG84_MYCTU (P46816) (260 aa) fasta scores: E(): 6.3e-14, 44.27% id in 332 aa. Note: Contains three colied-coil regions (residues 84..131, 193..235, 248..273); hypothetical protein 1621784 ag84 2650779 ag84 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939932.1 1620783 R 257309 CDS NP_939933.1 38234166 2650780 complement(1622125..1622412) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 10.7 kDa protein SC4A10.11c TR:Q9S2X3 (EMBL:AL109663) (94 aa) fasta scores: E(): 2.6e-09, 34.78% id in 92 aa, and to Mycobacterium leprae possible membrane protein ML0921 TR:Q9CCE0 (EMBL:AL583920) (96 aa) fasta scores: E(): 6.7e-09, 41.57% id in 89 aa; hypothetical protein 1622412 2650780 DIP1591 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939933.1 1622125 R 257309 CDS NP_939934.1 38234167 2650781 complement(1622397..1622597) 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 1622597 2650781 DIP1592 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939934.1 1622397 R 257309 CDS NP_939935.1 38234168 2650782 complement(1622609..1623058) 1 NC_002935.2 Similar to Corynebacterium glutamicum Yak1 protein TR:Q9KX18 (EMBL:Y08964) (152 aa) fasta scores: E(): 1.1e-21, 52.9% id in 155 aa, and to Streptomyces coelicolor conserved hypothetical protein 2SCI34.02 TR:Q9EWX7 (EMBL:AL445403) (146 aa) fasta scores: E(): 9.1e-07, 31.88% id in 138 aa; hypothetical protein 1623058 2650782 DIP1593 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939935.1 1622609 R 257309 CDS NP_939936.1 38234169 2650783 complement(1623168..1623908) 1 NC_002935.2 Similar to Corynebacterium glutamicum hypothetical 26.0 kDa protein in FtsZ 3'region SW:YFTZ_CORGL (P94338) (246 aa) fasta scores: E(): 6.5e-66, 68.72% id in 243 aa, and to Streptomyces griseus hypothetical 25.3 kDa protein in FtsZ 3'region SW:YFTZ_STRGR (P45496) (246 aa) fasta scores: E(): 7.4e-41, 50% id in 228 aa; hypothetical protein 1623908 2650783 DIP1594 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939936.1 1623168 R 257309 CDS NP_939937.1 38234170 2650784 complement(1623908..1625143) 1 NC_002935.2 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1625143 ftsZ 2650784 ftsZ Corynebacterium diphtheriae NCTC 13129 cell division protein FtsZ NP_939937.1 1623908 R 257309 CDS NP_939938.1 38234171 2650785 complement(1625535..1626191) 1 NC_002935.2 Similar to Corynebacterium glutamicum cell division protein homolog FtsQ or DivB SW:FTSQ_CORGL (P94336) (222 aa) fasta scores: E(): 3.3e-30, 41.36% id in 220 aa, and to Mycobacterium tuberculosis cell division protein homolog FtsQ or Rv2151c or MT2210 or MTCY270.17 SW:FTSQ_MYCTU (O06226) (314 aa) fasta scores: E(): 4e-16, 32.4% id in 216 aa; cell division protein 1626191 2650785 DIP1596 Corynebacterium diphtheriae NCTC 13129 cell division protein NP_939938.1 1625535 R 257309 CDS NP_939939.1 38234172 2650786 complement(1626188..1627621) 1 NC_002935.2 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 1627621 murC 2650786 murC Corynebacterium diphtheriae NCTC 13129 UDP-N-acetylmuramate--L-alanine ligase NP_939939.1 1626188 R 257309 CDS NP_939940.1 38234173 2650787 complement(1627639..1628718) 1 NC_002935.2 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 1628718 murG 2650787 murG Corynebacterium diphtheriae NCTC 13129 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase NP_939940.1 1627639 R 257309 CDS NP_939941.1 38234174 2650788 complement(1628720..1630228) 1 NC_002935.2 Similar to Corynebacterium glutamicum FtsW protein TR:Q9L4H4 (EMBL:AJ242646) (490 aa) fasta scores: E(): 9.6e-78, 48.85% id in 481 aa, and to Escherichia coli cell division protein FtsW or B0089 or Z0099 or ECS0093 SW:FTSW_ECOLI (P16457) (414 aa) fasta scores: E(): 1e-21, 32.53% id in 375 aa; cell division protein 1630228 2650788 DIP1599 Corynebacterium diphtheriae NCTC 13129 cell division protein NP_939941.1 1628720 R 257309 CDS NP_939942.1 38234175 2650789 complement(1630255..1631697) 1 NC_002935.2 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 1631697 murD 2650789 murD Corynebacterium diphtheriae NCTC 13129 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase NP_939942.1 1630255 R 257309 CDS NP_939943.1 38234176 2650790 complement(1631702..1632820) 1 NC_002935.2 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 1632820 mraY 2650790 mraY Corynebacterium diphtheriae NCTC 13129 phospho-N-acetylmuramoyl-pentapeptide- transferase NP_939943.1 1631702 R 257309 CDS NP_939944.1 38234177 2650791 complement(1632828..1634318) 1 NC_002935.2 Similar to Mycobacterium tuberculosis UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-- D-alanyl-D- alanyl ligase MurF or Rv2157c or MT2216 or MTCY270.11 SW:MURF_MYCTU (O06220) (510 aa) fasta scores: E(): 2.3e-75, 49.7% id in 513 aa, and to Streptomyces toyocaensis probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-- D- alanyl-D-alanyl ligase MurF or MurX SW:MURF_STRTO (O33804) (443 aa) fasta scores: E(): 3.9e-30, 40.6% id in 495 aa; UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase 1634318 murF 2650791 murF Corynebacterium diphtheriae NCTC 13129 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase NP_939944.1 1632828 R 257309 CDS NP_939945.1 38234178 2650792 complement(1634372..1635913) 1 NC_002935.2 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1635913 murE 2650792 murE Corynebacterium diphtheriae NCTC 13129 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase NP_939945.1 1634372 R 257309 CDS NP_939946.1 38234179 2650793 complement(1636021..1638045) 1 NC_002935.2 Similar to Corynebacterium glutamicum penicillin-binding protein FtsI TR:Q9FAD4 (EMBL:AB041009) (704 aa) fasta scores: E(): 3.1e-122, 59.38% id in 677 aa, and to Streptomyces coelicolor FtsI TR:Q9Z5V7 (EMBL:AF123319) (651 aa) fasta scores: E(): 2e-42, 32.24% id in 611 aa; penicillin-binding (cell division related) protein 1638045 ftsI 2650793 ftsI Corynebacterium diphtheriae NCTC 13129 penicillin-binding (cell division related) protein NP_939946.1 1636021 R 257309 CDS NP_939947.1 38234180 2650794 complement(1638076..1638849) 1 NC_002935.2 hypothetical protein 1638849 2650794 DIP1605 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939947.1 1638076 R 257309 CDS NP_939948.1 38234181 2650795 complement(1638906..1639925) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 37.2 kDa protein Rv2165c or MT2223 or MTCY270.03 SW:YL65_MYCTU (O06212) (344 aa) fasta scores: E(): 4.8e-62, 56.34% id in 323 aa; S-adenosyl-methyltransferase MraW 1639925 mraW 2650795 mraW Corynebacterium diphtheriae NCTC 13129 S-adenosyl-methyltransferase MraW NP_939948.1 1638906 R 257309 CDS NP_939949.1 38234182 2650796 complement(1640108..1640539) 1 NC_002935.2 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 1640539 2650796 DIP1607 Corynebacterium diphtheriae NCTC 13129 cell division protein MraZ NP_939949.1 1640108 R 257309 CDS NP_939950.1 38234183 2650797 complement(1641087..1641491) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 14.6 kDa protein Rv2169c or MTV021.02c TR:O53503 (EMBL:AL021957) (134 aa) fasta scores: E(): 8.5e-11, 38.93% id in 131 aa; hypothetical protein 1641491 2650797 DIP1608 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939950.1 1641087 R 257309 CDS NP_939951.1 38234184 2650798 complement(1641600..1642154) 1 NC_002935.2 hypothetical protein 1642154 2650798 DIP1609 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939951.1 1641600 R 257309 CDS NP_939952.1 38234185 2650799 1642218..1642796 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 22.9 kDa protein Rv2170 or MTV021.03 TR:O53504 (EMBL:AL021957) (206 aa) fasta scores: E(): 3.4e-16, 35.14% id in 202 aa; hypothetical protein 1642796 2650799 DIP1610 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939952.1 1642218 D 257309 CDS NP_939953.1 38234186 2650800 complement(1642793..1643776) 1 NC_002935.2 Similar to Streptomyces lividans 5,10-methylenetetrahydrofolate reductase MetF SW:METF_STRLI (O54235) (307 aa) fasta scores: E(): 4.1e-41, 41.58% id in 303 aa, and to Escherichia coli 5,10-methylenetetrahydrofolate reductase MetF or B3941 SW:METF_ECOLI (P00394) (296 aa) fasta scores: E(): 9.2e-15, 33.65% id in 309 aa; methylenetetrahydrofolate reductase 1643776 2650800 DIP1611 Corynebacterium diphtheriae NCTC 13129 methylenetetrahydrofolate reductase NP_939953.1 1642793 R 257309 CDS NP_939954.1 38234187 2650801 1643980..1645104 1 NC_002935.2 Similar to Mycobacterium aurum geranylgeranyl pyrophosphate synthase GgpP TR:Q9K567 (EMBL:AJ133724) (371 aa) fasta scores: E(): 1.5e-36, 39.09% id in 353 aa, and to Sulfolobus acidocaldarius geranylgeranyl pyrophosphate synthetase Gds SW:GGPP_SULAC (P39464) (330 aa) fasta scores: E(): 3.1e-11, 28.49% id in 358 aa; geranylgeranyl pyrophosphate synthase 1645104 2650801 DIP1612 Corynebacterium diphtheriae NCTC 13129 geranylgeranyl pyrophosphate synthase NP_939954.1 1643980 D 257309 CDS NP_939955.1 38234188 2650802 1645126..1646613 1 NC_002935.2 Similar to Mycobacterium tuberculosis membrane protein Rv2174 or MTV021.07 TR:O53508 (EMBL:AL021957) (516 aa) fasta scores: E(): 2.2e-56, 34.69% id in 464 aa; hypothetical protein 1646613 2650802 DIP1613 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939955.1 1645126 D 257309 CDS NP_939956.1 38234189 2650803 complement(1646614..1646982) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 15.7 kDa protein Rv2175c or MTV021.08c TR:O53509 (EMBL:AL021957) (146 aa) fasta scores: E(): 7.8e-08, 40.45% id in 131 aa; hypothetical protein 1646982 2650803 DIP1614 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939956.1 1646614 R 257309 CDS NP_939957.1 38234190 2650804 1647084..1649276 1 NC_002935.2 Similar to Streptomyces coelicolor eukaryotic-type protein kinase PkaF TR:Q9ZNB3 (EMBL:AB019394) (629 aa) fasta scores: E(): 8.2e-37, 36.22% id in 646 aa; serine/threonine protein kinase 1649276 2650804 DIP1615 Corynebacterium diphtheriae NCTC 13129 serine/threonine protein kinase NP_939957.1 1647084 D 257309 CDS NP_939958.1 38234191 2650805 complement(1649344..1650732) 1 NC_002935.2 Similar to Streptomyces coelicolor phospho-2-dehydro-3-deoxyheptonate aldolase AroH or SC6E10.09c SW:AROF_STRCO (P80574) (449 aa) fasta scores: E(): 2.4e-92, 55.6% id in 437 aa, and to Mycobacterium tuberculosis CDC1551 phospho-2-dehydro-3-deoxyheptonate aldolase, MT2234 TR:AAK46519 (EMBL:AE007070) (462 aa) fasta scores: E(): 2.9e-129, 67.53% id in 462 aa; phospho-2-dehydro-3-deoxyheptonate aldolase 1650732 aroH 2650805 aroH Corynebacterium diphtheriae NCTC 13129 phospho-2-dehydro-3-deoxyheptonate aldolase NP_939958.1 1649344 R 257309 CDS NP_939959.1 38234192 2648663 complement(1650846..1651355) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT2234.1 TR:AAK46520 (EMBL:AE007070) (168 aa) fasta scores: E(): 1.1e-35, 59.35% id in 155 aa; hypothetical protein 1651355 2648663 DIP1617 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939959.1 1650846 R 257309 CDS NP_939960.1 38234193 2648664 complement(1651422..1652147) 1 NC_002935.2 Similar to Corynebacterium glutamicum hypothetical 27.1 kDa protein TR:Q9KKE6 (EMBL:AF096280) (245 aa) fasta scores: E(): 1.9e-67, 67.91% id in 240 aa, and to Streptomyces coelicolor acyltransferase 2SCG1.03 TR:Q9FCD9 (EMBL:AL391014) (240 aa) fasta scores: E(): 1.3e-37, 46.63% id in 238 aa; acyltransferase 1652147 2648664 DIP1618 Corynebacterium diphtheriae NCTC 13129 acyltransferase NP_939960.1 1651422 R 257309 CDS NP_939961.1 38234194 2648665 complement(1652199..1653152) 1 NC_002935.2 Similar to Corynebacterium glutamicum glucose kinase Glk TR:Q9KKE7 (EMBL:AF096280) (323 aa) fasta scores: E(): 2.5e-79, 62.38% id in 319 aa, and to Streptomyces coelicolor glucokinase Glk or SC6E10.20c SW:GLK_STRCO (P40184) (317 aa) fasta scores: E(): 5.7e-45, 40% id in 310 aa; glucose kinase 1653152 glk 2648665 glk Corynebacterium diphtheriae NCTC 13129 glucose kinase NP_939961.1 1652199 R 257309 CDS NP_939962.1 38234195 2648666 complement(1653283..1654416) 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical 41.1 kDa protein ML0886 or MLCB268.31c TR:O69579 (EMBL:AL022602) (384 aa) fasta scores: E(): 1.9e-64, 51.18% id in 381 aa, and to Mycobacterium tuberculosis CDC1551 glycosyl transferase MT2243 TR:AAK46529 (EMBL:AE007070) (385 aa) fasta scores: E(): 8e-64, 50.65% id in 381 aa; hypothetical protein 1654416 2648666 DIP1620 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939962.1 1653283 R 257309 CDS NP_939963.1 38234196 2648667 complement(1654437..1655450) 1 NC_002935.2 Similar to Mycobacterium leprae secreted protein ML0885 or MLCB268.32c TR:O69580 (EMBL:AL022602) (374 aa) fasta scores: E(): 1.7e-22, 36.2% id in 348 aa; hypothetical protein 1655450 2648667 DIP1621 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939963.1 1654437 R 257309 CDS NP_939964.1 38234197 2648668 complement(1655620..1656384) 1 NC_002935.2 Similar to the C-terminal region of Mycobacterium leprae secreted protein ML0885 or MLCB268.32c TR:O69580 (EMBL:AL022602) (374 aa) fasta scores: E(): 6e-19, 40.35% id in 223 aa; hypothetical protein 1656384 2648668 DIP1622 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939964.1 1655620 R 257309 CDS NP_939965.1 38234198 2648669 complement(1656493..1656735) 1 NC_002935.2 hypothetical protein 1656735 2648669 DIP1623 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939965.1 1656493 R 257309 CDS NP_939966.1 38234199 2648670 complement(1657014..1658636) 1 NC_002935.2 Similar to Corynebacterium glutamicum cytochrome B of BC1 complex CytB or QcrB TR:Q9AEL5 (EMBL:AJ306418) (539 aa) fasta scores: E(): 1.1e-173, 81.08% id in 534 aa, and to Streptomyces lividans ubiquinol-cytochrome C reductase cytochrome B subunit QcrB SW:QCRB_STRLI (Q9ZFB6) (549 aa) fasta scores: E(): 2.2e-88, 47.32% id in 486 aa; ubiquinol-cytochrome C reductase cytochrome B subunit 1658636 qcrB 2648670 qcrB Corynebacterium diphtheriae NCTC 13129 ubiquinol-cytochrome C reductase cytochrome B subunit NP_939966.1 1657014 R 257309 CDS NP_939967.1 38234200 2648671 complement(1658633..1659853) 1 NC_002935.2 Similar to Corynebacterium glutamicum iron-sulfur protein QcrA TR:Q9F482 (EMBL:AB047851) (392 aa) fasta scores: E(): 5.7e-128, 76.78% id in 392 aa, and to Mycobacterium tuberculosis ubiquinol-cytochrome C reductase iron-sulfur subunit QcrA or Rv2195 or MT2251 or MTCY190.06 SW:QCRA_MYCTU (Q10387) (429 aa) fasta scores: E(): 4.9e-37, 51.13% id in 395 aa; ubiquinol-cytochrome C reductase iron-sulfur protein 1659853 qcrA 2648671 qcrA Corynebacterium diphtheriae NCTC 13129 ubiquinol-cytochrome C reductase iron-sulfur protein NP_939967.1 1658633 R 257309 CDS NP_939968.1 38234201 2648672 complement(1659850..1660695) 1 NC_002935.2 Similar to Corynebacterium glutamicum cytochrome CC1 subunit QcrC TR:Q9F483 (EMBL:AB047851) (283 aa) fasta scores: E(): 1.9e-86, 81.36% id in 279 aa, and to Mycobacterium tuberculosis ubiquinol-cytochrome C reductase cytochrome C subunit QcrC or Rv2194 or MT2250 or MTCY190.05 SW:QCRC_MYCTU (Q10386) (280 aa) fasta scores: E(): 3.5e-29, 60.43% id in 278 aa; ubiquinol-cytochrome C reductase cytochrome C subunit 1660695 qcrC 2648672 qcrC Corynebacterium diphtheriae NCTC 13129 ubiquinol-cytochrome C reductase cytochrome C subunit NP_939968.1 1659850 R 257309 CDS NP_939969.1 38234202 2648673 complement(1660829..1661446) 1 NC_002935.2 Similar to Corynebacterium glutamicum cytochrome AA3 oxidase subunit III CtaE TR:Q9AEL8 (EMBL:AJ306418) (205 aa) fasta scores: E(): 9.9e-67, 81.95% id in 205 aa, and to Mycobacterium tuberculosis probable cytochrome C oxidase polypeptide III CtaE or Rv2193 or MT2249 or MTCY190.04 SW:COX3_MYCTU (Q10385) (203 aa) fasta scores: E(): 3.6e-47, 60% id in 205 aa; cytochrome C oxidase subunit III 1661446 ctaE 2648673 ctaE Corynebacterium diphtheriae NCTC 13129 cytochrome C oxidase subunit III NP_939969.1 1660829 R 257309 CDS NP_939970.1 38234203 2648674 complement(1661984..1662415) 1 NC_002935.2 Similar to Mycobacterium leprae membrane protein ML0876 TR:Q9CCF0 (EMBL:AL583920) (139 aa) fasta scores: E(): 6.6e-13, 34.93% id in 146 aa; hypothetical protein 1662415 2648674 DIP1628 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939970.1 1661984 R 257309 CDS NP_939971.1 38234204 2648675 complement(1662439..1663527) 1 NC_002935.2 Similar to Mycobacterium tuberculosis probable cytochrome C oxidase polypeptide II precursor CtaC or Rv2200c or MT2256 or MTCY190.11c SW:COX2_MYCTU (Q10375) (363 aa) fasta scores: E(): 3.5e-59, 47.55% id in 347 aa, and to Bacillus subtilis cytochrome C oxidase polypeptide II precursor CtaC SW:COX2_BACSU (P24011) (356 aa) fasta scores: E(): 2.1e-07, 24.61% id in 321 aa; cytochrome C oxidase 1663527 2648675 DIP1629 Corynebacterium diphtheriae NCTC 13129 cytochrome C oxidase NP_939971.1 1662439 R 257309 CDS NP_939972.1 38234205 2648676 1663954..1665876 1 NC_002935.2 Highly similar to Corynebacterium glutamicum LtsA TR:Q9LCB7 (EMBL:AB029550) (640 aa) fasta scores: E(): 0, 83.9% id in 640 aa, and to Bacillus subtilis asparagine synthetase [glutamine-hydrolyzing] 1 AsnB or Asn SW:ASNB_BACSU (P54420) (632 aa) fasta scores: E(): 2.8e-111, 49.76% id in 631 aa; asparagine synthetase 1665876 asnB 2648676 asnB Corynebacterium diphtheriae NCTC 13129 asparagine synthetase NP_939972.1 1663954 D 257309 CDS NP_939973.1 38234206 2648677 complement(1665967..1666311) 1 NC_002935.2 Similar to Corynebacterium glutamicum ORF1 TR:Q9LCB6 (EMBL:AB029550) (114 aa) fasta scores: E(): 3.2e-36, 84.21% id in 114 aa, and to Escherichia coli hypothetical protein YadR or B0156 or Z0167 or ECS0160 SW:YADR_ECOLI (P37026) (114 aa) fasta scores: E(): 7.2e-15, 44.66% id in 103 aa; hypothetical protein 1666311 2648677 DIP1631 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939973.1 1665967 R 257309 CDS NP_939974.1 38234207 2648678 1666530..1667204 1 NC_002935.2 Similar to Streptomyces coelicolor integral membrane protein SC5F7.32 TR:Q9S2R7 (EMBL:AL096872) (251 aa) fasta scores: E(): 4.8e-10, 30.45% id in 220 aa; hypothetical protein 1667204 2648678 DIP1632 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939974.1 1666530 D 257309 CDS NP_939975.1 38234208 2648679 1667205..1667753 1 NC_002935.2 Similar to Mycobacterium tuberculosis cobinamide kinase CobU or Rv0254c or MTV034.20 TR:O53676 (EMBL:AL021929) (174 aa) fasta scores: E(): 6.7e-21, 44.38% id in 178 aa, and to Escherichia coli, and bifunctional cobalamin biosynthesis protein CobU [includes: cobinamide kinase; cobinamide phosphate guanylyltransferase] or B1993 or Z3153 or ECS2788 SW:COBU_ECOLI (P46886) (181 aa) fasta scores: E(): 1.8e-13, 35.48% id in 186 aa; cobinamide kinase 1667753 cobU 2648679 cobU Corynebacterium diphtheriae NCTC 13129 cobinamide kinase NP_939975.1 1667205 D 257309 CDS NP_939976.1 38234209 2648680 1667803..1668873 1 NC_002935.2 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 1668873 cobT 2648680 cobT Corynebacterium diphtheriae NCTC 13129 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase NP_939976.1 1667803 D 257309 CDS NP_939977.1 38234210 2648681 1668881..1669705 1 NC_002935.2 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 1669705 cobS 2648681 cobS Corynebacterium diphtheriae NCTC 13129 cobalamin synthase NP_939977.1 1668881 D 257309 CDS NP_939978.1 38234211 2648682 complement(1669782..1670897) 1 NC_002935.2 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 1670897 ilvE 2648682 ilvE Corynebacterium diphtheriae NCTC 13129 branched-chain amino acid aminotransferase NP_939978.1 1669782 R 257309 CDS NP_939979.1 38234212 2648683 1670998..1672500 1 NC_002935.2 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 1672500 2648683 DIP1637 Corynebacterium diphtheriae NCTC 13129 leucyl aminopeptidase NP_939979.1 1670998 D 257309 CDS NP_939980.1 38234213 2648684 complement(1672564..1672980) 1 NC_002935.2 Similar to Saccharopolyspora erythraea ORF1, 5' end; NADH-ferredoxin oxidoreductase (fragment) TR:Q54100 (EMBL:L38646) (93 aa) fasta scores: E(): 1.9e-08, 42.16% id in 83 aa; oxidoreductase 1672980 2648684 DIP1638 Corynebacterium diphtheriae NCTC 13129 oxidoreductase NP_939980.1 1672564 R 257309 CDS NP_939981.1 38234214 2648685 1673085..1675034 1 NC_002935.2 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 1675034 aceF 2648685 aceF Corynebacterium diphtheriae NCTC 13129 dihydrolipoamide acetyltransferase NP_939981.1 1673085 D 257309 CDS NP_939982.1 38234215 2648686 1675151..1675903 1 NC_002935.2 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 1675903 lipB 2648686 lipB Corynebacterium diphtheriae NCTC 13129 lipoate-protein ligase B NP_939982.1 1675151 D 257309 CDS NP_939983.1 38234216 2648687 1675956..1677044 1 NC_002935.2 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 1677044 lipA 2648687 lipA Corynebacterium diphtheriae NCTC 13129 lipoyl synthase NP_939983.1 1675956 D 257309 CDS NP_939984.1 38234217 2648688 1677107..1677880 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 26.9 kDa protein Rvv2219 precursor or MT2276 or MTCY190.30 SW:YM19_MYCTU (Q10405) (250 aa) fasta scores: E(): 2.4e-36, 42.8% id in 250 aa; hypothetical protein 1677880 2648688 DIP1642 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939984.1 1677107 D 257309 CDS NP_939985.1 38234218 2648689 complement(1677927..1678433) 1 NC_002935.2 Similar to Streptomyces coelicolor integral membrane protein SC3H12.05c TR:Q9S2N9 (EMBL:AL355740) (155 aa) fasta scores: E(): 6.1e-16, 43.04% id in 151 aa; hypothetical protein 1678433 2648689 DIP1643 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939985.1 1677927 R 257309 CDS NP_939986.1 38234219 2648690 1678597..1680033 1 NC_002935.2 Similar to Corynebacterium glutamicum glutamine synthetase I GlnA TR:O32354 (EMBL:Y13221) (477 aa) fasta scores: E(): 6.8e-157, 79.49% id in 478 aa, and to Streptomyces coelicolor glutamine synthetase GlnA or SC3H12.06 SW:GLNA_STRCO (P15106) (469 aa) fasta scores: E(): 3.6e-128, 66.31% id in 475 aa. Also similar to DIP1671, glnA2 (456 aa); fasta scores: E(): 5e-31, 32.353% identity in 476 aa overlap; glutamine synthetase 1680033 glnA1 2648690 glnA1 Corynebacterium diphtheriae NCTC 13129 glutamine synthetase NP_939986.1 1678597 D 257309 CDS NP_939987.1 38234220 2648691 1680222..1680482 1 NC_002935.2 hypothetical protein 1680482 2648691 DIP1645 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939987.1 1680222 D 257309 CDS NP_939988.1 38234221 2648692 1680647..1681126 1 NC_002935.2 Similar to Caulobacter crescentus hypothetical protein CC3515 TR:Q9A2P1 (EMBL:AE006010) (188 aa) fasta scores: E(): 7.7e-06, 31.200% id in 125 aa; hypothetical protein 1681126 2648692 DIP1646 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939988.1 1680647 D 257309 CDS NP_939989.1 38234222 2648693 1681123..1681500 1 NC_002935.2 hypothetical protein 1681500 2648693 DIP1647 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939989.1 1681123 D 257309 CDS NP_939990.1 38234223 2648695 complement(1683094..1683417) 1 NC_002935.2 hypothetical protein 1683417 2648695 DIP1650 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939990.1 1683094 R 257309 CDS NP_939991.1 38234224 2648696 complement(1683728..1684663) 1 NC_002935.2 Similar to Neisseria meningitidis hypothetical protein NMB0234 TR:Q9K1C8 (EMBL:AE002381) (179 aa) fasta scores: E(): 0.00039, 28.313% id in 166 aa; hypothetical protein 1684663 2648696 DIP1651 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939991.1 1683728 R 257309 CDS NP_939992.1 38234225 2648697 complement(1684673..1688437) 1 NC_002935.2 Similar to Streptomyces coelicolor secreted protein SC2G5.19 TR:Q9Z5A4 (EMBL:AL035478) (1156 aa) fasta scores: E(): 7.4e-51, 32.373% id in 1041 aa; hypothetical protein 1688437 2648697 DIP1652 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939992.1 1684673 R 257309 CDS NP_939993.1 38234226 2648698 complement(1688451..1689344) 1 NC_002935.2 hypothetical protein 1689344 2648698 DIP1653 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939993.1 1688451 R 257309 CDS NP_939994.1 38234227 2648699 complement(1689384..1690178) 1 NC_002935.2 Weak similarity to C-terminus of Corynebacterium glutamicum PS1 protein precursor Csp1 SW:CSP1_CORGL (Q01377) (657 aa) fasta scores: E(): 4.3e-06, 26.943% id in 193 aa; hypothetical protein 1690178 2648699 DIP1654 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939994.1 1689384 R 257309 CDS NP_939995.1 38234228 2648700 complement(1690224..1690688) 1 NC_002935.2 Weak similarity to C-terminus of Corynebacterium glutamicum PS1 protein precursor Csp1 SW:CSP1_CORGL (Q01377) (657 aa) fasta scores: E(): 1.7e-07, 40.196% id in 102 aa; hypothetical protein 1690688 2648700 DIP1655 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939995.1 1690224 R 257309 CDS NP_939996.1 38234229 2648701 1691457..1693697 1 NC_002935.2 Similar to Helicobacter pylori hypothetical 88.8 kDa protein HP1142 TR:O25761 (EMBL:AE000620) (759 aa) fasta scores: E(): 1.7e-53, 29.896% id in 766 aa, and to Staphylococcus aureus hypothetical 50.1 kDa protein TR:BAB47139 (EMBL:AB047239) (422 aa) fasta scores: E(): 1.4e-05, 24.340% id in 341 aa; hypothetical protein 1693697 2648701 DIP1656 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939996.1 1691457 D 257309 CDS NP_939997.1 38234230 2648702 1693807..1694001 1 NC_002935.2 hypothetical protein 1694001 2648702 DIP1657 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939997.1 1693807 D 257309 CDS NP_939998.1 38234231 2648703 complement(1694157..1695038) 1 NC_002935.2 hypothetical protein 1695038 2648703 DIP1658 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939998.1 1694157 R 257309 CDS NP_939999.1 38234232 2648704 complement(1695397..1696269) 1 NC_002935.2 hypothetical protein 1696269 2648704 DIP1659 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_939999.1 1695397 R 257309 CDS NP_940000.1 38234233 2648705 complement(1696679..1696888) 1 NC_002935.2 Similar to Agrobacterium tumefaciens AGR_C_1429p AGR_C_1429 TR:AAK86591 (EMBL:AE008011) (63 aa) fasta scores: E(): 0.0028, 45.283% id in 53 aa, and to Streptococcus pyogenes hypothetical protein SPY1261 TR:Q99ZE6 (EMBL:AE006565) (66 aa) fasta scores: E(): 0.0045, 37.931% id in 58 aa, and to Rhizobium meliloti hypothetical 10.1 kDa protein SMA2071 TR:AAK65789 (EMBL:AE007299) (96 aa) fasta scores: E(): 0.0053, 46.154% id in 52 aa, and to Staphylococcus aureus subspaureus N315. sigmaB-controlled gene product CsbD or SA1452 TR:Q99TM4 (EMBL:AP003134) (60 aa) fasta scores: E(): 0.0065, 38.983% id in 59 aa; hypothetical protein 1696888 2648705 DIP1660 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940000.1 1696679 R 257309 CDS NP_940001.1 38234234 2648706 complement(1697001..1698353) 1 NC_002935.2 Similar to Neisseria meningitidis integral membrane protein NMA0370 TR:Q9JWH5 (EMBL:AL162753) (462 aa) fasta scores: E(): 8.6e-89, 59.488% id in 469 aa, and to Pasteurella multocida hypothetical protein PM0989 TR:Q9CM54 (EMBL:AE006138) (452 aa) fasta scores: E(): 3.3e-82, 52.402% id in 458 aa; hypothetical protein 1698353 2648706 DIP1661 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940001.1 1697001 R 257309 CDS NP_940002.1 38234235 2648707 1698485..1699168 1 NC_002935.2 Similar to Streptomyces coelicolor GntR-family transcriptional regulator SCGD3.11c TR:Q9XA67 (EMBL:AL096822) (216 aa) fasta scores: E(): 3e-22, 35.122% id in 205 aa, and to Rhizobium meliloti GntR-family transcriptional regulator SMA0065 TR:AAK64690 (EMBL:AE007198) (230 aa) fasta scores: E(): 6.1e-11, 29.293% id in 198 aa; GntR family transcriptional regulator 1699168 2648707 DIP1662 Corynebacterium diphtheriae NCTC 13129 GntR family transcriptional regulator NP_940002.1 1698485 D 257309 CDS NP_940003.1 38234236 2648708 1699190..1700449 1 NC_002935.2 Similar to Streptomyces viridifaciens valanimycin resistant protein VlmF TR:Q9LA76 (EMBL:AF148322) (402 aa) fasta scores: E(): 2.2e-10, 28.186% id in 408 aa, and to Pseudomonas aeruginosa probable MFS transporter PA5282 TR:Q9HTS2 (EMBL:AE004940) (389 aa) fasta scores: E(): 2.7e-06, 27.877% id in 391 aa; MFS family transporter 1700449 2648708 DIP1663 Corynebacterium diphtheriae NCTC 13129 MFS family transporter NP_940003.1 1699190 D 257309 CDS NP_940004.1 38234237 2648709 complement(1700446..1700982) 1 NC_002935.2 Similar to Streptomyces coelicolor Mut-like protein 2SCG2.26c TR:Q9EX27 (EMBL:AL445963) (159 aa) fasta scores: E(): 1.3e-15, 46.7% id in 167 aa; hypothetical protein 1700982 2648709 DIP1664 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940004.1 1700446 R 257309 CDS NP_940005.1 38234238 2648710 complement(1701013..1701159) 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 1701159 2648710 DIP1665 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940005.1 1701013 R 257309 CDS NP_940006.1 38234239 2648711 complement(1701262..1702710) 1 NC_002935.2 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1702710 thrC 2648711 thrC Corynebacterium diphtheriae NCTC 13129 threonine synthase NP_940006.1 1701262 R 257309 CDS NP_940007.1 38234240 2648712 1702727..1703674 1 NC_002935.2 hypothetical protein 1703674 2648712 DIP1667 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940007.1 1702727 D 257309 CDS NP_940008.1 38234241 2648713 complement(1703671..1703940) 1 NC_002935.2 hypothetical protein 1703940 2648713 DIP1668 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940008.1 1703671 R 257309 CDS NP_940009.1 38234242 2648714 complement(1704009..1704656) 1 NC_002935.2 Almost identical to previously sequenced as Corynebacterium diphtheriae heme oxygenase HmuO SW:HMUO_CORDI (P71119) (215 aa) fasta scores: E(): 3.8e-78, 97.67% id in 215 aa; heme oxygenase 1704656 hmuO 2648714 hmuO Corynebacterium diphtheriae NCTC 13129 heme oxygenase NP_940009.1 1704009 R 257309 CDS NP_940010.1 38234243 2648715 complement(1704796..1707960) 1 NC_002935.2 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 1707960 glnE 2648715 glnE Corynebacterium diphtheriae NCTC 13129 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase NP_940010.1 1704796 R 257309 CDS NP_940011.1 38234244 2648716 complement(1708011..1709351) 1 NC_002935.2 Similar to Corynebacterium glutamicum glutamine synthetase II GlnA2 TR:Q9AEL4 (EMBL:AJ310086) (427 aa) fasta scores: E(): 4.4e-141, 78.4% id in 426 aa, and to Bacillus subtilis glutamine synthetase GlnA SW:GLNA_BACSU (P12425) (443 aa) fasta scores: E(): 1.3e-69, 44.62% id in 437 aa. Note: Also similar to DIP1644 (478 aa); fasta scores: E(): 9.9e-32; 32.353% identity in 476 aa overlap; glutamine synthetase 1709351 glnA2 2648716 glnA2 Corynebacterium diphtheriae NCTC 13129 glutamine synthetase NP_940011.1 1708011 R 257309 CDS NP_940012.1 38234245 2648717 1709494..1711068 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 56.3 kDa protein Rv2226 or MT2285 or MTCY427.07 SW:YM26_MYCTU (Q10510) (513 aa) fasta scores: E(): 2.6e-38, 34.64% id in 534 aa; hypothetical protein 1711068 2648717 DIP1672 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940012.1 1709494 D 257309 CDS NP_940013.1 38234246 2648718 complement(1711078..1711269) 1 NC_002935.2 Low similarity to Streptomyces coelicolor hypothetical 10.4 kDa protein SCC75A.11c TR:Q9RKR3 (EMBL:AL133220) (92 aa) fasta scores: E(): 0.00053, 39.28% id in 56 aa; hypothetical protein 1711269 2648718 DIP1673 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940013.1 1711078 R 257309 CDS NP_940014.1 38234247 2648719 1711326..1712669 1 NC_002935.2 Very low similarity to Homo sapiens galactokinase GalK1 or GalK SW:GAL1_HUMAN (P51570) blast scores: E(): 3e-05, score: 51 24% id; hypothetical protein 1712669 2648719 DIP1674 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940014.1 1711326 D 257309 CDS NP_940015.1 38234248 2648722 complement(1714046..1714753) 1 NC_002935.2 hypothetical protein 1714753 2648722 DIP1677 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940015.1 1714046 R 257309 CDS NP_940016.1 38234249 2648723 complement(1715369..1716502) 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical 39.8 kDa protein ML1637 or MLCB1243.38 TR:O69483 (EMBL:AL023635) (371 aa) fasta scores: E(): 1.8e-73, 54.61% id in 379 aa; bifunctional RNase H/acid phosphatase 1716502 2648723 DIP1678 Corynebacterium diphtheriae NCTC 13129 bifunctional RNase H/acid phosphatase NP_940016.1 1715369 R 257309 CDS NP_940017.1 38234250 2648724 complement(1716502..1717218) 1 NC_002935.2 Low similarity to Mycobacterium tuberculosis hypothetical 26.9 kDa protein Rv2229c or MT2288 or MTCY427.10c SW:YM29_MYCTU (Q10513) (245 aa) fasta scores: E(): 1.9e-06, 23.75% id in 240 aa; hypothetical protein 1717218 2648724 DIP1679 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940017.1 1716502 R 257309 CDS NP_940018.1 38234251 2648725 complement(1717298..1718434) 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical 40.3 kDa protein ML1639 or MLCB1243.36 TR:O69481 (EMBL:AL023635) (385 aa) fasta scores: E(): 4.3e-74, 54.27% id in 374 aa; hypothetical protein 1718434 2648725 DIP1680 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940018.1 1717298 R 257309 CDS NP_940019.1 38234252 2648726 complement(1718437..1719471) 1 NC_002935.2 Similar to Mycobacterium tuberculosis aminotransferase Rv2231c or MT2290 or MTCY427.12c SW:YM31_MYCTU (Q10503) (364 aa) fasta scores: E(): 1.7e-50, 45.67% id in 335 aa and to Salmonella typhimurium CobD TR:P97084 (EMBL:U90625) (364 aa) fasta scores: E(): 3.6e-18, 27.76% id in 335 aa; hypothetical protein 1719471 2648726 DIP1681 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940019.1 1718437 R 257309 CDS NP_940020.1 38234253 2650272 1719502..1720146 1 NC_002935.2 Similar to Alcaligenes eutrophus phosphoglycolate phosphatase, chromosomal CbbZC SW:GPHC_ALCEU (P40852) (231 aa) fasta scores: E(): 3.5e-08, 30.85% id in 188 aa; phosphoglycolate phosphatase 1720146 2650272 DIP1682 Corynebacterium diphtheriae NCTC 13129 phosphoglycolate phosphatase NP_940020.1 1719502 D 257309 CDS NP_940021.1 38234254 2650273 1720169..1720630 1 NC_002935.2 Similar to Streptomyces coelicolor low molecular weight protein-tyrosine-phosphatase PtpA or SCQ11.04c SW:PTPA_STRCO (P53433) (164 aa) fasta scores: E(): 1.3e-21, 47.43% id in 156 aa, and to Bos taurus low molecular weight phosphotyrosine protein phosphatase Acp1 SW:PPAC_BOVIN (P11064) (157 aa) fasta scores: E(): 9.2e-12, 35.55% id in 135 aa; low molecular weight protein-tyrosine-phosphatase 1720630 2650273 DIP1683 Corynebacterium diphtheriae NCTC 13129 low molecular weight protein-tyrosine-phosphatase NP_940021.1 1720169 D 257309 CDS NP_940022.1 38234255 2650274 1720659..1721492 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 29.8 kDa protein Rv2235 precursor or MT2294 or MTCY427.16 SW:YM35_MYCTU (Q10517) (271 aa) fasta scores: E(): 1.4e-34, 38.54% id in 275 aa; hypothetical protein 1721492 2650274 DIP1684 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940022.1 1720659 D 257309 CDS NP_940023.1 38234256 2650275 complement(1721486..1722388) 1 NC_002935.2 Similar to Streptomyces coelicolor cobalamin biosynthesis protein CobD TR:Q9RJ21 (EMBL:AL132644) (327 aa) fasta scores: E(): 3.7e-39, 44.8% id in 308 aa, and to Rhodobacter capsulatus cobalamin biosynthesis protein CobD or BluD SW:COBD_RHOCA (Q52683) (314 aa) fasta scores: E(): 2.4e-23, 33.44% id in 311 aa; cobalamin biosynthesis protein 1722388 2650275 DIP1685 Corynebacterium diphtheriae NCTC 13129 cobalamin biosynthesis protein NP_940023.1 1721486 R 257309 CDS NP_940024.1 38234257 2650277 complement(1722618..1723055) 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical 15.2 kDa protein ML1649 or MLCB1243.26 TR:O69479 (EMBL:AL023635) (140 aa) fasta scores: E(): 4.1e-24, 56.55% id in 122 aa; hypothetical protein 1723055 2650277 DIP1686 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940024.1 1722618 R 257309 CDS NP_940025.1 38234258 2650278 1723276..1726011 1 NC_002935.2 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 1726011 aceE 2650278 aceE Corynebacterium diphtheriae NCTC 13129 pyruvate dehydrogenase subunit E1 NP_940025.1 1723276 D 257309 CDS NP_940026.1 38234259 2650279 1726207..1726770 1 NC_002935.2 Similar to Streptomyces coelicolor secreted protein SCJ1.02c TR:Q9RJ12 (EMBL:AL109962) (195 aa) fasta scores: E(): 4.6e-25, 44.69% id in 179 aa; hypothetical protein 1726770 2650279 DIP1688 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940026.1 1726207 D 257309 CDS NP_940027.1 38234260 2650280 complement(1726799..1729045) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 lipopolysaccharide biosynthesis protein WbpC, MT1616 TR:AAK45883 (EMBL:AE007027) (729 aa) fasta scores: E(): 8.2e-42, 34.25% id in 762 aa; hypothetical protein 1729045 2650280 DIP1689 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940027.1 1726799 R 257309 CDS NP_940028.1 38234261 2650281 1729135..1730457 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical 50.2 kDa protein ML1338 or MLC1351.25 TR:O05686 (EMBL:Z95117) (440 aa) fasta scores: E(): 1.8e-11, 29.77% id in 393 aa; hypothetical protein 1730457 2650281 DIP1690 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940028.1 1729135 D 257309 CDS NP_940029.1 38234262 2650282 complement(1730402..1731367) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 hydrolase, alpha/beta hydrolase fold family MT3260 TR:AAK47599 (EMBL:AE007139) (323 aa) fasta scores: E(): 3.5e-10, 29.32% id in 324 aa; alpha/beta hydrolase 1731367 2650282 DIP1691 Corynebacterium diphtheriae NCTC 13129 alpha/beta hydrolase NP_940029.1 1730402 R 257309 CDS NP_940030.1 38234263 2650283 1731464..1731721 1 NC_002935.2 Similar to Thermotoga maritima acyl carrier protein TM0662 TR:Q9WZD0 (EMBL:AE001739) (81 aa) fasta scores: E(): 0.0012, 32.05% id in 78 aa, and to Bacillus halodurans acyl carrier protein AcpA or BH2490 SW:ACP_BACHD (Q9KA04) (77 aa) fasta scores: E(): 0.0062, 32.87% id in 73 aa; acyl carrier protein 1731721 2650283 DIP1692 Corynebacterium diphtheriae NCTC 13129 acyl carrier protein NP_940030.1 1731464 D 257309 CDS NP_940031.1 38234264 2650284 1731758..1732567 1 NC_002935.2 Similar to Streptomyces coelicolor conserved hypothetical protein SCE20.17c TR:Q9RDA8 (EMBL:AL136058) (259 aa) fasta scores: E(): 4.9e-62, 65.86% id in 249 aa, and to Escherichia coli NagD protein or B0675 or Z0822 or ECS0705 SW:NAGD_ECOLI (P15302) (250 aa) fasta scores: E(): 1e-37, 43.02% id in 251 aa; N-acetylglucosamine-like protein 1732567 2650284 DIP1693 Corynebacterium diphtheriae NCTC 13129 N-acetylglucosamine-like protein NP_940031.1 1731758 D 257309 CDS NP_940032.1 38234265 2650285 complement(1732564..1732932) 1 NC_002935.2 hypothetical protein 1732932 2650285 DIP1694 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940032.1 1732564 R 257309 CDS NP_940033.1 38234266 2650286 complement(1733031..1733852) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 28.7 kDa protein SC4A7.08 TR:Q9RDQ4 (EMBL:AL133423) (273 aa) fasta scores: E(): 1.3e-49, 50.19% id in 259 aa; hypothetical protein 1733852 2650286 DIP1695 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940033.1 1733031 R 257309 CDS NP_940034.1 38234267 2650287 complement(1733849..1734676) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical protein SC2A11.15 SW:YU26_STRCO (O86576) (219 aa) fasta scores: E(): 8.3e-14, 32.68% id in 205 aa; hypothetical protein 1734676 2650287 DIP1696 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940034.1 1733849 R 257309 CDS NP_940035.1 38234268 2650290 1735145..1735387 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 hypothetical 10.3 kDa protein MT2407 TR:AAK46700 (EMBL:AE007081) (97 aa) fasta scores: E(): 2.2e-05, 46.42% id in 56 aa; hypothetical protein 1735387 2650290 DIP1697 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940035.1 1735145 D 257309 CDS NP_940036.1 38234269 2650291 1735479..1736036 1 NC_002935.2 Similar to Corynebacterium glutamicum thiamine biosynthesis protein X ThiX SW:THIX_CORGL (P42461) (133 aa) fasta scores: E(): 2.5e-12, 38.09% id in 126 aa; thiamine biosynthesis-like protein 1736036 2650291 DIP1698 Corynebacterium diphtheriae NCTC 13129 thiamine biosynthesis-like protein NP_940036.1 1735479 D 257309 CDS NP_940037.1 38234270 2650292 complement(1736085..1737983) 1 NC_002935.2 synthesizes RNA primers at the replication forks; DNA primase 1737983 dnaG 2650292 dnaG Corynebacterium diphtheriae NCTC 13129 DNA primase NP_940037.1 1736085 R 257309 CDS NP_940038.1 38234271 2650293 complement(1737994..1739871) 1 NC_002935.2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 1739871 glmS 2650293 glmS Corynebacterium diphtheriae NCTC 13129 glucosamine--fructose-6-phosphate aminotransferase NP_940038.1 1737994 R 257309 CDS NP_940039.1 38234272 2650294 1739962..1740420 1 NC_002935.2 Similar to Streptomyces aureofaciens guanyl-specific ribonuclease SA3 precursor RNAse3 SW:RNS3_STRAU (P30289) (141 aa) fasta scores: E(): 1.7e-10, 42.14% id in 140 aa; ribonuclease 1740420 2650294 DIP1701 Corynebacterium diphtheriae NCTC 13129 ribonuclease NP_940039.1 1739962 D 257309 CDS NP_940040.1 38234273 2650295 1740467..1740649 1 NC_002935.2 hypothetical protein 1740649 2650295 DIP1702 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940040.1 1740467 D 257309 CDS NP_940041.1 38234274 2650296 complement(1740639..1741910) 1 NC_002935.2 dGTPase type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein 1741910 2650296 DIP1703 Corynebacterium diphtheriae NCTC 13129 deoxyguanosinetriphosphate triphosphohydrolase-like protein NP_940041.1 1740639 R 257309 CDS NP_940042.1 38234275 2650297 complement(1741917..1742594) 1 NC_002935.2 hypothetical protein 1742594 2650297 DIP1704 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940042.1 1741917 R 257309 CDS NP_940043.1 38234276 2650298 1742648..1744654 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 70.0 kDa protein Rv2345 or MTCY98.14 TR:P95241 (EMBL:Z83860) (660 aa) fasta scores: E(): 1.6e-41, 30.4% id in 671 aa; hypothetical protein 1744654 2650298 DIP1705 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940043.1 1742648 D 257309 CDS NP_940044.1 38234277 2650299 complement(1744651..1745049) 1 NC_002935.2 hypothetical protein 1745049 2650299 DIP1706 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940044.1 1744651 R 257309 CDS NP_940045.1 38234278 2650300 complement(1745055..1745582) 1 NC_002935.2 hypothetical protein 1745582 2650300 DIP1707 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940045.1 1745055 R 257309 CDS NP_940046.1 38234279 2650301 complement(1745608..1746993) 1 NC_002935.2 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase 1746993 glyS 2650301 glyS Corynebacterium diphtheriae NCTC 13129 glycyl-tRNA synthetase NP_940046.1 1745608 R 257309 CDS NP_940047.1 38234280 2650302 1747304..1747681 1 NC_002935.2 Similar to Mycobacterium leprae ArsR-family transcriptional regulator ML0825 TR:Q9CCG5 (EMBL:AL583919) (140 aa) fasta scores: E(): 8.8e-08, 44.7% id in 85 aa, and to Sinorhizobium spAs4. ArsR TR:Q9RA93 (EMBL:AF178758) (115 aa) fasta scores: E(): 3.4e-05, 34.04% id in 94 aa; ArsR family transcriptional regulator 1747681 2650302 DIP1709 Corynebacterium diphtheriae NCTC 13129 ArsR family transcriptional regulator NP_940047.1 1747304 D 257309 CDS NP_940048.1 38234281 2650303 1747858..1748286 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 ferric uptake regulation protein MT2428 TR:AAK46722 (EMBL:AE007082) (130 aa) fasta scores: E(): 6.1e-24, 53.6% id in 125 aa, and to Escherichia coli ferric uptake regulation protein Fur or B0683 or Z0831 or ECS0714 SW:FUR_ECOLI (P06975) (148 aa) fasta scores: E(): 2.4e-10, 29.77% id in 131 aa; ferric uptake regulatory protein 1748286 2650303 DIP1710 Corynebacterium diphtheriae NCTC 13129 ferric uptake regulatory protein NP_940048.1 1747858 D 257309 CDS NP_940049.1 38234282 2650304 complement(1748293..1749288) 1 NC_002935.2 Similar to Pseudomonas aeruginosa hypothetical protein PA3851 TR:Q9HXF5 (EMBL:AE004802) (250 aa) fasta scores: E(): 9.2e-22, 38.29% id in 235 aa, and to Pyrococcus abyssi hypothetical 40.7 kDa protein PAB1273 TR:Q9UY73 (EMBL:AJ248288) (364 aa) fasta scores: E(): 1.3e-12, 28.69% id in 345 aa; hypothetical protein 1749288 2650304 DIP1711 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940049.1 1748293 R 257309 CDS NP_940050.1 38234283 2650305 complement(1749363..1750100) 1 NC_002935.2 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 1750100 2650305 DIP1712 Corynebacterium diphtheriae NCTC 13129 undecaprenyl pyrophosphate synthase NP_940050.1 1749363 R 257309 CDS NP_940051.1 38234284 2650306 complement(1750120..1750848) 1 NC_002935.2 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 1750848 recO 2650306 recO Corynebacterium diphtheriae NCTC 13129 DNA repair protein RecO NP_940051.1 1750120 R 257309 CDS NP_940052.1 38234285 2650307 complement(1750848..1751765) 1 NC_002935.2 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 1751765 era 2650307 era Corynebacterium diphtheriae NCTC 13129 GTP-binding protein Era NP_940052.1 1750848 R 257309 CDS NP_940053.1 38234286 2650308 complement(1751817..1752677) 1 NC_002935.2 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 1752677 2650308 DIP1715 Corynebacterium diphtheriae NCTC 13129 pyridoxamine kinase NP_940053.1 1751817 R 257309 CDS NP_940054.1 38234287 2650309 complement(1752679..1754007) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 47.2 kDa protein Rv2366c or MT2435 or MTCY27.14 SW:YN66_MYCTU (O05832) (435 aa) fasta scores: E(): 1.1e-67, 53.91% id in 434 aa; hypothetical protein 1754007 2650309 DIP1716 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940054.1 1752679 R 257309 CDS NP_940055.1 38234288 2650310 complement(1754004..1754594) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 19.7 kDa protein Rv2367c or MT2436 or MTCY27.13 SW:YN67_MYCTU (O05831) (177 aa) fasta scores: E(): 4.7e-40, 69.33% id in 150 aa; metalloprotease 1754594 2650310 DIP1717 Corynebacterium diphtheriae NCTC 13129 metalloprotease NP_940055.1 1754004 R 257309 CDS NP_940056.1 38234289 2650311 complement(1754595..1755563) 1 NC_002935.2 Similar to Mycobacterium tuberculosis PhoH-like protein Rv2368c or MT2437 or MTCY27.12 SW:PHOL_MYCTU (O05830) (352 aa) fasta scores: E(): 2.2e-66, 63.25% id in 313 aa, and to Bacillus subtilis PhoH-like protein PhoH SW:PHOL_BACSU (P46343) (319 aa) fasta scores: E(): 2.9e-52, 52.47% id in 303 aa; PhoH-like protein 1755563 2650311 DIP1718 Corynebacterium diphtheriae NCTC 13129 PhoH-like protein NP_940056.1 1754595 R 257309 CDS NP_940057.1 38234290 2650312 complement(1755611..1756369) 1 NC_002935.2 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 1756369 2650312 DIP1719 Corynebacterium diphtheriae NCTC 13129 16S ribosomal RNA methyltransferase RsmE NP_940057.1 1755611 R 257309 CDS NP_940058.1 38234291 2650313 complement(1756371..1757498) 1 NC_002935.2 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 1757498 dnaJ2 2650313 dnaJ2 Corynebacterium diphtheriae NCTC 13129 molecular chaperone DnaJ NP_940058.1 1756371 R 257309 CDS NP_940059.1 38234292 2650314 complement(1757572..1758609) 1 NC_002935.2 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 1758609 hrcA 2650314 hrcA Corynebacterium diphtheriae NCTC 13129 heat-inducible transcription repressor NP_940059.1 1757572 R 257309 CDS NP_940060.1 38234293 2650315 complement(1758649..1759782) 1 NC_002935.2 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 1759782 hemN 2650315 hemN Corynebacterium diphtheriae NCTC 13129 coproporphyrinogen III oxidase NP_940060.1 1758649 R 257309 CDS NP_940061.1 38234294 2650316 complement(1759772..1760443) 1 NC_002935.2 hypothetical protein 1760443 2650316 DIP1723 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940061.1 1759772 R 257309 CDS NP_940062.1 38234295 2650317 complement(1760582..1763809) 1 NC_002935.2 No significant database matches. Note: Contains a potential sortase anchor site (LANTG) upstream of the C-terminal region transmembrane domain. Contains also a twin-arginine translocation (TAT) system recognition motif (RRVFAS) at the N-terminal region. Also similar to DIP0439, DIP0442, DIP2325 and DIP0443; surface-anchored membrane protein 1763809 2650317 DIP1724 Corynebacterium diphtheriae NCTC 13129 surface-anchored membrane protein NP_940062.1 1760582 R 257309 CDS NP_940063.1 38234296 2650318 complement(1763886..1765715) 1 NC_002935.2 Similar to Mycobacterium tuberculosis long-chain-fatty-acid-CoA ligase FadD15 or Rv2187 or MTV021.20 TR:O53521 (EMBL:AL021957) (600 aa) fasta scores: E(): 9.3e-80, 46.48% id in 611 aa, and to Streptomyces coelicolor long chain fatty acid CoA ligase SC6G10.04 TR:Q9X7Z0 (EMBL:AL049497) (598 aa) fasta scores: E(): 1.7e-78, 46.72% id in 610 aa; long-chain-fatty-acid-CoA ligase 1765715 2650318 DIP1725 Corynebacterium diphtheriae NCTC 13129 long-chain-fatty-acid-CoA ligase NP_940063.1 1763886 R 257309 CDS NP_940064.1 38234297 2650319 1765812..1767980 1 NC_002935.2 Similar to Mycobacterium tuberculosis 4-alpha-glucanotransferase MalQ or Rv1781c or MT1831 or MTV049.03c SW:MALQ_MYCTU (O53932) (724 aa) fasta scores: E(): 7.8e-73, 45.87% id in 728 aa, and to Escherichia coli 4-alpha-glucanotransferase MalQ or MalA or B3416 SW:MALQ_ECOLI (P15977) (694 aa) fasta scores: E(): 1.2e-29, 28.48% id in 660 aa; glucanotransferase 1767980 2650319 DIP1726 Corynebacterium diphtheriae NCTC 13129 glucanotransferase NP_940064.1 1765812 D 257309 CDS NP_940065.1 38234298 2650320 complement(1768127..1768330) 1 NC_002935.2 hypothetical protein 1768330 2650320 DIP1727 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940065.1 1768127 R 257309 CDS NP_940066.1 38234299 2650321 complement(1768327..1770306) 1 NC_002935.2 Similar to Escherichia coli peptidyl-dipeptidase Dcp or B1538 SW:DCP_ECOLI (P24171) (680 aa) fasta scores: E(): 6.5e-63, 38.52% id in 680 aa, and to Escherichia coli oligopeptidase A PrlC or OpdA or B3498 SW:OPDA_ECOLI (P27298) (680 aa) fasta scores: E(): 1.8e-37, 31.35% id in 689 aa; peptidase 1770306 2650321 DIP1728 Corynebacterium diphtheriae NCTC 13129 peptidase NP_940066.1 1768327 R 257309 CDS NP_940067.1 38234300 2650322 1770335..1771534 1 NC_002935.2 Similar to Streptomyces coelicolor carboxylesterase SC5G9.30 TR:Q9RKZ7 (EMBL:AL117385) (518 aa) fasta scores: E(): 3.2e-14, 30.57% id in 363 aa, and to Bacillus subtilis para-nitrobenzyl esterase PnbA SW:PNBA_BACSU (P37967) (489 aa) fasta scores: E(): 7.3e-12, 28.22% id in 372 aa; hydrolase 1771534 2650322 DIP1729 Corynebacterium diphtheriae NCTC 13129 hydrolase NP_940067.1 1770335 D 257309 CDS NP_940068.1 38234301 2650323 complement(1771521..1772072) 1 NC_002935.2 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 1772072 idi 2650323 idi Corynebacterium diphtheriae NCTC 13129 isopentenyl-diphosphate delta-isomerase NP_940068.1 1771521 R 257309 CDS NP_940069.1 38234302 2650324 complement(1772091..1773665) 1 NC_002935.2 hypothetical protein 1773665 2650324 DIP1731 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940069.1 1772091 R 257309 CDS NP_940070.1 38234303 2650325 complement(1773666..1774244) 1 NC_002935.2 hypothetical protein 1774244 2650325 DIP1732 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940070.1 1773666 R 257309 CDS NP_940071.1 38234304 2650326 complement(1774501..1775658) 1 NC_002935.2 hypothetical protein 1775658 2650326 DIP1733 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940071.1 1774501 R 257309 CDS NP_940072.1 38234305 2650327 complement(1775840..1776250) 1 NC_002935.2 hypothetical protein 1776250 2650327 DIP1734 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940072.1 1775840 R 257309 CDS NP_940073.1 38234306 2650328 1776468..1778315 1 NC_002935.2 Similar to Amycolatopsis orientalis hypothetical 71.1 kDa protein PCZA363.2 CZA382.30 TR:O52818 (EMBL:AJ223999) (650 aa) fasta scores: E(): 1.8e-39, 30.58% id in 618 aa; ABC transporter ATP-binding protein 1778315 2650328 DIP1735 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_940073.1 1776468 D 257309 CDS NP_940074.1 38234307 2650329 1778334..1779464 1 NC_002935.2 Similar to Corynebacterium glutamicum beta C-S lyase AecD TR:Q46061 (EMBL:M89931) (325 aa) fasta scores: E(): 3e-66, 53.93% id in 330 aa; beta C-S lyase 1779464 aecD 2650329 aecD Corynebacterium diphtheriae NCTC 13129 beta C-S lyase NP_940074.1 1778334 D 257309 CDS NP_940075.1 38234308 2650330 1779545..1780849 1 NC_002935.2 Similar to Corynebacterium glutamicum branched-chain amino acid transport system carrier protein BrnQ SW:BRNQ_CORGL (O06754) (426 aa) fasta scores: E(): 8.7e-50, 53.09% id in 420 aa, and to Escherichia coli branched-chain amino acid transport system II carrier protein BrnQ or B0401 or Z0499 or ECS0451 SW:BRNQ_ECOLI (P37011) (439 aa) fasta scores: E(): 2.4e-40, 33.17% id in 431 aa; branched-chain amino acid ABC transport system membrane protein 1780849 brnQ 2650330 brnQ Corynebacterium diphtheriae NCTC 13129 branched-chain amino acid ABC transport system membrane protein NP_940075.1 1779545 D 257309 CDS NP_940076.1 38234309 2650331 1780859..1781812 1 NC_002935.2 Similar to Agrobacterium tumefaciens StrC58 AGR_l_2217p TR:AAK89679 (EMBL:AE008310) (333 aa) fasta scores: E(): 5.1e-42, 45.79% id in 321 aa; hypothetical protein 1781812 2650331 DIP1738 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940076.1 1780859 D 257309 CDS NP_940077.1 38234310 2650332 complement(1781790..1783616) 1 NC_002935.2 Similar to Corynebacterium glutamicum EctP protein (Transport of ectoine, glycine betaine, proline) TR:O86143 (EMBL:AJ001436) (615 aa) fasta scores: E(): 5.2e-181, 73.23% id in 609 aa, and to Bacillus subtilis glycine betaine transporter OpuD SW:OPUD_BACSU (P54417) (512 aa) fasta scores: E(): 2.4e-65, 38.35% id in 511 aa; ectoine, glycine betaine and proline transport system membrane protein 1783616 ectP 2650332 ectP Corynebacterium diphtheriae NCTC 13129 ectoine, glycine betaine and proline transport system membrane protein NP_940077.1 1781790 R 257309 CDS NP_940078.1 38234311 2650333 1783772..1785298 1 NC_002935.2 Similar to Rhizobium loti dipeptide-binding protein of ABC transporter MLR1186 TR:Q98L42 (EMBL:AP002996) (497 aa) fasta scores: E(): 8e-52, 34.96% id in 449 aa; ABC transporter substrate-binding protein 1785298 2650333 DIP1740 Corynebacterium diphtheriae NCTC 13129 ABC transporter substrate-binding protein NP_940078.1 1783772 D 257309 CDS NP_940079.1 38234312 2650334 1785305..1786252 1 NC_002935.2 Similar to Rhizobium loti permease of oligopeptide ABC transporter MLR1187 TR:Q98L41 (EMBL:AP002996) (315 aa) fasta scores: E(): 1.3e-43, 42.2% id in 308 aa, and to Bacillus subtilis oligopeptide transport system permease AppB SW:APPB_BACSU (P42062) (317 aa) fasta scores: E(): 2e-35, 35.93% id in 320 aa; oligopeptide ABC transport system membrane protein 1786252 2650334 DIP1741 Corynebacterium diphtheriae NCTC 13129 oligopeptide ABC transport system membrane protein NP_940079.1 1785305 D 257309 CDS NP_940080.1 38234313 2649367 1786256..1787077 1 NC_002935.2 Similar to Rhizobium loti permease of oligopeptide ABC transporter MLR1189 TR:Q98L40 (EMBL:AP002996) (289 aa) fasta scores: E(): 1.8e-49, 52.1% id in 261 aa, and to Escherichia coli dipeptide transport system permease DppC or B3542 or Z4959 or ECS4422 SW:DPPC_ECOLI (P37315) (300 aa) fasta scores: E(): 5e-36, 42.96% id in 270 aa; oligopeptide ABC transport system membrane protein 1787077 2649367 DIP1742 Corynebacterium diphtheriae NCTC 13129 oligopeptide ABC transport system membrane protein NP_940080.1 1786256 D 257309 CDS NP_940081.1 38234314 2649368 1787074..1788516 1 NC_002935.2 Similar to Streptomyces coelicolor oligopeptide ABC transporter ATP-binding protein SCBAC1A6.35c TR:Q9ADF2 (EMBL:AL589708) (585 aa) fasta scores: E(): 1.2e-33, 44.29% id in 526 aa; ABC transporter ATP-binding protein 1788516 2649368 DIP1743 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_940081.1 1787074 D 257309 CDS NP_940082.1 38234315 2649369 complement(1788659..1789873) 1 NC_002935.2 Similar to Streptomyces coelicolor prolyl aminopeptidase SCF43.16c TR:Q9RD72 (EMBL:AL136502) (433 aa) fasta scores: E(): 5e-44, 41.16% id in 396 aa, and to Aeromonas sobria proline iminopeptidase Pip or Pap SW:PIP_AERSO (P46547) (424 aa) fasta scores: E(): 8e-26, 40.25% id in 395 aa; prolyl aminopeptidase 1789873 2649369 DIP1744 Corynebacterium diphtheriae NCTC 13129 prolyl aminopeptidase NP_940082.1 1788659 R 257309 CDS NP_940083.1 38234316 2649370 1789874..1790539 1 NC_002935.2 Similar to Xylella fastidiosa hypothetical protein XF1717 TR:Q9PCR1 (EMBL:AE003995) (266 aa) fasta scores: E(): 1.7e-28, 46.22% id in 225 aa; hypothetical protein 1790539 2649370 DIP1745 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940083.1 1789874 D 257309 CDS NP_940084.1 38234317 2649371 1790536..1791924 1 NC_002935.2 Similar to Escherichia coli xylulose kinase XylB or B3564 SW:XYLB_ECOLI (P09099) (484 aa) fasta scores: E(): 6.8e-22, 30.57% id in 471 aa; xylulose kinase 1791924 2649371 DIP1746 Corynebacterium diphtheriae NCTC 13129 xylulose kinase NP_940084.1 1790536 D 257309 CDS NP_940085.1 38234318 2649372 1791955..1792185 1 NC_002935.2 hypothetical protein 1792185 2649372 DIP1747 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940085.1 1791955 D 257309 CDS NP_940086.1 38234319 2649373 1792489..1794102 1 NC_002935.2 Similar to Lactococcus lactis NADH oxidase NoxC TR:Q9CHE6 (EMBL:AE006312) (547 aa) fasta scores: E(): 5.8e-81, 44.95% id in 545 aa, and to Enterococcus faecalis NADH oxidase Nox SW:NAOX_ENTFA (P37061) (446 aa) fasta scores: E(): 3.8e-30, 27.46% id in 437 aa; oxidase 1794102 2649373 DIP1748 Corynebacterium diphtheriae NCTC 13129 oxidase NP_940086.1 1792489 D 257309 CDS NP_940087.1 38234320 2649374 1794114..1794371 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 10.2 kDa protein SCF56.04c TR:Q9RD62 (EMBL:AL133424) (92 aa) fasta scores: E(): 4.6e-13, 52.22% id in 90 aa; hypothetical protein 1794371 2649374 DIP1749 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940087.1 1794114 D 257309 CDS NP_940088.1 38234321 2649375 complement(1794357..1795889) 1 NC_002935.2 Similar to Vibrio cholerae glutathione-regulated potassium-efflux system protein KefB, VC0992 TR:Q9KTB1 (EMBL:AE004180) (528 aa) fasta scores: E(): 1.3e-37, 33.26% id in 514 aa; potassium transport related membrane protein 1795889 2649375 DIP1750 Corynebacterium diphtheriae NCTC 13129 potassium transport related membrane protein NP_940088.1 1794357 R 257309 CDS NP_940089.1 38234322 2649376 1795929..1796147 1 NC_002935.2 hypothetical protein 1796147 2649376 DIP1751 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940089.1 1795929 D 257309 CDS NP_940090.1 38234323 2649377 1796249..1797652 1 NC_002935.2 Similar to Lactococcus lactis multidrug transporter YqiA TR:Q9CF47 (EMBL:AE006394) (476 aa) fasta scores: E(): 1.5e-87, 58.69% id in 460 aa, and to Streptomyces glaucescens tetracenomycin C resistance and export protein TcmA SW:TCMA_STRGA (P39886) (538 aa) fasta scores: E(): 3.8e-15, 24.88% id in 422 aa; antibiotic ABC transporter 1797652 2649377 DIP1752 Corynebacterium diphtheriae NCTC 13129 antibiotic ABC transporter NP_940090.1 1796249 D 257309 CDS NP_940091.1 38234324 2649378 1797649..1798587 1 NC_002935.2 Similar to Crithidia fasciculata inosine-uridine preferring nucleoside hydrolase IunH SW:IUNH_CRIFA (Q27546) (314 aa) fasta scores: E(): 2.3e-73, 64.19% id in 310 aa; inosine-uridine preferring nucleoside hydrolase 1798587 iunH 2649378 iunH Corynebacterium diphtheriae NCTC 13129 inosine-uridine preferring nucleoside hydrolase NP_940091.1 1797649 D 257309 CDS NP_940092.1 38234325 2649379 1798593..1799399 1 NC_002935.2 Similar to Streptomyces coelicolor integral membrane protein SC4A2.12 TR:O86668 (EMBL:AL031182) (299 aa) fasta scores: E(): 9.2e-18, 34.31% id in 271 aa; hypothetical protein 1799399 2649379 DIP1754 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940092.1 1798593 D 257309 CDS NP_940093.1 38234326 2649380 1799436..1800095 1 NC_002935.2 hypothetical protein 1800095 2649380 DIP1755 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940093.1 1799436 D 257309 CDS NP_940094.1 38234327 2649381 1800239..1803019 1 NC_002935.2 Similar to Neisseria meningitidis hypothetical protein NMA1791 TR:Q9JTG2 (EMBL:AL162757) (803 aa) fasta scores: E(): 1.8e-94, 40.58% id in 818 aa, and to Deinococcus radiodurans DNA modification methyltransferase-related protein DR2267 TR:Q9RS60 (EMBL:AE002059) (840 aa) fasta scores: E(): 1.8e-15, 25.93% id in 879 aa; DNA methyltransferase 1803019 2649381 DIP1756 Corynebacterium diphtheriae NCTC 13129 DNA methyltransferase NP_940094.1 1800239 D 257309 CDS NP_940095.1 38234328 2649382 1803016..1803906 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 Mrr restriction system protein MT2603 TR:AAK46913 (EMBL:AE007096) (306 aa) fasta scores: E(): 1.1e-06, 25.67% id in 261 aa, and to Escherichia coli restriction system protein Mrr or B4351 SW:MRR_ECOLI (P24202) (304 aa) fasta scores: E(): 0.015, 23.68% id in 266 aa. Note: In E.coli this ORF is involved in acceptance of foreign DNA which is modified, restricting both adenine and cytosime methylated DNA; Mrr restriction system protein 1803906 2649382 DIP1757 Corynebacterium diphtheriae NCTC 13129 Mrr restriction system protein NP_940095.1 1803016 D 257309 CDS NP_940096.1 38234329 2649383 complement(1803982..1804326) 1 NC_002935.2 Doubtful CDS. No significant database matches; hypothetical protein 1804326 2649383 DIP1758 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940096.1 1803982 R 257309 CDS NP_940097.1 38234330 2649384 complement(1804436..1805272) 1 NC_002935.2 Similar to Pasteurella multocida hypothetical protein PM1540 TR:Q9CKR6 (EMBL:AE006190) (309 aa) fasta scores: E(): 3.2e-26, 35.98% id in 239 aa, and to Staphylococcus aureus hypothetical protein SAV0801 TR:BAB56963 (EMBL:AP003360) (322 aa) fasta scores: E(): 1.6e-06, 22.13% id in 244 aa; hypothetical protein 1805272 2649384 DIP1759 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940097.1 1804436 R 257309 CDS NP_940098.1 38234331 2649385 complement(1805322..1805507) 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 1805507 2649385 DIP1760 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940098.1 1805322 R 257309 CDS NP_940099.1 38234332 2649386 1805784..1806617 1 NC_002935.2 hypothetical protein 1806617 2649386 DIP1761 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940099.1 1805784 D 257309 CDS NP_940100.1 38234333 2649387 1806618..1807301 1 NC_002935.2 Poor database matches. Weakly similar to Streptomyces coelicolor hypothetical protein SCI41.33c TR:O87592 (EMBL:AF086832) (196 aa) fasta scores: E(): 8.3, 24.27% id in 173 aa; hypothetical protein 1807301 2649387 DIP1762 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940100.1 1806618 D 257309 CDS NP_940101.1 38234334 2649388 complement(1807896..1809062) 1 NC_002935.2 Similar to Corynebacterium glutamicum hypothetical protein CGL1238 SWALL:Q8NR26 (EMBL:AP005277) (383 aa) fasta scores: E(): 4.8e-30, 31.77% id in 384 aa, and to Bifidobacterium longum NCC2705 hypothetical protein BL0662 SWALL:AAN24484 (EMBL:AE014688) (368 aa) fasta scores: E(): 4.5e-20, 39.73% id in 380 aa; hypothetical protein 1809062 2649388 DIP1763 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940101.1 1807896 R 257309 CDS NP_940102.1 38234335 2649389 complement(1809198..1811045) 1 NC_002935.2 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 1811045 lepA 2649389 lepA Corynebacterium diphtheriae NCTC 13129 GTP-binding protein LepA NP_940102.1 1809198 R 257309 CDS NP_940103.1 38234336 2649390 1811324..1811881 1 NC_002935.2 Poor database matches. C-terminal region is similar to Mycobacterium tuberculosis hypothetical protein Rv2405 TR:P71738 (EMBL:Z81368) (189 aa) fasta scores: E(): 1.9e-22, 43.7% id in 135 aa. Possible alternative translational start site; hypothetical protein 1811881 2649390 DIP1765 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940103.1 1811324 D 257309 CDS NP_940104.1 38234337 2649391 1812042..1812305 1 NC_002935.2 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 1812305 rpsT 2649391 rpsT Corynebacterium diphtheriae NCTC 13129 30S ribosomal protein S20 NP_940104.1 1812042 D 257309 CDS NP_940105.1 38234338 2649392 complement(1812354..1812992) 1 NC_002935.2 Similar to Escherichia coli threonine efflux protein RhtC SW:RHTC_ECOLI (P27846) (206 aa) fasta scores: E(): 2.7e-18, 30.43% id in 207 aa, and to Salmonella typhimurium LT2 threonine efflux protein RhtC TR:Q9L6N7 (EMBL:AF233324) (206 aa) fasta scores: E(): 1.7e-18, 30.88% id in 204 aa; LysE type translocator 1812992 2649392 DIP1767 Corynebacterium diphtheriae NCTC 13129 LysE type translocator NP_940105.1 1812354 R 257309 CDS NP_940106.1 38234339 2649393 complement(1812982..1813383) 1 NC_002935.2 Similar to Streptomyces coelicolor ankyrin-like protein SC6D7.25 TR:Q9RKX3 (EMBL:AL133213) (134 aa) fasta scores: E(): 4.4e-23, 57.36% id in 129 aa, and to Campylobacter jejuni ankyrin-repeat containing protein Cj1386 TR:Q9PMR4 (EMBL:AL139078) (156 aa) fasta scores: E(): 1.2e-10, 39.66% id in 121 aa; hypothetical protein 1813383 2649393 DIP1768 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940106.1 1812982 R 257309 CDS NP_940107.1 38234340 2649394 complement(1813394..1814368) 1 NC_002935.2 required for the assembly and function of the DNAX complex which are required fro the assembly of the beta subunit onto primed DNA; hypothetical protein 1814368 2649394 DIP1769 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940107.1 1813394 R 257309 CDS NP_940108.1 38234341 2649395 complement(1814322..1815995) 1 NC_002935.2 Poor database matches. Weakly similar to Mycobacterium tuberculosis hypothetical protein Rv2414c TR:P71729 (EMBL:Z81368) (514 aa) fasta scores: E(): 7.8e-27, 33.81% id in 482 aa; hypothetical protein 1815995 2649395 DIP1770 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940108.1 1814322 R 257309 CDS NP_940109.1 38234342 2649396 complement(1815992..1816621) 1 NC_002935.2 No significant database matches to the full length CDS. C-terminus is similar to the C-terminal regions of Bacillus halodurans late competence operon required for DNA binding and uptake BH1333 TR:Q9KD84 (EMBL:AP001511) (210 aa) fasta scores: E(): 0.00087, 40.55% id in 143 aa, and Streptomyces coelicolor DNA-binding protein SCC123.06c TR:Q9RDL8 (EMBL:AL136518) (355 aa) fasta scores: E(): 3e-06, 40.93% id in 193 aa; hypothetical protein 1816621 2649396 DIP1771 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940109.1 1815992 R 257309 CDS NP_940110.1 38234343 2649397 complement(1816728..1817549) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical protein Rv2417c TR:P71726 (EMBL:Z81368) (280 aa) fasta scores: E(): 1e-21, 34.92% id in 272 aa, and to Streptomyces coelicolor hypothetical protein SCC123.07c TR:Q9RDL7 (EMBL:AL136518) (281 aa) fasta scores: E(): 6e-21, 36.13% id in 274 aa; hypothetical protein 1817549 2649397 DIP1772 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940110.1 1816728 R 257309 CDS NP_940111.1 38234344 2649398 complement(1817554..1818276) 1 NC_002935.2 Similar to Mycobacterium leprae possible phosphoglycerate mutase ML1452 TR:Q9CC00 (EMBL:AL583922) (224 aa) fasta scores: E(): 1.1e-34, 44.26% id in 244 aa, and to Mycobacterium tuberculosis hypothetical protein Rv2419c TR:P71724 (EMBL:Z81368) (223 aa) fasta scores: E(): 6.3e-34, 52.88% id in 191 aa; phosphoglycerate mutase 1818276 2649398 DIP1773 Corynebacterium diphtheriae NCTC 13129 phosphoglycerate mutase NP_940111.1 1817554 R 257309 CDS NP_940112.1 38234345 2649399 complement(1818283..1818750) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical protein SCC123.15c TR:Q9RDK9 (EMBL:AL136518) (148 aa) fasta scores: E(): 1.7e-21, 50.34% id in 145 aa, and to Mycobacterium tuberculosis hypothetical protein Rv2420c TR:O86327 (EMBL:Z81368) (126 aa) fasta scores: E(): 4.5e-20, 50.42% id in 117 aa; hypothetical protein 1818750 2649399 DIP1774 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940112.1 1818283 R 257309 CDS NP_940113.1 38234346 2649400 complement(1818773..1819459) 1 NC_002935.2 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 1819459 nadD 2649400 nadD Corynebacterium diphtheriae NCTC 13129 nicotinic acid mononucleotide adenylyltransferase NP_940113.1 1818773 R 257309 CDS NP_940114.1 38234347 2649401 complement(1819483..1820775) 1 NC_002935.2 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 1820775 proA 2649401 proA Corynebacterium diphtheriae NCTC 13129 gamma-glutamyl phosphate reductase NP_940114.1 1819483 R 257309 CDS NP_940115.1 38234348 2649402 complement(1820793..1821923) 1 NC_002935.2 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 1821923 proB 2649402 proB Corynebacterium diphtheriae NCTC 13129 gamma-glutamyl kinase NP_940115.1 1820793 R 257309 CDS NP_940116.1 38234349 2649403 complement(1821944..1822195) 1 NC_002935.2 No significant database matches. Doubtful CDS; hypothetical protein 1822195 2649403 DIP1778 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940116.1 1821944 R 257309 CDS NP_940117.1 38234350 2649404 complement(1822199..1823725) 1 NC_002935.2 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 1823725 obgE 2649404 obgE Corynebacterium diphtheriae NCTC 13129 GTPase ObgE NP_940117.1 1822199 R 257309 CDS NP_940118.1 38234351 2649405 complement(1823886..1824152) 1 NC_002935.2 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1824152 rpmA 2649405 rpmA Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L27 NP_940118.1 1823886 R 257309 CDS NP_940119.1 38234352 2649406 complement(1824193..1824498) 1 NC_002935.2 Similar to Escherichia coli 50S ribosomal protein L21 RplU SW:RL21_ECOLI (P02422) (103 aa) fasta scores: E(): 1.5e-10, 38.61% id in 101 aa, and to Mycobacterium leprae 50S ribosomal protein L21 ML1467 SW:RL21_MYCLE (Q9CBZ2) (103 aa) fasta scores: E(): 5.7e-23, 71% id in 100 aa; 50S ribosomal protein L21 1824498 rplU 2649406 rplU Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L21 NP_940119.1 1824193 R 257309 CDS NP_940120.1 38234353 2649407 complement(1824673..1827561) 1 NC_002935.2 C-terminus is similar to the N-terminal region of Escherichia coli ribonuclease E Rne SW:RNE_ECOLI (P21513) (1061 aa) fasta scores: E(): 5.5e-38, 33.08% id in 659 aa. Full length CDS is similar to Mycobacterium leprae possible ribonuclease ML1468 TR:Q9CBZ1 (EMBL:AL583922) (924 aa) fasta scores: E(): 1.1e-107, 47.24% id in 853 aa; RNA-associated protein 1827561 2649407 DIP1782 Corynebacterium diphtheriae NCTC 13129 RNA-associated protein NP_940120.1 1824673 R 257309 CDS NP_940121.1 38234354 2649408 complement(1827843..1828277) 1 NC_002935.2 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 1828277 ndk 2649408 ndk Corynebacterium diphtheriae NCTC 13129 nucleoside diphosphate kinase NP_940121.1 1827843 R 257309 CDS NP_940122.1 38234355 2649409 complement(1828445..1828858) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical protein Rv2446c TR:O53173 (EMBL:AL021246) (123 aa) fasta scores: E(): 1.5e-07, 31.35% id in 118 aa, and to Mycobacterium leprae conserved membrane protein ML1470 TR:Q9CBY9 (EMBL:AL583922) (123 aa) fasta scores: E(): 4.9e-07, 30.46% id in 128 aa; hypothetical protein 1828858 2649409 DIP1784 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940122.1 1828445 R 257309 CDS NP_940123.1 38234356 2649410 complement(1828855..1830351) 1 NC_002935.2 Similar to Mycobacterium tuberculosis folylpolyglutamate synthase Rv2447c TR:O53174 (EMBL:AL021246) (487 aa) fasta scores: E(): 1.2e-100, 57.46% id in 496 aa, and to Mycobacterium leprae folylpolyglutamate synthase ML1471 TR:Q9CBY8 (EMBL:AL583922) (485 aa) fasta scores: E(): 3.8e-96, 56.17% id in 470 aa; Mur ligase 1830351 2649410 DIP1785 Corynebacterium diphtheriae NCTC 13129 Mur ligase NP_940123.1 1828855 R 257309 CDS NP_940124.1 38234357 2649411 complement(1830348..1833107) 1 NC_002935.2 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 1833107 valS 2649411 valS Corynebacterium diphtheriae NCTC 13129 valyl-tRNA synthetase NP_940124.1 1830348 R 257309 CDS NP_940125.1 38234358 2649412 complement(1833151..1834131) 1 NC_002935.2 catalyzes the oxidation of malate to oxaloacetate; malate dehydrogenase 1834131 mdh 2649412 mdh Corynebacterium diphtheriae NCTC 13129 malate dehydrogenase NP_940125.1 1833151 R 257309 CDS NP_940126.1 38234359 2649413 1834614..1835366 1 NC_002935.2 Similar to Rhizobium meliloti transcription regulator protein SMC04134 TR:CAC41505 (EMBL:AL591782) (225 aa) fasta scores: E(): 3.4e-17, 30.8% id in 198 aa, and to Caulobacter crescentus TetR family transcriptional regulator CC2608 TR:Q9A556 (EMBL:AE005928) (230 aa) fasta scores: E(): 4e-13, 31.7% id in 205 aa; TetR family regulatory protein 1835366 2649413 DIP1788 Corynebacterium diphtheriae NCTC 13129 TetR family regulatory protein NP_940126.1 1834614 D 257309 CDS NP_940127.1 38234360 2649414 complement(1835403..1836695) 1 NC_002935.2 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 1836695 clpX 2649414 clpX Corynebacterium diphtheriae NCTC 13129 ATP-dependent protease ATP-binding subunit ClpX NP_940127.1 1835403 R 257309 CDS NP_940128.1 38234361 2649415 complement(1836842..1839373) 1 NC_002935.2 N-terminal region is similar to Streptomyces griseus para-aminobenzoate synthase Pab SW:PABS_STRGR (P32483) (723 aa) fasta scores: E(): 1.8e-48, 39.11% id in 698 aa, and to Streptomyces pristinaespiralis p-aminobenzoate synthase PapA TR:P72539 (EMBL:U60417) (719 aa) fasta scores: E(): 6.1e-43, 35.83% id in 734 aa; glutamine amidotransferase 1839373 2649415 DIP1790 Corynebacterium diphtheriae NCTC 13129 glutamine amidotransferase NP_940128.1 1836842 R 257309 CDS NP_940129.1 38234362 2649416 complement(1839462..1840091) 1 NC_002935.2 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 1840091 clpP2 2649416 clpP2 Corynebacterium diphtheriae NCTC 13129 ATP-dependent Clp protease proteolytic subunit NP_940129.1 1839462 R 257309 CDS NP_940130.1 38234363 2649417 complement(1840109..1840708) 1 NC_002935.2 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 1840708 clpP 2649417 clpP Corynebacterium diphtheriae NCTC 13129 ATP-dependent Clp protease proteolytic subunit NP_940130.1 1840109 R 257309 CDS NP_940131.1 38234364 2649418 complement(1840874..1842220) 1 NC_002935.2 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 1842220 tig 2649418 tig Corynebacterium diphtheriae NCTC 13129 trigger factor NP_940131.1 1840874 R 257309 CDS NP_940132.1 38234365 2649421 1843047..1843283 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 1843283 2649421 DIP1794 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940132.1 1843047 D 257309 CDS NP_940133.1 38234366 2649422 1843430..1844212 1 NC_002935.2 Poor database matches. Similar to the C-terminal region of Streptomyces coelicolor secreted protein SC1C2.11 TR:O86512 (EMBL:AL031124) (450 aa) fasta scores: E(): 0.47, 27.13% id in 269 aa; hypothetical protein 1844212 2649422 DIP1795 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940133.1 1843430 D 257309 CDS NP_940134.1 38234367 2649423 complement(1844289..1844762) 1 NC_002935.2 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B 1844762 2649423 DIP1796 Corynebacterium diphtheriae NCTC 13129 ribose-5-phosphate isomerase B NP_940134.1 1844289 R 257309 CDS NP_940135.1 38234368 2649424 complement(1844794..1845414) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical protein Rv2466c TR:O53193 (EMBL:AL021246) (207 aa) fasta scores: E(): 2.5e-43, 57.63% id in 203 aa, and to Mycobacterium leprae hypothetical protein ML1485 TR:Q9CBY0 (EMBL:AL583922) (207 aa) fasta scores: E(): 1.7e-40, 55.94% id in 202 aa; hypothetical protein 1845414 2649424 DIP1797 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940135.1 1844794 R 257309 CDS NP_940136.1 38234369 2649425 1845536..1848154 1 NC_002935.2 Similar to Streptomyces lividans aminopeptidase N PepN SW:AMPN_STRLI (Q11010) (857 aa) fasta scores: E(): 1.2e-88, 45.27% id in 888 aa, and to Mycobacterium tuberculosis aminopeptidase Rv2467 TR:O53194 (EMBL:AL021246) (861 aa) fasta scores: E(): 1.9e-132, 51.97% id in 885 aa. CDS appears to be extended at the N-terminus in comparison to orthologues. Possible alternative translational start site, although current start has better RBS and extented region contains Pfam hit; aminopeptidase 1848154 2649425 DIP1798 Corynebacterium diphtheriae NCTC 13129 aminopeptidase NP_940136.1 1845536 D 257309 CDS NP_940137.1 38234370 2649426 1848410..1849426 1 NC_002935.2 C-terminus is similar to thye C-terminal region of Streptomyces coelicolor hypothetical protein SCF43A.26C TR:Q9XA89 (EMBL:AL096837) (333 aa) fasta scores: E(): 1.4e-38, 41.75% id in 297 aa. Similar to an internal region of Streptomyces coelicolor membrane protein SC8E4A.26 TR:Q9L1X9 (EMBL:AL138662) (408 aa) fasta scores: E(): 2.7e-28, 38.41% id in 302 aa; mechanosensitive ion channel protein MscS 1849426 2649426 DIP1799 Corynebacterium diphtheriae NCTC 13129 mechanosensitive ion channel protein MscS NP_940137.1 1848410 D 257309 CDS NP_940138.1 38234371 2649427 1849438..1849830 1 NC_002935.2 Similar to Mycobacterium tuberculosis hemoglobin-like protein Rv2470 TR:O53197 (EMBL:AL021246) (128 aa) fasta scores: E(): 6.5e-24, 51.61% id in 124 aa, and to Mycobacterium leprae hemoglobin-like protein ML1253 TR:Q9CC59 (EMBL:AL583921) (128 aa) fasta scores: E(): 5.9e-23, 50.8% id in 124 aa; hemoglobin 1849830 2649427 DIP1800 Corynebacterium diphtheriae NCTC 13129 hemoglobin NP_940138.1 1849438 D 257309 CDS NP_940139.1 38234372 2649428 complement(1849827..1850447) 1 NC_002935.2 Limited database matches. Similar to Mycobacterium tuberculosis hypothetical protein Rv2474c TR:O53201 (EMBL:AL021246) (217 aa) fasta scores: E(): 2.2e-14, 39.59% id in 197 aa; hypothetical protein 1850447 2649428 DIP1801 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940139.1 1849827 R 257309 CDS NP_940140.1 38234373 2649429 complement(1850457..1850900) 1 NC_002935.2 Similar to Halobacterium sp hypothetical protein VNG1407C TR:Q9HPZ1 (EMBL:AE005058) (132 aa) fasta scores: E(): 2.8e-09, 37.06% id in 116 aa, and to Pseudomonas aeruginosa hypothetical protein PA2801 TR:Q9I042 (EMBL:AE004707) (134 aa) fasta scores: E(): 4e-07, 35.38% id in 130 aa; hypothetical protein 1850900 2649429 DIP1802 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940140.1 1850457 R 257309 CDS NP_940141.1 38234374 2649430 complement(1851027..1852697) 1 NC_002935.2 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein 1852697 2649430 DIP1803 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_940141.1 1851027 R 257309 CDS NP_940142.1 38234375 2649431 complement(1852795..1853283) 1 NC_002935.2 Similar to Mycobacterium tuberculosis single-strand binding protein Ssb SW:SSB_MYCTU (P71711) (164 aa) fasta scores: E(): 0.00073, 29.11% id in 158 aa, and to Mycobacterium smegmatis single-stranded DNA-binding protein TR:Q9AFI5 (EMBL:AF349434) (165 aa) fasta scores: E(): 0.00024, 27.95% id in 161 aa; single-strand binding protein 1853283 2649431 DIP1804 Corynebacterium diphtheriae NCTC 13129 single-strand binding protein NP_940142.1 1852795 R 257309 CDS NP_940143.1 38234376 2649432 complement(1853467..1855503) 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical protein ML1998 SW:Y102_MYCLE (P53525) (659 aa) fasta scores: E(): 2e-44, 31.72% id in 665 aa, and to Mycobacterium tuberculosis hypothetical protein Rv0102 SW:Y102_MYCTU (Q10897) (661 aa) fasta scores: E(): 2.2e-44, 30.76% id in 650 aa; hypothetical protein 1855503 2649432 DIP1805 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940143.1 1853467 R 257309 CDS NP_940144.1 38234377 2649433 1855730..1858015 1 NC_002935.2 Similar to Escherichia coli carbon starvation protein A CstA SW:CSTA_ECOLI (P15078) (701 aa) fasta scores: E(): 2.3e-129, 53.01% id in 696 aa, and to Mycobacterium tuberculosis carbon starvation protein A homologue Rv3063 SW:CSTA_MYCTU (P95095) (758 aa) fasta scores: E(): 5.9e-175, 61.47% id in 719 aa. CDS contains an extended N-terminus in comparison to the E. coli orthologue; carbon starvation protein 1858015 cstA1 2649433 cstA1 Corynebacterium diphtheriae NCTC 13129 carbon starvation protein NP_940144.1 1855730 D 257309 CDS NP_940145.1 38234378 2649434 1858036..1858236 1 NC_002935.2 Similar to Pseudomonas aeruginosa hypothetical protein PA4605 TR:Q9HVI4 (EMBL:AE004874) (67 aa) fasta scores: E(): 0.032, 29.57% id in 71 aa, and to Campylobacter jejuni hypothetical protein Cj0916c TR:Q9PP17 (EMBL:AL139076) (65 aa) fasta scores: E(): 0.052, 34.61% id in 52 aa; hypothetical protein 1858236 2649434 DIP1807 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940145.1 1858036 D 257309 CDS NP_940146.1 38234379 2649435 1858313..1858795 1 NC_002935.2 Similar to Streptococcus pneumoniae hypothetical 20.7 kDa protein TR:Q9KK22 (EMBL:AF154034) (171 aa) fasta scores: E(): 1.3e-08, 33.75% id in 157 aa and to Yersinia pestis insertion element IS1661 DNA-binding protein YPO3492 TR:CAC92721 (EMBL:AJ414157) (171 aa) fasta scores: E(): 0.00044, 25.45% id in 165 aa. Identical to DIP0435, DIP1518, DIP1525 and DIP2124; insertion element DNA-binding protein 1858795 2649435 DIP1808 Corynebacterium diphtheriae NCTC 13129 insertion element DNA-binding protein NP_940146.1 1858313 D 257309 CDS NP_940147.1 38234380 2649436 1858843..1859655 1 NC_002935.2 Similar to Escherichia coli transposase InsK for insertion sequence element IS150 or B3558 SW:INSK_ECOLI (P19769) (283 aa) fasta scores: E(): 2.5e-43, 44.86% id in 263 aa. Identical to DIP0434, DIP1517, DIP1526 and DIP2123; transposase 1859655 2649436 DIP1809 Corynebacterium diphtheriae NCTC 13129 transposase NP_940147.1 1858843 D 257309 CDS NP_940148.1 38234381 2649437 complement(1859708..1860913) 1 NC_002935.2 Similar to Streptomyces spectabilis export protein SpcT TR:Q9L629 (EMBL:AF244574) (432 aa) fasta scores: E(): 3.1e-05, 28.46% id in 411 aa, and to Mycobacterium tuberculosis membrane protein Rv0246 TR:O53668 (EMBL:AL021929) (436 aa) fasta scores: E(): 5.4e-06, 20.94% id in 401 aa; hypothetical protein 1860913 2649437 DIP1810 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940148.1 1859708 R 257309 CDS NP_940149.1 38234382 2649439 1861303..1862349 1 NC_002935.2 Similar to Rhizobium loti dehydrogenase; zinc-binding alcohol dehydrogenase; NADPH quinone oxidoreductase; oxidoreductase MLR3212 TR:Q98GR0 (EMBL:AP003001) (329 aa) fasta scores: E(): 4.7e-52, 47.67% id in 323 aa, and to Pseudomonas aeruginosa probable oxidoreductase PA1833 TR:Q9I2R2 (EMBL:AE004609) (330 aa) fasta scores: E(): 5.9e-45, 43.82% id in 324 aa; zinc-binding dehydrogenase 1862349 2649439 DIP1811 Corynebacterium diphtheriae NCTC 13129 zinc-binding dehydrogenase NP_940149.1 1861303 D 257309 CDS NP_940150.1 38234383 2649440 1862409..1863209 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical protein Rv2509 TR:O06172 (EMBL:Z95556) (268 aa) fasta scores: E(): 1.3e-46, 52.25% id in 266 aa, and to Mycobacterium leprae dehydrogenase MLCl383.36c TR:O07709 (EMBL:Z97179) (268 aa) fasta scores: E(): 1.8e-44, 50.56% id in 265 aa; short chain dehydrogenase 1863209 2649440 DIP1812 Corynebacterium diphtheriae NCTC 13129 short chain dehydrogenase NP_940150.1 1862409 D 257309 CDS NP_940151.1 38234384 2649441 1863228..1863860 1 NC_002935.2 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 1863860 orn 2649441 orn Corynebacterium diphtheriae NCTC 13129 oligoribonuclease NP_940151.1 1863228 D 257309 CDS NP_940152.1 38234385 2649443 1864038..1864868 1 NC_002935.2 Similar to Corynebacterium glutamicum dihydrodipicolinate synthase DapA SW:DAPA_CORGL (P19808) (301 aa) fasta scores: E(): 7.7e-14, 29.25% id in 270 aa, and to Streptomyces coelicolor dihydrodipicolinate synthase SC9A10.08 SW:DAPA_STRCO (O86841) (299 aa) fasta scores: E(): 2.5e-13, 27.94% id in 272 aa; dihydrodipicolinate synthase 1864868 2649443 DIP1814 Corynebacterium diphtheriae NCTC 13129 dihydrodipicolinate synthase NP_940152.1 1864038 D 257309 CDS NP_940153.1 38234386 2649444 complement(1864869..1866038) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical protein Rv2518c TR:O53223 (EMBL:AL021185) (408 aa) fasta scores: E(): 6.9e-67, 53.02% id in 347 aa, and to Mycobacterium leprae secreted protein ML0426 TR:Q9CCU5 (EMBL:AL583918) (404 aa) fasta scores: E(): 5.2e-63, 49.28% id in 349 aa; lipoprotein 1866038 2649444 DIP1815 Corynebacterium diphtheriae NCTC 13129 lipoprotein NP_940153.1 1864869 R 257309 CDS NP_940154.1 38234387 2649445 complement(1866129..1866317) 1 NC_002935.2 hypothetical protein 1866317 2649445 DIP1816 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940154.1 1866129 R 257309 CDS NP_940155.1 38234388 2649447 1866723..1866953 1 NC_002935.2 Weakly similar to Bacillus halodurans hypothetical protein Bh3463 TR:Q9K7A5 (EMBL:AP001518) (79 aa) fasta scores: E(): 2.9, 27.778% id in 72 aa; hypothetical protein 1866953 2649447 DIP1817 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940155.1 1866723 D 257309 CDS NP_940156.1 38234389 2649448 1866950..1867234 1 NC_002935.2 hypothetical protein 1867234 2649448 DIP1818 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940156.1 1866950 D 257309 CDS NP_940157.1 38234390 2649449 1867227..1867556 1 NC_002935.2 hypothetical protein 1867556 2649449 DIP1819 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940157.1 1867227 D 257309 CDS NP_940158.1 38234391 2649450 1867754..1867873 1 NC_002935.2 hypothetical protein 1867873 2649450 DIP1820 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940158.1 1867754 D 257309 CDS NP_940159.1 38234392 2649451 1867939..1868061 1 NC_002935.2 Questionable CDS; no significant database matches; hypothetical protein 1868061 2649451 DIP1821 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940159.1 1867939 D 257309 CDS NP_940160.1 38234393 2649452 1868441..1868842 1 NC_002935.2 hypothetical protein 1868842 2649452 DIP1822 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940160.1 1868441 D 257309 CDS NP_940161.1 38234394 2649453 1868835..1869113 1 NC_002935.2 Similar to bacteriophage phi-C31 hypothetical protein orf 7 TR:Q38028 (EMBL:X76288) (121 aa) fasta scores: E(): 0.0011, 40.385% id in 52 aa, and to Deinococcus radiodurans conserved hypothetical protein DR2409 TR:Q9RRS6 (EMBL:AE002071) (186 aa) fasta scores: E(): 0.0026, 39.683% id in 63 aa, and to Mycobacterium tuberculosis CDC1551 HNH endonuclease MT2545 TR:AAK46845 (EMBL:AE007091) (222 aa) fasta scores: E(): 0.049, 36.986% id in 73 aa; HNH endonuclease 1869113 2649453 DIP1823 Corynebacterium diphtheriae NCTC 13129 HNH endonuclease NP_940161.1 1868835 D 257309 CDS NP_940162.1 38234395 2649454 1869496..1870953 1 NC_002935.2 Similar to Mycobacteriophage TM4 terminase gp4 TR:Q9ZX73 (EMBL:AF068845) (474 aa) fasta scores: E(): 2.6e-13, 24.364% id in 472 aa, and to Bacteriophage HK97 terminase large subunit 2 TR:Q9MCT1 (EMBL:AF069529) (504 aa) fasta scores: E(): 0.019, 23.741% id in 278 aa; phage terminase 1870953 2649454 DIP1824 Corynebacterium diphtheriae NCTC 13129 phage terminase NP_940162.1 1869496 D 257309 CDS NP_940163.1 38234396 2649455 1871192..1872241 1 NC_002935.2 hypothetical protein 1872241 2649455 DIP1825 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940163.1 1871192 D 257309 CDS NP_940164.1 38234397 2649456 1872225..1872776 1 NC_002935.2 Some similarity to Clostridium perfringens plasmid pCP13 hypothetical 28.2 kDa protein pcp29 TR:BAB62467 (EMBL:AP003515) (252 aa) fasta scores: E(): 1.4e-05, 27.513% id in 189 aa; hypothetical protein 1872776 2649456 DIP1826 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940164.1 1872225 D 257309 CDS NP_940165.1 38234398 2649457 complement(1872831..1873118) 1 NC_002935.2 hypothetical protein 1873118 2649457 DIP1827 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940165.1 1872831 R 257309 CDS NP_940166.1 38234399 2649458 1873196..1874599 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 18.5 kDa protein Rv1577c or MTCY336.27 TR:O06613 (EMBL:Z95586) (170 aa) fasta scores: E(): 4.4e-06, 34.507% id in 142 aa, and to Mycobacterium tuberculosis hypothetical 19.3 kDa protein Rv2651c or MTCY441.20c TR:P71948 (EMBL:Z80225) (177 aa) fasta scores: E(): 4.5e-06, 35.664% id in 143 aa; hypothetical protein 1874599 2649458 DIP1828 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940166.1 1873196 D 257309 CDS NP_940167.1 38234400 2649459 1874599..1874910 1 NC_002935.2 hypothetical protein 1874910 2649459 DIP1829 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940167.1 1874599 D 257309 CDS NP_940168.1 38234401 2649205 1874955..1875281 1 NC_002935.2 hypothetical protein 1875281 2649205 DIP1830 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940168.1 1874955 D 257309 CDS NP_940169.1 38234402 2649206 1875281..1875703 1 NC_002935.2 Similar to Bifidobacterium longum NCC2705 hypothetical protein BL0379 SWALL:AAN24215 (EMBL:AE014655) (140 aa) fasta scores: E(): 1.7e-05, 34.14% id in 123 aa; hypothetical protein 1875703 2649206 DIP1831 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940169.1 1875281 D 257309 CDS NP_940170.1 38234403 2649207 1875706..1876119 1 NC_002935.2 Similar to Bacteriophage phi-C31 gp40 40 TR:Q9ZXA7 (EMBL:AJ006589) (143 aa) fasta scores: E(): 1.3e-05, 25.362% id in 138 aa; hypothetical protein 1876119 2649207 DIP1832 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940170.1 1875706 D 257309 CDS NP_940171.1 38234404 2649208 1876119..1876430 1 NC_002935.2 Similar to Bacteriophage Mu hypothetical protein gp14 14 or e15 SW:VG14_BPMU (Q38492) (100 aa) fasta scores: E(): 0.86, 32.955% id in 88 aa; hypothetical protein 1876430 2649208 DIP1833 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940171.1 1876119 D 257309 CDS NP_940172.1 38234405 2649209 1876508..1878073 1 NC_002935.2 Similar to Bacteriophage r1t ORF40 TR:Q38126 (EMBL:U38906) (213 aa) fasta scores: E(): 0.019, 25.904% id in 166 aa, and to Escherichia coli O157:H7 tail length tape measure protein precursor ECS2949 TR:BAB36372 (EMBL:AP002560) (881 aa) fasta scores: E(): 0.025, 27.698% id in 278 aa; hypothetical protein 1878073 2649209 DIP1834 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940172.1 1876508 D 257309 CDS NP_940173.1 38234406 2649210 1878067..1879254 1 NC_002935.2 hypothetical protein 1879254 2649210 DIP1835 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940173.1 1878067 D 257309 CDS NP_940174.1 38234407 2649211 1879255..1880043 1 NC_002935.2 Contains collagen-like Pro/Gly repeat; Similar to Gallus gallus collagen alpha 1 Col3A1 SW:CA13_CHICK (P12105) (1262 aa) fasta scores: E(): 3.8e-13, 48.023% id in 177 aa; triple helix repeat-containing collagen 1880043 2649211 DIP1836 Corynebacterium diphtheriae NCTC 13129 triple helix repeat-containing collagen NP_940174.1 1879255 D 257309 CDS NP_940175.1 38234408 2649212 complement(1880040..1880855) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 phage integrase MT2724 TR:AAK47038 (EMBL:AE007103) (332 aa) fasta scores: E(): 1.9e-29, 39.615% id in 260 aa, and to Bacillus subtilis probable integrase/recombinase RipX ripX SW:RIPX_BACSU (P46352) (296 aa) fasta scores: E(): 0.00033, 30.435% id in 230 aa; phage integrase 1880855 2649212 DIP1837 Corynebacterium diphtheriae NCTC 13129 phage integrase NP_940175.1 1880040 R 257309 CDS NP_940176.1 38234409 2649213 complement(1881329..1881508) 1 NC_002935.2 hypothetical protein 1881508 2649213 DIP1838 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940176.1 1881329 R 257309 CDS NP_940177.1 38234410 2649214 1881693..1882151 1 NC_002935.2 Poor database matches. C-terminus is similar to the C-terminal regions of Streptomyces coelicolor nicotinamidase SCE19A.18 TR:Q9S2G3 (EMBL:AL096852) (195 aa) fasta scores: E(): 6.4e-06, 33.33% id in 105 aa, and Mycobacterium avium pyrazinamidase/nicotinamidase PncA TR:P94914 (EMBL:U80820) (187 aa) fasta scores: E(): 2.8e-05, 36% id in 125 aa; hypothetical protein 1882151 2649214 DIP1840 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940177.1 1881693 D 257309 CDS NP_940178.1 38234411 2649215 complement(1882155..1882460) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical protein Rv3592 TR:O06156 (EMBL:Z95555) (105 aa) fasta scores: E(): 1.5e-21, 58.16% id in 98 aa, and to Mycobacterium leprae hypothetical protein ML1922 TR:Q9CBI8 (EMBL:AL583923) (105 aa) fasta scores: E(): 5.5e-19, 53.46% id in 101 aa; hypothetical protein 1882460 2649215 DIP1841 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940178.1 1882155 R 257309 CDS NP_940179.1 38234412 2649216 complement(1882473..1882748) 1 NC_002935.2 Poor database matches. Similar to Mycobacterium tuberculosis hypothetical protein Rv2520c TR:O53225 (EMBL:AL021185) (75 aa) fasta scores: E(): 2.7e-06, 45.33% id in 75 aa; hypothetical protein 1882748 2649216 DIP1842 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940179.1 1882473 R 257309 CDS NP_940180.1 38234413 2649217 1882837..1883310 1 NC_002935.2 Similar to Escherichia coli bacterioferritin comigratory protein Bcp SW:BCP_ECOLI (P23480) (156 aa) fasta scores: E(): 7e-23, 46.8% id in 141 aa, and to Mycobacterium tuberculosis bacterioferritin comigratory protein Rv2521 TR:O53226 (EMBL:AL021185) (157 aa) fasta scores: E(): 3.5e-37, 62.17% id in 156 aa; bacterioferritin comigratory protein 1883310 bcp 2649217 bcp Corynebacterium diphtheriae NCTC 13129 bacterioferritin comigratory protein NP_940180.1 1882837 D 257309 CDS NP_940181.1 38234414 2649218 1883311..1883955 1 NC_002935.2 Similar to Rhizobium loti transcriptional regulator MLL3939 TR:Q98F48 (EMBL:AP003003) (209 aa) fasta scores: E(): 4.6e-12, 33.65% id in 208 aa, and to Pseudomonas aeruginosa probable transcriptional regulator PA1403 TR:Q9I3U1 (EMBL:AE004569) (210 aa) fasta scores: E(): 2e-05, 27.57% id in 214 aa; TetR family regulatory protein 1883955 2649218 DIP1844 Corynebacterium diphtheriae NCTC 13129 TetR family regulatory protein NP_940181.1 1883311 D 257309 CDS NP_940182.1 38234415 2649219 complement(1883952..1884335) 1 NC_002935.2 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 1884335 acpS 2649219 acpS Corynebacterium diphtheriae NCTC 13129 4'-phosphopantetheinyl transferase NP_940182.1 1883952 R 257309 CDS NP_940183.1 38234416 2649220 complement(1884370..1893303) 1 NC_002935.2 Similar to the N-terminal region of Corynebacterium ammoniagenes fatty acid synthase Fas TR:Q04846 (EMBL:X64795) (3104 aa) fasta scores: E(): 0, 61.33% id in 3018 aa, and to the full length of Mycobacterium tuberculosis fatty acid synthase Rv2524c TR:AAK46907 (EMBL:Z83863) (3069 aa) fasta scores: E(): 1e-197, 51.37% id in 3083 aa, and of Corynebacterium glutamicum 3-oxoacyl-(acyl-carrier-protein) synthase CGL2495 SWALL:Q8NMS0 (EMBL:AP005281) (2993 aa) fasta scores: E(): 0, 67.35% id in 3008 aa; fatty acid synthase 1893303 fas 2649220 fas Corynebacterium diphtheriae NCTC 13129 fatty acid synthase NP_940183.1 1884370 R 257309 CDS NP_940184.1 38234417 2649221 complement(1893482..1893859) 1 NC_002935.2 hypothetical protein 1893859 2649221 DIP1847 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940184.1 1893482 R 257309 CDS NP_940185.1 38234418 2649223 1894158..1894535 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical protein Rv1343c SW:YD43_MYCTU (Q11013) (126 aa) fasta scores: E(): 6.9e-12, 47.61% id in 84 aa, and to Mycobacterium leprae hypothetical protein ML1177 SW:YD43_MYCLE (P54134) (126 aa) fasta scores: E(): 1.5e-11, 46.42% id in 84 aa; hypothetical protein 1894535 2649223 DIP1848 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940185.1 1894158 D 257309 CDS NP_940186.1 38234419 2649224 1894563..1894919 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical protein ML1176 (P54133) (119 aa) fasta scores: E(): 3.7e-09, 39.28% id in 112 aa, and to Mycobacterium tuberculosis hypothetical protein Rv1342c SW:YD42_MYCTU (Q11012) (120 aa) fasta scores: E(): 1.5e-08, 37.16% id in 113 aa; hypothetical protein 1894919 2649224 DIP1849 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940186.1 1894563 D 257309 CDS NP_940187.1 38234420 2649225 complement(1894916..1895539) 1 NC_002935.2 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 1895539 2649225 DIP1850 Corynebacterium diphtheriae NCTC 13129 deoxyribonucleotide triphosphate pyrophosphatase NP_940187.1 1894916 R 257309 CDS NP_940188.1 38234421 2649226 complement(1895536..1896261) 1 NC_002935.2 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 1896261 rph 2649226 rph Corynebacterium diphtheriae NCTC 13129 ribonuclease PH NP_940188.1 1895536 R 257309 CDS NP_940189.1 38234422 2649227 complement(1896272..1897090) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical protein Rv1339 SW:YD39_MYCTU (Q10648) (273 aa) fasta scores: E(): 5.5e-46, 46.18% id in 249 aa, and to Mycobacterium leprae hypothetical protein ML1173 SW:YD39_MYCLE (P50474) (284 aa) fasta scores: E(): 6.6e-46, 46.18% id in 249 aa; hypothetical protein 1897090 2649227 DIP1852 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940189.1 1896272 R 257309 CDS NP_940190.1 38234423 2649228 complement(1897092..1897889) 1 NC_002935.2 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1897889 murI 2649228 murI Corynebacterium diphtheriae NCTC 13129 glutamate racemase NP_940190.1 1897092 R 257309 CDS NP_940191.1 38234424 2649229 complement(1897886..1898458) 1 NC_002935.2 Similar to Synechocystis sp. hypothetical protein SLR1461 TR:P74553 (EMBL:D90916) (198 aa) fasta scores: E(): 3e-21, 38.95% id in 172 aa, and to Bacillus halodurans hypothetical protein BH0517 TR:Q9KFG2 (EMBL:AP001508) (248 aa) fasta scores: E(): 3.1e-05, 29.1% id in 189 aa; hypothetical protein 1898458 2649229 DIP1854 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940191.1 1897886 R 257309 CDS NP_940192.1 38234425 2649230 complement(1898455..1899387) 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical protein ML1167 SW:YD33_MYCLE (P53425) (362 aa) fasta scores: E(): 4.2e-24, 48.07% id in 337 aa, and to Streptomyces coelicolor hypothetical protein SCE22.10 TR:Q9KYV2 (EMBL:AL355832) (348 aa) fasta scores: E(): 4.6e-24, 47.38% id in 325 aa; hypothetical protein 1899387 2649230 DIP1855 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940192.1 1898455 R 257309 CDS NP_940193.1 38234426 2649231 complement(1899387..1899923) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical protein Rv1332 SW:YD32_MYCTU (Q10643) (218 aa) fasta scores: E(): 1.3e-10, 35.53% id in 197 aa, and to Mycobacterium leprae hypothetical protein ML1166 SW:YD32_MYCLE (P53424) (217 aa) fasta scores: E(): 2.1e-08, 33.5% id in 200 aa. CDS is contains fewer residues at the N-terminus in comparison to the Mycobacterium proteins; hypothetical protein 1899923 2649231 DIP1856 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940193.1 1899387 R 257309 CDS NP_940194.1 38234427 2649232 complement(1899940..1900281) 1 NC_002935.2 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 1900281 clpS 2649232 clpS Corynebacterium diphtheriae NCTC 13129 ATP-dependent Clp protease adaptor protein ClpS NP_940194.1 1899940 R 257309 CDS NP_940195.1 38234428 2649233 1900343..1901656 1 NC_002935.2 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1901656 2649233 DIP1858 Corynebacterium diphtheriae NCTC 13129 nicotinate phosphoribosyltransferase NP_940195.1 1900343 D 257309 CDS NP_940196.1 38234429 2649234 1901706..1903655 1 NC_002935.2 Similar to Escherichia coli probable ATP-dependent helicase DinG SW:DING_ECOLI (P27296) (716 aa) fasta scores: E(): 5.6e-15, 27.57% id in 689 aa, and to Mycobacterium tuberculosis probable ATP-dependent helicase DinG homologue Rv1329c SW:DING_MYCTU (Q10640) (664 aa) fasta scores: E(): 2.2e-131, 55.84% id in 659 aa; DeaD/DeaH family helicase 1903655 2649234 DIP1859 Corynebacterium diphtheriae NCTC 13129 DeaD/DeaH family helicase NP_940196.1 1901706 D 257309 CDS NP_940197.1 38234430 2649235 1903657..1904184 1 NC_002935.2 Similar to Streptomyces coelicolor acetyltransferase SCC46.14 TR:Q9L1I8 (EMBL:AL139164) (202 aa) fasta scores: E(): 1.3e-08, 28.09% id in 178 aa, and to Deinococcus radiodurans acetyltransferase DR1800 TR:Q9RTG4 (EMBL:AE002021) (179 aa) fasta scores: E(): 8.9e-08, 29.76% id in 168 aa; acetyltransferase (GNAT) family protein 1904184 2649235 DIP1860 Corynebacterium diphtheriae NCTC 13129 acetyltransferase (GNAT) family protein NP_940197.1 1903657 D 257309 CDS NP_940198.1 38234431 2649236 1904274..1905374 1 NC_002935.2 No significant database matches to the full length CDS. C-terminus is similar to an internal region of Mycobacterium tuberculosis hypothetical protein Rv2100 SW:YL00_MYCTU (Q10709) (550 aa) fasta scores: E(): 9.8e-09, 35.15% id in 128 aa; hypothetical protein 1905374 2649236 DIP1861 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940198.1 1904274 D 257309 CDS NP_940199.1 38234432 2649237 complement(1905358..1906065) 1 NC_002935.2 Poor database matches. Similar to Streptomyces coelicolor hypothetical protein SC1B5.06c TR:O69834 (EMBL:AL023517) (249 aa) fasta scores: E(): 9e-23, 41.42% id in 210 aa. C-terminal region is similar to Pyrococcus horikoshii hypothetical protein PH1539 SW:YF39_PYRHO (O74017) (121 aa) fasta scores: E(): 0.0025, 36.84% id in 95 aa; hypothetical protein 1906065 2649237 DIP1862 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940199.1 1905358 R 257309 CDS NP_940200.1 38234433 2649238 complement(1906058..1907290) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical protein Rv3042c TR:AAK47457 (EMBL:AL021287) (409 aa) fasta scores: E(): 3.1e-69, 54.54% id in 407 aa, and to Mycobacterium leprae phosphoserine phosphatase ML1727 TR:Q9CBQ6 (EMBL:AL583923) (411 aa) fasta scores: E(): 6.2e-66, 53.82% id in 405 aa; hydrolase 1907290 2649238 DIP1863 Corynebacterium diphtheriae NCTC 13129 hydrolase NP_940200.1 1906058 R 257309 CDS NP_940201.1 38234434 2649239 complement(1907448..1909142) 1 NC_002935.2 Similar to Bacillus firmus cytochrome C oxidase subunit I CtaD SW:COX1_BACFI (Q04440) (624 aa) fasta scores: E(): 9.5e-98, 48.56% id in 523 aa, and to Corynebacterium glutamicum cytochrome AA3 oxidase subunit I CtaD TR:Q9AEL9 (EMBL:AJ306417) (584 aa) fasta scores: E(): 1.2e-200, 84.39% id in 564 aa; cytochrome C oxidase polypeptide I 1909142 ctaD 2649239 ctaD Corynebacterium diphtheriae NCTC 13129 cytochrome C oxidase polypeptide I NP_940201.1 1907448 R 257309 CDS NP_940202.1 38234435 2649240 complement(1909504..1910490) 1 NC_002935.2 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1910490 nrdF 2649240 nrdF Corynebacterium diphtheriae NCTC 13129 ribonucleotide-diphosphate reductase subunit beta NP_940202.1 1909504 R 257309 CDS NP_940203.1 38234436 2649241 1910803..1911288 1 NC_002935.2 Similar to Escherichia coli ferritin 1 FtnA SW:FTNA_ECOLI (P23887) (165 aa) fasta scores: E(): 5.9e-10, 29.29% id in 157 aa, and to Methanothermobacter thermautotrophicus ferritin like protein MTH158 TR:O26261 (EMBL:AE000804) (171 aa) fasta scores: E(): 2.6e-17, 36.25% id in 160 aa; bacterioferritin 1911288 2649241 DIP1866 Corynebacterium diphtheriae NCTC 13129 bacterioferritin NP_940203.1 1910803 D 257309 CDS NP_940204.1 38234437 2649242 complement(1911340..1913499) 1 NC_002935.2 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1913499 nrdE 2649242 nrdE Corynebacterium diphtheriae NCTC 13129 ribonucleotide-diphosphate reductase subunit alpha NP_940204.1 1911340 R 257309 CDS NP_940205.1 38234438 2649243 complement(1913549..1913974) 1 NC_002935.2 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 1913974 nrdI 2649243 nrdI Corynebacterium diphtheriae NCTC 13129 ribonucleotide reductase stimulatory protein NP_940205.1 1913549 R 257309 CDS NP_940206.1 38234439 2649244 complement(1914068..1914301) 1 NC_002935.2 Similar to Escherichia coli glutaredoxin-like protein NrdH SW:NRDH_ECOLI (Q47414) (81 aa) fasta scores: E(): 4.5e-09, 41.66% id in 72 aa, and to Corynebacterium ammoniagenes NrdH-redoxin TR:O69271 (EMBL:Y09572) (75 aa) fasta scores: E(): 4.4e-23, 81.08% id in 74 aa; hypothetical protein 1914301 2649244 DIP1869 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940206.1 1914068 R 257309 CDS NP_940207.1 38234440 2649245 1914603..1915475 1 NC_002935.2 Similar to Agrobacterium aurantiacum phytoene synthase CrtB SW:CRTB_AGRAU (P54975) (301 aa) fasta scores: E(): 6.8e-09, 29.57% id in 284 aa, and to Corynebacterium glutamicum phytoene synthase CrtB TR:AAK64298 (EMBL:AF159510) (304 aa) fasta scores: E(): 1.1e-51, 51.22% id in 285 aa; phytoene synthase 1915475 2649245 DIP1870 Corynebacterium diphtheriae NCTC 13129 phytoene synthase NP_940207.1 1914603 D 257309 CDS NP_940208.1 38234441 2649246 1915468..1916994 1 NC_002935.2 Similar to Neurospora crassa phytoene dehydrogenase Al-1 SW:CRTI_NEUCR (P21334) (595 aa) fasta scores: E(): 1.6e-33, 29.77% id in 524 aa, and to Corynebacterium glutamicum phytoene desaturase CrtI TR:AAK64299 (EMBL:AF159510) (549 aa) fasta scores: E(): 5.6e-107, 54.59% id in 511 aa; phytoene dehydrogenase related enzyme 1916994 2649246 DIP1871 Corynebacterium diphtheriae NCTC 13129 phytoene dehydrogenase related enzyme NP_940208.1 1915468 D 257309 CDS NP_940209.1 38234442 2649247 complement(1917063..1917185) 1 NC_002935.2 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; 50S ribosomal protein L36 1917185 rpmJ 2649247 rpmJ Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L36 NP_940209.1 1917063 R 257309 CDS NP_940210.1 38234443 2649248 1917354..1918172 1 NC_002935.2 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1918172 nadE 2649248 nadE Corynebacterium diphtheriae NCTC 13129 NAD synthetase NP_940210.1 1917354 D 257309 CDS NP_940211.1 38234444 2649249 complement(1918169..1918606) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical protein SCJ12.09c TR:Q9RI49 (EMBL:AL109989) (146 aa) fasta scores: E(): 7.2e-10, 38.68% id in 137 aa. C-terminal region is similar to Mycobacterium tuberculosis hypothetical protein Rv3129 TR:O05803 (EMBL:Z95150) (110 aa) fasta scores: E(): 5.1e-11, 47.77% id in 90 aa; hypothetical protein 1918606 2649249 DIP1874 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940211.1 1918169 R 257309 CDS NP_940212.1 38234445 2649250 complement(1918653..1918961) 1 NC_002935.2 Poor database matches. C-terminal region is similar to Clostridium acetobutylicum hypothetical protein CAC0072 TR:AAK78058 (EMBL:AE007520) (77 aa) fasta scores: E(): 0.01, 29.16% id in 72 aa; hypothetical protein 1918961 2649250 DIP1875 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940212.1 1918653 R 257309 CDS NP_940213.1 38234446 2649251 complement(1918965..1920353) 1 NC_002935.2 C-terminus is similar to an internal regions of Neisseria gonorrhoeae major anaerobically induced outer membrane protein Pan 1 AniA SW:ANIA_NEIGO (Q02219) (392 aa) fasta scores: E(): 3.5e-18, 30.1% id in 299 aa, and Neisseria meningitidis nitrite reductase, major outer membrane copper-containing protein NMA1887 TR:Q9JTB8 (EMBL:AL162757) (386 aa) fasta scores: E(): 3e-18, 30.43% id in 299 aa; multicopper oxidase 1920353 2649251 DIP1876 Corynebacterium diphtheriae NCTC 13129 multicopper oxidase NP_940213.1 1918965 R 257309 CDS NP_940214.1 38234447 2649252 complement(1920343..1921635) 1 NC_002935.2 No significant database matches to the full length CDS. C-terminus is similar to the N-terminal regions of Rhizobium meliloti hypothetical protein SMA0447 TR:AAK64892 (EMBL:AE007216) (373 aa) fasta scores: E(): 0.48, 22.94% id in 353 aa; hypothetical protein 1921635 2649252 DIP1877 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940214.1 1920343 R 257309 CDS NP_940215.1 38234448 2649253 complement(1921639..1922748) 1 NC_002935.2 Poor database matches. C-terminal region is weakly similar to Sulfolobus solfataricus hypothetical protein Sso2014 sso2014 TR:Q97WV0 (EMBL:AE006808) (307 aa) fasta scores: E(): 0.44, 21.34% id in 328 aa; hypothetical protein 1922748 2649253 DIP1878 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940215.1 1921639 R 257309 CDS NP_940216.1 38234449 2649254 1922840..1923505 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical protein Rv2621c TR:O06191 (EMBL:Z95387) (224 aa) fasta scores: E(): 2.3e-05, 27.12% id in 188 aa, and to Deinococcus radiodurans conserved hypothetical protein DR0999 TR:Q9RvM8 (EMBL:AE001952) (225 aa) fasta scores: E(): 0.01, 23.62% id in 182 aa; DNA-binding protein 1923505 2649254 DIP1879 Corynebacterium diphtheriae NCTC 13129 DNA-binding protein NP_940216.1 1922840 D 257309 CDS NP_940217.1 38234450 2649256 complement(1923706..1924440) 1 NC_002935.2 Poor database matches. Weakly similar to Streptomyces coelicolor hypothetical protein SC4G6.36 TR:Q9S2S3 (EMBL:AL096884) (266 aa) fasta scores: E(): 4.7e-06, 26.22% id in 225 aa, and to Mycobacterium leprae possible conserved membrane protein ML1667 TR:Q9CBS4 (EMBL:AL583923) (264 aa) fasta scores: E(): 1.5e-05, 28.77% id in 212 aa; hypothetical protein 1924440 2649256 DIP1880 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940217.1 1923706 R 257309 CDS NP_940218.1 38234451 2649257 complement(1924490..1924942) 1 NC_002935.2 Poor database matches. Similar to the N-terminal regions of Paracoccus denitrificans methylamine utilization protein MauE SW:MAUE_PARDE (P29896) (186 aa) fasta scores: E(): 0.00023, 30.89% id in 123 aa, and Methylobacterium extorquens methylamine utilization protein MauE SW:MAUE_METEX (Q49125) (187 aa) fasta scores: E(): 0.026, 29% id in 100 aa; hypothetical protein 1924942 2649257 DIP1881 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940218.1 1924490 R 257309 CDS NP_940219.1 38234452 2649258 complement(1924981..1926618) 1 NC_002935.2 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 1926618 pgm 2649258 pgm Corynebacterium diphtheriae NCTC 13129 phosphoglucomutase NP_940219.1 1924981 R 257309 CDS NP_940220.1 38234453 2649259 1926684..1926971 1 NC_002935.2 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1926971 ccrB 2649259 ccrB Corynebacterium diphtheriae NCTC 13129 camphor resistance protein CrcB NP_940220.1 1926684 D 257309 CDS NP_940221.1 38234454 2649260 1926968..1927282 1 NC_002935.2 Similar to Streptococcus pneumoniae CrcB protein SP1294 TR:AAK75398 (EMBL:AE007428) (109 aa) fasta scores: E(): 7.4e-06, 33.33% id in 108 aa, and to Bacillus subtilis protein CrcB homolog 1 CrcB1 TR:O07590 (EMBL:Y14082) (118 aa) fasta scores: E(): 0.033, 29.56% id in 115 aa; hypothetical protein 1927282 2649260 DIP1884 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940221.1 1926968 D 257309 CDS NP_940222.1 38234455 2649261 complement(1927279..1929843) 1 NC_002935.2 Similar to Streptomyces coelicolor ABC transport system integral membrane protein SCE41.19c TR:Q9F2P0 (EMBL:AL442120) (854 aa) fasta scores: E(): 6.5e-62, 30.8% id in 870 aa, and to Streptomyces coelicolor ABC transporter integral membrane protein SCE25.31 TR:Q9KZ59 (EMBL:AL354048) (843 aa) fasta scores: E(): 2.6e-41, 33.83% id in 857 aa; ABC transporter permease 1929843 2649261 DIP1885 Corynebacterium diphtheriae NCTC 13129 ABC transporter permease NP_940222.1 1927279 R 257309 CDS NP_940223.1 38234456 2649262 complement(1929844..1930593) 1 NC_002935.2 Similar to Streptomyces coelicolor ABC transport system ATP-binding protein SCE41.20c TR:Q9F2N9 (EMBL:AL442120) (262 aa) fasta scores: E(): 9.4e-54, 63.9% id in 241 aa, and to Streptomyces coelicolor ABC transporter ATP-binding protein SCE25.30 TR:Q9KZ60 (EMBL:AL354048) (256 aa) fasta scores: E(): 4.6e-53, 67.37% id in 236 aa; ABC transporter ATP-binding protein 1930593 2649262 DIP1886 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_940223.1 1929844 R 257309 CDS NP_940224.1 38234457 2649266 complement(1937107..1938363) 1 NC_002935.2 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1938363 murA 2649266 murA Corynebacterium diphtheriae NCTC 13129 UDP-N-acetylglucosamine 1-carboxyvinyltransferase NP_940224.1 1937107 R 257309 CDS NP_940225.1 38234458 2649267 1938402..1938977 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical protein Rv1314c SW:YD14_MYCTU (Q10622) (193 aa) fasta scores: E(): 3.1e-50, 70.15% id in 191 aa, and to Mycobacterium leprae hypothetical protein ML1149 SW:YD14_MYCLE (P53523) (191 aa) fasta scores: E(): 1e-47, 65.96% id in 191 aa; hypothetical protein 1938977 2649267 DIP1888 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940225.1 1938402 D 257309 CDS NP_940226.1 38234459 2649268 complement(1939030..1939875) 1 NC_002935.2 Similar to Streptomyces coelicolor transcriptional regulator SC2G5.15C TR:Q9Z5A8 (EMBL:AL035478) (279 aa) fasta scores: E(): 9.5e-35, 44.89% id in 274 aa, and to Rhizobium meliloti transcription regulator protein SMC03015 TR:CAC45219 (EMBL:AL591784) (245 aa) fasta scores: E(): 0.012, 25.55% id in 227 aa; transcriptional regulator 1939875 2649268 DIP1889 Corynebacterium diphtheriae NCTC 13129 transcriptional regulator NP_940226.1 1939030 R 257309 CDS NP_940227.1 38234460 2649269 1940558..1941493 1 NC_002935.2 Similar to the C-terminal region of Arabidopsis thaliana cysteine synthase, mitochondrial precursor ACS 1 SW:CYSM_ARATH (Q43725) (424 aa) fasta scores: E(): 1.5e-58, 53.39% id in 309 aa, and to the full length Neisseria meningitidis (serogroup A) cysteine synthase NMA0974 TR:Q9JQL6 (EMBL:AL162754) (310 aa) fasta scores: E(): 5.6e-65, 59.09% id in 308 aa; cysteine synthase 1941493 2649269 DIP1890 Corynebacterium diphtheriae NCTC 13129 cysteine synthase NP_940227.1 1940558 D 257309 CDS NP_940228.1 38234461 2649270 1941600..1942166 1 NC_002935.2 Similar to Staphylococcus xylosus serine acetyltransferase CysE SW:CYSE_STAXY (P77985) (216 aa) fasta scores: E(): 9.3e-33, 55.68% id in 167 aa, and to Azotobacter vinelandii O-acetylserine synthase CysE2 TR:O69218 (EMBL:AF010139) (251 aa) fasta scores: E(): 6.1e-38, 58.85% id in 175 aa; serine acetyltransferase 1942166 cysE 2649270 cysE Corynebacterium diphtheriae NCTC 13129 serine acetyltransferase NP_940228.1 1941600 D 257309 CDS NP_940229.1 38234462 2649271 complement(1942208..1942489) 1 NC_002935.2 Similar to Streptomyces coelicolor conserved hypothetical protein SC8D11.21 TR:Q9AJZ8 (EMBL:AL512944) (112 aa) fasta scores: E(): 1.5e-08, 40% id in 85 aa, and to Streptomyces coelicolor conserved hypothetical protein SC8D11.19 TR:Q9AK00 (EMBL:AL512944) (102 aa) fasta scores: E(): 1.9e-05, 32.96% id in 91 aa; hypothetical protein 1942489 2649271 DIP1892 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940229.1 1942208 R 257309 CDS NP_940230.1 38234463 2649273 complement(1942871..1943947) 1 NC_002935.2 Similar to Escherichia coli glycerol dehydrogenase GldA SW:GLDA_ECOLI (P32665) (367 aa) fasta scores: E(): 6.1e-21, 29% id in 331 aa, and to Streptococcus pneumoniae glycerol dehydrogenase SP0253 TR:AAK74432 (EMBL:AE007338) (362 aa) fasta scores: E(): 3e-22, 29.64% id in 361 aa; hypothetical protein 1943947 2649273 DIP1893 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940230.1 1942871 R 257309 CDS NP_940231.1 38234464 2648943 complement(1944430..1947027) 1 NC_002935.2 No significant database matches to the full length CDS. Internal region is weakly similar to an internal region of Thermoplasma volcanium hypothetical protein TVG1552703 TR:BAB60643 (EMBL:AP000996) (974 aa) fasta scores: E(): 5.5e-05, 21.86% id in 773 aa; hypothetical protein 1947027 2648943 DIP1894 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940231.1 1944430 R 257309 CDS NP_940232.1 38234465 2648944 complement(1947027..1948868) 1 NC_002935.2 Internal region is similar to an internal regions of Salmonella typhimurium type III restriction-modification system StyLTI enzyme Mod SW:T3MO_SALTY (P40814) (651 aa) fasta scores: E(): 1.8e-20, 29.39% id in 398 aa, and Xylella fastidiosa methyltransferase XF1968 TR:Q9PC17 (EMBL:AE004016) (534 aa) fasta scores: E(): 5.9e-33, 35.25% id in 417 aa; DNA methylase 1948868 2648944 DIP1895 Corynebacterium diphtheriae NCTC 13129 DNA methylase NP_940232.1 1947027 R 257309 CDS NP_940233.1 38234466 2648945 1949307..1949477 1 NC_002935.2 Similar to the C-terminal regions of Saccharopolyspora sp. transposase SapX TR:O52713 (EMBL:AF045021) (103 aa) fasta scores: E(): 0.00038, 45.83% id in 48 aa, and Streptomyces lividans similar to Orf1 of the IS3 family TR:Q54335 (EMBL:U50076) (103 aa) fasta scores: E(): 0.076, 47.61% id in 42 aa; transposase (partial) 1949477 2648945 DIP1896 Corynebacterium diphtheriae NCTC 13129 transposase (partial) NP_940233.1 1949307 D 257309 CDS NP_940234.1 38234467 2648946 1949524..1949853 1 NC_002935.2 Similar to N-terminal region of Corynebacterium jeikeium transposase B TnpB TR:AAK67710 (EMBL:AY036070) (302 aa) fasta scores: E(): 4.1e-08, 40% id in 100 aa. Probable gene remnant; transposase (partial) 1949853 2648946 DIP1897 Corynebacterium diphtheriae NCTC 13129 transposase (partial) NP_940234.1 1949524 D 257309 CDS NP_940235.1 38234468 2648948 1950742..1952253 1 NC_002935.2 N-terminus is similar to the N-terminal region of Escherichia coli cytochrome D ubiquinol oxidase subunit I CydA SW:CYDA_ECOLI (P11026) (522 aa) fasta scores: E(): 5.2e-47, 37.11% id in 485 aa. Similar to Mycobacterium tuberculosis probable cytochrome D ubiquinol oxidase subunit Rv1623c TR:O06140 (EMBL:Z95554) (485 aa) fasta scores: E(): 4.5e-121, 62.11% id in 483 aa; cytochrome ubiquinol oxidase subunit 1952253 2648948 DIP1898 Corynebacterium diphtheriae NCTC 13129 cytochrome ubiquinol oxidase subunit NP_940235.1 1950742 D 257309 CDS NP_940236.1 38234469 2648949 1952261..1953235 1 NC_002935.2 Similar to Escherichia coli cytochrome D ubiquinol oxidase subunit II CydB SW:CYDB_ECOLI (P11027) (379 aa) fasta scores: E(): 9.8e-28, 37.63% id in 364 aa, and to Corynebacterium glutamicum cytochrome BD-type menaquinol oxidase subunit II CydB TR:Q9KWL7 (EMBL:AB035086) (334 aa) fasta scores: E(): 3.4e-63, 54.26% id in 328 aa; cytochrome ubiquinol oxidase subunit 1953235 2648949 DIP1899 Corynebacterium diphtheriae NCTC 13129 cytochrome ubiquinol oxidase subunit NP_940236.1 1952261 D 257309 CDS NP_940237.1 38234470 2648950 1953232..1954803 1 NC_002935.2 Similar to Bacillus subtilis transport ATP-binding protein CydC SW:CYDC_BACSU (P94366) (567 aa) fasta scores: E(): 2.3e-21, 31.8% id in 544 aa, and to Vibrio cholerae transport ATP-binding protein VC1181 TR:Q9KSS5 (EMBL:AE004198) (595 aa) fasta scores: E(): 2.5e-19, 27.76% id in 551 aa. CDS is extended at the N-terminus in comparison to similar proteins. Possible alternative translational start site; ABC transporter ATP-binding protein 1954803 2648950 DIP1900 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_940237.1 1953232 D 257309 CDS NP_940238.1 38234471 2648951 1954800..1956347 1 NC_002935.2 Similar to Mycobacterium tuberculosis Rv1620c TR:O06137 (EMBL:Z95554) (576 aa) fasta scores: E(): 2.2e-20, 38.71% id in 527 aa, and to Caulobacter crescentus ABC transporter, ATP-binding protein CC0761 TR:Q9AA45 (EMBL:AE005752) (546 aa) fasta scores: E(): 5.8e-16, 28.73% id in 529 aa; ABC transporter ATP-binding protein 1956347 2648951 DIP1901 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_940238.1 1954800 D 257309 CDS NP_940239.1 38234472 2648952 complement(1956426..1957979) 1 NC_002935.2 Similar to Clostridium kluyveri succinyl-CoA:coenzyme A transferase Cat1 SWALL:CAT1_CLOKL (SWALL:P38946) (538 aa) fasta scores: E(): 1.8e-85, 47.56% id in 513 aa, and to Caulobacter crescentus coenzyme A transferase, CC3724 SWALL:Q9A242 (EMBL:AE006030) (514 aa) fasta scores: E(): 1.3e-97, 52.96% id in 506 aa; succinyl-CoA:coenzyme A transferase 1957979 cat1 2648952 cat1 Corynebacterium diphtheriae NCTC 13129 succinyl-CoA:coenzyme A transferase NP_940239.1 1956426 R 257309 CDS NP_940240.1 38234473 2648953 1958274..1959425 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical protein Rv0823c SW:Y823_MYCTU (O53835) (389 aa) fasta scores: E(): 4.4e-98, 65.69% id in 379 aa, and to Streptomyces coelicolor hypothetical protein SCC82.03c TR:Q9RDC6 (EMBL:AL133471) (406 aa) fasta scores: E(): 3.6e-62, 53.75% id in 400 aa; hypothetical protein 1959425 2648953 DIP1903 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940240.1 1958274 D 257309 CDS NP_940241.1 38234474 2648954 1959444..1960196 1 NC_002935.2 Similar to Mycobacterium tuberculosis phosphate transport system protein PhoU homolog 2 Rv0821c SW:PHU2_MYCTU (O53833) (213 aa) fasta scores: E(): 2.1e-32, 42.72% id in 213 aa, and to Mycobacterium leprae phosphate transport system protein PhoU homolog 1 ML2188 SW:PHU1_MYCLE (Q50047) (222 aa) fasta scores: E(): 8.5e-31, 40.93% id in 215 aa; hypothetical protein 1960196 2648954 DIP1904 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940241.1 1959444 D 257309 CDS NP_940242.1 38234475 2648955 complement(1960346..1960558) 1 NC_002935.2 Doubtful CDS. No significant database matches; hypothetical protein 1960558 2648955 DIP1905 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940242.1 1960346 R 257309 CDS NP_940243.1 38234476 2648957 complement(1961506..1962369) 1 NC_002935.2 Similar to Escherichia coli phosphate transport system permease PstA SW:PSTA_ECOLI (P07654) (296 aa) fasta scores: E(): 5.5e-27, 35.48% id in 279 aa, and to Mycobacterium tuberculosis phosphate transport system permease Rv0930 TR:AAK45204 (EMBL:X75297) (304 aa) fasta scores: E(): 1.3e-48, 47.65% id in 277 aa. CDS contains a truncated N-terminus in comparison to othologues; phosphate ABC transporter permease 1962369 pstA 2648957 pstA Corynebacterium diphtheriae NCTC 13129 phosphate ABC transporter permease NP_940243.1 1961506 R 257309 CDS NP_940244.1 38234477 2648958 complement(1962383..1963408) 1 NC_002935.2 Similar to Escherichia coli, and phosphate transport system permease PstC SW:PSTC_ECOLI (P07653) (319 aa) fasta scores: E(): 3.5e-26, 32.69% id in 312 aa, and to Mycobacterium tuberculosis phosphate transport system permease Rv0929 TR:O86344 (EMBL:Z47983) (324 aa) fasta scores: E(): 2.8e-43, 46.12% id in 310 aa; phosphate ABC transporter permease 1963408 pstC 2648958 pstC Corynebacterium diphtheriae NCTC 13129 phosphate ABC transporter permease NP_940244.1 1962383 R 257309 CDS NP_940245.1 38234478 2648959 complement(1963421..1964506) 1 NC_002935.2 Similar to Escherichia coli phosphate-binding periplasmic protein precursor PstS SW:PSTS_ECOLI (P06128) (346 aa) fasta scores: E(): 5e-20, 29.16% id in 360 aa, and to Mycobacterium avium phosphate-binding protein 3 precursor PstS3 TR:Q9KK89 (EMBL:AF137360) (369 aa) fasta scores: E(): 4.6e-50, 42.23% id in 367 aa; phosphate-binding periplasmic protein 1964506 2648959 DIP1910 Corynebacterium diphtheriae NCTC 13129 phosphate-binding periplasmic protein NP_940245.1 1963421 R 257309 CDS NP_940246.1 38234479 2648960 complement(1964778..1965689) 1 NC_002935.2 Similar to Mycobacterium leprae acetyltransferase ML2193 TR:Q9CBC9 (EMBL:AL583924) (311 aa) fasta scores: E(): 3.4e-22, 35.5% id in 307 aa, and to Mycobacterium tuberculosis hypothetical protein Rv0819 TR:O53831 (EMBL:AL022004) (315 aa) fasta scores: E(): 6e-19, 33.33% id in 312 aa; acetyltransferase 1965689 2648960 DIP1911 Corynebacterium diphtheriae NCTC 13129 acetyltransferase NP_940246.1 1964778 R 257309 CDS NP_940247.1 38234480 2648961 1965728..1966531 1 NC_002935.2 Poor database matches. Similar to Mycobacterium leprae probable exported protein ML2195 TR:Q50040 (EMBL:U15182) (283 aa) fasta scores: E(): 0.44, 23.39% id in 265 aa; hypothetical protein 1966531 2648961 DIP1912 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940247.1 1965728 D 257309 CDS NP_940248.1 38234481 2648962 complement(1966561..1967583) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical protein Rv3218 TR:O05848 (EMBL:Z95120) (321 aa) fasta scores: E(): 1.1e-27, 33.43% id in 329 aa, and to Streptomyces coelicolor hypothetical protein 2SC7G11.03c TR:Q9F3M0 (EMBL:AL391763) (322 aa) fasta scores: E(): 2.2e-22, 37.69% id in 329 aa; hypothetical protein 1967583 2648962 DIP1913 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940248.1 1966561 R 257309 CDS NP_940249.1 38234482 2648963 1967623..1968300 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical protein Rv0813c TR:O53827 (EMBL:AL022004) (226 aa) fasta scores: E(): 2.9e-33, 45.97% id in 211 aa, and to Mycobacterium leprae hypothetical protein ML2200 TR:Q9CBC6 (EMBL:AL583924) (228 aa) fasta scores: E(): 4.3e-32, 43.66% id in 229 aa; hypothetical protein 1968300 2648963 DIP1915 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940249.1 1967623 D 257309 CDS NP_940250.1 38234483 2648964 complement(1968307..1969203) 1 NC_002935.2 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 1969203 2648964 DIP1916 Corynebacterium diphtheriae NCTC 13129 4-amino-4-deoxychorismate lyase NP_940250.1 1968307 R 257309 CDS NP_940251.1 38234484 2648965 1969299..1970360 1 NC_002935.2 Similar to Corynebacterium ammoniagenes hypothetical protein Orf4 TR:Q9RHX9 (EMBL:AB003158) (359 aa) fasta scores: E(): 7.6e-61, 49.17% id in 362 aa, and to Mycobacterium tuberculosis hypothetical protein Rv0811c TR:O53825 (EMBL:AL022004) (368 aa) fasta scores: E(): 7.9e-11, 42.29% id in 357 aa; hypothetical protein 1970360 2648965 DIP1917 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940251.1 1969299 D 257309 CDS NP_940252.1 38234485 2648966 1970581..1970787 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical protein Rv0810c TR:O53824 (EMBL:AL022004) (60 aa) fasta scores: E(): 9.9e-07, 49.23% id in 65 aa, and to Streptomyces coelicolor hypothetical protein SCD25.24c TR:Q9RKJ8 (EMBL:AL118514) (84 aa) fasta scores: E(): 2.1e-07, 52.23% id in 67 aa; hypothetical protein 1970787 2648966 DIP1918 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940252.1 1970581 D 257309 CDS NP_940253.1 38234486 2648967 complement(1970918..1971982) 1 NC_002935.2 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 1971982 purM 2648967 purM Corynebacterium diphtheriae NCTC 13129 phosphoribosylaminoimidazole synthetase NP_940253.1 1970918 R 257309 CDS NP_940254.1 38234487 2648968 complement(1972042..1973523) 1 NC_002935.2 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 1973523 purF 2648968 purF Corynebacterium diphtheriae NCTC 13129 amidophosphoribosyltransferase NP_940254.1 1972042 R 257309 CDS NP_940255.1 38234488 2648969 complement(1973657..1974052) 1 NC_002935.2 Similar to Corynebacterium ammoniagenes hypothetical protein Orf3 TR:Q9RHY2 (EMBL:AB003158) (132 aa) fasta scores: E(): 4.5e-26, 61.15% id in 121 aa, and to Mycobacterium tuberculosis hypothetical protein Rv0807 TR:O06627 (EMBL:Z95618) (129 aa) fasta scores: E(): 2.3e-24, 57.48% id in 127 aa; hypothetical protein 1974052 2648969 DIP1921 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940255.1 1973657 R 257309 CDS NP_940256.1 38234489 2648970 complement(1974391..1975179) 1 NC_002935.2 Similar to Corynebacterium ammoniagenes hypothetical protein Orf1 TR:Q9RHY4 (EMBL:AB003158) (245 aa) fasta scores: E(): 3.5e-52, 56.65% id in 233 aa, and to Streptomyces coelicolor conserved hypothetical membrane protein 2SCK36.01c TR:CAC40591 (EMBL:AL591857) (234 aa) fasta scores: E(): 2.2e-26, 38.62% id in 233 aa; hypothetical protein 1975179 2648970 DIP1922 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940256.1 1974391 R 257309 CDS NP_940257.1 38234490 2648971 1975317..1975742 1 NC_002935.2 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 1975742 nrdI 2648971 nrdI Corynebacterium diphtheriae NCTC 13129 ribonucleotide reductase stimulatory protein NP_940257.1 1975317 D 257309 CDS NP_940258.1 38234491 2648972 1975739..1976764 1 NC_002935.2 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1976764 nrdF 2648972 nrdF Corynebacterium diphtheriae NCTC 13129 ribonucleotide-diphosphate reductase subunit beta NP_940258.1 1975739 D 257309 CDS NP_940259.1 38234492 2648974 complement(1978463..1978933) 1 NC_002935.2 Similar to Caulobacter crescentus glutathione peroxidase CC1730 TR:Q9A7J3 (EMBL:AE005847) (160 aa) fasta scores: E(): 9.7e-24, 45.39% id in 152 aa, and to Pseudomonas aeruginosa glutathione peroxidase PA0838 TR:Q9I5A2 (EMBL:AE004518) (160 aa) fasta scores: E(): 9.7e-24, 44.15% id in 154 aa; glutathione peroxidase 1978933 2648974 DIP1925 Corynebacterium diphtheriae NCTC 13129 glutathione peroxidase NP_940259.1 1978463 R 257309 CDS NP_940260.1 38234493 2648975 complement(1978935..1981064) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 protease II MT0805 TR:AAK45047 (EMBL:AE006971) (718 aa) fasta scores: E(): 1.1e-159, 55.68% id in 695 aa, and to Mycobacterium leprae ML2226 TR:O05748 (EMBL:Z95151) (724 aa) fasta scores: E(): 8.2e-148, 52.36% id in 699 aa; prolyl oligopeptidase 1981064 2648975 DIP1926 Corynebacterium diphtheriae NCTC 13129 prolyl oligopeptidase NP_940260.1 1978935 R 257309 CDS NP_940261.1 38234494 2648976 complement(1981355..1982248) 1 NC_002935.2 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazolesuccinocarboxamide synthase 1982248 hemH 2648976 hemH Corynebacterium diphtheriae NCTC 13129 phosphoribosylaminoimidazolesuccinocarboxamide synthase NP_940261.1 1981355 R 257309 CDS NP_940262.1 38234495 2648977 complement(1982334..1983773) 1 NC_002935.2 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1983773 purB 2648977 purB Corynebacterium diphtheriae NCTC 13129 adenylosuccinate lyase NP_940262.1 1982334 R 257309 CDS NP_940263.1 38234496 2648978 complement(1983773..1984909) 1 NC_002935.2 Similar to Thermus aquaticus aspartate aminotransferase AspC SW:AAT_THETH (Q56232) (385 aa) fasta scores: E(): 1.1e-29, 32.95% id in 352 aa, and to Mycobacterium tuberculosis hypothetical protein Rv3565 TR:P96847 (EMBL:Z92774) (388 aa) fasta scores: E(): 6.4e-68, 48.15% id in 380 aa; aspartate aminotransferase 1984909 2648978 DIP1929 Corynebacterium diphtheriae NCTC 13129 aspartate aminotransferase NP_940263.1 1983773 R 257309 CDS NP_940264.1 38234497 2648979 complement(1984920..1985576) 1 NC_002935.2 Similar to Bacillus halodurans potassium uptake protein BH2663 TR:Q9K9I4 (EMBL:AP001516) (220 aa) fasta scores: E(): 1.2e-20, 34.29% id in 207 aa, and to Staphylococcus aureus (strain N315) hypothetical protein SA0939 TR:Q99V10 (EMBL:AP003132) (220 aa) fasta scores: E(): 4.6e-20, 35.09% id in 208 aa; hypothetical protein 1985576 2648979 DIP1930 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940264.1 1984920 R 257309 CDS NP_940265.1 38234498 2648980 complement(1985569..1986903) 1 NC_002935.2 Similar to Enterococcus hirae V-type sodium ATP synthase subunit J NtpJ SW:NTPJ_ENTHR (P43440) (451 aa) fasta scores: E(): 3.8e-45, 36.94% id in 452 aa, and to Synechocystis sp Na+-ATPase subunit J SLR1509 TR:P73949 (EMBL:D90911) (444 aa) fasta scores: E(): 4.3e-49, 39.68% id in 446 aa; sodium transport protein 1986903 2648980 DIP1931 Corynebacterium diphtheriae NCTC 13129 sodium transport protein NP_940265.1 1985569 R 257309 CDS NP_940266.1 38234499 2648981 complement(1986987..1988273) 1 NC_002935.2 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 1988273 purD 2648981 purD Corynebacterium diphtheriae NCTC 13129 phosphoribosylamine--glycine ligase NP_940266.1 1986987 R 257309 CDS NP_940267.1 38234500 2648982 1988352..1988777 1 NC_002935.2 Similar to Rhodococcus sp. S9 HIT-like protein TR:Q9L4T6 (EMBL:AF265258) (141 aa) fasta scores: E(): 1.4e-24, 52.98% id in 134 aa, and to Mycobacterium leprae hypothetical HIT-like protein ML2237 SW:YHI1_MYCLE (P49774) (134 aa) fasta scores: E(): 1.1e-23, 50.37% id in 133 aa; HIT family protein 1988777 2648982 DIP1933 Corynebacterium diphtheriae NCTC 13129 HIT family protein NP_940267.1 1988352 D 257309 CDS NP_940268.1 38234501 2648983 1988794..1989459 1 NC_002935.2 No significant database matches to the full length CDS. C-terminus is similar to the C-terminal regions of Streptomyces coelicolor secreted lipase SCD63A.10c TR:Q9KY65 (EMBL:AL356832) (331 aa) fasta scores: E(): 0.00018, 31.3% id in 214 aa, and Streptomyces coelicolor lipase 2SCG18.12c TR:Q9K3H5 (EMBL:AL390188) (289 aa) fasta scores: E(): 0.00064, 28.94% id in 190 aa; hypothetical protein 1989459 2648983 DIP1934 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940268.1 1988794 D 257309 CDS NP_940269.1 38234502 2648984 complement(1989473..1991032) 1 NC_002935.2 C-terminal region is similar to Mycobacterium tuberculosis hypothetical protein Rv0758 TR:P71815 (EMBL:Z80226) (485 aa) fasta scores: E(): 7.7e-38, 42.88% id in 471 aa, and to Bacillus halodurans two-component sensor histidine kinase BH0373 TR:Q9KFU8 (EMBL:AP001508) (459 aa) fasta scores: E(): 3.7e-29, 30.81% id in 464 aa; two somponent system sensor kinase 1991032 2648984 DIP1935 Corynebacterium diphtheriae NCTC 13129 two somponent system sensor kinase NP_940269.1 1989473 R 257309 CDS NP_940270.1 38234503 2648985 complement(1991068..1991778) 1 NC_002935.2 Similar to Bacillus subtilis alkaline phosphatase synthesis transcriptional regulatory protein PhoP SW:PHOP_BACSU (P13792) (240 aa) fasta scores: E(): 1.3e-32, 42.37% id in 236 aa, and to Mycobacterium tuberculosis hypothetical PhoP-like protein Rv0757 TR:AAK45023 (EMBL:Z80226) (240 aa) fasta scores: E(): 3.2e-57, 66.37% id in 226 aa; two component system response regulator protein 1991778 2648985 DIP1936 Corynebacterium diphtheriae NCTC 13129 two component system response regulator protein NP_940270.1 1991068 R 257309 CDS NP_940271.1 38234504 2648986 1992160..1992726 1 NC_002935.2 Poor database matches. Similar to the C-terminal region of Bacillus subtilis extracellular metalloprotease precursor Mpr SW:MPR_BACSU (P39790) (313 aa) fasta scores: E(): 8.9, 23.76% id in 202 aa; hypothetical protein 1992726 2648986 DIP1937 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940271.1 1992160 D 257309 CDS NP_940272.1 38234505 2648987 1992696..1992968 1 NC_002935.2 hypothetical protein 1992968 2648987 DIP1938 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940272.1 1992696 D 257309 CDS NP_940273.1 38234506 2648988 1992968..1993156 1 NC_002935.2 Similar to the N-terminus of Thermotoga maritima conserved hypothetical protein TM1156 TR:Q9X0P0 (EMBL:AE001773) (129 aa) fasta scores: E(): 5.1e-05, 39.34% id in 61 aa, and to the full length Bacillus subtilis hypothetical protein YvlC TR:O34719 (EMBL:AF017113) (65 aa) fasta scores: E(): 0.00018, 41.37% id in 58 aa; hypothetical protein 1993156 2648988 DIP1939 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940273.1 1992968 D 257309 CDS NP_940274.1 38234507 2648989 1993265..1993411 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 1993411 2648989 DIP1940 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940274.1 1993265 D 257309 CDS NP_940275.1 38234508 2648990 1993436..1994935 1 NC_002935.2 Similar to Salmonella typhimurium methyl viologen resistance protein SmvA SW:SMVA_SALTY (P37594) (496 aa) fasta scores: E(): 4e-41, 33.4% id in 488 aa, and to Pseudomonas aeruginosa probable MFS transporter PA1282 TR:Q9I462 (EMBL:AE004557) (501 aa) fasta scores: E(): 1.2e-55, 41.17% id in 493 aa; hypothetical protein 1994935 2648990 DIP1941 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940275.1 1993436 D 257309 CDS NP_940276.1 38234509 2648991 1994922..1995542 1 NC_002935.2 Similar to Synechocystis sp hypothetical protein SLR0895 TR:Q55363 (EMBL:D64003) (187 aa) fasta scores: E(): 6.6e-05, 24% id in 175 aa, and to Rhizobium meliloti hypothetical protein SMC01522 TR:CAC46995 (EMBL:AL591790) (186 aa) fasta scores: E(): 7.7e-05, 25.88% id in 170 aa; TetR family regulatory protein 1995542 2648991 DIP1942 Corynebacterium diphtheriae NCTC 13129 TetR family regulatory protein NP_940276.1 1994922 D 257309 CDS NP_940277.1 38234510 2648992 1995598..1997511 1 NC_002935.2 Similar to Streptomyces coelicolor permease SC9G1.04 TR:Q9RKW2 (EMBL:AL132997) (462 aa) fasta scores: E(): 5.6e-61, 41.93% id in 465 aa, and to Escherichia coli purine permease YgfU SW:YGFU_ECOLI (Q46821) (482 aa) fasta scores: E(): 9e-55, 38.08% id in 449 aa; xanthine/uracil permeases family protein 1997511 2648992 DIP1943 Corynebacterium diphtheriae NCTC 13129 xanthine/uracil permeases family protein NP_940277.1 1995598 D 257309 CDS NP_940278.1 38234511 2648993 1998063..1998857 1 NC_002935.2 Almost identical to Salmonella enterica subsp enterica serovar Typhimurium transposase TnpA TR:Q9FDH9 (EMBL:AF261825) (264 aa) fasta scores: E(): 7e-112, 99.62% id in 264 aa, and to Mycobacterium fortuitum transposase Tnp TR:Q49185 (EMBL:X53635) (254 aa) fasta scores: E(): 6.7e-107, 99.6% id in 254 aa. Note: This CDS is duplicated downstream in CDIP1951 (264 aa) fasta scores: E(): 2.7e-119, 100.000% identity in 264 aa overlap; transposase 1998857 tnpA2 2648993 tnpA2 Corynebacterium diphtheriae NCTC 13129 transposase NP_940278.1 1998063 D 257309 CDS NP_940279.1 38234512 2648994 complement(1998829..1999494) 1 NC_002935.2 N-terminus is identical to the N-terminal regions of Mycobacterium fortuitum integrase Orf2M TR:Q49186 (EMBL:X53635) (303 aa) fasta scores: E(): 3.6e-79, 100% id in 194 aa, and Acinetobacter baumannii integraseTtnp1 TR:AAA56784 (EMBL:U17586) (337 aa) fasta scores: E(): 4e-79, 100% id in 194 aa; integrase 1999494 2648994 DIP1947 Corynebacterium diphtheriae NCTC 13129 integrase NP_940279.1 1998829 R 257309 CDS NP_940280.1 38234513 2648995 1999595..2000446 1 NC_002935.2 Almost identical to Escherichia coli dihydropteroate synthase type I SulI SW:DHP1_ECOLI (P11744) (279 aa) fasta scores: E(): 3.1e-105, 99.64% id in 278 aa, and to Corynebacterium glutamicum sufamethoxazole resistance protein SulI TR:AAG00283 (EMBL:AF164956) (279 aa) fasta scores: E(): 3.1e-105, 99.64% id in 278 aa. Orthologues are implicated in resistance to sulfonamide and are located on various large self-transmissible plasmids and transposons related to Tn21; dihydropteroate synthase 2000446 2648995 DIP1948 Corynebacterium diphtheriae NCTC 13129 dihydropteroate synthase NP_940280.1 1999595 D 257309 CDS NP_940281.1 38234514 2648996 2000574..2001074 1 NC_002935.2 Identical to Escherichia coli hypothetical protein YbbA TR:P75025 (EMBL:U12441) (166 aa) fasta scores: E(): 1.6e-70, 100% id in 166 aa, and to Acinetobacter baumannii hypothetical protein TR:AAK72477 (EMBL:AY038837) (142 aa) fasta scores: E(): 4.2e-59, 100% id in 142 aa; acetyltransferase 2001074 2648996 DIP1949 Corynebacterium diphtheriae NCTC 13129 acetyltransferase NP_940281.1 2000574 D 257309 CDS NP_940282.1 38234515 2648997 2001098..2001385 1 NC_002935.2 Poor database matches. Identical to Salmonella enterica subsp enterica serovar Typhimurium hypothetical protein TR:Q9FDI0 (EMBL:AF261825) (95 aa) fasta scores: E(): 3.9e-37, 100% id in 95 aa; hypothetical protein 2001385 2648997 DIP1950 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940282.1 2001098 D 257309 CDS NP_940283.1 38234516 2648998 2001551..2002345 1 NC_002935.2 Almost identical to Salmonella enterica subsp enterica serovar Typhimurium transposase TnpA TR:Q9FDH9 (EMBL:AF261825) (264 aa) fasta scores: E(): 6.6e-112, 99.62% id in 264 aa, and Mycobacterium fortuitum transposase Tnp TR:Q49185 (EMBL:X53635) (254 aa) fasta scores: E(): 6.4e-107, 99.6% id in 254 aa, Note: This CDS is duplicated upstream in CDIP1944 (264 aa) fasta scores: E(): 2.7e-119, 100.000% identity in 264 aa overlap; transposase 2002345 tnpA3 2648998 tnpA3 Corynebacterium diphtheriae NCTC 13129 transposase NP_940283.1 2001551 D 257309 CDS NP_940284.1 38234517 2648999 complement(2002457..2004193) 1 NC_002935.2 catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase 2004193 2648999 DIP1952 Corynebacterium diphtheriae NCTC 13129 pyruvate dehydrogenase NP_940284.1 2002457 R 257309 CDS NP_940285.1 38234518 2649000 2004306..2005757 1 NC_002935.2 Similar to Corynebacterium glutamicum threonine export carrier protein ThrE TR:AAK61331 (EMBL:AF326510) (489 aa) fasta scores: E(): 3.8e-75, 48.76% id in 445 aa, and to Mycobacterium tuberculosis membrane protein Rv3737 TR:O69704 (EMBL:AL022121) (529 aa) fasta scores: E(): 2.2e-29, 31.15% id in 414 aa. Note: Also similar to DIP1964 (514 aa) fasta scores: E(): 7.1e-58, 44.662% identity in 459 aa overlap; amino acid export carrier protein 2005757 2649000 DIP1953 Corynebacterium diphtheriae NCTC 13129 amino acid export carrier protein NP_940285.1 2004306 D 257309 CDS NP_940286.1 38234519 2649001 complement(2006198..2007007) 1 NC_002935.2 Similar to Escherichia coli transposase for insertion sequence element IS150, InsK SW:INSK_ECOLI (P19769) (283 aa) fasta scores: E(): 3.2e-41, 43.23% id in 266 aa, and to Klebsiella pneumoniae hypothetical protein OrfB TR:Q9AG21 (EMBL:AF345899) (281 aa) fasta scores: E(): 1.3e-42, 45.45% id in 264 aa. CDS contains fewer amino acids at the N-terminus in comparison to orthologues; transposase 2007007 2649001 DIP1955 Corynebacterium diphtheriae NCTC 13129 transposase NP_940286.1 2006198 R 257309 CDS NP_940287.1 38234520 2649002 complement(2007058..2007495) 1 NC_002935.2 C-terminal regions is similar to Streptococcus agalactiae hypothetical protein TR:Q53639 (EMBL:M22449) (141 aa) fasta scores: E(): 1.3e-06, 32.43% id in 111 aa, and to Marinococcus halophilus transposase TR:O06062 (EMBL:U66614) (110 aa) fasta scores: E(): 0.051, 27.18% id in 103 aa; hypothetical protein 2007495 2649002 DIP1956 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940287.1 2007058 R 257309 CDS NP_940288.1 38234521 2649003 complement(2007631..2007888) 1 NC_002935.2 hypothetical protein 2007888 2649003 DIP1957 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940288.1 2007631 R 257309 CDS NP_940289.1 38234522 2649004 2008028..2008507 1 NC_002935.2 DNA-binding protein 2008507 2649004 DIP1958 Corynebacterium diphtheriae NCTC 13129 DNA-binding protein NP_940289.1 2008028 D 257309 CDS NP_940290.1 38234523 2649005 2008563..2008877 1 NC_002935.2 Poor database matches. Similar to the C-terminal region of Bacillus halodurans hypothetical protein BH3550 TR:Q9K723 (EMBL:AP001519) (146 aa) fasta scores: E(): 0.85, 32.03% id in 103 aa; hypothetical protein 2008877 2649005 DIP1959 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940290.1 2008563 D 257309 CDS NP_940291.1 38234524 2649006 2009016..2009465 1 NC_002935.2 C-terminus is similar to the C-terminal region of Bacillus subtilis hypothetical protein YqxI SW:YQXI_BACSU (P24812) (159 aa) fasta scores: E(): 7.6, 26.04% id in 96 aa; hypothetical protein 2009465 2649006 DIP1960 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940291.1 2009016 D 257309 CDS NP_940292.1 38234525 2649007 2009462..2009800 1 NC_002935.2 hypothetical protein 2009800 2649007 DIP1961 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940292.1 2009462 D 257309 CDS NP_940293.1 38234526 2649008 complement(2009896..2010234) 1 NC_002935.2 hypothetical protein 2010234 2649008 DIP1962 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940293.1 2009896 R 257309 CDS NP_940294.1 38234527 2649009 2010331..2011782 1 NC_002935.2 Similar to Escherichia coli possible transposase of IS1353 YahA TR:Q9WTH9 (EMBL:AP000342) (514 aa) fasta scores: E(): 1.7e-62, 41.81% id in 464 aa, and to Agrobacterium tumefaciens str. C58 possible transposase of IS1353 AGR_C_3822 TR:AAK87856 (EMBL:AE008127) (512 aa) fasta scores: E(): 2.7e-58, 39.13% id in 460 aa; transposase 2011782 2649009 DIP1963 Corynebacterium diphtheriae NCTC 13129 transposase NP_940294.1 2010331 D 257309 CDS NP_940295.1 38234528 2649011 2012164..2013708 1 NC_002935.2 Similar to Corynebacterium glutamicum ThrEonine export carrier protein ThrE TR:AAK61331 (EMBL:AF326510) (489 aa) fasta scores: E(): 7e-110, 63.45% id in 487 aa, and to Mycobacterium tuberculosis membrane protein Rv3737 TR:O69704 (EMBL:AL022121) (529 aa) fasta scores: E(): 1.6e-37, 36.1% id in 421 aa. Note: Also similar to DIP1953 (483 aa) fasta scores: E(): 3.6e-61, 44.662% identity in 459 aa overlap; amino acid export carrier protein 2013708 2649011 DIP1964 Corynebacterium diphtheriae NCTC 13129 amino acid export carrier protein NP_940295.1 2012164 D 257309 CDS NP_940296.1 38234529 2649012 2013769..2014113 1 NC_002935.2 Limited database matches. Similar to Chlamydia muridarum histone H1-like protein TC0119 SW:HCT1_CHLMU (Q9PLI1) (125 aa) fasta scores: E(): 0.19, 35.39% id in 113 aa, and to Chlamydia trachomatis histone H1-like protein CT743 SW:HCT1_CHLTR (Q02281) (125 aa) fasta scores: E(): 0.22, 35.39% id in 113 aa. CDS contains a C-terminal lysine rich region; hypothetical protein 2014113 2649012 DIP1965 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940296.1 2013769 D 257309 CDS NP_940297.1 38234530 2649013 2014122..2015561 1 NC_002935.2 Similar to Schizosaccharomyces pombe alpha,alpha-trehalose-phosphate synthase [UDP-forming] TPS1 SW:TPS1_SCHPO (P40387) (513 aa) fasta scores: E(): 7e-55, 36.68% id in 477 aa, and to Mycobacterium tuberculosis alpha,alpha-trehalose-phosphate synthase Rv3490 TR:O06353 (EMBL:Z95390) (500 aa) fasta scores: E(): 3.1e-98, 55.18% id in 482 aa; glycosyltransferase 2015561 2649013 DIP1966 Corynebacterium diphtheriae NCTC 13129 glycosyltransferase NP_940297.1 2014122 D 257309 CDS NP_940298.1 38234531 2649014 2015595..2016071 1 NC_002935.2 hypothetical protein 2016071 2649014 DIP1967 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940298.1 2015595 D 257309 CDS NP_940299.1 38234532 2649015 2016061..2016819 1 NC_002935.2 Similar to Escherichia coli trehalose-phosphatase OtsB SW:OTSB_ECOLI (P31678) (266 aa) fasta scores: E(): 1.8e-10, 30.3% id in 231 aa, and to Salmonella typhimurium trehalose-phosphatase STM1929 SW:OTSB_SALTY (Q9L894) (267 aa) fasta scores: E(): 5.1e-11, 29.78% id in 235 aa; trehalose-phosphatase 2016819 2649015 DIP1968 Corynebacterium diphtheriae NCTC 13129 trehalose-phosphatase NP_940299.1 2016061 D 257309 CDS NP_940300.1 38234533 2649016 complement(2016782..2017921) 1 NC_002935.2 Similar to Escherichia coli raffinose operon repressor RafR SW:RAFR_ECOLI (P21867) (335 aa) fasta scores: E(): 1.5e-08, 24.52% id in 367 aa, and to Mycobacterium tuberculosis hypothetical protein Rv3575c TR:P96857 (EMBL:Z92774) (359 aa) fasta scores: E(): 1.8e-50, 45.82% id in 371 aa; LacI family transcriptional regulator 2017921 2649016 DIP1969 Corynebacterium diphtheriae NCTC 13129 LacI family transcriptional regulator NP_940300.1 2016782 R 257309 CDS NP_940301.1 38234534 2649017 complement(2017931..2018872) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical protein Rv3579c TR:P96861 (EMBL:Z92774) (322 aa) fasta scores: E(): 1.1e-61, 58.33% id in 312 aa, and to Streptomyces coelicolor tRNA/rRNA methyltransferase SCD8A.09 TR:Q9L0Q5 (EMBL:AL160331) (314 aa) fasta scores: E(): 2.7e-57, 55.97% id in 318 aa; SpoU rRNA methylase 2018872 2649017 DIP1970 Corynebacterium diphtheriae NCTC 13129 SpoU rRNA methylase NP_940301.1 2017931 R 257309 CDS NP_940302.1 38234535 2649018 complement(2018900..2020291) 1 NC_002935.2 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 2020291 cysS 2649018 cysS Corynebacterium diphtheriae NCTC 13129 cysteinyl-tRNA synthetase NP_940302.1 2018900 R 257309 CDS NP_940303.1 38234536 2649019 complement(2020310..2020792) 1 NC_002935.2 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclo diphosphate synthase 2020792 ispF 2649019 ispF Corynebacterium diphtheriae NCTC 13129 2-C-methyl-D-erythritol 2,4-cyclo diphosphate synthase NP_940303.1 2020310 R 257309 CDS NP_940304.1 38234537 2649020 complement(2020785..2021519) 1 NC_002935.2 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2021519 ispD 2649020 ispD Corynebacterium diphtheriae NCTC 13129 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NP_940304.1 2020785 R 257309 CDS NP_940305.1 38234538 2649021 complement(2021529..2022110) 1 NC_002935.2 N-terminal region is similar to Mycobacterium tuberculosis transcriptional factor Rv3583c TR:O53568 (EMBL:AL022075) (162 aa) fasta scores: E(): 6.8e-38, 71.69% id in 159 aa, and to Mycobacterium leprae transcription factor ML0320 TR:Q9CCW7 (EMBL:AL583918) (165 aa) fasta scores: E(): 1.2e-37, 70.44% id in 159 aa; CarD-like transcriptional factor 2022110 2649021 DIP1974 Corynebacterium diphtheriae NCTC 13129 CarD-like transcriptional factor NP_940305.1 2021529 R 257309 CDS NP_940306.1 38234539 2649022 complement(2022342..2022944) 1 NC_002935.2 hypothetical protein 2022944 2649022 DIP1975 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940306.1 2022342 R 257309 CDS NP_940307.1 38234540 2649023 complement(2023051..2024442) 1 NC_002935.2 No significant database matches to the full length CDS. Internal region is similar to the C-terminal region of Streptococcus pneumoniae surface protein PspC TR:Q9KK25 (EMBL:AF154033) (763 aa) fasta scores: E(): 0.081, 25.23% id in 214 aa; hypothetical protein 2024442 2649023 DIP1976 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940307.1 2023051 R 257309 CDS NP_940308.1 38234541 2649024 2024799..2026190 1 NC_002935.2 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 2026190 2649024 DIP1977 Corynebacterium diphtheriae NCTC 13129 DNA repair protein RadA NP_940308.1 2024799 D 257309 CDS NP_940309.1 38234542 2649025 complement(2026218..2026934) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical protein Rv3587c TR:O53572 (EMBL:AL022075) (264 aa) fasta scores: E(): 2.9e-10, 29.13% id in 230 aa, and to Mycobacterium leprae hypothetical membrane protein ML1918 TR:Q9CBJ2 (EMBL:AL583923) (263 aa) fasta scores: E(): 1e-08, 28.69% id in 230 aa; hypothetical protein 2026934 2649025 DIP1978 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940309.1 2026218 R 257309 CDS NP_940310.1 38234543 2649026 complement(2027004..2027633) 1 NC_002935.2 Similar to Mycobacterium tuberculosis carbonic anhydrase Rv3588c TR:O53573 (EMBL:AL022075) (207 aa) fasta scores: E(): 6.4e-31, 46.31% id in 190 aa. Weakly similar to Escherichia coli carbonic anhydrase CynT SW:CYNT_ECOLI (P17582) (219 aa) fasta scores: E(): 2.8e-09, 32.22% id in 180 aa; carbonic anhydrase 2027633 2649026 DIP1979 Corynebacterium diphtheriae NCTC 13129 carbonic anhydrase NP_940310.1 2027004 R 257309 CDS NP_940311.1 38234544 2649027 2027764..2028651 1 NC_002935.2 Similar to Mycobacterium leprae probable DNA glycosylase ML1920 TR:Q9CBJ0 (EMBL:AL583923) (297 aa) fasta scores: E(): 5.3e-52, 51.86% id in 295 aa. N-terminus is similar to the N-terminal region of Escherichia coli A/G-specific adenine glycosylase MutY SW:MUTY_ECOLI (P17802) (350 aa) fasta scores: E(): 2.9e-23, 40.48% id in 205 aa; DNA repair protein 2028651 2649027 DIP1980 Corynebacterium diphtheriae NCTC 13129 DNA repair protein NP_940311.1 2027764 D 257309 CDS NP_940312.1 38234545 2649028 complement(2028648..2029901) 1 NC_002935.2 N-terminus is similar to the C-terminal region of Rhodobacter capsulatus hypothetical 31.0 kDa protein TR:O68029 (EMBL:AF010496) (289 aa) fasta scores: E(): 5.3e-10, 28.39% id in 243 aa, and to the full length Escherichia coli hypothetical protein YjjP SW:YJJP_ECOLI (P39402) (256 aa) fasta scores: E(): 1.3e-08, 27.16% id in 254 aa; hypothetical protein 2029901 2649028 DIP1981 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940312.1 2028648 R 257309 CDS NP_940313.1 38234546 2649029 complement(2030032..2030202) 1 NC_002935.2 Poor database matches. Similar to the N-terminal region of Escherichia coli O157:H7 hypothetical protein ECS1344 TR:BAB34767 (EMBL:AE005309) (402 aa) fasta scores: E(): 9.6, 38.33% id in 60 aa. Doubtful CDS; hypothetical protein 2030202 2649029 DIP1982 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940313.1 2030032 R 257309 CDS NP_940314.1 38234547 2649030 complement(2030233..2032884) 1 NC_002935.2 Similar to Bacillus subtilis negative regulator of genetic competence ClpC SW:CLPC_BACSU (P37571) (810 aa) fasta scores: E(): 2.6e-134, 58.11% id in 826 aa, and to Mycobacterium tuberculosis probable ATP-dependent Clp protease ATP-binding subunit Rv3596c SW:CLPC_MYCTU (O06286) (848 aa) fasta scores: E(): 1.7e-186, 81.81% id in 847 aa; ATP-dependent Clp protease ATP-binding subunit 2032884 clpC 2649030 clpC Corynebacterium diphtheriae NCTC 13129 ATP-dependent Clp protease ATP-binding subunit NP_940314.1 2030233 R 257309 CDS NP_940315.1 38234548 2649031 complement(2033317..2033772) 1 NC_002935.2 Similar to Pasteurella multocida hypothetical protein PM0821 TR:Q9CMK3 (EMBL:AE006121) (150 aa) fasta scores: E(): 8.8e-19, 46% id in 150 aa, and to Deinococcus radiodurans conserved hypothetical protein DR1979 TR:Q9RSZ0 (EMBL:AE002036) (161 aa) fasta scores: E(): 8.6e-16, 42.66% id in 150 aa; hypothetical protein 2033772 2649031 DIP1984 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940315.1 2033317 R 257309 CDS NP_940316.1 38234549 2650089 2033808..2034446 1 NC_002935.2 Poor database matches. C-terminal region is similar to Rhizobium loti hypothetical protein MLL0061 TR:Q98NN3 (EMBL:AP002994) (97 aa) fasta scores: E(): 1.7, 25% id in 96 aa. Possible alternative translational start site; hypothetical protein 2034446 2650089 DIP1985 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940316.1 2033808 D 257309 CDS NP_940317.1 38234550 2650090 2034499..2035347 1 NC_002935.2 Similar to Homo sapiens monoglyceride lipase TR:CAC43316 (EMBL:AJ270950) (303 aa) fasta scores: E(): 1.6e-14, 28.88% id in 277 aa, and to Deinococcus radiodurans lipase DR1537 TR:Q9RU57 (EMBL:AE001997) (282 aa) fasta scores: E(): 4.2e-24, 33.69% id in 276 aa; hypothetical protein 2035347 2650090 DIP1986 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940317.1 2034499 D 257309 CDS NP_940318.1 38234551 2650091 complement(2035873..2037435) 1 NC_002935.2 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 2037435 lysS 2650091 lysS Corynebacterium diphtheriae NCTC 13129 lysyl-tRNA synthetase NP_940318.1 2035873 R 257309 CDS NP_940319.1 38234552 2650092 2037819..2038799 1 NC_002935.2 No significant database matches to the full length CDS. N-terminus is similar to the N-terminal region of Streptomyces coelicolor insertion element IS110 hypothetical protein SC3C8.10 SW:YIS1_STRCO (P19780) (405 aa) fasta scores: E(): 8.1e-15, 42.33% id in 137 aa, and to Shigella flexneri transposase for IS110 S0128 TR:Q9AFS5 (EMBL:AF348706) (398 aa) fasta scores: E(): 4.6e-14, 40.87% id in 137 aa; hypothetical protein 2038799 2650092 DIP1988 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940319.1 2037819 D 257309 CDS NP_940320.1 38234553 2650093 complement(2038819..2039577) 1 NC_002935.2 Weakly similar to Streptomyces coelicolor ABC transporter integral membrane protein SCC30.14 TR:Q9L007 (EMBL:AL352972) (238 aa) fasta scores: E(): 1.9e-11, 28.91% id in 249 aa, and to Bacillus cereus hypothetical protein YvfS TR:Q9L4F5 (EMBL:AJ243712) (239 aa) fasta scores: E(): 3.1e-08, 23.79% id in 248 aa; hypothetical protein 2039577 2650093 DIP1989 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940320.1 2038819 R 257309 CDS NP_940321.1 38234554 2650094 complement(2039574..2040497) 1 NC_002935.2 Similar to Rhizobium sp nodulation ATP-binding protein I NodI SW:NODI_RHIS3 (P72335) (304 aa) fasta scores: E(): 6.6e-22, 35.94% id in 306 aa, and to Streptomyces coelicolor ABC transporter ATP-binding subunit SCC30.13 TR:Q9L008 (EMBL:AL352972) (308 aa) fasta scores: E(): 2.8e-31, 39.34% id in 305 aa; ABC transporter ATP-binding protein 2040497 2650094 DIP1990 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_940321.1 2039574 R 257309 CDS NP_940322.1 38234555 2650095 2040971..2041939 1 NC_002935.2 Similar to Streptomyces coelicolor transmembrane protein SCK7.11c TR:Q9KIM1 (EMBL:AF230489) (312 aa) fasta scores: E(): 4.5e-47, 50.16% id in 301 aa. C-terminal region is similar to Streptococcus pneumoniae hypothetical protein SP2132 TR:AAK76190 (EMBL:AE007502) (335 aa) fasta scores: E(): 8.7e-22, 42.43% id in 304 aa; hypothetical protein 2041939 2650095 DIP1991 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940322.1 2040971 D 257309 CDS NP_940323.1 38234556 2650096 2042051..2043478 1 NC_002935.2 C-terminal region is similar to Escherichia coli proton glutamate symport protein GltP SW:GLTP_ECOLI (P21345) (437 aa) fasta scores: E(): 2.5e-34, 29.25% id in 417 aa, and to the C-terminal region of Caulobacter crescentus sodium:dicarboxylate symporter family protein CC1104 TR:Q9A990 (EMBL:AE005788) (476 aa) fasta scores: E(): 1.4e-90, 57.93% id in 435 aa. Possible alternative translational start site; sodium/dicarboxylate symporter family protein 2043478 2650096 DIP1992 Corynebacterium diphtheriae NCTC 13129 sodium/dicarboxylate symporter family protein NP_940323.1 2042051 D 257309 CDS NP_940324.1 38234557 2650097 complement(2043495..2044274) 1 NC_002935.2 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 2044274 panC 2650097 panC Corynebacterium diphtheriae NCTC 13129 pantoate--beta-alanine ligase NP_940324.1 2043495 R 257309 CDS NP_940325.1 38234558 2650098 complement(2044287..2044910) 1 NC_002935.2 Poor database matches. N-terminus is similar to the C-terminal region of Pseudomonas aeruginosa malonate decarboxylase alpha subunit PA0208 TR:Q9I6T0 (EMBL:AE004459) (554 aa) fasta scores: E(): 3.7, 32.31% id in 164 aa; hypothetical protein 2044910 2650098 DIP1994 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940325.1 2044287 R 257309 CDS NP_940326.1 38234559 2650099 complement(2044907..2045824) 1 NC_002935.2 Weakly similar to the N-terminal regions of Mycobacterium leprae membrane protein ML0228 TR:O69526 (EMBL:AL023093) (432 aa) fasta scores: E(): 0.025, 25.15% id in 318 aa, and to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3709 TR:AAK48067 (EMBL:AE007170) (397 aa) fasta scores: E(): 0.071, 23.51% id in 336 aa; hypothetical protein 2045824 2650099 DIP1995 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940326.1 2044907 R 257309 CDS NP_940327.1 38234560 2650100 complement(2045826..2046293) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical protein Rv3605c TR:O06277 (EMBL:Z95557) (158 aa) fasta scores: E(): 1.3e-11, 39% id in 141 aa, and to Mycobacterium leprae hypothetical protein ML0227 TR:O69527 (EMBL:AL023093) (158 aa) fasta scores: E(): 5.6e-11, 36.73% id in 147 aa; hypothetical protein 2046293 2650100 DIP1996 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940327.1 2045826 R 257309 CDS NP_940328.1 38234561 2650101 complement(2046290..2046769) 1 NC_002935.2 Similar to Escherichia coli 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK SW:HPPK_ECOLI (P26281) (158 aa) fasta scores: E(): 1.1e-11, 36.36% id in 154 aa, and to Mycobacterium tuberculosis 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Rv3606c SW:HPPK_MYCTU (O06276) (188 aa) fasta scores: E(): 6e-23, 48.93% id in 141 aa; 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase 2046769 folK 2650101 folK Corynebacterium diphtheriae NCTC 13129 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase NP_940328.1 2046290 R 257309 CDS NP_940329.1 38234562 2650102 complement(2046779..2047144) 1 NC_002935.2 Similar to Corynebacterium glutamicum dihydroneopterin aldolase CGL2693 SWALL:BAC00087 (EMBL:AP005282) (130 aa) fasta scores: E(): 1.3e-30, 66.11% id in 121 aa, and to Bacillus subtilis dihydroneopterin aldolase FolB or FolA SWALL:FOLB_BACSU (SWALL:P28823) (120 aa) fasta scores: E(): 2.4e-14, 38.98% id in 118 aa; dihydroneopterin aldolase 2047144 2650102 DIP1998 Corynebacterium diphtheriae NCTC 13129 dihydroneopterin aldolase NP_940329.1 2046779 R 257309 CDS NP_940330.1 38234563 2650103 complement(2047150..2047986) 1 NC_002935.2 Similar to Mycobacterium tuberculosis dihydropteroate synthase 1 FolP1 SW:DHP1_MYCTU (O06274) (280 aa) fasta scores: E(): 4.3e-48, 53.9% id in 269 aa, and to Streptomyces coelicolor dihydropteroate synthase SCE9.05 TR:Q9X8H8 (EMBL:AL049841) (288 aa) fasta scores: E(): 6.9e-46, 53.75% id in 266 aa; dihydropteroate synthase 2047986 2650103 DIP1999 Corynebacterium diphtheriae NCTC 13129 dihydropteroate synthase NP_940330.1 2047150 R 257309 CDS NP_940331.1 38234564 2650104 complement(2048110..2048424) 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 2048424 2650104 DIP2000 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940331.1 2048110 R 257309 CDS NP_940332.1 38234565 2650105 complement(2048427..2048999) 1 NC_002935.2 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 2048999 folE 2650105 folE Corynebacterium diphtheriae NCTC 13129 GTP cyclohydrolase I NP_940332.1 2048427 R 257309 CDS NP_940333.1 38234566 2650106 complement(2049007..2051481) 1 NC_002935.2 Similar to Mycobacterium tuberculosis cell division protein FtsH homolog Rv3610c SW:FTSH_MYCTU (P96942) (760 aa) fasta scores: E(): 8e-126, 59.01% id in 793 aa, and to Mycobacterium leprae cell division protein FtsH TR:O69532 (EMBL:AL023093) (787 aa) fasta scores: E(): 2.6e-126, 57.03% id in 817 aa; cell division protein 2051481 ftsH 2650106 ftsH Corynebacterium diphtheriae NCTC 13129 cell division protein NP_940333.1 2049007 R 257309 CDS NP_940334.1 38234567 2650107 complement(2051613..2052176) 1 NC_002935.2 Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively; hypoxanthine-guanine phosphoribosyltransferase 2052176 hpt 2650107 hpt Corynebacterium diphtheriae NCTC 13129 hypoxanthine-guanine phosphoribosyltransferase NP_940334.1 2051613 R 257309 CDS NP_940335.1 38234568 2650108 complement(2052221..2053063) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 34.1 kDa protein Rv3625c or MT3727 or MTCY15C10.27 SWALL:Y0C5_MYCTU (SWALL:O06382) (323 aa) fasta scores: E(): 5.3e-28, 45.2% id in 292 aa, and to Streptomyces coelicolor hypothetical 36.7 kDa protein SCE9.13c SWALL:Q9X8I6 (EMBL:AL049841) (352 aa) fasta scores: E(): 1.6e-07, 38.72% id in 297 aa; hypothetical protein 2053063 2650108 DIP2004 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940335.1 2052221 R 257309 CDS NP_940336.1 38234569 2650109 complement(2053092..2054372) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 46.8 kDa protein Rv3627c or MT3729 or MTCY15C10.25 SWALL:AAK48090 (EMBL:Z95436) (461 aa) fasta scores: E(): 5.2e-11, 37.04% id in 440 aa, and to Escherichia coli penicillin-binding protein 4 precursor DacB or B3182 SWALL:PBP4_ECOLI (SWALL:P24228) (477 aa) fasta scores: E(): 4.4e-05, 26.55% id in 433 aa; D-Ala D-Ala carboxypeptidase 2054372 2650109 DIP2005 Corynebacterium diphtheriae NCTC 13129 D-Ala D-Ala carboxypeptidase NP_940336.1 2053092 R 257309 CDS NP_940337.1 38234570 2650110 2054407..2054883 1 NC_002935.2 Catalyzes the hydrolysis of pyrophosphate; inorganic pyrophosphatase 2054883 ppa 2650110 ppa Corynebacterium diphtheriae NCTC 13129 inorganic pyrophosphatase NP_940337.1 2054407 D 257309 CDS NP_940338.1 38234571 2650111 2055040..2055336 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 11.5 kDa protein SCH69.09c SWALL:Q9XA25 (EMBL:AL079308) (109 aa) fasta scores: E(): 4.5e-11, 43.29% id in 97 aa, and to Bacillus subtilis hypothetical 14.6 kDa protein in gcvT-spoIIIAA intergenic region YqhL SWALL:YQHL_BACSU (SWALL:P54510) (126 aa) fasta scores: E(): 4.4e-07, 39.13% id in 92 aa; hypothetical protein 2055336 2650111 DIP2007 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940338.1 2055040 D 257309 CDS NP_940339.1 38234572 2650112 2055410..2055871 1 NC_002935.2 Similar to Caulobacter crescentus transcriptional regulator, MarR family CC3677 SWALL:Q9A289 (EMBL:AE006025) (186 aa) fasta scores: E(): 5.8e-05, 29.75% id in 121 aa, and to Escherichia coli multiple antibiotic resistance protein MarR or SoxQ or CfxB or InaR or B1530 SWALL:MARR_ECOLI (SWALL:P27245) (144 aa) fasta scores: E(): 0.00044, 30.35% id in 112 aa; MarR family transcriptional regulator 2055871 2650112 DIP2008 Corynebacterium diphtheriae NCTC 13129 MarR family transcriptional regulator NP_940339.1 2055410 D 257309 CDS NP_940340.1 38234573 2650113 2055872..2059675 1 NC_002935.2 N-terminal region similar to C-terminal region of Streptomyces lavendulae peptide synthetase SWALL:AAK81825 (EMBL:AF386507) (1531 aa) fasta scores: E(): 1.3e-38, 34.02% id in 814 aa, similar in its full length to Agrobacterium tumefaciens StrC58 AGR_l_3476p SWALL:AAK90311 (EMBL:AE008376) (1344 aa) fasta scores: E(): 6.2e-36, 32.96% id in 1338 aa, and N-terminal region similar to the full length of Amycolatopsis orientalis PCZA361.18 SWALL:O52803 (EMBL:AJ223998) (580 aa) fasta scores: E(): 1.3e-33, 38.2% id in 589 aa. C-terminal region presents low similarity database matches to Rhizobium loti (Mesorhizobium loti) peptide synthetase SWALL:Q98JF4 (1325 aa) blastp scores: E(): 3e-13, Identities = 77/327 (23%), Positives = 127/327 (38%); peptide synthase 2059675 2650113 DIP2009 Corynebacterium diphtheriae NCTC 13129 peptide synthase NP_940340.1 2055872 D 257309 CDS NP_940341.1 38234574 2650114 complement(2059672..2065290) 1 NC_002935.2 Similar to Actinomyces viscosus usher-like protein precursor TR:Q9AJ93 (EMBL:AF106034) (1411 aa) fasta scores: E(): 0.034, 22.657% id in 843 aa, and to Actinomyces naeslundii fimbrial associated protein TR:O05995 (EMBL:U85708) (375 aa) fasta scores: E(): 0.14, 25.131% id in 191 aa. Note: Contains a potential sortase anchor site (LPLTG) upstream of the C-terminal region transmembrane domain; surface-anchored membrane protein 2065290 2650114 DIP2010 Corynebacterium diphtheriae NCTC 13129 surface-anchored membrane protein NP_940341.1 2059672 R 257309 CDS NP_940342.1 38234575 2650115 complement(2065294..2065911) 1 NC_002935.2 No significant database matches. Note: Contains a potential sortase anchor site (LAFTG) upstream of the C-terminal region transmembrane domain; surface anchored protein 2065911 2650115 DIP2011 Corynebacterium diphtheriae NCTC 13129 surface anchored protein NP_940342.1 2065294 R 257309 CDS NP_940343.1 38234576 2650116 complement(2065901..2066770) 1 NC_002935.2 Similar to Actinomyces viscosus sortase-like protein SWALL:Q9AJ92 (EMBL:AF106034) (387 aa) fasta scores: E(): 2.7e-39, 43.47% id in 276 aa, and to Bifidobacterium longum NCC2705 sortase-like protein BL0676 SWALL:AAN24497 (EMBL:AE014690) (328 aa) fasta scores: E(): 3.7e-28, 36.94% id in 268 aa, and to Streptococcus pneumoniae sortase, SP0466 SWALL:AAK74626 (EMBL:AE007358) (279 aa) fasta scores: E(): 3e-21, 31.78% id in 258 aa; fimbrial associated sortase-like protein 2066770 2650116 DIP2012 Corynebacterium diphtheriae NCTC 13129 fimbrial associated sortase-like protein NP_940343.1 2065901 R 257309 CDS NP_940344.1 38234577 2650117 complement(2066771..2068348) 1 NC_002935.2 Similar to Actinomyces naeslundii fimbrial subunit type 2 precursor SW:FM2_ACTNA (P12616) (534 aa) fasta scores: E(): 4.4e-20, 28.827% id in 503 aa, and to Actinomyces naeslundii type-1 fimbrial major subunit precursor FimP TR:Q9X4D8 (EMBL:AF107019) (533 aa) fasta scores: E(): 8.5e-15, 27.432% id in 514 aa. Note: Contains a potential sortase anchor site (LPLTG) upstream of the C-terminal region transmembrane domain; surface-anchored fimbrial subunit 2068348 2650117 DIP2013 Corynebacterium diphtheriae NCTC 13129 surface-anchored fimbrial subunit NP_940344.1 2066771 R 257309 CDS NP_940345.1 38234578 2650118 2068581..2069309 1 NC_002935.2 membrane-anchored protein 2069309 2650118 DIP2014 Corynebacterium diphtheriae NCTC 13129 membrane-anchored protein NP_940345.1 2068581 D 257309 CDS NP_940346.1 38234579 2650119 2069482..2070753 1 NC_002935.2 Similar to Streptomyces coelicolor secreted protein SC10G8.24c TR:Q9L181 (EMBL:AL158057) (445 aa) fasta scores: E(): 7.7e-31, 35.363% id in 427 aa, and to Saccharopolyspora spinosa SpnM TR:Q9ALN4 (EMBL:AY007564) (320 aa) fasta scores: E(): 2.2e-23, 36.111% id in 288 aa, and to Candida albicans secretory lipase 5 Lip5 TR:Q9P8W0 (EMBL:AF191318) (463 aa) fasta scores: E(): 2.1e-17, 24.877% id in 406 aa; exported lipase 2070753 2650119 DIP2015 Corynebacterium diphtheriae NCTC 13129 exported lipase NP_940346.1 2069482 D 257309 CDS NP_940347.1 38234580 2650120 complement(2070770..2071666) 1 NC_002935.2 Similar to Pseudomonas aeruginosa hypothetical protein PA0141 SWALL:Q9I6Z1 (EMBL:AE004452) (298 aa) fasta scores: E(): 1.2e-69, 62.06% id in 261 aa, and to Rhizobium loti MLL5641 protein SWALL:Q98BC2 (EMBL:AP003007) (302 aa) fasta scores: E(): 9.2e-57, 49.63% id in 274 aa; hypothetical protein 2071666 2650120 DIP2016 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940347.1 2070770 R 257309 CDS NP_940348.1 38234581 2650121 complement(2071758..2073029) 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical protein ML2321 SWALL:Q9CB79 (EMBL:AL583925) (336 aa) fasta scores: E(): 5.7e-12, 29.15% id in 343 aa; hypothetical protein 2073029 2650121 DIP2017 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940348.1 2071758 R 257309 CDS NP_940349.1 38234582 2650122 complement(2073112..2073252) 1 NC_002935.2 Doubtful CDS. No significant database matches; hypothetical protein 2073252 2650122 DIP2018 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940349.1 2073112 R 257309 CDS NP_940350.1 38234583 2650123 complement(2073342..2073647) 1 NC_002935.2 Similar to Rhizobium loti transposase MLR9644 SWALL:Q98P21 (EMBL:AP003017) (103 aa) fasta scores: E(): 7, 30.58% id in 85 aa; transposase 2073647 2650123 DIP2019 Corynebacterium diphtheriae NCTC 13129 transposase NP_940350.1 2073342 R 257309 CDS NP_940351.1 38234584 2650124 complement(2073868..2075508) 1 NC_002935.2 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 2075508 groEL 2650124 groEL Corynebacterium diphtheriae NCTC 13129 molecular chaperone GroEL NP_940351.1 2073868 R 257309 CDS NP_940352.1 38234585 2650125 complement(2075866..2076036) 1 NC_002935.2 Similar to Corynebacterium jeikeium YkwC SWALL:AAK94053 (EMBL:AF401314) (102 aa) fasta scores: E(): 2.3e-06, 64.28% id in 42 aa; hypothetical protein 2076036 2650125 DIP2021 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940352.1 2075866 R 257309 CDS NP_940353.1 38234586 2650126 complement(2076283..2076546) 1 NC_002935.2 hypothetical protein 2076546 2650126 DIP2022 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940353.1 2076283 R 257309 CDS NP_940354.1 38234587 2650127 2076614..2077324 1 NC_002935.2 Similar to the central domain of Arthrobacter keyseri hypothetical 45.9 kDa protein TnpX SWALL:Q9AGM1 (EMBL:AF331043) (421 aa) fasta scores: E(): 2.1e-12, 35.44% id in 237 aa; hypothetical protein 2077324 2650127 DIP2023 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940354.1 2076614 D 257309 CDS NP_940355.1 38234588 2650128 complement(2077317..2077544) 1 NC_002935.2 hypothetical protein 2077544 2650128 DIP2024 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940355.1 2077317 R 257309 CDS NP_940356.1 38234589 2650129 complement(2077594..2078898) 1 NC_002935.2 Similar to Pseudomonas aeruginosa hypothetical protein PA4583 SWALL:Q9HVK1 (EMBL:AE004872) (404 aa) fasta scores: E(): 7.5e-64, 45.92% id in 405 aa, and to Escherichia coli protein RtcB or B3421 SWALL:RTCB_ECOLI (SWALL:P46850) (408 aa) fasta scores: E(): 6e-45, 46.75% id in 385 aa; hypothetical protein 2078898 2650129 DIP2025 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940356.1 2077594 R 257309 CDS NP_940357.1 38234590 2650131 complement(2080479..2081561) 1 NC_002935.2 Similar to Xylella fastidiosa NAD(P)H-dependent 2-cyclohexen-1-one reductase XF1732 SWALL:Q9PCP6 (EMBL:AE003996) (368 aa) fasta scores: E(): 1.3e-62, 50.56% id in 356 aa, and to Pseudomonas syringae NAD(P)H-dependent 2-cyclohexen-1-one reductase Ncr SWALL:Q9Z3T1 (EMBL:AF093246) (360 aa) fasta scores: E(): 4e-45, 40.54% id in 365 aa; NAD(P)H-dependent reductase 2081561 2650131 DIP2030 Corynebacterium diphtheriae NCTC 13129 NAD(P)H-dependent reductase NP_940357.1 2080479 R 257309 CDS NP_940358.1 38234591 2650132 2081863..2084454 1 NC_002935.2 Similar to Pseudomonas lemoignei excinuclease ABC subunit A UvrA SWALL:UVRA_PSELE (SWALL:P52087) (689 aa) fasta scores: E(): 1.1e-73, 60.02% id in 703 aa, and to Micrococcus luteus excinuclease ABC subunit A UvrA SWALL:UVRA_MICLU (SWALL:P13567) (992 aa) fasta scores: E(): 8.7e-50, 38.63% id in 1012 aa, and to Streptomyces coelicolor excinuclease ABC subunit A Uvra or SCC54.18c SWALL:UVRA_STRCO (SWALL:Q9Z507) (1014 aa) fasta scores: E(): 2.8e-49, 39.67% id in 993 aa; excinuclease ABC subunit A 2084454 uvrA2 2650132 uvrA2 Corynebacterium diphtheriae NCTC 13129 excinuclease ABC subunit A NP_940358.1 2081863 D 257309 CDS NP_940359.1 38234592 2650133 2084696..2085232 1 NC_002935.2 Similar to Pseudomonas aeruginosa probable protease PA4171 SWALL:Q9HWL0 (EMBL:AE004833) (187 aa) fasta scores: E(): 3.2e-25, 50.28% id in 175 aa, and to Pyrococcus furiosus protease I PfpI or PF1719 SWALL:PFPI_PYRFU (SWALL:Q51732) (166 aa) fasta scores: E(): 1.8e-19, 40.58% id in 170 aa; protease 2085232 2650133 DIP2032 Corynebacterium diphtheriae NCTC 13129 protease NP_940359.1 2084696 D 257309 CDS NP_940360.1 38234593 2650134 complement(2085350..2085481) 1 NC_002935.2 Similar partially to the C-terminal region of Saccharopolyspora sp transposase SapX SWALL:O52713 (EMBL:AF045021) (103 aa) fasta scores: E(): 1.3e-06, 58.53% id in 41 aa, and to Mycobacterium tuberculosis insertion element IS986 hypothetical 6.6 kDa protein SWALL:YIA2_MYCTU (SWALL:P19772) (59 aa) fasta scores: E(): 9.5e-05, 60% id in 35 aa; transposase 2085481 2650134 DIP2033 Corynebacterium diphtheriae NCTC 13129 transposase NP_940360.1 2085350 R 257309 CDS NP_940361.1 38234594 2650136 2086286..2086948 1 NC_002935.2 hypothetical protein 2086948 2650136 DIP2036 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940361.1 2086286 D 257309 CDS NP_940362.1 38234595 2650137 2087440..2088801 1 NC_002935.2 Similar to Streptomyces coelicolor peptidase SCG22.20 SWALL:Q9K425 (EMBL:AL359779) (451 aa) fasta scores: E(): 5.7e-70, 44.19% id in 448 aa, and to Mycobacterium leprae hypothetical 46.6 kDa protein ML1193 or MLCB458.08 SWALL:Q9X7E4 (EMBL:AL049478) (442 aa) fasta scores: E(): 1.1e-52, 37.41% id in 441 aa; hypothetical protein 2088801 2650137 DIP2037 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940362.1 2087440 D 257309 CDS NP_940363.1 38234596 2650138 2088814..2089029 1 NC_002935.2 Doubtful CDS. No strong consensus RBS usptream. No significant database matches; hypothetical protein 2089029 2650138 DIP2038 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940363.1 2088814 D 257309 CDS NP_940364.1 38234597 2650139 2089037..2089327 1 NC_002935.2 hypothetical protein 2089327 2650139 DIP2039 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940364.1 2089037 D 257309 CDS NP_940365.1 38234598 2650140 2089327..2090487 1 NC_002935.2 Similar to Mycobacterium leprae probable conserved membrane protein ML1504 SWALL:Q9CBX0 (EMBL:AL583922) (430 aa) fasta scores: E(): 1.8e-10, 31.8% id in 349 aa, and to Mycobacterium tuberculosis hypothetical 47.1 kDa protein Rv1159 or MT1195 or MTCI65.26 SWALL:O06557 (EMBL:Z95584) (431 aa) fasta scores: E(): 4.3e-10, 31.66% id in 360 aa; hypothetical protein 2090487 2650140 DIP2040 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940365.1 2089327 D 257309 CDS NP_940366.1 38234599 2650141 complement(2090430..2091509) 1 NC_002935.2 ATP-dependent carboxylate-amine ligase; carboxylate-amine ligase 2091509 2650141 DIP2042 Corynebacterium diphtheriae NCTC 13129 carboxylate-amine ligase NP_940366.1 2090430 R 257309 CDS NP_940367.1 38234600 2650142 complement(2091506..2092039) 1 NC_002935.2 hypothetical protein 2092039 2650142 DIP2043 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940367.1 2091506 R 257309 CDS NP_940368.1 38234601 2650143 complement(2092042..2092245) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 9.6 kDa protein SCD95A.20 SWALL:Q9KXV4 (EMBL:AL357432) (84 aa) fasta scores: E(): 1e-08, 54.09% id in 61 aa, and to Mycobacterium tuberculosis hypothetical 11.7 kDa protein Rv0430 or MT0445 or MTCY22G10.27 SWALL:P96276 (EMBL:Z84724) (102 aa) fasta scores: E(): 2.2e-07, 48.38% id in 62 aa; hypothetical protein 2092245 2650143 DIP2044 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940368.1 2092042 R 257309 CDS NP_940369.1 38234602 2650144 2092244..2092807 1 NC_002935.2 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 2092807 def 2650144 def Corynebacterium diphtheriae NCTC 13129 peptide deformylase NP_940369.1 2092244 D 257309 CDS NP_940370.1 38234603 2650145 2092824..2093711 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 32.6 kDa protein Rv0428c or MT0443 or MTCY22G10.25c SWALL:P96274 (EMBL:Z84724) (302 aa) fasta scores: E(): 2.7e-22, 34.53% id in 304 aa, and to Caulobacter crescentus acetyltransferase, GNAT family CC2209 SWALL:Q9A685 (EMBL:AE005892) (207 aa) fasta scores: E(): 2.4e-06, 30.76% id in 208 aa; hypothetical protein 2093711 2650145 DIP2046 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940370.1 2092824 D 257309 CDS NP_940371.1 38234604 2650146 2093716..2094423 1 NC_002935.2 Similar to Streptomyces coelicolor exonuclease SC3A7.09 SWALL:O86610 (EMBL:AL031155) (259 aa) fasta scores: E(): 4.4e-32, 51.93% id in 258 aa, and to Mycobacterium tuberculosis CDC1551 exodeoxyribonuclease III MT0442 SWALL:AAK44665 (EMBL:AE006947) (291 aa) fasta scores: E(): 1.2e-25, 54.16% id in 264 aa; exonuclease 2094423 2650146 DIP2047 Corynebacterium diphtheriae NCTC 13129 exonuclease NP_940371.1 2093716 D 257309 CDS NP_940372.1 38234605 2650147 2094420..2095853 1 NC_002935.2 Similar to Xylella fastidiosa cardiolipin synthase XF1209 SWALL:Q9PE19 (EMBL:AE003954) (467 aa) fasta scores: E(): 3.2e-52, 35.02% id in 474 aa, and to Bacillus firmus cardiolipin synthetase Cls SWALL:CLS_BACFI (SWALL:O66043) (503 aa) fasta scores: E(): 3.4e-41, 30.56% id in 494 aa, and to Escherichia coli cardiolipin synthetase Cls or Nov or B1249 SWALL:CLS_ECOLI (SWALL:P31071) (486 aa) fasta scores: E(): 2.6e-37, 27.18% id in 493 aa; cardiolipin synthase 2095853 2650147 DIP2048 Corynebacterium diphtheriae NCTC 13129 cardiolipin synthase NP_940372.1 2094420 D 257309 CDS NP_940373.1 38234606 2650148 complement(2096446..2097183) 1 NC_002935.2 Low similarity to Streptomyces coelicolor ABC transporter integral membrane protein SCE8.16c SWALL:Q9Z4W1 (EMBL:AL035654) (264 aa) fasta scores: E(): 1.7e-09, 26.37% id in 254 aa; ABC transporter 2097183 2650148 DIP2049 Corynebacterium diphtheriae NCTC 13129 ABC transporter NP_940373.1 2096446 R 257309 CDS NP_940374.1 38234607 2650149 complement(2097167..2098096) 1 NC_002935.2 Similar to Streptomyces coelicolor ABC transporter ATP-binding subunit 2SC6G5.39c SWALL:Q9K4B6 (EMBL:AL359152) (346 aa) fasta scores: E(): 9.3e-56, 60% id in 305 aa, and to Bacillus sphaericus CDD4-like protein SWALL:Q9Z5R0 (EMBL:AJ224479) (311 aa) fasta scores: E(): 7.9e-29, 37.45% id in 299 aa; ABC transporter ATP-binding protein 2098096 2650149 DIP2050 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_940374.1 2097167 R 257309 CDS NP_940375.1 38234608 2650150 2098098..2099354 1 NC_002935.2 Similar to Mycobacterium leprae membrane protein MLCB1450.21c SWALL:Q9ZBL6 (EMBL:AL035159) (403 aa) fasta scores: E(): 3.4e-22, 32.51% id in 406 aa, and to Mycobacterium tuberculosis hypothetical 47.1 kDa protein Rv0412c or MT0425 or MTCY22G10.08c SWALL:AAK44649 (EMBL:Z84724) (439 aa) fasta scores: E(): 3.1e-21, 33.09% id in 414 aa; hypothetical protein 2099354 2650150 DIP2051 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940375.1 2098098 D 257309 CDS NP_940376.1 38234609 2650151 2099351..2100298 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 amino acid ABC transporter, amino acid-binding protein MT0424 SWALL:AAK44648 (EMBL:AE006946) (328 aa) fasta scores: E(): 1.5e-33, 41.84% id in 325 aa, and to Bacillus stearothermophilus glutamine-binding protein precursor GlnH SWALL:GLNH_BACST (SWALL:P27676) (262 aa) fasta scores: E(): 5.3e-19, 31.25% id in 240 aa; ABC transporter 2100298 2650151 DIP2052 Corynebacterium diphtheriae NCTC 13129 ABC transporter NP_940376.1 2099351 D 257309 CDS NP_940377.1 38234610 2650152 2100295..2102457 1 NC_002935.2 Similar to Mycobacterium tuberculosis probable serine/threonine-protein kinase PknG or Rv0410c or MT0423 or MTCY22G10.06c SWALL:PKNG_MYCTU (SWALL:P96256) (750 aa) fasta scores: E(): 2.8e-52, 44.97% id in 656 aa, and to Mycobacterium tuberculosis probable serine/threonine-protein kinase PknL or Rv2176 or MT2232 or MTV021.09 SWALL:PKNL_MYCTU (SWALL:O53510) (399 aa) fasta scores: E(): 4e-06, 28.61% id in 318 aa; protein kinase 2102457 2650152 DIP2053 Corynebacterium diphtheriae NCTC 13129 protein kinase NP_940377.1 2100295 D 257309 CDS NP_940378.1 38234611 2650153 complement(2102477..2103676) 1 NC_002935.2 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2103676 ackA 2650153 ackA Corynebacterium diphtheriae NCTC 13129 acetate kinase NP_940378.1 2102477 R 257309 CDS NP_940379.1 38234612 2650154 complement(2103677..2105128) 1 NC_002935.2 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 2105128 eutD 2650154 eutD Corynebacterium diphtheriae NCTC 13129 phosphotransacetylase NP_940379.1 2103677 R 257309 CDS NP_940380.1 38234613 2650155 2105308..2106666 1 NC_002935.2 Similar to Streptomyces coelicolor ferredoxin/ferredoxin-NADP reductase SCF15.02 SWALL:Q9RK35 (EMBL:AL132856) (454 aa) fasta scores: E(): 4e-107, 59.95% id in 452 aa, and to Rattus norvegicus NADPH:adrenodoxin oxidoreductase, mitochondrial precursor FdxR SWALL:ADRO_RAT (SWALL:P56522) (494 aa) fasta scores: E(): 1.3e-42, 36.02% id in 458 aa, and to Mycobacterium tuberculosis probable ferredoxin/ferredoxin--NADP reductase FprB or Rv0886 or MT0909 or MTCY31.14 SWALL:FPRB_MYCTU (SWALL:Q10547) (575 aa) fasta scores: E(): 2.1e-33, 35.98% id in 453 aa; ferredoxin/ferredoxin-NADP reductase 2106666 2650155 DIP2056 Corynebacterium diphtheriae NCTC 13129 ferredoxin/ferredoxin-NADP reductase NP_940380.1 2105308 D 257309 CDS NP_940381.1 38234614 2650156 complement(2106678..2107574) 1 NC_002935.2 Similar to although shorter in its N-terminal region than Pasteurella haemolytica probable phosphoribosylglycinamide formyltransferase 2 PurT or Mpa1 SWALL:PURT_PASHA (SWALL:P46927) (392 aa) fasta scores: E(): 1e-12, 32.24% id in 276 aa, than Bacillus subtilis phosphoribosylglycinamide formyltransferase 2 PurT SWALL:PURT_BACSU (SWALL:P39771) (384 aa) fasta scores: E(): 3.8e-12, 35.81% id in 282 aa, and than Escherichia coli phosphoribosylglycinamide formyltransferase 2 PurT or B1849 SWALL:PURT_ECOLI (SWALL:P33221) (391 aa) fasta scores: E(): 1.2e-09, 29.82% id in 285 aa; phosphoribosylglycinamide formyltransferase 2107574 2650156 DIP2057 Corynebacterium diphtheriae NCTC 13129 phosphoribosylglycinamide formyltransferase NP_940381.1 2106678 R 257309 CDS NP_940382.1 38234615 2650157 2107606..2108106 1 NC_002935.2 Similar to Streptomyces coelicolor purine phosphoribosyltransferase SCH35.47 SWALL:Q9X8V9 (EMBL:AL078610) (165 aa) fasta scores: E(): 1.1e-27, 52.25% id in 155 aa, and to Aeropyrum pernix 272aa long hypothetical hypoxanthine phosphoribosyltransferase APE2071 SWALL:Q9YA68 (EMBL:AP000063) (272 aa) fasta scores: E(): 3.8e-16, 36.47% id in 159 aa; purine phosphoribosyltransferase 2108106 2650157 DIP2058 Corynebacterium diphtheriae NCTC 13129 purine phosphoribosyltransferase NP_940382.1 2107606 D 257309 CDS NP_940383.1 38234616 2650158 2108231..2109025 1 NC_002935.2 No significant database matches. Note: Also similar to DIP0167 (259 aa) E(): 4.6e-41; 44.747% identity in 257 aa overlap; hypothetical protein 2109025 2650158 DIP2059 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940383.1 2108231 D 257309 CDS NP_940384.1 38234617 2650159 complement(2109022..2110452) 1 NC_002935.2 Low similarity to Campylobacter jejuni membrane protein CjaE SWALL:Q9RM70 (EMBL:AJ249744) (505 aa) fasta scores: E(): 3.1e-24, 28.45% id in 471 aa; hypothetical protein 2110452 2650159 DIP2060 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940384.1 2109022 R 257309 CDS NP_940385.1 38234618 2650160 complement(2110453..2110620) 1 NC_002935.2 Similar to Helicobacter pylori hypothetical 6.1 kDa protein HP0594 SWALL:O25316 (EMBL:AE000573) (54 aa) fasta scores: E(): 0.026, 32.72% id in 55 aa, and to Campylobacter jejuni small hydrophobic protein CJ0018c SWALL:Q9PJ93 (EMBL:AL139074) (55 aa) fasta scores: E(): 0.046, 35.71% id in 56 aa. Note: Highly hydrophobic; hypothetical protein 2110620 2650160 DIP2061 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940385.1 2110453 R 257309 CDS NP_940386.1 38234619 2650161 complement(2111093..2112964) 1 NC_002935.2 Low similarity to Streptococcus agalactiae BPS protein precursor Sar5 TR:Q9XAS7 (EMBL:AJ133114) (979 aa) fasta scores: E(): 7.1e-12, 32.35% id in 442 aa, and to Staphylococcus epidermidis cell-surface adhesin SdrF TR:Q9KI14 (EMBL:AF245041) (1733 aa) fasta scores: E(): 0.015, 24.86% id in 539 aa. Note: Contains a potential sortase anchor site (LAATG) upstream of the C-terminal region transmembrane domain; surface anchored protein 2112964 2650161 DIP2062 Corynebacterium diphtheriae NCTC 13129 surface anchored protein NP_940386.1 2111093 R 257309 CDS NP_940387.1 38234620 2650162 complement(2113380..2114669) 1 NC_002935.2 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 2114669 purA 2650162 purA Corynebacterium diphtheriae NCTC 13129 adenylosuccinate synthetase NP_940387.1 2113380 R 257309 CDS NP_940388.1 38234621 2650163 2114764..2114973 1 NC_002935.2 Similar to part of several beta-ketoacyl-ACP synthases e.g. Streptomyces coelicolor actinorhodin polyketide beta-ketoacyl synthase 1 SW:KASA_STRCO (Q02059) (424 aa) fasta scores: E(): 2.1, 31.343% id in 67 aa, and to Arabidopsis thaliana 3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplast precursor Kas1 SW:FABB_ARATH (P52410) (473 aa) fasta scores: E(): 5.8, 27.273% id in 77 aa; beta-ketoacyl-ACP synthase gene remnant 2114973 2650163 DIP2064 Corynebacterium diphtheriae NCTC 13129 beta-ketoacyl-ACP synthase gene remnant NP_940388.1 2114764 D 257309 CDS NP_940389.1 38234622 2650164 2115398..2115535 1 NC_002935.2 Similar to part of several hyrolases e.g. Rhodococcus globerulus 2-hydroxy-6-ketonona-2,4-dienoate hydrolase HppC TR:O05145 (EMBL:U89712) (288 aa) fasta scores: E(): 3.9e-15, 80.000% id in 45 aa, and to Pseudomonas putida 2-hydroxymuconic semialdehyde hydrolase XylF SW:XYLF_PSEPU (P23106) (281 aa) fasta scores: E(): 0.00093, 41.667% id in 36 aa; hydrolase gene remnant 2115535 2650164 DIP2065 Corynebacterium diphtheriae NCTC 13129 hydrolase gene remnant NP_940389.1 2115398 D 257309 CDS NP_940390.1 38234623 2650165 2115840..2119082 1 NC_002935.2 Some similarity to Actinomyces naeslundii fimbrial associated protein TR:O05995 (EMBL:U85708) (375 aa) fasta scores: E(): 0.0012, 28.803% id in 309 aa. Note: Contains a potential sortase anchor site (LPKTG) upstream of the C-terminal region transmembrane domain; surface-anchored fimbrial associated protein 2119082 2650165 DIP2066 Corynebacterium diphtheriae NCTC 13129 surface-anchored fimbrial associated protein NP_940390.1 2115840 D 257309 CDS NP_940391.1 38234624 2650166 2119377..2120108 1 NC_002935.2 Similar to Mycobacterium leprae hypothetical 25.3 kDa protein ML0281 or MLCB4.24 SWALL:O69596 (EMBL:AL023514) (229 aa) fasta scores: E(): 6.1e-08, 36.63% id in 202 aa; hypothetical protein 2120108 2650166 DIP2067 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940391.1 2119377 D 257309 CDS NP_940392.1 38234625 2650167 complement(2120105..2121232) 1 NC_002935.2 Similar to Corynebacterium glutamicum hypothetical protein in fda 3'region SWALL:YFDA_CORGL (SWALL:Q99340) (359 aa) fasta scores: E(): 4.8e-63, 51.61% id in 341 aa, and to Mycobacterium tuberculosis hypothetical 36.8 kDa protein Rv2571c or MT2647 or MTCY227.30 SWALL:YP71_MYCTU (SWALL:Q50650) (355 aa) fasta scores: E(): 1.1e-12, 25.07% id in 331 aa. Note: Also similar to DIP2070 (393 aa) E(): 8.6e-66; 52.174% identity in 368 aa overlap; hypothetical protein 2121232 2650167 DIP2068 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940392.1 2120105 R 257309 CDS NP_940393.1 38234626 2650168 2121346..2122479 1 NC_002935.2 hypothetical protein 2122479 2650168 DIP2069 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940393.1 2121346 D 257309 CDS NP_940394.1 38234627 2650169 complement(2122571..2123752) 1 NC_002935.2 Similar to Corynebacterium glutamicum hypothetical protein in fda 3'region SWALL:YFDA_CORGL (SWALL:Q99340) (359 aa) fasta scores: E(): 8.6e-62, 48.97% id in 341 aa, and to Mycobacterium tuberculosis hypothetical 36.8 kDa protein Rv2571c or MT2647 or MTCY227.30 SWALL:YP71_MYCTU (SWALL:Q50650) (355 aa) fasta scores: E(): 3.6e-12, 28.2% id in 234 aa. Note: Also similar to DIP2068 (375 aa) E(): 8.4e-62; 52.174% identity in 368 aa overlap; hypothetical protein 2123752 2650169 DIP2070 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940394.1 2122571 R 257309 CDS NP_940395.1 38234628 2650170 2124164..2125075 1 NC_002935.2 hypothetical protein 2125075 2650170 DIP2071 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940395.1 2124164 D 257309 CDS NP_940396.1 38234629 2650171 2125361..2126473 1 NC_002935.2 hypothetical protein 2126473 2650171 DIP2072 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940396.1 2125361 D 257309 CDS NP_940397.1 38234630 2650172 2126517..2127308 1 NC_002935.2 hypothetical protein 2127308 2650172 DIP2073 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940397.1 2126517 D 257309 CDS NP_940398.1 38234631 2650173 2127573..2127881 1 NC_002935.2 Similar to Escherichia coli Hp2 or InsA SWALL:O87507 (EMBL:AF081284) (100 aa) fasta scores: E(): 8.6e-07, 31.95% id in 97 aa, and to Shigella flexneri TnpJ or S0170 or S0109 SWALL:Q9XCG9 (EMBL:AF141323) (100 aa) fasta scores: E(): 8.6e-07, 31.95% id in 97 aa, and to Shigella dysenteriae InsA SWALL:Q9LA21 (EMBL:AF153317) (100 aa) fasta scores: E(): 2.1e-06, 31.95% id in 97 aa; tranposase 2127881 2650173 DIP2074 Corynebacterium diphtheriae NCTC 13129 tranposase NP_940398.1 2127573 D 257309 CDS NP_940399.1 38234632 2650174 complement(2127929..2128273) 1 NC_002935.2 hypothetical protein 2128273 2650174 DIP2075 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940399.1 2127929 R 257309 CDS NP_940400.1 38234633 2650175 2128362..2128724 1 NC_002935.2 hypothetical protein 2128724 2650175 DIP2076 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940400.1 2128362 D 257309 CDS NP_940401.1 38234634 2650176 2128744..2128917 1 NC_002935.2 hypothetical protein 2128917 2650176 DIP2077 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940401.1 2128744 D 257309 CDS NP_940402.1 38234635 2650177 complement(2128919..2129182) 1 NC_002935.2 hypothetical protein 2129182 2650177 DIP2077A Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940402.1 2128919 R 257309 CDS NP_940403.1 38234636 2650178 complement(2129194..2130531) 1 NC_002935.2 member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; inner membrane permease YgbN 2130531 2650178 DIP2078 Corynebacterium diphtheriae NCTC 13129 inner membrane permease YgbN NP_940403.1 2129194 R 257309 CDS NP_940404.1 38234637 2650179 complement(2130534..2131430) 1 NC_002935.2 Similar to many oxidoreductases e.g. Rhizobium meliloti oxidoreductase R01702 or SMC00274 SWALL:CAC46281 (EMBL:AL591788) (295 aa) fasta scores: E(): 7.6e-30, 41.4% id in 285 aa, and to Escherichia coli hypothetical oxidoreductase YgbJ or B2736 SWALL:YGBJ_ECOLI (SWALL:Q46888) (302 aa) fasta scores: E(): 2e-26, 36.08% id in 291 aa; oxidoreductase 2131430 2650179 DIP2079 Corynebacterium diphtheriae NCTC 13129 oxidoreductase NP_940404.1 2130534 R 257309 CDS NP_940405.1 38234638 2649551 complement(2131499..2132950) 1 NC_002935.2 Similar to Synechocystis sp hypothetical 48.5 kDa protein SLR1342 SWALL:P74079 (EMBL:D90912) (445 aa) fasta scores: E(): 2.4e-39, 34.19% id in 462 aa; hypothetical protein 2132950 2649551 DIP2080 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940405.1 2131499 R 257309 CDS NP_940406.1 38234639 2649552 complement(2133153..2133851) 1 NC_002935.2 Similar to Escherichia coli O157:H7 transcriptional regulator LldR or Z5031 or ECS4482 SWALL:BAB37905 (EMBL:AE005588) (258 aa) fasta scores: E(): 1.9e-14, 33.48% id in 224 aa, and to Pseudomonas aeruginosa transcriptional regulator GlcC or PA5356 SWALL:Q9HTK2 (EMBL:AE004947) (251 aa) fasta scores: E(): 1e-13, 32.36% id in 241 aa; transcriptional regulator 2133851 2649552 DIP2081 Corynebacterium diphtheriae NCTC 13129 transcriptional regulator NP_940406.1 2133153 R 257309 CDS NP_940407.1 38234640 2649554 2135858..2137066 1 NC_002935.2 Similar to Streptomyces coelicolor insertion element IS110 hypothetical 43.6 kDa protein SC3C8.10 and SCC57A.30c and SCG2.18 and SC5E9.30 SWALL:YIS1_STRCO (SWALL:P19780) (405 aa) fasta scores: E(): 1.6e-52, 40.65% id in 396 aa, and to Shigella flexneri transposase for IS110 s0128 SWALL:Q9AFS5 (EMBL:AF348706) (398 aa) fasta scores: E(): 1.5e-47, 42.44% id in 384 aa; transposase for insertion element 2137066 2649554 DIP2083 Corynebacterium diphtheriae NCTC 13129 transposase for insertion element NP_940407.1 2135858 D 257309 CDS NP_940408.1 38234641 2649556 2138047..2138529 1 NC_002935.2 Similar to Streptococcus pneumoniae hypothetical 20.7 kDa protein SWALL:Q9KK22 (EMBL:AF154034) (171 aa) fasta scores: E(): 3.2e-09, 33.54% id in 155 aa, and to Escherichia coli insertion element IS1397 hypothetical 20.1 kDa protein SWALL:YI9A_ECOLI (SWALL:Q47309) (173 aa) fasta scores: E(): 0.0075, 33.62% id in 113 aa; insertion element 2138529 2649556 DIP2085 Corynebacterium diphtheriae NCTC 13129 insertion element NP_940408.1 2138047 D 257309 CDS NP_940409.1 38234642 2649560 2141760..2144615 1 NC_002935.2 Low similarity to Staphylococcus aureus (strain N315) Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein SdrC or SA0519 or SAV0561 SWALL:BAB56723 (EMBL:AP003131) (953 aa) fasta scores: E(): 4.5e-06, 28.57% id in 448 aa, and to Staphylococcus aureus SdrC protein SWALL:O86487 (EMBL:AJ005645) (947 aa) fasta scores: E(): 1.6e-05, 25% id in 804 aa. Note: There is no similarity to the C-terminal SD rich region of the database hits and contains a potential sortase anchor site (LAATG) upstream of the C-terminal region transmembrane domain; Sdr family related adhesin 2144615 2649560 DIP2093 Corynebacterium diphtheriae NCTC 13129 Sdr family related adhesin NP_940409.1 2141760 D 257309 CDS NP_940410.1 38234643 2649561 complement(2144833..2145867) 1 NC_002935.2 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 2145867 fba 2649561 fba Corynebacterium diphtheriae NCTC 13129 fructose-bisphosphate aldolase NP_940410.1 2144833 R 257309 CDS NP_940411.1 38234644 2649562 complement(2145986..2147113) 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 fructose-bisphosphate aldolase MT0381 SWALL:AAK44602 (EMBL:AE006943) (376 aa) fasta scores: E(): 7.2e-55, 43.61% id in 376 aa, and to Corynebacterium glutamicum hypothetical protein in fda 5' region SWALL:Q99336 (EMBL:X17313) (304 aa) fasta scores: E(): 1.6e-37, 60.55% id in 289 aa; hypothetical protein 2147113 2649562 DIP2095 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940411.1 2145986 R 257309 CDS NP_940412.1 38234645 2649563 complement(2147125..2147643) 1 NC_002935.2 Similar to although shoter in its N-terminal region than Mycobacterium tuberculosis CDC1551 SpoU rRNA methylase MT0393 SWALL:AAK44615 (EMBL:AE006944) (183 aa) fasta scores: E(): 6.2e-51, 74.41% id in 172 aa, and to Escherichia coli tRNA TrmH or SpoU or B3651 or Z5077 or ECS4526 SWALL:TRMH_ECOLI (SWALL:P19396) (229 aa) fasta scores: E(): 4.6e-07, 28.94% id in 152 aa; RNA methylase 2147643 2649563 DIP2096 Corynebacterium diphtheriae NCTC 13129 RNA methylase NP_940412.1 2147125 R 257309 CDS NP_940413.1 38234646 2649564 complement(2147786..2148319) 1 NC_002935.2 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 2148319 pyrE 2649564 pyrE Corynebacterium diphtheriae NCTC 13129 orotate phosphoribosyltransferase NP_940413.1 2147786 R 257309 CDS NP_940414.1 38234647 2649565 complement(2148375..2149289) 1 NC_002935.2 hypothetical protein 2149289 2649565 DIP2098 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940414.1 2148375 R 257309 CDS NP_940415.1 38234648 2649566 complement(2149289..2150113) 1 NC_002935.2 Similar to Streptomyces coelicolor thiosulfate sulfurtransferase SC9B10.21 SWALL:O50528 (EMBL:AL009204) (283 aa) fasta scores: E(): 1.8e-28, 35% id in 280 aa, and to Pseudomonas aeruginosa probable 3-mercaptopyruvate sulfurtransferase SseA or PA1292 SWALL:THTM_PSEAE (SWALL:Q9I452) (284 aa) fasta scores: E(): 2.4e-28, 36.07% id in 280 aa; sulfultransferase 2150113 2649566 DIP2099 Corynebacterium diphtheriae NCTC 13129 sulfultransferase NP_940415.1 2149289 R 257309 CDS NP_940416.1 38234649 2649567 complement(2150259..2150489) 1 NC_002935.2 hypothetical protein 2150489 2649567 DIP2100 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940416.1 2150259 R 257309 CDS NP_940417.1 38234650 2649568 complement(2150689..2150889) 1 NC_002935.2 Similar to Corynebacterium glutamicum ClpB protein SWALL:CLPB_CORGL (SWALL:P53532) (852 aa) fasta scores: E(): 0.027, 44.44% id in 99 aa, and to Mycobacterium leprae heat shock protein ClpB or ML2490 SWALL:Q9CB26 (EMBL:AL583925) (848 aa) fasta scores: E(): 0.66, 35.41% id in 96 aa. Note: Similar also to the C-terminal part of DIP2104 (849 aa) E(): 7.2e-08; 53.465% identity in 101 aa overlap; heat shock protein (partial) 2150889 clpB2 2649568 clpB2 Corynebacterium diphtheriae NCTC 13129 heat shock protein (partial) NP_940417.1 2150689 R 257309 CDS NP_940418.1 38234651 2649569 complement(2151027..2151551) 1 NC_002935.2 hypothetical protein 2151551 2649569 DIP2102 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940418.1 2151027 R 257309 CDS NP_940419.1 38234652 2649570 complement(2151552..2151704) 1 NC_002935.2 hypothetical protein 2151704 2649570 DIP2103 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940419.1 2151552 R 257309 CDS NP_940420.1 38234653 2649571 complement(2151849..2154398) 1 NC_002935.2 Similar to Escherichia coli ClpB or HtpM or B2592 or Z3886 or ECS3455 SW:CLPB_ECOLI (P03815) (857 aa) fasta scores: E(): 2.3e-133, 56.67% id in 847 aa, and to Corynebacterium glutamicum ClpB SW:CLPB_CORGL (P53532) (852 aa) fasta scores: E(): 0, 85.25% id in 841 aa; ATP-dependent protease regulatory subunit, ClpB 2154398 clpB 2649571 clpB Corynebacterium diphtheriae NCTC 13129 ATP-dependent protease regulatory subunit, ClpB NP_940420.1 2151849 R 257309 CDS NP_940421.1 38234654 2649572 complement(2154597..2154926) 1 NC_002935.2 Similar to the N-terminal portion of many from actinomycetes eg. Streptomyces coelicolor secreted protein SCE41.06c TR:Q9F2Q2 (EMBL:AL442120) (244 aa) fasta scores: E(): 7.5e-21, 65.74% id in 108 aa. Also full length similarity to others from actinomycetes eg. Streptomyces coelicolor membrane protein SC5C11.15 TR:Q9L157 (EMBL:AL158060) (121 aa) fasta scores: E(): 1.9e-14, 50.49% id in 101 aa; hypothetical protein 2154926 2649572 DIP2105 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940421.1 2154597 R 257309 CDS NP_940422.1 38234655 2649573 2155054..2155842 1 NC_002935.2 Similar to Streptomyces coelicolor ABC transport system ATP-binding protein SCD10.29c TR:Q9K3U8 (EMBL:AL359988) (263 aa) fasta scores: E(): 8.8e-37, 49.6% id in 252 aa, and to Caulobacter crescentus ABC transporter, ATP-binding protein CC0838 TR:Q9A9X3 (EMBL:AE005760) (250 aa) fasta scores: E(): 2.6e-27, 42.25% id in 239 aa; ABC transporter ATP-binding protein 2155842 2649573 DIP2106 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_940422.1 2155054 D 257309 CDS NP_940423.1 38234656 2649574 2155844..2157412 1 NC_002935.2 Similar to Streptomyces coelicolor integral membrane transport protein SCD10.28c TR:Q9K3U9 (EMBL:AL359988) (550 aa) fasta scores: E(): 6.2e-18, 25.27% id in 542 aa. Lies alongside a ABC transporter ATP-binding subunit; integral membrane transport protein 2157412 2649574 DIP2107 Corynebacterium diphtheriae NCTC 13129 integral membrane transport protein NP_940423.1 2155844 D 257309 CDS NP_940424.1 38234657 2649575 complement(2157906..2159243) 1 NC_002935.2 Weakly similar to many eg. Pseudomonas aeruginosa sodium/glutamate symporter GltS or PA3176 TR:Q9HZ58 (EMBL:AE004741) (404 aa) fasta scores: E(): 2.2e-06, 23.83% id in 365 aa, and to Escherichia coli sodium/glutamate symport carrier protein GltS or GltC or B3653 SW:GLTS_ECOLI (P19933) (401 aa) fasta scores: E(): 0.097, 22.36% id in 398 aa; hypothetical protein 2159243 2649575 DIP2108 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940424.1 2157906 R 257309 CDS NP_940425.1 38234658 2649576 complement(2159370..2160410) 1 NC_002935.2 Similar to Rhizobium loti MLL2462 protein TR:Q98IC8 (EMBL:AP002999) (352 aa) fasta scores: E(): 1.7e-36, 37.16% id in 339 aa; integral membrane protein 2160410 2649576 DIP2109 Corynebacterium diphtheriae NCTC 13129 integral membrane protein NP_940425.1 2159370 R 257309 CDS NP_940426.1 38234659 2649577 2160416..2161519 1 NC_002935.2 Similar to Mycobacterium bovis 47 kDa protein Rv0385 or MT0398 or MTV036.20 TR:O86363 (EMBL:U73653) (390 aa) fasta scores: E(): 4.7e-29, 36.36% id in 352 aa, and to Acinetobacter calcoaceticus phenolhydroxylase component TR:Q43983 (EMBL:Z36909) (350 aa) fasta scores: E(): 2.2e-06, 25.61% id in 246 aa, and to Pseudomonas sp phenol hydroxylase P5 protein DmpP SW:DMPP_PSESP (P19734) (352 aa) fasta scores: E(): 8.3e-06, 24.3% id in 251 aa; hypothetical protein 2161519 2649577 DIP2110 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940426.1 2160416 D 257309 CDS NP_940427.1 38234660 2649578 complement(2161498..2162268) 1 NC_002935.2 Similar to Mycobacterium leprae hydrolase ML2449 TR:Q9CB47 (EMBL:AL583925) (271 aa) fasta scores: E(): 4.8e-37, 47.84% id in 255 aa, and to Mus musculus Nit protein 2 or 1190017B19riK TR:Q9JHW2 (EMBL:AF284573) (276 aa) fasta scores: E(): 2.7e-17, 29.88% id in 251 aa; hydrolase 2162268 2649578 DIP2111 Corynebacterium diphtheriae NCTC 13129 hydrolase NP_940427.1 2161498 R 257309 CDS NP_940428.1 38234661 2649579 complement(2162322..2162480) 1 NC_002935.2 Doubtful CDS. No significant database matches. No stong consensus RBS. Predicted by Frameplot; hypothetical protein 2162480 2649579 DIP2112 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940428.1 2162322 R 257309 CDS NP_940429.1 38234662 2649580 2162652..2163782 1 NC_002935.2 hypothetical protein 2163782 2649580 DIP2113 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940429.1 2162652 D 257309 CDS NP_940430.1 38234663 2649581 complement(2163769..2164809) 1 NC_002935.2 Similar to Rhizobium meliloti alcohol dehydrogenase AdhA or RA0704 or SMA1296 SWALL:ADHA_RHIME (SWALL:O31186) (340 aa) fasta scores: E(): 1.4e-71, 55.09% id in 334 aa, and to Pseudomonas aeruginosa alcohol dehydrogenase AdhA or PA5427 SWALL:Q9HTD9 (EMBL:AE004955) (342 aa) fasta scores: E(): 1.5e-79, 58.99% id in 339 aa; alcohol dehydrogenase 2164809 adhA 2649581 adhA Corynebacterium diphtheriae NCTC 13129 alcohol dehydrogenase NP_940430.1 2163769 R 257309 CDS NP_940431.1 38234664 2649582 complement(2164963..2166483) 1 NC_002935.2 Similar to many eg. Acinetobacter spM-1. aldehyde dehydrogenase 1 Ald1 TR:Q9FDS1 (EMBL:AB042203) (503 aa) fasta scores: E(): 2.5e-143, 69.18% id in 503 aa, and to Alcaligenes eutrophus acetaldehyde dehydrogenase II AcoD SW:DHA2_ALCEU (P46368) (506 aa) fasta scores: E(): 1.8e-135, 66.39% id in 497 aa; aldehyde dehydrogenase 2166483 2649582 DIP2115 Corynebacterium diphtheriae NCTC 13129 aldehyde dehydrogenase NP_940431.1 2164963 R 257309 CDS NP_940432.1 38234665 2649583 2166772..2168376 1 NC_002935.2 No significant database matches. Lies in a DNA region of unusually low G+C content.; membrane anchored protein 2168376 2649583 DIP2116 Corynebacterium diphtheriae NCTC 13129 membrane anchored protein NP_940432.1 2166772 D 257309 CDS NP_940433.1 38234666 2649584 complement(2168433..2168831) 1 NC_002935.2 Similar to Streptomyces coelicolor heat shock protein HspR or SCH44.08c SW:HSPR_STRCO (P40183) (151 aa) fasta scores: E(): 5.4e-16, 52.59% id in 135 aa, and to Mycobacterium tuberculosis HspR or Rv0353 or MTCY13E10.13 TR:O06302 (EMBL:Z95324) (126 aa) fasta scores: E(): 6.6e-23, 66.66% id in 117 aa; chaperone locus transcriptional regulator, HspR 2168831 hspR 2649584 hspR Corynebacterium diphtheriae NCTC 13129 chaperone locus transcriptional regulator, HspR NP_940433.1 2168433 R 257309 CDS NP_940434.1 38234667 2649585 complement(2168853..2170025) 1 NC_002935.2 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 2170025 dnaJ1 2649585 dnaJ1 Corynebacterium diphtheriae NCTC 13129 molecular chaperone DnaJ NP_940434.1 2168853 R 257309 CDS NP_940435.1 38234668 2649586 complement(2170135..2170794) 1 NC_002935.2 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 2170794 grpE 2649586 grpE Corynebacterium diphtheriae NCTC 13129 heat shock protein GrpE NP_940435.1 2170135 R 257309 CDS NP_940436.1 38234669 2649587 complement(2170794..2172629) 1 NC_002935.2 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 2172629 dnaK 2649587 dnaK Corynebacterium diphtheriae NCTC 13129 molecular chaperone DnaK NP_940436.1 2170794 R 257309 CDS NP_940437.1 38234670 2649588 2173043..2174347 1 NC_002935.2 Some similarity to integral membrane sensory proteins though DIP2121 does not appear to be a membrane protein. Similar to Rhodobacter capsulatus potential sensory protein TR:O68073 (EMBL:AF010496) (416 aa) fasta scores: E(): 1.6e-11, 27.93% id in 426 aa, and to Escherichia coli ORFI protein TR:Q56321 (EMBL:X61367) (525 aa) fasta scores: E(): 2.2e-09, 25.78% id in 446 aa, and to Escherichia coli aerotaxis receptor Aer or Air or B3072 SW:AER_ECOLI (P50466) (506 aa) fasta scores: E(): 1e-08, 25.29% id in 423 aa; hypothetical protein 2174347 2649588 DIP2121 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940437.1 2173043 D 257309 CDS NP_940438.1 38234671 2649589 2174439..2175719 1 NC_002935.2 Similar to Streptomyces coelicolor integral membrane protein SCF6.09 TR:Q9RJL9 (EMBL:AL121849) (363 aa) fasta scores: E(): 3.1e-49, 44.27% id in 332 aa, and to Escherichia coli permease B2493 or Z3755 or ECS3355 SW:PERM_ECOLI (P77406) (353 aa) fasta scores: E(): 1.7e-18, 27.89% id in 337 aa; hypothetical protein 2175719 2649589 DIP2122 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940438.1 2174439 D 257309 CDS NP_940439.1 38234672 2649590 complement(2175813..2176625) 1 NC_002935.2 Similar to Escherichia coli transposase InsK for insertion sequence element IS150 or B3558 SW:INSK_ECOLI (P19769) (283 aa) fasta scores: E(): 1.4e-43, 44.86% id in 263 aa. Identical to DIP0434, DIP1517, DIP1526 and DIP1809; transposase 2176625 2649590 DIP2123 Corynebacterium diphtheriae NCTC 13129 transposase NP_940439.1 2175813 R 257309 CDS NP_940440.1 38234673 2649591 complement(2176673..2177155) 1 NC_002935.2 Similar to Streptococcus pneumoniae hypothetical 20.7 kDa protein TR:Q9KK22 (EMBL:AF154034) (171 aa) fasta scores: E(): 1.3e-08, 33.75% id in 157 aa, and to Yersinia pestis insertion element IS1661 DNA-binding protein YPO3931 TR:CAC93394 (EMBL:AJ414159) (171 aa) fasta scores: E(): 0.00044, 25.45% id in 165 aa. Identical to DIP0435, DIP1518, DIP1525 and DIP1808; insertion element DNA-binding protein 2177155 2649591 DIP2124 Corynebacterium diphtheriae NCTC 13129 insertion element DNA-binding protein NP_940440.1 2176673 R 257309 CDS NP_940441.1 38234674 2649592 complement(2177232..2177873) 1 NC_002935.2 Similar to Streptomyces coelicolor ABC transporter ATP-binding protein SC9B5.22 TR:Q9ZBF8 (EMBL:AL035206) (222 aa) fasta scores: E(): 7.5e-19, 41.66% id in 216 aa, and to Escherichia coli nickel transport ATP-binding protein NikE or B3480 SW:NIKE_ECOLI (P33594) (268 aa) fasta scores: E(): 6.3e-17, 38.72% id in 204 aa; ABC transporter ATP-binding protein 2177873 2649592 DIP2125 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_940441.1 2177232 R 257309 CDS NP_940442.1 38234675 2649593 complement(2177860..2179488) 1 NC_002935.2 Similar to Streptomyces coelicolor transport permease SC9B5.20 TR:Q9ZBG0 (EMBL:AL035206) (312 aa) fasta scores: E(): 4.4e-32, 45.27% id in 254 aa, and to Bacillus subtilis dipeptide transport system permease DppC or DciAC SW:DPPC_BACSU (P26904) (320 aa) fasta scores: E(): 4.3e-23, 37.19% id in 242 aa; binding-protein-dependent integral membrane transport protein 2179488 2649593 DIP2126 Corynebacterium diphtheriae NCTC 13129 binding-protein-dependent integral membrane transport protein NP_940442.1 2177860 R 257309 CDS NP_940443.1 38234676 2649594 complement(2179481..2180479) 1 NC_002935.2 Similar to Streptomyces coelicolor transport permease SC9B5.19 TR:Q9ZBG1 (EMBL:AL035206) (334 aa) fasta scores: E(): 8.6e-44, 43.51% id in 324 aa, and to Bacillus subtilis oligopeptide transport system permease AppB SW:APPB_BACSU (P42062) (317 aa) fasta scores: E(): 6.2e-25, 28.61% id in 318 aa; binding-protein-dependent integral membrane transport protein 2180479 2649594 DIP2127 Corynebacterium diphtheriae NCTC 13129 binding-protein-dependent integral membrane transport protein NP_940443.1 2179481 R 257309 CDS NP_940444.1 38234677 2649595 complement(2180480..2182084) 1 NC_002935.2 Similar to Streptomyces coelicolor substrate binding protein SC9B5.18 TR:Q9ZBG2 (EMBL:AL035206) (542 aa) fasta scores: E(): 2e-50, 33.14% id in 516 aa, and to Streptomyces lividans Xp55 protein SW:XP55_STRLI (P06109) (542 aa) fasta scores: E(): 1.7e-43, 32.16% id in 485 aa; substrate-binding transport protein 2182084 2649595 DIP2128 Corynebacterium diphtheriae NCTC 13129 substrate-binding transport protein NP_940444.1 2180480 R 257309 CDS NP_940445.1 38234678 2649596 complement(2182285..2183871) 1 NC_002935.2 Similar to Mycobacterium tuberculosis phosphate permease Rv2281 or MT2339 or MTCY339.29C SW:YM81_MYCTU (Q50684) (552 aa) fasta scores: E(): 1.2e-121, 61% id in 518 aa; binding-protein-dependent integral membrane transport protein 2183871 2649596 DIP2129 Corynebacterium diphtheriae NCTC 13129 binding-protein-dependent integral membrane transport protein NP_940445.1 2182285 R 257309 CDS NP_940446.1 38234679 2649600 2190630..2194346 1 NC_002935.2 Full length similarity to Streptococcus pneumoniae phosphoribosylformylglycinamidine synthase, SP0045 TR:AAK74234 (EMBL:AE007322) (1241 aa) fasta scores: E(): 7.8e-167, 47.73% id in 1259 aa. Second two thirds similar to many others e.g. Mycobacterium tuberculosis phosphoribosylformylglycinamidine synthase II PurL or Rv0803 or MT0823 or MTCY07H7A.06c SW:PURL_MYCTU (P54876) (754 aa) fasta scores: E(): 8.3e-22, 26.35% id in 740 aa; phosphoribosylformylglycinamidine synthase 2194346 2649600 DIP2130 Corynebacterium diphtheriae NCTC 13129 phosphoribosylformylglycinamidine synthase NP_940446.1 2190630 D 257309 CDS NP_940447.1 38234680 2649601 complement(2194426..2195016) 1 NC_002935.2 Catalyzes hydrolysis of n-ribosyl-purine into a purine and d-ribose; nucleosidase 2195016 2649601 DIP2131 Corynebacterium diphtheriae NCTC 13129 nucleosidase NP_940447.1 2194426 R 257309 CDS NP_940448.1 38234681 2649602 2195144..2195632 1 NC_002935.2 Weakly similar to Rattus norvegicus NADPH:adrenodoxin oxidoreductase, mitochondrial precursor FdxR SW:ADRO_RAT (P56522) (494 aa) fasta scores: E(): 0.002, 28.3% id in 159 aa, and to Streptomyces coelicolor ferredoxin/ferredoxin-NADP reductase SCF15.02 TR:Q9RK35 (EMBL:AL132856) (454 aa) fasta scores: E(): 0.048, 29% id in 131 aa; oxidoreductase 2195632 2649602 DIP2132 Corynebacterium diphtheriae NCTC 13129 oxidoreductase NP_940448.1 2195144 D 257309 CDS NP_940449.1 38234682 2649603 2195706..2198210 1 NC_002935.2 Similar to many eg. Mycobacterium tuberculosis hypothetical 95.5 kDa protein Rv0338c or MT0352 or MTCY279.05C TR:O33268 (EMBL:Z97991) (882 aa) fasta scores: E(): 2.4e-55, 43.1% id in 877 aa. N-terminal region appears to be has possible membrane-spanning hydrophobic regions while the C-terminal region is rich in proline and alanine.; hypothetical protein 2198210 2649603 DIP2133 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940449.1 2195706 D 257309 CDS NP_940450.1 38234683 2649604 2198286..2198906 1 NC_002935.2 N-terminus similar to those from other actinomycetes eg. Saccharopolyspora erythraea Orf122 protein TR:Q54106 (EMBL:X92556) (121 aa) fasta scores: E(): 0.0076, 31.15% id in 138 aa, and to Streptomyces coelicolor hypothetical 30.8 kDa protein SCE6.30c TR:Q9KZR0 (EMBL:AL353832) (277 aa) fasta scores: E(): 0.02, 36.76% id in 68 aa; hypothetical protein 2198906 2649604 DIP2134 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940450.1 2198286 D 257309 CDS NP_940451.1 38234684 2649605 complement(2198998..2200089) 1 NC_002935.2 Similar to Neisseria meningitidis zinc-binding alcohol dehydrogenase NMA0808 TR:Q9JVJ8 (EMBL:AL162754) (354 aa) fasta scores: E(): 1.1e-85, 64.62% id in 359 aa, and to Bacillus cereus acetylacetoin reductase AacR TR:BAB60856 (EMBL:AB063194) (349 aa) fasta scores: E(): 5.6e-47, 42.25% id in 355 aa, and to Pseudomonas putida 2,3-butanediol dehydrogenase Adh TR:Q59696 (EMBL:L35343) (362 aa) fasta scores: E(): 6.6e-40, 37.63% id in 364 aa; zinc-binding alcohol dehydrogenase 2200089 2649605 DIP2135 Corynebacterium diphtheriae NCTC 13129 zinc-binding alcohol dehydrogenase NP_940451.1 2198998 R 257309 CDS NP_940452.1 38234685 2649606 2200331..2201602 1 NC_002935.2 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 2201602 2649606 DIP2136 Corynebacterium diphtheriae NCTC 13129 aminotransferase NP_940452.1 2200331 D 257309 CDS NP_940453.1 38234686 2649607 2201757..2202914 1 NC_002935.2 Similar to Streptomyces coelicolor membrane protein SCQ11.10c TR:Q9X9U1 (EMBL:AL096823) (513 aa) fasta scores: E(): 2.1e-35, 37.59% id in 383 aa, and to Pseudomonas aeruginosa sensor protein GlpS or pa1977 SW:GLPS_PSEAE (P29370) (287 aa) fasta scores: E(): 2.5, 29.41% id in 238 aa; hypothetical protein 2202914 2649607 DIP2137 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940453.1 2201757 D 257309 CDS NP_940454.1 38234687 2649608 2202940..2206089 1 NC_002935.2 catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 2206089 lysS 2649608 lysS Corynebacterium diphtheriae NCTC 13129 lysyl-tRNA synthetase NP_940454.1 2202940 D 257309 CDS NP_940455.1 38234688 2649609 complement(2206196..2206873) 1 NC_002935.2 hypothetical protein 2206873 2649609 DIP2139 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940455.1 2206196 R 257309 CDS NP_940456.1 38234689 2649610 complement(2206836..2207456) 1 NC_002935.2 Weakly similar to Lactococcus lactis unknown protein YldA or ll1118 TR:Q9CGH8 (EMBL:AE006344) (209 aa) fasta scores: E(): 0.092, 24% id in 175 aa; integral membrane protein 2207456 2649610 DIP2140 Corynebacterium diphtheriae NCTC 13129 integral membrane protein NP_940456.1 2206836 R 257309 CDS NP_940457.1 38234690 2649611 complement(2207481..2208686) 1 NC_002935.2 Similar to Streptomyces coelicolor UDP-glucose 6-dehydrogenase SCBAC19G2.07 TR:CAC44517 (EMBL:AL596138) (447 aa) fasta scores: E(): 2.8e-33, 40.75% id in 422 aa, and to Pseudomonas aeruginosa UDP-glucose 6-dehydrogenase Udg or pa2022 SW:UDG_PSEAE (O86422) (453 aa) fasta scores: E(): 1.9e-26, 39.66% id in 358 aa, and to Rhizobium meliloti UDP-glucose 6-dehydrogenase Rkpk or r01082 or smc02641 SW:UDG_RHIME (O54068) (437 aa) fasta scores: E(): 8.9e-26, 37.71% id in 411 aa, and to Escherichia coli UDP-glucose 6-dehydrogenase KfiD SW:UDG5_ECOLI (Q47329) (392 aa) fasta scores: E(): 1.5e-24, 32.81% id in 323 aa; UDP-glucose 6-dehydrogenase 2208686 2649611 DIP2141 Corynebacterium diphtheriae NCTC 13129 UDP-glucose 6-dehydrogenase NP_940457.1 2207481 R 257309 CDS NP_940458.1 38234691 2649612 complement(2208692..2209255) 1 NC_002935.2 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 2209255 dcd 2649612 dcd Corynebacterium diphtheriae NCTC 13129 deoxycytidine triphosphate deaminase NP_940458.1 2208692 R 257309 CDS NP_940459.1 38234692 2649614 complement(2209550..2210329) 1 NC_002935.2 Weakly similar to Bacillus subtilis hypothetical YxlG TR:P94375 (EMBL:D83026) (259 aa) fasta scores: E(): 1.2, 24.72% id in 182 aa, and to Rhizobium loti Mll2378 protein TR:Q98IJ2 (EMBL:AP002999) (339 aa) fasta scores: E(): 1.3, 26.98% id in 252 aa. Lies alongside a ABC transporter ATP-binding subunit.; ABC transporter inner membrane protein 2210329 2649614 DIP2143 Corynebacterium diphtheriae NCTC 13129 ABC transporter inner membrane protein NP_940459.1 2209550 R 257309 CDS NP_940460.1 38234693 2649615 complement(2210326..2211159) 1 NC_002935.2 Similar to many eg. Bacillus licheniformis bacitracin transport ATP-binding protein BcrA SW:BCRA_BACLI (P42332) (306 aa) fasta scores: E(): 2.7e-22, 35.01% id in 277 aa; ABC transporter ATP-binding protein 2211159 2649615 DIP2144 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_940460.1 2210326 R 257309 CDS NP_940461.1 38234694 2649616 complement(2211156..2211488) 1 NC_002935.2 hypothetical protein 2211488 2649616 DIP2145 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940461.1 2211156 R 257309 CDS NP_940462.1 38234695 2649617 complement(2211488..2212180) 1 NC_002935.2 hypothetical protein 2212180 2649617 DIP2146 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940462.1 2211488 R 257309 CDS NP_940463.1 38234696 2649618 complement(2212180..2212506) 1 NC_002935.2 Similar to Streptomyces coelicolor conserved hypothetical protein SCE20.33c TR:Q9RD92 (EMBL:AL136058) (125 aa) fasta scores: E(): 3e-12, 44.79% id in 96 aa, and to Caulobacter crescentus hypothetical protein Cc3408 TR:Q9A2Z8 (EMBL:AE006001) (108 aa) fasta scores: E(): 2.9e-10, 42.26% id in 97 aa; hypothetical protein 2212506 2649618 DIP2147 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940463.1 2212180 R 257309 CDS NP_940464.1 38234697 2649621 complement(2213799..2214419) 1 NC_002935.2 hypothetical protein 2214419 2649621 DIP2152 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940464.1 2213799 R 257309 CDS NP_940465.1 38234698 2649622 complement(2214506..2214883) 1 NC_002935.2 Similar to Bacteriophage phi-105 holin TR:Q38456 (EMBL:L35561) (124 aa) fasta scores: E(): 5.4e-14, 41.22% id in 114 aa, and to Escherichia coli O157:H7 holin protein of prophage cp-933c Z1852 or ECS1595 TR:AAG55949 (EMBL:AE005328) (129 aa) fasta scores: E(): 1.7e-07, 40.77% id in 103 aa; bacteriophage holin protein 2214883 2649622 DIP2153 Corynebacterium diphtheriae NCTC 13129 bacteriophage holin protein NP_940465.1 2214506 R 257309 CDS NP_940466.1 38234699 2649623 complement(2214765..2215559) 1 NC_002935.2 Similar to Xylella fastidiosa phage-related protein XF0684 TR:Q9PFH4 (EMBL:AE003912) (503 aa) fasta scores: E(): 1.8e-13, 56.52% id in 92 aa, and to Lactobacillus casei bacteriophage A2 Antirepressor Ant TR:O64368 (EMBL:AJ251789) (160 aa) fasta scores: E(): 2.9e-08, 36.69% id in 139 aa, and to Bacteriophage r1t integrase, repressor protein TR:Q38091 (EMBL:U38906) (265 aa) fasta scores: E(): 2.3e-06, 36.98% id in 219 aa; DNA-binding bacteriophage protein 2215559 2649623 DIP2154 Corynebacterium diphtheriae NCTC 13129 DNA-binding bacteriophage protein NP_940466.1 2214765 R 257309 CDS NP_940467.1 38234700 2649624 2215819..2216805 1 NC_002935.2 Similar to Pasteurella multocida hypothetical protein Pm1783 TR:Q9CK51 (EMBL:AE006215) (316 aa) fasta scores: E(): 1.4e-26, 32.226% id in 301 aa, and to Staphylococcus aureus subspaureus Mu50. hypothetical 38.5 kDa protein Sav0801 TR:BAB56963 (EMBL:AP003360) (322 aa) fasta scores: E(): 2.7e-07, 22.876% id in 306 aa; hypothetical protein 2216805 2649624 DIP2155 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940467.1 2215819 D 257309 CDS NP_940468.1 38234701 2649626 complement(2217901..2219655) 1 NC_002935.2 Similar to Yersinia pestis YbtP TR:Q9ZG01 (EMBL:AF091251) (600 aa) fasta scores: E(): 5e-46, 31.046% id in 583 aa, and to Escherichia coli, and probable transport ATP-binding protein MsbA or B0914 or Z1260 or ECS0997 SW:MSBA_ECOLI (P27299) (582 aa) fasta scores: E(): 1.6e-42, 30.969% id in 578 aa; ABC transporter 2219655 2649626 DIP2158 Corynebacterium diphtheriae NCTC 13129 ABC transporter NP_940468.1 2217901 R 257309 CDS NP_940469.1 38234702 2649627 complement(2219658..2221439) 1 NC_002935.2 Similar to Yersinia enterocolitica lipoprotein inner membrane ABC-transporter, Irp6 TR:Q9X9I5 (EMBL:AJ132668) (600 aa) fasta scores: E(): 2.5e-43, 34.286% id in 560 aa, and to Streptomyces natalensis PimB protein TR:Q9EW97 (EMBL:AJ278573) (626 aa) fasta scores: E(): 3e-37, 32.519% id in 532 aa; ABC transporter 2221439 2649627 DIP2159 Corynebacterium diphtheriae NCTC 13129 ABC transporter NP_940469.1 2219658 R 257309 CDS NP_940470.1 38234703 2649628 complement(2221492..2229396) 1 NC_002935.2 Similar to Streptomyces verticillus polyketide synthase BlmVIII (bleomycin biosynthesis) TR:Q9FB25 (EMBL:AF210249) (1841 aa) fasta scores: E(): 1.3e-72, 27.240% id in 1931 aa, and to Streptomyces noursei nystatin biosynthesis polyketide synthase Nys TR:Q9L4W3 (EMBL:AF263912) (11096 aa) fasta scores: E(): 4e-71, 33.107% id in 882 aa, and to Amycolatopsis mediterranei rifamycin polyketide synthase TR:Q9F847 (EMBL:AF262754) (1265 aa) fasta scores: E(): 7.7e-61, 31.042% id in 902 aa; modular polyketide synthase 2229396 2649628 DIP2160 Corynebacterium diphtheriae NCTC 13129 modular polyketide synthase NP_940470.1 2221492 R 257309 CDS NP_940471.1 38234704 2649629 complement(2229393..2234573) 1 NC_002935.2 Similar to Stigmatella aurantiaca myxothiazol synthase MtaC TR:Q9RFK9 (EMBL:AF188287) (1290 aa) fasta scores: E(): 1.7e-86, 35.694% id in 1073 aa, and to Polyangium cellulosum epothilone biosynthase EpoB TR:Q9KIZ9 (EMBL:AF217189) (1410 aa) fasta scores: E(): 1.8e-81, 35.385% id in 975 aa, and to Pseudomonas aeruginosa pyochelin synthetase PchF or PA4225 TR:Q9HWG4 (EMBL:AE004839) (1809 aa) fasta scores: E(): 1.9e-81, 37.017% id in 932 aa; non-ribosomal peptide synthetase 2234573 2649629 DIP2161 Corynebacterium diphtheriae NCTC 13129 non-ribosomal peptide synthetase NP_940471.1 2229393 R 257309 CDS NP_940472.1 38234705 2649630 2234961..2236460 1 NC_002935.2 Similar to Streptomyces coelicolor secreted solute-binding protein SC4C2.12 TR:Q9EWQ0 (EMBL:AL450432) (528 aa) fasta scores: E(): 4.7e-23, 29.923% id in 518 aa, and to Rhizobium loti ABC transporter, binding protein MLL5127 TR:Q98CJ3 (EMBL:AP003005) (528 aa) fasta scores: E(): 1.4e-22, 27.921% id in 505 aa. Note: Contains a twin-arginine translocation (TAT) system recognition motif (RRDFLK) at the N-terminal region; ABC transporter substrate-binding protein 2236460 2649630 DIP2162 Corynebacterium diphtheriae NCTC 13129 ABC transporter substrate-binding protein NP_940472.1 2234961 D 257309 CDS NP_940473.1 38234706 2649631 2236473..2237426 1 NC_002935.2 Similar to Streptomyces coelicolor metal transport integral membrane protein SC4C2.13 TR:Q9EWP9 (EMBL:AL450432) (316 aa) fasta scores: E(): 3.2e-30, 39.344% id in 305 aa, and to Rhizobium meliloti ABC transporter permease SMA0300 TR:AAK64819 (EMBL:AE007209) (317 aa) fasta scores: E(): 2.1e-20, 27.303% id in 304 aa; ABC transporter permease 2237426 2649631 DIP2163 Corynebacterium diphtheriae NCTC 13129 ABC transporter permease NP_940473.1 2236473 D 257309 CDS NP_940474.1 38234707 2648910 2237423..2238244 1 NC_002935.2 Similar to Streptomyces coelicolor transport system integral membrane protein SC4C2.14 TR:Q9EWP8 (EMBL:AL450432) (284 aa) fasta scores: E(): 4.4e-17, 32.567% id in 261 aa, and to Rhizobium loti ABC transporter, permease MLL7032 TR:Q987J0 (EMBL:AP003010) (283 aa) fasta scores: E(): 1.9e-14, 30.859% id in 256 aa; ABC transporter permease 2238244 2648910 DIP2164 Corynebacterium diphtheriae NCTC 13129 ABC transporter permease NP_940474.1 2237423 D 257309 CDS NP_940475.1 38234708 2648911 2238241..2239647 1 NC_002935.2 Similar to Rhizobium meliloti ABC transporter SMA0298 TR:AAK64817 (EMBL:AE007209) (604 aa) fasta scores: E(): 1.5e-15, 27.536% id in 552 aa, and to Streptomyces coelicolor peptide transport ATP-binding protein SC9F2.04 TR:Q9Z531 (EMBL:AL035559) (359 aa) fasta scores: E(): 3.4e-15, 39.409% id in 203 aa; ABC transporter ATP-binding protein 2239647 2648911 DIP2165 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_940475.1 2238241 D 257309 CDS NP_940476.1 38234709 2648912 2239756..2241060 1 NC_002935.2 Similar to Amycolatopsis orientalis integral membrane sugar transporter CZA382.17c TR:Q9XBD4 (EMBL:AL078635) (444 aa) fasta scores: E(): 3.8e-43, 37.264% id in 424 aa, and to Burkholderia cepacia MopB protein TR:Q45082 (EMBL:U29532) (449 aa) fasta scores: E(): 1.2e-40, 35.885% id in 418 aa; ABC transporter permease 2241060 2648912 DIP2166 Corynebacterium diphtheriae NCTC 13129 ABC transporter permease NP_940476.1 2239756 D 257309 CDS NP_940477.1 38234710 2648913 2241109..2241360 1 NC_002935.2 Similar to fragment of Mycobacterium tuberculosis 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE or Rv1133c or MT1165 or MTC22G8.22 SW:METE_MYCTU (O06584) (759 aa) fasta scores: E(): 2.5e-06, 70.732% id in 41 aa, and to Streptomyces griseus subspgriseus. 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase- like protein TR:Q9KHC5 (EMBL:AF263012) (774 aa) fasta scores: E(): 4.1e-06, 77.778% id in 36 aa, and to Saccharomyces cerevisiae 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Met6 or YER091c SW:METE_YEAST (P05694) (766 aa) fasta scores: E(): 7.8e-05, 71.429% id in 35 aa; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 2241360 metE 2648913 metE Corynebacterium diphtheriae NCTC 13129 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase NP_940477.1 2241109 D 257309 CDS NP_940478.1 38234711 2648914 2241389..2242600 1 NC_002935.2 Similar to Streptomyces coelicolor membrane transport protein SCC75A.30c TR:Q9RKP4 (EMBL:AL133220) (428 aa) fasta scores: E(): 5.2e-40, 36.935% id in 398 aa, and to Escherichia coli bicyclomycin resistance protein Bcr or BicA or BicR or Sur or SuxA or b2182 SW:BCR_ECOLI (P28246) (396 aa) fasta scores: E(): 3.4e-31, 30.548% id in 383 aa; integral membrane transport protein 2242600 2648914 DIP2168 Corynebacterium diphtheriae NCTC 13129 integral membrane transport protein NP_940478.1 2241389 D 257309 CDS NP_940479.1 38234712 2648915 complement(2242597..2244075) 1 NC_002935.2 hypothetical protein 2244075 2648915 DIP2169 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940479.1 2242597 R 257309 CDS NP_940480.1 38234713 2648916 complement(2244077..2244868) 1 NC_002935.2 Similar to Bacillus subtilis hypothetical 27.6 kDa protein in fnr-narG intergenic region YwiC SW:YWIC_BACSU (P46909) (239 aa) fasta scores: E(): 5e-08, 28.571% id in 259 aa, and to Haemophilus influenzae hypothetical protein HI1626 SW:YG26_HAEIN (P44278) (238 aa) fasta scores: E(): 3.6e-06, 25.758% id in 264 aa; hypothetical protein 2244868 2648916 DIP2170 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940480.1 2244077 R 257309 CDS NP_940481.1 38234714 2648917 complement(2244892..2246574) 1 NC_002935.2 hypothetical protein 2246574 2648917 DIP2171 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940481.1 2244892 R 257309 CDS NP_940482.1 38234715 2648918 complement(2246580..2247743) 1 NC_002935.2 Similar to Mycobacterium leprae secreted glycosyl hydrolase ML2569 or MLCB1883.14 TR:O69499 (EMBL:AL022486) (387 aa) fasta scores: E(): 3e-40, 42.33% id in 385 aa, and to Vibrio furnissii beta-hexosaminidase NagZ or Exo II SW:NAGZ_VIBFU (P96157) (329 aa) fasta scores: E(): 9e-13, 30.94% id in 265 aa. Note: Contains a twin-arginine translocation (TAT) system recognition motif (RRVFTP) at the N-terminal region; secreted glycosyl hydrolase 2247743 2648918 DIP2172 Corynebacterium diphtheriae NCTC 13129 secreted glycosyl hydrolase NP_940482.1 2246580 R 257309 CDS NP_940483.1 38234716 2648919 2247778..2247966 1 NC_002935.2 Similar to Mycobacterium tuberculosis secreted protein Rv0236.1 precursor or Rv0236A or MT0250 SW:Y23A_MYCTU (P58240) (57 aa) fasta scores: E(): 0.39, 32.72% id in 55 aa; hypothetical protein 2247966 2648919 DIP2173 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940483.1 2247778 D 257309 CDS NP_940484.1 38234717 2648920 2247967..2251044 1 NC_002935.2 Similar to Mycobacterium leprae possible integral membrane protein ML2570 TR:Q9CD19 (EMBL:AL583926) (1405 aa) fasta scores: E(): 2.5e-17, 37.3% id in 823 aa, and to Mycobacterium tuberculosis hypothetical 146.3 kDa protein Rv0236c or MT0247 or MTV034.01c or MTV034.02c or MTCY08D5.32c TR:AAK44467 (EMBL:Z92669) (1400 aa) fasta scores: E(): 7.4e-17, 38.32% id in 822 aa. ORF overlaps with convergent downstream ORF; hypothetical protein 2251044 2648920 DIP2174 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940484.1 2247967 D 257309 CDS NP_940485.1 38234718 2648921 complement(2250936..2252075) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 43.3 kDa protein Rv0228 or MT0238 or MTCY08D5.23 TR:P96410 (EMBL:Z92669) (407 aa) fasta scores: E(): 1.2e-31, 38.84% id in 381 aa, and to Streptomyces thermotolerans macrolide antibiotics 3-O-acyltransferase AcyA TR:Q56074 (EMBL:D30759) (389 aa) fasta scores: E(): 6e-07, 30.43% id in 322 aa, and to Streptomyces mycarofaciens acyltransferase MdmB SW:MDMB_STRMY (Q00718) (387 aa) fasta scores: E(): 8e-07, 29.14% id in 398 aa. ORF overlaps with convergent downstream ORF.; integral membrane acyltransferase 2252075 2648921 DIP2175 Corynebacterium diphtheriae NCTC 13129 integral membrane acyltransferase NP_940485.1 2250936 R 257309 CDS NP_940486.1 38234719 2648922 2252088..2253182 1 NC_002935.2 Similar to Mycobacterium leprae integral membrane protein Ml2581 TR:Q9CD18 (EMBL:AL583926) (427 aa) fasta scores: E(): 8.6e-14, 27.79% id in 367 aa; integral membrane protein 2253182 2648922 DIP2176 Corynebacterium diphtheriae NCTC 13129 integral membrane protein NP_940486.1 2252088 D 257309 CDS NP_940487.1 38234720 2648923 2253173..2254585 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 59.1 kDa protein Rv0226c or MTCY08D5.21c TR:P96408 (EMBL:Z92669) (576 aa) fasta scores: E(): 6e-08, 30% id in 530 aa. ORF overlaps with convergent downstream ORF; hypothetical protein 2254585 2648923 DIP2177 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940487.1 2253173 D 257309 CDS NP_940488.1 38234721 2648924 complement(2254468..2255622) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 42.1 kDa protein Rv0225 or MTCY08D5.20 TR:P96407 (EMBL:Z92669) (384 aa) fasta scores: E(): 3.5e-62, 51.48% id in 371 aa. ORF overlaps with convergent downstream ORF; hypothetical protein 2255622 2648924 DIP2178 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940488.1 2254468 R 257309 CDS NP_940489.1 38234722 2648925 2255664..2256398 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 27.5 kDa protein Rv0224c or MTCY08D5.19c TR:P96406 (EMBL:Z92669) (254 aa) fasta scores: E(): 2.9e-56, 63.41% id in 246 aa, and to Streptomyces coelicolor methyltransferase SCC53.08c TR:Q9KXK3 (EMBL:AL357591) (244 aa) fasta scores: E(): 7.1e-06, 32.94% id in 173 aa; hypothetical protein 2256398 2648925 DIP2179 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940489.1 2255664 D 257309 CDS NP_940490.1 38234723 2648926 complement(2256423..2258261) 1 NC_002935.2 catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP; phosphoenolpyruvate carboxykinase 2258261 pckG 2648926 pckG Corynebacterium diphtheriae NCTC 13129 phosphoenolpyruvate carboxykinase NP_940490.1 2256423 R 257309 CDS NP_940491.1 38234724 2648927 2258718..2259497 1 NC_002935.2 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 2259497 trmB 2648927 trmB Corynebacterium diphtheriae NCTC 13129 tRNA (guanine-N(7)-)-methyltransferase NP_940491.1 2258718 D 257309 CDS NP_940492.1 38234725 2648928 2259494..2260114 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 26.2 kDa protein Rv0207c or MT0217 or MTCY08D5.02c TR:AAK44438 (EMBL:Z92669) (244 aa) fasta scores: E(): 8.6e-51, 64.03% id in 203 aa; hypothetical protein 2260114 2648928 DIP2182 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940492.1 2259494 D 257309 CDS NP_940493.1 38234726 2648929 2260129..2262369 1 NC_002935.2 Similar to Mycobacterium tuberculosis membrane protein MmpL3 or Rv0206c or MT0216 or MTV033.14c or MTCY08D5.01c SW:MML3_MYCTU (O53657) (944 aa) fasta scores: E(): 2.1e-45, 44.69% id in 754 aa, and to Streptomyces coelicolor integral membrane protein SCC24.25 TR:Q9L092 (EMBL:AL163003) (743 aa) fasta scores: E(): 4.6e-42, 34.79% id in 750 aa; integral membrane protein 2262369 2648929 DIP2183 Corynebacterium diphtheriae NCTC 13129 integral membrane protein NP_940493.1 2260129 D 257309 CDS NP_940494.1 38234727 2648930 2262371..2263414 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 44.0 kDa protein Rv0204c or MT0214 or MTV033.12c TR:O53655 (EMBL:AL021928) (412 aa) fasta scores: E(): 3.4e-15, 30.24% id in 324 aa; integral membrane protein 2263414 2648930 DIP2184 Corynebacterium diphtheriae NCTC 13129 integral membrane protein NP_940494.1 2262371 D 257309 CDS NP_940495.1 38234728 2648931 2263411..2263767 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 12.6 kDa protein Rv0401 or MTCY04D9.14 TR:P95210 (EMBL:Z84725) (123 aa) fasta scores: E(): 5.3e-11, 36.6% id in 112 aa; integral membrane protein 2263767 2648931 DIP2185 Corynebacterium diphtheriae NCTC 13129 integral membrane protein NP_940495.1 2263411 D 257309 CDS NP_940496.1 38234729 2648935 complement(2266345..2267895) 1 NC_002935.2 Similar to Streptomyces coelicolor propionyl-CoA carboxylase complex B subunit PccB TR:Q9X4K7 (EMBL:AF113605) (530 aa) fasta scores: E(): 8.2e-102, 52.29% id in 522 aa, and to Mycobacterium tuberculosis propionyl-CoA carboxylase AccD4 or Rv3799c or MTV026.04c TR:O53578 (EMBL:AL022076) (518 aa) fasta scores: E(): 2.2e-106, 54.51% id in 510 aa, and to Saccharopolyspora erythraea propionyl-CoA carboxylase beta chain PccB SW:PCCB_SACER (P53003) (546 aa) fasta scores: E(): 1.2e-88, 51.88% id in 530 aa; propionyl-CoA carboxylase subunit beta 2267895 pccB 2648935 pccB Corynebacterium diphtheriae NCTC 13129 propionyl-CoA carboxylase subunit beta NP_940496.1 2266345 R 257309 CDS NP_940497.1 38234730 2648936 complement(2267907..2272667) 1 NC_002935.2 Similar to Mycobacterium tuberculosis polyketide synthase PKS13 or Rv3800c or MTV026.05c TR:O53579 (EMBL:AL022076) (1733 aa) fasta scores: E(): 5.4e-109, 44.5% id in 1719 aa, and to Polyangium cellulosum soraphen polyketide synthase A SorA TR:Q9ADL6 (EMBL:U24241) (6315 aa) fasta scores: E(): 6.2e-101, 35.96% id in 1090 aa; polyketide synthase 2272667 2648936 DIP2189 Corynebacterium diphtheriae NCTC 13129 polyketide synthase NP_940497.1 2267907 R 257309 CDS NP_940498.1 38234731 2648937 complement(2272766..2274580) 1 NC_002935.2 Activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 2274580 2648937 DIP2190 Corynebacterium diphtheriae NCTC 13129 acyl-CoA synthetase NP_940498.1 2272766 R 257309 CDS NP_940499.1 38234732 2648938 complement(2274655..2275566) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 35.4 kDa protein Rv3802c or MTV026.07c TR:O53581 (EMBL:AL022076) (336 aa) fasta scores: E(): 3.2e-34, 41.32% id in 317 aa; hypothetical protein 2275566 2648938 DIP2191 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940499.1 2274655 R 257309 CDS NP_940500.1 38234733 2648939 complement(2275572..2276087) 1 NC_002935.2 N-terminal region presents very low similarity to the following: Corynebacterium equii virulence associated protein VapA TR:Q9EUL9 (EMBL:AF116907) (189 aa) fasta scores: E(): 0.7, 27.92% id in 111 aa, and to Staphylococcus aureus hypothetical protein SAV2001 TR:BAB58163 (EMBL:AP003364) (154 aa) fasta scores: E(): 0.99, 26.61% id in 124 aa, and to Corynebacterium equii virulence-associated 15-17-kDa antigen VapA TR:Q57470 (EMBL:D21236) (189 aa) fasta scores: E(): 4.1, 27.02% id in 111 aa; hypothetical protein 2276087 2648939 DIP2192 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940500.1 2275572 R 257309 CDS NP_940501.1 38234734 2648940 complement(2276087..2278003) 1 NC_002935.2 Similar to Corynebacterium glutamicum PS1 protein precursor Csp1 SW:CSP1_CORGL (Q01377) (657 aa) fasta scores: E(): 1.8e-147, 57.51% id in 659 aa, and similar to but longer than Mycobacterium intracellulare antigen 85-B precursor FbpB SW:A85B_MYCIT (Q49575) (330 aa) fasta scores: E(): 1.8e-29, 37.18% id in 320 aa; hypothetical protein 2278003 csp1 2648940 csp1 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940501.1 2276087 R 257309 CDS NP_940502.1 38234735 2650335 complement(2278364..2279380) 1 NC_002935.2 Similar to Mycobacterium avium antigen 85-C precursor FbpC SW:A85C_MYCAV (O52972) (352 aa) fasta scores: E(): 3.7e-29, 34.32% id in 335 aa, and similar to but shorter than Corynebacterium glutamicum PS1 protein precursor Csp1 SW:CSP1_CORGL (Q01377) (657 aa) fasta scores: E(): 1.5e-28, 35.69% id in 297 aa; hypothetical protein 2279380 2650335 DIP2194 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940502.1 2278364 R 257309 CDS NP_940503.1 38234736 2649995 complement(2279547..2281235) 1 NC_002935.2 Similar to Mycobacterium tuberculosis membrane protein Rv3805c or MT3912 or MTV026.10c TR:O53582 (EMBL:AL022076) (627 aa) fasta scores: E(): 4.1e-25, 36.36% id in 594 aa; hypothetical protein 2281235 2649995 DIP2195 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940503.1 2279547 R 257309 CDS NP_940504.1 38234737 2649996 complement(2281244..2282221) 1 NC_002935.2 catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate; phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase 2282221 2649996 DIP2196 Corynebacterium diphtheriae NCTC 13129 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase NP_940504.1 2281244 R 257309 CDS NP_940505.1 38234738 2649997 complement(2282218..2282712) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 17.2 kDa protein Rv3807c or MTV026.12 TR:O53584 (EMBL:AL022076) (165 aa) fasta scores: E(): 7.9e-29, 52.56% id in 156 aa, and to Streptomyces coelicolor integral membrane protein SC5G8.11 TR:Q9KZA3 (EMBL:AL353872) (169 aa) fasta scores: E(): 9.1e-17, 46.04% id in 139 aa; hypothetical protein 2282712 2649997 DIP2197 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940505.1 2282218 R 257309 CDS NP_940506.1 38234739 2649998 complement(2282712..2284697) 1 NC_002935.2 Similar proteins from other actinomycetes eg. Mycobacterium tuberculosis hypothetical 71.5 kDa protein Rv3808c or MT3915 or MTV026.13c TR:O53585 (EMBL:AL022076) (637 aa) fasta scores: E(): 6.3e-88, 54.79% id in 657 aa; hypothetical protein 2284697 2649998 DIP2198 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940506.1 2282712 R 257309 CDS NP_940507.1 38234740 2649999 complement(2284782..2285297) 1 NC_002935.2 Similar to Corynebacterium ammoniagenes Orf2 protein TR:Q9RHY7 (EMBL:AB003155) (163 aa) fasta scores: E(): 6.5e-14, 39.21% id in 153 aa, and to Escherichia coli hypothetical protein YbjG or B0841 SW:YBJG_ECOLI (P75806) (198 aa) fasta scores: E(): 1.9e-06, 32.69% id in 156 aa; hypothetical protein 2285297 2649999 DIP2199 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940507.1 2284782 R 257309 CDS NP_940508.1 38234741 2650000 complement(2285338..2286915) 1 NC_002935.2 Similar to Bacillus subtilis betaine aldehyde dehydrogenase GbsA SW:DHAB_BACSU (P71016) (490 aa) fasta scores: E(): 2e-73, 54.63% id in 496 aa, and to Streptomyces coelicolor betaine aldehyde dehydrogenase GbsA TR:Q9K3J2 (EMBL:AL389898) (509 aa) fasta scores: E(): 3.2e-88, 55.75% id in 504 aa; betaine aldehyde dehydrogenase 2286915 gbsA 2650000 gbsA Corynebacterium diphtheriae NCTC 13129 betaine aldehyde dehydrogenase NP_940508.1 2285338 R 257309 CDS NP_940509.1 38234742 2650001 complement(2286982..2289207) 1 NC_002935.2 Similar to Escherichia coli high-affinity choline transport protein BetT or B0314 or Z0401 or ECS0360 SW:BETT_ECOLI (P17447) (677 aa) fasta scores: E(): 1.9e-118, 53.14% id in 668 aa, and to Erwinia amylovora high-affinity choline transport protein BetT TR:Q9F806 (EMBL:AF264948) (676 aa) fasta scores: E(): 2.5e-116, 51.98% id in 681 aa; high-affinity choline transport protein 2289207 betT 2650001 betT Corynebacterium diphtheriae NCTC 13129 high-affinity choline transport protein NP_940509.1 2286982 R 257309 CDS NP_940510.1 38234743 2650002 2289560..2291272 1 NC_002935.2 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine; choline dehydrogenase 2291272 betA 2650002 betA Corynebacterium diphtheriae NCTC 13129 choline dehydrogenase NP_940510.1 2289560 D 257309 CDS NP_940511.1 38234744 2650003 complement(2291458..2292672) 1 NC_002935.2 Similar to Escherichia coli UDP-galactopyranose mutase Glf or B2036 SW:GLF_ECOLI (P37747) (367 aa) fasta scores: E(): 5.4e-48, 45.35% id in 377 aa, and to Mycobacterium tuberculosis UDP-galactopyranose mutase Glf or Rv3809c or MTV026.14 TR:O06934 (EMBL:U96128) (399 aa) fasta scores: E(): 1.3e-121, 76.09% id in 389 aa; UDP-galactopyranose mutase 2292672 glf 2650003 glf Corynebacterium diphtheriae NCTC 13129 UDP-galactopyranose mutase NP_940511.1 2291458 R 257309 CDS NP_940512.1 38234745 2650004 complement(2292835..2293263) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 23.9 kDa protein Rv0836c or MT0857 or MTV043.29c TR:O53848 (EMBL:AL022004) (217 aa) fasta scores: E(): 4.3e-13, 37.98% id in 129 aa; hypothetical protein 2293263 2650004 DIP2204 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940512.1 2292835 R 257309 CDS NP_940513.1 38234746 2650005 complement(2293316..2294341) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 36.9 kDa protein Rv0837c or MTV043.30c TR:O53849 (EMBL:AL022004) (342 aa) fasta scores: E(): 7.7e-14, 30.38% id in 260 aa; DNA-binding protein 2294341 2650005 DIP2205 Corynebacterium diphtheriae NCTC 13129 DNA-binding protein NP_940513.1 2293316 R 257309 CDS NP_940514.1 38234747 2650006 complement(2294403..2294678) 1 NC_002935.2 nucleotide-binding protein 2294678 2650006 DIP2206 Corynebacterium diphtheriae NCTC 13129 nucleotide-binding protein NP_940514.1 2294403 R 257309 CDS NP_940515.1 38234748 2650007 2295148..2296968 1 NC_002935.2 Similar to Mycobacterium tuberculosis Csp or Rv3811 or MT3918 or MTV026.16 TR:O86334 (EMBL:Z97188) (539 aa) fasta scores: E(): 6.2e-33, 41.84% id in 411 aa, and to Streptomyces coelicolor secreted protein SCE34.21c TR:Q9KZK5 (EMBL:AL353862) (416 aa) fasta scores: E(): 5.6e-20, 28.74% id in 421 aa. Contains a proline/alanine rich region at residues 398-44, no present in homologues; hypothetical protein 2296968 2650007 DIP2207 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940515.1 2295148 D 257309 CDS NP_940516.1 38234749 2650008 complement(2297077..2297805) 1 NC_002935.2 Similar to Escherichia coli hypothetical protein YgcI precursor or B2757 SW:YGCI_ECOLI (Q46898) (224 aa) fasta scores: E(): 0.02, 26.816% id in 179 aa; hypothetical protein 2297805 2650008 DIP2208 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940516.1 2297077 R 257309 CDS NP_940517.1 38234750 2650009 complement(2297798..2298856) 1 NC_002935.2 Similar to Escherichia coli O157:H7 hypothetical 38.4 kDa protein ECS3612 TR:BAB37035 (EMBL:AP002562) (351 aa) fasta scores: E(): 8.7e-11, 33.333% id in 306 aa; hypothetical protein 2298856 2650009 DIP2209 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940517.1 2297798 R 257309 CDS NP_940518.1 38234751 2650010 complement(2298912..2299496) 1 NC_002935.2 hypothetical protein 2299496 2650010 DIP2210 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940518.1 2298912 R 257309 CDS NP_940519.1 38234752 2650011 complement(2299489..2301045) 1 NC_002935.2 hypothetical protein 2301045 2650011 DIP2211 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940519.1 2299489 R 257309 CDS NP_940520.1 38234753 2650012 2301411..2302097 1 NC_002935.2 Similar to Escherichia coli hypothetical 22.3 kDa protein in iap-cysH intergenic region YgcH or B2756 SW:YGCH_ECOLI (Q46897) (199 aa) fasta scores: E(): 0.042, 24.873% id in 197 aa; hypothetical protein 2302097 2650012 DIP2212 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940520.1 2301411 D 257309 CDS NP_940521.1 38234754 2650013 2302097..2304727 1 NC_002935.2 Similar to Escherichia coli hypothetical 100.5 kDa protein in iap-cysH intergenic region YgcB or B2761 SW:YGCB_ECOLI (P38036) (888 aa) fasta scores: E(): 1.1e-28, 28.827% id in 784 aa; helicase 2304727 2650013 DIP2213 Corynebacterium diphtheriae NCTC 13129 helicase NP_940521.1 2302097 D 257309 CDS NP_940522.1 38234755 2650014 2304729..2305688 1 NC_002935.2 Similar to Escherichia coli hypothetical 33.2 kDa protein in iap-cysH intergenic region YgbT or B2755 SW:YGBT_ECOLI (Q46896) (305 aa) fasta scores: E(): 6.7e-17, 29.119% id in 261 aa; hypothetical protein 2305688 2650014 DIP2214 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940522.1 2304729 D 257309 CDS NP_940523.1 38234756 2650015 2305689..2306003 1 NC_002935.2 Similar to Escherichia coli hypothetical 10.5 kDa protein in iap-cysH intergenic region YgbF or B2754 SW:YGBF_ECOLI (P45956) (94 aa) fasta scores: E(): 0.0075, 26.667% id in 90 aa; hypothetical protein 2306003 2650015 DIP2215 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940523.1 2305689 D 257309 CDS NP_940524.1 38234757 2650016 2307893..2308408 1 NC_002935.2 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 2308408 ssb2 2650016 ssb2 Corynebacterium diphtheriae NCTC 13129 single-stranded DNA-binding protein NP_940524.1 2307893 D 257309 CDS NP_940525.1 38234758 2650017 2308427..2308660 1 NC_002935.2 DNA-binding protein 2308660 2650017 DIP2217 Corynebacterium diphtheriae NCTC 13129 DNA-binding protein NP_940525.1 2308427 D 257309 CDS NP_940526.1 38234759 2650018 2309127..2309804 1 NC_002935.2 Similar to Mycobacteriophage TM4 gp6 TR:Q9ZX71 (EMBL:AF068845) (509 aa) fasta scores: E(): 1.4e-05, 32.903% id in 155 aa; hypothetical protein 2309804 2650018 DIP2218 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940526.1 2309127 D 257309 CDS NP_940527.1 38234760 2650019 2309879..2310220 1 NC_002935.2 Some similarity to San Miguel sea lion virus RNA dependent RNA polymerase 3d TR:O09787 (EMBL:U52090) (149 aa) fasta scores: E(): 6.6, 31.776% id in 107 aa; hypothetical protein 2310220 2650019 DIP2219 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940527.1 2309879 D 257309 CDS NP_940528.1 38234761 2650020 2310210..2310485 1 NC_002935.2 hypothetical protein 2310485 2650020 DIP2220 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940528.1 2310210 D 257309 CDS NP_940529.1 38234762 2650021 complement(2310601..2310759) 1 NC_002935.2 hypothetical protein 2310759 2650021 DIP2222 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940529.1 2310601 R 257309 CDS NP_940530.1 38234763 2650022 complement(2310948..2311757) 1 NC_002935.2 No significant database matches. Note: Contains a potential sortase anchor site (LGNTG) upstream of the C-terminal region transmembrane domain; surface-anchored protein 2311757 2650022 DIP2223 Corynebacterium diphtheriae NCTC 13129 surface-anchored protein NP_940530.1 2310948 R 257309 CDS NP_940531.1 38234764 2650023 complement(2311830..2312876) 1 NC_002935.2 Similar to Actinomyces naeslundii fimbriae-associated protein TR:O68213 (EMBL:AF019629) (365 aa) fasta scores: E(): 2.3e-33, 42.500% id in 280 aa, and to Staphylococcus aureus sortase SrtA TR:Q9S446 (EMBL:AF162687) (206 aa) fasta scores: E(): 0.0034, 26.115% id in 157 aa; fimbrial associated sortase-like protein 2312876 2650023 DIP2224 Corynebacterium diphtheriae NCTC 13129 fimbrial associated sortase-like protein NP_940531.1 2311830 R 257309 CDS NP_940532.1 38234765 2650024 complement(2312860..2313816) 1 NC_002935.2 Similar to Actinomyces naeslundii fimbria-associated protein TR:O68213 (EMBL:AF019629) (365 aa) fasta scores: E(): 3.2e-52, 51.254% id in 279 aa, and to Bifidobacterium longum NCC2705 sortase-like protein BL0676 SWALL:AAN24497 (EMBL:AE014690) (328 aa) fasta scores: E(): 3.6e-28, 34.02% id in 291 aa, and to Staphylococcus aureus subsp aureus Mu50 sortase SrtA TR:BAB58690 (EMBL:AP003365) (206 aa) fasta scores: E(): 0.027, 29.371% id in 143 aa; fimbrial associated sortase-like protein 2313816 2650024 DIP2225 Corynebacterium diphtheriae NCTC 13129 fimbrial associated sortase-like protein NP_940532.1 2312860 R 257309 CDS NP_940533.1 38234766 2650025 complement(2314006..2315673) 1 NC_002935.2 Similar to Actinomyces naeslundii fimbrial subunit type 2 precursor SW:FM2_ACTNA (P12616) (534 aa) fasta scores: E(): 1e-30, 38.276% id in 580 aa, and to Actinomyces viscosus fimbrial subunit type 1 precursor SW:FM1_ACTVI (P18477) (533 aa) fasta scores: E(): 7.4e-12, 29.856% id in 556 aa. Note: Contains a potential sortase anchor site (LPLTG) upstream of the C-terminal region transmembrane domain; surface-anchored fimbrial subunit 2315673 2650025 DIP2226 Corynebacterium diphtheriae NCTC 13129 surface-anchored fimbrial subunit NP_940533.1 2314006 R 257309 CDS NP_940534.1 38234767 2650026 complement(2315777..2319904) 1 NC_002935.2 Similar to Actinomyces naeslundii hypothetical 103.4 kDa protein TR:Q9EV17 (EMBL:AJ401093) (976 aa) fasta scores: E(): 0.0003, 29.146% id in 597 aa. Note: Contains a potential sortase anchor site (LPLTG) upstream of the C-terminal region transmembrane domain; surface-anchored fimbrial subunit 2319904 2650026 DIP2227 Corynebacterium diphtheriae NCTC 13129 surface-anchored fimbrial subunit NP_940534.1 2315777 R 257309 CDS NP_940535.1 38234768 2650027 2320038..2320220 1 NC_002935.2 hypothetical protein 2320220 2650027 DIP2228 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940535.1 2320038 D 257309 CDS NP_940536.1 38234769 2650029 2321459..2321896 1 NC_002935.2 hypothetical protein 2321896 2650029 DIP2233 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940536.1 2321459 D 257309 CDS NP_940537.1 38234770 2650030 2322596..2322967 1 NC_002935.2 hypothetical protein 2322967 2650030 DIP2234 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940537.1 2322596 D 257309 CDS NP_940538.1 38234771 2650031 complement(2323066..2324586) 1 NC_002935.2 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 2324586 glpK 2650031 glpK Corynebacterium diphtheriae NCTC 13129 glycerol kinase NP_940538.1 2323066 R 257309 CDS NP_940539.1 38234772 2650032 complement(2324605..2325345) 1 NC_002935.2 Similar to Bacillus subtilis glycerol uptake facilitator protein GlpF SW:GLPF_BACSU (P18156) (274 aa) fasta scores: E(): 2.1e-23, 45.83% id in 240 aa; glycerol uptake facilitator protein 2325345 glpF 2650032 glpF Corynebacterium diphtheriae NCTC 13129 glycerol uptake facilitator protein NP_940539.1 2324605 R 257309 CDS NP_940540.1 38234773 2650033 complement(2325345..2327078) 1 NC_002935.2 Similar to Mycobacterium leprae glycerol-3-phosphate dehydrogenase GlpD or ML0713 or L308_C1_179 SW:GLPD_MYCLE (P53435) (585 aa) fasta scores: E(): 5.7e-116, 55.35% id in 560 aa, and to Escherichia coli aerobic glycerol-3-phosphate dehydrogenase GlpD or GlyD or B3426 SW:GLPD_ECOLI (P13035) (501 aa) fasta scores: E(): 2.4e-38, 33.67% id in 493 aa; glycerol-3-phosphate dehydrogenase 2327078 glpD 2650033 glpD Corynebacterium diphtheriae NCTC 13129 glycerol-3-phosphate dehydrogenase NP_940540.1 2325345 R 257309 CDS NP_940541.1 38234774 2650034 complement(2327266..2329098) 1 NC_002935.2 Similar to Mycobacterium tuberculosis acyltransferase Rv3816c or MTCY409.14 TR:O07807 (EMBL:Z97188) (259 aa) fasta scores: E(): 2.5e-34, 47.6% id in 250 aa, and to Brassica napus lysophosphatidic acid acyltransferase Act2 TR:Q9LLY4 (EMBL:AF111161) (344 aa) fasta scores: E(): 4.3e-06, 29.05% id in 148 aa; acyltransferase 2329098 2650034 DIP2238 Corynebacterium diphtheriae NCTC 13129 acyltransferase NP_940541.1 2327266 R 257309 CDS NP_940542.1 38234775 2650035 complement(2329111..2329938) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 28.5 kDa protein Rv3813c or MTCY409.17 TR:O07810 (EMBL:Z97188) (273 aa) fasta scores: E(): 4.2e-35, 41.69% id in 271 aa, and to Streptomyces coelicolor hypothetical 32.5 kDa protein SCD78.17c TR:Q9ZBY2 (EMBL:AL034355) (305 aa) fasta scores: E(): 2.3e-19, 34.29% id in 277 aa; hypothetical protein 2329938 2650035 DIP2239 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940542.1 2329111 R 257309 CDS NP_940543.1 38234776 2650036 complement(2329968..2331227) 1 NC_002935.2 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 2331227 serS 2650036 serS Corynebacterium diphtheriae NCTC 13129 seryl-tRNA synthetase NP_940543.1 2329968 R 257309 CDS NP_940544.1 38234777 2650037 2331262..2332098 1 NC_002935.2 Similar to Streptomyces coelicolor GntR-family transcriptional regulator SC7E4.28c TR:Q9K492 (EMBL:AL359214) (254 aa) fasta scores: E(): 7.3e-21, 34.82% id in 224 aa, and to Escherichia coli fatty acyl responsive regulator FarR or G30 or B0730 SW:FARR_ECOLI (P13669) (240 aa) fasta scores: E(): 6.4e-14, 30.93% id in 236 aa; GntR family transcriptional regulator 2332098 2650037 DIP2241 Corynebacterium diphtheriae NCTC 13129 GntR family transcriptional regulator NP_940544.1 2331262 D 257309 CDS NP_940545.1 38234778 2650038 2332109..2333101 1 NC_002935.2 Similar to, but shorter than, Mycobacterium tuberculosis hypothetical 47.0 kDa protein Rv3835 or MTCY01A6.34c TR:P96243 (EMBL:Z83864) (449 aa) fasta scores: E(): 6.4e-31, 34.83% id in 310 aa; hypothetical protein 2333101 2650038 DIP2242 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940545.1 2332109 D 257309 CDS NP_940546.1 38234779 2650039 2333108..2333455 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 15.0 kDa protein Rv3836 or MTCY01A6.33c TR:P96242 (EMBL:Z83864) (137 aa) fasta scores: E(): 2.5e-18, 47.78% id in 113 aa, and to Streptomyces coelicolor hypothetical 13.1 kDa protein SCD25.30 TR:Q9RKJ2 (EMBL:AL118514) (116 aa) fasta scores: E(): 5.9e-16, 46.08% id in 115 aa; hypothetical protein 2333455 2650039 DIP2243 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940546.1 2333108 D 257309 CDS NP_940547.1 38234780 2650040 2333530..2334777 1 NC_002935.2 Similar to Mycoplasma fermentans similar to unrecognized orf in the mycobacterium tuberculosis genome sequence TR:Q9RFP6 (EMBL:AF179376) (373 aa) fasta scores: E(): 1.3e-25, 28.99% id in 369 aa, and to Mycobacterium tuberculosis hypothetical 48.1 kDa protein Rv3179 or MT3270 or MTV014.23 TR:O53329 (EMBL:AL021646) (429 aa) fasta scores: E(): 4e-15, 25.53% id in 423 aa; hypothetical protein 2334777 2650040 DIP2244 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940547.1 2333530 D 257309 CDS NP_940548.1 38234781 2650041 complement(2334763..2335407) 1 NC_002935.2 Similar to Mycobacterium leprae phosphoglycerate mutase ML0079 TR:Q9CDC3 (EMBL:AL583917) (231 aa) fasta scores: E(): 4e-11, 33.64% id in 214 aa, and to Schizosaccharomyces pombe phosphoglycerate mutase Gpm1 or SPAC26F1.06 SW:PMGY_SCHPO (P36623) (211 aa) fasta scores: E(): 0.28, 24.4% id in 209 aa; phosphoglycerate mutase 2335407 2650041 DIP2245 Corynebacterium diphtheriae NCTC 13129 phosphoglycerate mutase NP_940548.1 2334763 R 257309 CDS NP_940549.2 161598672 2650042 complement(2335434..2336336) 1 NC_002935.2 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase 2336336 pheA 2650042 pheA Corynebacterium diphtheriae NCTC 13129 prephenate dehydratase NP_940549.2 2335434 R 257309 CDS NP_940550.1 38234783 2650043 2336303..2337508 1 NC_002935.2 Similar to Rhodococcus sp enantiomerase-selective amidase AmdA TR:Q53116 (EMBL:M74531) (462 aa) fasta scores: E(): 6.2e-15, 30.19% id in 414 aa, and to Mycobacterium smegmatis nicotinamidase/pyrazinamidase PzaA TR:Q9ZHK8 (EMBL:AF058285) (468 aa) fasta scores: E(): 6.4e-14, 30.55% id in 360 aa, and to Rhodococcus erythropolis amidase AmdA SW:AMID_RHOER (P22984) (520 aa) fasta scores: E(): 2.8e-11, 33.61% id in 238 aa; amidase 2337508 2650043 DIP2247 Corynebacterium diphtheriae NCTC 13129 amidase NP_940550.1 2336303 D 257309 CDS NP_940551.1 38234784 2650044 2337505..2338221 1 NC_002935.2 Similar to Streptomyces coelicolor integral membrane protein SC10A9.14c TR:Q9AK90 (EMBL:AL583943) (275 aa) fasta scores: E(): 1.6e-17, 41.12% id in 248 aa; integral membrane protein 2338221 2650044 DIP2248 Corynebacterium diphtheriae NCTC 13129 integral membrane protein NP_940551.1 2337505 D 257309 CDS NP_940552.1 38234785 2650045 complement(2338205..2340496) 1 NC_002935.2 Similar to Pseudomonas aeruginosa nitric-oxide reductase subunit B NorB or PA0524 SW:NORB_PSEAE (Q59647) (466 aa) fasta scores: E(): 4e-19, 28.54% id in 494 aa, and to Pseudomonas stutzeri nitric-oxide reductase subunit B NorB SW:NORB_PSEST (P98008) (473 aa) fasta scores: E(): 3.3e-17, 27.18% id in 493 aa; nitric-oxide reductase 2340496 2650045 DIP2249 Corynebacterium diphtheriae NCTC 13129 nitric-oxide reductase NP_940552.1 2338205 R 257309 CDS NP_940553.1 38234786 2650046 2340708..2342003 1 NC_002935.2 Region similar to many eg. Streptomyces coelicolor membrane protein SCBAC19G2.03c TR:CAC44513 (EMBL:AL596138) (397 aa) fasta scores: E(): 4.6e-19, 36.91% id in 409 aa, and to Staphylococcus aureus (strain N315), and SA2103 protein or SAV2310 TR:BAB58472 (EMBL:AP003136) (315 aa) fasta scores: E(): 4.5e-13, 31.07% id in 280 aa; hypothetical protein 2342003 2650046 DIP2250 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940553.1 2340708 D 257309 CDS NP_940554.1 38234787 2650047 complement(2342131..2343621) 1 NC_002935.2 Similar to Vibrio cholerae sodium/alanine symporter Vc0784 TR:Q9KTV3 (EMBL:AE004164) (516 aa) fasta scores: E(): 1.7e-83, 47.34% id in 509 aa, and to Bacillus PS3 sodium/proton-dependent alanine carrier protein Acp SW:ALCP_BACP3 (P30145) (445 aa) fasta scores: E(): 3.9e-58, 46.25% id in 454 aa; sodium/alanine symporter 2343621 2650047 DIP2251 Corynebacterium diphtheriae NCTC 13129 sodium/alanine symporter NP_940554.1 2342131 R 257309 CDS NP_940555.1 38234788 2650048 2343812..2345605 1 NC_002935.2 Similar to Bacillus subtilis hypothetical 72.2 kDa protein YrhL TR:O05402 (EMBL:U93874) (634 aa) fasta scores: E(): 5.9e-41, 31.37% id in 631 aa, and to Streptomyces coelicolor possible integral membrane protein SC8G12.07c TR:Q9KYZ8 (EMBL:AL355753) (418 aa) fasta scores: E(): 2.5e-32, 37.7% id in 419 aa; hypothetical protein 2345605 2650048 DIP2252 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940555.1 2343812 D 257309 CDS NP_940556.1 38234789 2650049 complement(2345667..2346533) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 34.5 kDa protein SCBAC25E3.11c TR:CAC44698 (EMBL:AL596251) (321 aa) fasta scores: E(): 1.1e-27, 36.17% id in 293 aa; hypothetical protein 2346533 2650049 DIP2253 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940556.1 2345667 R 257309 CDS NP_940557.1 38234790 2650050 complement(2346584..2347267) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 29.9 kDa protein GlpQ1 or Rv3842c or MT3950 or MTCY01A6.27 TR:P96236 (EMBL:Z83864) (274 aa) fasta scores: E(): 1e-08, 36.84% id in 247 aa, and to Streptomyces coelicolor phosphodiesterase 2SCG4.06 TR:Q9K3Q8 (EMBL:AL360034) (227 aa) fasta scores: E(): 1.2e-08, 28.5% id in 228 aa; hypothetical protein 2347267 2650050 DIP2254 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940557.1 2346584 R 257309 CDS NP_940558.1 38234791 2650051 complement(2347413..2348369) 1 NC_002935.2 Converts (S)-lactate and NAD(+) to pyruvate and NADH; L-lactate dehydrogenase 2348369 ldh 2650051 ldh Corynebacterium diphtheriae NCTC 13129 L-lactate dehydrogenase NP_940558.1 2347413 R 257309 CDS NP_940559.1 38234792 2650052 complement(2348729..2349454) 1 NC_002935.2 Similar to many eg. Mycobacterium tuberculosis hypothetical 25.9 kDa protein Rv1593c or MT1629 or MTCY336.11 TR:O06597 (EMBL:Z95586) (236 aa) fasta scores: E(): 1.2e-20, 37.28% id in 228 aa. Note possible alternative translational start site; hypothetical protein 2349454 2650052 DIP2256 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940559.1 2348729 R 257309 CDS NP_940560.1 38234793 2650053 2349511..2350428 1 NC_002935.2 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 2350428 nadA 2650053 nadA Corynebacterium diphtheriae NCTC 13129 quinolinate synthetase NP_940560.1 2349511 D 257309 CDS NP_940561.1 38234794 2650054 2350425..2351654 1 NC_002935.2 Member of a large family of including Sulfolobus solfataricus aspartate oxidase NadB or SSO0997 TR:Q97ZC5 (EMBL:AE006719) (487 aa) fasta scores: E(): 1.4e-18, 36.79% id in 405 aa, and to Streptomyces coelicolor L-aspartate oxidase SCE94.33c TR:Q9X8N8 (EMBL:AL049628) (580 aa) fasta scores: E(): 2.1e-15, 39.6% id in 409 aa; aspartate oxidase 2351654 nadB 2650054 nadB Corynebacterium diphtheriae NCTC 13129 aspartate oxidase NP_940561.1 2350425 D 257309 CDS NP_940562.1 38234795 2650055 2351642..2352469 1 NC_002935.2 Similar to Mycobacterium tuberculosis nicotinate-nucleotide pyrophosphorylase [carboxylating] NadC or Rv1596 or MT1632 or MTCY336.08c SWALL:NADC_MYCTU (SWALL:O06594) (285 aa) fasta scores: E(): 2.1e-43, 51.09% id in 274 aa, and to Salmonella typhimurium nicotinate-nucleotide pyrophosphorylase [carboxylating] NadC or STM0145 SWALL:NADC_SALTY (SWALL:P30012) (296 aa) fasta scores: E(): 1.6e-34, 41.17% id in 272 aa; nicotinate-nucleotide pyrophosphorylase 2352469 nadC 2650055 nadC Corynebacterium diphtheriae NCTC 13129 nicotinate-nucleotide pyrophosphorylase NP_940562.1 2351642 D 257309 CDS NP_940563.1 38234796 2650056 complement(2352676..2353338) 1 NC_002935.2 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 2353338 msrA 2650056 msrA Corynebacterium diphtheriae NCTC 13129 methionine sulfoxide reductase A NP_940563.1 2352676 R 257309 CDS NP_940564.1 38234797 2650057 2353492..2354091 1 NC_002935.2 Similar to Corynebacterium melassecola manganese superoxide dismutase SodA SWALL:BAB62412 (EMBL:AF236111) (200 aa) fasta scores: E(): 1.7e-67, 84.26% id in 197 aa. Previously described as Corynebacterium diphtheriae superoxide dismutase [Mn] SodA or Sod SWALL:SODM_CORDI (SWALL:P42821) (162 aa) fasta scores: E(): 1.5e-62, 97.56% id in 164 aa (note difference in translational start); manganese superoxide dismutase 2354091 sodA 2650057 sodA Corynebacterium diphtheriae NCTC 13129 manganese superoxide dismutase NP_940564.1 2353492 D 257309 CDS NP_940565.1 38234798 2650058 2354340..2354876 1 NC_002935.2 Similar to Neisseria meningitidis oxidoreductase NMA0666 SWALL:Q9JVV3 (EMBL:AL162753) (188 aa) fasta scores: E(): 5.4e-42, 62.7% id in 185 aa, and to Pseudomonas putida chromate reductase ChrR SWALL:AAK56853 (EMBL:AF375642) (186 aa) fasta scores: E(): 9.1e-28, 45.19% id in 177 aa, and to Arabidopsis thaliana NADPH:quinone oxidoreductase Nqr SWALL:Q9XFI5 (EMBL:AF145234) (196 aa) fasta scores: E(): 1.7e-11, 36.7% id in 158 aa; oxidoreductase 2354876 2650058 DIP2262 Corynebacterium diphtheriae NCTC 13129 oxidoreductase NP_940565.1 2354340 D 257309 CDS NP_940566.1 38234799 2650059 complement(2354873..2356225) 1 NC_002935.2 Similar to Mycobacterium tuberculosis membrane protein Rv2181 or MTV021.14 SWALL:O53515 (EMBL:AL021957) (427 aa) fasta scores: E(): 1.3e-33, 34.86% id in 370 aa; hypothetical protein 2356225 2650059 DIP2263 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940566.1 2354873 R 257309 CDS NP_940567.1 38234800 2650060 complement(2356239..2357810) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 123.1 kDa protein Rv1251c or MT1290 or MTV006.23c SWALL:O50466 (EMBL:AL021006) (1139 aa) fasta scores: E(): 1.6, 26.47% id in 544 aa; hypothetical protein 2357810 2650060 DIP2264 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940567.1 2356239 R 257309 CDS NP_940568.1 38234801 2650061 2357845..2358555 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 23.8 kDa protein Rv3850 or MTCY01A6.18C SWALL:P96227 (EMBL:Z83864) (218 aa) fasta scores: E(): 7.9e-15, 34.1% id in 217 aa; hypothetical protein 2358555 2650061 DIP2265 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940568.1 2357845 D 257309 CDS NP_940569.1 38234802 2650062 2358677..2358994 1 NC_002935.2 Similar to Streptomyces coelicolor Lsr2-like protein SCD25.12c SWALL:Q9RKK8 (EMBL:AL118514) (105 aa) fasta scores: E(): 1.1e-08, 39.04% id in 105 aa, and to Mycobacterium leprae Lsr2 protein precursor or ML0234 SWALL:LSR2_MYCLE (SWALL:P24094) (112 aa) fasta scores: E(): 2.4, 26.95% id in 115 aa; hypothetical protein 2358994 2650062 DIP2266 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940569.1 2358677 D 257309 CDS NP_940570.1 38234803 2650063 complement(2359054..2359692) 1 NC_002935.2 Similar to Streptomyces coelicolor two component system DNA binding response regulator SC10A9.12 SWALL:Q9AK92 (EMBL:AL583943) (211 aa) fasta scores: E(): 7.7e-38, 59.24% id in 211 aa, and to Corynebacterium diphtheriae response regulator ChrA (DIP2327) SWALL:Q9RPE9 (EMBL:AF161327) (199 aa) fasta scores: E(): 2.1e-21, 49.76% id in 209 aa; two component system response regulator protein 2359692 2650063 DIP2267 Corynebacterium diphtheriae NCTC 13129 two component system response regulator protein NP_940570.1 2359054 R 257309 CDS NP_940571.1 38234804 2650064 complement(2359774..2361153) 1 NC_002935.2 Similar to Streptomyces coelicolor two component system histidine kinase SC10A9.11 SWALL:Q9AK93 (EMBL:AL583943) (404 aa) fasta scores: E(): 7.7e-36, 37.15% id in 401 aa, and to Corynebacterium diphtheriae histidine kinase ChrS (DIP2326) SWALL:Q9RPF0 (EMBL:AF161327) (417 aa) fasta scores: E(): 8.2e-25, 31.17% id in 401 aa; two component system histidine kinase 2361153 2650064 DIP2268 Corynebacterium diphtheriae NCTC 13129 two component system histidine kinase NP_940571.1 2359774 R 257309 CDS NP_940572.1 38234805 2650065 2361176..2361622 1 NC_002935.2 hypothetical protein 2361622 2650065 DIP2269 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940572.1 2361176 D 257309 CDS NP_940573.1 38234806 2650066 2361757..2363166 1 NC_002935.2 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter 2363166 uhpT 2650066 uhpT Corynebacterium diphtheriae NCTC 13129 sugar phosphate antiporter NP_940573.1 2361757 D 257309 CDS NP_940574.1 38234807 2650067 complement(2363229..2363381) 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 8.0 kDa protein SCH69.22c SWALL:Q9XA12 (EMBL:AL079308) (69 aa) fasta scores: E(): 1.3e-05, 40% id in 50 aa; hypothetical protein 2363381 2650067 DIP2271 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940574.1 2363229 R 257309 CDS NP_940575.1 38234808 2650068 complement(2363388..2364209) 1 NC_002935.2 Similar to Clostridium acetobutylicum sortase CAC0204 TR:AAK78186 (EMBL:AE007533) (194 aa) fasta scores: E(): 2.6e-06, 30.872% id in 149 aa, and weakly similar to Actinomyces naeslundii fimbria-associated protein TR:O68213 (EMBL:AF019629) (365 aa) fasta scores: E(): 0.25, 32.941% id in 85 aa, and to Streptococcus pneumoniae TIGR4 sortase, SP0466 TR:AAK74626 (EMBL:AE007358) (279 aa) fasta scores: E(): 5.3, 25.000% id in 144 aa; sortase 2364209 2650068 DIP2272 Corynebacterium diphtheriae NCTC 13129 sortase NP_940575.1 2363388 R 257309 CDS NP_940576.1 38234809 2650069 2364341..2365648 1 NC_002935.2 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 2365648 2650069 DIP2273 Corynebacterium diphtheriae NCTC 13129 inner membrane protein translocase component YidC NP_940576.1 2364341 D 257309 CDS NP_940577.1 38234810 2650070 complement(2365515..2366141) 1 NC_002935.2 Similar to many eg. Streptomyces coelicolor transcriptional regulator SCD6.32c SWALL:Q9KZX2 (EMBL:AL353815) (200 aa) fasta scores: E(): 8.4e-15, 36.72% id in 177 aa; TetR family transcriptional regulator 2366141 2650070 DIP2274 Corynebacterium diphtheriae NCTC 13129 TetR family transcriptional regulator NP_940577.1 2365515 R 257309 CDS NP_940578.1 38234811 2650071 complement(2366430..2366693) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 10.3 kDa protein Rv1861 or MTCY359.12c SWALL:P95154 (EMBL:Z83859) (101 aa) fasta scores: E(): 1.6e-10, 47.72% id in 88 aa, and to Escherichia coli transglycosylase associated protein YmgE or Tag or B1195 SWALL:TAG1_ECOLI (SWALL:P76011) (84 aa) fasta scores: E(): 2.5e-05, 38.82% id in 85 aa; hypothetical protein 2366693 2650071 DIP2275 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940578.1 2366430 R 257309 CDS NP_940579.1 38234812 2650072 complement(2366976..2367878) 1 NC_002935.2 Similar to many including predicted universal stress proteins eg. Mycobacterium tuberculosis hypothetical 30.9 kDa protein Rv2005c or MT2061 or MTCY39.12 SWALL:YK05_MYCTU (SWALL:Q10851) (295 aa) fasta scores: E(): 1.7e-32, 40.87% id in 296 aa, and to Mycobacterium tuberculosis CDC1551 universal stress protein family MT2698 SWALL:AAK47014 (EMBL:AE007102) (297 aa) fasta scores: E(): 1.7e-30, 36.73% id in 294 aa; hypothetical protein 2367878 2650072 DIP2276 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940579.1 2366976 R 257309 CDS NP_940580.1 38234813 2650073 2368117..2369166 1 NC_002935.2 Similar to hypothetical proteins and proposed ribosomal pseudouridine synthases eg. Mycobacterium tuberculosis hypothetical 33.3 kDa protein Rv3300c or MT3399 or MTCI418A.02c SWALL:O07166 (EMBL:Z96070) (305 aa) fasta scores: E(): 6.3e-23, 45.74% id in 247 aa, and to Streptomyces coelicolor ribosomal pseudouridine synthase SCI41.08 SWALL:Q9RJ76 (EMBL:AL132648) (324 aa) fasta scores: E(): 1.9e-22, 40.69% id in 317 aa; hypothetical protein 2369166 2650073 DIP2277 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940580.1 2368117 D 257309 CDS NP_940581.1 38234814 2650077 complement(2375291..2376304) 1 NC_002935.2 No significant database matches. Lies downstream of a ABC transporter ATP-binding subunit; integral membrane protein 2376304 2650077 DIP2278 Corynebacterium diphtheriae NCTC 13129 integral membrane protein NP_940581.1 2375291 R 257309 CDS NP_940582.1 38234815 2650078 complement(2376306..2377175) 1 NC_002935.2 Similar to many eg. Bacillus halodurans ABC transporter BH3493 SWALL:Q9K777 (EMBL:AP001519) (283 aa) fasta scores: E(): 3.8e-18, 33.97% id in 209 aa, and to Bacillus subtilis hypothetical ABC transporter ATP-binding protein YhcG SWALL:YHCG_BACSU (SWALL:P54591) (232 aa) fasta scores: E(): 4.1e-12, 31.01% id in 216 aa; ABC transporter ATP-binding protein 2377175 2650078 DIP2279 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_940582.1 2376306 R 257309 CDS NP_940583.1 38234816 2650079 complement(2377172..2377558) 1 NC_002935.2 Similar to many eg. Bacillus halodurans transcriptional regulator BH3492 SWALL:Q9K778 (EMBL:AP001519) (129 aa) fasta scores: E(): 6.6e-15, 43.36% id in 113 aa; GntR family transcriptional regulator 2377558 2650079 DIP2280 Corynebacterium diphtheriae NCTC 13129 GntR family transcriptional regulator NP_940583.1 2377172 R 257309 CDS NP_940584.1 38234817 2650080 2377787..2379163 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 44.0 kDa protein SC4G6.31c SWALL:Q9S2S7 (EMBL:AL096884) (403 aa) fasta scores: E(): 4.6e-09, 25.49% id in 459 aa; hypothetical protein 2379163 2650080 DIP2281 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940584.1 2377787 D 257309 CDS NP_940585.1 38234818 2650081 complement(2379236..2380000) 1 NC_002935.2 Similar to Mycobacterium tuberculosis 35 kDa protein Rv2744c or MT2815 or MTV002.09c SWALL:35KD_MYCTU (SWALL:P31511) (270 aa) fasta scores: E(): 8.4e-29, 45.52% id in 257 aa; hypothetical protein 2380000 2650081 DIP2282 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940585.1 2379236 R 257309 CDS NP_940586.1 38234819 2650082 complement(2380171..2380554) 1 NC_002935.2 Similar to Streptomyces coelicolor thioredoxin TrxA2 SWALL:Q9RD25 (EMBL:AL133422) (134 aa) fasta scores: E(): 1.7e-23, 52.89% id in 121 aa, and to Escherichia coli thioredoxin 2 TrxC or B2582 or Z3867 or ECS3448 SWALL:THI2_ECOLI (SWALL:P33636) (139 aa) fasta scores: E(): 5.9e-11, 38% id in 100 aa; thioredoxin 2380554 2650082 DIP2284 Corynebacterium diphtheriae NCTC 13129 thioredoxin NP_940586.1 2380171 R 257309 CDS NP_940587.1 38234820 2650083 2380762..2380971 1 NC_002935.2 Similar to Streptomyces coelicolor metal associated protein SCG20A.25 SWALL:Q9K3L5 (EMBL:AL360055) (77 aa) fasta scores: E(): 1.3e-05, 45.9% id in 61 aa, and to Helicobacter felis cop associated protein CopP SWALL:COPP_HELFE (SWALL:O32620) (66 aa) fasta scores: E(): 0.0074, 36.92% id in 65 aa; cation transport protein 2380971 2650083 DIP2285 Corynebacterium diphtheriae NCTC 13129 cation transport protein NP_940587.1 2380762 D 257309 CDS NP_940588.1 38234821 2650084 2381127..2383358 1 NC_002935.2 Similar to Streptomyces coelicolor probable cation-transporting P-type ATPase SCC57A.02 SWALL:Q9RDJ4 (EMBL:AL136519) (760 aa) fasta scores: E(): 7e-146, 60.21% id in 744 aa, and to Rhizobium meliloti copper-transporting ATPase ActP SWALL:ATCU_RHIME (SWALL:Q9X5X3) (827 aa) fasta scores: E(): 1.3e-84, 42.12% id in 762 aa; cation-transporting P-type ATPase 2383358 2650084 DIP2286 Corynebacterium diphtheriae NCTC 13129 cation-transporting P-type ATPase NP_940588.1 2381127 D 257309 CDS NP_940589.1 38234822 2650085 2383456..2384781 1 NC_002935.2 Similar to Deinococcus radiodurans sugar transporter, DRA0271 SWALL:Q9RYN9 (EMBL:AE001863) (454 aa) fasta scores: E(): 9.2e-54, 41.12% id in 445 aa, and to Pseudomonas putida 4-hydroxybenzoate transporter PcaK SWALL:PCAK_PSEPU (SWALL:Q51955) (448 aa) fasta scores: E(): 1.8e-25, 30.4% id in 398 aa; integral membrane transport protein 2384781 2650085 DIP2287 Corynebacterium diphtheriae NCTC 13129 integral membrane transport protein NP_940589.1 2383456 D 257309 CDS NP_940590.1 38234823 2648662 complement(2384785..2386305) 1 NC_002935.2 unwinds double stranded DNA; replicative DNA helicase 2386305 dnaB 2648662 dnaB Corynebacterium diphtheriae NCTC 13129 replicative DNA helicase NP_940590.1 2384785 R 257309 CDS NP_940591.1 38234824 2649123 complement(2386879..2387331) 1 NC_002935.2 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 2387331 rplI 2649123 rplI Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L9 NP_940591.1 2386879 R 257309 CDS NP_940592.1 38234825 2649124 complement(2387462..2388043) 1 NC_002935.2 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 2388043 ssb1 2649124 ssb1 Corynebacterium diphtheriae NCTC 13129 single-stranded DNA-binding protein NP_940592.1 2387462 R 257309 CDS NP_940593.2 161598671 2649125 complement(2388168..2388455) 1 NC_002935.2 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 2388455 rpsF 2649125 rpsF Corynebacterium diphtheriae NCTC 13129 30S ribosomal protein S6 NP_940593.2 2388168 R 257309 CDS NP_940594.1 38234827 2649126 complement(2388650..2388829) 1 NC_002935.2 hypothetical protein 2388829 2649126 DIP2292 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940594.1 2388650 R 257309 CDS NP_940595.1 38234828 2649127 complement(2388829..2390400) 1 NC_002935.2 Similar to Streptomyces coelicolor transmembrane protein SCH24.24 SWALL:Q9X8T8 (EMBL:AL049826) (502 aa) fasta scores: E(): 7.8e-37, 36.2% id in 453 aa; hypothetical protein 2390400 2649127 DIP2293 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940595.1 2388829 R 257309 CDS NP_940596.1 38234829 2649128 complement(2390445..2392625) 1 NC_002935.2 Similar to Mycobacterium smegmatis penicillin-binding protein 1 PonA SWALL:Q9F9V7 (EMBL:AF165523) (715 aa) fasta scores: E(): 4.1e-105, 51.23% id in 689 aa, and to Bacillus subtilis penicillin-binding protein 1A/1B PonA SWALL:PBPA_BACSU (SWALL:P39793) (914 aa) fasta scores: E(): 1.4e-32, 29.44% id in 720 aa; penicillin-binding protein 2392625 2649128 DIP2294 Corynebacterium diphtheriae NCTC 13129 penicillin-binding protein NP_940596.1 2390445 R 257309 CDS NP_940597.1 38234830 2649129 complement(2392713..2393075) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 15.0 kDa protein Rv0049 or MT0055 or MTCY21D4.12 SWALL:Y049_MYCTU (SWALL:P71706) (137 aa) fasta scores: E(): 1e-15, 47.52% id in 101 aa; hypothetical protein 2393075 2649129 DIP2295 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940597.1 2392713 R 257309 CDS NP_940598.1 38234831 2649130 2393194..2393646 1 NC_002935.2 Similar to Mycobacterium tuberculosis CDC1551 transcriptional regulator, MarR family MT0048 SWALL:AAK44270 (EMBL:AE006918) (208 aa) fasta scores: E(): 1.9e-07, 34.72% id in 144 aa, and to Streptomyces coelicolor MarR-family transcriptional regulator SC6D11.20 SWALL:Q9L135 (EMBL:AL158061) (155 aa) fasta scores: E(): 4.7e-05, 33.05% id in 121 aa; MarR family transcriptional regulator 2393646 2649130 DIP2296 Corynebacterium diphtheriae NCTC 13129 MarR family transcriptional regulator NP_940598.1 2393194 D 257309 CDS NP_940599.1 38234832 2649131 2393656..2394621 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 31.9 kDa protein Rv2319c or MT2382 or MTCY3G12.15 SWALL:YN19_MYCTU (SWALL:P71893) (292 aa) fasta scores: E(): 4.3e-21, 28% id in 300 aa; hypothetical protein 2394621 2649131 DIP2297 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940599.1 2393656 D 257309 CDS NP_940600.1 38234833 2649132 2394633..2395304 1 NC_002935.2 Similar to Bacillus subtilis hypothetical oxidoreductase YoxD SWALL:YOXD_BACSU (SWALL:P14802) (238 aa) fasta scores: E(): 2.2e-09, 28.57% id in 231 aa, and to Rhizobium sp short-chain type dehydrogenase/reductase SWALL:Y4EK_RHISN (SWALL:P55434) (248 aa) fasta scores: E(): 2.3e-09, 30% id in 210 aa; short chain dehydrogenase 2395304 2649132 DIP2298 Corynebacterium diphtheriae NCTC 13129 short chain dehydrogenase NP_940600.1 2394633 D 257309 CDS NP_940601.1 38234834 2650407 2395316..2395789 1 NC_002935.2 hypothetical protein 2395789 2650407 DIP2299 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940601.1 2395316 D 257309 CDS NP_940602.1 38234835 2650408 complement(2395856..2397301) 1 NC_002935.2 Regions similar to Pyrococcus abyssi hypothetical 32.8 kDa protein PAB0790 SWALL:Q9UZG6 (EMBL:AJ248286) (287 aa) fasta scores: E(): 1.4e-09, 27.45% id in 306 aa, and to Thiobacillus ferrooxidans ATP-dependent DNA helicase RecG SWALL:RECG_THIFE (SWALL:O50224) (652 aa) fasta scores: E(): 1.9e-07, 30.04% id in 223 aa; DNA-binding protein 2397301 2650408 DIP2300 Corynebacterium diphtheriae NCTC 13129 DNA-binding protein NP_940602.1 2395856 R 257309 CDS NP_940603.1 38234836 2650409 complement(2397459..2398397) 1 NC_002935.2 Similar to Staphylococcus aureus (strain N315) conserved hypothetical protein SA2481 or SAV2689 SWALL:Q99QV2 (EMBL:AP003138) (318 aa) fasta scores: E(): 3.6e-25, 34.68% id in 297 aa; hypothetical protein 2398397 2650409 DIP2301 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940603.1 2397459 R 257309 CDS NP_940604.1 38234837 2650410 2398584..2399222 1 NC_002935.2 Similar to Streptomyces coelicolor integral membrane protein SC4A9.02c SWALL:Q9L1W0 (EMBL:AL138668) (231 aa) fasta scores: E(): 8.7e-31, 41.5% id in 200 aa; hypothetical protein 2399222 2650410 DIP2302 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940604.1 2398584 D 257309 CDS NP_940605.1 38234838 2650411 complement(2399360..2399845) 1 NC_002935.2 Similar to Haemophilus ducreyi fine tangled pili major subunit FtpA SWALL:FTPA_HAEDU (SWALL:Q47953) (189 aa) fasta scores: E(): 3.5e-23, 46.83% id in 158 aa, and to Escherichia coli DNA protection during starvation protein Dps or Pexb or Vtm or B0812 or Z1034 or ECS0890 SWALL:DPS_ECOLI (SWALL:P27430) (166 aa) fasta scores: E(): 1.6e-14, 38.31% id in 154 aa; DNA protection during starvation protein 2399845 2650411 DIP2303 Corynebacterium diphtheriae NCTC 13129 DNA protection during starvation protein NP_940605.1 2399360 R 257309 CDS NP_940606.1 38234839 2650412 2399933..2400787 1 NC_002935.2 Similar to Streptomyces coelicolor DNA repair hydrolase SCC80.11c SWALL:Q9F308 (EMBL:AL442143) (306 aa) fasta scores: E(): 1.1e-52, 53.22% id in 295 aa, and to Escherichia coli formamidopyrimidine-DNA glycosylase MutM or Fpg or B3635 SWALL:FPG_ECOLI (SWALL:P05523) (269 aa) fasta scores: E(): 1.2e-12, 29.21% id in 243 aa; DNA repair glycosylase 2400787 2650412 DIP2304 Corynebacterium diphtheriae NCTC 13129 DNA repair glycosylase NP_940606.1 2399933 D 257309 CDS NP_940607.1 38234840 2650413 2400809..2402317 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 46.9 kDa protein Rv3433c or MT3539 or MTCY77.05c SWALL:YY33_MYCTU (SWALL:O06250) (473 aa) fasta scores: E(): 1.8e-30, 41.96% id in 510 aa; hypothetical protein 2402317 2650413 DIP2305 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940607.1 2400809 D 257309 CDS NP_940608.1 38234841 2650414 complement(2402330..2403466) 1 NC_002935.2 Similar to Saccharopolyspora erythraea lysozyme SWALL:O33985 (EMBL:U82823) (241 aa) fasta scores: E(): 1.3e-23, 36.9% id in 233 aa, and to Clostridium acetobutylicum autolytic lysozyme Lyc or CAC0554 SWALL:LYC_CLOAB (SWALL:P34020) (324 aa) fasta scores: E(): 4.7e-10, 28.27% id in 191 aa; hydrolase 2403466 2650414 DIP2306 Corynebacterium diphtheriae NCTC 13129 hydrolase NP_940608.1 2402330 R 257309 CDS NP_940609.1 38234842 2650415 complement(2403526..2404152) 1 NC_002935.2 hypothetical protein 2404152 2650415 DIP2307 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940609.1 2403526 R 257309 CDS NP_940610.1 38234843 2650416 complement(2404326..2405387) 1 NC_002935.2 Similar to proteins associated with plasmid replication-partitioning eg. Plesiomonas shigelloides hypothetical SoJ-like protein Soj SWALL:Q9RLE7 (EMBL:AJ249644) (182 aa) fasta scores: E(): 1.8e-05, 29.31% id in 191 aa, and to Pseudomonas fluorescens ParA protein SWALL:Q9RLI2 (EMBL:AJ250853) (394 aa) fasta scores: E(): 3.4e-05, 28.77% id in 212 aa, and to Thermus thermophilus partitioning protein ParA/Soj SWALL:Q9LCY1 (EMBL:AJ277593) (248 aa) fasta scores: E(): 0.00017, 31.63% id in 196 aa, and to Lactobacillus reuteri replication-associated protein A RepA SWALL:O52364 (EMBL:AF036766) (295 aa) fasta scores: E(): 0.00042, 28.91% id in 211 aa; hypothetical protein 2405387 2650416 DIP2308 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940610.1 2404326 R 257309 CDS NP_940611.1 38234844 2649133 complement(2405722..2406678) 1 NC_002935.2 DNA-binding protein 2406678 2649133 DIP2309 Corynebacterium diphtheriae NCTC 13129 DNA-binding protein NP_940611.1 2405722 R 257309 CDS NP_940612.1 38234845 2649134 complement(2406782..2407360) 1 NC_002935.2 Similar to N-terminal half of Pyrococcus abyssi hypothetical 48.8 kDa protein Pab1002 SWALL:Q9UYK0 (EMBL:AJ248287) (428 aa) fasta scores: E(): 0.081, 30.05% id in 193 aa; hypothetical protein 2407360 2649134 DIP2310 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940612.1 2406782 R 257309 CDS NP_940613.1 38234846 2649135 complement(2407563..2409290) 1 NC_002935.2 Similar to Deinococcus radiodurans ATP-dependent DNA helicase RecG-related protein DR2199 SWALL:Q9RSC6 (EMBL:AE002053) (596 aa) fasta scores: E(): 1.1e-09, 27.17% id in 574 aa, and to Thiobacillus ferrooxidans ATP-dependent DNA helicase RecG SWALL:RECG_THIFE (SWALL:O50224) (652 aa) fasta scores: E(): 7.7e-05, 33.08% id in 133 aa; hypothetical protein 2409290 2649135 DIP2311 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940613.1 2407563 R 257309 CDS NP_940614.1 38234847 2649136 complement(2409373..2412573) 1 NC_002935.2 Similar to Pasteurella haemolytica HsdR SWALL:P95512 (EMBL:U46781) (1055 aa) fasta scores: E(): 1.4e-61, 34.88% id in 1055 aa; type I restriction/modification system protein 2412573 2649136 DIP2312 Corynebacterium diphtheriae NCTC 13129 type I restriction/modification system protein NP_940614.1 2409373 R 257309 CDS NP_940615.1 38234848 2649137 complement(2412566..2413810) 1 NC_002935.2 Similar to Lactococcus lactis HsdS subunit SWALL:O68173 (EMBL:AF013596) (395 aa) fasta scores: E(): 2.7e-13, 33.72% id in 172 aa, and to Streptococcus thermophilus type I S-subunit protein HsdS SWALL:O52188 (EMBL:AF027167) (412 aa) fasta scores: E(): 1.6e-12, 27.84% id in 334 aa; type I restriction/modification system DNA specificity protein 2413810 2649137 DIP2313 Corynebacterium diphtheriae NCTC 13129 type I restriction/modification system DNA specificity protein NP_940615.1 2412566 R 257309 CDS NP_940616.1 38234849 2649138 complement(2413807..2415414) 1 NC_002935.2 Similar to Klebsiella pneumoniae HsdM SWALL:O34139 (EMBL:U93843) (539 aa) fasta scores: E(): 6.2e-66, 45.37% id in 551 aa, and to Pasteurella multocida HsdM or PM1537 SWALL:Q9CKR9 (EMBL:AE006190) (568 aa) fasta scores: E(): 2e-51, 44.38% id in 561 aa; type I restriction/modification system DNA methylase 2415414 2649138 DIP2314 Corynebacterium diphtheriae NCTC 13129 type I restriction/modification system DNA methylase NP_940616.1 2413807 R 257309 CDS NP_940617.1 38234850 2649139 complement(2415495..2417453) 1 NC_002935.2 DNA-binding protein 2417453 2649139 DIP2315 Corynebacterium diphtheriae NCTC 13129 DNA-binding protein NP_940617.1 2415495 R 257309 CDS NP_940618.1 38234851 2649140 complement(2417717..2418952) 1 NC_002935.2 Similar to Arthrobacter keyseri hypothetical 45.9 kDa protein TnpX SWALL:Q9AGM1 (EMBL:AF331043) (421 aa) fasta scores: E(): 9.4e-26, 33.86% id in 378 aa, and to Agrobacterium tumefaciens STRC58 AGR_PAT_51p SWALL:AAK90413 (EMBL:AE007876) (393 aa) fasta scores: E(): 1.9e-19, 29.67% id in 374 aa; DNA-binding protein 2418952 2649140 DIP2317 Corynebacterium diphtheriae NCTC 13129 DNA-binding protein NP_940618.1 2417717 R 257309 CDS NP_940619.1 38234852 2649141 complement(2419180..2420880) 1 NC_002935.2 Similar to Vibrio cholerae hypothetical protein VCA0786 SWALL:Q9KLF8 (EMBL:AE004407) (549 aa) fasta scores: E(): 1.3e-63, 42.28% id in 570 aa, and to Aeropyrum pernix hypothetical 61.1 kDa protein APE1810 ape1810 SWALL:Q9YAY5 (EMBL:AP000062) (558 aa) fasta scores: E(): 1.5e-39, 33.5% id in 570 aa; hypothetical protein 2420880 2649141 DIP2318 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940619.1 2419180 R 257309 CDS NP_940620.1 38234853 2649142 complement(2420959..2421561) 1 NC_002935.2 Similar to Mycobacterium paratuberculosis copper zinc superoxide dismutase SodC SWALL:Q9AGW2 (EMBL:AF326234) (226 aa) fasta scores: E(): 1.4e-18, 41.36% id in 220 aa, and to Caulobacter crescentus superoxide dismutase [Cu-Zn] precursor SodC or CC1579 SWALL:SODC_CAUCR (SWALL:P20379) (174 aa) fasta scores: E(): 2e-12, 35.13% id in 185 aa; copper zinc superoxide dismutase 2421561 2649142 DIP2319 Corynebacterium diphtheriae NCTC 13129 copper zinc superoxide dismutase NP_940620.1 2420959 R 257309 CDS NP_940621.1 38234854 2649143 complement(2421946..2424828) 1 NC_002935.2 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 2424828 leuS 2649143 leuS Corynebacterium diphtheriae NCTC 13129 leucyl-tRNA synthetase NP_940621.1 2421946 R 257309 CDS NP_940622.1 38234855 2649144 complement(2424897..2425046) 1 NC_002935.2 Doubtful CDS. No significant database matches; hypothetical protein 2425046 2649144 DIP2321 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940622.1 2424897 R 257309 CDS NP_940623.1 38234856 2649145 complement(2425110..2425832) 1 NC_002935.2 hypothetical protein 2425832 2649145 DIP2322 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940623.1 2425110 R 257309 CDS NP_940624.1 38234857 2649146 complement(2425889..2426554) 1 NC_002935.2 Similar to Streptomyces coelicolor ABC transport system ATP-binding protein SC10A9.09c SWALL:Q9AK95 (EMBL:AL583943) (251 aa) fasta scores: E(): 4.7e-31, 51.35% id in 222 aa; ABC transporter ATP-binding protein 2426554 2649146 DIP2323 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_940624.1 2425889 R 257309 CDS NP_940625.1 38234858 2649147 complement(2426551..2427585) 1 NC_002935.2 Similar to Streptomyces coelicolor ABC transport system transmembrane protein SC10A9.10c SWALL:Q9AK94 (EMBL:AL583943) (379 aa) fasta scores: E(): 4.3e-17, 38.94% id in 380 aa. Lies alongside a ABC transporter ATP-binding subunit; ABC transporter inner membrane protein 2427585 2649147 DIP2324 Corynebacterium diphtheriae NCTC 13129 ABC transporter inner membrane protein NP_940625.1 2426551 R 257309 CDS NP_940626.1 38234859 2649148 complement(2427721..2430360) 1 NC_002935.2 No significant database matches. Note: Contains a potential sortase anchor site (LAETG) upstream of the C-terminal region transmembrane domain. Also similar to DIP0439, DIP1724, DIP0442 and DIP0443; surface-anchored protein 2430360 2649148 DIP2325 Corynebacterium diphtheriae NCTC 13129 surface-anchored protein NP_940626.1 2427721 R 257309 CDS NP_940627.1 38234860 2649149 2430452..2431705 1 NC_002935.2 Previously sequenced and described as Corynebacterium diphtheriae histidine kinase ChrS SWALL:Q9RPF0 (EMBL:AF161327) (417 aa) fasta scores: E(): 4e-136, 88.72% id in 417 aa. Similar to many eg. Streptomyces reticuli histidine autokinase SenS SWALL:Q9RIM1 (EMBL:Y14336) (398 aa) fasta scores: E(): 1.6e-21, 35.28% id in 411 aa; two-component system histidine kinase ChrS 2431705 chrS 2649149 chrS Corynebacterium diphtheriae NCTC 13129 two-component system histidine kinase ChrS NP_940627.1 2430452 D 257309 CDS NP_940628.1 38234861 2649150 2431702..2432301 1 NC_002935.2 Previously sequenced and described as Corynebacterium diphtheriae response regulator ChrA SWALL:Q9RPE9 (EMBL:AF161327) (199 aa) fasta scores: E(): 2.7e-67, 98.49% id in 199 aa. Similar to many eg. Streptomyces reticuli response regulatory protein SenR SWALL:Q9RIM0 (EMBL:Y14336) (217 aa) fasta scores: E(): 1.5e-28, 49.51% id in 204 aa; two-component response regulator ChrA 2432301 chrA 2649150 chrA Corynebacterium diphtheriae NCTC 13129 two-component response regulator ChrA NP_940628.1 2431702 D 257309 CDS NP_940629.1 38234862 2649151 complement(2432298..2432843) 1 NC_002935.2 Similar to Clostridium acetobutylicum uncharacterized conserved membrane protein, similar to Mdr CAC0829 SWALL:AAK78805 (EMBL:AE007599) (308 aa) fasta scores: E(): 0.0003, 25.88% id in 170 aa, and has region in common with Enterococcus faecium protein VanZ SWALL:VANZ_ENTFC (SWALL:Q06242) (161 aa) fasta scores: E(): 0.19, 29.16% id in 96 aa; integral membrane protein 2432843 2649151 DIP2328 Corynebacterium diphtheriae NCTC 13129 integral membrane protein NP_940629.1 2432298 R 257309 CDS NP_940630.1 38234863 2649152 complement(2432940..2434841) 1 NC_002935.2 Weak but full length similarity to many eg. Clostridium acetobutylicum uncharacterized conserved membrane protein, YhgE B.subtilis ortholog CAC3589 SWALL:AAK81512 (EMBL:AE007855) (783 aa) fasta scores: E(): 1.6e-16, 23.62% id in 766 aa; hypothetical protein 2434841 2649152 DIP2329 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940630.1 2432940 R 257309 CDS NP_940631.1 38234864 2649153 2435213..2436271 1 NC_002935.2 No significant database matches. Lies in DNA region of low GC content.; hypothetical protein 2436271 2649153 DIP2330 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940631.1 2435213 D 257309 CDS NP_940632.1 38234865 2649154 2436460..2437851 1 NC_002935.2 Similar to Deinococcus radiodurans succinate-semialdehyde dehydrogenase [NADP+] SsdA or DRA0343 SWALL:GABD_DEIRA (SWALL:O32507) (477 aa) fasta scores: E(): 1.2e-81, 49.44% id in 453 aa, and to Streptomyces coelicolor aldehyde dehydrogenase 2SCG58.04 SWALL:Q9FCA9 (EMBL:AL391017) (461 aa) fasta scores: E(): 4.1e-65, 42.57% id in 458 aa, and to Ustilago maydis indole-3-acetaldehyde dehydrogenase Iad1 SWALL:Q92460 (EMBL:U74468) (497 aa) fasta scores: E(): 1.6e-48, 37.04% id in 467 aa; aldehyde dehydrogenase 2437851 2649154 DIP2331 Corynebacterium diphtheriae NCTC 13129 aldehyde dehydrogenase NP_940632.1 2436460 D 257309 CDS NP_940633.1 38234866 2649155 2438019..2438813 1 NC_002935.2 Similar to Streptomyces coelicolor hypothetical 17.6 kDa protein SCJ21.18C SWALL:Q9S1Y9 (EMBL:AL109747) (170 aa) fasta scores: E(): 3e-29, 56.97% id in 172 aa, and to Escherichia coli unknown pentitol II, A component SgaA or B4195 or Z5804 or ECS5171 SWALL:PTXA_ECOLI (SWALL:P39303) (154 aa) fasta scores: E(): 1.3e-12, 39.82% id in 113 aa; phosphotransferase system protein 2438813 2649155 DIP2332 Corynebacterium diphtheriae NCTC 13129 phosphotransferase system protein NP_940633.1 2438019 D 257309 CDS NP_940634.1 38234867 2649156 2438839..2440401 1 NC_002935.2 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 2440401 ulaA 2649156 ulaA Corynebacterium diphtheriae NCTC 13129 PTS system ascorbate-specific transporter subunit IIC NP_940634.1 2438839 D 257309 CDS NP_940635.1 38234868 2649157 2440685..2441680 1 NC_002935.2 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 2441680 2649157 DIP2334 Corynebacterium diphtheriae NCTC 13129 dihydroxyacetone kinase subunit DhaK NP_940635.1 2440685 D 257309 CDS NP_940636.1 38234869 2649158 2441684..2442325 1 NC_002935.2 Similar to Selenomonas ruminantium subspruminantium dihydroxyacetone kinase Dhak2 SWALL:AAG14892 (EMBL:AF297121) (207 aa) fasta scores: E(): 6.6e-25, 48.51% id in 202 aa, and to Escherichia coli protein YcgS or B1199 SWALL:YCGS_ECOLI (SWALL:P76014) (210 aa) fasta scores: E(): 2e-22, 43.12% id in 211 aa. Lies downstream of a Dhak1 homologue; dihydroxyacetone kinase sununit 2442325 2649158 DIP2335 Corynebacterium diphtheriae NCTC 13129 dihydroxyacetone kinase sununit NP_940636.1 2441684 D 257309 CDS NP_940637.1 38234870 2649159 2442322..2442990 1 NC_002935.2 Similar to but longer than a family of hypothetical proteins eg. Deinococcus radiodurans conserved hypothetical protein DRB0052 SWALL:Q9RZR3 (EMBL:AE001826) (133 aa) fasta scores: E(): 8.8e-10, 43.75% id in 128 aa, and to Staphylococcus aureus (strain N315) hypothetical protein SA0607 or SAV0652 SWALL:Q99VW9 (EMBL:AP003131) (120 aa) fasta scores: E(): 1.3e-09, 42.73% id in 117 aa; hypothetical protein 2442990 2649159 DIP2336 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940637.1 2442322 D 257309 CDS NP_940638.1 38234871 2649160 2443176..2444495 1 NC_002935.2 Similar to Lactococcus lactis abortive phage resistance protein AbilI SWALL:O06042 (EMBL:U94520) (458 aa) fasta scores: E(): 7.4e-08, 26.39% id in 466 aa. Lies in DNA region of low GC content.; phage resistance protein 2444495 2649160 DIP2337 Corynebacterium diphtheriae NCTC 13129 phage resistance protein NP_940638.1 2443176 D 257309 CDS NP_940639.1 38234872 2649161 2444518..2445123 1 NC_002935.2 hypothetical protein 2445123 2649161 DIP2338 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940639.1 2444518 D 257309 CDS NP_940640.1 38234873 2649162 complement(2445460..2446680) 1 NC_002935.2 Similar to a family of proteins members of which are part of the antigen 85 complex responsible for the high affinity of mycobacteria for fibronectin. Similar to Corynebacterium ammoniagenes surface layer protein A SlpA SWALL:BAB62413 (EMBL:AB055224) (358 aa) fasta scores: E(): 2.6e-18, 31.23% id in 317 aa, and to Mycobacterium tuberculosis antigen 85-A precursor FbpA or Mpt44 or Rv3804c or MT3911 or MTV026.09c SWALL:A85A_MYCTU (SWALL:P17944) (338 aa) fasta scores: E(): 4.4e-18, 32.14% id in 280 aa, and to Corynebacterium glutamicum PS1 protein precursor Csp1 SWALL:CSP1_CORGL (SWALL:Q01377) (657 aa) fasta scores: E(): 5.2e-16, 30.02% id in 403 aa; major secreted protein 2446680 2649162 DIP2339 Corynebacterium diphtheriae NCTC 13129 major secreted protein NP_940640.1 2445460 R 257309 CDS NP_940641.1 38234874 2649163 2446717..2447712 1 NC_002935.2 Similar to members of a family of nucleoside hydrolases eg. Mycobacterium tuberculosis nucleoside hydrolase IunH or Rv3393 or MTV004.51 SWALL:O50418 (EMBL:AL009198) (308 aa) fasta scores: E(): 7.6e-27, 36.07% id in 316 aa, and to Crithidia fasciculata inosine-uridine preferring nucleoside hydrolase IunH SWALL:IUNH_CRIFA (SWALL:Q27546) (314 aa) fasta scores: E(): 2.7e-14, 28.07% id in 317 aa; nucleoside hydrolase 2447712 2649163 DIP2340 Corynebacterium diphtheriae NCTC 13129 nucleoside hydrolase NP_940641.1 2446717 D 257309 CDS NP_940642.1 38234875 2649164 2447808..2448566 1 NC_002935.2 Similar to Escherichia coli O157:H7 transporter ECS3800 SWALL:BAB37223 (EMBL:AP002563) (192 aa) fasta scores: E(): 6e-15, 30.16% id in 179 aa. Lies alongside a ABC transporter ATP-binding subunit; integral membrane transport protein 2448566 2649164 DIP2341 Corynebacterium diphtheriae NCTC 13129 integral membrane transport protein NP_940642.1 2447808 D 257309 CDS NP_940643.1 38234876 2649165 2448572..2449264 1 NC_002935.2 Similar to Streptomyces coelicolor integral membrane transport protein SCE87.11 SWALL:Q9RKC7 (EMBL:AL132674) (253 aa) fasta scores: E(): 0.082, 26.54% id in 226 aa; integral membrane transport protein 2449264 2649165 DIP2342 Corynebacterium diphtheriae NCTC 13129 integral membrane transport protein NP_940643.1 2448572 D 257309 CDS NP_940644.1 38234877 2649166 2449283..2450449 1 NC_002935.2 Similar to Streptomyces coelicolor ABC transporter ATP-binding subunit SCC53.15 SWALL:Q9KXJ6 (EMBL:AL357591) (563 aa) fasta scores: E(): 1.9e-05, 26.87% id in 439 aa, and to Methanobacterium thermoautotrophicum cobalt transport ATP-binding protein CbiO SWALL:Q50801 (EMBL:X94292) (277 aa) fasta scores: E(): 0.00012, 30.4% id in 171 aa; ABC transporter ATP-binding protein 2450449 2649166 DIP2343 Corynebacterium diphtheriae NCTC 13129 ABC transporter ATP-binding protein NP_940644.1 2449283 D 257309 CDS NP_940645.1 38234878 2649167 complement(2450460..2451242) 1 NC_002935.2 Weakly similar to many eg. Escherichia coli unknown protein from 2d-page YeaD or B1780 SWALL:UP08_ECOLI (SWALL:P39173) (294 aa) fasta scores: E(): 0.00013, 28.74% id in 247 aa; hypothetical protein 2451242 2649167 DIP2344 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940645.1 2450460 R 257309 CDS NP_940646.1 38234879 2649168 2451284..2451928 1 NC_002935.2 hypothetical protein 2451928 2649168 DIP2345 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940646.1 2451284 D 257309 CDS NP_940647.1 38234880 2649169 complement(2451936..2453429) 1 NC_002935.2 Similar to proteins from streptococci eg. Streptococcus pneumoniae hypothetical protein Sp0341 SWALL:AAK74515 (EMBL:AE007346) (494 aa) fasta scores: E(): 3.6e-101, 51.82% id in 492 aa, and to Streptococcus pyogenes hypothetical protein Spy1343 SWALL:Q99Z89 (EMBL:AE006572) (518 aa) fasta scores: E(): 8.2e-100, 50.9% id in 495 aa; hypothetical protein 2453429 2649169 DIP2346 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940647.1 2451936 R 257309 CDS NP_940648.1 38234881 2649170 complement(2453493..2453762) 1 NC_002935.2 Weakly similar to Rhizobium meliloti hypothetical protein Smc02732 r02394 or smc02732 TR:CAC46973 (EMBL:AL591790) (134 aa) fasta scores: E(): 1.4, 32.92% id in 82 aa; hypothetical protein 2453762 2649170 DIP2347 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940648.1 2453493 R 257309 CDS NP_940649.1 38234882 2649171 complement(2453759..2454376) 1 NC_002935.2 Weakly similar to Mycobacterium tuberculosis hypothetical 15.7 kDa protein Rv2011c precursor or MT2066 or MTCY39.06 SW:YK11_MYCTU (Q10846) (143 aa) fasta scores: E(): 5.2, 26.66% id in 135 aa; hypothetical protein 2454376 2649171 DIP2348 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940649.1 2453759 R 257309 CDS NP_940650.1 38234883 2649172 complement(2454544..2455788) 1 NC_002935.2 Similar to Treponema pallidum glutamate/aspartate transporter, tp0555 TR:O83566 (EMBL:AE001231) (396 aa) fasta scores: E(): 2.9e-33, 33.86% id in 375 aa; integral membrane transport protein 2455788 2649172 DIP2349 Corynebacterium diphtheriae NCTC 13129 integral membrane transport protein NP_940650.1 2454544 R 257309 CDS NP_940651.1 38234884 2649173 2455876..2456448 1 NC_002935.2 integral membrane protein 2456448 2649173 DIP2350 Corynebacterium diphtheriae NCTC 13129 integral membrane protein NP_940651.1 2455876 D 257309 CDS NP_940652.1 38234885 2649174 2456701..2458032 1 NC_002935.2 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 2458032 trpB1 2649174 trpB1 Corynebacterium diphtheriae NCTC 13129 tryptophan synthase subunit beta NP_940652.1 2456701 D 257309 CDS NP_940653.1 38234886 2649175 2458035..2459588 1 NC_002935.2 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 2459588 trpE 2649175 trpE Corynebacterium diphtheriae NCTC 13129 anthranilate synthase component I NP_940653.1 2458035 D 257309 CDS NP_940654.1 38234887 2649176 2459588..2460232 1 NC_002935.2 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 2460232 trpG 2649176 trpG Corynebacterium diphtheriae NCTC 13129 anthranilate synthase component II NP_940654.1 2459588 D 257309 CDS NP_940655.1 38234888 2649177 2460247..2461272 1 NC_002935.2 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 2461272 trpD 2649177 trpD Corynebacterium diphtheriae NCTC 13129 anthranilate phosphoribosyltransferase NP_940655.1 2460247 D 257309 CDS NP_940656.1 38234889 2649178 2461262..2462719 1 NC_002935.2 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 2462719 trpC1 2649178 trpC1 Corynebacterium diphtheriae NCTC 13129 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase NP_940656.1 2461262 D 257309 CDS NP_940657.1 38234890 2649179 2462780..2463157 1 NC_002935.2 Similar to Neisseria meningitidis membrane protein NMA0754 TR:Q9JVP6 (EMBL:AL162754) (119 aa) fasta scores: E(): 3.9e-14, 47.67% id in 86 aa, and to Escherichia coli, and hypothetical protein YanB or B0468 or Z0585 or ECS0521 SW:YBAN_ECOLI (P45808) (125 aa) fasta scores: E(): 1.2e-10, 37.83% id in 111 aa; hypothetical protein 2463157 2649179 DIP2356 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940657.1 2462780 D 257309 CDS NP_940658.1 38234891 2649180 2463154..2464014 1 NC_002935.2 Similar to Mycobacterium tuberculosis pantoate--beta-alanine ligase PanC or Rv3602c or MT3707 or MTCY07H7B.20 SW:PANC_MYCTU (O06280) (309 aa) fasta scores: E(): 1e-42, 47.65% id in 277 aa, and to Corynebacterium glutamicum pantoate--beta-alanine ligase PanC SW:PANC_CORGL (Q9X713) (279 aa) fasta scores: E(): 1.8e-32, 42.65% id in 279 aa; pantoate--beta-alanine ligase 2464014 panC 2649180 panC Corynebacterium diphtheriae NCTC 13129 pantoate--beta-alanine ligase NP_940658.1 2463154 D 257309 CDS NP_940659.1 38234892 2649181 complement(2464011..2464802) 1 NC_002935.2 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 2464802 panB 2649181 panB Corynebacterium diphtheriae NCTC 13129 3-methyl-2-oxobutanoate hydroxymethyltransferase NP_940659.1 2464011 R 257309 CDS NP_940660.1 38234893 2649182 2465139..2466365 1 NC_002935.2 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 2466365 trpB2 2649182 trpB2 Corynebacterium diphtheriae NCTC 13129 tryptophan synthase subunit beta NP_940660.1 2465139 D 257309 CDS NP_940661.1 38234894 2649183 2466370..2467206 1 NC_002935.2 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 2467206 trpA 2649183 trpA Corynebacterium diphtheriae NCTC 13129 tryptophan synthase subunit alpha NP_940661.1 2466370 D 257309 CDS NP_940662.1 38234895 2649184 2467213..2467623 1 NC_002935.2 Similar to Mycobacterium smegmatis Rieske iron-sulfur protein QcrA TR:Q9XBV4 (EMBL:AF155062) (138 aa) fasta scores: E(): 1.7e-11, 40.9% id in 132 aa, and to Streptomyces coelicolor iron-sulphur protein SCI51.03 TR:Q9S237 (EMBL:AL109848) (131 aa) fasta scores: E(): 3.8e-10, 35.15% id in 128 aa; iron-sulfur protein 2467623 2649184 DIP2362 Corynebacterium diphtheriae NCTC 13129 iron-sulfur protein NP_940662.1 2467213 D 257309 CDS NP_940663.1 38234896 2649185 2467644..2468612 1 NC_002935.2 Similar to Streptomyces coelicolor transmembrane protein SC4B5.06 TR:Q9ZBW2 (EMBL:AL034443) (345 aa) fasta scores: E(): 1.3e-52, 52.73% id in 311 aa; integral membrane protein 2468612 2649185 DIP2363 Corynebacterium diphtheriae NCTC 13129 integral membrane protein NP_940663.1 2467644 D 257309 CDS NP_940664.1 38234897 2649186 2468609..2468935 1 NC_002935.2 hypothetical protein 2468935 2649186 DIP2364 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940664.1 2468609 D 257309 CDS NP_940665.1 38234898 2649187 complement(2469062..2469427) 1 NC_002935.2 Similar to Bacillus subtilis branched-chain amino acid transport protein AzlD SW:AZLD_BACSU (O07923) (110 aa) fasta scores: E(): 8.2e-05, 36.27% id in 102 aa; integral membrane amino acid transport protein 2469427 2649187 DIP2365 Corynebacterium diphtheriae NCTC 13129 integral membrane amino acid transport protein NP_940665.1 2469062 R 257309 CDS NP_940666.1 38234899 2649188 complement(2469436..2470167) 1 NC_002935.2 Similar to Bacillus subtilis branched-chain amino acid transport protein AzlC SW:AZLC_BACSU (O07942) (254 aa) fasta scores: E(): 4.2e-14, 29.38% id in 211 aa; integral membrane amino acid transport protein 2470167 2649188 DIP2366 Corynebacterium diphtheriae NCTC 13129 integral membrane amino acid transport protein NP_940666.1 2469436 R 257309 CDS NP_940667.1 38234900 2649189 complement(2470168..2470764) 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 21.8 kDa protein Rv0038 or MT0043 or MTCY10h4.38 SW:Y038_MYCTU (P71608) (202 aa) fasta scores: E(): 4.4e-28, 43.64% id in 181 aa; hypothetical protein 2470764 2649189 DIP2367 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940667.1 2470168 R 257309 CDS NP_940668.1 38234901 2649190 complement(2470765..2472252) 1 NC_002935.2 Similar to a family of proteins from both prokaryotes and eukaryotes and including poly A polymerases and tRNA nucleotidyl transferases. Since prokaryotes don't generally have poly A tailed mRNAs the prokaryotic proteins are likely to be RNA nucleotidyl transferases. Similar to Mycobacterium tuberculosis PcnA or Rv3907c or MTCY15F10.04 TR:O05438 (EMBL:Z94121) (480 aa) fasta scores: E(): 3.5e-119, 64.61% id in 472 aa, and to Streptomyces coelicolor RNA nucleotidyltransferase SCH24.18 TR:Q9X8T2 (EMBL:AL049826) (483 aa) fasta scores: E(): 1.3e-103, 58.06% id in 465 aa. Similar to Escherichia coli tRNA nucleotidyltransferase Cca or B3056 SW:CCA_ECOLI (P06961) blast scores: E(): 2e-20, score: 250 30% id; tRNA nucleotidyltransferase 2472252 2649190 DIP2368 Corynebacterium diphtheriae NCTC 13129 tRNA nucleotidyltransferase NP_940668.1 2470765 R 257309 CDS NP_940669.1 38234902 2649191 2472392..2473264 1 NC_002935.2 Extensive (but not full length) similarity to Mycobacterium tuberculosis hypothetical 27.1 kDa protein Rv3908 or MTCY15f10.03C TR:O05437 (EMBL:Z94121) (248 aa) fasta scores: E(): 2.3e-25, 47.39% id in 211 aa. Has a hydrophilic N-terminal region.; hypothetical protein 2473264 2649191 DIP2369 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940669.1 2472392 D 257309 CDS NP_940670.1 38234903 2649192 2473261..2475975 1 NC_002935.2 Weak but full length similarity to Mycobacterium tuberculosis hypothetical 83.9 kDa protein Rv3909 or MTCY15F10.02c TR:O05436 (EMBL:Z94121) (802 aa) fasta scores: E(): 8.4e-10, 25.54% id in 916 aa; hypothetical protein 2475975 2649192 DIP2370 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940670.1 2473261 D 257309 CDS NP_940671.1 38234904 2649193 2476084..2479413 1 NC_002935.2 Similar to Mycobacterium tuberculosis hypothetical 123.6 kDa protein Rv3910 or MTCY15F10.01c or MTV028.01 TR:O05435 (EMBL:Z94121) (1184 aa) fasta scores: E(): 1.1e-83, 35.58% id in 1200 aa, and to Rhizobium tropici virulence factor MviN homolog SW:MVIN_RHITR (O05467) (533 aa) fasta scores: E(): 5.7e-15, 23.87% id in 553 aa; hypothetical protein 2479413 2649193 DIP2371 Corynebacterium diphtheriae NCTC 13129 hypothetical protein NP_940671.1 2476084 D 257309 CDS NP_940672.1 38234905 2649194 2479572..2480174 1 NC_002935.2 Similar to Pseudomonas fluorescens alternative sigma factor AlgU TR:AAK94006 (EMBL:AF399758) (193 aa) fasta scores: E(): 8.1e-12, 30.1% id in 186 aa, and to Pseudomonas aeruginosa RNA polymerase sigma-H factor AlgU or AlgT or PA0762 SW:RPSH_PSEAE (Q06198) (193 aa) fasta scores: E(): 1.8e-11, 29.03% id in 186 aa; RNA polymerase sigma factor 2480174 2649194 DIP2372 Corynebacterium diphtheriae NCTC 13129 RNA polymerase sigma factor NP_940672.1 2479572 D 257309 CDS NP_940673.1 38234906 2649195 2480310..2481254 1 NC_002935.2 Similar to Mycobacterium smegmatis thioredoxin reductase TrxB SW:TRXB_MYCSM (O30973) (311 aa) fasta scores: E(): 3.1e-72, 64.82% id in 307 aa; thioredoxin reductase 2481254 trxB 2649195 trxB Corynebacterium diphtheriae NCTC 13129 thioredoxin reductase NP_940673.1 2480310 D 257309 CDS NP_940674.1 38234907 2649196 2481269..2481592 1 NC_002935.2 Similar to Mycobacterium smegmatis thioredoxin TrxA SW:THIO_MYCSM (O30974) (112 aa) fasta scores: E(): 5.8e-18, 48.14% id in 108 aa; thioredoxin 2481592 trxA 2649196 trxA Corynebacterium diphtheriae NCTC 13129 thioredoxin NP_940674.1 2481269 D 257309 CDS NP_940675.1 38234908 2649197 2481613..2482821 1 NC_002935.2 Similar to Mycobacterium tuberculosis hydrolase CwlM or Rv3915 or MTV028.06 TR:O53593 (EMBL:AL021426) (406 aa) fasta scores: E(): 5.4e-78, 52.38% id in 399 aa, and to Bacillus subtilis N-acetylmuramoyl-L-alanine amidase CwlB precursor or LytC SW:CWLB_BACSU (Q02114) (496 aa) fasta scores: E(): 2.8e-07, 25.62% id in 199 aa; hydrolase 2482821 2649197 DIP2375 Corynebacterium diphtheriae NCTC 13129 hydrolase NP_940675.1 2481613 D 257309 CDS NP_940676.1 38234909 2649198 complement(2482889..2483992) 1 NC_002935.2 Similar to Mycobacterium tuberculosis probable chromosome partitioning protein ParB or Rv3917c or MT4036 or MTV028.08c SW:PARB_MYCTU (O53595) (344 aa) fasta scores: E(): 7.4e-47, 54.93% id in 375 aa, and to Streptomyces coelicolor chromosome partitioning protein ParB TR:Q9RFM2 (EMBL:AF187159) (368 aa) fasta scores: E(): 3.2e-43, 47.69% id in 369 aa; chromosome partitioning protein 2483992 parB 2649198 parB Corynebacterium diphtheriae NCTC 13129 chromosome partitioning protein NP_940676.1 2482889 R 257309 CDS NP_940677.1 38234910 2649199 complement(2483999..2485015) 1 NC_002935.2 Similar to Streptomyces coelicolor chromosome partitioning protein ParA TR:Q9RFM1 (EMBL:AF187159) (357 aa) fasta scores: E(): 2.5e-64, 63.6% id in 294 aa, and to Bacillus subtilis sporulation initiation inhibitor protein Soj SW:SOJ_BACSU (P37522) (253 aa) fasta scores: E(): 2.8e-45, 54.15% id in 253 aa; chromosome partitioning protein 2485015 parA 2649199 parA Corynebacterium diphtheriae NCTC 13129 chromosome partitioning protein NP_940677.1 2483999 R 257309 CDS NP_940678.1 38234911 2649200 complement(2485137..2485808) 1 NC_002935.2 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 2485808 gidB 2649200 gidB Corynebacterium diphtheriae NCTC 13129 16S rRNA methyltransferase GidB NP_940678.1 2485137 R 257309 CDS NP_940679.1 38234912 2649201 complement(2485931..2486884) 1 NC_002935.2 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 2486884 2649201 DIP2379 Corynebacterium diphtheriae NCTC 13129 inner membrane protein translocase component YidC NP_940679.1 2485931 R 257309 CDS NP_940680.1 38234913 2649203 complement(2487177..2487536) 1 NC_002935.2 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 2487536 rnpA 2649203 rnpA Corynebacterium diphtheriae NCTC 13129 ribonuclease P NP_940680.1 2487177 R 257309 CDS NP_940681.1 38234914 2649204 complement(2487568..2487711) 1 NC_002935.2 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 2487711 rpmH 2649204 rpmH Corynebacterium diphtheriae NCTC 13129 50S ribosomal protein L34 NP_940681.1 2487568 R 257309 CDS